GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1222	1662	49	None	-23	25	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1662	49	None	-23	25	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1662	49	None	-23	25	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1662	49	None	-23	25	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1662	49	None	-23	25	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2337	3254	77	None	-8	29	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3254	77	None	-8	29	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3254	77	None	-8	29	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3254	77	None	-8	29	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3254	77	None	-8	29	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5328940	100214	107	None	-1	23	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100214	107	None	-1	23	Human	6.0	pAC50	=	6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	42890	9423	59	None	-1	13	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	CHEMBL1117	9423	59	None	-1	13	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	497	3	5	10	1.0	CC(=O)[C@]1(O)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](N)[C@H](O)[C@H](C)O2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	2162	41512	100	None	-3	22	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41512	100	None	-3	22	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	47979	78208	59	None	-3311	9	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2105581	78208	59	None	-3311	9	Human	5.0	pAC50	=	5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
	2105	3052	37	None	-251	25	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3052	37	None	-251	25	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3052	37	None	-251	25	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3052	37	None	-251	25	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3052	37	None	-251	25	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	4209	3161	75	None	-891	17	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3161	75	None	-891	17	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3161	75	None	-891	17	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3161	75	None	-891	17	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3161	75	None	-891	17	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3161	75	None	-891	17	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5472	205816	75	None	-1	16	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	205816	75	None	-1	16	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	205816	75	None	-1	16	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	1028	291	71	None	-44	19	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	71	None	-44	19	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	71	None	-44	19	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	71	None	-44	19	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	71	None	-44	19	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	71	None	-44	19	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5360696	1405	30	None	-1737	11	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	6953	1405	30	None	-1737	11	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	842	1405	30	None	-1737	11	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	CHEMBL52440	1405	30	None	-1737	11	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	DB00514	1405	30	None	-1737	11	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	2200	20201	61	None	-6	12	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1256819	20201	61	None	-6	12	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1305	20201	61	None	-6	12	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	6436173	55114	45	None	-3	22	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL1617	55114	45	None	-3	22	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	785	2	5	13	6.2	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	108000	56851	39	None	-32	5	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	135418340	56851	39	None	-32	5	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1643895	56851	39	None	-32	5	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	55645	84368	8	None	-3890	11	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84368	8	None	-3890	11	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	135398735	136966	32	None	-4	27	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	136262914	136966	32	None	-4	27	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL374478	136966	32	None	-4	27	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	822	4	6	15	4.3	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	4976	203577	29	None	-1230	15	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203577	29	None	-1230	15	Human	5.0	pAC50	=	5.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	242	470	124	None	-32	33	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	124	None	-32	33	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	124	None	-32	33	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	124	None	-32	33	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	124	None	-32	33	Human	7.0	pAC50	=	7.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	213046	2383	59	None	-69	17	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2383	59	None	-69	17	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2383	59	None	-69	17	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2383	59	None	-69	17	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2383	59	None	-69	17	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	443955	204368	92	None	2	8	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204368	92	None	2	8	Human	6.0	pAC50	=	6.0	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	1613	2346	53	None	-144	34	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2346	53	None	-144	34	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2346	53	None	-144	34	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2346	53	None	-144	34	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2346	53	None	-144	34	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	11626560	200935	94	None	-1	14	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200935	94	None	-1	14	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	55483	205095	40	None	-7	11	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	CHEMBL77622	205095	40	None	-7	11	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	2540	4399	111	None	-1737	28	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4399	111	None	-1737	28	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	8550	14422	57	None	-1	7	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
