Ligand source activities (1 row/activity)





Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
164617688 187937 0 None 416 2 Human 11.0 pEC50 = 11.0 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4847536 187937 0 None 416 2 Human 11.0 pEC50 = 11.0 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028449 187937 0 None 416 2 Human 11.0 pEC50 = 11.0 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164622954 187981 0 None 245 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4871708 187981 0 None 245 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028726 187981 0 None 245 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164625303 188004 0 None 316 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4873082 188004 0 None 316 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028871 188004 0 None 316 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
164617772 187939 0 None 173 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848793 187939 0 None 173 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028458 187939 0 None 173 2 Human 10.9 pEC50 = 10.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 368 7 5 5 2.6 CC(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164615126 187920 0 None 104 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4854569 187920 0 None 104 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028293 187920 0 None 104 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
156010908 177758 0 None 2238 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4634131 177758 0 None 2238 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4651173 177758 0 None 2238 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1cccc(O)c1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
164623230 187986 0 None 1479 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4865710 187986 0 None 1479 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028744 187986 0 None 1479 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
164618278 187942 0 None 389 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848018 187942 0 None 389 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028489 187942 0 None 389 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccccc1CCC(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164615492 187925 0 None 120 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848704 187925 0 None 120 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028319 187925 0 None 120 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164623105 187983 0 None 47 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4862449 187983 0 None 47 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028738 187983 0 None 47 2 Human 10.8 pEC50 = 10.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccc(Cl)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164611794 187891 0 None 131 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4854261 187891 0 None 131 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028104 187891 0 None 131 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1cccc(O)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164612025 187893 0 None 2454 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4860454 187893 0 None 2454 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028117 187893 0 None 2454 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
164618895 187950 0 None 95 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868938 187950 0 None 95 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028525 187950 0 None 95 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164610792 187884 0 None 134 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4855974 187884 0 None 134 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028040 187884 0 None 134 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 380 7 4 4 3.6 Cc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
11504295 2878 40 None 1047 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1021/acs.jmedchem.0c01195
4814 2878 40 None 1047 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1021/acs.jmedchem.0c01195
7543 2878 40 None 1047 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1021/acs.jmedchem.0c01195
CHEMBL605846 2878 40 None 1047 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1021/acs.jmedchem.0c01195
DB09080 2878 40 None 1047 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at beta2 adrenoceptor (unknown origin)Agonist activity at beta2 adrenoceptor (unknown origin)
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1021/acs.jmedchem.0c01195
9957764 88279 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 503 11 6 6 3.6 COc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1 10.1016/j.bmcl.2007.09.031
CHEMBL236039 88279 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 503 11 6 6 3.6 COc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1 10.1016/j.bmcl.2007.09.031
11259765 85583 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 462 11 5 5 3.4 CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.04.081
CHEMBL230486 85583 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 462 11 5 5 3.4 CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.04.081
11621158 16523 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 575 12 6 7 3.6 CC(C)(Cc1cccc(CC(=O)NCc2ccc(O)cc2Cl)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1242943 16523 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 575 12 6 7 3.6 CC(C)(Cc1cccc(CC(=O)NCc2ccc(O)cc2Cl)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
155517986 169640 0 None 478630 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4445289 169640 0 None 478630 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
155517986 169640 0 None 478630 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4445289 169640 0 None 478630 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
164621302 187966 0 None 120 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4863282 187966 0 None 120 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028641 187966 0 None 120 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1cccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
164623918 187993 0 None 199 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 374 7 4 4 2.8 O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4872480 187993 0 None 199 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 374 7 4 4 2.8 O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5028793 187993 0 None 199 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 374 7 4 4 2.8 O=c1ccc2c(C(O)CNCCCc3cc(F)cc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
44434130 88282 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 487 10 5 5 3.9 C[C@H](Cc1ccc2[nH]c(C(=O)N(C)Cc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL236041 88282 0 None - 1 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 487 10 5 5 3.9 C[C@H](Cc1ccc2[nH]c(C(=O)N(C)Cc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
164615222 187922 0 None 91 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4857267 187922 0 None 91 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028301 187922 0 None 91 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccccc1CCC(C)(C)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164622827 187979 0 None 26 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868585 187979 0 None 26 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028721 187979 0 None 26 2 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 400 7 4 4 3.9 CC(C)(CCc1cccc(Cl)c1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
11455274 16545 0 None - 1 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 525 12 5 6 3.3 CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243189 16545 0 None - 1 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 525 12 5 6 3.3 CC(C)(Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
164624634 188000 0 None 131 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868684 188000 0 None 131 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028836 188000 0 None 131 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1cccc(F)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
156014115 177715 0 None 58 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4635163 177715 0 None 58 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4650951 177715 0 None 58 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccccc1CCC(C)(C)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
11214499 85585 0 None - 1 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 516 11 5 5 4.3 C[C@H](Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm1005989
CHEMBL230490 85585 0 None - 1 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 516 11 5 5 4.3 C[C@H](Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm1005989
164608750 187874 0 None 181 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4846631 187874 0 None 181 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5027923 187874 0 None 181 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3cccc(F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
156015148 177710 0 None 208 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4646881 177710 0 None 208 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4650929 177710 0 None 208 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
164620479 187959 0 None 288 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4863847 187959 0 None 288 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028596 187959 0 None 288 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1cccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
11249243 16542 0 None - 1 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 511 12 5 6 2.9 C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243158 16542 0 None - 1 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 511 12 5 6 2.9 C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
156015482 177677 0 None 204 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmc.2019.115178
CHEMBL4641262 177677 0 None 204 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmc.2019.115178
