GPCRdb

Ligand source activities (1 row/activity)

ChEMBL ID	Receptor	Species	Purchasable	p-value (-log)	Activity Type	Activity Relation	Activity Value	Unit	Assay Type	Assay Description	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles

CHEMBL408403	agtr1_human	Human	Yes	9.3	EC50	=	0.5	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay		None	None	None		None
CHEMBL408403	agtr1_human	Human	Yes	9.3	EC50	=	0.5	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay		None	None	None		None
CHEMBL3787243	agtr1_human	Human	No	9.0	EC50	=	1.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1216	35	15	14	-0.7	CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787375	agtr1_human	Human	No	9.0	EC50	=	1.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1216	35	15	14	-0.7	CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787700	agtr1_human	Human	No	9.0	EC50	=	1.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1216	35	15	14	-0.7	CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787243	agtr1_human	Human	No	9.0	EC50	=	1.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1216	35	15	14	-0.7	CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787375	agtr1_human	Human	No	9.0	EC50	=	1.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1216	35	15	14	-0.7	CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787700	agtr1_human	Human	No	9.0	EC50	=	1.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1216	35	15	14	-0.7	CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL408403	agtra_rat	Rat	Yes	8.9	EC50	=	1.3	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		None
CHEMBL3786145	agtr1_human	Human	No	8.9	EC50	=	1.4	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1160	33	15	14	-1.2	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787767	agtr1_human	Human	No	8.9	EC50	=	1.4	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1160	33	15	14	-1.2	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3786145	agtr1_human	Human	No	8.9	EC50	=	1.4	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1160	33	15	14	-1.2	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787767	agtr1_human	Human	No	8.9	EC50	=	1.4	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1160	33	15	14	-1.2	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL4483576	agtr1_human	Human	No	8.0	EC50	=	10	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	945	26	13	13	-2.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4514079	agtra_rat	Rat	No	8.0	EC50	=	10	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	944	26	13	12	-1.8	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4518318	agtr1_human	Human	No	7.0	EC50	=	100	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	926	25	12	12	-2.0	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4535678	agtr1_human	Human	No	7.0	EC50	=	100	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	942	26	14	13	-2.2	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4572408	agtra_rat	Rat	No	7.0	EC50	=	100	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	2296	33	30	27	-2.1	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4577692	agtra_rat	Rat	No	7.0	EC50	=	100	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1081	26	13	12	-0.4	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4532075	agtr1_human	Human	No	6.0	EC50	=	1000	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	966	26	12	12	-1.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4592000	agtr1_human	Human	No	6.0	EC50	=	1000	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	898	26	11	12	-1.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4556070	agtr1_human	Human	No	5.0	EC50	=	10000	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	980	26	12	12	-0.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4524570	agtra_rat	Rat	No	5.0	EC50	=	10000	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	959	27	13	12	-1.6	CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4556070	agtra_rat	Rat	No	5.0	EC50	=	10000	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	980	26	12	12	-0.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL938	agtr1_human	Human	Yes	8.0	EC50	=	11	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL4438122	agtra_rat	Rat	No	8.0	EC50	=	11	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		None
CHEMBL4559239	agtr1_human	Human	No	7.0	EC50	=	110	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	790	23	12	11	-4.6	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C
CHEMBL4529051	agtra_rat	Rat	No	7.0	EC50	=	110	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	853	24	12	11	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O
CHEMBL4518530	agtr1_human	Human	No	7.9	EC50	=	12	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	954	28	13	12	-1.1	CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL4518530	agtra_rat	Rat	No	7.9	EC50	=	12	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	954	28	13	12	-1.1	CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL4515768	agtra_rat	Rat	No	6.9	EC50	=	120	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	953	27	13	12	-1.9	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4517561	agtra_rat	Rat	No	6.9	EC50	=	120	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	904	27	12	11	-1.2	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O
CHEMBL4482867	agtr1_human	Human	No	5.9	EC50	=	1200	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	14	13	-2.3	CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4561769	agtr1_human	Human	No	5.9	EC50	=	1200	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	945	26	13	12	-1.8	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4572408	agtr1_human	Human	No	5.9	EC50	=	1200	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	2296	33	30	27	-2.1	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL27511	agtr1_bovin	Bovine	No	5.9	EC50	=	1250	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	486	5	2	7	5.0	Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1
CHEMBL281887	agtr1_bovin	Bovine	No	5.9	EC50	=	1250	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	461	5	2	6	4.6	O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2
CHEMBL4514079	agtr1_human	Human	No	7.9	EC50	=	13	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	944	26	13	12	-1.8	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4518318	agtra_rat	Rat	No	7.9	EC50	=	13	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	926	25	12	12	-2.0	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4533618	agtra_rat	Rat	No	7.9	EC50	=	13	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	959	26	13	12	-1.3	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4549405	agtra_rat	Rat	No	7.9	EC50	=	13	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	959	26	13	12	-1.7	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4522246	agtra_rat	Rat	No	6.9	EC50	=	130	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4524300	agtr1_human	Human	No	5.9	EC50	=	1300	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	975	27	14	13	-1.9	CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL2028943	agtra_rat	Rat	No	7.9	EC50	=	14	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL2370909	agtra_rat	Rat	No	6.9	EC50	=	140	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4522038	agtr1_human	Human	No	5.9	EC50	=	1400	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	904	24	13	12	-1.5	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
CHEMBL4574199	agtr1_human	Human	No	5.9	EC50	=	1400	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	14	13	-2.1	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4516768	agtra_rat	Rat	No	5.9	EC50	=	1400	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	947	25	14	13	-2.5	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL2392353	agtra_rat	Rat	Yes	7.8	EC50	=	15	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL4297447	agtra_rat	Rat	Yes	7.8	EC50	=	16	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL4591857	agtra_rat	Rat	No	7.8	EC50	=	16	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	927	26	13	13	-2.9	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL2028943	agtr1_human	Human	No	6.8	EC50	=	160	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4518420	agtr1_human	Human	No	6.8	EC50	=	160	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	928	26	12	11	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4573250	agtr1_human	Human	No	6.8	EC50	=	160	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	925	26	13	12	-2.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O
CHEMBL4557984	agtra_rat	Rat	No	6.8	EC50	=	160	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	13	12	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4588454	agtra_rat	Rat	Yes	6.8	EC50	=	160	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	955	27	14	13	-2.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL4527484	agtr1_human	Human	No	5.8	EC50	=	1600	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	887	24	12	11	-1.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4544308	agtr1_human	Human	No	5.8	EC50	=	1600	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	791	23	12	11	-4.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL4570840	agtr1_human	Human	No	5.8	EC50	=	1600	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	811	22	12	11	-3.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4571382	agtr1_human	Human	No	5.8	EC50	=	1600	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	966	29	12	12	-1.1	C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1
CHEMBL4576650	agtr1_human	Human	No	5.8	EC50	=	1600	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1177	26	13	12	-0.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4576650	agtra_rat	Rat	No	4.8	EC50	=	16000	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	1177	26	13	12	-0.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4542269	agtr1_human	Human	No	7.8	EC50	=	17	nM	Bind	Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay	877	29	13	12	-2.3	CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4297447	agtr1_human	Human	Yes	7.8	EC50	=	17	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL4577691	agtra_rat	Rat	No	7.8	EC50	=	17	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	840	23	12	11	-1.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C
CHEMBL4551317	agtr1_human	Human	No	5.8	EC50	=	1700	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	2269	27	21	24	3.8	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL25226	agtr1_bovin	Bovine	No	5.8	EC50	=	1700	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	471	5	2	6	5.3	O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL4564950	agtra_rat	Rat	No	7.8	EC50	=	18	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	975	26	14	13	-2.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4573250	agtra_rat	Rat	No	6.8	EC50	=	180	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	925	26	13	12	-2.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O
CHEMBL4579604	agtra_rat	Rat	No	6.8	EC50	=	180	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	14	13	-2.1	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4554466	agtr1_human	Human	No	5.8	EC50	=	1800	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	910	26	12	11	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL24842	agtr1_bovin	Bovine	No	5.8	EC50	=	1800	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	491	7	2	5	6.2	CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1
CHEMBL4567667	agtra_rat	Rat	No	7.7	EC50	=	19	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1052	28	14	13	-0.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C
CHEMBL4515768	agtr1_human	Human	No	6.7	EC50	=	190	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	953	27	13	12	-1.9	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4544308	agtra_rat	Rat	No	5.7	EC50	=	1900	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	791	23	12	11	-4.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL4551317	agtra_rat	Rat	No	5.7	EC50	=	1900	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	2269	27	21	24	3.8	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4572408	agtra_rat	Rat	No	5.7	EC50	=	1900	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	2296	33	30	27	-2.1	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL3786986	agtr1_human	Human	No	8.7	EC50	=	2.0	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1220	37	15	16	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787768	agtr1_human	Human	No	8.7	EC50	=	2.0	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1220	37	15	16	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3786986	agtr1_human	Human	No	8.7	EC50	=	2.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1220	37	15	16	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787768	agtr1_human	Human	No	8.7	EC50	=	2.1	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1220	37	15	16	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787379	agtr1_human	Human	No	8.6	EC50	=	2.3	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1276	39	15	16	-1.4	CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787701	agtr1_human	Human	No	8.6	EC50	=	2.3	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1276	39	15	16	-1.4	CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787379	agtr1_human	Human	No	8.6	EC50	=	2.4	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1276	39	15	16	-1.4	CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787701	agtr1_human	Human	No	8.6	EC50	=	2.4	nM	Funct	Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay	1276	39	15	16	-1.4	CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL408403	agtr1_human	Human	Yes	8.6	EC50	=	2.6	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		None
