Ligand source activities (1 row/activity)





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DOI

16133225 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
16133225 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
172198 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
2504 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
45266664 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
5272 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
CHEMBL408403 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
DB11842 419 52 None -5 4 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL None None None None 10.1021/acs.jmedchem.5b01495
127030943 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127030943 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787243 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787375 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787700 139195 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
16133225 419 52 None -6 4 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198 419 52 None -6 4 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 419 52 None -6 4 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 419 52 None -6 4 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 419 52 None -6 4 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 419 52 None -6 4 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 419 52 None -6 4 Rat 8.9 pEC50 = 8.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
127029976 139217 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139217 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139217 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029976 139217 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786145 139217 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787767 139217 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
155564502 175260 0 None 2 2 Rat 7.0 pEC50 = 7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4572408 175260 0 None 2 2 Rat 7.0 pEC50 = 7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
11943 3875 0 None 14 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
145925549 3875 0 None 14 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4438122 3875 0 None 14 2 Rat 8.0 pEC50 = 8.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155558059 174683 0 None -5 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174683 0 None -5 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
155541440 173019 0 None -1 2 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173019 0 None -1 2 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
155541295 173011 0 None 4 2 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4518318 173011 0 None 4 2 Rat 7.9 pEC50 = 7.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155540639 172933 0 None -1 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4516768 172933 0 None -1 2 Rat 5.9 pEC50 = 5.9 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL2028943 209135 0 None -1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155553930 175441 0 None -1 2 Rat 4.8 pEC50 = 4.8 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4576650 175441 0 None -1 2 Rat 4.8 pEC50 = 4.8 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155540033 172890 0 None -2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172890 0 None -2 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
127029977 139218 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 139218 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 139218 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127029977 139218 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3786986 139218 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
CHEMBL3787768 139218 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/acs.jmedchem.5b01495
127031545 139196 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 139196 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 139196 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
127031545 139196 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787379 139196 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
CHEMBL3787701 139196 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
ChEMBL 1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C 10.1021/acs.jmedchem.5b01495
16133225 419 52 None -5 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
172198 419 52 None -5 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
2504 419 52 None -5 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
45266664 419 52 None -5 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
5272 419 52 None -5 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL408403 419 52 None -5 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
DB11842 419 52 None -5 4 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155541440 173019 0 None 1 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
CHEMBL4518530 173019 0 None 1 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O nan
10533900 175969 8 None 10 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175969 8 None 10 2 Rat 7.7 pEC50 = 7.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
155556507 174486 0 None 2 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4554466 174486 0 None 2 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155563538 175300 0 None -1 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
CHEMBL4573250 175300 0 None -1 2 Rat 6.7 pEC50 = 6.7 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O nan
155559104 174806 0 None 2 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
CHEMBL4562270 174806 0 None 2 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
155554865 174354 0 None 2 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4551317 174354 0 None 2 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
155540328 172901 0 None -3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172901 0 None -3 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155553479 174178 0 None 3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4547423 174178 0 None 3 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
155558003 174693 0 None 1 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4559421 174693 0 None 1 2 Rat 5.6 pEC50 = 5.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155547428 173615 0 None -22 2 Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4533618 173615 0 None -22 2 Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155566196 175746 0 None -5 2 Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4583284 175746 0 None -5 2 Rat 4.6 pEC50 = 4.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
155558428 174729 0 None 1 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
CHEMBL4560224 174729 0 None 1 2 Rat 7.6 pEC50 = 7.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C nan
11944 3876 0 None 4 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155552190 3876 0 None 4 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL4544228 3876 0 None 4 2 Rat 6.6 pEC50 = 6.6 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
CHEMBL77838 215878 5 None -1 2 Rat 8.5 pEC50 = 8.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O nan
155552475 174052 0 None 9 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174052 0 None 9 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155542907 173177 0 None 3 2 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL4522038 173177 0 None 3 2 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C nan
CHEMBL2028943 209135 0 None 1 2 Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155552475 174052 0 None -9 2 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
CHEMBL4543860 174052 0 None -9 2 Rat 6.5 pEC50 = 6.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O nan
