Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL72441 ada1a_human Human No 10.0 EC50 = 0.1 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
235 4 2 3 1.8 CC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL422477 ada1a_human Human No 9.6 EC50 = 0.3 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
258 4 1 3 2.2 C1CN=C(N1)COC2=CC=CC=C2C3=CSC=C3
CHEMBL513691 ada1a_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
262 2 0 3 1.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CN=C4
CHEMBL513691 ada1a_human Human No 9.4 EC50 = 0.4 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
262 2 0 3 1.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CN=C4
CHEMBL70751 ada1a_human Human No 9.4 EC50 = 0.4 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
256 4 2 3 2.1 CSC1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL152155 ada1a_human Human No 9.3 EC50 = 0.5 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
241 4 2 3 1.7 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CO3
CHEMBL142784 ada1a_human Human No 9.3 EC50 = 0.5 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
242 4 1 3 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=COC=C3
CHEMBL155326 ada1a_human Human No 9.2 EC50 = 0.7 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CO3
CHEMBL17491 ada1a_human Human No 9.1 EC50 = 0.8 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
242 4 3 4 0.7 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=NN3
CHEMBL414185 ada1a_human Human No 9.1 EC50 = 0.8 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL414185 ada1a_human Human No 9.1 EC50 = 0.8 Funct
Effective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determined
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL155327 ada1a_human Human No 9.1 EC50 = 0.8 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NO3
CHEMBL414185 ada1a_human Human No 9.1 EC50 = 0.8 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
233 5 2 4 1.3 COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL152693 ada1a_human Human No 9.1 EC50 = 0.9 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
271 4 2 3 2.6 CC1=C(SC=C1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL468711 ada1a_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CC=C4
CHEMBL506744 ada1a_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
280 2 0 4 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=CN=CN=C4
CHEMBL143801 ada1a_human Human No 9.0 EC50 = 1 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
258 4 1 3 2.3 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CS3
CHEMBL277375 ada1a_human Human No 9.0 EC50 = 1 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NN3
CHEMBL468711 ada1a_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CN=CC=C4
CHEMBL506744 ada1a_human Human No 9.0 EC50 = 1 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
280 2 0 4 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=CN=CN=C4
CHEMBL279136 ada1a_human Human No 8.9 EC50 = 1.3 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
242 4 1 3 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CO3
CHEMBL357129 ada1a_human Human No 8.9 EC50 = 1.3 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
241 4 2 2 1.4 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CN3
CHEMBL273316 ada1a_human Human No 8.9 EC50 = 1.3 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
270 5 2 4 1.0 CCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL275844 ada1a_human Human No 8.9 EC50 = 1.3 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CNN=C3
CHEMBL97859 ada1a_human Human No 8.9 EC50 = 1.3 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
275 7 2 4 2.7 CCC(C)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL70691 ada1a_human Human No 8.8 EC50 = 1.6 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
251 5 2 4 1.4 COC1=CC(=C(C=C1)SC)NCC2=NCCN2
CHEMBL71479 ada1a_human Human No 8.7 EC50 = 2.0 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
267 4 2 4 1.1 CC1=CC(=C(C=C1)S(=O)(=O)C)NCC2=NCCN2
CHEMBL356605 ada1a_human Human No 8.7 EC50 = 2.0 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CN=CC=C3
CHEMBL18069 ada1a_human Human No 8.7 EC50 = 2.0 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
256 4 2 4 0.7 CN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL118055 ada1a_human Human Yes 8.0 EC50 = 10 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
219 4 2 3 2.1 CSC1=CC=CC=C1NCC2=CN=CN2
CHEMBL17851 ada1a_human Human No 8.0 EC50 = 10 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C(=CC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL99559 ada1a_human Human No 8.0 EC50 = 10 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
275 8 2 4 2.6 CCCCOC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL156661 ada1a_human Human No 8.0 EC50 = 10 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
253 4 2 4 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CC=N3
CHEMBL72724 ada1a_human Human No 8.0 EC50 = 10.5 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
289 4 2 6 2.3 CSC1=C(C=C(C=C1)C(F)(F)F)NCC2=NCCN2
CHEMBL142864 ada1a_human Human Yes 7.0 EC50 = 100 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
242 4 2 3 0.7 C1CN=C(N1)COC2=CC=CC=C2C3=NC=CN3
CHEMBL98769 ada1a_human Human No 7.0 EC50 = 100 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
288 7 2 3 2.2 CCCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL17819 ada1a_human Human No 6.0 EC50 = 1000 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
270 4 2 4 1.1 CC1=NN(C(=N1)C2=CC=CC=C2NCC3=NCCN3)C
CHEMBL466916 ada1a_human Human No 6.0 EC50 = 1050 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 COC1=CC=CC(=C1)C2CCC3=C(C2)NC=N3
CHEMBL466916 ada1a_human Human No 6.0 EC50 = 1050 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 COC1=CC=CC(=C1)C2CCC3=C(C2)NC=N3
CHEMBL352225 ada1a_human Human No 7.0 EC50 = 109.7 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
256 4 2 4 1.4 CC1=NC=C(O1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL302698 ada1a_human Human No 6.0 EC50 = 1096.5 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