	CHEMBL1200515	14422	57	None	-1	7	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	578	7	1	9	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5ccccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	10.1038/s41467-023-40064-9
	131411	15390	70	None	-4	10	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	28446253	15390	70	None	-4	10	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	CHEMBL1214598	15390	70	None	-4	10	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	476	7	1	6	5.2	CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12	10.1038/s41467-023-40064-9
	11291	98794	25	None	-331	3	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL278398	98794	25	None	-331	3	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	261	1	0	1	3.9	CN1CCC2=C(C1)C(c1ccccc1)c1ccccc12	10.1038/s41467-023-40064-9
	2583	3774	118	None	-7079	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3774	118	None	-7079	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3774	118	None	-7079	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3774	118	None	-7079	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3774	118	None	-7079	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	71496458	115562	87	None	-33	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115562	87	None	-33	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	104850	3328	96	None	-1122	28	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3328	96	None	-1122	28	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3328	96	None	-1122	28	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3328	96	None	-1122	28	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3328	96	None	-1122	28	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	5282175	14430	36	None	-14	4	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1200661	14430	36	None	-14	4	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	65948	18554	109	None	-5	6	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	CHEMBL1275868	18554	109	None	-5	6	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	2794	19378	85	None	-14	7	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1292	19378	85	None	-14	7	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	472	4	1	4	7.5	CC(C)/N=c1\cc2n(-c3ccc(Cl)cc3)c3ccccc3nc-2cc1Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	7028	52378	22	None	-102	3	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	165	3	2	2	1.3	CN[C@@H](C)[C@@H](O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1590	52378	22	None	-102	3	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	165	3	2	2	1.3	CN[C@@H](C)[C@@H](O)c1ccccc1	10.1038/s41467-023-40064-9
	2467	67423	51	None	-3	5	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	CHEMBL188921	67423	51	None	-3	5	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	8	0	5	2.8	COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1	10.1038/s41467-023-40064-9
	2375	158392	106	None	-5	2	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL409	158392	106	None	-5	2	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	430	5	2	5	2.9	CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc1ccc(C#N)c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	37264	189420	24	None	-8	3	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL513301	189420	24	None	-8	3	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	68867	78171	38	None	-61	13	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78171	38	None	-61	13	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	68602	205124	80	None	-11	4	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
	CHEMBL77921	205124	80	None	-11	4	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	200	2	1	1	3.2	Cc1cccc(C(C)c2c[nH]cn2)c1C	10.1038/s41467-023-40064-9
	2683	3832	60	None	-5	6	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	5487	3832	60	None	-5	6	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	7308	3832	60	None	-5	6	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	CHEMBL1079	3832	60	None	-5	6	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	DB00697	3832	60	None	-5	6	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	4066	204624	78	None	-870	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204624	78	None	-870	16	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	1043	1580	14	None	-208	23	Human	6.9	pAC50	=	6.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1580	14	None	-208	23	Human	6.9	pAC50	=	6.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1580	14	None	-208	23	Human	6.9	pAC50	=	6.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1580	14	None	-208	23	Human	6.9	pAC50	=	6.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1580	14	None	-208	23	Human	6.9	pAC50	=	6.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	202	1507	77	None	1	17	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1507	77	None	1	17	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1507	77	None	1	17	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1507	77	None	1	17	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1507	77	None	1	17	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	124	2979	47	None	-144	25	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2979	47	None	-144	25	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2979	47	None	-144	25	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2979	47	None	-144	25	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2979	47	None	-144	25	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2274	3171	58	None	-22	37	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3171	58	None	-22	37	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3171	58	None	-22	37	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3171	58	None	-22	37	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3171	58	None	-22	37	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	212	3804	47	None	-524	22	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3804	47	None	-524	22	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3804	47	None	-524	22	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3804	47	None	-524	22	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3804	47	None	-524	22	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	56959	31554	103	None	3	9	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31554	103	None	3	9	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31554	103	None	3	9	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	70691408	78210	0	None	3	4	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	1	2	4	1.6	CCC1C2CC3C4N(C)c5ccccc5C45CC(C2[C@H]5O)N3C1O	10.1038/s41467-023-40064-9
	CHEMBL2105617	78210	0	None	3	4	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	1	2	4	1.6	CCC1C2CC3C4N(C)c5ccccc5C45CC(C2[C@H]5O)N3C1O	10.1038/s41467-023-40064-9