155556530 174511 0 None 2 2 Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
CHEMBL4555119 174511 0 None 2 2 Rat 7.5 pEC50 = 7.5 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C nan
155561376 175675 0 None 12 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
CHEMBL4581718 175675 0 None 12 2 Rat 6.4 pEC50 = 6.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O nan
155541125 172965 0 None 6 2 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
CHEMBL4517561 172965 0 None 6 2 Rat 7.4 pEC50 = 7.4 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O nan
24892627 55653 5 None -5 2 Human 4.2 pEC50 = 4.2 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1460676 55653 5 None -5 2 Human 4.2 pEC50 = 4.2 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
CHEMBL1621632 55653 5 None -5 2 Human 4.2 pEC50 = 4.2 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 nan
155558059 174683 0 None 5 2 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL4559239 174683 0 None 5 2 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C nan
CHEMBL938 215907 28 None -10 4 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C nan
CHEMBL312754 211110 18 None 1 2 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O nan
154573825 175989 9 None 8 2 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175989 9 None 8 2 Rat 8.2 pEC50 = 8.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155560463 175040 0 None -1 2 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
CHEMBL4567667 175040 0 None -1 2 Rat 7.2 pEC50 = 7.2 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C nan
155553003 174076 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174076 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
10533900 175969 8 None -10 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL4588454 175969 8 None -10 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O nan
CHEMBL2392353 210414 6 None -50 3 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None None nan
155553098 174110 0 None 22 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
CHEMBL4545153 174110 0 None 22 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C nan
1588251 59277 10 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
CHEMBL1704271 59277 10 None - 1 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
ChEMBL 436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O nan
155540328 172901 0 None 3 2 Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
CHEMBL4516066 172901 0 None 3 2 Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O nan
155540033 172890 0 None 2 2 Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
CHEMBL4515768 172890 0 None 2 2 Rat 7.1 pEC50 = 7.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O nan
155539838 172895 0 None 1 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL4515848 172895 0 None 1 2 Rat 8.1 pEC50 = 8.1 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O nan
CHEMBL2370909 209948 0 None 7 2 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O nan
155558784 174776 0 None -2 2 Rat 6.0 pEC50 = 6.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
CHEMBL4561366 174776 0 None -2 2 Rat 6.0 pEC50 = 6.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O nan
154573825 175989 9 None -8 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
CHEMBL4588946 175989 9 None -8 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C nan
155553003 174076 0 None -1 2 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
CHEMBL4544308 174076 0 None -1 2 Rat 7.0 pEC50 = 7.0 Functional
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
ChEMBL 791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C nan
3025727 184080 10 None 10000 2 Rabbit 10.3 pIC50 = 10.3 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL48242 184080 10 None 10000 2 Rabbit 10.3 pIC50 = 10.3 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971704 112385 0 None - 1 Rabbit 9.7 pIC50 = 9.7 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329616 112385 0 None - 1 Rabbit 9.7 pIC50 = 9.7 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
133031 100859 21 None 1 3 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
CHEMBL293511 100859 21 None 1 3 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 10.1021/jm1013693
9892554 100194 6 None - 1 Rabbit 9.7 pIC50 = 9.7 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 510 9 1 8 3.5 CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL288246 100194 6 None - 1 Rabbit 9.7 pIC50 = 9.7 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 510 9 1 8 3.5 CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmc.2010.10.043
14971715 168236 0 None - 1 Rabbit 9.7 pIC50 = 9.7 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 10 2 6 5.4 CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL433646 168236 0 None - 1 Rabbit 9.7 pIC50 = 9.7 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 10 2 6 5.4 CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971716 14524 0 None - 1 Rabbit 9.6 pIC50 = 9.6 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 11 2 6 5.6 CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120199 14524 0 None - 1 Rabbit 9.6 pIC50 = 9.6 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 11 2 6 5.6 CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971706 207209 0 None - 1 Rabbit 9.6 pIC50 = 9.6 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92654 207209 0 None - 1 Rabbit 9.6 pIC50 = 9.6 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
183134 204844 17 None -4 7 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm1013693
CHEMBL7550 204844 17 None -4 7 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm1013693
14971698 207293 0 None - 1 Rabbit 9.5 pIC50 = 9.5 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93226 207293 0 None - 1 Rabbit 9.5 pIC50 = 9.5 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9827346 99737 4 None 1 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
CHEMBL284918 99737 4 None 1 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
CHEMBL34866 99737 4 None 1 2 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 10.1016/j.bmc.2010.10.043
9870652 70892 75 None 15 2 Rabbit 9.4 pIC50 = 9.4 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951143 70892 75 None 15 2 Rabbit 9.4 pIC50 = 9.4 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971720 114822 0 None - 1 Rabbit 9.4 pIC50 = 9.4 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL334145 114822 0 None - 1 Rabbit 9.4 pIC50 = 9.4 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971720 114822 0 None - 1 Rabbit 9.4 pIC50 = 9.4 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL334145 114822 0 None - 1 Rabbit 9.4 pIC50 = 9.4 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971705 206749 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 9 2 6 5.7 CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL90011 206749 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 492 9 2 6 5.7 CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10325927 206886 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 580 9 2 6 7.3 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL90774 206886 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 580 9 2 6 7.3 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971714 99190 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 484 9 2 6 4.9 CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL281386 99190 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 484 9 2 6 4.9 CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
183134 204844 17 None -2 7 Rabbit 9.3 pIC50 = 9.3 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a013
183134 204844 17 None -2 7 Rabbit 9.3 pIC50 = 9.3 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a014