CHEMBL4650664 177677 0 None 204 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1cccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmc.2019.115178
164619360 187953 0 None 371 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4868763 187953 0 None 371 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028547 187953 0 None 371 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 370 7 4 4 3.0 CC(CCc1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164623544 187989 0 None 2754 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 406 7 4 4 3.5 O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4872653 187989 0 None 2754 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 406 7 4 4 3.5 O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5028764 187989 0 None 2754 2 Human 10.6 pEC50 = 10.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 406 7 4 4 3.5 O=c1ccc2c(C(O)CNCCCc3cccc(C(F)(F)F)c3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
164612078 187894 0 None 64 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4848617 187894 0 None 64 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028119 187894 0 None 64 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 8 4 5 2.9 COc1ccccc1CC[C@@H](C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
156014817 177729 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4642770 177729 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4650993 177729 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccccc1CCC(C)(C)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
164617235 187934 0 None 251 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4848775 187934 0 None 251 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028422 187934 0 None 251 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 396 8 4 5 3.3 COc1ccc(CCC(C)(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
156013777 177773 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4636255 177773 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4651241 177773 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1cccc(O)c1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
10390417 167202 0 None - 1 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 480 10 6 7 3.0 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3nccs3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL430361 167202 0 None - 1 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 480 10 6 7 3.0 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3nccs3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
49864395 15461 0 None - 1 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulationAgonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulation
ChEMBL 400 7 4 6 3.1 O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@@H]3CCC[C@H]3OCc3ccccc3)c2s1 10.1016/j.bmcl.2010.06.136
CHEMBL1221680 15461 0 None - 1 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulationAgonist activity at beta 2 in human A431 cells adrenoceptor assessed as cAMP accumulation
ChEMBL 400 7 4 6 3.1 O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@@H]3CCC[C@H]3OCc3ccccc3)c2s1 10.1016/j.bmcl.2010.06.136
11477877 16568 0 None - 1 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 517 12 5 6 3.3 C[C@H](Cc1cccc(CC(=O)NCC2CCCCC2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243348 16568 0 None - 1 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 517 12 5 6 3.3 C[C@H](Cc1cccc(CC(=O)NCC2CCCCC2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
13121366 176881 0 None 457 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 370 7 4 5 2.8 CC(C)(CCc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4638864 176881 0 None 457 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 370 7 4 5 2.8 CC(C)(CCc1ccccc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
164612262 187895 0 None 190 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4853372 187895 0 None 190 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028127 187895 0 None 190 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccc(Cl)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
164614743 187915 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4860764 187915 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028269 187915 0 None 134 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1ccccc1Cl)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
156014962 177675 0 None 229 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmc.2019.115178
CHEMBL4645203 177675 0 None 229 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmc.2019.115178
CHEMBL4650644 177675 0 None 229 2 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccc(CCC(C)(C)NC[C@H](O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmc.2019.115178
155536314 171609 0 None 6025 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4473515 171609 0 None 6025 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
155536314 171609 0 None 6025 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4473515 171609 0 None 6025 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3cccc(O)c3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
164620585 187960 0 None 616 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4866766 187960 0 None 616 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028602 187960 0 None 616 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 382 7 5 5 3.0 CC(C)(CCc1ccc(O)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
44434126 88281 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 519 11 6 6 4.3 CSc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1 10.1016/j.bmcl.2007.09.031
CHEMBL236040 88281 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 519 11 6 6 4.3 CSc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1 10.1016/j.bmcl.2007.09.031
10027868 144359 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 474 10 6 6 2.9 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccn3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL391006 144359 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 474 10 6 6 2.9 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccn3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
164618813 187949 0 None 275 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4865833 187949 0 None 275 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028523 187949 0 None 275 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 366 7 4 4 3.2 Cc1ccc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
164623433 187987 0 None 380 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL4870623 187987 0 None 380 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
CHEMBL5028756 187987 0 None 380 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.ejmech.2021.113697
156014983 177755 0 None 724 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4644638 177755 0 None 724 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4651152 177755 0 None 724 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 386 7 5 6 2.5 CC(C)(CCc1ccc(O)cc1)NCC(O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
11261001 16546 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 525 13 5 6 2.9 C[C@H](Cc1cccc(CC(=O)NCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243190 16546 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 525 13 5 6 2.9 C[C@H](Cc1cccc(CC(=O)NCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
11489605 16553 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 541 13 5 7 2.9 COc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1 10.1021/jm1005989
CHEMBL1243256 16553 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 541 13 5 7 2.9 COc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1 10.1021/jm1005989
155533625 171311 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4469364 171311 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 366 7 4 4 3.3 CC(C)(CCc1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
155564766 174916 0 None 181 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
CHEMBL4577508 174916 0 None 181 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
11489574 16550 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 539 14 5 6 3.3 C[C@H](Cc1cccc(CC(=O)NCCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243222 16550 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 539 14 5 6 3.3 C[C@H](Cc1cccc(CC(=O)NCCCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
155536813 171640 0 None 263 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4473790 171640 0 None 263 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
164624092 187996 0 None 794 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 442 10 4 7 2.9 COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL4865514 187996 0 None 794 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 442 10 4 7 2.9 COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL5028807 187996 0 None 794 2 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 442 10 4 7 2.9 COc1cc(CCC(C)NCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
2419 3407 80 None 17 6 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2019.115178
5152 3407 80 None 17 6 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2019.115178
559 3407 80 None 17 6 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2019.115178
CHEMBL1263 3407 80 None 17 6 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2019.115178
DB00938 3407 80 None 17 6 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2019.115178
11699773 16537 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 569 12 6 7 3.6 Cc1cc(O)cc(C)c1CNC(=O)Cc1cccc(CC(C)(C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1 10.1021/jm1005989
CHEMBL1243101 16537 0 None - 1 Human 10.4 pEC50 = 10.4 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 569 12 6 7 3.6 Cc1cc(O)cc(C)c1CNC(=O)Cc1cccc(CC(C)(C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1 10.1021/jm1005989
164626310 188010 0 None 346 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL4874945 188010 0 None 346 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
