Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL408403 agtr1_human Human Yes 9.3 EC50 = 0.5 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
None None None None
CHEMBL408403 agtr1_human Human Yes 9.3 EC50 = 0.5 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
None None None None
CHEMBL3787243 agtr1_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787375 agtr1_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787700 agtr1_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787243 agtr1_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787375 agtr1_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787700 agtr1_human Human No 9.0 EC50 = 1.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1216 35 15 14 -0.7 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL408403 agtra_rat Rat Yes 8.9 EC50 = 1.3 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None None
CHEMBL3786145 agtr1_human Human No 8.9 EC50 = 1.4 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787767 agtr1_human Human No 8.9 EC50 = 1.4 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3786145 agtr1_human Human No 8.9 EC50 = 1.4 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787767 agtr1_human Human No 8.9 EC50 = 1.4 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1160 33 15 14 -1.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL4483576 agtr1_human Human No 8.0 EC50 = 10 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4514079 agtra_rat Rat No 8.0 EC50 = 10 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4518318 agtr1_human Human No 7.0 EC50 = 100 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4535678 agtr1_human Human No 7.0 EC50 = 100 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4572408 agtra_rat Rat No 7.0 EC50 = 100 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4577692 agtra_rat Rat No 7.0 EC50 = 100 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4532075 agtr1_human Human No 6.0 EC50 = 1000 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4592000 agtr1_human Human No 6.0 EC50 = 1000 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4556070 agtr1_human Human No 5.0 EC50 = 10000 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4524570 agtra_rat Rat No 5.0 EC50 = 10000 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4556070 agtra_rat Rat No 5.0 EC50 = 10000 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
980 26 12 12 -0.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL938 agtr1_human Human Yes 8.0 EC50 = 11 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL4438122 agtra_rat Rat No 8.0 EC50 = 11 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None None
CHEMBL4559239 agtr1_human Human No 7.0 EC50 = 110 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C
CHEMBL4529051 agtra_rat Rat No 7.0 EC50 = 110 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O
CHEMBL4518530 agtr1_human Human No 7.9 EC50 = 12 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL4518530 agtra_rat Rat No 7.9 EC50 = 12 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL4515768 agtra_rat Rat No 6.9 EC50 = 120 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4517561 agtra_rat Rat No 6.9 EC50 = 120 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O
CHEMBL4482867 agtr1_human Human No 5.9 EC50 = 1200 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4561769 agtr1_human Human No 5.9 EC50 = 1200 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4572408 agtr1_human Human No 5.9 EC50 = 1200 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL27511 agtr1_bovin Bovine No 5.9 EC50 = 1250 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
486 5 2 7 5.0 Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1
CHEMBL281887 agtr1_bovin Bovine No 5.9 EC50 = 1250 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
461 5 2 6 4.6 O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2
CHEMBL4514079 agtr1_human Human No 7.9 EC50 = 13 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
944 26 13 12 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4518318 agtra_rat Rat No 7.9 EC50 = 13 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4533618 agtra_rat Rat No 7.9 EC50 = 13 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4549405 agtra_rat Rat No 7.9 EC50 = 13 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4522246 agtra_rat Rat No 6.9 EC50 = 130 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4524300 agtr1_human Human No 5.9 EC50 = 1300 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL2028943 agtra_rat Rat No 7.9 EC50 = 14 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL2370909 agtra_rat Rat No 6.9 EC50 = 140 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4522038 agtr1_human Human No 5.9 EC50 = 1400 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
CHEMBL4574199 agtr1_human Human No 5.9 EC50 = 1400 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4516768 agtra_rat Rat No 5.9 EC50 = 1400 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL2392353 agtra_rat Rat Yes 7.8 EC50 = 15 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL4297447 agtra_rat Rat Yes 7.8 EC50 = 16 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL4591857 agtra_rat Rat No 7.8 EC50 = 16 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL2028943 agtr1_human Human No 6.8 EC50 = 160 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4518420 agtr1_human Human No 6.8 EC50 = 160 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4573250 agtr1_human Human No 6.8 EC50 = 160 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O
CHEMBL4557984 agtra_rat Rat No 6.8 EC50 = 160 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4588454 agtra_rat Rat Yes 6.8 EC50 = 160 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL4527484 agtr1_human Human No 5.8 EC50 = 1600 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4544308 agtr1_human Human No 5.8 EC50 = 1600 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL4570840 agtr1_human Human No 5.8 EC50 = 1600 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4571382 agtr1_human Human No 5.8 EC50 = 1600 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1
CHEMBL4576650 agtr1_human Human No 5.8 EC50 = 1600 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4576650 agtra_rat Rat No 4.8 EC50 = 16000 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4542269 agtr1_human Human No 7.8 EC50 = 17 nM Bind
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
877 29 13 12 -2.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4297447 agtr1_human Human Yes 7.8 EC50 = 17 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL4577691 agtra_rat Rat No 7.8 EC50 = 17 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C
CHEMBL4551317 agtr1_human Human No 5.8 EC50 = 1700 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL25226 agtr1_bovin Bovine No 5.8 EC50 = 1700 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
471 5 2 6 5.3 O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL4564950 agtra_rat Rat No 7.8 EC50 = 18 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4573250 agtra_rat Rat No 6.8 EC50 = 180 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O
CHEMBL4579604 agtra_rat Rat No 6.8 EC50 = 180 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4554466 agtr1_human Human No 5.8 EC50 = 1800 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL24842 agtr1_bovin Bovine No 5.8 EC50 = 1800 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
491 7 2 5 6.2 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1
CHEMBL4567667 agtra_rat Rat No 7.7 EC50 = 19 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C
CHEMBL4515768 agtr1_human Human No 6.7 EC50 = 190 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4544308 agtra_rat Rat No 5.7 EC50 = 1900 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL4551317 agtra_rat Rat No 5.7 EC50 = 1900 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4572408 agtra_rat Rat No 5.7 EC50 = 1900 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
2296 33 30 27 -2.1 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL3786986 agtr1_human Human No 8.7 EC50 = 2.0 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787768 agtr1_human Human No 8.7 EC50 = 2.0 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3786986 agtr1_human Human No 8.7 EC50 = 2.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787768 agtr1_human Human No 8.7 EC50 = 2.1 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1220 37 15 16 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O
CHEMBL3787379 agtr1_human Human No 8.6 EC50 = 2.3 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787701 agtr1_human Human No 8.6 EC50 = 2.3 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787379 agtr1_human Human No 8.6 EC50 = 2.4 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL3787701 agtr1_human Human No 8.6 EC50 = 2.4 nM Funct
Agonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assayAgonist activity at human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ assessed as induction of intracellular Ca2+ mobilization by bioluminescence assay
1276 39 15 16 -1.4 CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C
CHEMBL408403 agtr1_human Human Yes 8.6 EC50 = 2.6 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None None
CHEMBL4518530 agtr1_human Human No 8.6 EC50 = 2.7 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL4567667 agtr1_human Human No 7.7 EC50 = 20 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C
CHEMBL4588454 agtra_rat Rat Yes 7.7 EC50 = 20 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL4542709 agtr1_human Human No 6.7 EC50 = 200 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4554466 agtra_rat Rat No 6.7 EC50 = 200 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4545399 agtra_rat Rat No 6.7 EC50 = 200 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4555119 agtra_rat Rat No 6.7 EC50 = 200 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C
CHEMBL4590381 agtr1_human Human No 5.7 EC50 = 2000 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL2392353 agtr1_human Human Yes 7.7 EC50 = 21 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL4555119 agtr1_human Human No 6.7 EC50 = 210 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C
CHEMBL4544228 agtr1_human Human No 5.7 EC50 = 2100 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL4482867 agtra_rat Rat No 5.7 EC50 = 2100 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 14 13 -2.3 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4546162 agtra_rat Rat No 5.7 EC50 = 2100 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4588946 agtr1_human Human Yes 6.7 EC50 = 220 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL4573250 agtra_rat Rat No 6.7 EC50 = 220 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
925 26 13 12 -2.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O
CHEMBL28162 agtr1_bovin Bovine No 5.7 EC50 = 2200 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
501 6 2 7 5.3 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1
CHEMBL4516066 agtra_rat Rat No 6.6 EC50 = 230 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4562270 agtra_rat Rat No 7.6 EC50 = 24 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4551317 agtra_rat Rat No 6.6 EC50 = 240 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
2269 27 21 24 3.8 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4533618 agtr1_human Human No 7.6 EC50 = 25 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4591448 agtr1_human Human No 7.6 EC50 = 25 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4564617 agtra_rat Rat No 7.6 EC50 = 25 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4516066 agtr1_human Human No 6.6 EC50 = 250 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4577692 agtr1_human Human No 6.6 EC50 = 250 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1081 26 13 12 -0.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4547423 agtra_rat Rat No 6.6 EC50 = 250 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4559421 agtra_rat Rat No 5.6 EC50 = 2500 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4561366 agtra_rat Rat No 5.6 EC50 = 2500 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4533618 agtra_rat Rat No 4.6 EC50 = 25000 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