CHEMBL7550 204844 17 None -2 7 Rabbit 9.3 pIC50 = 9.3 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a013
CHEMBL7550 204844 17 None -2 7 Rabbit 9.3 pIC50 = 9.3 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00078a014
14971639 114132 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
CHEMBL332897 114132 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/j.bmc.2010.10.043
14971639 114132 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL332897 114132 0 None - 1 Rabbit 9.3 pIC50 = 9.3 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971702 207179 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92472 207179 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971710 207398 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 554 10 2 6 7.0 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93886 207398 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 554 10 2 6 7.0 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971717 14582 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.0 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120457 14582 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.0 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10369813 116980 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.3 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL338740 116980 0 None - 1 Rabbit 9.2 pIC50 = 9.2 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 532 8 2 6 6.3 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
142534045 166478 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 543 9 1 7 4.9 CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4278280 166478 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 543 9 1 7 4.9 CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956763 163397 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL419483 163397 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971701 207419 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL94002 207419 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 546 9 2 6 6.7 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971708 114594 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 508 10 2 7 5.4 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL333800 114594 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 508 10 2 7 5.4 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10393717 116099 0 None 524 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL335722 116099 0 None 524 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
9914666 116670 0 None 3388 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL337086 116670 0 None 3388 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 10.1021/jm00078a013
14956739 206302 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87074 206302 0 None - 1 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 496 9 1 9 4.2 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
192567 116652 6 None 223 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
CHEMBL337007 116652 6 None 223 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 581 10 1 7 5.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 10.1021/jm00078a014
10140613 106096 0 None 3 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313371 106096 0 None 3 2 Rabbit 9.1 pIC50 = 9.1 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 10 1 7 4.5 CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956772 105947 0 None - 1 Rabbit 9.0 pIC50 = 9.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL312913 105947 0 None - 1 Rabbit 9.0 pIC50 = 9.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 510 10 1 9 4.6 CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
192345 26236 6 None 12022 2 Rabbit 9.0 pIC50 = 9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
CHEMBL135775 26236 6 None 12022 2 Rabbit 9.0 pIC50 = 9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 496 6 1 7 5.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 10.1021/jm00078a013
10326140 116651 0 None 2884 2 Rabbit 9.0 pIC50 = 9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
CHEMBL337006 116651 0 None 2884 2 Rabbit 9.0 pIC50 = 9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 593 11 1 7 5.9 C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 10.1021/jm00078a014
9807766 70884 0 None - 1 Rabbit 9.0 pIC50 = 9.0 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 8 4.0 CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951136 70884 0 None - 1 Rabbit 9.0 pIC50 = 9.0 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 555 9 1 8 4.0 CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
60770 169499 17 None - 1 Rabbit 9.0 pIC50 = 9.0 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 8 2 6 5.1 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL443269 169499 17 None - 1 Rabbit 9.0 pIC50 = 9.0 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 506 8 2 6 5.1 CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
142534141 167177 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4291216 167177 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 557 9 1 7 5.3 CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14956757 67593 0 None 831 2 Rabbit 8.9 pIC50 = 8.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL19018 67593 0 None 831 2 Rabbit 8.9 pIC50 = 8.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971700 207457 0 None - 1 Rabbit 8.9 pIC50 = 8.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL94221 207457 0 None - 1 Rabbit 8.9 pIC50 = 8.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 512 9 2 6 6.0 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
9871638 70893 0 None - 1 Rabbit 8.9 pIC50 = 8.9 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 529 11 1 7 5.0 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951144 70893 0 None - 1 Rabbit 8.9 pIC50 = 8.9 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 529 11 1 7 5.0 CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
44320012 167923 0 None - 1 Rabbit 8.9 pIC50 = 8.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL431411 167923 0 None - 1 Rabbit 8.9 pIC50 = 8.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 9 1 7 5.4 CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
155542482 173127 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 487 9 1 6 5.5 CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.12.043
CHEMBL4520827 173127 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 487 9 1 6 5.5 CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2018.12.043
44213341 70877 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 511 9 1 7 4.0 CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951129 70877 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 511 9 1 7 4.0 CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
137532858 167090 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 517 9 1 7 4.4 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4289788 167090 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 517 9 1 7 4.4 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
14971719 114792 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 470 8 2 6 4.5 CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL333978 114792 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 470 8 2 6 4.5 CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971711 16554 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 479 9 2 7 4.7 CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL123767 16554 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 479 9 2 7 4.7 CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971707 207336 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 523 10 2 8 5.3 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93547 207336 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 523 10 2 8 5.3 CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44213349 70883 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 527 9 1 8 3.2 CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951135 70883 0 None - 1 Rabbit 8.8 pIC50 = 8.8 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 527 9 1 8 3.2 CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