CHEMBL4518530	agtr1_human	Human	No	8.6	EC50	=	2.7	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	954	28	13	12	-1.1	CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL4567667	agtr1_human	Human	No	7.7	EC50	=	20	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1052	28	14	13	-0.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C
CHEMBL4588454	agtra_rat	Rat	Yes	7.7	EC50	=	20	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	955	27	14	13	-2.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL4542709	agtr1_human	Human	No	6.7	EC50	=	200	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	911	26	13	12	-2.2	CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4554466	agtra_rat	Rat	No	6.7	EC50	=	200	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	910	26	12	11	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4545399	agtra_rat	Rat	No	6.7	EC50	=	200	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	27	12	12	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4555119	agtra_rat	Rat	No	6.7	EC50	=	200	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	911	25	13	12	-2.9	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C
CHEMBL4590381	agtr1_human	Human	No	5.7	EC50	=	2000	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	945	26	13	12	-2.0	CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL2392353	agtr1_human	Human	Yes	7.7	EC50	=	21	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL4555119	agtr1_human	Human	No	6.7	EC50	=	210	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	911	25	13	12	-2.9	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C
CHEMBL4544228	agtr1_human	Human	No	5.7	EC50	=	2100	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL4482867	agtra_rat	Rat	No	5.7	EC50	=	2100	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	14	13	-2.3	CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4546162	agtra_rat	Rat	No	5.7	EC50	=	2100	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4588946	agtr1_human	Human	Yes	6.7	EC50	=	220	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	742	22	12	10	-2.4	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL4573250	agtra_rat	Rat	No	6.7	EC50	=	220	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	925	26	13	12	-2.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O
CHEMBL28162	agtr1_bovin	Bovine	No	5.7	EC50	=	2200	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	501	6	2	7	5.3	COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1
CHEMBL4516066	agtra_rat	Rat	No	6.6	EC50	=	230	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1017	28	14	13	-1.6	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4562270	agtra_rat	Rat	No	7.6	EC50	=	24	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	940	26	12	12	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4551317	agtra_rat	Rat	No	6.6	EC50	=	240	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	2269	27	21	24	3.8	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4533618	agtr1_human	Human	No	7.6	EC50	=	25	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	959	26	13	12	-1.3	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4591448	agtr1_human	Human	No	7.6	EC50	=	25	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4564617	agtra_rat	Rat	No	7.6	EC50	=	25	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	970	27	13	14	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4516066	agtr1_human	Human	No	6.6	EC50	=	250	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	1017	28	14	13	-1.6	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4577692	agtr1_human	Human	No	6.6	EC50	=	250	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1081	26	13	12	-0.4	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4547423	agtra_rat	Rat	No	6.6	EC50	=	250	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	949	26	14	13	-3.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4559421	agtra_rat	Rat	No	5.6	EC50	=	2500	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	1015	28	13	16	-2.1	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4561366	agtra_rat	Rat	No	5.6	EC50	=	2500	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	756	9	7	8	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4533618	agtra_rat	Rat	No	4.6	EC50	=	25000	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	959	26	13	12	-1.3	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4583284	agtra_rat	Rat	No	4.6	EC50	=	25000	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	954	26	13	12	-1.3	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4560224	agtra_rat	Rat	No	7.6	EC50	=	26	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	897	26	15	12	-3.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4544228	agtra_rat	Rat	No	6.6	EC50	=	260	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		None
CHEMBL4516768	agtra_rat	Rat	No	6.6	EC50	=	260	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	947	25	14	13	-2.5	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4547423	agtra_rat	Rat	No	7.6	EC50	=	27	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	949	26	14	13	-3.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4560224	agtra_rat	Rat	No	7.6	EC50	=	27	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	897	26	15	12	-3.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4547423	agtr1_human	Human	No	6.6	EC50	=	270	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	949	26	14	13	-3.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4567103	agtra_rat	Rat	No	6.6	EC50	=	270	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	917	28	13	12	-1.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4590589	agtra_rat	Rat	No	6.6	EC50	=	270	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	877	24	13	12	-3.1	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4554466	agtra_rat	Rat	No	5.6	EC50	=	2700	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	910	26	12	11	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL274447	agtr1_bovin	Bovine	Yes	5.6	EC50	=	2700	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	398	8	2	4	4.8	CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL4590381	agtra_rat	Rat	No	5.6	EC50	=	2800	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	945	26	13	12	-2.0	CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL77838	agtr1_human	Human	Yes	8.5	EC50	=	3.4	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O
CHEMBL77838	agtra_rat	Rat	Yes	8.5	EC50	=	3.5	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O
CHEMBL4543860	agtr1_human	Human	No	8.4	EC50	=	3.6	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	947	25	14	13	-2.5	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4560224	agtr1_human	Human	No	7.5	EC50	=	30	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	897	26	15	12	-3.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4522038	agtra_rat	Rat	No	6.5	EC50	=	300	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	904	24	13	12	-1.5	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
CHEMBL4564950	agtr1_human	Human	No	7.5	EC50	=	31	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	975	26	14	13	-2.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4536886	agtra_rat	Rat	No	7.5	EC50	=	31	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	926	25	13	12	-1.9	CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C
CHEMBL4593310	agtra_rat	Rat	No	7.5	EC50	=	31	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	869	25	13	12	-3.2	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4591857	agtr1_human	Human	No	7.5	EC50	=	32	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	927	26	13	13	-2.9	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL2028943	agtra_rat	Rat	No	7.5	EC50	=	32	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4591448	agtra_rat	Rat	No	7.5	EC50	=	32	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4522246	agtr1_human	Human	No	6.5	EC50	=	320	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4549405	agtr1_human	Human	No	7.5	EC50	=	33	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	959	26	13	12	-1.7	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4516768	agtr1_human	Human	No	6.5	EC50	=	330	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	947	25	14	13	-2.5	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4529051	agtr1_human	Human	No	6.5	EC50	=	330	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	853	24	12	11	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O
CHEMBL4543860	agtra_rat	Rat	No	6.5	EC50	=	330	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	947	25	14	13	-2.5	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4579604	agtr1_human	Human	No	6.5	EC50	=	340	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	14	13	-2.1	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4555119	agtra_rat	Rat	No	7.5	EC50	=	35	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	911	25	13	12	-2.9	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C
CHEMBL191	agtr1_bovin	Bovine	Yes	6.5	EC50	=	350	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	422	8	2	6	4.3	CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl
CHEMBL4581718	agtra_rat	Rat	No	6.4	EC50	=	360	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	917	28	12	11	-1.4	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O
CHEMBL4574655	agtra_rat	Rat	No	5.4	EC50	=	3600	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	941	27	14	13	-3.1	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4518318	agtra_rat	Rat	No	7.4	EC50	=	37	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	926	25	12	12	-2.0	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4577270	agtra_rat	Rat	No	7.4	EC50	=	38	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	903	24	13	12	-2.1	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4515848	agtr1_human	Human	No	7.4	EC50	=	39	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4438122	agtra_rat	Rat	No	7.4	EC50	=	39	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL4515768	agtr1_human	Human	No	6.4	EC50	=	390	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	953	27	13	12	-1.9	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4524300	agtra_rat	Rat	No	5.4	EC50	=	3900	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	975	27	14	13	-1.9	CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL312754	agtra_rat	Rat	Yes	8.3	EC50	=	4.8	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4536886	agtr1_human	Human	No	7.4	EC50	=	40	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	926	25	13	12	-1.9	CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C
CHEMBL4535997	agtra_rat	Rat	No	7.4	EC50	=	40	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	943	26	14	14	-3.2	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4557984	agtr1_human	Human	No	6.4	EC50	=	400	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	13	12	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4583284	agtra_rat	Rat	No	6.4	EC50	=	400	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	954	26	13	12	-1.3	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4559421	agtra_rat	Rat	No	5.4	EC50	=	4000	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1015	28	13	16	-2.1	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4517561	agtra_rat	Rat	No	7.4	EC50	=	41	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	904	27	12	11	-1.2	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O
CHEMBL4577691	agtr1_human	Human	No	7.4	EC50	=	42	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	840	23	12	11	-1.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C
CHEMBL4588946	agtra_rat	Rat	Yes	7.4	EC50	=	42	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	742	22	12	10	-2.4	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL4570840	agtra_rat	Rat	No	6.4	EC50	=	420	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	811	22	12	11	-3.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4562270	agtra_rat	Rat	No	7.4	EC50	=	43	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	12	12	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4543860	agtr1_human	Human	No	6.4	EC50	=	430	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	947	25	14	13	-2.5	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4564094	agtra_rat	Rat	No	4.4	EC50	=	43000	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	782	21	11	10	-1.4	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4438122	agtr1_human	Human	No	7.4	EC50	=	44	nM	Bind	Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay		None	None	None		None