	4640	78264	30	None	-11	11	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78264	30	None	-11	11	Human	5.9	pAC50	=	5.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	243	3200	91	None	-1202	5	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	3052762	3200	91	None	-1202	5	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	3502	3200	91	None	-1202	5	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	CHEMBL117287	3200	91	None	-1202	5	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	DB06480	3200	91	None	-1202	5	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	67462786	120515	56	None	-3	6	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	CHEMBL3545376	120515	56	None	-3	6	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	122282	133507	57	None	-	1	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	198	0	0	2	-0.4	CN1C(=O)N(C)C2C1N(C)C(=O)N2C	10.1038/s41467-023-40064-9
	CHEMBL3707390	133507	57	None	-	1	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	198	0	0	2	-0.4	CN1C(=O)N(C)C2C1N(C)C(=O)N2C	10.1038/s41467-023-40064-9
	3198	205511	76	None	-50	37	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201049	205511	76	None	-50	37	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL808	205511	76	None	-50	37	Human	4.9	pAC50	=	4.9	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	137	370	52	None	-6606	8	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	370	52	None	-6606	8	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	370	52	None	-6606	8	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	370	52	None	-6606	8	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	370	52	None	-6606	8	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	370	52	None	-6606	8	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2343	14452	57	None	1	4	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
	CHEMBL1201039	14452	57	None	1	4	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	431	5	2	6	2.2	NS(=O)(=O)c1cc2c(cc1Cl)N=C(CSCc1ccccc1)NS2(=O)=O	10.1038/s41467-023-40064-9
	2303	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3185	68	None	-10000	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	65859	19047	88	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	236	4	2	4	0.2	OC[C@@H](O)CN1CCN(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1288810	19047	88	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	236	4	2	4	0.2	OC[C@@H](O)CN1CCN(c2ccccc2)CC1	10.1038/s41467-023-40064-9
	5468	127226	85	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	4	1	3	3.2	CC(C(=O)O)c1ccc(C(=O)c2ccccc2)s1	10.1038/s41467-023-40064-9
	CHEMBL365795	127226	85	None	-1	3	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	4	1	3	3.2	CC(C(=O)O)c1ccc(C(=O)c2ccccc2)s1	10.1038/s41467-023-40064-9
	31101	728	40	None	-323	29	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	728	40	None	-323	29	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	728	40	None	-323	29	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	728	40	None	-323	29	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	728	40	None	-323	29	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	5311507	194813	41	None	-13	12	Human	6.8	pAC50	=	6.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194813	41	None	-13	12	Human	6.8	pAC50	=	6.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	216416	111579	48	None	-18	23	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111579	48	None	-18	23	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	1547484	939	74	None	-38	26	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	654	939	74	None	-38	26	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	9072	939	74	None	-38	26	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL43064	939	74	None	-38	26	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00568	939	74	None	-38	26	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2600	3777	74	None	-223	32	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3777	74	None	-223	32	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3777	74	None	-223	32	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3777	74	None	-223	32	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3777	74	None	-223	32	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2812	4777	101	None	-165	44	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL104	4777	101	None	-165	44	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	10.1038/s41467-023-40064-9
	54454	5256	88	None	-6	14	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5256	88	None	-6	14	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	4260	52556	31	None	-14	9	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	CHEMBL159226	52556	31	None	-14	9	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	4450	178226	69	None	-24	11	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178226	69	None	-24	11	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	4746	204889	31	None	-15	19	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204889	31	None	-15	19	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204889	31	None	-15	19	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	168871	89128	14	None	-1	13	Human	7.8	pAC50	=	7.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89128	14	None	-1	13	Human	7.8	pAC50	=	7.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	2342	598	39	None	-5	8	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	598	39	None	-5	8	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	598	39	None	-5	8	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	598	39	None	-5	8	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	598	39	None	-5	8	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	150	2507	21	None	-676	17	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2507	21	None	-676	17	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2507	21	None	-676	17	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2507	21	None	-676	17	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2507	21	None	-676	17	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	24826799	10796	104	None	-53	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10796	104	None	-53	20	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	5039	63181	17	None	-74	9	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	CHEMBL1790041	63181	17	None	-74	9	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	10	2	7	1.5	CNC(=C[N+](=O)[O-])NCCSCc1ccc(CN(C)C)o1	10.1038/s41467-023-40064-9
	49846579	106167	102	None	-7	2	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	867	13	3	11	8.7	CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCC5CCOCC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1	10.1038/s41467-023-40064-9
