Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL778 ada2c_human Human Yes 9.3 EC50 = 0.5 nM Funct
Agonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C
CHEMBL17860 ada2c_human Human Yes 8.9 EC50 = 1.4 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
258 3 1 3 2.8 CC(C1=NCCN1)Oc1c(Cl)cccc1Cl
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL2089156 ada2c_human Human No 8.7 EC50 = 2.0 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL1956195 ada2c_human Human No 8.7 EC50 = 2.0 nM Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL2089156 ada2c_human Human No 8.7 EC50 = 2.0 nM Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL297827 ada2c_human Human No 8.7 EC50 = 2.0 nM Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
296 4 1 3 3.5 C(=C/c1ccccc1)\C[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1
CHEMBL242693 ada2c_human Human No 8.0 EC50 = 10 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL1956192 ada2c_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1
CHEMBL1956192 ada2c_human Human Yes 8.0 EC50 = 10 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1
CHEMBL495096 ada2c_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
258 4 1 3 3.1 CC(Oc1ccccc1C1CCCC1)C1=NCCN1
CHEMBL242693 ada2c_human Human No 8.0 EC50 = 10 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL1276247 ada2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 4 3.2 C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL14208 ada2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
248 5 1 4 2.2 CC(C)Oc1ccccc1OC(C)C1=NCCN1
CHEMBL156336 ada2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 4 1 3 2.0 CCc1ccccc1OC(C)C1=NCCN1
CHEMBL1956201 ada2c_human Human Yes 7.0 EC50 = 100 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 4 1 4 1.3 CC(Oc1ccccc1C=O)C1=NCCN1
CHEMBL306792 ada2c_human Human No 7.0 EC50 = 100 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1
CHEMBL222928 ada2c_human Human Yes 7.0 EC50 = 100 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL2431280 ada2c_human Human No 6.0 EC50 = 1000 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
232 5 1 4 1.6 c1ccc(OC2CC2)c(OCC2=NCCN2)c1
CHEMBL492639 ada2c_human Human No 6.0 EC50 = 1000 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
261 6 1 5 1.8 CCO/N=C/c1ccccc1OC(C)C1=NCCN1
CHEMBL371300 ada2c_human Human Yes 5.0 EC50 = 10000 nM Funct
Activity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayActivity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assay
191 2 2 4 1.1 C[C@H](N)Cn1ncc2ccc(O)cc21
CHEMBL1956196 ada2c_human Human No 5.0 EC50 = 10000 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
234 5 1 4 1.9 CCOc1ccccc1OC(C)C1=NCCN1
CHEMBL74283 ada2c_human Human Yes 7.0 EC50 = 104.7 nM Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2
CHEMBL432155 ada2c_human Human No 7.0 EC50 = 110 nM Funct
Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cellsEffective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells
230 2 3 4 2.3 Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2
CHEMBL242265 ada2c_human Human No 7.0 EC50 = 112.2 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL242265 ada2c_human Human No 7.0 EC50 = 112.2 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 3 3.1 C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL71479 ada2c_human Human No 6.0 EC50 = 1122.0 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
267 4 2 5 0.8 Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1
CHEMBL1956194 ada2c_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
230 4 1 3 2.5 C=C(C)c1ccccc1OC(C)C1=NCCN1
CHEMBL3892351 ada2c_human Human No 6.9 EC50 = 114.8 nM Bind
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
217 5 2 3 2.1 CCCc1ccccc1NCC1=NCCN1
CHEMBL1079 ada2c_human Human Yes 5.9 EC50 = 1231 nM Funct
Agonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
253 1 2 6 1.7 Clc1ccc2nsnc2c1NC1=NCCN1
CHEMBL1276219 ada2c_human Human No 6.9 EC50 = 125.9 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL1276219 ada2c_human Human No 6.9 EC50 = 125.9 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL493675 ada2c_human Human Yes 6.9 EC50 = 125.9 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
233 4 2 5 1.3 CC(Oc1ccccc1/C=N/O)C1=NCCN1
CHEMBL295186 ada2c_human Human No 7.9 EC50 = 13.8 nM Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
270 3 1 3 2.6 c1ccc(C[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1
CHEMBL286080 ada2c_human Human Yes 5.9 EC50 = 1380.4 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
255 1 3 3 2.4 Oc1cc2CCNCC(c2cc1O)c1ccccc1
CHEMBL49137 ada2c_human Human Yes 7.9 EC50 = 14.1 nM Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12
CHEMBL337862 ada2c_human Human No 6.8 EC50 = 147.9 nM Bind
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
251 4 2 3 2.8 c1ccc(-c2ccccc2NCC2=NCCN2)cc1
CHEMBL3588911 ada2c_human Human Yes 3.8 EC50 = 147910.8 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
243 5 1 3 2.7 Cc1ccccc1Cn1ccnc1CNC(C)C
CHEMBL70692 ada2c_human Human No 7.8 EC50 = 15.9 nM Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1
CHEMBL569933 ada2c_human Human No 6.8 EC50 = 154.9 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
218 4 1 3 2.1 CCCc1ccccc1COC1=NCCN1
CHEMBL13917 ada2c_human Human No 6.8 EC50 = 154.9 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
218 5 1 3 2.0 CCCc1ccccc1OCC1=NCCN1
CHEMBL222928 ada2c_human Human Yes 6.8 EC50 = 158.5 nM Funct
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL3961335 ada2c_human Human No 6.8 EC50 = 158.5 nM Bind
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
215 5 2 3 1.8 C=CCc1ccccc1NCC1=NCCN1
CHEMBL222973 ada2c_human Human No 5.8 EC50 = 1584.9 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 3 3.4 Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1
CHEMBL1956191 ada2c_human Human No 6.8 EC50 = 166.0 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
224 3 1 3 2.1 CC(Oc1ccccc1Cl)C1=NCCN1
CHEMBL3588902 ada2c_human Human Yes 6.8 EC50 = 173.8 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
187 3 2 2 2.3 Cc1ccccc1NCc1cnc[nH]1
CHEMBL396013 ada2c_human Human No 7.7 EC50 = 18.6 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL396013 ada2c_human Human No 7.7 EC50 = 18.6 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1
CHEMBL1276139 ada2c_human Human No 6.7 EC50 = 186.2 nM Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1
CHEMBL289480 ada2c_human Human Yes 6.7 EC50 = 190.6 nM Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1
CHEMBL1956202 ada2c_human Human No 6.7 EC50 = 199.5 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 4 1 4 1.7 CC(=O)c1ccccc1OC(C)C1=NCCN1
CHEMBL72958 ada2c_human Human Yes 5.7 EC50 = 1995.3 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
248 4 3 4 0.2 NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O
CHEMBL74467 ada2c_human Human No 5.7 EC50 = 1995.3 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
271 4 2 5 0.6 CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1
CHEMBL75030 ada2c_human Human Yes 8.7 EC50 = 2.2 nM Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
216 1 1 3 2.0 c1ccc2c(c1)CCCC2NC1=NCCO1
CHEMBL70751 ada2c_human Human No 8.6 EC50 = 2.8 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1
CHEMBL451229 ada2c_human Human No 7.7 EC50 = 20.9 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
272 4 1 3 3.5 CC(Oc1ccccc1C1CCCCC1)C1=NCCN1
CHEMBL296660 ada2c_human Human No 7.7 EC50 = 21.4 nM Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
222 3 1 3 2.2 CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1
CHEMBL3904276 ada2c_human Human No 7.7 EC50 = 21.9 nM Bind
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
189 3 2 3 1.4 Cc1ccccc1NCC1=NCCN1
CHEMBL51358 ada2c_human Human Yes 6.7 EC50 = 223.9 nM Bind
Agonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2c-AR expressed in CHO cells assessed as rate of acidification after 240 mins by cytosensor microphysiometric analysis
209 3 2 3 1.8 Clc1ccccc1NCC1=NCCN1
CHEMBL2431281 ada2c_human Human No 6.6 EC50 = 234.4 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 3 2.0 c1ccc(OCC2=NCCN2)c(CC2CC2)c1
CHEMBL306377 ada2c_human Human No 7.6 EC50 = 24.6 nM Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
230 1 1 3 2.4 c1ccc2c(c1)CCCC2NC1=NCCCO1
CHEMBL576078 ada2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
232 4 1 3 2.7 CCCc1ccccc1C(C)OC1=NCCN1
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1
CHEMBL1278084 ada2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 4 2.8 C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1
CHEMBL2431282 ada2c_human Human No 7.6 EC50 = 25.1 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
232 5 1 3 2.4 CCCc1ccccc1OC(C)C1=NCCN1
CHEMBL1276140 ada2c_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 3 2.2 C=CCc1ccccc1O[C@@H](C)C1=NCCN1
CHEMBL1278085 ada2c_human Human No 5.6 EC50 = 2511.9 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 4 2.8 C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL50720 ada2c_human Human No 7.6 EC50 = 26.9 nM Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
286 5 1 3 3.5 c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1
CHEMBL1204386 ada2c_human Human No 5.6 EC50 = 2691.5 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1
CHEMBL222933 ada2c_human Human No 5.6 EC50 = 2691.5 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
264 3 1 3 2.8 c1ccc(-c2ccccc2C2OC2C2=NCCN2)cc1
CHEMBL155866 ada2c_human Human No 7.6 EC50 = 27.5 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
218 3 1 3 2.1 Cc1cccc(C)c1OC(C)C1=NCCN1
CHEMBL157955 ada2c_human Human No 7.6 EC50 = 27.5 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
246 5 1 3 2.6 CCc1cccc(CC)c1OC(C)C1=NCCN1
CHEMBL1190038 ada2c_human Human No 7.6 EC50 = 28.2 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1
CHEMBL540035 ada2c_human Human No 7.6 EC50 = 28.2 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1
CHEMBL1194763 ada2c_human Human No 7.6 EC50 = 28.2 nM Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1
CHEMBL553276 ada2c_human Human No 7.6 EC50 = 28.2 nM Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1
CHEMBL576819 ada2c_human Human No 5.5 EC50 = 2884.0 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
190 2 1 3 1.5 Cc1ccccc1COC1=NCCN1
CHEMBL844 ada2c_human Human Yes 8.5 EC50 = 3.4 nM Funct
Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cellsEffective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells
291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1
CHEMBL72753 ada2c_human Human Yes 7.5 EC50 = 30.9 nM Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12
CHEMBL1956200 ada2c_human Human No 6.5 EC50 = 316.2 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
268 4 1 5 0.9 CC(Oc1ccccc1S(C)(=O)=O)C1=NCCN1
CHEMBL2089155 ada2c_human Human No 6.5 EC50 = 316.2 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL2089155 ada2c_human Human No 6.5 EC50 = 316.2 nM Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL522151 ada2c_human Human No 5.5 EC50 = 3162.3 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
280 2 1 4 2.5 c1ccc(-c2cccc3c2OC(C2=NCCN2)CO3)cc1
CHEMBL2087646 ada2c_human Human Yes 5.5 EC50 = 3162.3 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
194 3 1 4 1.9 NCCSc1nc2ccccc2o1
CHEMBL117094 ada2c_human Human Yes 5.5 EC50 = 3162.3 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1
CHEMBL544290 ada2c_human Human Yes 5.5 EC50 = 3162.3 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
253 4 2 5 0.5 CS(=O)(=O)c1ccccc1NCC1=NCCN1
CHEMBL1327 ada2c_human Human Yes 3.5 EC50 = 338844.2 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
256 3 1 3 2.9 OC(Cn1ccnc1)c1ccc(Cl)cc1Cl
CHEMBL1215 ada2c_human Human Yes 6.5 EC50 = 340 nM Funct
Agonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
167 3 3 3 0.6 CNC[C@@H](c1cccc(c1)O)O
CHEMBL3588904 ada2c_human Human No 5.5 EC50 = 3467.4 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
261 4 1 3 3.8 c1cncc(-c2ccccc2NCc2ccncc2)c1
CHEMBL1276220 ada2c_human Human No 7.5 EC50 = 35.5 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL1276220 ada2c_human Human No 7.5 EC50 = 35.5 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 4 1 3 2.3 C[C@H](Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL495097 ada2c_human Human No 5.5 EC50 = 3548.1 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
323 7 1 5 3.0 CC(Oc1ccccc1/C=N/OCc1ccccc1)C1=NCCN1
CHEMBL223830 ada2c_human Human No 6.4 EC50 = 363.1 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 3 3.4 Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1
CHEMBL242693 ada2c_human Human No 7.4 EC50 = 38 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL576623 ada2c_human Human No 7.4 EC50 = 39.8 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
230 3 1 3 2.6 CC(OC1=NCCN1)c1ccccc1C1CC1
CHEMBL1276218 ada2c_human Human No 7.4 EC50 = 39.8 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL373535 ada2c_human Human No 7.4 EC50 = 39.8 nM Funct
Agonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation
267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1
CHEMBL1276218 ada2c_human Human No 7.4 EC50 = 39.8 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 4 1 3 2.3 CC(Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL13852 ada2c_human Human Yes 6.4 EC50 = 398.1 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1
CHEMBL266613 ada2c_human Human No 6.4 EC50 = 398.1 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 4 1 3 2.6 CC(Oc1ccccc1C(C)C)C1=NCCN1
CHEMBL13852 ada2c_human Human Yes 6.4 EC50 = 398.1 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
216 4 1 3 1.9 C1CN=C(N1)COc1ccccc1C1CC1
CHEMBL310335 ada2c_human Human No 8.4 EC50 = 4.1 nM Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
210 3 1 3 2.3 CCC[C@H]1CCCCC1NC1=NCCO1
CHEMBL297752 ada2c_human Human No 8.4 EC50 = 4.1 nM Funct
Alpha-2C adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha-2C adrenergic receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
210 3 1 3 2.3 CCC[C@H]1CCCC[C@@H]1NC1=NCCO1
CHEMBL74114 ada2c_human Human No 6.4 EC50 = 446.7 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
271 4 2 5 0.6 CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL374584 ada2c_human Human No 7.3 EC50 = 46.8 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL1956197 ada2c_human Human No 7.3 EC50 = 47.9 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1
CHEMBL1956197 ada2c_human Human No 7.3 EC50 = 47.9 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
246 5 1 4 2.0 CC(Oc1ccccc1OC1CC1)C1=NCCN1
CHEMBL3588905 ada2c_human Human No 3.3 EC50 = 478630.1 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
264 5 2 3 2.8 c1ccc(-c2nc(CNCc3cccnc3)c[nH]2)cc1
CHEMBL72768 ada2c_human Human No 8.3 EC50 = 5.6 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1
CHEMBL117248 ada2c_human Human Yes 8.3 EC50 = 5.6 nM Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1
CHEMBL540542 ada2c_human Human Yes 8.3 EC50 = 5.6 nM Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1
CHEMBL570973 ada2c_human Human No 7.3 EC50 = 50.1 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
230 4 1 3 2.5 C=CCc1ccccc1C(C)OC1=NCCN1
CHEMBL495095 ada2c_human Human Yes 7.3 EC50 = 50.1 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1
CHEMBL373535 ada2c_human Human No 7.3 EC50 = 50.1 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1
CHEMBL495095 ada2c_human Human Yes 7.3 EC50 = 50.1 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1
CHEMBL495095 ada2c_human Human Yes 7.3 EC50 = 50.1 nM Funct
Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysisAgonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1
CHEMBL495095 ada2c_human Human Yes 7.3 EC50 = 50.1 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
230 5 1 3 2.2 C=CCc1ccccc1OC(C)C1=NCCN1
CHEMBL373535 ada2c_human Human No 7.3 EC50 = 50.1 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
267 4 1 4 2.5 CC(Oc1ccccc1-c1cccnc1)C1=NCCN1
CHEMBL222371 ada2c_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
281 4 2 4 2.7 CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1
CHEMBL442815 ada2c_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
247 5 1 5 1.4 CO/N=C/c1ccccc1OC(C)C1=NCCN1
CHEMBL419448 ada2c_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
271 4 2 5 0.6 CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1
CHEMBL70973 ada2c_human Human No 5.3 EC50 = 5011.9 nM Funct
Agonist potency at Alpha-2C adrenergic receptor expressed in CHO cellsAgonist potency at Alpha-2C adrenergic receptor expressed in CHO cells
267 5 2 5 0.9 CCS(=O)(=O)c1ccccc1NCC1=NCCN1
CHEMBL761 ada2c_human Human Yes 7.3 EC50 = 55.0 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2
CHEMBL134 ada2c_human Human Yes 7.3 EC50 = 55.0 nM Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl
CHEMBL70676 ada2c_human Human Yes 7.3 EC50 = 55.0 nM Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
339 1 2 5 1.6 Ic1c(NC2=NCCN2)ccc2nccnc12
CHEMBL134 ada2c_human Human Yes 7.3 EC50 = 56 nM Funct
Agonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl
CHEMBL157206 ada2c_human Human No 7.3 EC50 = 56.2 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
270 7 1 3 2.9 C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1
CHEMBL437314 ada2c_human Human Yes 5.3 EC50 = 5660 nM Funct
Activity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assayActivity at adrenergic Alpha-2C receptor expressed in rat-mouse hybrid NH108-15 cell by adenylyl cyclase assay