CHEMBL5028930 188010 0 None 346 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 356 7 4 4 2.6 O=c1ccc2c(C(O)CNCCCc3ccc(F)cc3)ccc(O)c2[nH]1 10.1016/j.ejmech.2021.113697
11398811 16556 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 555 14 5 7 3.3 CCOc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1 10.1021/jm1005989
CHEMBL1243285 16556 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 555 14 5 7 3.3 CCOc1ccccc1CNC(=O)Cc1cccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NS(C)(=O)=O)c2)c1 10.1021/jm1005989
155543358 174201 0 None 102 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4561253 174201 0 None 102 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccccc3O)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
156015401 177696 0 None 251 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmc.2019.115178
CHEMBL4645694 177696 0 None 251 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmc.2019.115178
CHEMBL4650809 177696 0 None 251 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1cccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)c1 10.1016/j.bmc.2019.115178
156015798 177703 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmc.2019.115178
CHEMBL4649233 177703 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmc.2019.115178
CHEMBL4650858 177703 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 400 8 4 6 2.8 COc1ccc(CCC(C)(C)NCC(O)c2cc(O)cc3c2OCC(=O)N3)cc1 10.1016/j.bmc.2019.115178
44434125 145578 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 473 10 6 5 3.6 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL391946 145578 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 473 10 6 5 3.6 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
44237865 57923 0 None - 1 Guinea pig 10.3 pEC50 = 10.3 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 500 11 6 5 3.9 O=C(NCCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682213 57923 0 None - 1 Guinea pig 10.3 pEC50 = 10.3 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 500 11 6 5 3.9 O=C(NCCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
155557083 173969 0 None 724 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4556022 173969 0 None 724 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 354 7 5 5 2.2 O=c1ccc2c(C(O)CNCCCc3ccc(O)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
10389119 88326 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 451 10 6 5 3.2 C[C@H](Cc1ccc2[nH]c(C(=O)NCC3CCC3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL236251 88326 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 451 10 6 5 3.2 C[C@H](Cc1ccc2[nH]c(C(=O)NCC3CCC3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
155564340 174851 0 None 263 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 493 11 5 5 4.9 CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C 10.1016/j.bmc.2018.10.043
CHEMBL4576089 174851 0 None 263 2 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 493 11 5 5 4.9 CC(CC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)CC(C)(C)C 10.1016/j.bmc.2018.10.043
44434127 88179 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 509 10 6 5 3.8 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(F)cccc3F)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL235612 88179 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 509 10 6 5 3.8 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(F)cccc3F)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
3466 4078 38 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 378 8 4 5 2.4 OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C 10.1021/jm1005989
37990 4078 38 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 378 8 4 5 2.4 OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C 10.1021/jm1005989
CHEMBL1243407 4078 38 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 378 8 4 5 2.4 OC(c1ccc(c(c1)NS(=O)(=O)C)O)CNC(Cc1ccccc1)(C)C 10.1021/jm1005989
1499 2060 43 None -72 36 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2019.115178
3779 2060 43 None -72 36 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2019.115178
536 2060 43 None -72 36 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2019.115178
CHEMBL434 2060 43 None -72 36 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2019.115178
DB01064 2060 43 None -72 36 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2019.115178
11376125 16561 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 539 12 5 6 3.5 Cc1ccc(CNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)cc1C 10.1021/jm1005989
CHEMBL1243317 16561 0 None - 1 Human 10.3 pEC50 = 10.3 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 539 12 5 6 3.5 Cc1ccc(CNC(=O)Cc2cccc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(NS(C)(=O)=O)c3)c2)cc1C 10.1021/jm1005989
164614249 187910 0 None 295 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4859591 187910 0 None 295 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028241 187910 0 None 295 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccccc1CCCNCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
10324803 89165 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 533 12 6 7 3.6 COc1cccc(OC)c1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1 10.1016/j.bmcl.2007.09.031
CHEMBL237501 89165 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 533 12 6 7 3.6 COc1cccc(OC)c1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O)c3ccc(O)c(CO)c3)ccc2[nH]1 10.1016/j.bmcl.2007.09.031
10390752 145723 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 487 10 6 5 4.1 C[C@H](Cc1ccc2[nH]c(C(=O)N[C@H](C)c3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL392056 145723 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 487 10 6 5 4.1 C[C@H](Cc1ccc2[nH]c(C(=O)N[C@H](C)c3ccccc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
16049087 63752 0 None 125 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 448 13 4 7 3.3 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807817 63752 0 None 125 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 448 13 4 7 3.3 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCSCCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
9892481 69890 11 None -3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2014.04.095
CHEMBL1940832 69890 11 None -3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2014.04.095
90645347 112021 0 None 7 3 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 12 6 7 5.6 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298987 112021 0 None 7 3 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 578 12 6 7 5.6 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
9892481 69890 11 None -3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2014.04.069
CHEMBL1940832 69890 11 None -3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2014.04.069
9892481 69890 11 None -3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
CHEMBL1940832 69890 11 None -3 4 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 435 12 6 6 3.0 O=CNc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
11420492 154661 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 492 10 5 5 3.8 C[C@H](Cc1cccc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm1005989
CHEMBL402501 154661 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 492 10 5 5 3.8 C[C@H](Cc1cccc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1021/jm1005989
155564079 174838 0 None 97 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 442 8 4 4 4.9 CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4575759 174838 0 None 97 2 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 442 8 4 4 4.9 CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
11456127 16567 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 593 12 5 6 4.6 CC(C)(Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243347 16567 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 593 12 5 6 4.6 CC(C)(Cc1cccc(CC(=O)NCc2ccc(Cl)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
44237667 57920 0 None - 1 Guinea pig 10.2 pEC50 = 10.2 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 458 8 6 5 3.7 O=C(Nc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682210 57920 0 None - 1 Guinea pig 10.2 pEC50 = 10.2 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 458 8 6 5 3.7 O=C(Nc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
2419 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.09.031
5152 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.09.031
559 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.09.031
CHEMBL1263 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.09.031
DB00938 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.09.031
2419 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.04.081
5152 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.04.081
559 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.04.081
CHEMBL1263 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.04.081
DB00938 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2007.04.081
2419 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm1005989
5152 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm1005989
559 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm1005989
CHEMBL1263 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm1005989
DB00938 3407 80 None 17 6 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm1005989
45269924 193777 0 None - 1 Guinea pig 10.1 pEC50 = 10.1 Functional
Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contractionAgonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction
ChEMBL 283 6 5 6 -0.1 CC(C)(C)NC[C@@H](O)c1ccc(OB(O)O)c(CO)c1 10.1016/j.ejmech.2008.12.016
CHEMBL552398 193777 0 None - 1 Guinea pig 10.1 pEC50 = 10.1 Functional
Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contractionAgonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction
ChEMBL 283 6 5 6 -0.1 CC(C)(C)NC[C@@H](O)c1ccc(OB(O)O)c(CO)c1 10.1016/j.ejmech.2008.12.016
164615474 187924 0 None 61 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL4847767 187924 0 None 61 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