	CHEMBL3137309	106167	102	None	-7	2	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	867	13	3	11	8.7	CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NCC5CCOCC5)c([N+](=O)[O-])c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1	10.1038/s41467-023-40064-9
	3947	206393	53	None	-26	16	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL87708	206393	53	None	-26	16	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	30323	62483	57	None	-8	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL1563	62483	57	None	-8	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL178	62483	57	None	-8	21	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	527	4	5	11	1.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(C)=O)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	5329102	194724	86	None	-16	37	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194724	86	None	-16	37	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	124087	1388	114	None	-407	27	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1388	114	None	-407	27	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1388	114	None	-407	27	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1388	114	None	-407	27	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1388	114	None	-407	27	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	441074	19412	82	None	-13	11	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19412	82	None	-13	11	Human	4.8	pAC50	=	4.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	3294	2004	111	None	-18	23	Human	7.8	pAC50	=	7.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2004	111	None	-18	23	Human	7.8	pAC50	=	7.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2004	111	None	-18	23	Human	7.8	pAC50	=	7.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2004	111	None	-18	23	Human	7.8	pAC50	=	7.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2004	111	None	-18	23	Human	7.8	pAC50	=	7.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	2713	205269	82	None	-3	27	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205269	82	None	-3	27	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205269	82	None	-3	27	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205269	82	None	-3	27	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205269	82	None	-3	27	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205269	82	None	-3	27	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205269	82	None	-3	27	Human	5.8	pAC50	=	5.8	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	103	4151	61	None	-316	22	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4151	61	None	-316	22	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4151	61	None	-316	22	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4151	61	None	-316	22	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4151	61	None	-316	22	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	1201549	596	24	None	-426	26	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	596	24	None	-426	26	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	596	24	None	-426	26	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	596	24	None	-426	26	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	596	24	None	-426	26	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	596	24	None	-426	26	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	12574	2603	88	None	-26	8	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810	2603	88	None	-26	8	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	CHEMBL19236	2603	88	None	-26	8	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	DB09242	2603	88	None	-26	8	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	5318	15574	49	None	-5	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1200348	15574	49	None	-5	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1221	15574	49	None	-5	18	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	10.1038/s41467-023-40064-9
	3062316	33573	121	None	-3	10	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33573	121	None	-3	10	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	16363	595	53	None	-363	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	595	53	None	-363	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	595	53	None	-363	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	595	53	None	-363	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	595	53	None	-363	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	135398737	957	93	None	-6	43	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	957	93	None	-6	43	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	957	93	None	-6	43	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	957	93	None	-6	43	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	957	93	None	-6	43	Human	7.7	pAC50	=	7.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	4418	34220	85	None	-3	18	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34220	85	None	-3	18	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	118422671	2755	65	None	-660	23	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2755	65	None	-660	23	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2755	65	None	-660	23	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2755	65	None	-660	23	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2755	65	None	-660	23	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2755	65	None	-660	23	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	214	3858	58	None	-134	28	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3858	58	None	-134	28	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3858	58	None	-134	28	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3858	58	None	-134	28	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3858	58	None	-134	28	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3858	58	None	-134	28	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2335	11846	22	None	-14	34	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11846	22	None	-14	34	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11846	22	None	-14	34	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11846	22	None	-14	34	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103737	78138	0	None	-3	8	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	1830	2588	44	None	-58	11	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2588	44	None	-58	11	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2588	44	None	-58	11	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2588	44	None	-58	11	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2588	44	None	-58	11	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	2393	3332	82	None	-3981	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3332	82	None	-3981	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3332	82	None	-3981	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3332	82	None	-3981	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3332	82	None	-3981	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	3236	67607	43	None	-1	7	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1902981	67607	43	None	-1	7	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	5	0	2	3.6	CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1	10.1038/s41467-023-40064-9