959 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4583284 agtra_rat Rat No 4.6 EC50 = 25000 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4560224 agtra_rat Rat No 7.6 EC50 = 26 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4544228 agtra_rat Rat No 6.6 EC50 = 260 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None None
CHEMBL4516768 agtra_rat Rat No 6.6 EC50 = 260 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4547423 agtra_rat Rat No 7.6 EC50 = 27 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4560224 agtra_rat Rat No 7.6 EC50 = 27 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4547423 agtr1_human Human No 6.6 EC50 = 270 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
949 26 14 13 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4567103 agtra_rat Rat No 6.6 EC50 = 270 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4590589 agtra_rat Rat No 6.6 EC50 = 270 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4554466 agtra_rat Rat No 5.6 EC50 = 2700 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
910 26 12 11 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL274447 agtr1_bovin Bovine Yes 5.6 EC50 = 2700 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
398 8 2 4 4.8 CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL4590381 agtra_rat Rat No 5.6 EC50 = 2800 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
945 26 13 12 -2.0 CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL77838 agtr1_human Human Yes 8.5 EC50 = 3.4 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O
CHEMBL77838 agtra_rat Rat Yes 8.5 EC50 = 3.5 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O
CHEMBL4543860 agtr1_human Human No 8.4 EC50 = 3.6 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4560224 agtr1_human Human No 7.5 EC50 = 30 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
897 26 15 12 -3.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4522038 agtra_rat Rat No 6.5 EC50 = 300 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
CHEMBL4564950 agtr1_human Human No 7.5 EC50 = 31 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
975 26 14 13 -2.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4536886 agtra_rat Rat No 7.5 EC50 = 31 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C
CHEMBL4593310 agtra_rat Rat No 7.5 EC50 = 31 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4591857 agtr1_human Human No 7.5 EC50 = 32 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL2028943 agtra_rat Rat No 7.5 EC50 = 32 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4591448 agtra_rat Rat No 7.5 EC50 = 32 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4522246 agtr1_human Human No 6.5 EC50 = 320 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4549405 agtr1_human Human No 7.5 EC50 = 33 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
959 26 13 12 -1.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4516768 agtr1_human Human No 6.5 EC50 = 330 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4529051 agtr1_human Human No 6.5 EC50 = 330 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
853 24 12 11 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O
CHEMBL4543860 agtra_rat Rat No 6.5 EC50 = 330 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4579604 agtr1_human Human No 6.5 EC50 = 340 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4555119 agtra_rat Rat No 7.5 EC50 = 35 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
911 25 13 12 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C
CHEMBL191 agtr1_bovin Bovine Yes 6.5 EC50 = 350 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl
CHEMBL4581718 agtra_rat Rat No 6.4 EC50 = 360 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O
CHEMBL4574655 agtra_rat Rat No 5.4 EC50 = 3600 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
941 27 14 13 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4518318 agtra_rat Rat No 7.4 EC50 = 37 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
926 25 12 12 -2.0 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4577270 agtra_rat Rat No 7.4 EC50 = 38 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4515848 agtr1_human Human No 7.4 EC50 = 39 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4438122 agtra_rat Rat No 7.4 EC50 = 39 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL4515768 agtr1_human Human No 6.4 EC50 = 390 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4524300 agtra_rat Rat No 5.4 EC50 = 3900 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
975 27 14 13 -1.9 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL312754 agtra_rat Rat Yes 8.3 EC50 = 4.8 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4536886 agtr1_human Human No 7.4 EC50 = 40 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
926 25 13 12 -1.9 CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C
CHEMBL4535997 agtra_rat Rat No 7.4 EC50 = 40 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4557984 agtr1_human Human No 6.4 EC50 = 400 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 13 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4583284 agtra_rat Rat No 6.4 EC50 = 400 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4559421 agtra_rat Rat No 5.4 EC50 = 4000 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4517561 agtra_rat Rat No 7.4 EC50 = 41 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O
CHEMBL4577691 agtr1_human Human No 7.4 EC50 = 42 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
840 23 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C
CHEMBL4588946 agtra_rat Rat Yes 7.4 EC50 = 42 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL4570840 agtra_rat Rat No 6.4 EC50 = 420 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
811 22 12 11 -3.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4562270 agtra_rat Rat No 7.4 EC50 = 43 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4543860 agtr1_human Human No 6.4 EC50 = 430 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4564094 agtra_rat Rat No 4.4 EC50 = 43000 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4438122 agtr1_human Human No 7.4 EC50 = 44 nM Bind
Agonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assayAgonist activity at human AT1 receptor assessed as increase in beta-arrestin recruitment by chemiluminescent assay
None None None None
CHEMBL4438122 agtr1_human Human No 7.4 EC50 = 44 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL4522038 agtra_rat Rat No 6.4 EC50 = 440 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
904 24 13 12 -1.5 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C
CHEMBL4517561 agtr1_human Human No 6.4 EC50 = 450 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
904 27 12 11 -1.2 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O
CHEMBL4543860 agtra_rat Rat No 6.4 EC50 = 450 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
947 25 14 13 -2.5 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4581718 agtr1_human Human No 5.4 EC50 = 4500 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
917 28 12 11 -1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O
CHEMBL4564094 agtr1_human Human No 5.3 EC50 = 4600 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
782 21 11 10 -1.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4545153 agtr1_human Human No 6.3 EC50 = 480 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4546162 agtr1_human Human No 5.3 EC50 = 4800 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4483576 agtra_rat Rat No 8.3 EC50 = 5 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
945 26 13 13 -2.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4535997 agtr1_human Human No 7.3 EC50 = 50 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
943 26 14 14 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4542709 agtra_rat Rat No 7.3 EC50 = 50 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
911 26 13 12 -2.2 CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4532075 agtra_rat Rat No 6.3 EC50 = 500 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
966 26 12 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4576650 agtra_rat Rat No 6.3 EC50 = 500 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1177 26 13 12 -0.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL282566 agtr1_bovin Bovine No 6.3 EC50 = 500 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
515 7 2 7 5.7 CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1
CHEMBL4559421 agtr1_human Human No 5.3 EC50 = 5000 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1015 28 13 16 -2.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL3355127 agtr1_human Human No 5.3 EC50 = 5100 nM Bind
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
422 2 1 5 3.6 C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12
CHEMBL4551431 agtr1_human Human No 6.3 EC50 = 530 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4551431 agtra_rat Rat No 6.3 EC50 = 530 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
931 25 13 12 -2.2 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4588454 agtr1_human Human Yes 6.3 EC50 = 550 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL3355137 agtr1_human Human No 5.3 EC50 = 5500 nM Bind
Agonist activity at AT1 receptor (unknown origin)Agonist activity at AT1 receptor (unknown origin)
436 2 1 5 3.9 Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1
CHEMBL1460676 agtr1_human Human Yes 4.2 EC50 = 57800 nM Funct
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1
CHEMBL1621632 agtr1_human Human Yes 4.2 EC50 = 57800 nM Funct
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
548 8 0 6 5.0 Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1
CHEMBL4559239 agtra_rat Rat No 7.2 EC50 = 59 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C
CHEMBL4545399 agtr1_human Human No 6.2 EC50 = 590 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 27 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL938 agtra_rat Rat Yes 8.2 EC50 = 6 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL77838 agtra_rat Rat Yes 8.2 EC50 = 6.1 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O
CHEMBL312754 agtra_rat Rat Yes 8.2 EC50 = 6.6 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4588946 agtra_rat Rat Yes 8.2 EC50 = 6.8 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL408403 agtra_rat Rat Yes 8.2 EC50 = 6.8 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL282082 agtr1_bovin Bovine No 6.2 EC50 = 600 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
517 6 2 7 6.0 CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1
CHEMBL26875 agtr1_bovin Bovine No 5.2 EC50 = 6000 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
477 5 2 7 5.3 O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL4564617 agtr1_human Human No 7.2 EC50 = 63 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
970 27 13 14 -2.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4515848 agtra_rat Rat No 7.2 EC50 = 63 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4535678 agtra_rat Rat No 7.2 EC50 = 63 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
942 26 14 13 -2.2 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4545153 agtra_rat Rat No 7.2 EC50 = 63 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL4583284 agtr1_human Human No 6.2 EC50 = 630 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
954 26 13 12 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4590589 agtr1_human Human No 6.2 EC50 = 630 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
877 24 13 12 -3.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4571382 agtra_rat Rat No 6.2 EC50 = 630 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