CHEMBL5028315 187924 0 None 61 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 4 3.5 CC(CCc1cccc(Cl)c1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.ejmech.2021.113697
155548071 173177 0 None 131 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 338 7 4 4 2.5 O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4536813 173177 0 None 131 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 338 7 4 4 2.5 O=c1ccc2c(C(O)CNCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
155567283 175397 0 None 588 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.bmc.2018.10.043
CHEMBL4588479 175397 0 None 588 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 368 8 4 5 2.5 COc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.bmc.2018.10.043
155548668 173211 0 None - 1 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 478 8 4 4 5.1 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4537644 173211 0 None - 1 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 478 8 4 4 5.1 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
2419 3407 80 None 17 6 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
5152 3407 80 None 17 6 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
559 3407 80 None 17 6 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
CHEMBL1263 3407 80 None 17 6 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
DB00938 3407 80 None 17 6 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2018.10.043
16049088 63753 0 None 100 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 448 13 4 7 3.3 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807818 63753 0 None 100 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 448 13 4 7 3.3 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
16049028 63754 0 None 50 3 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 462 14 4 7 3.7 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807819 63754 0 None 50 3 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 462 14 4 7 3.7 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
11592062 111965 0 None 25 3 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1 10.1016/j.bmcl.2014.04.095
CHEMBL3298325 111965 0 None 25 3 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1 10.1016/j.bmcl.2014.04.095
11169365 112020 0 None 22 3 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 11 6 7 4.0 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298986 112020 0 None 22 3 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 11 6 7 4.0 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
155513474 169173 0 None 83 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 478 8 4 4 5.1 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4438531 169173 0 None 83 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 478 8 4 4 5.1 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
164622775 187978 0 None 120226 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 428 10 4 7 2.5 COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL4867311 187978 0 None 120226 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 428 10 4 7 2.5 COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
CHEMBL5028718 187978 0 None 120226 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 428 10 4 7 2.5 COc1cc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc(OC)c1OC 10.1016/j.ejmech.2021.113697
11504295 2878 40 None 1047 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
4814 2878 40 None 1047 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
7543 2878 40 None 1047 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
CHEMBL605846 2878 40 None 1047 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
DB09080 2878 40 None 1047 2 Human 10.1 pEC50 = 10.1 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 386 7 4 6 2.4 COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C 10.1016/j.ejmech.2021.113697
44237615 57922 0 None - 1 Guinea pig 10.1 pEC50 = 10.1 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 486 10 6 5 3.5 O=C(NCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682212 57922 0 None - 1 Guinea pig 10.1 pEC50 = 10.1 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 486 10 6 5 3.5 O=C(NCCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
11707090 16533 0 None - 1 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 609 12 6 7 4.3 CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)c(O)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243068 16533 0 None - 1 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 609 12 6 7 4.3 CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)c(O)c(Cl)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
164623583 187991 0 None 316 2 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL4873280 187991 0 None 316 2 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
CHEMBL5028767 187991 0 None 316 2 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 352 7 4 4 2.8 Cc1ccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1016/j.ejmech.2021.113697
11247541 85537 0 None - 1 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 434 11 5 5 2.6 O=C(Cc1cccc(CCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NCc1ccccc1 10.1016/j.bmcl.2007.04.081
CHEMBL230203 85537 0 None - 1 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 434 11 5 5 2.6 O=C(Cc1cccc(CCNC[C@H](O)c2ccc(O)c(CO)c2)c1)NCc1ccccc1 10.1016/j.bmcl.2007.04.081
44425580 85584 0 None - 1 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 448 11 5 5 3.0 C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.04.081
CHEMBL230487 85584 0 None - 1 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMPAgonist activity at human recombinant beta-2 adrenoceptor expressed in CHO cells assessed as elevation of cAMP
ChEMBL 448 11 5 5 3.0 C[C@H](Cc1cccc(CC(=O)NCc2ccccc2)c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.04.081
57334265 70514 0 None - 1 Guinea pig 10.0 pEC50 = 10 Functional
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction
ChEMBL 538 13 4 8 3.4 COc1ccc(C2=NN(CCCCNC[C@H](O)c3ccc(O)c(NC=O)c3)C(=O)C3CCCCC23)cc1OC 10.1016/j.bmcl.2012.01.013
CHEMBL1951067 70514 0 None - 1 Guinea pig 10.0 pEC50 = 10 Functional
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction
ChEMBL 538 13 4 8 3.4 COc1ccc(C2=NN(CCCCNC[C@H](O)c3ccc(O)c(NC=O)c3)C(=O)C3CCCCC23)cc1OC 10.1016/j.bmcl.2012.01.013
12065 621 21 None 6 2 Human 10.0 pEC50 = 10 Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
45483813 621 21 None 6 2 Human 10.0 pEC50 = 10 Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
CHEMBL579394 621 21 None 6 2 Human 10.0 pEC50 = 10 Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 370 6 4 5 2.7 Cc1ccccc1CC(C)(C)NCC(c1c2c(c(cc1)O)NC(=O)CO2)O 10.1016/j.bmcl.2009.10.013
13345218 195545 0 None 8 2 Human 10.0 pEC50 = 10 Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 372 6 5 6 2.1 CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL568272 195545 0 None 8 2 Human 10.0 pEC50 = 10 Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 372 6 5 6 2.1 CC(C)(Cc1ccc(O)cc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
16049024 63755 0 None 79 3 Human 10.0 pEC50 = 10 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 498 13 4 7 4.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3cccc4ccccc34)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807820 63755 0 None 79 3 Human 10.0 pEC50 = 10 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 498 13 4 7 4.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCSCCOCCc3cccc4ccccc34)c2s1 10.1016/j.bmcl.2011.05.097
118737358 118560 0 None - 1 Human 10.0 pEC50 = 10 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 13 6 8 5.8 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1021/jm501915g
CHEMBL3426706 118560 0 None - 1 Human 10.0 pEC50 = 10 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 13 6 8 5.8 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1021/jm501915g
10239722 111966 0 None 11 3 Human 10.0 pEC50 = 10 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298326 111966 0 None 11 3 Human 10.0 pEC50 = 10 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccc(CN)cc1 10.1016/j.bmcl.2014.04.095
66796015 111968 0 None 35 3 Human 10.0 pEC50 = 10 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 474 11 6 7 3.2 NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298328 111968 0 None 35 3 Human 10.0 pEC50 = 10 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 474 11 6 7 3.2 NCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
10180590 69888 0 None 707 2 Human 10.0 pEC50 = 10 Functional
Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 422 11 6 6 2.9 OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
CHEMBL1940830 69888 0 None 707 2 Human 10.0 pEC50 = 10 Functional
Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 422 11 6 6 2.9 OCc1cc([C@@H](O)CNCCc2ccc(NC[C@H](O)c3ccccc3)cc2)ccc1O 10.1016/j.bmcl.2011.11.072
105 3405 84 None -8 3 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
2083 3405 84 None -8 3 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
558 3405 84 None -8 3 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
CHEMBL714 3405 84 None -8 3 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
DB01001 3405 84 None -8 3 Human 10.0 pEC50 = 10.0 Functional
Agonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysisAgonist activity at beta2 adrenoceptor (unknown origin) expressed in HEK293 cells assessed as cAMP accumulation incubated for 60 mins by microplate reader analysis
ChEMBL 239 4 4 4 1.3 OCc1cc(ccc1O)C(CNC(C)(C)C)O 10.1021/acs.jmedchem.1c02006
10392857 88231 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 552 11 7 7 2.2 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL235818 88231 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 552 11 7 7 2.2 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(S(N)(=O)=O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
3083544 462 46 None -1 4 Guinea pig 9.9 pEC50 = 9.9 Functional
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2012.01.013
4943 462 46 None -1 4 Guinea pig 9.9 pEC50 = 9.9 Functional
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2012.01.013
7479 462 46 None -1 4 Guinea pig 9.9 pEC50 = 9.9 Functional
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2012.01.013