	1427	2011	54	None	-2691	30	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2011	54	None	-2691	30	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2011	54	None	-2691	30	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2011	54	None	-2691	30	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2011	54	None	-2691	30	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2136	3093	30	None	-41	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3093	30	None	-41	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3093	30	None	-41	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3093	30	None	-41	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3093	30	None	-41	21	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	2220	3132	82	None	-758	17	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3132	82	None	-758	17	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3132	82	None	-758	17	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3132	82	None	-758	17	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3132	82	None	-758	17	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	4031	99311	28	None	-3	12	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	CHEMBL282121	99311	28	None	-3	12	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	429	13	0	6	4.6	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1	10.1038/s41467-023-40064-9
	16351	102728	47	None	-338	17	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102728	47	None	-338	17	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	2780	110527	36	None	-218	11	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110527	36	None	-218	11	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	11511120	78392	86	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	7	2	6	5.2	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL2110732	78392	86	None	-2	5	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	7	2	6	5.2	COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1	10.1038/s41467-023-40064-9
	107771	120246	49	None	-1	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL35228	120246	49	None	-1	9	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	517	7	2	7	6.1	COc1ccc2nc3cc(Cl)ccc3c(Nc3cc(CN4CCCC4)c(O)c(CN4CCCC4)c3)c2n1	10.1038/s41467-023-40064-9
	3052776	206554	90	None	-2	3	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	171	2	1	1	1.9	C#CCN[C@@H]1CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL887	206554	90	None	-2	3	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	171	2	1	1	1.9	C#CCN[C@@H]1CCc2ccccc21	10.1038/s41467-023-40064-9
	65709	59879	39	None	-8	13	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1729803	59879	39	None	-8	13	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	365	8	0	5	3.3	CCN(CC)CCn1c(=O)c(Cc2ccc(OC)cc2)nc2ccccc21	10.1038/s41467-023-40064-9
	25181577	78217	56	None	-7	8	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2105695	78217	56	None	-7	8	Human	4.7	pAC50	=	4.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	574	9	2	9	5.0	CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1	10.1038/s41467-023-40064-9
	2435	721	100	None	-7	10	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	395	721	100	None	-7	10	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	520	721	100	None	-7	10	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	5386	721	100	None	-7	10	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL844	721	100	None	-7	10	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	DB00484	721	100	None	-7	10	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	5440	28722	37	None	-707	16	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28722	37	None	-707	16	Human	5.7	pAC50	=	5.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	154257	178617	67	None	4	19	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178617	67	None	4	19	Human	6.7	pAC50	=	6.7	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	10219	188794	37	None	-1	10	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL493439	188794	37	None	-1	10	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	CHEMBL50588	188794	37	None	-1	10	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
	1400	1955	70	None	-17	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1955	70	None	-17	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1955	70	None	-17	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1955	70	None	-17	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1955	70	None	-17	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1955	70	None	-17	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	2169	44845	35	None	-38	12	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44845	35	None	-38	12	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	9801	91583	35	None	-6	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL24072	91583	35	None	-6	16	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	8	1	1	5.4	CC(Cc1ccccc1)NCCC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1164	1628	26	None	-3235	13	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	1626	1628	26	None	-3235	13	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	3345	1628	26	None	-3235	13	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL596	1628	26	None	-3235	13	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	DB00813	1628	26	None	-3235	13	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	336	6	0	2	4.1	CCC(=O)N(c1ccccc1)C1CCN(CC1)CCc1ccccc1	10.1038/s41467-023-40064-9