191 2 2 4 1.1 C[C@@H](N)Cn1ncc2ccc(O)cc21
CHEMBL134 ada2c_human Human Yes 7.2 EC50 = 57.5 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl
CHEMBL128168 ada2c_human Human Yes 7.2 EC50 = 57.5 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL128168 ada2c_human Human Yes 7.2 EC50 = 57.5 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL128168 ada2c_human Human Yes 7.2 EC50 = 57.5 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL128168 ada2c_human Human Yes 7.2 EC50 = 57.5 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL223829 ada2c_human Human No 7.2 EC50 = 58.9 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
272 4 1 4 3.2 CC(Oc1ccccc1-c1cccs1)C1=NCCN1
CHEMBL1276248 ada2c_human Human No 8.2 EC50 = 6.3 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 4 3.2 C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL308570 ada2c_human Human Yes 8.2 EC50 = 6.6 nM Funct
Effective concentration at Alpha-2C adrenergic receptor from CHO-C4 cellsEffective concentration at Alpha-2C adrenergic receptor from CHO-C4 cells
231 2 2 4 2.2 Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2
CHEMBL223836 ada2c_human Human No 7.2 EC50 = 60.3 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1
CHEMBL223836 ada2c_human Human No 7.2 EC50 = 60.3 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1
CHEMBL48341 ada2c_human Human No 7.2 EC50 = 60.3 nM Funct
Alpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMPAlpha2c receptor agonism measured as ability to inhibit forskolin-stimulated synthesis of cAMP
298 5 1 3 3.4 c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1
CHEMBL14107 ada2c_human Human No 7.2 EC50 = 61.7 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
216 5 1 3 1.8 C=CCc1ccccc1OCC1=NCCN1
CHEMBL570863 ada2c_human Human No 7.2 EC50 = 63.1 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
204 2 1 3 2.0 Cc1ccccc1C(C)OC1=NCCN1
CHEMBL1956198 ada2c_human Human No 6.2 EC50 = 631.0 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
232 5 1 4 2.0 C=COc1ccccc1OC(C)C1=NCCN1
CHEMBL70740 ada2c_human Human No 5.2 EC50 = 6309.6 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
279 3 2 5 0.8 O=S1(=O)CCCc2cccc(NCC3=NCCN3)c21
CHEMBL3588909 ada2c_human Human Yes 3.2 EC50 = 630957.3 nM Funct
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysisAgonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic calcium mobilization measured for 40 secs by fluorometric analysis
242 4 2 3 2.4 NCC(=O)Nc1ccccc1Oc1ccccc1
CHEMBL72724 ada2c_human Human No 8.1 EC50 = 7.9 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
289 4 2 4 2.8 CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1
CHEMBL397753 ada2c_human Human No 6.1 EC50 = 741.3 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
311 5 1 5 3.0 C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL397753 ada2c_human Human No 6.1 EC50 = 741.3 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
311 5 1 5 3.0 C[C@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL305928 ada2c_human Human Yes 7.1 EC50 = 77.6 nM Funct
Agonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphateAgonistic activity towards human Alpha-2C adrenergic receptor was measured as ability to inhibit forskolin-stimulated synthesis of cyclic adenosine monophosphate
182 1 1 3 1.7 C1CCCC(NC2=NCCO2)CC1
CHEMBL523048 ada2c_human Human No 6.1 EC50 = 776.3 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
328 5 1 3 4.5 c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1
CHEMBL1956203 ada2c_human Human No 7.1 EC50 = 79.4 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
342 5 1 3 4.8 CC(Oc1c(-c2ccccc2)cccc1-c1ccccc1)C1=NCCN1
CHEMBL1437 ada2c_human Human Yes 6.1 EC50 = 794.3 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O
CHEMBL1437 ada2c_human Human Yes 6.1 EC50 = 794.3 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O
CHEMBL1956193 ada2c_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
258 3 1 3 2.5 CC(Oc1ccccc1C(F)(F)F)C1=NCCN1
CHEMBL1437 ada2c_human Human Yes 6.1 EC50 = 794.3 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O
CHEMBL493272 ada2c_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidificationAgonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as stimulation of extracellular acidification
280 2 1 4 2.5 c1ccc(-c2cccc3c2OCC(C2=NCCN2)O3)cc1
CHEMBL70634 ada2c_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
287 4 2 5 1.2 CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1
CHEMBL1437 ada2c_human Human Yes 6.1 EC50 = 794.3 nM Funct
Agonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulationAgonistic potency at human adrenergic Alpha-2C receptor expressed in CHO cells assessed as forskolin-induced cAMP accumulation
169 2 4 4 0.1 NC[C@@H](c1ccc(c(c1)O)O)O
CHEMBL844 ada2c_human Human Yes 8.1 EC50 = 8 nM Funct
Agonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassayAgonist activity at human recombinant alpha-2C receptor expressed in PC12 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation measured after 10 mins by cAMP enzyme immunoassay
291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1
CHEMBL72441 ada2c_human Human No 8.1 EC50 = 8.9 nM Funct
Agonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptorAgonist potency at Alpha-2C adrenergic receptor assayed in CHO cells expressing human Alpha-2C adrenergic receptor
235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1
CHEMBL426900 ada2c_human Human No 6.1 EC50 = 831.8 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
280 4 1 3 3.4 Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1
CHEMBL72147 ada2c_human Human No 6.1 EC50 = 831.8 nM Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
305 1 2 5 2.1 Cc1cnc2c(Br)c(NC3=NCCN3)ccc2n1
CHEMBL72995 ada2c_human Human No 6.1 EC50 = 831.8 nM Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
305 1 2 5 2.2 CC1CN=C(Nc2ccc3nccnc3c2Br)N1
CHEMBL844 ada2c_human Human Yes 8.0 EC50 = 9.6 nM Funct
Alpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesisAlpha-2C adrenergic receptor agonistic potency as inhibition of forskolin-stimulated cyclic adenosine monophosphate synthesis
291 1 2 5 1.8 Brc1c(ccc2c1nccn2)NC1=NCCN1
CHEMBL385310 ada2c_human Human No 7.0 EC50 = 93.3 nM Funct
Agonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometryAgonist activity at human Alpha-2C adrenoceptor expressed in CHO cells assessed as induction of extracellular acidification by microphysiometry
272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL130884 ada2c_human Human No 7.0 EC50 = 93.3 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
265 4 2 3 3.2 CC(Nc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL385310 ada2c_human Human No 7.0 EC50 = 93.3 nM Funct
Agonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometryAgonist activity at human adrenergic alpha-2C receptor expressed in CHO cells assessed as extracellular acidification by cytosensor microphysiometry
272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL2431279 ada2c_human Human Yes 7.0 EC50 = 97.7 nM Bind
Agonist activity at human alpha2C ARAgonist activity at human alpha2C AR
254 3 1 3 1.8 Brc1ccccc1OCC1=NCCN1
CHEMBL1956199 ada2c_human Human Yes 5.0 EC50 = 9772.4 nM Funct
Agonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysisAgonist activity at human adrenoceptor aplha 2C expressed in CHO cells assessed as rate of extracellular acidification by cytosensor microphysiometric analysis
220 4 1 4 1.5 COc1ccccc1OC(C)C1=NCCN1
CHEMBL162682 ada2c_human Human No 9.2 IC50 = 0.6 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
485 3 0 5 4.0 Cc1nc2ccc(I)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL165350 ada2c_human Human No 9.2 IC50 = 0.7 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
437 3 0 5 4.1 Cc1nc2ccc(Br)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL162490 ada2c_human Human No 9.2 IC50 = 0.7 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
389 4 0 6 3.4 COc1cccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc12
CHEMBL351483 ada2c_human Human No 9.1 IC50 = 0.7 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
393 3 0 5 4.0 Cc1nc2ccc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL162232 ada2c_human Human No 9.1 IC50 = 0.9 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
387 3 0 5 4.0 Cc1cc(C)n2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1
CHEMBL163190 ada2c_human Human No 9.0 IC50 = 1.1 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 5 3.7 Cc1nc2cccc(C)n2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL165796 ada2c_human Human No 8.9 IC50 = 1.2 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 5 3.7 Cc1ccn2c(=O)c(CCN3CCc4oc5ccccc5c4C3)c(C)nc2c1
CHEMBL162370 ada2c_human Human No 8.9 IC50 = 1.3 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 5 3.7 Cc1ccc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2c1
CHEMBL351200 ada2c_human Human No 8.9 IC50 = 1.3 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 3 0 5 3.7 Cc1nc2c(C)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL163247 ada2c_human Human No 8.9 IC50 = 1.3 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
427 3 0 5 4.7 Cc1nc2c(Cl)cc(Cl)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL162826 ada2c_human Human No 8.8 IC50 = 1.6 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
375 3 1 6 3.1 Cc1nc2c(O)cccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL162501 ada2c_human Human Yes 8.8 IC50 = 1.7 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
359 3 0 5 3.4 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL1732 ada2c_human Human Yes 8.0 IC50 = 10 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O
CHEMBL219916 ada2c_human Human Yes 6.0 IC50 = 1011 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2
CHEMBL1628227 ada2c_human Human Yes 6.0 IC50 = 1029 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21
CHEMBL515170 ada2c_human Human No 5.0 IC50 = 10400 nM Bind
Inhibition of adrenergic Alpha-2C receptorInhibition of adrenergic Alpha-2C receptor
361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O
CHEMBL597 ada2c_human Human Yes 7.0 IC50 = 110 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1
CHEMBL2203713 ada2c_human Human No 5.0 IC50 = 11000 nM Bind
Inhibition of alpha2C adrenergic receptorInhibition of alpha2C adrenergic receptor
326 3 3 4 3.3 N=C(Nc1ccc2c(c1)CCN2C1CCNCC1)c1cccs1
CHEMBL1331786 ada2c_human Human Yes 6.0 IC50 = 1106 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N
CHEMBL420 ada2c_human Human Yes 6.0 IC50 = 1106 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N
CHEMBL84931 ada2c_human Human No 5.9 IC50 = 1174.9 nM Bind
Binding affinity for human cloned Alpha-2C adrenergic receptorBinding affinity for human cloned Alpha-2C adrenergic receptor
312 2 0 3 3.5 CN(C)CC1CC2c3ccccc3Cc3ccc(F)cc3N2O1
CHEMBL1717 ada2c_human Human Yes 5.9 IC50 = 1175 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1
CHEMBL833 ada2c_human Human Yes 5.9 IC50 = 1175 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1
CHEMBL442 ada2c_human Human Yes 7.9 IC50 = 12 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O
CHEMBL516 ada2c_human Human Yes 5.9 IC50 = 1275 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1
CHEMBL165181 ada2c_human Human No 7.9 IC50 = 14.1 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
375 3 0 5 3.8 Cc1nc2ccccn2c(=O)c1CCN1CCc2sc3ccccc3c2C1
CHEMBL133455 ada2c_human Human Yes 4.9 IC50 = 14000 nM Bind
Inhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligandInhibitory concentration required against Alpha-2A adrenergic receptor using [3H]clonidine radioligand
230 2 2 2 2.4 C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N
CHEMBL531 ada2c_human Human Yes 5.9 IC50 = 1410 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3
CHEMBL1200710 ada2c_human Human Yes 5.9 IC50 = 1413 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 4 0 2 4.5 CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
CHEMBL415 ada2c_human Human Yes 5.9 IC50 = 1413 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 4 0 2 4.5 CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
CHEMBL195437 ada2c_human Human Yes 4.9 IC50 = 14234 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1
CHEMBL954 ada2c_human Human Yes 5.8 IC50 = 1482 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1
CHEMBL305906 ada2c_human Human Yes 5.8 IC50 = 1497 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1
CHEMBL334255 ada2c_human Human Yes 5.8 IC50 = 1497 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1
CHEMBL411 ada2c_human Human Yes 4.8 IC50 = 15151 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1
CHEMBL726 ada2c_human Human Yes 6.8 IC50 = 154 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F
CHEMBL10347 ada2c_human Human Yes 7.8 IC50 = 16 nM Funct
Antagonist activity at human recombinant alpha2C adrenoceptor assessed as inhibition of epinephrine-induced cAMP accumulationAntagonist activity at human recombinant alpha2C adrenoceptor assessed as inhibition of epinephrine-induced cAMP accumulation
354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL4634827 ada2c_human Human No 4.8 IC50 = 16000 nM Bind
Inhibition of adrenergic receptor alpha2c (unknown origin)Inhibition of adrenergic receptor alpha2c (unknown origin)
302 4 2 3 2.8 CO[C@H]1CCN(Cc2c(C)cc(C)c3[nH]ccc23)[C@H](CO)C1
CHEMBL1909065 ada2c_human Human Yes 5.8 IC50 = 1610 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC
CHEMBL508112 ada2c_human Human Yes 5.8 IC50 = 1658 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
332 3 0 6 5.7 c1ccc2sc(SSc3nc4ccccc4s3)nc2c1
CHEMBL1385840 ada2c_human Human Yes 7.8 IC50 = 17 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12
CHEMBL479 ada2c_human Human Yes 6.8 IC50 = 171 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1
CHEMBL1108 ada2c_human Human Yes 5.8 IC50 = 1763 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1
CHEMBL6437 ada2c_human Human Yes 6.8 IC50 = 179 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
CHEMBL4636550 ada2c_human Human No 6.8 IC50 = 180 nM Bind
Inhibition of adrenergic receptor alpha2c (unknown origin)Inhibition of adrenergic receptor alpha2c (unknown origin)
303 1 2 3 3.3 Cc1cc(Br)c(NC2=NCCN2)c2ccccc12
CHEMBL1491 ada2c_human Human Yes 5.8 IC50 = 1800 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
CHEMBL493439 ada2c_human Human Yes 6.7 IC50 = 182 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
480 7 1 6 4.9 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21
CHEMBL50588 ada2c_human Human Yes 6.7 IC50 = 182 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
480 7 1 6 4.9 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21
CHEMBL54 ada2c_human Human Yes 5.7 IC50 = 1845 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl
CHEMBL83658 ada2c_human Human No 5.7 IC50 = 1862.1 nM Bind
Binding affinity for human cloned Alpha-2C adrenergic receptorBinding affinity for human cloned Alpha-2C adrenergic receptor
294 2 0 3 3.4 CN(C)CC1CC2c3ccccc3Cc3ccccc3N2O1
CHEMBL459265 ada2c_human Human Yes 5.7 IC50 = 1884 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1
CHEMBL64894 ada2c_human Human Yes 5.7 IC50 = 1884 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1
CHEMBL19215 ada2c_human Human Yes 6.7 IC50 = 189 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C
CHEMBL621 ada2c_human Human Yes 5.7 IC50 = 1942 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
CHEMBL296419 ada2c_human Human Yes 5.7 IC50 = 1959 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2
CHEMBL1182210 ada2c_human Human Yes 5.7 IC50 = 1961 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1
CHEMBL221753 ada2c_human Human Yes 5.7 IC50 = 1961 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1
CHEMBL654 ada2c_human Human Yes 6.7 IC50 = 199.5 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1
CHEMBL164612 ada2c_human Human No 8.7 IC50 = 2.2 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
393 3 0 5 4.0 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3c(Cl)cccc3c2C1
CHEMBL162436 ada2c_human Human No 8.6 IC50 = 2.7 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
435 5 0 5 4.6 O=c1c(CCN2CCc3oc4ccccc4c3C2)c(Cc2ccccc2)nc2ccccn12
CHEMBL1201156 ada2c_human Human Yes 6.7 IC50 = 203 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2ccccc21
CHEMBL445 ada2c_human Human Yes 6.7 IC50 = 203 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2ccccc21
CHEMBL584554 ada2c_human Human No 6.7 IC50 = 215 nM Bind
Inhibition of adrenergic Alpha-2C receptorInhibition of adrenergic Alpha-2C receptor
428 4 2 2 4.5 CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1
CHEMBL30008 ada2c_human Human Yes 6.7 IC50 = 222 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 6 0 2 5.4 Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1
CHEMBL539027 ada2c_human Human Yes 6.7 IC50 = 222 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 6 0 2 5.4 Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1
CHEMBL552659 ada2c_human Human Yes 6.7 IC50 = 222 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 6 0 2 5.4 Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1
CHEMBL1479 ada2c_human Human Yes 4.6 IC50 = 23752 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL643 ada2c_human Human Yes 5.6 IC50 = 2431 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
284 3 0 3 4.2 CN(C(CN1c2ccccc2Sc2c1cccc2)C)C