CHEMBL4438122	agtr1_human	Human	No	7.4	EC50	=	44	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL4522038	agtra_rat	Rat	No	6.4	EC50	=	440	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	904	24	13	12	-1.5	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
CHEMBL4517561	agtr1_human	Human	No	6.4	EC50	=	450	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	904	27	12	11	-1.2	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O
CHEMBL4543860	agtra_rat	Rat	No	6.4	EC50	=	450	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	947	25	14	13	-2.5	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4581718	agtr1_human	Human	No	5.4	EC50	=	4500	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	917	28	12	11	-1.4	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O
CHEMBL4564094	agtr1_human	Human	No	5.3	EC50	=	4600	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	782	21	11	10	-1.4	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4545153	agtr1_human	Human	No	6.3	EC50	=	480	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	969	28	16	13	-3.7	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4546162	agtr1_human	Human	No	5.3	EC50	=	4800	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4483576	agtra_rat	Rat	No	8.3	EC50	=	5	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	945	26	13	13	-2.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4535997	agtr1_human	Human	No	7.3	EC50	=	50	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	943	26	14	14	-3.2	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4542709	agtra_rat	Rat	No	7.3	EC50	=	50	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	911	26	13	12	-2.2	CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4532075	agtra_rat	Rat	No	6.3	EC50	=	500	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	966	26	12	12	-1.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4576650	agtra_rat	Rat	No	6.3	EC50	=	500	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1177	26	13	12	-0.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL282566	agtr1_bovin	Bovine	No	6.3	EC50	=	500	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	515	7	2	7	5.7	CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1
CHEMBL4559421	agtr1_human	Human	No	5.3	EC50	=	5000	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1015	28	13	16	-2.1	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL3355127	agtr1_human	Human	No	5.3	EC50	=	5100	nM	Bind	Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)	422	2	1	5	3.6	C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12
CHEMBL4551431	agtr1_human	Human	No	6.3	EC50	=	530	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	931	25	13	12	-2.2	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4551431	agtra_rat	Rat	No	6.3	EC50	=	530	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	931	25	13	12	-2.2	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4588454	agtr1_human	Human	Yes	6.3	EC50	=	550	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	955	27	14	13	-2.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL3355137	agtr1_human	Human	No	5.3	EC50	=	5500	nM	Bind	Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)	436	2	1	5	3.9	Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1
CHEMBL1460676	agtr1_human	Human	Yes	4.2	EC50	=	57800	nM	Funct	PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]	548	8	0	6	5.0	Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1
CHEMBL1621632	agtr1_human	Human	Yes	4.2	EC50	=	57800	nM	Funct	PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]	548	8	0	6	5.0	Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1
CHEMBL4559239	agtra_rat	Rat	No	7.2	EC50	=	59	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	790	23	12	11	-4.6	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C
CHEMBL4545399	agtr1_human	Human	No	6.2	EC50	=	590	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	27	12	12	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL938	agtra_rat	Rat	Yes	8.2	EC50	=	6	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL77838	agtra_rat	Rat	Yes	8.2	EC50	=	6.1	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O
CHEMBL312754	agtra_rat	Rat	Yes	8.2	EC50	=	6.6	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4588946	agtra_rat	Rat	Yes	8.2	EC50	=	6.8	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	742	22	12	10	-2.4	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL408403	agtra_rat	Rat	Yes	8.2	EC50	=	6.8	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL282082	agtr1_bovin	Bovine	No	6.2	EC50	=	600	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	517	6	2	7	6.0	CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1
CHEMBL26875	agtr1_bovin	Bovine	No	5.2	EC50	=	6000	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	477	5	2	7	5.3	O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL4564617	agtr1_human	Human	No	7.2	EC50	=	63	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	970	27	13	14	-2.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4515848	agtra_rat	Rat	No	7.2	EC50	=	63	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4535678	agtra_rat	Rat	No	7.2	EC50	=	63	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	942	26	14	13	-2.2	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4545153	agtra_rat	Rat	No	7.2	EC50	=	63	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	969	28	16	13	-3.7	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4583284	agtr1_human	Human	No	6.2	EC50	=	630	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	954	26	13	12	-1.3	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4590589	agtr1_human	Human	No	6.2	EC50	=	630	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	877	24	13	12	-3.1	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4571382	agtra_rat	Rat	No	6.2	EC50	=	630	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	966	29	12	12	-1.1	C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1
CHEMBL4592000	agtra_rat	Rat	No	6.2	EC50	=	630	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	898	26	11	12	-1.0	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4567667	agtra_rat	Rat	No	7.2	EC50	=	64	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	1052	28	14	13	-0.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C
CHEMBL4544308	agtr1_human	Human	No	7.2	EC50	=	65	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	791	23	12	11	-4.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL4588454	agtr1_human	Human	Yes	6.2	EC50	=	660	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	955	27	14	13	-2.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL4527484	agtra_rat	Rat	No	6.2	EC50	=	660	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	887	24	12	11	-1.8	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4524570	agtr1_human	Human	No	5.2	EC50	=	6700	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	959	27	13	12	-1.6	CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4561366	agtr1_human	Human	No	6.2	EC50	=	680	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	756	9	7	8	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4567103	agtr1_human	Human	No	6.2	EC50	=	680	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	917	28	13	12	-1.7	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL2392353	agtra_rat	Rat	Yes	8.1	EC50	=	7.3	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		None
CHEMBL4545153	agtra_rat	Rat	No	8.1	EC50	=	7.4	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	969	28	16	13	-3.7	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL938	agtra_rat	Rat	Yes	8.1	EC50	=	7.5	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL4544902	agtr1_human	Human	No	8.1	EC50	=	7.9	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	13	13	-2.3	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4544902	agtra_rat	Rat	No	8.1	EC50	=	7.9	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	13	13	-2.3	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL1704271	agtr1_human	Human	Yes	5.1	EC50	=	7440	nM	Funct	PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]	436	4	0	5	5.8	CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O
CHEMBL4577270	agtr1_human	Human	No	7.1	EC50	=	75	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	903	24	13	12	-2.1	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4516066	agtra_rat	Rat	No	7.1	EC50	=	77	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	1017	28	14	13	-1.6	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4562270	agtr1_human	Human	No	7.1	EC50	=	79	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	940	26	12	12	-1.6	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4515768	agtra_rat	Rat	No	7.1	EC50	=	79	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	953	27	13	12	-1.9	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4518420	agtra_rat	Rat	No	7.1	EC50	=	79	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	928	26	12	11	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL2028943	agtr1_human	Human	No	8.1	EC50	=	8	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4515848	agtra_rat	Rat	No	8.1	EC50	=	8.2	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	940	26	13	12	-1.5	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4546799	agtra_rat	Rat	No	8.1	EC50	=	8.2	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	927	26	13	13	-2.9	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4516066	agtr1_human	Human	No	6.1	EC50	=	820	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	1017	28	14	13	-1.6	CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4574199	agtra_rat	Rat	No	6.1	EC50	=	820	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	961	26	14	13	-2.1	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4561769	agtra_rat	Rat	No	6.1	EC50	=	870	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	945	26	13	12	-1.8	CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL2370909	agtr1_human	Human	No	6.1	EC50	=	880	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4546799	agtr1_human	Human	No	8.0	EC50	=	9.2	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	927	26	13	13	-2.9	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL312754	agtr1_human	Human	Yes	8.0	EC50	=	9.2	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4518530	agtra_rat	Rat	No	8.0	EC50	=	9.3	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	954	28	13	12	-1.1	CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL408403	agtr1_human	Human	Yes	8.0	EC50	=	9.7	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL284877	agtr1_bovin	Bovine	No	7.1	EC50	=	90	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	505	6	2	7	5.9	CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1
CHEMBL4544228	agtra_rat	Rat	No	6.0	EC50	=	910	nM	Bind	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay		None	None	None		None
CHEMBL2370909	agtra_rat	Rat	No	7.0	EC50	=	92	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4559239	agtr1_human	Human	No	6.0	EC50	=	920	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	790	23	12	11	-4.6	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C
CHEMBL4561366	agtra_rat	Rat	No	6.0	EC50	=	920	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	756	9	7	8	1.3	CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4593310	agtr1_human	Human	No	7.0	EC50	=	95	nM	Bind	Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay	869	25	13	12	-3.2	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL28160	agtr1_bovin	Bovine	No	5.0	EC50	=	9500	nM	Bind	Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex	477	6	2	5	5.8	COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1
CHEMBL4588946	agtr1_human	Human	Yes	7.0	EC50	=	96	nM	Funct	Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	742	22	12	10	-2.4	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL4544308	agtra_rat	Rat	No	7.0	EC50	=	96	nM	Funct	Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay	791	23	12	11	-4.0	CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL138690	agtr1_rabit	Rabbit	No	10.4	IC50	=	0.0	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	729	12	2	9	7.1	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL138690	agtr1_rabit	Rabbit	No	10.4	IC50	=	0.0	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	729	12	2	9	7.1	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL346728	agtr1_human	Human	No	10.3	IC50	=	0.1	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	614	9	1	6	7.0	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1
CHEMBL265797	agtr1_rabit	Rabbit	No	10.3	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	691	11	2	8	6.5	CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL265797	agtr1_rabit	Rabbit	No	10.3	IC50	=	0.1	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	691	11	2	8	6.5	CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL265797	agtr1_rabit	Rabbit	No	10.3	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	691	11	2	8	6.5	CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL48242	agtr1_rabit	Rabbit	Yes	10.3	IC50	=	0.1	nM	Funct	Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response	452	8	2	6	5.0	CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL341828	agtr1_rabit	Rabbit	No	10.1	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	695	13	2	9	7.1	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1