CHEMBL1363 462 46 None -1 4 Guinea pig 9.9 pEC50 = 9.9 Functional
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2012.01.013
DB01274 462 46 None -1 4 Guinea pig 9.9 pEC50 = 9.9 Functional
Agonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contractionAgonist activity at beta2 adrenoceptor in guinea pig assessed as relaxation of histamine-induced tracheal ring contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2012.01.013
16049026 63756 0 None 25 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 432 13 4 7 2.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807821 63756 0 None 25 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 432 13 4 7 2.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3ccccc3)c2s1 10.1016/j.bmcl.2011.05.097
16049029 63757 0 None 25 2 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 482 13 4 7 3.7 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3cccc4ccccc34)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807822 63757 0 None 25 2 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 482 13 4 7 3.7 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCOCCc3cccc4ccccc34)c2s1 10.1016/j.bmcl.2011.05.097
10461973 118551 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 655 15 6 8 4.9 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)NCCCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
CHEMBL3426697 118551 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 655 15 6 8 4.9 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)NCCCCCNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
9871386 111779 4 None 8 4 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
CHEMBL3290999 111779 4 None 8 4 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.095
90645344 111964 0 None 7 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN 10.1016/j.bmcl.2014.04.095
CHEMBL3298324 111964 0 None 7 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1CN 10.1016/j.bmcl.2014.04.095
56943545 111970 0 None 28 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 13 6 7 4.0 NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298330 111970 0 None 28 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 502 13 6 7 4.0 NCCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
11180293 112016 0 None 22 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 543 12 6 8 3.1 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
CHEMBL3298897 112016 0 None 22 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 543 12 6 8 3.1 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCNCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
46832232 14100 0 None 39 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 467 16 4 6 4.5 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O 10.1021/jm100326d
CHEMBL1085837 14100 0 None 39 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 467 16 4 6 4.5 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O 10.1021/jm100326d
CHEMBL1198923 14100 0 None 39 3 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 467 16 4 6 4.5 OCc1cc([C@@H](O)CNCCCCCCOCCOCc2cccc3ccccc23)ccc1O 10.1021/jm100326d
10217757 111778 0 None 10 4 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 497 12 5 6 5.2 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
CHEMBL3290998 111778 0 None 10 4 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 497 12 5 6 5.2 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
9871386 111779 4 None 8 4 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
CHEMBL3290999 111779 4 None 8 4 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 521 10 5 6 5.5 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1ccccc1 10.1016/j.bmcl.2014.04.069
57398384 69891 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 459 10 6 6 3.2 O=c1ccc2c([C@@H](O)CNCCc3ccc(NC[C@H](O)c4ccccc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2011.11.072
CHEMBL1940833 69891 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassayAgonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay
ChEMBL 459 10 6 6 3.2 O=c1ccc2c([C@@H](O)CNCCc3ccc(NC[C@H](O)c4ccccc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2011.11.072
156015656 177768 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 378 7 4 5 2.3 O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1 10.1016/j.bmc.2019.115178
CHEMBL4639822 177768 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 378 7 4 5 2.3 O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1 10.1016/j.bmc.2019.115178
CHEMBL4651230 177768 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 378 7 4 5 2.3 O=C1COc2c(cc(O)cc2C(O)CNCCCc2cc(F)cc(F)c2)N1 10.1016/j.bmc.2019.115178
53323515 57924 0 None - 1 Guinea pig 9.9 pEC50 = 9.9 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 515 10 7 6 2.5 NC(=O)c1cccc(CNC(=O)Nc2cccc(CCNCC(O)c3ccc(O)c4[nH]c(=O)ccc34)c2)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682214 57924 0 None - 1 Guinea pig 9.9 pEC50 = 9.9 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 515 10 7 6 2.5 NC(=O)c1cccc(CNC(=O)Nc2cccc(CCNCC(O)c3ccc(O)c4[nH]c(=O)ccc34)c2)c1 10.1016/j.bmcl.2010.12.096
46938907 16530 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 609 12 6 7 4.3 CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)cc(Cl)c2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243035 16530 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 609 12 6 7 4.3 CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)cc(Cl)c2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
155524038 170324 0 None 120 2 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 414 8 4 4 4.2 O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4454489 170324 0 None 120 2 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 414 8 4 4 4.2 O=c1ccc2c(C(O)CNCCCc3ccc(-c4ccccc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
2419 3407 80 None 17 6 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
5152 3407 80 None 17 6 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
559 3407 80 None 17 6 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
CHEMBL1263 3407 80 None 17 6 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
DB00938 3407 80 None 17 6 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.ejmech.2021.113697
156020412 177774 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 446 8 4 5 4.3 CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4648525 177774 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 446 8 4 5 4.3 CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4651243 177774 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 446 8 4 5 4.3 CC(C)(CC(c1ccccc1)c1ccccc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
155550964 173378 0 None 575 2 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 352 8 4 4 2.9 O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4541263 173378 0 None 575 2 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 352 8 4 4 2.9 O=c1ccc2c(C(O)CNCCCCc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
1499 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
3779 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
536 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
CHEMBL434 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
DB01064 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity against human beta 2 adrenergic receptor (AR), expressed in CHO cellsActivity against human beta 2 adrenergic receptor (AR), expressed in CHO cells
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0101500
1499 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
3779 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
536 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
CHEMBL434 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
DB01064 2060 43 None -72 36 Human 9.8 pEC50 = 9.8 Functional
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP productionActivity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1021/jm0509445
10394806 118552 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 681 12 6 8 5.3 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)N[C@H]1CC[C@H](CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)CC1 10.1021/jm501915g
CHEMBL3426698 118552 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 681 12 6 8 5.3 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)N[C@H]1CC[C@H](CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)CC1 10.1021/jm501915g
118737354 118555 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 703 12 6 8 5.8 Cc1cc(C(=O)NCCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
CHEMBL3426701 118555 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 703 12 6 8 5.8 Cc1cc(C(=O)NCCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
56943518 111969 0 None 25 3 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 488 12 6 7 3.6 NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298329 111969 0 None 25 3 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 488 12 6 7 3.6 NCCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
56943546 111986 0 None 25 3 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 518 14 6 8 3.2 NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298691 111986 0 None 25 3 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 518 14 6 8 3.2 NCCOCCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
24901144 69986 0 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944691 69986 0 None -1 5 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
10288976 66247 0 None 10 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 17 6 6 3.9 Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835862 66247 0 None 10 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 17 6 6 3.9 Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852543 66247 0 None 10 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 487 17 6 6 3.9 Cc1cc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)cc(NC(N)=O)c1 10.1016/j.bmc.2011.08.043
9849126 12333 0 None -3 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL1185969 12333 0 None -3 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