	3658	4105	53	None	-12	18	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4105	53	None	-12	18	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4105	53	None	-12	18	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4105	53	None	-12	18	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4105	53	None	-12	18	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5591	157529	90	None	-14	17	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157529	90	None	-14	17	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	2267	559	71	None	-100	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	71	None	-100	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	71	None	-100	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	71	None	-100	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	71	None	-100	14	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2318	154854	29	None	-3	15	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154854	29	None	-3	15	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	2803	954	58	None	-15	14	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	516	954	58	None	-15	14	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	704	954	58	None	-15	14	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	CHEMBL134	954	58	None	-15	14	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	DB00575	954	58	None	-15	14	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	11434515	261	6	None	-13182	11	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	11519741	261	6	None	-13182	11	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	4484	261	6	None	-13182	11	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	7449	261	6	None	-13182	11	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL1194325	261	6	None	-13182	11	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	DB08897	261	6	None	-13182	11	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	9	1	6	4.7	O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2	10.1038/s41467-023-40064-9
	2131	57405	25	None	-3	7	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1652	57405	25	None	-3	7	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	536	14	2	2	4.6	CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)Cc1ccccc1Cl)Cc1ccccc1Cl	10.1038/s41467-023-40064-9
	54682461	84684	62	None	-5	12	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84684	62	None	-5	12	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	1343	1887	62	None	-11	12	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1887	62	None	-11	12	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1887	62	None	-11	12	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1887	62	None	-11	12	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1887	62	None	-11	12	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	25102847	78219	93	None	-21	10	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78219	93	None	-21	10	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	65700	78258	28	None	-77	8	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78258	28	None	-77	8	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	2333	142333	97	None	-22	14	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142333	97	None	-22	14	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	10531	1419	21	None	-19	26	Human	7.6	pAC50	=	7.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1419	21	None	-19	26	Human	7.6	pAC50	=	7.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1419	21	None	-19	26	Human	7.6	pAC50	=	7.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1419	21	None	-19	26	Human	7.6	pAC50	=	7.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1419	21	None	-19	26	Human	7.6	pAC50	=	7.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	1960	2855	67	None	-11	19	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2855	67	None	-11	19	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2855	67	None	-11	19	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2855	67	None	-11	19	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2855	67	None	-11	19	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5282136	60282	73	None	-	1	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	431	11	1	6	2.7	O=C(C[S+]([O-])Cc1ccco1)NC/C=C\COc1cc(CN2CCCCC2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1742461	60282	73	None	-	1	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	431	11	1	6	2.7	O=C(C[S+]([O-])Cc1ccco1)NC/C=C\COc1cc(CN2CCCCC2)ccn1	10.1038/s41467-023-40064-9
	9429	202131	58	None	-275	18	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	202131	58	None	-275	18	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	260	3867	54	None	-26	9	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2775	3867	54	None	-26	9	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	656665	3867	54	None	-26	9	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL56564	3867	54	None	-26	9	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB11699	3867	54	None	-26	9	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	60065	84367	6	None	-17	11	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2218858	84367	6	None	-17	11	Human	4.6	pAC50	=	4.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@@H]2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL4743867	214031	14	None	-89	15	Human	6.6	pAC50	=	6.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	1028	291	71	None	-44	19	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	71	None	-44	19	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	71	None	-44	19	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	71	None	-44	19	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	71	None	-44	19	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	71	None	-44	19	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	3151	1461	97	None	-602	24	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1461	97	None	-602	24	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1461	97	None	-602	24	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1461	97	None	-602	24	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1461	97	None	-602	24	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	47319	26462	35	None	1	6	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1360	26462	35	None	1	6	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	4846	27985	53	None	-1	10	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	308	1	2	6	2.2	O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1	10.1038/s41467-023-40064-9
	CHEMBL1372341	27985	53	None	-1	10	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	308	1	2	6	2.2	O=C(O)c1cc(O)c2c3nc4ccccc4oc-3cc(=O)c2n1	10.1038/s41467-023-40064-9
	5639	98893	75	None	-53	13	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98893	75	None	-53	13	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	2179	167516	76	None	-2	15	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	393	5	2	5	4.5	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL1256655	167516	76	None	-2	15	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	393	5	2	5	4.5	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL43	167516	76	None	-2	15	Human	5.6	pAC50	=	5.6	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	393	5	2	5	4.5	COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	180	401	56	None	-281	38	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	56	None	-281	38	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	56	None	-281	38	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	56	None	-281	38	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	56	None	-281	38	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	26757	207976	31	None	-7	5	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL972	207976	31	None	-7	5	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	187	4	0	1	2.2	C#CCN(C)[C@H](C)Cc1ccccc1	10.1038/s41467-023-40064-9