966 29 12 12 -1.1 C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1
CHEMBL4592000 agtra_rat Rat No 6.2 EC50 = 630 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
898 26 11 12 -1.0 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4567667 agtra_rat Rat No 7.2 EC50 = 64 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
1052 28 14 13 -0.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C
CHEMBL4544308 agtr1_human Human No 7.2 EC50 = 65 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL4588454 agtr1_human Human Yes 6.2 EC50 = 660 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
955 27 14 13 -2.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
CHEMBL4527484 agtra_rat Rat No 6.2 EC50 = 660 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
887 24 12 11 -1.8 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4524570 agtr1_human Human No 5.2 EC50 = 6700 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
959 27 13 12 -1.6 CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4561366 agtr1_human Human No 6.2 EC50 = 680 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4567103 agtr1_human Human No 6.2 EC50 = 680 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
917 28 13 12 -1.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL2392353 agtra_rat Rat Yes 8.1 EC50 = 7.3 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None None
CHEMBL4545153 agtra_rat Rat No 8.1 EC50 = 7.4 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
969 28 16 13 -3.7 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C
CHEMBL938 agtra_rat Rat Yes 8.1 EC50 = 7.5 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL4544902 agtr1_human Human No 8.1 EC50 = 7.9 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4544902 agtra_rat Rat No 8.1 EC50 = 7.9 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 13 13 -2.3 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL1704271 agtr1_human Human Yes 5.1 EC50 = 7440 nM Funct
PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]PUBCHEM_BIOASSAY: Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2520, AID2580]
436 4 0 5 5.8 CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O
CHEMBL4577270 agtr1_human Human No 7.1 EC50 = 75 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
903 24 13 12 -2.1 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL4516066 agtra_rat Rat No 7.1 EC50 = 77 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4562270 agtr1_human Human No 7.1 EC50 = 79 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
940 26 12 12 -1.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4515768 agtra_rat Rat No 7.1 EC50 = 79 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
953 27 13 12 -1.9 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O
CHEMBL4518420 agtra_rat Rat No 7.1 EC50 = 79 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
928 26 12 11 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL2028943 agtr1_human Human No 8.1 EC50 = 8 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4515848 agtra_rat Rat No 8.1 EC50 = 8.2 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
940 26 13 12 -1.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O
CHEMBL4546799 agtra_rat Rat No 8.1 EC50 = 8.2 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL4516066 agtr1_human Human No 6.1 EC50 = 820 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
1017 28 14 13 -1.6 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O
CHEMBL4574199 agtra_rat Rat No 6.1 EC50 = 820 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
961 26 14 13 -2.1 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL4561769 agtra_rat Rat No 6.1 EC50 = 870 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
945 26 13 12 -1.8 CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O
CHEMBL2370909 agtr1_human Human No 6.1 EC50 = 880 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4546799 agtr1_human Human No 8.0 EC50 = 9.2 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
927 26 13 13 -2.9 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C
CHEMBL312754 agtr1_human Human Yes 8.0 EC50 = 9.2 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O
CHEMBL4518530 agtra_rat Rat No 8.0 EC50 = 9.3 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
954 28 13 12 -1.1 CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O
CHEMBL408403 agtr1_human Human Yes 8.0 EC50 = 9.7 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL284877 agtr1_bovin Bovine No 7.1 EC50 = 90 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
505 6 2 7 5.9 CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1
CHEMBL4544228 agtra_rat Rat No 6.0 EC50 = 910 nM Bind
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
None None None None
CHEMBL2370909 agtra_rat Rat No 7.0 EC50 = 92 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O
CHEMBL4559239 agtr1_human Human No 6.0 EC50 = 920 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
790 23 12 11 -4.6 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C
CHEMBL4561366 agtra_rat Rat No 6.0 EC50 = 920 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
756 9 7 8 1.3 CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O
CHEMBL4593310 agtr1_human Human No 7.0 EC50 = 95 nM Bind
Agonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 60 mins by luminescence based beta-arrestin recruitment assay
869 25 13 12 -3.2 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
CHEMBL28160 agtr1_bovin Bovine No 5.0 EC50 = 9500 nM Bind
Inhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortexInhibition of [125I]AII binding to angiotensin II receptor of bovine adrenal cortex
477 6 2 5 5.8 COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1
CHEMBL4588946 agtr1_human Human Yes 7.0 EC50 = 96 nM Funct
Agonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at human AT1R expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
742 22 12 10 -2.4 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C
CHEMBL4544308 agtra_rat Rat No 7.0 EC50 = 96 nM Funct
Agonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assayAgonist activity at rat AT1aR expressed in HEK293 cells incubated for 30 mins by IP1 accumulation assay
791 23 12 11 -4.0 CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C
CHEMBL138690 agtr1_rabit Rabbit No 10.4 IC50 = 0.0 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL138690 agtr1_rabit Rabbit No 10.4 IC50 = 0.0 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
729 12 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL346728 agtr1_human Human No 10.3 IC50 = 0.1 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
614 9 1 6 7.0 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1
CHEMBL265797 agtr1_rabit Rabbit No 10.3 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL265797 agtr1_rabit Rabbit No 10.3 IC50 = 0.1 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL265797 agtr1_rabit Rabbit No 10.3 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
691 11 2 8 6.5 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL48242 agtr1_rabit Rabbit Yes 10.3 IC50 = 0.1 nM Funct
Antagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aortic strip assessed as inhibition of angiotensin 2-induced contractile response
452 8 2 6 5.0 CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL341828 agtr1_rabit Rabbit No 10.1 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1
CHEMBL339672 agtr1_rabit Rabbit No 10.1 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL339672 agtr1_rabit Rabbit No 10.1 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL341828 agtr1_rabit Rabbit No 10.1 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
695 13 2 9 7.1 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1
CHEMBL339672 agtr1_rabit Rabbit No 10.1 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL343309 agtr1_rabit Rabbit No 10.1 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL343309 agtr1_rabit Rabbit No 10.1 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
717 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL339722 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL24322 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Binding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSABinding affinity against AT-1 receptor from rabbit aorta using [125I]-Sar1-Ile8-Ang II without BSA
550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL305017 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
782 17 1 9 8.2 CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL305238 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
706 16 2 9 6.9 CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL307318 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
706 17 2 9 7.0 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1
CHEMBL69721 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
693 17 1 9 7.3 CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70161 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
705 17 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70370 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
707 18 1 9 7.5 CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70789 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
679 15 1 9 7.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70843 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
746 16 1 10 6.6 CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70935 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
677 15 1 9 6.8 CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL24322 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Displacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membraneDisplacement of [125 I]Sar1Ile8-AII from type 1 Angiotensin II receptor of rabbit aorta membrane
550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2435828 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
531 10 2 4 7.3 CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL24322 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL304947 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
657 15 2 7 7.7 CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C
CHEMBL68638 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
544 9 1 6 6.1 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1
CHEMBL339722 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL24322 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL24322 agtr1_human Human No 10.0 IC50 = 0.1 nM Bind
Inhibitory concentration against angiotensin II receptor, type 1Inhibitory concentration against angiotensin II receptor, type 1
550 9 2 7 5.5 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL316300 agtr1_rabit Rabbit Yes 10.0 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL341934 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL343142 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL316300 agtr1_rabit Rabbit Yes 10.0 IC50 = 0.1 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL306407 agtr1_rabit Rabbit Yes 10.0 IC50 = 0.1 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
633 15 2 8 7.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1
CHEMBL316300 agtr1_rabit Rabbit Yes 10.0 IC50 = 0.1 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL316300 agtr1_rabit Rabbit Yes 10.0 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
668 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL341934 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
719 13 2 8 7.3 CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL343142 agtr1_rabit Rabbit No 10.0 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
733 13 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL140708 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL124771 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL68618 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
643 15 2 7 7.4 CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1
CHEMBL124771 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL140708 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