CHEMBL443435 12333 0 None -3 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 507 18 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(NC=O)c2)c1 10.1021/jm801016j
9891927 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL446840 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483200 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL483201 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
9891927 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL446840 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL483200 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL483201 183615 6 None 5 4 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 494 17 5 7 2.8 NS(=O)(=O)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
155551133 173424 0 None 446 2 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 340 7 4 5 1.9 O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
CHEMBL4542430 173424 0 None 446 2 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 340 7 4 5 1.9 O=c1ccc2c(C(O)CNCCOc3ccccc3)ccc(O)c2[nH]1 10.1016/j.bmc.2018.10.043
44434128 148607 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 489 10 7 6 3.3 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL394339 148607 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 489 10 7 6 3.3 C[C@H](Cc1ccc2[nH]c(C(=O)NCc3ccc(O)cc3)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
11534330 16527 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 575 12 6 7 3.6 CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)ccc2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1243000 16527 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 575 12 6 7 3.6 CC(C)(Cc1cccc(CC(=O)NCc2cc(Cl)ccc2O)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
156020206 177767 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 7 5 6 1.7 O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1 10.1016/j.bmc.2019.115178
CHEMBL4648663 177767 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 7 5 6 1.7 O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1 10.1016/j.bmc.2019.115178
CHEMBL4651226 177767 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 7 5 6 1.7 O=C1COc2c(cc(O)cc2C(O)CNCCCc2cccc(O)c2)N1 10.1016/j.bmc.2019.115178
156015463 177776 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 482 8 4 5 4.6 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4640925 177776 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 482 8 4 5 4.6 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
CHEMBL4651254 177776 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 482 8 4 5 4.6 CC(C)(CC(c1ccc(F)cc1)c1ccc(F)cc1)NC[C@H](O)c1cc(O)cc2c1OCC(=O)N2 10.1016/j.bmc.2019.115178
1239 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2011.01.043
3410 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2011.01.043
3465 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2011.01.043
CHEMBL1256786 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2011.01.043
DB00983 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassayAgonist activity at human beta2-adrenoceptor expressed in HEK cells assessed as increase of cAMP level after 10 mins by radioimmunoassay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2011.01.043
56658246 64166 0 None 3 4 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 525 17 5 8 2.9 O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814277 64166 0 None 3 4 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 525 17 5 8 2.9 O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
CHEMBL1814278 64166 0 None 3 4 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 525 17 5 8 2.9 O=c1cc[nH]c(=O)n1-c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.05.064
24901413 70013 0 None 3 4 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12 10.1016/j.bmcl.2011.10.049
CHEMBL1945032 70013 0 None 3 4 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12 10.1016/j.bmcl.2011.10.049
15981386 63219 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hrAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr
ChEMBL 459 12 4 7 2.0 CN(CCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1ccccc1 10.1016/j.bmcl.2011.04.135
CHEMBL1800472 63219 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hrAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr
ChEMBL 459 12 4 7 2.0 CN(CCNC[C@H](O)c1ccc(O)c2[nH]c(=O)sc12)C(=O)CCOCCc1ccccc1 10.1016/j.bmcl.2011.04.135
56663238 63771 0 None 251 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 465 13 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
CHEMBL1807872 63771 0 None 251 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 minsAgonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as stimulation of cAMP accumulation after 60 mins
ChEMBL 465 13 5 7 2.8 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCCOCCNCCc3cccc(Cl)c3)c2s1 10.1016/j.bmcl.2011.05.097
11857427 118547 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 12 6 8 6.1 Cc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1 10.1021/jm501915g
CHEMBL3426693 118547 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 12 6 8 6.1 Cc1cc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1NC(=O)CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1 10.1021/jm501915g
118737350 118548 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 12 6 8 6.1 Cc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
CHEMBL3426694 118548 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 12 6 8 6.1 Cc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
1239 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
3410 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
3465 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
CHEMBL1256786 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
DB00983 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.095
16738927 70015 0 None 31 3 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945034 70015 0 None 31 3 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccn4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
42625823 12570 0 None 251 3 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 576 19 5 7 4.7 O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL1187371 12570 0 None 251 3 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 576 19 5 7 4.7 O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
CHEMBL500782 12570 0 None 251 3 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 576 19 5 7 4.7 O=S(=O)(NC1CCCCC1)c1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm801016j
1239 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
3410 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
3465 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
CHEMBL1256786 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
DB00983 1647 46 None -1 5 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assayAgonist activity at human recombinant beta2 receptor assessed as cAMP accumulation by radioimmunoassay and cell based assay
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2014.04.069
44237612 57921 0 None 4466 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 472 9 6 5 3.4 O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682211 57921 0 None 4466 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 472 9 6 5 3.4 O=C(NCc1ccccc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
44237613 57925 0 None 2754 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 502 10 6 6 3.4 COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682215 57925 0 None 2754 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 502 10 6 6 3.4 COc1ccccc1CNC(=O)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
44237614 57926 0 None 31622 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 490 9 6 5 3.6 O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682216 57926 0 None 31622 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 490 9 6 5 3.6 O=C(NCc1ccc(F)cc1)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
44237669 57927 0 None 7943 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 540 9 6 5 4.7 O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
CHEMBL1682217 57927 0 None 7943 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 540 9 6 5 4.7 O=C(NCc1c(Cl)cccc1Cl)Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmcl.2010.12.096
44237666 57928 0 None 44668 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 548 10 6 5 5.0 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2010.12.096
CHEMBL1682218 57928 0 None 44668 2 Guinea pig 9.7 pEC50 = 9.7 Functional
Agonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxationAgonist activity at beta2 adrenoceptor in guinea pig tracheal rings assessed as vasorelaxation
ChEMBL 548 10 6 5 5.0 O=C(Nc1cccc(CCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)NC(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2010.12.096
45483810 195468 0 None 3 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
CHEMBL567863 195468 0 None 3 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulationAgonist activity at human adrenergic beta 2 expressed in CHO-K1 cells assessed as intracellular cAMP accumulation
ChEMBL 356 6 4 5 2.4 CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2c1OCC(=O)N2 10.1016/j.bmcl.2009.10.013
1499 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2013.11.030
3779 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2013.11.030
536 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2013.11.030
CHEMBL434 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2013.11.030
DB01064 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2013.11.030
11577915 16431 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 591 12 6 7 4.1 CC(C)(Cc1cccc(CC(=O)NCc2ccc3cc(O)ccc3c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1240965 16431 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 591 12 6 7 4.1 CC(C)(Cc1cccc(CC(=O)NCc2ccc3cc(O)ccc3c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
1499 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
3779 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
536 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
CHEMBL434 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