	154417	23179	60	None	-7079	7	Human	4.5	pAC50	=	4.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	CHEMBL1331216	23179	60	None	-7079	7	Human	4.5	pAC50	=	4.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	289	4	1	4	1.9	CN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)[C@H](CO)c1ccccc1)C2	10.1038/s41467-023-40064-9
	2601	3778	33	None	1	17	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3778	33	None	1	17	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3778	33	None	1	17	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3778	33	None	1	17	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3778	33	None	1	17	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	102	4125	48	None	-2	20	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4125	48	None	-2	20	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4125	48	None	-2	20	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4125	48	None	-2	20	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4125	48	None	-2	20	Human	8.5	pAC50	=	8.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	37	777	60	None	-63	12	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	777	60	None	-63	12	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	777	60	None	-63	12	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	777	60	None	-63	12	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	777	60	None	-63	12	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	129211	3747	78	None	-660	14	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3747	78	None	-660	14	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3747	78	None	-660	14	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3747	78	None	-660	14	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3747	78	None	-660	14	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	46780481	107529	20	None	-1513	15	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107529	20	None	-1513	15	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107529	20	None	-1513	15	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107529	20	None	-1513	15	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	1782	2516	84	None	-144	14	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	241	2516	84	None	-144	14	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	4168	2516	84	None	-144	14	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	CHEMBL86	2516	84	None	-144	14	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	DB01233	2516	84	None	-144	14	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	2286	3181	51	None	-602	28	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3181	51	None	-602	28	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3181	51	None	-602	28	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3181	51	None	-602	28	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3181	51	None	-602	28	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	44112	121288	48	None	-269	12	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121288	48	None	-269	12	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	2726	918	68	None	-501	42	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	918	68	None	-501	42	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	918	68	None	-501	42	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	918	68	None	-501	42	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	918	68	None	-501	42	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	191	403	98	None	-524	36	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	98	None	-524	36	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	98	None	-524	36	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	98	None	-524	36	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	98	None	-524	36	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	228	445	28	None	-758	20	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	28	None	-758	20	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	28	None	-758	20	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	28	None	-758	20	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	28	None	-758	20	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	4413	98071	57	None	1	15	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98071	57	None	1	15	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	60753	194682	40	None	1	6	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL533	194682	40	None	1	6	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	384	14	2	4	4.2	CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1	10.1038/s41467-023-40064-9
	11079	2731	63	None	-13	7	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	2731	63	None	-13	7	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	2731	63	None	-13	7	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	2731	63	None	-13	7	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	2731	63	None	-13	7	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	2731	63	None	-13	7	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	2865	4141	73	None	-138	20	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4141	73	None	-138	20	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4141	73	None	-138	20	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4141	73	None	-138	20	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4141	73	None	-138	20	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	2351	4298	49	None	-1	22	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4298	49	None	-1	22	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4298	49	None	-1	22	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	3157	1469	71	None	-446	22	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1469	71	None	-446	22	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1469	71	None	-446	22	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1469	71	None	-446	22	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1469	71	None	-446	22	Human	6.5	pAC50	=	6.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	100	3803	58	None	-162	38	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3803	58	None	-162	38	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3803	58	None	-162	38	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3803	58	None	-162	38	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtrationCompound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3803	58	None	-162	38	Human	5.5	pAC50	=	5.5	Functional	Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by

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Ligand source activities (1 row/activity)