CHEMBL679 ada2c_human Human Yes 5.6 IC50 = 2449 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
183 3 4 4 0.4 CNC[C@@H](c1ccc(c(c1)O)O)O
CHEMBL282575 ada2c_human Human Yes 4.6 IC50 = 24650 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
376 2 1 3 5.1 C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O
CHEMBL564 ada2c_human Human Yes 6.6 IC50 = 253 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
284 4 0 3 4.2 CN(CCCN1c2ccccc2Sc2c1cccc2)C
CHEMBL762 ada2c_human Human Yes 5.6 IC50 = 2633 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C
CHEMBL15245 ada2c_human Human Yes 7.6 IC50 = 27.1 nM Bind
Displacement of radioligand from human adrenergic Alpha-2C receptor after 60 minsDisplacement of radioligand from human adrenergic Alpha-2C receptor after 60 mins
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL165677 ada2c_human Human No 7.6 IC50 = 27.5 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
393 3 0 5 4.0 Cc1nc2ccccn2c(=O)c1CCN1CCc2oc3ccc(Cl)cc3c2C1
CHEMBL305660 ada2c_human Human Yes 6.6 IC50 = 275.7 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1
CHEMBL12089 ada2c_human Human Yes 5.6 IC50 = 2837 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2
CHEMBL295124 ada2c_human Human Yes 5.6 IC50 = 2837 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
336 2 0 4 3.1 COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2
CHEMBL162147 ada2c_human Human No 8.4 IC50 = 3.6 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
461 3 0 5 5.0 Cc1nc2c(Cl)cc(C(F)(F)F)cn2c(=O)c1CCN1CCc2oc3ccccc3c2C1
CHEMBL21731 ada2c_human Human Yes 5.5 IC50 = 3044 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
277 4 1 1 4.2 CNCCCC12CCC(c3ccccc31)c1ccccc12
CHEMBL1221512 ada2c_human Human Yes 5.5 IC50 = 3136 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS
CHEMBL481 ada2c_human Human Yes 5.5 IC50 = 3171 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
586 4 1 9 4.1 CCc1c2c(nc3ccc(OC(=O)N4CCC(N5CCCCC5)CC4)cc13)-c1cc3c(c(=O)n1C2)COC(=O)[C@]3(O)CC
CHEMBL1113 ada2c_human Human Yes 5.5 IC50 = 3174 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
313 0 1 4 3.4 Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1
CHEMBL588119 ada2c_human Human Yes 5.5 IC50 = 3446 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
337 12 2 3 5.6 CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1
CHEMBL15245 ada2c_human Human Yes 7.4 IC50 = 36 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL71 ada2c_human Human Yes 6.4 IC50 = 374 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C
CHEMBL17157 ada2c_human Human Yes 5.4 IC50 = 3748 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O
CHEMBL1403281 ada2c_human Human Yes 7.4 IC50 = 38 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
575 5 3 6 2.4 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C
CHEMBL546257 ada2c_human Human Yes 5.4 IC50 = 3857 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
CHEMBL554190 ada2c_human Human Yes 5.4 IC50 = 3857 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
CHEMBL7568 ada2c_human Human Yes 5.4 IC50 = 3857 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
399 9 1 4 6.0 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
CHEMBL1200633 ada2c_human Human Yes 5.4 IC50 = 3920.9 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
None None None CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O
CHEMBL1201203 ada2c_human Human Yes 6.4 IC50 = 395 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1
CHEMBL438151 ada2c_human Human Yes 6.4 IC50 = 395 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
307 4 0 2 4.4 CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1
CHEMBL157138 ada2c_human Human Yes 8.4 IC50 = 4.3 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
CHEMBL1289 ada2c_human Human Yes 5.4 IC50 = 4045 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl
CHEMBL1262 ada2c_human Human Yes 5.4 IC50 = 4164.5 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1
CHEMBL1306 ada2c_human Human Yes 6.4 IC50 = 418 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
531 8 0 8 4.5 CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1
CHEMBL6437 ada2c_human Human Yes 7.4 IC50 = 42.7 nM Bind
Binding affinity for human cloned Alpha-2C adrenergic receptorBinding affinity for human cloned Alpha-2C adrenergic receptor
264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
CHEMBL716 ada2c_human Human Yes 6.4 IC50 = 420.8 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2
CHEMBL290106 ada2c_human Human Yes 5.4 IC50 = 4392 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O
CHEMBL1709 ada2c_human Human Yes 5.4 IC50 = 4477 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21
CHEMBL809 ada2c_human Human Yes 5.4 IC50 = 4477 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
305 2 1 1 5.2 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21
CHEMBL1909072 ada2c_human Human Yes 7.4 IC50 = 45 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
401 5 1 4 4.5 NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
CHEMBL1200348 ada2c_human Human Yes 5.3 IC50 = 4934 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
CHEMBL1221 ada2c_human Human Yes 5.3 IC50 = 4934 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1
CHEMBL508338 ada2c_human Human No 5.3 IC50 = 5041 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
None None None None
CHEMBL493 ada2c_human Human Yes 6.3 IC50 = 520 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
653 5 3 6 3.2 CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C
CHEMBL787 ada2c_human Human Yes 5.3 IC50 = 5279 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1
CHEMBL10316 ada2c_human Human Yes 7.3 IC50 = 53.7 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL543467 ada2c_human Human Yes 7.3 IC50 = 53.7 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL715 ada2c_human Human Yes 6.3 IC50 = 531 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C
CHEMBL1381098 ada2c_human Human Yes 4.3 IC50 = 54539 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
185 1 0 2 3.6 S=C=Nc1cccc2ccccc12
CHEMBL162058 ada2c_human Human No 7.2 IC50 = 57.5 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
419 5 0 7 3.4 COc1cc2nc(C)c(CCN3CCc4oc5ccccc5c4C3)c(=O)n2cc1OC
CHEMBL629 ada2c_human Human Yes 7.2 IC50 = 59 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
277 3 0 1 4.2 CN(CCC=C1c2ccccc2CCc2c1cccc2)C
CHEMBL165776 ada2c_human Human No 8.2 IC50 = 6.6 nM Bind
Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.Binding affinity at human Alpha-2C adrenergic receptor in CHO cells by [3H]rauwolscine (1 nM) displacement.
373 4 0 5 3.7 Cc1nc2ccccn2c(=O)c1CCCN1CCc2oc3ccccc3c2C1
CHEMBL611 ada2c_human Human Yes 5.2 IC50 = 6042 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1
CHEMBL862 ada2c_human Human Yes 5.2 IC50 = 6447 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
245 2 2 1 1.3 O=C(Cc1c(Cl)cccc1Cl)N=C(N)N
CHEMBL2 ada2c_human Human Yes 6.2 IC50 = 647 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
CHEMBL43064 ada2c_human Human Yes 6.2 IC50 = 652 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
368 6 0 2 5.1 C(=C/c1ccccc1)\CN1CCN(C(c2ccccc2)c2ccccc2)CC1
CHEMBL496 ada2c_human Human Yes 5.2 IC50 = 6975.4 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl
CHEMBL42 ada2c_human Human Yes 8.1 IC50 = 7.9 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL12131 ada2c_human Human Yes 5.2 IC50 = 7100 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
662 4 2 3 7.1 Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O
CHEMBL81 ada2c_human Human Yes 6.1 IC50 = 738 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O
CHEMBL470432 ada2c_human Human No 6.1 IC50 = 741.3 nM Bind
Displacement of [3H]RX821002 form human recombinant Alpha-2C adrenergic receptorDisplacement of [3H]RX821002 form human recombinant Alpha-2C adrenergic receptor
343 5 0 5 4.4 CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1
CHEMBL1729 ada2c_human Human Yes 6.1 IC50 = 780 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N
CHEMBL560739 ada2c_human Human Yes 6.1 IC50 = 780 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N
CHEMBL1630578 ada2c_human Human Yes 5.1 IC50 = 7898 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
624 6 0 8 5.5 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1
CHEMBL1255837 ada2c_human Human Yes 8.1 IC50 = 8.7 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O
CHEMBL601773 ada2c_human Human Yes 8.1 IC50 = 8.7 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O
CHEMBL728 ada2c_human Human Yes 7.1 IC50 = 82 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
CHEMBL315772 ada2c_human Human No 6.1 IC50 = 871.0 nM Bind
Binding affinity for human cloned Alpha-2C adrenergic receptorBinding affinity for human cloned Alpha-2C adrenergic receptor
328 2 0 3 4.1 CN(C)CC1CC2c3ccccc3Cc3ccc(Cl)cc3N2O1
CHEMBL85 ada2c_human Human Yes 8.0 IC50 = 9.6 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL723 ada2c_human Human Yes 7.1 IC50 = 90 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O
CHEMBL1626 ada2c_human Human Yes 7.0 IC50 = 95 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C
CHEMBL435352 ada2c_human Human No 10.5 Ki = 0.0 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
477 9 0 7 3.5 COCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1
CHEMBL176261 ada2c_human Human No 10.0 Ki = 0.1 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
490 9 0 7 3.5 C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OCCN(C)C)cc4OC[C@H]32)CC1
CHEMBL180470 ada2c_human Human No 10.0 Ki = 0.1 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
419 5 1 6 3.2 C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(O)cc4OC[C@H]32)CC1
CHEMBL2112985 ada2c_human Human No 10.0 Ki = 0.1 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CN2
CHEMBL390718 ada2c_human Human No 10.0 Ki = 0.1 nM Bind
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2
CHEMBL91157 ada2c_human Human No 10.0 Ki = 0.1 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2
CHEMBL91157 ada2c_human Human No 10.0 Ki = 0.1 nM Bind
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2
CHEMBL1256414 ada2c_human Human No 9.9 Ki = 0.1 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21
CHEMBL1255723 ada2c_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 2 1 1 3.0 CC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1
CHEMBL1256414 ada2c_human Human No 9.8 Ki = 0.2 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21
CHEMBL175853 ada2c_human Human No 9.7 Ki = 0.2 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
491 8 0 8 3.1 COCC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1
CHEMBL176002 ada2c_human Human No 9.7 Ki = 0.2 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
433 6 0 6 3.5 COc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1
CHEMBL176116 ada2c_human Human No 9.7 Ki = 0.2 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
461 6 0 7 3.4 CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1
CHEMBL179237 ada2c_human Human No 9.7 Ki = 0.2 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
535 13 0 8 4.0 CCOCCOCCOc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1
CHEMBL91157 ada2c_human Human No 9.7 Ki = 0.2 nM Funct
Binding affinity for alpha-2C-adrenergic receptorBinding affinity for alpha-2C-adrenergic receptor
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2
CHEMBL100879 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
469 7 0 8 3.6 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4cccs4)CC3)[C@@H]1CO2
CHEMBL101596 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
469 7 0 8 3.6 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccsc4)CC3)[C@@H]1CO2
CHEMBL263424 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4)CC3)[C@@H]1CO2
CHEMBL319119 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
499 7 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cc(F)ccc4F)CC3)[C@@H]1CO2
CHEMBL419316 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2
CHEMBL91157 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2
CHEMBL98646 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
469 7 0 8 3.6 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccs4)CC3)[C@@H]1CO2
CHEMBL419316 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2
CHEMBL93171 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CO2
CHEMBL419316 ada2c_human Human No 9.7 Ki = 0.2 nM Bind
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2
CHEMBL1256414 ada2c_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
196 1 1 1 2.4 c1ccc2c(c1)C[C@]1(c3c[nH]cn3)C[C@H]21
CHEMBL318235 ada2c_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2
CHEMBL1256378 ada2c_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.6 C[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1
CHEMBL175911 ada2c_human Human No 9.5 Ki = 0.3 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
487 7 0 7 3.8 C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C5CC5)cc4OC[C@H]32)CC1
CHEMBL328195 ada2c_human Human No 9.5 Ki = 0.3 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
469 7 0 8 3.6 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccsc4)CC3)[C@@H]1CO2
CHEMBL98541 ada2c_human Human No 9.5 Ki = 0.3 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4)CC3)[C@@H]1CO2
CHEMBL319530 ada2c_human Human No 9.4 Ki = 0.4 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
453 7 0 8 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccco4)CC3)[C@@H]1CO2
CHEMBL99868 ada2c_human Human No 9.4 Ki = 0.4 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
493 8 0 8 3.5 COc1ccccc1/C=C(\C)CN1CCN(C[C@@H]2ON=C3c4cc(OC)c(OC)cc4OC[C@H]32)CC1
CHEMBL1255724 ada2c_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
238 3 1 1 3.4 CCC[C@H]1[C@@H]2c3ccccc3C[C@]12c1c[nH]cn1
CHEMBL477608 ada2c_human Human No 9.3 Ki = 0.5 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
467 7 2 7 2.9 CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1
CHEMBL180322 ada2c_human Human No 9.3 Ki = 0.5 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
473 7 0 7 3.6 C=CC(=O)Oc1ccc2c(c1)OC[C@@H]1C2=NO[C@H]1CN1CCN(C/C(C)=C/c2ccccc2)CC1
CHEMBL369378 ada2c_human Human No 9.3 Ki = 0.5 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
487 7 0 6 4.8 C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC5CCCC5)cc4OC[C@H]32)CC1
CHEMBL425324 ada2c_human Human No 9.3 Ki = 0.5 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
524 7 0 8 4.1 C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)c5ccncc5)cc4OC[C@H]32)CC1
CHEMBL15245 ada2c_human Human Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cellsDisplacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cells
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL15245 ada2c_human Human Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cells
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL99916 ada2c_human Human No 9.3 Ki = 0.5 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
453 7 0 8 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccco4)CC3)[C@@H]1CO2
CHEMBL328114 ada2c_human Human No 9.3 Ki = 0.5 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2
CHEMBL328114 ada2c_human Human No 9.3 Ki = 0.5 nM Bind
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
449 7 0 7 3.1 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4)CC3)[C@@H]1CO2
CHEMBL1256609 ada2c_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 3.0 C[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1
CHEMBL476569 ada2c_human Human No 9.2 Ki = 0.6 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
468 10 1 7 2.8 CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1
CHEMBL419316 ada2c_human Human No 9.2 Ki = 0.6 nM Funct
Binding affinity for alpha-2C-adrenergic receptorBinding affinity for alpha-2C-adrenergic receptor
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2
CHEMBL329065 ada2c_human Human No 9.2 Ki = 0.6 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
479 7 1 8 3.2 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(O)cc4)CC3)[C@@H]1CO2
CHEMBL327875 ada2c_human Human No 9.2 Ki = 0.6 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C(\C)c4ccccc4)CC3)C1CO2
CHEMBL157138 ada2c_human Human Yes 9.2 Ki = 0.6 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
338 3 2 2 2.8 CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
CHEMBL196451 ada2c_human Human No 9.2 Ki = 0.7 nM Bind
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
515 7 3 5 4.1 O=C(CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1
CHEMBL318235 ada2c_human Human No 9.2 Ki = 0.7 nM Bind
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2
CHEMBL318235 ada2c_human Human No 9.2 Ki = 0.7 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2
CHEMBL419336 ada2c_human Human No 9.2 Ki = 0.7 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
499 7 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccc(F)c4F)CC3)[C@@H]1CO2
CHEMBL95218 ada2c_human Human No 9.2 Ki = 0.7 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4cccc(F)c4)CC3)[C@@H]1CO2
CHEMBL10332 ada2c_human Human Yes 9.1 Ki = 0.8 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
234 2 1 5 0.8 COC1(COc2c(O1)cccc2)C1=NCCN1
CHEMBL25554 ada2c_human Human Yes 9.1 Ki = 0.8 nM Bind
Binding affinity against Alpha-2C adrenergic receptor from human clones.Binding affinity against Alpha-2C adrenergic receptor from human clones.