DB01064 2060 43 None -72 36 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulationAgonist activity at human beta2 adrenoreceptor overexpressed in HEK293 cells assessed as cAMP accumulation
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2021.113697
156014685 177771 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 7 5 6 1.7 O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1 10.1016/j.bmc.2019.115178
CHEMBL4636111 177771 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 7 5 6 1.7 O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1 10.1016/j.bmc.2019.115178
CHEMBL4651237 177771 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 358 7 5 6 1.7 O=C1COc2c(cc(O)cc2C(O)CNCCCc2ccccc2O)N1 10.1016/j.bmc.2019.115178
155536173 171596 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 442 8 4 4 4.9 CC(C)(CC(c1ccccc1)c1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
CHEMBL4473349 171596 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 442 8 4 4 4.9 CC(C)(CC(c1ccccc1)c1ccccc1)NCC(O)c1ccc(O)c2[nH]c(=O)ccc12 10.1016/j.bmc.2018.10.043
155527926 170687 0 None 8709 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 451 11 5 5 3.9 CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
CHEMBL4460095 170687 0 None 8709 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 451 11 5 5 3.9 CC(C)CCC(=O)Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1 10.1016/j.bmc.2018.10.043
11714238 16432 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 617 13 6 7 4.6 CC(C)(Cc1cccc(CC(=O)NCc2ccc(-c3ccc(O)cc3)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1240966 16432 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 617 13 6 7 4.6 CC(C)(Cc1cccc(CC(=O)NCc2ccc(-c3ccc(O)cc3)cc2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
11647002 15462 0 None 8 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP levelAgonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level
ChEMBL 400 7 4 6 3.1 O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@H]3CCC[C@@H]3OCc3ccccc3)c2s1 10.1016/j.bmcl.2014.06.014
CHEMBL1221681 15462 0 None 8 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP levelAgonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level
ChEMBL 400 7 4 6 3.1 O=c1[nH]c2c(O)ccc([C@@H](O)CN[C@H]3CCC[C@@H]3OCc3ccccc3)c2s1 10.1016/j.bmcl.2014.06.014
164612026 184787 0 None 776 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 237 4 3 4 1.3 CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1 10.1021/acs.jmedchem.0c01195
CHEMBL4860455 184787 0 None 776 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assayAgonist activity at human beta2 adrenoceptor expressed in HEK293 cells assessed as increase in cAMP accumulation measured after 60 mins by HTRF assay
ChEMBL 237 4 3 4 1.3 CC(C)NC(CO)c1cc(F)c(N)c(C#N)c1 10.1021/acs.jmedchem.0c01195
56672271 66208 0 None -1 4 Guinea pig 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835859 66208 0 None -1 4 Guinea pig 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852407 66208 0 None -1 4 Guinea pig 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
24901144 69986 0 None 1 5 Guinea pig 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944691 69986 0 None 1 5 Guinea pig 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 481 11 5 6 3.6 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4F)c3)c2s1 10.1016/j.bmcl.2011.10.049
57393349 70189 0 None 3 2 Guinea pig 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 523 11 4 5 6.2 C[C@@H](NCc1ccccc1-c1ccc(CCNCCc2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1 10.1016/j.bmcl.2011.10.049
CHEMBL1947151 70189 0 None 3 2 Guinea pig 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 523 11 4 5 6.2 C[C@@H](NCc1ccccc1-c1ccc(CCNCCc2ccc(O)c3[nH]c(=O)sc23)cc1)c1ccccc1 10.1016/j.bmcl.2011.10.049
2419 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
5152 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
559 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
CHEMBL1263 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
DB00938 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.05.064
56672116 66033 0 None 316 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 570 19 5 8 2.4 NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1814276 66033 0 None 316 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 570 19 5 8 2.4 NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
CHEMBL1851624 66033 0 None 316 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human adrenergic beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 570 19 5 8 2.4 NC(=O)CN1C(=O)CN(c2cccc(CCCCOCCCCCCNC[C@H](O)c3ccc(O)c(CO)c3)c2)C1=O 10.1016/j.bmc.2011.05.064
10372836 101925 34 None 6 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 739 13 6 9 6.4 COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
CHEMBL3039518 101925 34 None 6 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 739 13 6 9 6.4 COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(Cl)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
10372344 118541 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 675 12 6 8 5.8 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1021/jm501915g
CHEMBL3426687 118541 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 675 12 6 8 5.8 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1021/jm501915g
10327462 118542 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 709 12 6 8 6.4 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1Cl 10.1021/jm501915g
CHEMBL3426688 118542 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 709 12 6 8 6.4 O=C(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)Nc1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1Cl 10.1021/jm501915g
118737348 118545 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 705 13 6 9 5.8 COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
CHEMBL3426691 118545 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 705 13 6 9 5.8 COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)ccc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
118737351 118549 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 719 13 6 9 6.1 COc1c(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c1C 10.1021/jm501915g
CHEMBL3426695 118549 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 719 13 6 9 6.1 COc1c(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c1C 10.1021/jm501915g
118737355 118556 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 12 5 8 5.5 CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1021/jm501915g
CHEMBL3426702 118556 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 689 12 5 8 5.5 CN(CCN1CCC(OC(=O)Nc2ccccc2-c2ccccc2)CC1)C(=O)c1ccc(CNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)cc1 10.1021/jm501915g
56943515 111952 0 None 7 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 478 13 6 7 3.7 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298213 111952 0 None 7 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 478 13 6 7 3.7 CC(C)(N)COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c(NC=O)c3)cc2)cc1 10.1016/j.bmcl.2014.04.095
10173878 111967 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 459 10 5 6 4.2 CCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
CHEMBL3298327 111967 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 459 10 5 6 4.2 CCOc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1 10.1016/j.bmcl.2014.04.095
24901210 69985 0 None 125 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 497 11 5 6 4.1 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944690 69985 0 None 125 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 497 11 5 6 4.1 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccc4Cl)c3)c2s1 10.1016/j.bmcl.2011.10.049
24901347 69990 0 None 17 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 463 11 5 6 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1944695 69990 0 None 17 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 463 11 5 6 3.5 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3ccc(CNCCc4ccccc4)cc3)c2s1 10.1016/j.bmcl.2011.10.049
24901413 70013 0 None -3 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12 10.1016/j.bmcl.2011.10.049
CHEMBL1945032 70013 0 None -3 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometryAgonist activity at human beta2 adrenoceptor expressed in H292 cells assessed as increase in cAMP accumulation after 60 mins by spectrophotometry
ChEMBL 516 11 6 6 4.3 Cc1cccc2c(CCNCc3ccc(CCNC[C@H](O)c4ccc(O)c5[nH]c(=O)sc45)cc3)c[nH]c12 10.1016/j.bmcl.2011.10.049
2419 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm401532g
5152 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm401532g
559 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm401532g
CHEMBL1263 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm401532g
DB00938 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assayAgonist activity at human beta2 adrenoceptor transfected in CHO cells assessed as cyclic AMP accumulation after 45 mins by fluorescence polarization assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm401532g
156016062 177750 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 356 8 4 5 2.4 O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1 10.1016/j.bmc.2019.115178
CHEMBL4643148 177750 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 356 8 4 5 2.4 O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1 10.1016/j.bmc.2019.115178
CHEMBL4651124 177750 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assayAgonist activity at human beta2 adrenoreceptor overexpressed in human HEK293 cells assessed as cAMP accumulation incubated for 60 mins by HTRF assay
ChEMBL 356 8 4 5 2.4 O=C1COc2c(cc(O)cc2C(O)CNCCCCc2ccccc2)N1 10.1016/j.bmc.2019.115178
2419 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
5152 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
559 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
CHEMBL1263 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
DB00938 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmc.2011.08.043
56672271 66208 0 None 1 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1835859 66208 0 None 1 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