CHEMBL339672	agtr1_rabit	Rabbit	No	10.1	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	723	12	2	8	7.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL339672	agtr1_rabit	Rabbit	No	10.1	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	723	12	2	8	7.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL341828	agtr1_rabit	Rabbit	No	10.1	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	695	13	2	9	7.1	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1
CHEMBL339672	agtr1_rabit	Rabbit	No	10.1	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	723	12	2	8	7.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL343309	agtr1_rabit	Rabbit	No	10.1	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	717	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL343309	agtr1_rabit	Rabbit	No	10.1	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	717	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL339722	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL24322	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA	550	9	2	7	5.5	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL305017	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	782	17	1	9	8.2	CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL305238	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	706	16	2	9	6.9	CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL307318	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	706	17	2	9	7.0	CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1
CHEMBL69721	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	693	17	1	9	7.3	CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70161	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	705	17	1	9	7.5	CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70370	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	707	18	1	9	7.5	CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70789	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	679	15	1	9	7.1	CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70843	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	746	16	1	10	6.6	CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70935	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	677	15	1	9	6.8	CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL24322	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane	550	9	2	7	5.5	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2435828	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis	531	10	2	4	7.3	CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL24322	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta	550	9	2	7	5.5	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL304947	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	657	15	2	7	7.7	CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C
CHEMBL68638	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	544	9	1	6	6.1	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1
CHEMBL339722	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL24322	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta	550	9	2	7	5.5	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL24322	agtr1_human	Human	No	10.0	IC50	=	0.1	nM	Bind	Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1	550	9	2	7	5.5	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL316300	agtr1_rabit	Rabbit	Yes	10.0	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	668	10	1	7	6.9	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL341934	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	719	13	2	8	7.3	CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL343142	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	733	13	2	8	7.5	CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL316300	agtr1_rabit	Rabbit	Yes	10.0	IC50	=	0.1	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	668	10	1	7	6.9	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL306407	agtr1_rabit	Rabbit	Yes	10.0	IC50	=	0.1	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	633	15	2	8	7.1	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1
CHEMBL316300	agtr1_rabit	Rabbit	Yes	10.0	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	668	10	1	7	6.9	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL316300	agtr1_rabit	Rabbit	Yes	10.0	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	668	10	1	7	6.9	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL341934	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	719	13	2	8	7.3	CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL343142	agtr1_rabit	Rabbit	No	10.0	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	733	13	2	8	7.5	CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL140708	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	767	13	2	8	7.7	CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL124771	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	729	11	2	9	6.6	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL68618	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	643	15	2	7	7.4	CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1
CHEMBL124771	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	729	11	2	9	6.6	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL140708	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	767	13	2	8	7.7	CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL353037	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	633	12	3	8	5.8	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL124771	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	729	11	2	9	6.6	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL332576	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	691	12	2	9	6.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F
CHEMBL339256	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	757	12	2	8	7.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL339605	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	685	11	2	9	6.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL332576	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	691	12	2	9	6.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F
CHEMBL339256	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	757	12	2	8	7.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL339605	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	685	11	2	9	6.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL330533	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	652	10	1	7	6.4	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1
CHEMBL306362	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	691	13	2	8	6.7	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F
CHEMBL139452	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	734	13	3	8	7.0	CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338101	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	733	14	2	8	7.0	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL332909	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	723	12	2	8	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL338101	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	733	14	2	8	7.0	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL435811	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL332909	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	723	12	2	8	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL338101	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	733	14	2	8	7.0	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL435811	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL435811	agtr1_human	Human	No	9.9	IC50	=	0.1	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL139452	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	734	13	3	8	7.0	CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338101	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	733	14	2	8	7.0	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL332909	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	723	12	2	8	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL338101	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	733	14	2	8	7.0	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL435811	agtr1_rabit	Rabbit	No	9.9	IC50	=	0.1	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL329679	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	686	10	1	7	7.0	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL94905	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	640	10	1	7	6.5	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1
CHEMBL352771	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	651	11	3	7	6.1	CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL353800	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	647	13	3	8	6.2	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL136465	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	733	11	2	8	7.5	CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL96075	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	733	14	2	8	7.6	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL338027	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	729	11	2	9	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339004	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	751	14	2	8	7.2	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL96075	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	733	14	2	8	7.6	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL338027	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	729	11	2	9	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339004	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	751	14	2	8	7.2	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL316706	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	636	11	1	8	5.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1
CHEMBL136465	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	733	11	2	8	7.5	CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL96075	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	733	14	2	8	7.6	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL317343	agtrb_rat	Rat	No	9.8	IC50	=	0.2	nM	Bind	Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50	492	10	2	5	6.1	CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl
CHEMBL338027	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	729	11	2	9	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339004	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	751	14	2	8	7.2	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL93907	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	705	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340632	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	713	13	2	9	6.6	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL93907	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	705	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL72838	agtr1_human	Human	No	9.8	IC50	=	0.2	nM	Bind	Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1	425	4	2	8	3.0	Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1
CHEMBL93907	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	705	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340632	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	713	13	2	9	6.6	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL93907	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	705	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL97075	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	706	10	1	8	7.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1
CHEMBL98068	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	748	12	1	9	8.0	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC
CHEMBL93907	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	705	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL354779	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	661	14	3	8	6.6	CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL93907	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	705	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340632	agtr1_rabit	Rabbit	No	9.8	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	713	13	2	9	6.6	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL337118	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	719	12	2	8	7.1	CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL329616	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	546	9	2	6	6.7	CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL337118	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	719	12	2	8	7.1	CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL169221	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	619	12	3	8	5.4	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
CHEMBL169568	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	633	13	3	8	5.8	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1
CHEMBL125008	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	777	11	2	9	7.5	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL2236976	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	771	13	2	8	8.0	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL125008	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	777	11	2	9	7.5	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL331450	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	723	12	2	8	6.1	CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1