345 8 1 6 2.5 COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC
CHEMBL514837 ada2c_human Human No 9.1 Ki = 0.8 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
468 10 1 7 2.8 CCCCOc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1
CHEMBL515331 ada2c_human Human No 9.1 Ki = 0.8 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
513 8 1 8 3.3 N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1
CHEMBL394218 ada2c_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
505 7 1 7 3.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)NC4CN5CCC4CC5)cc13)CC2
CHEMBL15245 ada2c_human Human Yes 9.1 Ki = 0.8 nM Bind
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2C receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2C receptor expressed in CHO cell membranes incubated for 60 mins
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL328631 ada2c_human Human No 9.1 Ki = 0.8 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
499 7 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccc(F)cc4F)CC3)[C@@H]1CO2
CHEMBL92860 ada2c_human Human No 9.1 Ki = 0.8 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2
CHEMBL92860 ada2c_human Human No 9.1 Ki = 0.8 nM Bind
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2
CHEMBL15245 ada2c_human Human Yes 9.1 Ki = 0.9 nM Bind
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL524153 ada2c_human Human No 9.1 Ki = 0.9 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
488 8 1 7 3.5 O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1
CHEMBL101361 ada2c_human Human No 9.1 Ki = 0.9 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
493 8 0 8 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4OC)CC3)[C@@H]1CO2
CHEMBL390718 ada2c_human Human No 9.0 Ki = 0.9 nM Bind
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C(C)=C/c4ccccc4)CC3)C1CN2
CHEMBL762 ada2c_human Human Yes 9.0 Ki = 1 nM Bind
Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)
260 2 2 3 2.9 Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C
CHEMBL10347 ada2c_human Human Yes 9.0 Ki = 1 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL369938 ada2c_human Human No 9.0 Ki = 1.1 nM Bind
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
530 7 4 5 3.9 O=C(NCCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O)OCc1ccccc1
CHEMBL42 ada2c_human Human Yes 8.9 Ki = 1.1 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL1255770 ada2c_human Human No 8.9 Ki = 1.2 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 1 1 1 3.0 CC1(C)[C@@H]2c3ccccc3C[C@@]21c1c[nH]cn1
CHEMBL1255837 ada2c_human Human Yes 8.9 Ki = 1.3 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O
CHEMBL601773 ada2c_human Human Yes 8.9 Ki = 1.3 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
611 5 3 6 2.7 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O
CHEMBL1256610 ada2c_human Human No 8.9 Ki = 1.3 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
224 2 1 1 3.3 CC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1
CHEMBL85 ada2c_human Human Yes 8.9 Ki = 1.4 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL1203852 ada2c_rat Rat Yes 8.9 Ki = 1.4 nM Bind
In vitro binding affinity against alpha-2C adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2C adrenergic receptor of male Wistar rat
242 2 1 2 2.8 Brc1csc(Cc2c[nH]cn2)c1
CHEMBL354272 ada2c_rat Rat Yes 8.9 Ki = 1.4 nM Bind
In vitro binding affinity against alpha-2C adrenergic receptor of male Wistar ratIn vitro binding affinity against alpha-2C adrenergic receptor of male Wistar rat
242 2 1 2 2.8 Brc1csc(Cc2c[nH]cn2)c1
CHEMBL91157 ada2c_human Human No 8.9 Ki = 1.4 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccccc4)CC3)[C@@H]1CO2
CHEMBL1255616 ada2c_human Human No 8.8 Ki = 1.5 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
238 3 1 1 3.7 CCC[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1
CHEMBL1732 ada2c_human Human Yes 8.8 Ki = 1.5 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
583 4 3 6 2.1 CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O
CHEMBL1256566 ada2c_human Human No 8.8 Ki = 1.5 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
254 4 1 2 3.3 CCCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1
CHEMBL178588 ada2c_human Human No 8.8 Ki = 1.6 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
503 6 0 7 4.5 C/C(=C\c1ccccc1)CN1CCN(C[C@@H]2ON=C3c4ccc(OC(=O)C(C)(C)C)cc4OC[C@H]32)CC1
CHEMBL2112969 ada2c_human Human No 8.8 Ki = 1.6 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
470 8 1 8 2.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(CCOc4ccc(F)cc4)CC3)[C@@H]1CN2
CHEMBL491420 ada2c_human Human No 8.8 Ki = 1.7 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
499 7 0 9 4.3 c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1
CHEMBL2112978 ada2c_human Human No 8.8 Ki = 1.7 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
389 5 0 5 3.1 C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4OC[C@H]32)CC1
CHEMBL90943 ada2c_human Human No 8.8 Ki = 1.7 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
389 5 0 5 3.1 C(=C/c1ccccc1)\CN1CCN(CC2ON=C3c4ccccc4OCC32)CC1
CHEMBL442 ada2c_human Human Yes 8.7 Ki = 1.8 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
581 4 3 6 2.0 O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O
CHEMBL515331 ada2c_human Human No 8.7 Ki = 1.9 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
513 8 1 8 3.3 N#Cc1cccc(Oc2ncccc2C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)c1
CHEMBL524153 ada2c_human Human No 8.7 Ki = 1.9 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
488 8 1 7 3.5 O=C(NCCN1CCCN(C[C@H]2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1
CHEMBL491420 ada2c_human Human No 8.7 Ki = 1.9 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
499 7 0 9 4.3 c1ccc(Oc2ncccc2-c2noc(CN3CCCN(CC4COc5ccccc5O4)CC3)n2)cc1
CHEMBL15245 ada2c_human Human Yes 8.7 Ki = 1.9 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL3290012 ada2c_human Human No 8.7 Ki = 1.9 nM Bind
Displacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cells
487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1
CHEMBL90247 ada2c_human Human No 8.7 Ki = 1.9 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
419 6 0 6 3.1 COc1ccc2c(c1)OCC1C2=NOC1CN1CCN(C/C=C/c2ccccc2)CC1
CHEMBL90419 ada2c_human Human No 8.7 Ki = 1.9 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
451 8 0 7 3.1 COc1cc2c(cc1OC)C1=NOC(CN3CCN(CCCc4ccccc4)CC3)C1CO2
CHEMBL1256503 ada2c_human Human No 8.7 Ki = 2.0 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1
CHEMBL85 ada2c_human Human Yes 8.0 Ki = 10 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL318235 ada2c_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
481 7 0 7 3.7 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4ccc(F)cc4)CC3)[C@@H]1CO2
CHEMBL101411 ada2c_human Human No 8.0 Ki = 10 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
483 7 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(Cl)cc4)CC3)[C@@H]1CO2
CHEMBL419316 ada2c_human Human No 8.0 Ki = 10 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
463 7 0 7 3.5 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CO2
CHEMBL1256565 ada2c_human Human No 8.0 Ki = 10.2 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
240 3 1 2 2.9 CCO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1
CHEMBL191703 ada2c_human Human Yes 8.0 Ki = 10.5 nM Bind
Displacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cells
356 1 0 2 4.8 CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C
CHEMBL191703 ada2c_human Human Yes 8.0 Ki = 10.6 nM Bind
Displacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cellsDisplacement of [3H]rauwolscine from human adrenergic alpha 2C4 receptor expressed in mouse LTK- cells
356 1 0 2 4.8 CN([C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]24[C@H]3CC[C@@H]4[C@@H](N(C2)C)C)C1)C)C
CHEMBL47313 ada2c_human Human No 8.0 Ki = 10.7 nM Bind
Inhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
272 4 1 3 3.2 c1ccc(CC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1
CHEMBL1112 ada2c_human Human Yes 7.0 Ki = 100 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl
CHEMBL42 ada2c_human Human Yes 7.0 Ki = 100 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL715 ada2c_human Human Yes 7.0 Ki = 100 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C
CHEMBL716 ada2c_human Human Yes 7.0 Ki = 100 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2
CHEMBL440594 ada2c_human Human No 7.0 Ki = 100 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
360 6 2 4 5.1 Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C
CHEMBL1435188 ada2c_human Human No 7.0 Ki = 100 nM Bind
Bnding affinity against cloned human Alpha-2C adrenergic receptor was evaluatedBnding affinity against cloned human Alpha-2C adrenergic receptor was evaluated
471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1
CHEMBL299879 ada2c_human Human No 7.0 Ki = 100 nM Bind
Bnding affinity against cloned human Alpha-2C adrenergic receptor was evaluatedBnding affinity against cloned human Alpha-2C adrenergic receptor was evaluated
471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1
CHEMBL440594 ada2c_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
360 6 2 4 5.1 Cc1nc2ccccc2c(Nc2ccc(NCCN3CCCC3)cc2)c1C
CHEMBL314960 ada2c_human Human No 6.0 Ki = 1000 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
597 9 2 5 7.2 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)cc1
CHEMBL12131 ada2c_human Human Yes 6.0 Ki = 1000 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
662 4 2 3 7.1 Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O
CHEMBL4457754 ada2c_human Human No 6.0 Ki = 1000 nM Bind
Displacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human recombinant adrenergic Alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method
264 1 1 2 3.7 C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2
CHEMBL76 ada2c_human Human Yes 5.0 Ki = 10000 nM Bind
Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine
319 8 1 3 4.8 CCN(CCCC(Nc1ccnc2c1ccc(c2)Cl)C)CC
CHEMBL4088272 ada2c_human Human Yes 5.0 Ki = 10000 nM Bind
Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine
282 4 0 3 4.1 CCCN1CCC=C(c2cc(-c3ccc(C)cc3)no2)C1
CHEMBL496 ada2c_human Human Yes 6.0 Ki = 1013.5 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl
CHEMBL88628 ada2c_human Human No 6.0 Ki = 1023.3 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
606 9 3 6 5.0 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc2c(c1)OCO2
CHEMBL3897499 ada2c_human Human No 6.0 Ki = 1036 nM Bind
Displacement of [3H]Rauwolscine from human Alpha2C receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]Rauwolscine from human Alpha2C receptor expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method
416 3 0 2 6.7 CCCN1CC[C@H]2c3cc4ccc(C(F)(F)F)cc4nc3[C@H](CC)[C@H]3CCC[C@@H]1[C@@H]32
CHEMBL3588908 ada2c_human Human Yes 5.0 Ki = 10471.3 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
223 4 1 4 1.1 COc1ccccc1OCC1CNCCO1
CHEMBL81 ada2c_human Human Yes 7.0 Ki = 107 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O
CHEMBL3588904 ada2c_human Human No 6.0 Ki = 1071.5 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
261 4 1 3 3.8 c1cncc(-c2ccccc2NCc2ccncc2)c1
CHEMBL426317 ada2c_human Human No 7.0 Ki = 109 nM Bind
Binding affinity to alpha 2C adrenergic receptor by radioligand binding assayBinding affinity to alpha 2C adrenergic receptor by radioligand binding assay
373 7 0 8 0.6 COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1
CHEMBL217768 ada2c_human Human No 7.0 Ki = 109.9 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
378 4 1 4 4.7 CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2
CHEMBL291166 ada2c_human Human No 6.0 Ki = 1096 nM Bind
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
524 7 1 4 4.4 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C
CHEMBL3753318 ada2c_human Human No 6.0 Ki = 1096.5 nM Bind
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay
254 7 1 1 3.7 C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12
CHEMBL426959 ada2c_human Human No 8.0 Ki = 11 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
458 7 0 5 3.9 CC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(CCC/C=C/c3ccccc3)CC2)c2ccccc21
CHEMBL393597 ada2c_human Human No 8.0 Ki = 11 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
447 6 0 5 5.8 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4F)cc13)CC2
CHEMBL3590203 ada2c_human Human No 7.9 Ki = 11.8 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
222 3 1 2 2.7 N#Cc1cccc(-c2ccccc2CCN)c1
CHEMBL217768 ada2c_human Human No 7.0 Ki = 110 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
378 4 1 4 4.7 CCc1c(C)nc2c(c1Nc1ccc(N3CCN(C)C(C)C3)cc1)CCCC2
CHEMBL1224527 ada2c_human Human No 6.0 Ki = 1100 nM Bind
Binding affinity to adrenergic Alpha-2C receptorBinding affinity to adrenergic Alpha-2C receptor
295 1 3 3 3.1 Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21
CHEMBL1022 ada2c_human Human Yes 6.0 Ki = 1100 nM Bind
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
227 2 2 2 3.5 Clc1cccc(Cl)c1Nc1ncc[nH]1
CHEMBL2112979 ada2c_human Human No 7.0 Ki = 112 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
385 5 0 4 3.8 C1=C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21
CHEMBL1278085 ada2c_human Human No 7.0 Ki = 112.2 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
282 4 2 4 2.8 C[C@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL1729 ada2c_human Human Yes 7.0 Ki = 113 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N
CHEMBL560739 ada2c_human Human Yes 7.0 Ki = 113 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N
CHEMBL72768 ada2c_human Human No 6.9 Ki = 114.8 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
239 4 2 4 2.0 CSc1ccc(F)cc1NCC1=NCCN1
CHEMBL2205827 ada2c_human Human No 5.9 Ki = 1145 nM Bind
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
325 4 1 4 2.0 COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC
CHEMBL2205827 ada2c_human Human No 5.9 Ki = 1145 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
325 4 1 4 2.0 COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC
CHEMBL1630578 ada2c_human Human Yes 5.9 Ki = 1148 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
624 6 0 8 5.5 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1
CHEMBL315538 ada2c_human Human No 5.9 Ki = 1148.2 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
593 10 2 6 6.5 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(OC)cc1
CHEMBL74342 ada2c_human Human No 4.9 Ki = 11481.5 nM Bind
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
345 1 2 5 3.1 Brc1c(NC2=N[C@@H]3CCCC[C@@H]3N2)ccc2nccnc12
CHEMBL598391 ada2c_human Human Yes 5.9 Ki = 1174.9 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
236 2 0 2 2.7 Brc1cccc(Cn2ccnc2)c1
CHEMBL2112976 ada2c_human Human No 7.9 Ki = 12 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
472 6 1 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CN2
CHEMBL728 ada2c_human Human Yes 7.9 Ki = 12 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
373 4 0 4 4.6 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2
CHEMBL75030 ada2c_human Human Yes 7.9 Ki = 12.0 nM Bind
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine
216 1 1 3 2.0 c1ccc2c(c1)CCCC2NC1=NCCO1
CHEMBL289480 ada2c_human Human Yes 7.9 Ki = 12.6 nM Bind
Displacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counterDisplacement of [3H]RX821001 from human alpha2C adrenoceptor expressed in CHO cells after 60 mins by gamma counter
180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1
CHEMBL194849 ada2c_human Human No 7.9 Ki = 12.8 nM Bind
Binding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
282 3 3 5 2.3 Cc1ccc(N(NC2=NCCN2)c2cccc(O)c2)cc1
CHEMBL49284 ada2c_human Human No 6.9 Ki = 120 nM Bind
Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells
231 1 4 5 1.2 Cc1c(NC2=NCCN2)ccc2c1NCCN2
CHEMBL3343700 ada2c_human Human No 5.9 Ki = 1200 nM Bind
Displacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation countingDisplacement of [3H]RS-79948-197 from human alpha2C adrenoceptor expressed in CHO-K1 cells after 45 mins by liquid scintillation counting
219 1 2 3 0.5 Fc1cccc2cnn(N=C3NCCN3)c12
CHEMBL296660 ada2c_human Human No 6.9 Ki = 123.0 nM Bind
Inhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
222 3 1 3 2.2 CCC[C@H]1C2CCC(C2)[C@H]1NC1=NCCO1
CHEMBL48341 ada2c_human Human No 6.9 Ki = 123.0 nM Bind
Inhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
298 5 1 3 3.4 c1ccc(CCC[C@H]2C3CCC(C3)[C@H]2NC2=NCCO2)cc1
CHEMBL222138 ada2c_human Human No 5.9 Ki = 1230.3 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
311 5 1 5 3.0 CC(Oc1ccccc1-c1ccccc1[N+](=O)[O-])C1=NCCN1
CHEMBL1276219 ada2c_human Human No 6.9 Ki = 125.9 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL1276219 ada2c_human Human No 6.9 Ki = 125.9 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
230 4 1 3 2.3 C[C@@H](Oc1ccccc1C1CC1)C1=NCCN1
CHEMBL1276248 ada2c_human Human No 6.9 Ki = 125.9 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
272 4 1 4 3.2 C[C@H](Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL3289656 ada2c_human Human Yes 6.9 Ki = 125.9 nM Bind
Displacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assay
339 5 0 6 2.8 c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1
CHEMBL492445 ada2c_human Human No 5.9 Ki = 1258.9 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
280 2 1 4 2.5 c1ccc(-c2ccc3c(c2)OC(C2=NCCN2)CO3)cc1
CHEMBL221989 ada2c_human Human No 5.9 Ki = 1258.9 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
267 4 1 4 2.5 CC(Oc1ccccc1-c1ccccn1)C1=NCCN1
CHEMBL3289656 ada2c_human Human Yes 6.9 Ki = 126 nM Bind
Displacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assayDisplacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assay
339 5 0 6 2.8 c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1
CHEMBL157206 ada2c_human Human No 6.9 Ki = 128.8 nM Bind
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
270 7 1 3 2.9 C=CCc1cccc(CC=C)c1OC(C)C1=NCCN1
CHEMBL723 ada2c_human Human Yes 7.9 Ki = 13 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O
CHEMBL93801 ada2c_human Human No 7.9 Ki = 13 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
479 6 0 8 3.8 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4csc5ccccc45)CC3)C1CO2
CHEMBL1255582 ada2c_human Human Yes 7.9 Ki = 13.8 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
230 2 1 1 3.0 CCC1(c2c[nH]cn2)Cc2ccc(F)cc2C1
CHEMBL420060 ada2c_human Human Yes 6.9 Ki = 131 nM Bind
Binding affinity against Alpha-2C adrenergic receptor from human clones.Binding affinity against Alpha-2C adrenergic receptor from human clones.