767 13 2 8 7.7 CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL353037 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
633 12 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL124771 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL332576 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F
CHEMBL339256 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL339605 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL332576 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
691 12 2 9 6.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F
CHEMBL339256 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL339605 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL330533 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1
CHEMBL306362 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
691 13 2 8 6.7 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F
CHEMBL139452 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338101 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL332909 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL338101 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL435811 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL332909 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL338101 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL435811 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL435811 agtr1_human Human No 9.9 IC50 = 0.1 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL139452 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
734 13 3 8 7.0 CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338101 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL332909 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL338101 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
733 14 2 8 7.0 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL435811 agtr1_rabit Rabbit No 9.9 IC50 = 0.1 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL329679 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
686 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL94905 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
640 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1
CHEMBL352771 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
651 11 3 7 6.1 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL353800 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
647 13 3 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL136465 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL96075 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL338027 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339004 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL96075 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL338027 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339004 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL316706 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
636 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1
CHEMBL136465 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
733 11 2 8 7.5 CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL96075 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
733 14 2 8 7.6 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1
CHEMBL317343 agtrb_rat Rat No 9.8 IC50 = 0.2 nM Bind
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50
492 10 2 5 6.1 CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c(Cl)c1Cl
CHEMBL338027 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339004 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL93907 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340632 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL93907 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL72838 agtr1_human Human No 9.8 IC50 = 0.2 nM Bind
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
425 4 2 8 3.0 Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1
CHEMBL93907 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340632 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL93907 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL97075 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
706 10 1 8 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1
CHEMBL98068 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
748 12 1 9 8.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC
CHEMBL93907 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL354779 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
661 14 3 8 6.6 CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL93907 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
705 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340632 agtr1_rabit Rabbit No 9.8 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL337118 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL329616 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
546 9 2 6 6.7 CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL337118 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
719 12 2 8 7.1 CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL169221 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
619 12 3 8 5.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
CHEMBL169568 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1
CHEMBL125008 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL2236976 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
771 13 2 8 8.0 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL125008 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL331450 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
723 12 2 8 6.1 CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1
CHEMBL1184032 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL329290 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
692 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1
CHEMBL311160 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
687 10 3 7 6.2 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1
CHEMBL415073 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
679 13 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1
CHEMBL352503 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
632 14 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1
CHEMBL125008 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
777 11 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL2236976 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
771 13 2 8 8.0 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL122917 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F
CHEMBL331507 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL293511 agtr1_human Human Yes 9.7 IC50 = 0.2 nM Funct
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL288246 agtr1_rabit Rabbit Yes 9.7 IC50 = 0.2 nM Funct
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
510 9 1 8 3.5 CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
CHEMBL302964 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
707 18 1 9 7.7 CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL303427 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
792 19 1 10 8.6 CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL308323 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
741 17 1 10 6.7 CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL311253 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
732 15 1 10 6.2 CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL311625 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
725 17 1 9 7.1 CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL430792 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
720 17 2 9 7.3 CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL70868 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
790 21 1 9 8.5 CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL71172 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
739 16 1 9 8.1 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
CHEMBL71639 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
709 17 1 9 8.1 CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL73283 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
773 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL293511 agtr1_rabit Rabbit Yes 9.7 IC50 = 0.2 nM Bind
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL105199 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
534 9 1 7 5.8 CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1
CHEMBL293511 agtr1_rabit Rabbit Yes 9.7 IC50 = 0.2 nM Bind
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL318605 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1Compound was evaluated for inhibition of 125I[Sar1,Ile8] all binding to rabbit aorta Angiotensin II receptor, type 1
520 9 1 7 5.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1
CHEMBL433646 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
492 10 2 6 5.4 CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL293511 agtr1_rabit Rabbit Yes 9.7 IC50 = 0.2 nM Bind
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL122917 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F
CHEMBL331507 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL350121 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
554 16 3 6 5.8 CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1
CHEMBL97332 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
670 11 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1
CHEMBL305647 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
701 11 3 7 6.6 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F
CHEMBL338027 agtr1_human Human No 9.7 IC50 = 0.2 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
729 11 2 9 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL293511 agtr1_rabit Rabbit Yes 9.7 IC50 = 0.2 nM Bind
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL122917 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
717 12 2 8 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F
CHEMBL331507 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
735 12 2 10 6.0 CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL275552 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL334300 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL435792 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL334300 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL341369 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL335778 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
490 7 1 6 4.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1
CHEMBL334300 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL341369 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL328941 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1
CHEMBL275552 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
739 12 2 8 7.2 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL334300 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL435792 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
747 12 2 8 7.9 CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL169967 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
647 12 2 8 6.2 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL334300 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL341369 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122273 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL125280 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL122273 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL125280 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL329693 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
652 10 1 8 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1
CHEMBL94145 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
676 10 1 9 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1
CHEMBL122273 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL125280 agtr1_rabit Rabbit No 9.7 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL122380 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1