20081627 92170 0 None 1 2 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/j.bmc.2010.10.043
CHEMBL24224 92170 0 None 1 2 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
ChEMBL 502 6 2 7 4.7 CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 10.1016/j.bmc.2010.10.043
145981239 166609 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 9 1 7 5.7 CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4280574 166609 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
ChEMBL 571 9 1 7 5.7 CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
131654 206403 12 None 1 2 Rabbit 8.7 pIC50 = 8.7 Functional
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87778 206403 12 None 1 2 Rabbit 8.7 pIC50 = 8.7 Functional
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane using 0.2% bovine serum albumin (BSA)
ChEMBL 431 10 1 7 4.1 CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956781 206173 0 None - 1 Rabbit 8.7 pIC50 = 8.7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 443 8 1 7 4.4 CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86314 206173 0 None - 1 Rabbit 8.7 pIC50 = 8.7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 443 8 1 7 4.4 CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
9845644 206433 0 None 5 2 Rabbit 8.7 pIC50 = 8.7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87964 206433 0 None 5 2 Rabbit 8.7 pIC50 = 8.7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 431 9 1 7 4.3 CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1610 2347 95 None -19 11 Rabbit 8.0 pIC50 = 8 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
3941 2347 95 None -19 11 Rabbit 8.0 pIC50 = 8 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
3961 2347 95 None -19 11 Rabbit 8.0 pIC50 = 8 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
590 2347 95 None -19 11 Rabbit 8.0 pIC50 = 8 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
CHEMBL191 2347 95 None -19 11 Rabbit 8.0 pIC50 = 8 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
DB00678 2347 95 None -19 11 Rabbit 8.0 pIC50 = 8 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl 10.1021/jm0603163
10095589 115519 0 None 851 2 Rabbit 8.0 pIC50 = 8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL335289 115519 0 None 851 2 Rabbit 8.0 pIC50 = 8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 456 8 1 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
19939399 106164 0 None - 1 Rabbit 8.0 pIC50 = 8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 609 11 2 10 5.2 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313696 106164 0 None - 1 Rabbit 8.0 pIC50 = 8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 609 11 2 10 5.2 CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10222835 206145 0 None 2 2 Rabbit 8.0 pIC50 = 8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86084 206145 0 None 2 2 Rabbit 8.0 pIC50 = 8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 403 8 1 7 3.3 CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
142533975 167048 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
CHEMBL4288964 167048 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by beta-arrestin recruitment assay
ChEMBL 571 10 1 7 5.7 CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 10.1016/j.bmcl.2018.08.036
44348352 16528 0 None 1 2 Rabbit 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
CHEMBL123713 16528 0 None 1 2 Rabbit 7.0 pIC50 = 7 Functional
Antagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit adrenal cortex assessed as inhibition of angiotensin 2-induced contractile response
ChEMBL 459 8 1 6 4.5 CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC 10.1016/j.bmc.2010.10.043
14971675 206969 0 None - 1 Rabbit 7.0 pIC50 = 7 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL91287 206969 0 None - 1 Rabbit 7.0 pIC50 = 7 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
10048220 26189 0 None 109 2 Rabbit 7.0 pIC50 = 7 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
CHEMBL135704 26189 0 None 109 2 Rabbit 7.0 pIC50 = 7 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 428 7 2 5 5.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 10.1021/jm00078a014
14956760 165500 0 None - 1 Rabbit 7.0 pIC50 = 7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL424053 165500 0 None - 1 Rabbit 7.0 pIC50 = 7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 466 8 2 8 3.9 CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956777 206329 0 None - 1 Rabbit 7.0 pIC50 = 7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 415 8 1 7 3.6 CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87276 206329 0 None - 1 Rabbit 7.0 pIC50 = 7 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 415 8 1 7 3.6 CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
164611301 185018 0 None -1 2 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
CHEMBL4854916 185018 0 None -1 2 Human 5.0 pIC50 = 5 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
1240113 29470 7 None -3 3 Human 5.0 pIC50 = 5 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 265 3 0 2 4.8 Cc1cccc(CSc2cccc3cccnc23)c1 nan
CHEMBL1384550 29470 7 None -3 3 Human 5.0 pIC50 = 5 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 265 3 0 2 4.8 Cc1cccc(CSc2cccc3cccnc23)c1 nan
164622816 185874 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 10.1021/acsmedchemlett.1c00240
CHEMBL4868159 185874 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 416 7 1 5 3.9 CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 10.1021/acsmedchemlett.1c00240
5411796 71927 9 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 4 1 3 3.9 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl nan
CHEMBL1972216 71927 9 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 335 4 1 3 3.9 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl nan
5740287 40195 8 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 6 0 7 4.3 COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 nan
CHEMBL1480264 40195 8 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 6 0 7 4.3 COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 nan
5738419 48454 14 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 1 3 4.2 Oc1cccc2ccc(/C=C/c3cccs3)nc12 nan
CHEMBL1555793 48454 14 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 253 2 1 3 4.2 Oc1cccc2ccc(/C=C/c3cccs3)nc12 nan
659124 38437 8 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 7 1 7 4.4 CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 nan
CHEMBL1463829 38437 8 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 7 1 7 4.4 CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 nan
1183382 23505 15 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 367 5 0 7 3.3 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O nan
CHEMBL1333737 23505 15 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 367 5 0 7 3.3 COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O nan
1334532 36926 7 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 365 2 3 4 3.0 Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 nan
CHEMBL1451169 36926 7 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 365 2 3 4 3.0 Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 nan
10257526 112372 0 None - 1 Rabbit 7.0 pIC50 = 7.0 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL329541 112372 0 None - 1 Rabbit 7.0 pIC50 = 7.0 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 574 10 1 7 7.1 CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