401 7 1 8 1.0 COc1ccccc1N1CCN(CC1)CCCNc1c(C)c(=O)n(c(=O)n1C)C
CHEMBL385310 ada2c_human Human No 6.9 Ki = 131.8 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL385310 ada2c_human Human No 6.9 Ki = 131.8 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
272 4 1 4 3.2 CC(Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL218730 ada2c_human Human No 6.9 Ki = 132 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
388 3 1 4 5.4 Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1
CHEMBL218730 ada2c_human Human No 6.9 Ki = 132.1 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
388 3 1 4 5.4 Cc1cc(C)c2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1
CHEMBL4544251 ada2c_human Human No 5.9 Ki = 1320 nM Bind
Binding affinity to human alpha2C receptor expressed in MDCK cells by PDSP assayBinding affinity to human alpha2C receptor expressed in MDCK cells by PDSP assay
464 5 2 6 5.5 O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-n2cc(-c3ccc(Cl)s3)nn2)c1
CHEMBL448620 ada2c_human Human Yes 5.9 Ki = 1320 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
608 10 2 7 5.6 COC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL217568 ada2c_human Human No 6.9 Ki = 134.9 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
394 3 1 4 5.4 Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C
CHEMBL217568 ada2c_human Human No 6.9 Ki = 135 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
394 3 1 4 5.4 Cc1nc2cccc(Cl)c2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C
CHEMBL2205824 ada2c_human Human No 5.9 Ki = 1369 nM Bind
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
295 3 1 3 2.0 COc1cccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)c1
CHEMBL3588912 ada2c_human Human No 4.9 Ki = 13803.8 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
242 2 1 3 2.6 COc1ccc(C2NCCCn3cccc32)cc1
CHEMBL1626 ada2c_human Human Yes 7.9 Ki = 14 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C
CHEMBL49395 ada2c_human Human Yes 5.9 Ki = 1412.5 nM Bind
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
213 1 2 5 1.0 c1cnc2cc(NC3=NCCN3)ccc2n1
CHEMBL210578 ada2c_human Human No 6.8 Ki = 142.8 nM Bind
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay
401 6 1 3 5.0 O=C(CCCN1C2CCC1CC(O)(c1ccc(Cl)cc1)C2)c1ccc(F)cc1
CHEMBL476839 ada2c_human Human No 6.8 Ki = 143 nM Bind
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
401 9 1 4 4.3 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1
CHEMBL117248 ada2c_human Human Yes 6.8 Ki = 144.5 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1
CHEMBL540542 ada2c_human Human Yes 6.8 Ki = 144.5 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
221 4 2 4 1.8 CSc1ccccc1NCC1=NCCN1
CHEMBL442045 ada2c_human Human No 5.8 Ki = 1445.4 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
267 4 1 4 2.5 CC(Oc1ccccc1-c1ccncc1)C1=NCCN1
CHEMBL219916 ada2c_human Human Yes 6.8 Ki = 147 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
425 5 2 5 3.4 Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2
CHEMBL2431282 ada2c_human Human No 6.8 Ki = 147.9 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
232 5 1 3 2.4 CCCc1ccccc1OC(C)C1=NCCN1
CHEMBL576078 ada2c_human Human No 6.8 Ki = 147.9 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
232 4 1 3 2.7 CCCc1ccccc1C(C)OC1=NCCN1
CHEMBL43491 ada2c_human Human No 5.8 Ki = 1479 nM Bind
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
510 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3C#N)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1
CHEMBL2391541 ada2c_human Human Yes 5.8 Ki = 1479.1 nM Bind
Binding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assayBinding affinity to alpha-2C adrenergic receptor (unknown origin) by competition binding assay
270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12
CHEMBL402143 ada2c_human Human No 6.8 Ki = 148 nM Bind
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
405 9 1 4 4.2 COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1
CHEMBL4455344 ada2c_human Human No 5.8 Ki = 1490 nM Bind
Displacement of [3H]Rauwolscine from human alpha 2C adrenergic receptor expressed in MDCK cells by radioligand binding assayDisplacement of [3H]Rauwolscine from human alpha 2C adrenergic receptor expressed in MDCK cells by radioligand binding assay
343 2 2 5 3.8 Clc1ccc(C#Cc2nc(NC3CCCC3)c3nc[nH]c3n2)s1
CHEMBL2205825 ada2c_human Human No 5.8 Ki = 1491 nM Bind
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
295 3 1 3 2.0 COc1ccc(CN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1
CHEMBL2112981 ada2c_human Human No 7.8 Ki = 15 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
388 5 1 5 3.2 C(=C/c1ccccc1)\CN1CCN(C[C@@H]2ON=C3c4ccccc4NC[C@H]32)CC1
CHEMBL2413154 ada2c_human Human Yes 7.8 Ki = 15 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin)Binding affinity to adrenergic alpha2C receptor (unknown origin)
373 7 0 8 0.6 COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1
CHEMBL262901 ada2c_human Human No 7.8 Ki = 15 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1
CHEMBL262901 ada2c_human Human No 7.8 Ki = 15 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
374 3 1 4 5.0 Cc1ccc2c(Nc3ccc(N4CCN(C)C(C)C4)cc3)c(C)c(C)nc2c1
CHEMBL476774 ada2c_human Human No 7.8 Ki = 15.7 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
396 6 1 6 1.7 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1
CHEMBL1628227 ada2c_human Human Yes 6.8 Ki = 150 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
279 3 0 2 4.0 CN(C)CCC=C1c2ccccc2COc2ccccc21
CHEMBL308863 ada2c_human Human No 5.8 Ki = 1500 nM Bind
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
233 4 2 4 2.5 COc1ccc(Nc2ncc[nH]2)c(C)c1OC
CHEMBL3417585 ada2c_human Human No 5.8 Ki = 1500 nM Bind
Inhibition of alpha-2C adrenergic receptor (unknown origin)Inhibition of alpha-2C adrenergic receptor (unknown origin)
327 6 1 4 2.4 C[C@@H]1CCCN1CCCOc1ccc(C2=NNC(=O)[C@@H]3C[C@H]23)cc1
CHEMBL2432038 ada2c_human Human No 5.8 Ki = 1510 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
257 3 1 1 3.3 C1CCC(CN[C@H]2C3C4CC5C6C4CC3C6C52)CC1
CHEMBL341473 ada2c_human Human Yes 5.8 Ki = 1513.6 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
191 1 1 3 1.0 CN1CCN(c2ccc(N)cc2)CC1
CHEMBL1327 ada2c_human Human Yes 4.8 Ki = 15135.6 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
256 3 1 3 2.9 OC(Cn1ccnc1)c1ccc(Cl)cc1Cl
CHEMBL490632 ada2c_human Human No 6.8 Ki = 154 nM Bind
Inhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experimentInhibition of human cloned Alpha-2C adrenergic receptor by competitive binding experiment
399 9 0 4 4.5 COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1
CHEMBL2205362 ada2c_human Human Yes 5.8 Ki = 1542 nM Bind
Displacement of [3H]clonidine from alpha2C adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2C adrenergic receptor after 40 mins by scintillation counting analysis
436 8 0 5 5.3 COc1cc2oc(C(=O)N(CCCN3CCCCC3)c3ccccc3)c(C)c2cc1OC
CHEMBL3588909 ada2c_human Human Yes 4.8 Ki = 15488.2 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
242 4 2 3 2.4 NCC(=O)Nc1ccccc1Oc1ccccc1
CHEMBL3588910 ada2c_human Human Yes 4.8 Ki = 15488.2 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
282 3 1 3 2.6 O=C(CCC1CCCC1)N1CCSC12CCNCC2
CHEMBL4084262 ada2c_human Human No 5.8 Ki = 1557 nM Funct
Displacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cells measured after 90 mins by microbeta scintillation counting method
491 8 0 7 5.4 COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1
CHEMBL327712 ada2c_human Human No 6.8 Ki = 158.5 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
631 9 2 5 7.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc(Cl)c(Cl)c1
CHEMBL492444 ada2c_human Human No 5.8 Ki = 1584.9 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
280 2 1 4 2.5 c1ccc(-c2ccc3c(c2)OCC(C2=NCCN2)O3)cc1
CHEMBL1535 ada2c_human Human Yes 4.8 Ki = 15848.9 nM Bind
Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine
335 9 2 4 3.8 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
CHEMBL216727 ada2c_human Human No 7.8 Ki = 16 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
378 3 1 4 4.9 Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C
CHEMBL597 ada2c_human Human Yes 7.8 Ki = 16 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
281 4 2 4 2.8 Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1
CHEMBL216727 ada2c_human Human No 7.8 Ki = 16 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
378 3 1 4 4.9 Cc1nc2ccc(F)cc2c(Nc2ccc(N3CCN(C)C(C)C3)cc2)c1C
CHEMBL150161 ada2c_human Human Yes 7.8 Ki = 16.4 nM Bind
Binding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assayBinding affinity to human cloned adrenergic alpha-2C receptor by radioligand binding assay
361 6 1 3 4.0 O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)C1)c1ccc(F)cc1
CHEMBL40650 ada2c_human Human No 7.8 Ki = 16.6 nM Bind
Binding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligandBinding affinity against human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand
448 4 1 7 3.0 COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21
CHEMBL223836 ada2c_human Human No 7.8 Ki = 17.0 nM Bind
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1
CHEMBL223836 ada2c_human Human No 7.8 Ki = 17.0 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
284 4 1 3 3.3 CC(Oc1ccccc1-c1cccc(F)c1)C1=NCCN1
CHEMBL134 ada2c_human Human Yes 6.8 Ki = 160 nM Bind
Binding affinity towards alpha-2C adrenergic receptorBinding affinity towards alpha-2C adrenergic receptor
229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl
CHEMBL1331786 ada2c_human Human Yes 6.8 Ki = 161 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N
CHEMBL420 ada2c_human Human Yes 6.8 Ki = 161 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
230 2 2 2 1.6 NC(=N/N=C\c1c(Cl)cccc1Cl)N
CHEMBL31410 ada2c_human Human Yes 6.8 Ki = 161 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
354 1 2 4 2.6 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12
CHEMBL27979 ada2c_human Human No 5.8 Ki = 1621.8 nM Bind
Binding affinity towards human Alpha-2C adrenergic receptorBinding affinity towards human Alpha-2C adrenergic receptor
422 7 0 4 4.5 C[C@H]1CC[C@H](C)N1CCCOc1ccc(-c2ccc(C(=O)N3CCOCC3)cc2)cc1
CHEMBL373830 ada2c_human Human No 5.8 Ki = 1621.8 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 4 2.8 CC(Oc1ccccc1-c1ccccc1O)C1=NCCN1
CHEMBL4176474 ada2c_human Human No 5.8 Ki = 1640 nM Bind
Displacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method
405 4 0 4 4.4 O=C(OCc1ccccc1)N1Cc2ccc(N3CCN(C4CCCC4)CC3)cc2C1
CHEMBL279436 ada2c_human Human No 6.8 Ki = 165 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1
CHEMBL1194763 ada2c_human Human No 6.8 Ki = 166.0 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1
CHEMBL553276 ada2c_human Human No 6.8 Ki = 166.0 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
249 5 2 4 2.6 CC(C)Sc1ccccc1NCC1=NCCN1
CHEMBL279436 ada2c_human Human No 6.8 Ki = 166.0 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1
CHEMBL75201 ada2c_human Human Yes 4.8 Ki = 16595.9 nM Bind
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine
156 0 0 4 -0.3 C1COC(N2CCOCC2)=N1
CHEMBL70751 ada2c_human Human No 6.8 Ki = 169.8 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
255 4 2 4 2.5 CSc1ccc(Cl)cc1NCC1=NCCN1
CHEMBL217665 ada2c_human Human Yes 5.8 Ki = 1698.2 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
318 3 1 4 3.7 CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1
CHEMBL10316 ada2c_human Human Yes 7.8 Ki = 17.8 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL543467 ada2c_human Human Yes 7.8 Ki = 17.8 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 nM Bind
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL10316 ada2c_human Human Yes 7.8 Ki = 17.8 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL543467 ada2c_human Human Yes 7.8 Ki = 17.8 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human Alpha-2C adrenergic receptor expressed in CHO cells after 30 mins by scintillation counting
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL374584 ada2c_human Human No 7.8 Ki = 17.8 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
282 4 2 4 2.8 CC(Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL611 ada2c_human Human Yes 6.8 Ki = 170 nM Bind
Ability to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptor
387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1
CHEMBL217665 ada2c_human Human Yes 5.8 Ki = 1700 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
318 3 1 4 3.7 CN1CCN(c2ccc(Nc3ccnc4ccccc34)cc2)CC1
CHEMBL3392246 ada2c_human Human No 5.8 Ki = 1700 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
609 10 1 8 6.0 COC(=O)C1=C(C)NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL2205812 ada2c_human Human No 5.8 Ki = 1704 nM Bind
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
309 4 1 3 2.0 COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1
CHEMBL1717 ada2c_human Human Yes 6.8 Ki = 171 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1
CHEMBL833 ada2c_human Human Yes 6.8 Ki = 171 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 2 0 2 4.0 Clc1ccccc1CN1CCc2sccc2C1
CHEMBL284213 ada2c_human Human Yes 6.8 Ki = 172 nM Bind
Binding affinity towards alpha-2C adrenergic receptorBinding affinity towards alpha-2C adrenergic receptor
204 1 1 2 2.9 c1nc(C2CCCc3sccc32)c[nH]1
CHEMBL284213 ada2c_rat Rat Yes 6.8 Ki = 172 nM Bind
in vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
204 1 1 2 2.9 c1nc(C2CCCc3sccc32)c[nH]1
CHEMBL3104091 ada2c_human Human No 6.8 Ki = 173 nM Bind
Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)
288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1
CHEMBL2413153 ada2c_human Human Yes 6.8 Ki = 173.7 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin)Binding affinity to adrenergic alpha2C receptor (unknown origin)
405 9 0 8 0.9 Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O
CHEMBL3104091 ada2c_human Human No 6.8 Ki = 173.8 nM Bind
Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)Displacement of [125I]Clonidine from adrenergic alpha2C receptor (unknown origin)
288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1
CHEMBL6310 ada2c_human Human Yes 5.8 Ki = 1740 nM Bind
Binding affinity towards Alpha-2C adrenergic receptorBinding affinity towards Alpha-2C adrenergic receptor
202 1 2 2 1.8 COc1ccc2c3c([nH]c2c1)CNCC3
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1
CHEMBL1276139 ada2c_human Human No 6.8 Ki = 177.8 nM Bind
Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
230 5 1 3 2.2 C=CCc1ccccc1O[C@H](C)C1=NCCN1
CHEMBL2205829 ada2c_human Human No 5.8 Ki = 1783 nM Bind
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
309 2 1 4 1.7 OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2
CHEMBL2205829 ada2c_human Human No 5.8 Ki = 1783 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
309 2 1 4 1.7 OC12C3C4CC5C6C4C1C6C(C53)N2Cc1ccc2c(c1)OCO2
CHEMBL246852 ada2c_human Human No 7.8 Ki = 18 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
497 6 0 5 6.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4C(F)(F)F)cc13)CC2
CHEMBL654 ada2c_human Human Yes 7.8 Ki = 18 nM Bind
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
265 0 0 3 2.5 CN1CCN2C(C1)c1ccccc1Cc1c2nccc1
CHEMBL3417586 ada2c_human Human No 5.8 Ki = 1800 nM Bind
Inhibition of alpha-2C adrenergic receptor (unknown origin)Inhibition of alpha-2C adrenergic receptor (unknown origin)
327 6 1 4 2.4 C[C@@H]1CCCN1CCCOc1ccc(C2=NNC(=O)[C@H]3C[C@@H]23)cc1
CHEMBL467094 ada2c_human Human Yes 6.7 Ki = 181 nM Bind
Displacement of [3H]Clonidine from human adrenergic Alpha-2C receptorDisplacement of [3H]Clonidine from human adrenergic Alpha-2C receptor
339 2 0 5 3.2 COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4
CHEMBL2205816 ada2c_human Human No 5.7 Ki = 1835 nM Bind
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
280 3 1 3 1.4 OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1
CHEMBL2205816 ada2c_human Human No 5.7 Ki = 1835 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
280 3 1 3 1.4 OC12C3C4CC5C6C4C1C6C(C53)N2CCc1ccccn1
CHEMBL516 ada2c_human Human Yes 6.7 Ki = 185 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
287 0 0 1 4.7 CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1
CHEMBL2205814 ada2c_human Human No 5.7 Ki = 1874 nM Bind
Binding affinity to alpha2C adrenergic receptorBinding affinity to alpha2C adrenergic receptor
339 5 1 4 2.0 COc1ccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)cc1OC
CHEMBL10316 ada2c_human Human Yes 7.7 Ki = 19 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL543467 ada2c_human Human Yes 7.7 Ki = 19 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
204 1 1 4 0.8 c1ccc2c(c1)OCC(C1=NCCN1)O2
CHEMBL246228 ada2c_human Human No 7.7 Ki = 19 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
406 5 1 9 2.5 COc1cc2c(cc1OC)CN(Cc1cnc(N)n3nc(-c4ccco4)nc13)CC2
CHEMBL246639 ada2c_human Human No 7.7 Ki = 19 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
459 7 0 6 5.7 COc1cccc(-c2cc3c(CN4CCc5cc(OC)c(OC)cc5C4)ccc(OC)c3o2)c1
CHEMBL308570 ada2c_human Human Yes 7.7 Ki = 19 nM Bind
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
231 2 2 4 2.2 Cc1c(Nc2ncc[nH]2)ccc2c1OCCO2
CHEMBL382310 ada2c_human Human No 7.7 Ki = 19 nM Bind
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
340 1 3 3 2.6 O=C(O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O
CHEMBL90997 ada2c_human Human No 7.7 Ki = 19 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
218 2 1 2 1.9 Fc1ccc2c(c1)CC(CC1CN=CN1)C2
CHEMBL90997 ada2c_human Human No 7.7 Ki = 19 nM Bind
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
218 2 1 2 1.9 Fc1ccc2c(c1)CC(CC1CN=CN1)C2
CHEMBL179648 ada2c_human Human No 7.7 Ki = 19.6 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
322 4 0 3 3.2 c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1
CHEMBL3409256 ada2c_human Human No 6.7 Ki = 190 nM Bind
Displacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cellsDisplacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cells
518 9 1 7 3.6 NC(=O)c1ccccc1OCCCN1CCN(c2cccc3c2ccn3S(=O)(=O)c2ccccc2)CC1
CHEMBL91550 ada2c_human Human No 6.7 Ki = 190.6 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
621 12 3 6 5.7 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(CC)N1
CHEMBL295395 ada2c_human Human No 5.7 Ki = 1905 nM Bind
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
542 7 1 4 4.5 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1C
CHEMBL127257 ada2c_human Human Yes 5.7 Ki = 1912 nM Bind
Inhibition of alpha2C adrenergic receptor (unknown origin)Inhibition of alpha2C adrenergic receptor (unknown origin)
320 3 1 3 3.5 Cc1ccc(cc1C)N1CCN(CC1)Cc1nc2c([nH]1)cccc2
CHEMBL1940420 ada2c_human Human Yes 6.7 Ki = 194.5 nM Bind
Displacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation countingDisplacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation counting
315 6 0 4 2.8 Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1
CHEMBL72753 ada2c_human Human Yes 6.7 Ki = 195.0 nM Bind
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
247 1 2 5 1.7 Clc1c(NC2=NCCN2)ccc2nccnc12
CHEMBL1256503 ada2c_human Human No 6.7 Ki = 195.0 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
226 2 1 2 2.5 CO[C@H]1c2ccccc2[C@H]2C[C@@]12c1c[nH]cn1
CHEMBL72441 ada2c_human Human No 6.7 Ki = 199.5 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
235 4 2 4 2.1 CSc1ccc(C)cc1NCC1=NCCN1
CHEMBL128168 ada2c_human Human Yes 6.7 Ki = 199.5 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL128168 ada2c_human Human Yes 6.7 Ki = 199.5 nM Bind
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL128168 ada2c_human Human Yes 6.7 Ki = 199.5 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL128168 ada2c_human Human Yes 6.7 Ki = 199.5 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 3 3.1 CC(Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL295001 ada2c_human Human No 5.7 Ki = 1995 nM Bind
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
528 7 2 4 4.2 CC1=C(C(=O)NCCCN2CCC(C#N)(c3ccc(F)cc3F)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1
CHEMBL217299 ada2c_human Human Yes 8.7 Ki = 2 nM Bind
Binding affinity to human cloned adrenergic alpha 2C receptor receptorBinding affinity to human cloned adrenergic alpha 2C receptor receptor
269 0 3 4 2.1 Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2
CHEMBL98889 ada2c_human Human No 8.7 Ki = 2.1 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
464 7 0 8 2.9 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C(C)=C/c4cccnc4)CC3)[C@@H]1CO2
CHEMBL268258 ada2c_human Human Yes 8.7 Ki = 2.1 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
349 6 0 3 5.0 COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1
CHEMBL268258 ada2c_human Human Yes 8.7 Ki = 2.1 nM Bind
Inhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptorInhibition of [3H]- rauwolscine binding to alpha-2C adrenergic receptor
349 6 0 3 5.0 COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1
CHEMBL1255617 ada2c_human Human No 8.7 Ki = 2.1 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1
CHEMBL761 ada2c_human Human Yes 8.6 Ki = 2.3 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
210 2 1 2 2.4 C1CN=C(N1)Cc1cccc2c1cccc2
CHEMBL425983 ada2c_human Human No 8.6 Ki = 2.3 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
386 3 1 4 5.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C
CHEMBL422597 ada2c_human Human No 8.6 Ki = 2.3 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
419 6 0 6 3.1 COc1ccc2c(c1)C1=NOC(CN3CCN(C/C=C/c4ccccc4)CC3)C1CO2
CHEMBL15245 ada2c_human Human Yes 8.6 Ki = 2.3 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
354 1 2 4 2.6 COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
CHEMBL425983 ada2c_human Human No 8.6 Ki = 2.3 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
386 3 1 4 5.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN4CCCCC4C3)cc2)c1C
CHEMBL1627 ada2c_human Human Yes 8.6 Ki = 2.4 nM Bind
Displacement of [125I]HEAT from adrenergic Alpha-2C receptorDisplacement of [125I]HEAT from adrenergic Alpha-2C receptor
462 7 2 3 4.7 CNC(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL1385840 ada2c_human Human Yes 8.6 Ki = 2.4 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
561 4 3 6 2.0 CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12
CHEMBL491419 ada2c_human Human No 8.6 Ki = 2.5 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
475 9 0 7 4.2 c1ccc(Oc2ncccc2COCCN2CCCN(CC3COc4ccccc4O3)CC2)cc1
CHEMBL1255617 ada2c_human Human No 8.6 Ki = 2.7 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1
CHEMBL2112973 ada2c_human Human No 8.6 Ki = 2.7 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
459 6 1 5 3.3 CCNC(=O)N1C[C@@H]2C(=NO[C@H]2CN2CCN(C/C=C/c3ccccc3)CC2)c2ccccc21
CHEMBL196064 ada2c_human Human No 8.6 Ki = 2.8 nM Bind
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
496 5 4 5 3.5 CC(C)(C)OC(=O)NCCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O
CHEMBL319573 ada2c_human Human No 8.6 Ki = 2.8 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccccc4F)CC3)[C@@H]1CO2
CHEMBL1255771 ada2c_human Human No 8.6 Ki = 2.8 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
210 1 1 1 2.6 C[C@]12C[C@@]1(c1c[nH]cn1)Cc1ccccc12
CHEMBL42 ada2c_human Human Yes 8.5 Ki = 2.9 nM Bind
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL590615 ada2c_human Human No 7.7 Ki = 20 nM Bind
Binding affinity to Alpha2C adrenoceptor receptorBinding affinity to Alpha2C adrenoceptor receptor
297 4 1 2 2.4 Fc1cccc(CCNC23OC4C5C6CC(C7C6C4C72)C53)c1
CHEMBL392992 ada2c_human Human No 7.7 Ki = 20 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
429 6 0 5 5.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(-c4ccccc4)cc13)CC2
CHEMBL123349 ada2c_human Human Yes 7.7 Ki = 20 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1
CHEMBL536803 ada2c_human Human Yes 7.7 Ki = 20 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
195 0 0 1 2.4 CN1CCc2cccc(Cl)c2CC1
CHEMBL1255617 ada2c_human Human No 7.7 Ki = 20.4 nM Bind
Displacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation countingDisplacement of [3H]-RX821002 from human adrenergic Alpha-2C receptor expressed in rat C6 cells after 120 mins by liquid scintillation counting
222 1 1 1 2.9 c1ccc2c(c1)[C@H]1C[C@@]1(c1c[nH]cn1)C21CC1
CHEMBL3407810 ada2c_human Human No 6.7 Ki = 200 nM Bind
Binding affinity to human adrenergic alpha-2C receptor after 90 mins by radioligand displacement assayBinding affinity to human adrenergic alpha-2C receptor after 90 mins by radioligand displacement assay
325 8 1 5 2.6 Fc1cccc(CCCNCCc2ccnc(-n3ccnc3)n2)c1
CHEMBL3547107 ada2c_human Human No 6.7 Ki = 200 nM Bind
Binding affinity to human adrenergic alpha-2C receptor after 90 mins by radioligand displacement assayBinding affinity to human adrenergic alpha-2C receptor after 90 mins by radioligand displacement assay
325 8 1 5 2.6 Fc1cccc(CCCNCCc2ccnc(-n3ccnc3)n2)c1
CHEMBL194659 ada2c_human Human No 6.7 Ki = 200 nM Bind
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
313 2 0 3 4.1 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1
CHEMBL19236 ada2c_human Human Yes 5.7 Ki = 2000 nM Bind
Binding affinity for human Alpha-2C adrenergic receptorBinding affinity for human Alpha-2C adrenergic receptor
241 2 2 6 0.8 CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC
CHEMBL323579 ada2c_human Human No 6.7 Ki = 204 nM Bind
Binding affinity against human Alpha-2c adrenergic receptorBinding affinity against human Alpha-2c adrenergic receptor
666 15 4 8 4.2 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN)N1
CHEMBL523048 ada2c_human Human No 6.7 Ki = 204.2 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
328 5 1 3 4.5 c1ccc(-c2ccccc2OC(C2=NCCN2)c2ccccc2)cc1
CHEMBL30739 ada2c_human Human No 6.7 Ki = 205 nM Bind
Binding affinity towards alpha-2C adrenergic receptorBinding affinity towards alpha-2C adrenergic receptor
232 1 1 2 3.6 Cc1sc(C)c2c1CCCC2c1c[nH]cn1
CHEMBL531 ada2c_human Human Yes 6.7 Ki = 205 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 4 1 2 4.3 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3
CHEMBL1200710 ada2c_human Human Yes 6.7 Ki = 205 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 4 0 2 4.5 CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
CHEMBL415 ada2c_human Human Yes 6.7 Ki = 205 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
314 4 0 2 4.5 CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
CHEMBL385722 ada2c_human Human No 6.7 Ki = 205 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
348 4 3 5 3.3 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1
CHEMBL30739 ada2c_rat Rat No 6.7 Ki = 205 nM Bind
in vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
232 1 1 2 3.6 Cc1sc(C)c2c1CCCC2c1c[nH]cn1
CHEMBL385722 ada2c_human Human No 6.7 Ki = 205.1 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
348 4 3 5 3.3 C[C@@H]1CN(c2ccc(Nc3c(CO)cnc4ccccc34)cc2)CCN1
CHEMBL195437 ada2c_human Human Yes 5.7 Ki = 2068 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1
CHEMBL1643902 ada2c_human Human No 5.7 Ki = 2071 nM Bind
Inhibition of Alpha-2C adrenergic receptorInhibition of Alpha-2C adrenergic receptor
297 4 0 1 3.4 CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41
CHEMBL1643902 ada2c_human Human No 5.7 Ki = 2071 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
297 4 0 1 3.4 CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41
CHEMBL25467 ada2c_human Human Yes 7.7 Ki = 21 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
263 1 0 2 4.2 C=Cc1sc2ccc(Cl)c3c2c1CN(C)CC3
CHEMBL179648 ada2c_human Human No 7.7 Ki = 21.1 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
322 4 0 3 3.2 c1ccc(CN2CCN(CC3CCc4ccccc4O3)CC2)cc1
CHEMBL611 ada2c_human Human Yes 6.7 Ki = 213 nM Bind
The compound was tested for binding affinity against alpha-2C-adrenoceptor, from human clones.The compound was tested for binding affinity against alpha-2C-adrenoceptor, from human clones.