CHEMBL1184032	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	692	10	1	8	7.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL329290	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	692	10	1	8	7.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL311160	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	687	10	3	7	6.2	CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
CHEMBL415073	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	679	13	2	8	6.7	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
CHEMBL352503	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	632	14	2	8	6.4	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1
CHEMBL125008	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	777	11	2	9	7.5	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL2236976	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	771	13	2	8	8.0	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL122917	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	717	12	2	8	6.8	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F
CHEMBL331507	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	735	12	2	10	6.0	CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL293511	agtr1_human	Human	Yes	9.7	IC50	=	0.2	nM	Funct	Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor	524	7	1	6	5.4	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL288246	agtr1_rabit	Rabbit	Yes	9.7	IC50	=	0.2	nM	Funct	Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta	510	9	1	8	3.5	CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
CHEMBL302964	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	707	18	1	9	7.7	CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL303427	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	792	19	1	10	8.6	CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL308323	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	741	17	1	10	6.7	CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL311253	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	732	15	1	10	6.2	CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL311625	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	725	17	1	9	7.1	CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL430792	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	720	17	2	9	7.3	CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70868	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	790	21	1	9	8.5	CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL71172	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	739	16	1	9	8.1	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
CHEMBL71639	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	709	17	1	9	8.1	CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL73283	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	773	16	1	9	8.2	CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL293511	agtr1_rabit	Rabbit	Yes	9.7	IC50	=	0.2	nM	Bind	Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings	524	7	1	6	5.4	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL105199	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1	534	9	1	7	5.8	CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1
CHEMBL293511	agtr1_rabit	Rabbit	Yes	9.7	IC50	=	0.2	nM	Bind	Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1	524	7	1	6	5.4	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL318605	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1	520	9	1	7	5.5	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1
CHEMBL433646	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	492	10	2	6	5.4	CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL293511	agtr1_rabit	Rabbit	Yes	9.7	IC50	=	0.2	nM	Bind	In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta	524	7	1	6	5.4	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL122917	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	717	12	2	8	6.8	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F
CHEMBL331507	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	735	12	2	10	6.0	CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL350121	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta	554	16	3	6	5.8	CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1
CHEMBL97332	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	670	11	1	8	5.8	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1
CHEMBL305647	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	701	11	3	7	6.6	CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F
CHEMBL338027	agtr1_human	Human	No	9.7	IC50	=	0.2	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	729	11	2	9	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL293511	agtr1_rabit	Rabbit	Yes	9.7	IC50	=	0.2	nM	Bind	Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta	524	7	1	6	5.4	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL122917	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	717	12	2	8	6.8	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F
CHEMBL331507	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	735	12	2	10	6.0	CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL275552	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	739	12	2	8	7.2	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL334300	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	667	11	2	9	6.3	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL435792	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	747	12	2	8	7.9	CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL334300	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	667	11	2	9	6.3	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL341369	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	743	12	2	9	6.9	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL335778	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta	490	7	1	6	4.8	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1
CHEMBL334300	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	667	11	2	9	6.3	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL341369	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	743	12	2	9	6.9	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL328941	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	638	10	1	8	6.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1
CHEMBL275552	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	739	12	2	8	7.2	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL334300	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	667	11	2	9	6.3	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL435792	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	747	12	2	8	7.9	CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL169967	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	647	12	2	8	6.2	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL334300	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	667	11	2	9	6.3	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL341369	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	743	12	2	9	6.9	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122273	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	751	12	2	8	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL125280	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	741	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL122273	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	751	12	2	8	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL125280	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	741	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL329693	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	652	10	1	8	6.4	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1
CHEMBL94145	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	676	10	1	9	6.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1
CHEMBL122273	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	751	12	2	8	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL125280	agtr1_rabit	Rabbit	No	9.7	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	741	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL122380	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	769	12	2	8	6.7	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1
CHEMBL122380	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	769	12	2	8	6.7	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1
CHEMBL74556	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	693	13	2	8	6.9	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL122380	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	769	12	2	8	6.7	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1
CHEMBL331455	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	705	12	2	9	6.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL338342	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	763	10	2	9	7.1	CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL120199	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	506	11	2	6	5.6	CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL92654	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	546	9	2	6	6.4	CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL331455	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	705	12	2	9	6.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL338342	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	763	10	2	9	7.1	CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL259843	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	693	11	2	9	5.5	CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL74476	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	661	13	2	8	6.5	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL74476	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	661	13	2	8	6.5	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL169488	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	633	13	3	8	5.8	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
CHEMBL74476	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	661	13	2	8	6.5	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL331455	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	705	12	2	9	6.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL338342	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.2	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	763	10	2	9	7.1	CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL341783	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	692	11	1	9	6.3	CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344597	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	781	14	2	8	8.1	CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL125231	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	745	11	2	9	7.1	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl
CHEMBL319730	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	733	13	2	8	7.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL339256	agtr1_human	Human	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.	757	12	2	8	7.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL125231	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	745	11	2	9	7.1	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl
CHEMBL341783	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	692	11	1	9	6.3	CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344597	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	781	14	2	8	8.1	CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL168413	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	619	11	3	8	5.4	CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL169968	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	675	11	2	9	5.4	CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL353615	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	647	14	3	8	6.2	CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1
CHEMBL139041	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	735	13	2	9	7.5	CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338433	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	749	13	2	10	6.4	CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL444065	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	13	2	10	5.5	CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL304946	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	643	13	2	7	7.2	CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C
CHEMBL338433	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	749	13	2	10	6.4	CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL444065	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	715	13	2	10	5.5	CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL95579	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	624	10	1	8	5.8	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1
CHEMBL139041	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	735	13	2	9	7.5	CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL168490	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	605	11	3	8	5.0	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1