5952109 72046 7 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 4 1 5 5.6 CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 nan
CHEMBL1976317 72046 7 None -1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 389 4 1 5 5.6 CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 nan
2236648 28705 11 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 355 2 3 3 3.0 CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 nan
CHEMBL1377849 28705 11 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 355 2 3 3 3.0 CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 nan
6154033 108481 5 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 3 3.4 O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 nan
CHEMBL3199403 108481 5 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 4 1 3 3.4 O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 nan
4116022 50995 6 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 368 10 1 9 3.4 CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 nan
CHEMBL1578324 50995 6 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 368 10 1 9 3.4 CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 nan
19939367 105950 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL312921 105950 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956804 105999 0 None 1 2 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL313222 105999 0 None 1 2 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 11 1 7 4.9 CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956792 106766 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314447 106766 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956754 157385 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL407827 157385 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 10 1 7 5.9 CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956787 206347 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 461 9 1 9 3.0 CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87363 206347 0 None - 1 Rabbit 8.0 pIC50 = 8.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 461 9 1 9 3.0 CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44373246 168267 0 None - 1 Bovine 8.0 pIC50 = 8.0 Functional
In vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortexIn vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortex
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1021/jm9504722
CHEMBL433895 168267 0 None - 1 Bovine 8.0 pIC50 = 8.0 Functional
In vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortexIn vitro antagonistic potency against Angiotensin II receptor, type 1 in rat adrenal cortex
ChEMBL 435 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 10.1021/jm9504722
14956796 205799 0 None - 1 Rabbit 7.0 pIC50 = 7.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL83182 205799 0 None - 1 Rabbit 7.0 pIC50 = 7.0 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.1 CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
10094520 24758 0 None 11 2 Rabbit 6.0 pIC50 = 6.0 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
CHEMBL134433 24758 0 None 11 2 Rabbit 6.0 pIC50 = 6.0 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C 10.1021/jm00078a013
3504072 33630 12 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 299 2 2 3 2.1 O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 nan
CHEMBL1421427 33630 12 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 299 2 2 3 2.1 O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 nan
869765 38588 8 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 322 5 2 6 3.1 COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC nan
CHEMBL1464917 38588 8 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 322 5 2 6 3.1 COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC nan
16446215 47607 9 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 467 7 1 6 4.3 Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 nan
CHEMBL1546607 47607 9 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 467 7 1 6 4.3 Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 nan
5295671 35516 10 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 2 0 6 2.1 CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 nan
CHEMBL1438779 35516 10 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 314 2 0 6 2.1 CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 nan
1653161 40325 13 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 3 3 5 1.2 COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 nan
CHEMBL1481281 40325 13 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 319 3 3 5 1.2 COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 nan
14956759 206102 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85704 206102 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 495 9 2 8 4.0 CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
5335659 108463 7 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 nan
CHEMBL3199216 108463 7 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 257 3 1 3 2.4 C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 nan
16446684 42995 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 405 5 1 5 3.5 O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl nan
CHEMBL1504077 42995 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 405 5 1 5 3.5 O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl nan
2426231 38123 6 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 3 3 3 5.3 Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
CHEMBL1461119 38123 6 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 394 3 3 3 5.3 Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl nan
53319274 57600 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
CHEMBL1668000 57600 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cellsAntagonist activity at angiotensin AT1 receptor in human PLC-PRF5 cells
ChEMBL 559 9 1 7 4.2 CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O 10.1016/j.bmc.2010.10.043
10027714 115437 0 None 398 2 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
CHEMBL335066 115437 0 None 398 2 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 470 9 1 5 6.0 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 10.1021/jm00078a014
14956793 206308 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87129 206308 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 479 9 1 7 4.6 CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956791 206341 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 459 8 2 8 3.4 CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87341 206341 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 459 8 2 8 3.4 CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956798 206409 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87798 206409 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 523 10 1 9 4.0 CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14951059 206429 0 None -1 2 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87942 206429 0 None -1 2 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 493 10 1 8 4.2 CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
11744670 115254 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 453 5 0 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 10.1021/jm00078a013
CHEMBL334775 115254 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 453 5 0 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 10.1021/jm00078a013
14956742 206328 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87275 206328 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 485 8 1 7 4.9 CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
5187118 51862 6 None -5 4 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