387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1
CHEMBL74283 ada2c_human Human Yes 6.7 Ki = 213.8 nM Bind
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
295 1 4 5 1.7 Brc1c(NC2=NCCN2)ccc2c1NCCN2
CHEMBL954 ada2c_human Human Yes 6.7 Ki = 215 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1
CHEMBL305906 ada2c_human Human Yes 6.7 Ki = 217 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1
CHEMBL334255 ada2c_human Human Yes 6.7 Ki = 217 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1
CHEMBL306792 ada2c_human Human No 6.7 Ki = 218.8 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
239 4 2 4 2.0 CSc1cc(F)ccc1NCC1=NCCN1
CHEMBL70692 ada2c_human Human No 6.7 Ki = 218.8 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
239 4 2 4 2.0 CSc1c(F)cccc1NCC1=NCCN1
CHEMBL195706 ada2c_human Human No 6.7 Ki = 219 nM Bind
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
313 2 0 3 4.1 CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(F)cc3[C@H]2O1
CHEMBL726 ada2c_human Human Yes 7.7 Ki = 22 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F
CHEMBL411 ada2c_human Human Yes 5.7 Ki = 2201 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1
CHEMBL1626 ada2c_human Human Yes 6.7 Ki = 223.9 nM Bind
Activity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscineActivity of compound against Alpha 2C (ADRA2C) adrenergic receptor by displacement of [3H]-rauwolscine
343 6 0 2 5.1 Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C
CHEMBL611 ada2c_human Human Yes 6.7 Ki = 223.9 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
387 4 2 7 0.9 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1
CHEMBL3588911 ada2c_human Human Yes 4.7 Ki = 22387.2 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
243 5 1 3 2.7 Cc1ccccc1Cn1ccnc1CNC(C)C
CHEMBL98063 ada2c_human Human No 6.7 Ki = 224 nM Bind
Binding affinity against human Alpha-2C adrenergic receptorBinding affinity against human Alpha-2C adrenergic receptor
692 16 3 8 5.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCN=[N+]=[N-])N1
CHEMBL147077 ada2c_human Human No 5.7 Ki = 2244 nM Bind
Binding affinity for recombinant human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand.Binding affinity for recombinant human Alpha-2C adrenergic receptor using [3H]rauwolscine as radioligand.
589 10 3 8 3.3 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(C(=O)OC)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL2432051 ada2c_human Human No 5.6 Ki = 2283 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
341 6 1 4 2.9 COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC
CHEMBL518592 ada2c_human Human Yes 7.6 Ki = 23 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
340 4 0 5 2.7 COc1ccccc1N1CCN(CC2COc3ccccc3O2)CC1
CHEMBL2112974 ada2c_human Human No 7.6 Ki = 23 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
456 6 1 7 3.3 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc(Cl)cc4)CC3)[C@@H]1CN2
CHEMBL226636 ada2c_human Human No 7.6 Ki = 23 nM Bind
Displacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cellsDisplacement of [3H]rawolscine from human cloned adrenergic Alpha-2C receptor transfected in CHO cells
467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NOC(CN3CCN(C/C=C/c4ccc(F)cc4)CC3)C1CO2
CHEMBL419894 ada2c_human Human No 7.6 Ki = 23 nM Bind
In vitro binding affinity to human alpha-2C adrenergic receptorIn vitro binding affinity to human alpha-2C adrenergic receptor
467 7 0 7 3.3 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C/c4ccc(F)cc4)CC3)[C@@H]1CO2
CHEMBL199824 ada2c_human Human Yes 7.6 Ki = 23.7 nM Bind
Binding affinity to adrenergic alpha-2C receptorBinding affinity to adrenergic alpha-2C receptor
423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1
CHEMBL2068762 ada2c_human Human Yes 7.6 Ki = 23.7 nM Bind
Binding affinity to adrenergic alpha-2C receptorBinding affinity to adrenergic alpha-2C receptor
423 7 0 8 1.7 COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1
CHEMBL432155 ada2c_human Human No 6.6 Ki = 230 nM Bind
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
230 2 3 4 2.3 Cc1c(Nc2ncc[nH]2)ccc2c1NCCO2
CHEMBL267014 ada2c_human Human Yes 6.6 Ki = 230 nM Bind
Inhibition of alpha2C adrenergic receptor (unknown origin)Inhibition of alpha2C adrenergic receptor (unknown origin)
326 3 1 3 3.5 Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2
CHEMBL299031 ada2c_human Human Yes 5.6 Ki = 2320 nM Bind
Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2C receptor expressed in CHO cell membranes incubated for 60 minsDisplacement of [3H]RX 821002 from human recombinant adrenergic alpha-2C receptor expressed in CHO cell membranes incubated for 60 mins
398 5 1 5 3.8 CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC
CHEMBL1909065 ada2c_human Human Yes 6.6 Ki = 234 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
917 13 4 16 4.3 CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC
CHEMBL2089155 ada2c_human Human No 6.6 Ki = 234.4 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL222928 ada2c_human Human Yes 6.6 Ki = 234.4 nM Bind
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL222928 ada2c_human Human Yes 6.6 Ki = 234.4 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL222928 ada2c_human Human Yes 6.6 Ki = 234.4 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
311 5 1 5 3.0 CC(Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL223830 ada2c_human Human No 6.6 Ki = 234.4 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
280 4 1 3 3.4 Cc1ccccc1-c1ccccc1OC(C)C1=NCCN1
CHEMBL2089155 ada2c_human Human No 6.6 Ki = 234.4 nM Bind
Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
244 5 1 3 2.4 C[C@@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL1879790 ada2c_human Human Yes 6.6 Ki = 239.9 nM Bind
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysisDisplacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation counting analysis
191 1 1 3 1.0 CN1CCN(c2ccccc2N)CC1
CHEMBL2 ada2c_human Human Yes 7.6 Ki = 24 nM Bind
Ability to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptor
383 4 1 8 1.8 COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1
CHEMBL310335 ada2c_human Human No 7.6 Ki = 24.6 nM Bind
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine
210 3 1 3 2.3 CCC[C@H]1CCCCC1NC1=NCCO1
CHEMBL297752 ada2c_human Human No 7.6 Ki = 24.6 nM Bind
Inhibitory constant determined using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant determined using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
210 3 1 3 2.3 CCC[C@H]1CCCC[C@@H]1NC1=NCCO1
CHEMBL76457 ada2c_human Human Yes 5.6 Ki = 2400 nM Bind
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
237 2 2 2 2.9 Brc1ccccc1Nc1ncc[nH]1
CHEMBL508112 ada2c_human Human Yes 6.6 Ki = 241 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
332 3 0 6 5.7 c1ccc2sc(SSc3nc4ccccc4s3)nc2c1
CHEMBL88448 ada2c_human Human No 6.6 Ki = 245.5 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
622 10 1 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)N(C)CCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL91956 ada2c_human Human No 6.6 Ki = 245.5 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
594 9 2 7 6.0 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL492648 ada2c_human Human No 6.6 Ki = 245.5 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
310 3 1 5 2.5 COC1(C2=NCCN2)COc2cccc(-c3ccccc3)c2O1
CHEMBL222973 ada2c_human Human No 6.6 Ki = 245.5 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
280 4 1 3 3.4 Cc1cccc(-c2ccccc2OC(C)C2=NCCN2)c1
CHEMBL4161503 ada2c_human Human No 5.6 Ki = 2466 nM Bind
Displacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method
294 3 0 3 3.0 c1ccc(CN2Cc3ccc(N4CCOCC4)cc3C2)cc1
CHEMBL2205361 ada2c_human Human Yes 6.6 Ki = 249 nM Bind
Displacement of [3H]clonidine from alpha2C adrenergic receptor after 40 mins by scintillation counting analysisDisplacement of [3H]clonidine from alpha2C adrenergic receptor after 40 mins by scintillation counting analysis
376 6 0 3 5.3 Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12
CHEMBL477816 ada2c_human Human No 7.6 Ki = 25 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
488 8 1 7 3.5 O=C(NCCN1CCCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1
CHEMBL425803 ada2c_human Human No 7.6 Ki = 25 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
360 4 1 4 4.6 CCc1c(C)nc2ccccc2c1Nc1ccc(N2CCN(C)CC2)cc1
CHEMBL479 ada2c_human Human Yes 7.6 Ki = 25 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1
CHEMBL425803 ada2c_human Human No 7.6 Ki = 25 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
360 4 1 4 4.6 CCc1c(C)nc2ccccc2c1Nc1ccc(N2CCN(C)CC2)cc1
CHEMBL155866 ada2c_human Human No 6.6 Ki = 251.2 nM Bind
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
218 3 1 3 2.1 Cc1cccc(C)c1OC(C)C1=NCCN1
CHEMBL426900 ada2c_human Human No 6.6 Ki = 251.2 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
280 4 1 3 3.4 Cc1ccc(-c2ccccc2OC(C)C2=NCCN2)cc1
CHEMBL70973 ada2c_human Human No 5.6 Ki = 2511.9 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
267 5 2 5 0.9 CCS(=O)(=O)c1ccccc1NCC1=NCCN1
CHEMBL2432061 ada2c_human Human No 5.6 Ki = 2520 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
355 6 0 4 3.3 COc1cc(CN(C)[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC
CHEMBL4163428 ada2c_human Human No 6.6 Ki = 254 nM Bind
Displacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method
351 3 0 4 3.1 CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1
CHEMBL1108 ada2c_human Human Yes 6.6 Ki = 256 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
379 6 1 4 3.7 O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1
CHEMBL419448 ada2c_human Human No 6.6 Ki = 257.0 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
271 4 2 5 0.6 CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1
CHEMBL242693 ada2c_human Human No 6.6 Ki = 257.0 nM Bind
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL242693 ada2c_human Human No 6.6 Ki = 257.0 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
311 5 1 5 3.0 C[C@@H](Oc1ccccc1-c1cccc([N+](=O)[O-])c1)C1=NCCN1
CHEMBL284795 ada2c_human Human Yes 7.6 Ki = 26 nM Bind
Binding affinity towards alpha-2C adrenergic receptorBinding affinity towards alpha-2C adrenergic receptor
230 1 1 2 3.5 Cc1sc(C)c2c1CCC=C2c1c[nH]cn1
CHEMBL6437 ada2c_human Human Yes 7.6 Ki = 26 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
CHEMBL493439 ada2c_human Human Yes 7.6 Ki = 26 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
480 7 1 6 4.9 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21
CHEMBL50588 ada2c_human Human Yes 7.6 Ki = 26 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
480 7 1 6 4.9 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21
CHEMBL435301 ada2c_human Human No 7.6 Ki = 26 nM Bind
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
329 2 0 3 4.6 CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1
CHEMBL284795 ada2c_rat Rat Yes 7.6 Ki = 26 nM Bind
in vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligandin vitro alpha-2C adrenergic receptor binding assay from rats, using RX 821002 as the displaceable ligand
230 1 1 2 3.5 Cc1sc(C)c2c1CCC=C2c1c[nH]cn1
CHEMBL495096 ada2c_human Human Yes 7.6 Ki = 26.9 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
258 4 1 3 3.1 CC(Oc1ccccc1C1CCCC1)C1=NCCN1
CHEMBL1491 ada2c_human Human Yes 6.6 Ki = 261 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
408 8 2 7 2.3 CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
CHEMBL273485 ada2c_human Human Yes 6.6 Ki = 263.0 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
190 3 1 3 1.5 CC(Oc1ccccc1)C1=NCCN1
CHEMBL571314 ada2c_human Human No 6.6 Ki = 263.0 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
190 2 1 3 1.7 CC(OC1=NCCN1)c1ccccc1
CHEMBL273485 ada2c_human Human Yes 6.6 Ki = 263.0 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
190 3 1 3 1.5 CC(Oc1ccccc1)C1=NCCN1
CHEMBL1195368 ada2c_human Human No 5.6 Ki = 2630.3 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
281 6 2 5 1.3 CCCS(=O)(=O)c1ccccc1NCC1=NCCN1
CHEMBL554416 ada2c_human Human No 5.6 Ki = 2630.3 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
281 6 2 5 1.3 CCCS(=O)(=O)c1ccccc1NCC1=NCCN1
CHEMBL54 ada2c_human Human Yes 6.6 Ki = 268 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl
CHEMBL1190038 ada2c_human Human No 6.6 Ki = 269.2 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1
CHEMBL540035 ada2c_human Human No 6.6 Ki = 269.2 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
235 5 2 4 2.2 CCSc1ccccc1NCC1=NCCN1
CHEMBL570863 ada2c_human Human No 6.6 Ki = 269.2 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation countingDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cell membrane after 30 mins by liquid scintillation counting
204 2 1 3 2.0 Cc1ccccc1C(C)OC1=NCCN1
CHEMBL70740 ada2c_human Human No 5.6 Ki = 2691.5 nM Bind
Affinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cellsAffinity to human Alpha-2C adrenergic receptor determined by radioligand binding techniques from chinese hamster ovary (CHO) cells
279 3 2 5 0.8 O=S1(=O)CCCc2cccc(NCC3=NCCN3)c21
CHEMBL404505 ada2c_human Human Yes 4.6 Ki = 26915.4 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
186 1 1 3 1.8 c1ccc2oc(C3=NCCN3)cc2c1
CHEMBL49137 ada2c_human Human Yes 7.6 Ki = 27 nM Bind
Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells
227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12
CHEMBL19215 ada2c_human Human Yes 7.6 Ki = 27 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C
CHEMBL49137 ada2c_human Human Yes 7.6 Ki = 27 nM Bind
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12
CHEMBL106525 ada2c_human Human Yes 7.6 Ki = 28.0 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
368 3 1 4 4.9 CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
CHEMBL4633982 ada2c_human Human No 5.6 Ki = 2710 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin)Binding affinity to adrenergic alpha2C receptor (unknown origin)
492 5 2 5 5.8 O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)cc(-c2cn(-c3ccc(C(F)(F)F)cc3)nn2)c1
CHEMBL459265 ada2c_human Human Yes 6.6 Ki = 274 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1
CHEMBL64894 ada2c_human Human Yes 6.6 Ki = 274 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1
CHEMBL1956195 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL2089156 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL3769968 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Binding affinity to human alpha-2C adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2C adrenergic receptor by radioligand binding assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771384 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Binding affinity to human alpha-2C adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2C adrenergic receptor by radioligand binding assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL157955 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
246 5 1 3 2.6 CCc1cccc(CC)c1OC(C)C1=NCCN1
CHEMBL1956195 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL1956195 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
244 5 1 3 2.4 CC(Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL2089156 ada2c_human Human No 6.6 Ki = 275.4 nM Bind
Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingDisplacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
244 5 1 3 2.4 C[C@H](Oc1ccccc1CC1CC1)C1=NCCN1
CHEMBL3769968 ada2c_human Human No 6.6 Ki = 278 nM Bind
Binding affinity to human alpha-2C adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2C adrenergic receptor by radioligand binding assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771384 ada2c_human Human No 6.6 Ki = 278 nM Bind
Binding affinity to human alpha-2C adrenergic receptor by radioligand binding assayBinding affinity to human alpha-2C adrenergic receptor by radioligand binding assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL2432054 ada2c_human Human No 5.6 Ki = 2793 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
325 5 0 2 3.0 CN(CCCc1cccc(F)c1)[C@H]1C2C3CC4C2C(=O)C2C4C3C21
CHEMBL106525 ada2c_human Human Yes 7.6 Ki = 28 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
368 3 1 4 4.9 CN1CCN(CC1)c1ccc(cc1)Nc1c2ccccc2nc2c1cccc2
CHEMBL123138 ada2c_human Human No 7.6 Ki = 28 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
299 0 0 2 3.8 CN1CCc2c3c(C1)c(Br)oc3ccc2Cl
CHEMBL122404 ada2c_human Human Yes 7.6 Ki = 28 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
352 1 1 4 3.2 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@H]3C[C@H]12
CHEMBL49137 ada2c_human Human Yes 7.6 Ki = 28.2 nM Bind
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
227 1 2 5 1.3 Cc1c(NC2=NCCN2)ccc2nccnc12
CHEMBL707 ada2c_human Human Yes 6.6 Ki = 280 nM Bind
Binding affinity against Alpha-2C adrenergic receptor from human clones.Binding affinity against Alpha-2C adrenergic receptor from human clones.