CHEMBL1852407 66208 0 None 1 4 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulationAgonist activity at human beta2 receptor expressed in CHO cells assessed as cAMP accumulation
ChEMBL 530 19 7 7 2.7 NC(=O)CNC(=O)Nc1cccc(CCCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1016/j.bmc.2011.08.043
2419 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
5152 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
559 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
CHEMBL1263 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
DB00938 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assayAgonist activity at human cloned beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation by beta-galactosidase based whole cell assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm801016j
2419 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
5152 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
559 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
CHEMBL1263 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
DB00938 3407 80 None 17 6 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1021/jm100326d
46832509 14097 0 None 50 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 510 18 5 8 2.7 CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1085399 14097 0 None 50 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 510 18 5 8 2.7 CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
CHEMBL1198908 14097 0 None 50 3 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 minsAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as induction of intracellular cAMP accumulation after 30 to 45 mins
ChEMBL 510 18 5 8 2.7 CS(=O)(=O)Nc1cccc(COCCOCCCCCCNC[C@H](O)c2ccc(O)c(CO)c2)c1 10.1021/jm100326d
10006800 88283 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 517 12 6 6 3.6 COc1cccc(CCNC(=O)c2cc3cc(C[C@@H](C)NC[C@H](O)c4ccc(O)c(CO)c4)ccc3[nH]2)c1 10.1016/j.bmcl.2007.09.031
CHEMBL236042 88283 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 517 12 6 6 3.6 COc1cccc(CCNC(=O)c2cc3cc(C[C@@H](C)NC[C@H](O)c4ccc(O)c(CO)c4)ccc3[nH]2)c1 10.1016/j.bmcl.2007.09.031
10256921 144762 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 547 13 6 7 4.0 CC[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(OC)cccc3OC)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
CHEMBL391308 144762 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levelsAgonist activity at human recombinant adrenergic beta-2 receptor expressed in CHO cells assessed as elevation in cAMP levels
ChEMBL 547 13 6 7 4.0 CC[C@H](Cc1ccc2[nH]c(C(=O)NCc3c(OC)cccc3OC)cc2c1)NC[C@H](O)c1ccc(O)c(CO)c1 10.1016/j.bmcl.2007.09.031
11505444 16433 13 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 617 13 6 7 4.6 CC(C)(Cc1cccc(CC(=O)NCc2cccc(-c3ccc(O)cc3)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
CHEMBL1240967 16433 13 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate methodAgonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method
ChEMBL 617 13 6 7 4.6 CC(C)(Cc1cccc(CC(=O)NCc2cccc(-c3ccc(O)cc3)c2)c1)NC[C@H](O)c1ccc(O)c(NS(C)(=O)=O)c1 10.1021/jm1005989
11625619 77266 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assayAgonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assay
ChEMBL 406 6 4 4 3.5 CCc1cc2c(cc1CC)CC(C)(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C2 10.1016/j.bmcl.2012.07.096
CHEMBL2088201 77266 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assayAgonist activity at beta2-adrenoceptor in human bronchial smooth-muscle cell by cAMP assay
ChEMBL 406 6 4 4 3.5 CCc1cc2c(cc1CC)CC(C)(NC[C@H](O)c1ccc(O)c3[nH]c(=O)ccc13)C2 10.1016/j.bmcl.2012.07.096
16735257 85304 0 None 812 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay
ChEMBL 317 7 4 5 2.4 COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1 10.1016/j.bmc.2009.11.062
CHEMBL228992 85304 0 None 812 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay
ChEMBL 317 7 4 5 2.4 COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1 10.1016/j.bmc.2009.11.062
688468 141800 7 None 346 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay
ChEMBL 303 6 5 5 2.1 C[C@H](Cc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc(O)c1 10.1016/j.bmc.2009.11.062
CHEMBL388570 141800 7 None 346 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assayAgonist activity at human beta2 adrenergic receptor expressed in HEK 293 cells assessed as stimulation of cAMP accumulation by protein kinase binding assay
ChEMBL 303 6 5 5 2.1 C[C@H](Cc1ccc(O)cc1)NC[C@H](O)c1cc(O)cc(O)c1 10.1016/j.bmc.2009.11.062
16735257 85304 0 None 812 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
ChEMBL 317 7 4 5 2.4 COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1 10.1016/j.bmc.2013.11.030
CHEMBL228992 85304 0 None 812 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulationAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
ChEMBL 317 7 4 5 2.4 COc1ccc(C[C@@H](C)NC[C@H](O)c2cc(O)cc(O)c2)cc1 10.1016/j.bmc.2013.11.030
155543518 174426 0 None 794 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 457 9 5 5 3.7 O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1 10.1016/j.bmc.2018.10.043
CHEMBL4566727 174426 0 None 794 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 457 9 5 5 3.7 O=C(Nc1cccc(CCCNCC(O)c2ccc(O)c3[nH]c(=O)ccc23)c1)c1ccccc1 10.1016/j.bmc.2018.10.043
1239 1647 46 None -1 5 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
3410 1647 46 None -1 5 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
3465 1647 46 None -1 5 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
CHEMBL1256786 1647 46 None -1 5 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
DB00983 1647 46 None -1 5 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contractionAgonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as inhibition of electrically-stimulated contraction
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)C(CNC(Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.05.064
3083544 462 46 None -1 4 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.08.043
4943 462 46 None -1 4 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.08.043
7479 462 46 None -1 4 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.08.043
CHEMBL1363 462 46 None -1 4 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.08.043
DB01274 462 46 None -1 4 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile responseAgonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmc.2011.08.043
24900685 70014 0 None 3 5 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
CHEMBL1945033 70014 0 None 3 5 Guinea pig 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contractionAgonist activity at beta2 adrenoceptor in guinea pig trachea assessed as reduction in methacholine-induced contraction
ChEMBL 464 11 5 7 2.9 O=c1[nH]c2c(O)ccc([C@@H](O)CNCCc3cccc(CNCCc4ccccn4)c3)c2s1 10.1016/j.bmcl.2011.10.049
3083544 462 46 None 1 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2013.11.028
4943 462 46 None 1 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2013.11.028
7479 462 46 None 1 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2013.11.028
CHEMBL1363 462 46 None 1 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2013.11.028
DB01274 462 46 None 1 4 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at beta2-adrenergic receptor (unknown origin)Agonist activity at beta2-adrenergic receptor (unknown origin)
ChEMBL 344 9 4 5 2.2 O=CNc1cc(ccc1O)[C@H](CN[C@@H](Cc1ccc(cc1)OC)C)O 10.1016/j.bmcl.2013.11.028
118737352 118550 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 719 13 6 9 6.1 COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
CHEMBL3426696 118550 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation countingAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as cAMP accumulation using [125I]cAMP by scintillation counting
ChEMBL 719 13 6 9 6.1 COc1cc(NC(=O)CCN2CCC(OC(=O)Nc3ccccc3-c3ccccc3)CC2)c(C)cc1CNC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 10.1021/jm501915g
1499 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
1499 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
3779 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
3779 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
536 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
536 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
CHEMBL434 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
CHEMBL434 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
DB01064 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.bmc.2018.10.043
DB01064 2060 43 None -72 36 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assayAgonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as increase in cAMP accumulation after 60 mins by HTRF assay
ChEMBL 211 4 4 4 1.1 CC(NCC(c1ccc(c(c1)O)O)O)C 10.1016/j.ejmech.2018.04.041
2419 3407 80 None 17 6 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
5152 3407 80 None 17 6 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
559 3407 80 None 17 6 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
CHEMBL1263 3407 80 None 17 6 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
DB00938 3407 80 None 17 6 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 415 16 4 5 4.1 OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O 10.1016/j.bmcl.2014.04.095
56943485 112011 0 None 12 3 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 544 12 5 8 3.6 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
CHEMBL3298831 112011 0 None 12 3 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor expressed in cells by cAMP accumulation assay
ChEMBL 544 12 5 8 3.6 O=c1ccc2c([C@@H](O)CNCCc3ccc(Nc4ccc(OCCN5CCOCC5)cc4)cc3)ccc(O)c2[nH]1 10.1016/j.bmcl.2014.04.095
11592062 111965 0 None 25 3 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1 10.1016/j.bmcl.2014.04.095
CHEMBL3298325 111965 0 None 25 3 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assayAgonist activity at human beta2 adrenergic receptor in human BEAS-2B cells by cAMP accumulation assay
ChEMBL 550 11 6 7 5.0 COc1ccc(Nc2ccc(CCNC[C@H](O)c3ccc(O)c4[nH]c(=O)ccc34)cc2)cc1-c1cccc(CN)c1 10.1016/j.bmcl.2014.04.095<