CHEMBL122380 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1
CHEMBL74556 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
693 13 2 8 6.9 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL122380 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
769 12 2 8 6.7 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1
CHEMBL331455 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL338342 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL120199 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
506 11 2 6 5.6 CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL92654 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
546 9 2 6 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL331455 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL338342 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL259843 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL74476 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL74476 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL169488 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
633 13 3 8 5.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1
CHEMBL74476 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
661 13 2 8 6.5 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1
CHEMBL331455 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL338342 agtr1_rabit Rabbit No 9.6 IC50 = 0.2 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
763 10 2 9 7.1 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL341783 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344597 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL125231 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl
CHEMBL319730 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
733 13 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL339256 agtr1_human Human No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL125231 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
745 11 2 9 7.1 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl
CHEMBL341783 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
692 11 1 9 6.3 CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344597 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
781 14 2 8 8.1 CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL168413 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
619 11 3 8 5.4 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1
CHEMBL169968 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
675 11 2 9 5.4 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL353615 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
647 14 3 8 6.2 CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1
CHEMBL139041 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338433 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL444065 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL304946 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
643 13 2 7 7.2 CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C
CHEMBL338433 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
749 13 2 10 6.4 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL444065 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL95579 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
624 10 1 8 5.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1
CHEMBL139041 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
735 13 2 9 7.5 CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL168490 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
605 11 3 8 5.0 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1
CHEMBL339040 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL71388 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
619 14 2 8 6.8 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1
CHEMBL131156 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
490 8 1 6 4.9 CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1
CHEMBL339040 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL407919 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
702 10 1 7 7.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1
CHEMBL97446 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
674 10 1 8 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1
CHEMBL339040 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL121872 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339113 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL70726 agtr1_human Human No 9.6 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
CHEMBL121872 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339113 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL334300 agtr1_human Human No 9.6 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
667 11 2 9 6.3 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL121872 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
743 12 2 9 6.3 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL339113 agtr1_rabit Rabbit No 9.6 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL276674 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL276674 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
701 11 2 9 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL343634 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
739 13 2 8 8.1 CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL7550 agtr1_human Human Yes 9.5 IC50 = 0.3 nM Funct
Antagonist activity at angiotensin 1 receptorAntagonist activity at angiotensin 1 receptor
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneBinding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL302579 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL303647 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
726 15 1 9 8.1 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL306340 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
692 17 2 8 6.9 CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL309790 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
733 15 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL311018 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
725 15 1 9 7.7 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1
CHEMBL70867 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
768 16 2 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL71286 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2435824 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
469 9 2 4 6.4 CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL329099 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
654 10 1 7 6.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1
CHEMBL293511 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
524 7 1 6 5.4 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL58291 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assayInhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay
544 7 1 7 5.8 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL158795 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
451 7 1 6 5.5 CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1
CHEMBL63998 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
530 11 3 7 4.4 CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL367569 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
572 2 2 7 5.6 CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3
CHEMBL7550 agtr1_rabit Rabbit Yes 9.5 IC50 = 0.3 nM Bind
Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aortaInhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL343634 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
739 13 2 8 8.1 CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL92533 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
648 9 1 8 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL279629 agtrb_rat Rat No 9.5 IC50 = 0.3 nM Bind
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtrb_rat Rat No 9.5 IC50 = 0.3 nM Bind
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat brain tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL1185398 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1
CHEMBL411487 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
690 10 1 8 7.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1
CHEMBL316273 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
626 10 1 7 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1
CHEMBL332909 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
723 12 2 8 6.7 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F
CHEMBL339672 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
723 12 2 8 7.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL352629 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
649 13 3 9 5.0 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1
CHEMBL302519 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C
CHEMBL279629 agtrb_rat Rat No 9.5 IC50 = 0.3 nM Bind
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtrb_rat Rat No 9.5 IC50 = 0.3 nM Bind
In vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparationIn vitro binding affinity towards Angiotensin II receptor, type 1 to displace 125I[Sar,Ile] from rat adrenal tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL302519 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
639 12 2 8 6.8 CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C
CHEMBL191 agtr1_human Human Yes 9.5 IC50 = 0.3 nM Bind
Inhibition of angiotensin AT1 receptorInhibition of angiotensin AT1 receptor
422 8 2 6 4.3 CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl
CHEMBL352947 agtr1_rabit Rabbit No 9.5 IC50 = 0.3 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
675 13 2 8 6.8 CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL3640122 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
568 8 1 8 5.2 CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1
CHEMBL436396 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL2337686 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
593 11 2 7 5.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2366020 agtr1_human Human No 9.5 IC50 = 0.3 nM Bind
Displacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysisDisplacement of [125I-Sar1-Ile8]-ANG2 from human Angiotensin 2 type-1 receptor expressed in HEK293 cells after 1 hr by gamma counting analysis
593 11 2 7 5.9 CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL436396 agtr1_rabit Rabbit No 9.5 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL306638 agtr1_human Human No 9.5 IC50 = 0.4 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
735 16 1 9 8.2 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL938 agtr1_human Human Yes 9.5 IC50 = 0.4 nM Bind
Binding affinity to human AT1 receptor by radioligand displacement assayBinding affinity to human AT1 receptor by radioligand displacement assay
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL93226 agtr1_rabit Rabbit No 9.5 IC50 = 0.4 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
512 9 2 6 6.0 CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL436396 agtr1_rabit Rabbit No 9.5 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL97394 agtr1_rabit Rabbit No 9.5 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
662 10 1 9 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1
CHEMBL352502 agtr1_rabit Rabbit No 9.5 IC50 = 0.4 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
666 12 2 8 6.8 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL436396 agtr1_rabit Rabbit No 9.5 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 10 2 9 6.2 CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL340078 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F
CHEMBL340078 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F
CHEMBL317547 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
626 10 1 7 6.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1
CHEMBL320222 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
722 10 1 7 7.4 O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl
CHEMBL125280 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
741 12 2 8 6.9 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL352458 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
656 12 2 9 6.4 CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL340078 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
791 12 2 8 8.0 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F
CHEMBL342492 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340473 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL67801 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
617 16 2 7 7.0 CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1
CHEMBL340473 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL328434 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
680 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1
CHEMBL342492 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
773 13 2 8 8.5 CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL340473 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
723 11 2 10 6.9 CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL122158 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL333224 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338137 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL339722 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL122158 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL333224 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338137 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL122158 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
753 10 2 9 7.3 CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL333224 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
715 10 2 9 6.3 CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338137 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
767 11 2 9 7.7 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL330464 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
664 10 1 7 6.5 C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1
CHEMBL169279 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
689 12 2 9 5.8 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1
CHEMBL284918 agtr1_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL34866 agtr1_human Human No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at angiotensin AT1 receptorAntagonist activity at angiotensin AT1 receptor
501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL307359 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
756 16 2 8 8.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL312301 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
789 16 1 10 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL69839 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
678 17 2 8 6.7 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1
CHEMBL408403 agtrb_rat Rat Yes 9.4 IC50 = 0.4 nM Bind
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
None None None None
CHEMBL7550 agtrb_rat Rat Yes 9.4 IC50 = 0.4 nM Bind
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL2435823 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
455 8 2 4 6.1 CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL408403 agtra_rat Rat Yes 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
None None None None
CHEMBL7550 agtra_rat Rat Yes 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL938 agtr1_human Human Yes 9.4 IC50 = 0.4 nM Bind
Displacement of [125I][Sar, Ile]-ATII from human recombinant AT1 receptor expressed in HEK293 cellsDisplacement of [125I][Sar, Ile]-ATII from human recombinant AT1 receptor expressed in HEK293 cells
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL938 agtr1_human Human Yes 9.4 IC50 = 0.4 nM Bind
Displacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [125I][Sar1,Ile8]-AT2 from human recombinant AT1 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL327191 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
702 10 1 8 6.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1
CHEMBL329089 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
638 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1
CHEMBL97020 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
712 10 1 7 7.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1
CHEMBL444065 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
715 13 2 10 5.5 CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL173643 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Inhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aortaInhibition of [125I]-Sar1-Ile8-Ang II binding to Angiotensin II receptor type 1 from rabbit aorta
541 8 2 7 5.5 CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL139325 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL141592 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338889 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338434 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was present in the assay mixture.
747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338889 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL316904 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1
CHEMBL139325 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
753 12 2 8 7.8 CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL141592 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
679 11 1 9 6.4 CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338889 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
719 11 2 9 6.8 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL342605 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338434 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL1951143 agtr1_rabit Rabbit Yes 9.4 IC50 = 0.4 nM Funct
Antagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challengeAntagonist activity at angiotensin 2 receptor type 1 in New Zealand White rabbit descending thoracic aorta rings assessed as inhibition of angiotensin 2-induced contraction preincubated for 30 mins prior angiotensin 2 challenge
501 9 1 7 4.2 CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
CHEMBL334145 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Funct
Antagonist activity at angiotensin AT1 receptor in rabbit aortaAntagonist activity at angiotensin AT1 receptor in rabbit aorta
478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL334145 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
478 9 2 6 5.0 CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL338434 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL97068 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
630 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1
CHEMBL342605 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
739 12 2 8 7.2 CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL338434 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
747 13 2 9 7.6 CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL279629 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL279629 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL279629 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL279629 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL327988 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
688 10 1 8 7.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1
CHEMBL339256 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
757 12 2 8 7.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F
CHEMBL341369 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
743 12 2 9 6.9 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL279629 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL354080 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
647 11 3 8 6.1 CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1
CHEMBL121907 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122401 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL284918 agtrb_rat Rat No 9.4 IC50 = 0.4 nM Bind
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL34866 agtrb_rat Rat No 9.4 IC50 = 0.4 nM Bind
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
501 7 2 8 3.4 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1
CHEMBL121907 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122401 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL339605 agtr1_human Human No 9.4 IC50 = 0.4 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
685 11 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL121907 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
733 12 2 9 6.6 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122401 agtr1_rabit Rabbit No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
815 13 2 8 7.6 CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1
CHEMBL292150 agtr1_rabit Rabbit No 9.4 IC50 = 0.5 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL292150 agtr1_rabit Rabbit No 9.4 IC50 = 0.5 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL292150 agtr1_rabit Rabbit No 9.4 IC50 = 0.5 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL331455 agtr1_human Human No 9.4 IC50 = 0.5 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
705 12 2 9 6.4 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F
CHEMBL292150 agtr1_rabit Rabbit No 9.4 IC50 = 0.5 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL292150 agtr1_rabit Rabbit No 9.4 IC50 = 0.5 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
630 9 1 8 6.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1
CHEMBL90011 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
492 9 2 6 5.7 CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL74767 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
Compound was tested for inhibition against Angiotensin II receptor, type 1Compound was tested for inhibition against Angiotensin II receptor, type 1
437 9 3 6 3.1 CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C
CHEMBL340367 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
591 13 1 6 8.6 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1
CHEMBL4128926 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I][Sar1,Ile8]-AT-II from human recombinant AT1 receptor after 120 mins by scintillation counting analysis
583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12
CHEMBL329942 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1
CHEMBL1017 agtr1_human Human Yes 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after
514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2
CHEMBL1017 agtr1_human Human Yes 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation countingDisplacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting
514 7 1 5 7.3 CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2
CHEMBL122969 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
480 13 1 5 5.2 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1
CHEMBL125725 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
536 12 2 8 4.6 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1
CHEMBL307008 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
703 14 1 9 8.2 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1
CHEMBL72595 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
739 15 1 9 7.9 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F
CHEMBL74573 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL25585 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
536 9 3 7 5.2 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL90774 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
580 9 2 6 7.3 CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL71253 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
612 13 1 7 7.7 CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C
CHEMBL7550 agtr1_rabit Rabbit Yes 9.3 IC50 = 0.5 nM Bind
In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL279629 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit adrenal tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL350554 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membraneIn vitro displacement of 125I-[Sar1, Ile8] from AT1 receptors in rabbit aorta membrane