CHEMBL1585527 51862 6 None -5 4 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 338 3 1 3 4.8 Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 nan
2313746 52120 1 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl nan
CHEMBL1587672 52120 1 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl nan
6917582 45673 1 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 nan
CHEMBL1529805 45673 1 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 378 3 1 5 3.1 COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 nan
665535 44994 6 None -1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 7 1 9 1.8 COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
CHEMBL1523699 44994 6 None -1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 7 1 9 1.8 COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 nan
2812568 37207 5 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 3 2 3 3.8 O=C(NNc1ccc(Cl)cc1)c1sccc1Cl nan
CHEMBL1453309 37207 5 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 286 3 2 3 3.8 O=C(NNc1ccc(Cl)cc1)c1sccc1Cl nan
921731 52176 7 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 0 7 2.1 O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1588194 52176 7 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 0 7 2.1 O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
6173110 108160 4 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 5 1 4 3.3 COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 nan
CHEMBL3196139 108160 4 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 331 5 1 4 3.3 COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 nan
2351493 49785 2 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 4 1 3 3.3 O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 nan
CHEMBL1567294 49785 2 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 301 4 1 3 3.3 O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 nan
11467216 122602 0 None - 1 Rabbit 5.9 pIC50 = 5.9 Functional
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 567 15 1 10 5.2 CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
CHEMBL360220 122602 0 None - 1 Rabbit 5.9 pIC50 = 5.9 Functional
Vasorelaxing potency was determinedVasorelaxing potency was determined
ChEMBL 567 15 1 10 5.2 CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm049681p
135457059 51015 23 None -2 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 1 5 4.2 Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 nan
CHEMBL1578482 51015 23 None -2 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 1 5 4.2 Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 nan
2303647 28426 10 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 3 2 4 3.1 NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 nan
CHEMBL1375248 28426 10 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 262 3 2 4 3.1 NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 nan
11328757 205967 0 None -1 2 Rabbit 7.9 pIC50 = 7.9 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm0603163
CHEMBL84573 205967 0 None -1 2 Rabbit 7.9 pIC50 = 7.9 Functional
Antagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contractionAntagonist activity against AT1 receptor assessed as inhibition of Ang2-induced rabbit aortic strip contraction
ChEMBL 464 6 1 5 6.3 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 10.1021/jm0603163
9896251 98773 0 None 1 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at type 1 angiotensin 2 receptorAntagonist activity at type 1 angiotensin 2 receptor
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
CHEMBL278176 98773 0 None 1 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at type 1 angiotensin 2 receptorAntagonist activity at type 1 angiotensin 2 receptor
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
9958963 207232 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL92821 207232 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 540 10 1 7 6.5 CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14971680 207371 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 10 1 7 6.1 CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL93735 207371 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 520 10 1 7 6.1 CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
57391456 70891 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 8 4.4 CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
CHEMBL1951142 70891 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
ChEMBL 569 10 1 8 4.4 CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1016/j.bmcl.2011.12.116
14971687 14813 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120716 14813 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 430 9 2 6 4.4 CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
14956812 106672 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 463 8 1 7 4.1 O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314333 106672 0 None - 1 Rabbit 6.9 pIC50 = 6.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 463 8 1 7 4.1 O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
793621 26580 8 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 1 1 5 3.3 CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 nan
CHEMBL1361034 26580 8 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 281 1 1 5 3.3 CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 nan
2420694 33050 6 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.8 Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 nan
CHEMBL1416497 33050 6 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 360 3 3 3 4.8 Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 nan
1477595 44659 29 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 3 0 5 1.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 nan
CHEMBL1520753 44659 29 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 264 3 0 5 1.8 O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 nan
1336836 33009 10 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 5 0 6 4.5 Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 nan
CHEMBL1416155 33009 10 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 398 5 0 6 4.5 Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 nan
135489943 107866 3 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 387 9 2 5 4.0 CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O nan
CHEMBL3192625 107866 3 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 387 9 2 5 4.0 CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O nan
1139588 38361 11 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 5 0 6 3.2 O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1463168 38361 11 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 363 5 0 6 3.2 O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 nan
6873170 108465 8 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 249 2 1 3 1.2 S=C(N/N=C/c1ccccc1)N1CCOCC1 nan
CHEMBL3199234 108465 8 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 249 2 1 3 1.2 S=C(N/N=C/c1ccccc1)N1CCOCC1 nan
804442 53827 56 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 4 1 2 3.7 O=C(CNc1ccc(Br)cc1)c1ccccc1 nan
CHEMBL1604367 53827 56 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 289 4 1 2 3.7 O=C(CNc1ccc(Br)cc1)c1ccccc1 nan
929469 46562 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 5 0 7 1.4 O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1537991 46562 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 5 0 7 1.4 O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 nan
3244543 199496 25 None -3 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 188 0 2 3 2.1 Cc1cc(C)c2ccc(N)nc2c1O nan
CHEMBL591834 199496 25 None -3 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 188 0 2 3 2.1 Cc1cc(C)c2ccc(N)nc2c1O nan
43001 52785 26 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 230 1 1 4 2.0 Nc1c(N2CCCC2)c2ccccc2oc1=O nan