451 4 2 8 1.5 COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2
CHEMBL284470 ada2c_human Human No 6.6 Ki = 281.8 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
622 11 2 7 6.8 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)NCCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL1956192 ada2c_human Human Yes 6.6 Ki = 281.8 nM Bind
Binding affinity at human alpha2C ARBinding affinity at human alpha2C AR
268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1
CHEMBL1956192 ada2c_human Human Yes 6.6 Ki = 281.8 nM Bind
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
268 3 1 3 2.2 CC(Oc1ccccc1Br)C1=NCCN1
CHEMBL73392 ada2c_human Human Yes 4.6 Ki = 28183.8 nM Bind
Binding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosinBinding affinity for human Alpha-2C adrenergic receptor from cultured LM(tk-) cells using [3H]- prazosin
308 1 1 5 2.9 Brc1c(NC2=NCCS2)ccc2nccnc12
CHEMBL621 ada2c_human Human Yes 6.6 Ki = 282 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
371 5 0 6 2.4 Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2
CHEMBL4476784 ada2c_human Human Yes 5.6 Ki = 2841 nM Funct
Displacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cell membranes measured after 90 mins by microbeta scintillation counting method
379 6 1 4 3.0 COc1ccc(OCCN2CCN(C(=O)c3cc4ccccc4[nH]3)CC2)cc1
CHEMBL296419 ada2c_human Human Yes 6.5 Ki = 285 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2
CHEMBL1182210 ada2c_human Human Yes 6.5 Ki = 285 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1
CHEMBL221753 ada2c_human Human Yes 6.5 Ki = 285 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1
CHEMBL95578 ada2c_human Human No 6.5 Ki = 286 nM Bind
Binding affinity against human Alpha-2c adrenergic receptorBinding affinity against human Alpha-2c adrenergic receptor
680 16 4 8 4.6 CCC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(COCCCN)N1
CHEMBL4167315 ada2c_human Human No 5.5 Ki = 2879 nM Bind
Displacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-Rauwolscine from human adrenergic alpha2C receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation counting method
315 4 0 2 4.9 COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1
CHEMBL289480 ada2c_human Human Yes 6.5 Ki = 288.4 nM Bind
Binding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscineBinding affinity towards human Alpha-2C adrenergic receptor by the displacement of [3H]rauwolscine
180 3 1 3 1.2 C1COC(NC(C2CC2)C2CC2)=N1
CHEMBL156336 ada2c_human Human No 6.5 Ki = 288.4 nM Bind
Displacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cellsDisplacement of [3H]RS-79948-197 from human adrenoceptor aplha 2C expressed in CHO cells
218 4 1 3 2.0 CCc1ccccc1OC(C)C1=NCCN1
CHEMBL494678 ada2c_human Human No 6.5 Ki = 290 nM Bind
Binding affinity to adrenergic Alpha-2C receptorBinding affinity to adrenergic Alpha-2C receptor
294 2 1 6 1.3 CN1CCN(c2cc(-c3ccc(C#N)cc3)nc(N)n2)CC1
CHEMBL78190 ada2c_human Human No 6.5 Ki = 290 nM Bind
Displacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cellsDisplacement of rauwolscine from human Alpha-2C adrenergic receptor expressed in CHO cells
259 3 2 3 3.8 COc1cc(C)c(Nc2ncc[nH]2)cc1C(C)(C)C
CHEMBL478026 ada2c_human Human No 8.5 Ki = 3 nM Bind
Binding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assayBinding affinity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells by radioligand binding assay
474 8 1 7 3.1 O=C(NCCN1CCN(CC2COc3ccccc3O2)CC1)c1cccnc1Oc1ccccc1
CHEMBL195925 ada2c_human Human No 8.5 Ki = 3 nM Bind
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
425 5 4 4 2.5 O=C(O)CCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O
CHEMBL92860 ada2c_human Human No 8.5 Ki = 3.1 nM Funct
Binding affinity for alpha-2C-adrenergic receptorBinding affinity for alpha-2C-adrenergic receptor
473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(Cc4ccc5ccccc5c4)CC3)[C@@H]1CO2
CHEMBL94129 ada2c_human Human No 8.5 Ki = 3.1 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
473 6 0 7 3.8 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4ccc5ccccc5c4)CC3)C1CO2
CHEMBL85 ada2c_human Human Yes 8.5 Ki = 3.2 nM Bind
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL247665 ada2c_human Human No 8.5 Ki = 3.5 nM Bind
Displacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cellsDisplacement of [3H]MK912 from adrenergic Alpha-2C receptor in HepG2 cells
533 7 0 7 4.7 COc1cc2c(cc1OC)CN(Cc1ccc(OC)c3oc(C(=O)N4CCC(N5CCCC5)CC4)cc13)CC2
CHEMBL2112971 ada2c_human Human No 8.4 Ki = 3.6 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
462 7 1 7 3.6 COc1cc2c(cc1OC)C1=NO[C@@H](CN3CCN(C/C=C(\C)c4ccccc4)CC3)[C@@H]1CN2
CHEMBL476569 ada2c_human Human No 8.4 Ki = 3.8 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
468 10 1 7 2.8 CCCCOc1cccc(C(=O)NCCN2CCCN(CC3COc4ccccc4O3)CC2)n1
CHEMBL362954 ada2c_human Human No 8.4 Ki = 3.8 nM Bind
Binding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsBinding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cells
296 4 2 5 2.6 COc1cccc(N(NC2=NCCN2)c2ccc(C)cc2)c1
CHEMBL218675 ada2c_human Human No 8.4 Ki = 3.8 nM Bind
Displacement of [3H]rauwolscine from human ADRA2C expressed in S115 cellsDisplacement of [3H]rauwolscine from human ADRA2C expressed in S115 cells
390 4 2 5 4.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO
CHEMBL6437 ada2c_human Human Yes 8.4 Ki = 3.8 nM Bind
Inhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine binding to Alpha-2C adrenergic receptor
264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
CHEMBL218675 ada2c_human Human No 8.4 Ki = 3.8 nM Bind
Binding affinity to human cloned Alpha-2C adrenergic receptorBinding affinity to human cloned Alpha-2C adrenergic receptor
390 4 2 5 4.3 Cc1nc2ccccc2c(Nc2ccc(N3CCN(C)C(C)(C)C3)cc2)c1CO
CHEMBL2112982 ada2c_human Human No 8.4 Ki = 3.9 nM Funct
Binding affinity for alpha-2C adrenergic receptorBinding affinity for alpha-2C adrenergic receptor
415 6 0 5 3.8 COc1ccc2c(c1)C=C[C@@H]1C2=NO[C@H]1CN1CCN(C/C=C/c2ccccc2)CC1
CHEMBL134 ada2c_human Human Yes 7.5 Ki = 30 nM Bind
Binding affinity for human Alpha-2C adrenergic receptorBinding affinity for human Alpha-2C adrenergic receptor
229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl
CHEMBL647 ada2c_human Human Yes 7.5 Ki = 30 nM Bind
Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells
244 1 3 4 1.9 Nc1cc(Cl)c(c(c1)Cl)NC1=NCCN1
CHEMBL134 ada2c_human Human Yes 7.5 Ki = 30 nM Bind
Compound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cellsCompound was tested in vitro for binding affinity against Alpha-2C adrenergic receptor from cloned human C-2 receptor transfected into Chinese hamster ovary (CHO) cells
229 1 2 3 2.4 Clc1cccc(c1NC1=NCCN1)Cl
CHEMBL1201156 ada2c_human Human Yes 7.5 Ki = 30 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2ccccc21
CHEMBL445 ada2c_human Human Yes 7.5 Ki = 30 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
263 3 1 1 3.8 CNCCC=C1c2ccccc2CCc2ccccc21
CHEMBL91824 ada2c_human Human No 7.5 Ki = 30 nM Bind
In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscineIn vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]rauwolscine
474 6 0 8 3.2 COc1cc2c(cc1OC)C1=NOC(CN3CCN(Cc4cnc5ccccc5c4)CC3)C1CO2
CHEMBL477608 ada2c_human Human No 7.5 Ki = 30.5 nM Funct
Antagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPRAntagonist activity at human recombinant adrenergic Alpha-2C receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization by FLIPR
467 7 2 7 2.9 CC(C)(C)Nc1ncccc1C(=O)NCCN1CCCN(CC2COc3ccccc3O2)CC1
CHEMBL778 ada2c_human Human Yes 7.5 Ki = 30.9 nM Bind
Displacement of [3H]RX 821002 from human adrenergic alpha-2c receptor expressed in CHO cells in presence of GppNHp/NaDisplacement of [3H]RX 821002 from human adrenergic alpha-2c receptor expressed in CHO cells in presence of GppNHp/Na
200 2 1 1 3.2 Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C
CHEMBL290860 ada2c_human Human No 6.5 Ki = 300 nM Bind
Ability to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptorAbility to displace [3H]rauwolscine from cloned human Alpha-2C adrenergic receptor
609 10 1 8 6.9 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL279436 ada2c_human Human No 6.5 Ki = 302 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1
CHEMBL396013 ada2c_human Human No 6.5 Ki = 302 nM Bind
Displacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX 821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL396013 ada2c_human Human No 6.5 Ki = 302 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
266 4 1 3 3.1 C[C@H](Oc1ccccc1-c1ccccc1)C1=NCCN1
CHEMBL221523 ada2c_human Human No 6.5 Ki = 302 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
311 5 1 5 3.0 CC(Oc1ccccc1-c1ccc([N+](=O)[O-])cc1)C1=NCCN1
CHEMBL1940418 ada2c_human Human No 6.5 Ki = 308.2 nM Bind
Displacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation countingDisplacement of [3H]clonidine from human Alpha-2C receptor by liquid scintillation counting
313 6 0 3 3.4 Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1
CHEMBL2429890 ada2c_human Human No 5.5 Ki = 3081 nM Bind
Inhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assayInhibition of adrenergic alpha2C receptor (unknown origin) by PDSP assay
295 3 1 3 2.7 c1cc2c(cc1CN[C@H]1C3C4CC5C6C4CC3C6C51)OCO2
CHEMBL222371 ada2c_human Human No 6.5 Ki = 309.0 nM Bind
Displacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RX821002 from human adrenergic Alpha-2C receptor expressed in CHO cells
281 4 2 4 2.7 CC(Oc1ccccc1-c1cccc(N)c1)C1=NCCN1
CHEMBL442815 ada2c_human Human No 5.5 Ki = 3090.3 nM Bind
Displacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cellsDisplacement of [3H]RS79948-197 from human recombinant adrenergic Alpha-2C receptor expressed in CHO cells
247 5 1 5 1.4 CO/N=C/c1ccccc1OC(C)C1=NCCN1
CHEMBL3217984 ada2c_human Human No 7.5 Ki = 31.6 nM Bind
Binding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assayBinding affinity to adrenergic alpha2C receptor (unknown origin) by PDSP assay
308 0 0 3 4.2 CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3
CHEMBL1278084 ada2c_human Human No 7.5 Ki = 31.6 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
282 4 2 4 2.8 C[C@@H](Oc1ccccc1-c1cccc(O)c1)C1=NCCN1
CHEMBL43860 ada2c_human Human No 6.5 Ki = 313 nM Bind
In vivo inhibitory effect against Alpha-2C adrenergic receptorIn vivo inhibitory effect against Alpha-2C adrenergic receptor
485 7 2 3 4.4 CC1=C(C(=O)NCCCN2CCC(c3ccc(F)cc3)CC2)[C@@H](c2ccc(F)c(F)c2)CC(=O)N1
CHEMBL1276247 ada2c_human Human No 6.5 Ki = 316.2 nM Bind
Displacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cellsDisplacement of [3H]RX821002 from human Alpha-2C adrenoceptor expressed in CHO cells
272 4 1 4 3.2 C[C@@H](Oc1ccccc1-c1ccsc1)C1=NCCN1
CHEMBL30008 ada2c_human Human Yes 7.5 Ki = 32 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 6 0 2 5.4 Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1
CHEMBL539027 ada2c_human Human Yes 7.5 Ki = 32 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 6 0 2 5.4 Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1
CHEMBL552659 ada2c_human Human Yes 7.5 Ki = 32 nM Bind
DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912)
404 6 0 2 5.4 Fc1ccc(C(c2ccc(F)cc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1
CHEMBL196344 ada2c_human Human No 7.5 Ki = 32 nM Bind
In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamineIn vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine
396 4 4 4 1.9 NCCCNC(=O)[C@@H]1C2C[C@H]3c4[nH]c5ccccc5c4CCN3C[C@@H]2CC[C@@H]1O
CHEMBL50720 ada2c_human Human No 7.5 Ki = 32.4 nM Bind
Inhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptorInhibitory constant, using [3H]rauwolscine in LM(tk-) cells stably transfected with cloned human Alpha-2C adrenergic receptor
286 5 1 3 3.5 c1ccc(CCC[C@H]2CCCC[C@@H]2NC2=NCCO2)cc1
CHEMBL284103 ada2c_human Human No 6.5 Ki = 323 nM Bind
Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptorInhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor
607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1
CHEMBL279436 ada2c_human Human No 6.5 Ki = 323.6 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
593 10 3 6 4.9 CC1=C(C(N)=O)C(c2ccc([N+](=O)[O-])cc2)C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)=C(C)N1
CHEMBL284103 ada2c_human Human No 6.5 Ki = 323.6 nM Bind
Binding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptorBinding affinity assayed by displacement of [3H]rauwolscine from human alpha-2C adrenergic receptor
607 10 3 6 5.2 CNC(=O)C1=C(C)NC(C)=C(C(=O)NCCCN2CCC(c3ccccc3)(c3ccccc3)CC2)C1c1ccc([N+](=O)[O-])cc1