666 11 1 8 6.4 CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL162148 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aortaIn vitro inhibitory activity against Angiotensin II receptor, type 1 to displace 125I-Sar,Ile8-AII in rabbit aorta
545 10 1 7 5.0 CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL124771 agtr1_human Human No 9.3 IC50 = 0.5 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
729 11 2 9 6.6 CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL338888 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL67921 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
605 13 2 8 6.4 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1
CHEMBL338888 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL338888 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
685 11 2 9 6.4 CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL281386 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
484 9 2 6 4.9 CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL263191 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
665 13 3 8 5.2 CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F
CHEMBL124903 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL123084 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl
CHEMBL124903 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL124903 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
719 11 2 9 6.2 CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.3 IC50 = 0.5 nM Bind
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL7550 agtr1_rabit Rabbit Yes 9.3 IC50 = 0.5 nM Funct
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
409 5 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL263452 agtr1_rabit Rabbit No 9.3 IC50 = 0.5 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
683 10 2 7 6.4 CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1
CHEMBL332897 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Funct
Antagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile responseAntagonist activity at angiotensin AT1 receptor in rabbit aorta assessed as reduction of angiotensin 2-induced contractile response
512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL332897 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
512 9 2 6 6.1 CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL279629 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL97539 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
In vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparationIn vitro binding affinity towards angiotensin-1 receptor to displace 125I[Sar,Ile] from rabbit brain tissue preparation
634 10 1 7 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL339004 agtr1_human Human No 9.3 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
751 14 2 8 7.2 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1
CHEMBL353980 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
Tested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membraneTested in vitro for binding affinity against Angiotensin II receptor, type 1 in rabbit aortic membrane
681 12 3 8 7.2 CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1
CHEMBL342843 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344387 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL122157 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL122157 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.
701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL316655 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
612 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1
CHEMBL330165 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
648 10 1 7 6.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1
CHEMBL339722 agtr1_human Human No 9.3 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
715 13 2 10 6.1 CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL342843 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
649 10 2 8 6.1 CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344387 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
683 10 2 8 6.5 CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL122157 agtr1_rabit Rabbit No 9.3 IC50 = 0.6 nM Bind
Antagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptorAntagonist activity at Oryctolagus cuniculus (rabbit) aortic AT1 receptor
701 9 2 9 5.8 CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL71125 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
787 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F
CHEMBL73876 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F
CHEMBL73876 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
663 11 2 8 5.9 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F
CHEMBL938 agtr1_human Human Yes 9.2 IC50 = 0.6 nM Bind
Inhibition of human angiotensin II AT1 receptorInhibition of human angiotensin II AT1 receptor
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL26614 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aortaDisplacement of [125I]Sar1-Ile8-AII (without BSA) from type 1 Angiotensin II receptor of rabbit aorta
564 9 1 7 5.5 CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL316482 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
630 12 1 8 6.3 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1
CHEMBL122443 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
536 12 2 8 4.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1
CHEMBL124925 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
534 12 1 6 5.9 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1
CHEMBL341295 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
520 12 1 6 5.6 CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1
CHEMBL304065 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
679 13 1 9 6.7 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1
CHEMBL419073 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
772 16 2 8 7.8 CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL71220 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
753 16 1 9 8.3 CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL72099 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
727 16 1 9 8.6 CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1
CHEMBL74236 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL938 agtr1_human Human Yes 9.2 IC50 = 0.6 nM Bind
Binding affinity to human angiotensin AT1 receptor by radioligand displacement assayBinding affinity to human angiotensin AT1 receptor by radioligand displacement assay
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL92472 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
546 9 2 6 6.7 CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL307757 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
598 12 1 7 7.4 CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL448476 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
633 10 2 7 8.3 CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL71925 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranesIn vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes
633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL97465 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
710 11 1 7 7.9 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1
CHEMBL71925 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
Inhibition of Angiotensin II receptor, type 1Inhibition of Angiotensin II receptor, type 1
633 10 2 7 8.3 CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL313868 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aortaIn vitro ability to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta
735 13 2 8 7.1 CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F
CHEMBL74442 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
665 11 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL344811 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL344811 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
747 14 1 8 7.4 CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1
CHEMBL93886 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
554 10 2 6 7.0 CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL1182768 agtr1_rabit Rabbit Yes 9.2 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
654 10 1 8 6.6 CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F
CHEMBL321367 agtr1_rabit Rabbit No 9.2 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
634 10 1 7 5.6 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1
CHEMBL339040 agtr1_human Human No 9.2 IC50 = 0.6 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
699 12 2 9 6.2 CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL62269 agtrb_rat Rat No 9.2 IC50 = 0.7 nM Bind
Tested for binding affinity against angiotensin II receptor in rat adrenal cortexTested for binding affinity against angiotensin II receptor in rat adrenal cortex
473 8 1 8 1.9 CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL35381 agtrb_rat Rat No 9.2 IC50 = 0.7 nM Bind
In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)In vitro ability to displace the specific binding of [125I]-A II from receptors in rat liver membrane(type 1 receptor)
511 7 2 8 3.8 CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)c2ccccc2C(=O)O)s1
CHEMBL938 agtr1_human Human Yes 9.2 IC50 = 0.7 nM Bind
Displacement of radiolabeled saralasin from human AT1 receptorDisplacement of radiolabeled saralasin from human AT1 receptor
911 25 12 12 -2.5 C[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC2=CN=CN2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
CHEMBL120457 agtr1_rabit Rabbit No 9.2 IC50 = 0.7 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
532 8 2 6 6.0 CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL98453 agtr1_rabit Rabbit No 9.2 IC50 = 0.7 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
796 10 1 8 7.8 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1
CHEMBL336180 agtr1_rabit Rabbit No 9.2 IC50 = 0.7 nM Bind
In vitro binding affinity for angiotensin II AT1 receptor in rabbit aortaIn vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta
488 7 1 6 4.5 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1
CHEMBL329858 agtr1_rabit Rabbit No 9.2 IC50 = 0.7 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
652 10 1 7 6.4 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1
CHEMBL1016 agtr1_human Human Yes 9.2 IC50 = 0.7 nM Bind
Displacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation countingDisplacement of [3H]-Angiotensin 2 from human AT1 receptor transfected in CHOK1 cells preincubated for 30 mins with bovine serum albumin followed by radioligand addition by liquid scintillation counting
440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O
CHEMBL338740 agtr1_rabit Rabbit No 9.2 IC50 = 0.7 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
532 8 2 6 6.3 CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL126111 agtr1_human Human No 9.2 IC50 = 0.7 nM Bind
Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)Antagonist activity at angiotensin 2 type-1 receptor (unknown origin)
520 12 1 6 5.6 CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1
CHEMBL4278280 agtr1_human Human No 9.2 IC50 = 0.7 nM Funct
Antagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assayAntagonist activity at type-1 angiotensin 2 receptor (unknown origin) by calcium mobilizing assay
543 9 1 7 4.9 CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1
CHEMBL344407 agtr1_rabit Rabbit No 9.2 IC50 = 0.7 nM Bind
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
445 5 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1
CHEMBL2435829 agtr1_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysisDisplacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin 2 AT1 receptor (unknown origin) after 180 mins by gamma counting analysis
457 7 2 5 5.9 CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1
CHEMBL344407 agtr1_rabit Rabbit No 9.2 IC50 = 0.7 nM Bind
Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.