CHEMBL339040	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	699	12	2	9	6.2	CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL71388	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	619	14	2	8	6.8	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1
CHEMBL131156	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta	490	8	1	6	4.9	CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1
CHEMBL339040	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	699	12	2	9	6.2	CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL407919	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	702	10	1	7	7.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1
CHEMBL97446	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	674	10	1	8	6.9	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1
CHEMBL339040	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	699	12	2	9	6.2	CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL121872	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	743	12	2	9	6.3	CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339113	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	719	11	2	9	6.8	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL70726	agtr1_human	Human	No	9.6	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	725	15	1	9	7.7	CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
CHEMBL121872	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	743	12	2	9	6.3	CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339113	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	719	11	2	9	6.8	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL334300	agtr1_human	Human	No	9.6	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	667	11	2	9	6.3	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL121872	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	743	12	2	9	6.3	CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339113	agtr1_rabit	Rabbit	No	9.6	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	719	11	2	9	6.8	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL276674	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	701	11	2	9	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	701	11	2	9	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	701	11	2	9	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	701	11	2	9	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	701	11	2	9	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	701	11	2	9	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL343634	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	739	13	2	8	8.1	CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL7550	agtr1_human	Human	Yes	9.5	IC50	=	0.3	nM	Funct	Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL302579	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	768	16	2	9	8.3	CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL303647	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	726	15	1	9	8.1	CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL306340	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	692	17	2	8	6.9	CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL309790	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	733	15	1	9	8.3	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL311018	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	725	15	1	9	7.7	CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1
CHEMBL70867	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	768	16	2	9	8.3	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL71286	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	703	14	1	9	8.2	CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2435824	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis	469	9	2	4	6.4	CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL329099	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	654	10	1	7	6.9	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1
CHEMBL293511	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay	524	7	1	6	5.4	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL58291	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay	544	7	1	7	5.8	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL158795	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	451	7	1	6	5.5	CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1
CHEMBL63998	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	530	11	3	7	4.4	CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL367569	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta	572	2	2	7	5.6	CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.5	IC50	=	0.3	nM	Bind	Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL343634	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	739	13	2	8	8.1	CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL92533	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	648	9	1	8	6.5	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL279629	agtrb_rat	Rat	No	9.5	IC50	=	0.3	nM	Bind	In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtrb_rat	Rat	No	9.5	IC50	=	0.3	nM	Bind	In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL1185398	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	690	10	1	8	7.4	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1
CHEMBL411487	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	690	10	1	8	7.4	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1
CHEMBL316273	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	626	10	1	7	6.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1
CHEMBL332909	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	723	12	2	8	6.7	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL339672	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	723	12	2	8	7.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL352629	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	649	13	3	9	5.0	CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1
CHEMBL302519	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	639	12	2	8	6.8	CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C
CHEMBL279629	agtrb_rat	Rat	No	9.5	IC50	=	0.3	nM	Bind	In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtrb_rat	Rat	No	9.5	IC50	=	0.3	nM	Bind	In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL302519	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	639	12	2	8	6.8	CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C
CHEMBL191	agtr1_human	Human	Yes	9.5	IC50	=	0.3	nM	Bind	Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor	422	8	2	6	4.3	CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl
CHEMBL352947	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.3	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	675	13	2	8	6.8	CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL3640122	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.	568	8	1	8	5.2	CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1
CHEMBL436396	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	715	10	2	9	6.2	CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL2337686	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis	593	11	2	7	5.9	CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2366020	agtr1_human	Human	No	9.5	IC50	=	0.3	nM	Bind	Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis	593	11	2	7	5.9	CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL436396	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	10	2	9	6.2	CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL306638	agtr1_human	Human	No	9.5	IC50	=	0.4	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	735	16	1	9	8.2	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL938	agtr1_human	Human	Yes	9.5	IC50	=	0.4	nM	Bind	Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL93226	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.4	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	512	9	2	6	6.0	CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL436396	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	715	10	2	9	6.2	CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL97394	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	662	10	1	9	5.7	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1
CHEMBL352502	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.4	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	666	12	2	8	6.8	CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL436396	agtr1_rabit	Rabbit	No	9.5	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	10	2	9	6.2	CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL340078	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	791	12	2	8	8.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F
CHEMBL340078	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	791	12	2	8	8.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F
CHEMBL317547	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	626	10	1	7	6.0	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1
CHEMBL320222	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	722	10	1	7	7.4	O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl
CHEMBL125280	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	741	12	2	8	6.9	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL352458	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	656	12	2	9	6.4	CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL340078	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	791	12	2	8	8.0	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F
CHEMBL342492	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	773	13	2	8	8.5	CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340473	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	723	11	2	10	6.9	CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL67801	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	617	16	2	7	7.0	CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1
CHEMBL340473	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	723	11	2	10	6.9	CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL328434	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	680	10	1	7	6.5	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1
CHEMBL342492	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	773	13	2	8	8.5	CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340473	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	723	11	2	10	6.9	CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL122158	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	753	10	2	9	7.3	CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL333224	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	10	2	9	6.3	CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338137	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	767	11	2	9	7.7	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL339722	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL122158	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	753	10	2	9	7.3	CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL333224	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	715	10	2	9	6.3	CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338137	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	767	11	2	9	7.7	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL122158	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	753	10	2	9	7.3	CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL333224	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	715	10	2	9	6.3	CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338137	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	767	11	2	9	7.7	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL330464	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	664	10	1	7	6.5	C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1
CHEMBL169279	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	689	12	2	9	5.8	CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1
CHEMBL284918	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Funct	Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor	501	7	2	8	3.4	CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL34866	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Funct	Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor	501	7	2	8	3.4	CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL307359	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	756	16	2	8	8.8	CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL312301	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	789	16	1	10	7.9	CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL69839	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	678	17	2	8	6.7	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1
CHEMBL408403	agtrb_rat	Rat	Yes	9.4	IC50	=	0.4	nM	Bind	Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1		None	None	None		None
CHEMBL7550	agtrb_rat	Rat	Yes	9.4	IC50	=	0.4	nM	Bind	Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2435823	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis	455	8	2	4	6.1	CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL408403	agtra_rat	Rat	Yes	9.4	IC50	=	0.4	nM	Bind	Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane		None	None	None		None