CHEMBL1594894 52785 26 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 230 1 1 4 2.0 Nc1c(N2CCCC2)c2ccccc2oc1=O nan
788616 53074 8 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 269 5 1 4 2.8 COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 nan
CHEMBL1597563 53074 8 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 269 5 1 4 2.8 COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 nan
2998385 25154 1 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 381 8 1 6 2.7 CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
CHEMBL1347643 25154 1 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 381 8 1 6 2.7 CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 nan
9549748 23239 8 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 1 1 4.4 SC1=NCCc2ccccc2C1c1ccccc1Cl nan
CHEMBL1331656 23239 8 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 287 1 1 1 4.4 SC1=NCCc2ccccc2C1c1ccccc1Cl nan
2939261 22115 6 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 3 4 3.4 CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
CHEMBL1322052 22115 6 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 329 4 3 4 3.4 CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 nan
14956799 106899 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314590 106899 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 509 10 2 8 4.0 CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956766 106979 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315128 106979 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for AT1 receptor by displacing 125I[Sar, ILe8]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 471 7 1 7 4.5 CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956813 206339 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 477 9 1 7 4.1 O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87330 206339 0 None - 1 Rabbit 7.9 pIC50 = 7.9 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 477 9 1 7 4.1 O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44211606 101213 0 None - 1 Bovine 6.9 pIC50 = 6.9 Functional
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 10 1 10 5.2 CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
CHEMBL295905 101213 0 None - 1 Bovine 6.9 pIC50 = 6.9 Functional
In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.
ChEMBL 591 10 1 10 5.2 CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1016/S0960-894X(00)80365-0
44246747 55837 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
CHEMBL1521291 55837 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
CHEMBL1623128 55837 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 429 3 2 5 3.2 O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 nan
135501733 37060 17 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 336 3 2 5 2.4 Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 nan
CHEMBL1452116 37060 17 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 336 3 2 5 2.4 Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 nan
2898747 36766 12 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 0 7 1.8 O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1449757 36766 12 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 418 6 0 7 1.8 O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
788619 45567 10 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 nan
CHEMBL1528883 45567 10 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 273 4 1 2 4.3 Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 nan
3648468 51507 8 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 4 1 3 4.6 O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 nan
CHEMBL1582697 51507 8 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 4 1 3 4.6 O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 nan
135419079 30226 7 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 2 2 5 4.0 Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O nan
CHEMBL1390716 30226 7 None -1 4 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 340 2 2 5 4.0 Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O nan
877472 36676 8 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 323 4 1 2 4.4 O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 nan
CHEMBL1449035 36676 8 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 323 4 1 2 4.4 O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 nan
902793 43213 18 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 nan
CHEMBL1505893 43213 18 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 309 4 0 4 3.4 O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 nan
67903280 186202 0 None 4 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4872989 186202 0 None 4 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
44355662 26462 0 None 125 2 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
CHEMBL135999 26462 0 None 125 2 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 506 6 1 5 6.7 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 10.1021/jm00078a013
10004013 116693 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 7 1 7 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 10.1021/jm00078a014
CHEMBL337217 116693 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 452 7 1 7 4.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 10.1021/jm00078a014
14956744 206163 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86255 206163 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 481 9 1 8 4.3 CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
1726745 23930 11 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 3.4 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl nan
CHEMBL1337184 23930 11 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 390 8 1 6 3.4 O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl nan
5731702 186652 10 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 3 1 3 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 nan
CHEMBL488140 186652 10 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 277 3 1 3 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 nan
2476054 47897 3 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 3 3 4 3.9 FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 nan
CHEMBL1549272 47897 3 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 347 3 3 4 3.9 FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 nan
2458676 31410 4 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 6 1 6 2.4 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 nan
CHEMBL1402558 31410 4 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 373 6 1 6 2.4 CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 nan
2221657 34515 11 None -3 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 2 0 5 3.6 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 nan
CHEMBL1428950 34515 11 None -3 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 353 2 0 5 3.6 O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 nan
44342039 10293 0 None -21 3 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL116170 10293 0 None -21 3 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assayAntagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
2426360 46887 6 None -8 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 3 3 3 4.6 Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 nan
CHEMBL1540808 46887 6 None -8 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 382 3 3 3 4.6 Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 nan
9653239 107648 5 None - 1 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 3 2 4 2.7 O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O nan
CHEMBL3190198 107648 5 None - 1 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 291 3 2 4 2.7 O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O nan