445 5 1 6 4.2 CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1
CHEMBL259843 agtr1_human Human No 9.2 IC50 = 0.7 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of human adrenal membrane
693 11 2 9 5.5 CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL319353 agtr1_rabit Rabbit No 9.1 IC50 = 0.7 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
702 10 1 7 7.5 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1
CHEMBL321363 agtr1_rabit Rabbit No 9.1 IC50 = 0.7 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
718 10 1 8 7.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1
CHEMBL122273 agtr1_human Human No 9.1 IC50 = 0.7 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
751 12 2 8 6.6 CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1
CHEMBL408403 agtr1_human Human Yes 9.1 IC50 = 0.7 nM Bind
Displacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation countingDisplacement of [3H]-Asp-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-ValTyr-Ile-His-Pro-Phe-OH Tris(hydrotrifluoroacetate) from human AT1 receptor transfected in CHO cells co-expressing Galpha16-mtAEQ after 2 hrs by liquid scintillation counting
None None None None
CHEMBL306361 agtr1_rabit Rabbit No 9.1 IC50 = 0.7 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
635 11 3 8 5.2 CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1
CHEMBL419483 agtr1_rabit Rabbit No 9.1 IC50 = 0.7 nM Bind
Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albuminAntagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin
526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL70100 agtr1_human Human No 9.1 IC50 = 0.7 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
769 16 1 9 8.4 CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1
CHEMBL122224 agtr1_rabit Rabbit No 9.1 IC50 = 0.7 nM Bind
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
513 11 1 5 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1
CHEMBL419483 agtr1_rabit Rabbit No 9.1 IC50 = 0.7 nM Funct
In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without using bovine serum albumin (BSA)
526 10 1 10 4.2 CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL330463 agtr1_rabit Rabbit No 9.1 IC50 = 0.7 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
664 11 1 8 6.2 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1
CHEMBL339113 agtr1_human Human No 9.1 IC50 = 0.7 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
719 11 2 9 6.8 CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F
CHEMBL25585 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Ability to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitroAbility to displace [125I]Sar1-Ile8-AII from angiotensin II receptor, type 1 in rabbit aorta in presence of 0.2% bovine serum albumin (BSA) was determined in vitro
536 9 3 7 5.2 CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL122017 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1
533 11 1 5 7.4 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1
CHEMBL409058 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
616 12 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1
CHEMBL97557 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
659 10 1 8 6.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1
CHEMBL340632 agtr1_human Human No 9.1 IC50 = 0.8 nM Bind
In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.In vitro inhibitory activity against angiotensin II receptor type 1, in human adrenal membrane preparations.
713 13 2 9 6.6 CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1
CHEMBL3640129 agtr1_human Human No 9.1 IC50 = 0.8 nM Bind
Binding Assay: Binding assay using human AT1.Binding Assay: Binding assay using human AT1.
612 9 1 10 4.9 CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1
CHEMBL1667998 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
470 8 1 5 5.8 CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1
CHEMBL94002 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
546 9 2 6 6.7 CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL76821 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
In vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membraneIn vivo inhibitory concentration against Angiotensin II receptor, type 1 of rabbit aorta membrane
663 10 2 8 6.1 CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F
CHEMBL2425239 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Antagonist activity at AT1 receptor in rabbit aorta membranesAntagonist activity at AT1 receptor in rabbit aorta membranes
626 9 1 11 4.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1
CHEMBL19018 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL19018 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL19018 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparationTested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rabbit aorta AT1 receptor preparation
519 8 1 7 5.3 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL306435 agtr1_human Human No 9.1 IC50 = 0.8 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
699 14 1 10 6.9 CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1
CHEMBL74069 agtr1_human Human No 9.1 IC50 = 0.8 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
731 15 1 9 8.8 CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL74514 agtr1_human Human No 9.1 IC50 = 0.8 nM Bind
Binding affinity for Angiotensin II receptor, type 1Binding affinity for Angiotensin II receptor, type 1
753 16 1 9 8.5 CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F
CHEMBL315104 agtrb_rat Rat No 9.1 IC50 = 0.8 nM Bind
Binding affinity for rat angiotensin II receptor, type 1Binding affinity for rat angiotensin II receptor, type 1
423 6 1 6 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL337086 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Binding affinity to angiotensin AT1 receptor in rabbit aortic ringsBinding affinity to angiotensin AT1 receptor in rabbit aortic rings
520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1
CHEMBL278305 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
628 11 1 8 5.1 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1
CHEMBL278977 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1
654 10 1 8 5.0 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1
CHEMBL315104 agtra_rat Rat No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membraneDisplacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane
423 6 1 6 4.9 CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL333800 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Funct
Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1
508 10 2 7 5.4 CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1
CHEMBL335722 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Funct
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
595 11 1 7 6.1 CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1
CHEMBL337086 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Funct
In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.
520 5 1 6 6.3 CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1
CHEMBL449648 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
In vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membraneIn vitro binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane
524 7 1 6 5.3 CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1
CHEMBL327563 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
612 10 1 7 5.7 CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1
CHEMBL329759 agtr1_rabit Rabbit No 9.1 IC50 = 0.8 nM Bind
In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AIIIn vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII
626 9