CHEMBL7550	agtra_rat	Rat	Yes	9.4	IC50	=	0.4	nM	Bind	Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL938	agtr1_human	Human	Yes	9.4	IC50	=	0.4	nM	Bind	Displacement of [125I][Sar, Ile]-ATII from human recombinant AT1 receptor expressed in HEK293 cellsDisplacement of [125I][Sar, Ile]-ATII from human recombinant AT1 receptor expressed in HEK293 cells	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL938	agtr1_human	Human	Yes	9.4	IC50	=	0.4	nM	Bind	Displacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL327191	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	702	10	1	8	6.6	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1
CHEMBL329089	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	638	10	1	8	6.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1
CHEMBL97020	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	712	10	1	7	7.0	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1
CHEMBL444065	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	715	13	2	10	5.5	CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL173643	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta	541	8	2	7	5.5	CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL139325	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	753	12	2	8	7.8	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL141592	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	679	11	1	9	6.4	CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338889	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	719	11	2	9	6.8	CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338434	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.	747	13	2	9	7.6	CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338889	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	719	11	2	9	6.8	CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL316904	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	664	11	1	8	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1
CHEMBL139325	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	753	12	2	8	7.8	CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL141592	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	679	11	1	9	6.4	CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338889	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	719	11	2	9	6.8	CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL342605	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	739	12	2	8	7.2	CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338434	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	747	13	2	9	7.6	CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL1951143	agtr1_rabit	Rabbit	Yes	9.4	IC50	=	0.4	nM	Funct	Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge	501	9	1	7	4.2	CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
CHEMBL334145	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Funct	Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta	478	9	2	6	5.0	CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL334145	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	478	9	2	6	5.0	CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL338434	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	747	13	2	9	7.6	CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL97068	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	630	11	1	8	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1
CHEMBL342605	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	739	12	2	8	7.2	CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338434	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	747	13	2	9	7.6	CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL279629	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL279629	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL279629	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL279629	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL327988	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	688	10	1	8	7.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1
CHEMBL339256	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	757	12	2	8	7.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL341369	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	743	12	2	9	6.9	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL279629	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL354080	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	647	11	3	8	6.1	CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1
CHEMBL121907	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	733	12	2	9	6.6	CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122401	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	815	13	2	8	7.6	CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL284918	agtrb_rat	Rat	No	9.4	IC50	=	0.4	nM	Bind	In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)	501	7	2	8	3.4	CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL34866	agtrb_rat	Rat	No	9.4	IC50	=	0.4	nM	Bind	In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)	501	7	2	8	3.4	CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL121907	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	733	12	2	9	6.6	CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122401	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	815	13	2	8	7.6	CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL339605	agtr1_human	Human	No	9.4	IC50	=	0.4	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	685	11	2	9	6.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL121907	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	733	12	2	9	6.6	CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122401	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.4	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	815	13	2	8	7.6	CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL292150	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.5	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	630	9	1	8	6.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL292150	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.5	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	630	9	1	8	6.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL292150	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.5	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	630	9	1	8	6.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL331455	agtr1_human	Human	No	9.4	IC50	=	0.5	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	705	12	2	9	6.4	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL292150	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.5	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	630	9	1	8	6.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL292150	agtr1_rabit	Rabbit	No	9.4	IC50	=	0.5	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	630	9	1	8	6.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL90011	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	492	9	2	6	5.7	CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL74767	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1	437	9	3	6	3.1	CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C
CHEMBL340367	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1	591	13	1	6	8.6	CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1
CHEMBL4128926	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysis	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12
CHEMBL329942	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	702	10	1	7	7.5	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1
CHEMBL1017	agtr1_human	Human	Yes	9.3	IC50	=	0.5	nM	Bind	Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2
CHEMBL1017	agtr1_human	Human	Yes	9.3	IC50	=	0.5	nM	Bind	Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2
CHEMBL122969	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)	480	13	1	5	5.2	CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1
CHEMBL125725	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)	536	12	2	8	4.6	CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1
CHEMBL307008	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	703	14	1	9	8.2	CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1
CHEMBL72595	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	739	15	1	9	7.9	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F
CHEMBL74573	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	753	16	1	9	8.3	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL25585	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta	536	9	3	7	5.2	CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL90774	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	580	9	2	6	7.3	CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL71253	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	612	13	1	7	7.7	CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.3	IC50	=	0.5	nM	Bind	In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL279629	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL350554	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane	666	11	1	8	6.4	CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL162148	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta	545	10	1	7	5.0	CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL124771	agtr1_human	Human	No	9.3	IC50	=	0.5	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	729	11	2	9	6.6	CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL338888	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	685	11	2	9	6.4	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL67921	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	605	13	2	8	6.4	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1
CHEMBL338888	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	685	11	2	9	6.4	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338888	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	685	11	2	9	6.4	CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL281386	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	484	9	2	6	4.9	CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL263191	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	665	13	3	8	5.2	CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F
CHEMBL124903	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	719	11	2	9	6.2	CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL123084	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1	533	11	1	5	7.4	CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl
CHEMBL124903	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	719	11	2	9	6.2	CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL124903	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	719	11	2	9	6.2	CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.3	IC50	=	0.5	nM	Bind	Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550	agtr1_rabit	Rabbit	Yes	9.3	IC50	=	0.5	nM	Funct	In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.	409	5	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL263452	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.5	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	683	10	2	7	6.4	CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1
CHEMBL332897	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Funct	Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response	512	9	2	6	6.1	CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL332897	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	512	9	2	6	6.1	CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL279629	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparation	634	10	1	7	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL339004	agtr1_human	Human	No	9.3	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	751	14	2	8	7.2	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL353980	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane	681	12	3	8	7.2	CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL342843	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	649	10	2	8	6.1	CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344387	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	683	10	2	8	6.5	CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL122157	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	701	9	2	9	5.8	CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122157	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.	701	9	2	9	5.8	CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL316655	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	612	10	1	7	5.6	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1
CHEMBL330165	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	648	10	1	7	6.5	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1
CHEMBL339722	agtr1_human	Human	No	9.3	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	715	13	2	10	6.1	CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL342843	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	649	10	2	8	6.1	CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344387	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	683	10	2	8	6.5	CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL122157	agtr1_rabit	Rabbit	No	9.3	IC50	=	0.6	nM	Bind	Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor	701	9	2	9	5.8	CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL71125	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	787	16	1	9	8.5	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F