5730138 34794 11 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 307 4 1 4 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
CHEMBL1431014 34794 11 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 307 4 1 4 4.1 COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
12005285 53064 6 None 3 2 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
CHEMBL1597454 53064 6 None 3 2 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 8 1 9 4.0 CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] nan
1767917 31236 10 None -3 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 375 5 3 4 2.2 Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br nan
CHEMBL1401122 31236 10 None -3 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 375 5 3 4 2.2 Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br nan
14956806 106930 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 497 10 1 8 5.0 CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314810 106930 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 497 10 1 8 5.0 CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956768 106971 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 8 1 7 5.2 CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL315077 106971 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 499 8 1 7 5.2 CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956745 206269 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL86906 206269 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 465 8 1 7 4.6 CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14951062 206391 0 None -1 2 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL87669 206391 0 None -1 2 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 429 9 1 7 3.7 CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14971694 14692 0 None - 1 Rabbit 6.8 pIC50 = 6.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
CHEMBL120605 14692 0 None - 1 Rabbit 6.8 pIC50 = 6.8 Functional
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
ChEMBL 416 8 2 6 4.0 CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00075a014
44355660 21557 0 None 89 2 Rabbit 6.8 pIC50 = 6.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
CHEMBL131676 21557 0 None 89 2 Rabbit 6.8 pIC50 = 6.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 483 7 1 7 5.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 10.1021/jm00078a013
10410730 24618 0 None 6 2 Rabbit 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
CHEMBL134307 24618 0 None 6 2 Rabbit 5.8 pIC50 = 5.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 435 5 0 5 5.6 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 10.1021/jm00078a013
2898434 53868 12 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 6 0 7 1.9 O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1604741 53868 12 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 406 6 0 7 1.9 O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 nan
3532334 42352 9 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 2 1 4 3.2 O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 nan
CHEMBL1498428 42352 9 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 303 2 1 4 3.2 O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 nan
2640418 22148 7 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 6 0 6 2.5 O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1322344 22148 7 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 377 6 0 6 2.5 O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
5687785 108404 2 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 346 5 1 5 3.2 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
CHEMBL3198576 108404 2 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 346 5 1 5 3.2 O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 nan
5735740 41650 10 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 1 4 4.5 CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
CHEMBL1491932 41650 10 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 321 5 1 4 4.5 CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC nan
2320855 36552 6 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 nan
CHEMBL1448161 36552 6 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 333 4 4 7 0.6 O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 nan
5091521 25295 7 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 2 2 9 2.9 CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 nan
CHEMBL1348954 25295 7 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 402 2 2 9 2.9 CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 nan
2121806 42065 5 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 266 4 1 6 2.3 CCSc1nnc(NC(=O)c2ccccn2)s1 nan
CHEMBL1495849 42065 5 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 266 4 1 6 2.3 CCSc1nnc(NC(=O)c2ccccn2)s1 nan
2733001 29297 4 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 1 4 3.7 Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 nan
CHEMBL1382939 29297 4 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 288 5 1 4 3.7 Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 nan
25162518 39852 5 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 417 8 0 6 2.7 O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
CHEMBL1477291 39852 5 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 417 8 0 6 2.7 O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 nan
14956784 106557 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL314179 106557 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 447 9 1 9 2.5 CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
14956764 206077 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
CHEMBL85541 206077 0 None - 1 Rabbit 7.8 pIC50 = 7.8 Functional
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
ChEMBL 541 8 1 7 5.0 CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1021/jm00069a015
44355628 24906 0 None 5 2 Rabbit 6.8 pIC50 = 6.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
CHEMBL134567 24906 0 None 5 2 Rabbit 6.8 pIC50 = 6.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 508 6 1 5 6.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O 10.1021/jm00078a013
10095493 26048 0 None 93 2 Rabbit 6.8 pIC50 = 6.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
CHEMBL135521 26048 0 None 93 2 Rabbit 6.8 pIC50 = 6.8 Functional
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
ChEMBL 454 6 0 6 4.9 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 10.1021/jm00078a013
1336623 38287 20 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 350 5 0 6 3.5 Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 nan
CHEMBL1462517 38287 20 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 350 5 0 6 3.5 Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 nan
2165745 34680 9 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 8 1 8 0.7 O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
CHEMBL1430172 34680 9 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 425 8 1 8 0.7 O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 nan
659805 21966 6 None -2 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 302 1 2 4 3.7 ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 nan
CHEMBL1320678 21966 6 None -2 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 302 1 2 4 3.7 ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 nan
135415440 199050 11 None -10 5 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
CHEMBL586135 199050 11 None -10 5 Human 5.8 pIC50 = 5.8 Functional
PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]PUBCHEM_BIOASSAY: Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays: 2569, 2521 ]
ChEMBL 295 3 2 6 3.0 Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 nan
579121 49132 12 None -1 2 Human 4.8 pIC50 =