CHEMBL73876	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	663	11	2	8	5.9	CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F
CHEMBL73876	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	663	11	2	8	5.9	CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F
CHEMBL938	agtr1_human	Human	Yes	9.2	IC50	=	0.6	nM	Bind	Inhibition of human angiotensin II AT1 receptorInhibition of human angiotensin II AT1 receptor	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL26614	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta	564	9	1	7	5.5	CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL316482	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	630	12	1	8	6.3	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1
CHEMBL122443	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)	536	12	2	8	4.6	CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1
CHEMBL124925	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)	534	12	1	6	5.9	CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1
CHEMBL341295	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)	520	12	1	6	5.6	CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1
CHEMBL304065	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	679	13	1	9	6.7	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1
CHEMBL419073	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	772	16	2	8	7.8	CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL71220	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	753	16	1	9	8.3	CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL72099	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	727	16	1	9	8.6	CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1
CHEMBL74236	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	731	15	1	9	8.8	CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL938	agtr1_human	Human	Yes	9.2	IC50	=	0.6	nM	Bind	Binding affinity to human angiotensin AT1 receptor by radioligand displacement assayBinding affinity to human angiotensin AT1 receptor by radioligand displacement assay	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL92472	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	546	9	2	6	6.7	CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL307757	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	598	12	1	7	7.4	CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL448476	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	633	10	2	7	8.3	CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL71925	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	633	10	2	7	8.3	CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL97465	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	710	11	1	7	7.9	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1
CHEMBL71925	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1	633	10	2	7	8.3	CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL313868	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta	735	13	2	8	7.1	CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL74442	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	665	11	2	8	6.1	CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL344811	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	747	14	1	8	7.4	CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344811	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	747	14	1	8	7.4	CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL93886	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	554	10	2	6	7.0	CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL1182768	agtr1_rabit	Rabbit	Yes	9.2	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	654	10	1	8	6.6	CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F
CHEMBL321367	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	634	10	1	7	5.6	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1
CHEMBL339040	agtr1_human	Human	No	9.2	IC50	=	0.6	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	699	12	2	9	6.2	CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL62269	agtrb_rat	Rat	No	9.2	IC50	=	0.7	nM	Bind	Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex	473	8	1	8	1.9	CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL35381	agtrb_rat	Rat	No	9.2	IC50	=	0.7	nM	Bind	In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)	511	7	2	8	3.8	CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1
CHEMBL938	agtr1_human	Human	Yes	9.2	IC50	=	0.7	nM	Bind	Displacement of radiolabeled saralasin from human AT1 receptorDisplacement of radiolabeled saralasin from human AT1 receptor	911	25	12	12	-2.5	C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL120457	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.7	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	532	8	2	6	6.0	CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL98453	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.7	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	796	10	1	8	7.8	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1
CHEMBL336180	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.7	nM	Bind	In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta	488	7	1	6	4.5	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1
CHEMBL329858	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.7	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	652	10	1	7	6.4	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1
CHEMBL1016	agtr1_human	Human	Yes	9.2	IC50	=	0.7	nM	Bind	Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O
CHEMBL338740	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.7	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	532	8	2	6	6.3	CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL126111	agtr1_human	Human	No	9.2	IC50	=	0.7	nM	Bind	Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)	520	12	1	6	5.6	CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1
CHEMBL4278280	agtr1_human	Human	No	9.2	IC50	=	0.7	nM	Funct	Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay	543	9	1	7	4.9	CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1
CHEMBL344407	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.7	nM	Bind	Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings	445	5	1	6	4.2	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1
CHEMBL2435829	agtr1_human	Human	No	9.2	IC50	=	0.7	nM	Bind	Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis	457	7	2	5	5.9	CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL344407	agtr1_rabit	Rabbit	No	9.2	IC50	=	0.7	nM	Bind	Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.	445	5	1	6	4.2	CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1
CHEMBL259843	agtr1_human	Human	No	9.2	IC50	=	0.7	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane	693	11	2	9	5.5	CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL319353	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.7	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	702	10	1	7	7.5	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1
CHEMBL321363	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.7	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	718	10	1	8	7.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1
CHEMBL122273	agtr1_human	Human	No	9.1	IC50	=	0.7	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	751	12	2	8	6.6	CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL408403	agtr1_human	Human	Yes	9.1	IC50	=	0.7	nM	Bind	Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting		None	None	None		None
CHEMBL306361	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.7	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	635	11	3	8	5.2	CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1
CHEMBL419483	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.7	nM	Bind	Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin	526	10	1	10	4.2	CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL70100	agtr1_human	Human	No	9.1	IC50	=	0.7	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	769	16	1	9	8.4	CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1
CHEMBL122224	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.7	nM	Bind	Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1	513	11	1	5	7.1	CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1
CHEMBL419483	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.7	nM	Funct	In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)	526	10	1	10	4.2	CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL330463	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.7	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	664	11	1	8	6.2	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1
CHEMBL339113	agtr1_human	Human	No	9.1	IC50	=	0.7	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	719	11	2	9	6.8	CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL25585	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro	536	9	3	7	5.2	CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL122017	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1	533	11	1	5	7.4	CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1
CHEMBL409058	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	616	12	1	8	5.0	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1
CHEMBL97557	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	659	10	1	8	6.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1
CHEMBL340632	agtr1_human	Human	No	9.1	IC50	=	0.8	nM	Bind	In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.	713	13	2	9	6.6	CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL3640129	agtr1_human	Human	No	9.1	IC50	=	0.8	nM	Bind	Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.	612	9	1	10	4.9	CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1
CHEMBL1667998	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings	470	8	1	5	5.8	CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
CHEMBL94002	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	546	9	2	6	6.7	CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL76821	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane	663	10	2	8	6.1	CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F
CHEMBL2425239	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes	626	9	1	11	4.0	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1
CHEMBL19018	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1	519	8	1	7	5.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL19018	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	519	8	1	7	5.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL19018	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation	519	8	1	7	5.3	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL306435	agtr1_human	Human	No	9.1	IC50	=	0.8	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	699	14	1	10	6.9	CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1
CHEMBL74069	agtr1_human	Human	No	9.1	IC50	=	0.8	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	731	15	1	9	8.8	CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL74514	agtr1_human	Human	No	9.1	IC50	=	0.8	nM	Bind	Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1	753	16	1	9	8.5	CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL315104	agtrb_rat	Rat	No	9.1	IC50	=	0.8	nM	Bind	Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1	423	6	1	6	4.9	CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL337086	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings	520	5	1	6	6.3	CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1
CHEMBL278305	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1	628	11	1	8	5.1	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1
CHEMBL278977	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1	654	10	1	8	5.0	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1
CHEMBL315104	agtra_rat	Rat	No	9.1	IC50	=	0.8	nM	Bind	Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane	423	6	1	6	4.9	CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL333800	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Funct	Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1	508	10	2	7	5.4	CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL335722	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Funct	In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.	595	11	1	7	6.1	CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1
CHEMBL337086	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Funct	In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.	520	5	1	6	6.3	CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1
CHEMBL449648	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane	524	7	1	6	5.3	CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL327563	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	612	10	1	7	5.7	CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1
CHEMBL329759	agtr1_rabit	Rabbit	No	9.1	IC50	=	0.8	nM	Bind	In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII	626	9

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