321 4 2 7 1.6 CS(=O)(=O)C1=C(C=C(C=C1)C(F)(F)F)NCC2=NCCN2
CHEMBL467915 ada1a_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 3 0 4 2.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3OC(F)F
CHEMBL467915 ada1a_human Human No 8.0 EC50 = 11 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 3 0 4 2.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3OC(F)F
CHEMBL287047 ada1a_human Human Yes 5.0 EC50 = 11000 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
181 4 1 3 1.3 COC1=CC(=C(C=C1)OC)CCN
CHEMBL260009 ada1a_human Human No 7.0 EC50 = 111 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
265 2 1 3 2.7 CC1=C(C=NO1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL444252 ada1a_human Human No 7.0 EC50 = 111 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
280 3 1 4 2.8 CC1=NOC(=N1)CC2=CC=CC3=C2CCC3C4=NC=CN4
CHEMBL260009 ada1a_human Human No 7.0 EC50 = 111 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
265 2 1 3 2.7 CC1=C(C=NO1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL444252 ada1a_human Human No 7.0 EC50 = 111 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
280 3 1 4 2.8 CC1=NOC(=N1)CC2=CC=CC3=C2CCC3C4=NC=CN4
CHEMBL844 ada1a_bovin Bovine Yes 6.0 EC50 = 1132 Funct
Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay
292 2 2 3 0.6 C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br
CHEMBL260575 ada1a_human Human No 5.9 EC50 = 1150 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 1 2 2.8 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=CC=N4
CHEMBL260575 ada1a_human Human No 5.9 EC50 = 1150 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 1 2 2.8 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=CC=N4
CHEMBL512062 ada1a_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
260 2 0 1 3.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL469127 ada1a_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
305 5 1 4 1.1 CNS(=O)(=O)CCC1=CC=CC=C1C2CC3=NC=CN3C2
CHEMBL512062 ada1a_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
260 2 0 1 3.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL469127 ada1a_human Human No 7.9 EC50 = 12 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
305 5 1 4 1.1 CNS(=O)(=O)CCC1=CC=CC=C1C2CC3=NC=CN3C2
CHEMBL420683 ada1a_human Human No 7.9 EC50 = 12.6 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=N3
CHEMBL117581 ada1a_human Human No 7.9 EC50 = 12.6 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
258 4 2 3 1.9 C1CCN(CC1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL13852 ada1a_human Human Yes 7.9 EC50 = 12.6 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL71001 ada1a_human Human No 7.9 EC50 = 12.6 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
283 5 2 5 0.7 COC1=CC(=C(C=C1)S(=O)(=O)C)NCC2=NCCN2
CHEMBL420683 ada1a_human Human No 7.9 EC50 = 12.6 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=N3
CHEMBL13852 ada1a_human Human Yes 7.9 EC50 = 12.6 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL341747 ada1a_human Human No 7.9 EC50 = 12.6 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
273 4 1 4 2.0 CC1=C(SN=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL17776 ada1a_human Human No 7.9 EC50 = 12.6 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
284 6 2 4 1.5 CCCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL99362 ada1a_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
246 5 3 3 1.1 CCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL13852 ada1a_human Human Yes 7.9 EC50 = 12.6 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL329928 ada1a_human Human No 7.9 EC50 = 12.6 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
247 6 2 4 1.7 CCOC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL13852 ada1a_human Human Yes 7.9 EC50 = 12.6 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
216 4 1 2 1.8 C1CC1C2=CC=CC=C2OCC3=NCCN3
CHEMBL30596 ada1a_human Human Yes 6.9 EC50 = 120 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
207 2 1 3 1.6 COC1=C2CCC(CC2=C(C=C1)OC)N
CHEMBL466296 ada1a_human Human No 6.9 EC50 = 123 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.5 C1CC2=C(CC1C3=CC=CC=C3)NC=N2
CHEMBL466296 ada1a_human Human No 6.9 EC50 = 123 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.5 C1CC2=C(CC1C3=CC=CC=C3)NC=N2
CHEMBL116843 ada1a_human Human Yes 6.9 EC50 = 125.9 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
251 4 2 4 1.4 CS(=O)(=O)C1=CC=CC=C1NCC2=CN=CN2
CHEMBL342324 ada1a_human Human No 6.9 EC50 = 125.9 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
267 4 1 3 1.9 CC1=CC=CC(=N1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL95245 ada1a_human Human Yes 6.9 EC50 = 125.9 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
272 4 2 3 1.4 C1CCN(C1)C(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL358802 ada1a_human Human No 5.9 EC50 = 1258.9 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
254 4 1 4 0.9 C1CN=C(N1)COC2=CC=CC=C2C3=NC=CC=N3
CHEMBL109848 ada1a_rabit Rabbit No 5.9 EC50 = 1288.3 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
255 2 2 2 1.9 CC(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL257801 ada1a_human Human No 5.9 EC50 = 1340 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
305 5 2 4 2.1 CCCS(=O)(=O)NC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL257801 ada1a_human Human No 5.9 EC50 = 1340 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
305 5 2 4 2.1 CCCS(=O)(=O)NC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL406316 ada1a_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.1 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CNN=C4
CHEMBL406316 ada1a_human Human No 7.9 EC50 = 14 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.1 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CNN=C4
CHEMBL71001 ada1a_human Human No 7.9 EC50 = 14.1 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
283 5 2 5 0.7 COC1=CC(=C(C=C1)S(=O)(=O)C)NCC2=NCCN2
CHEMBL257977 ada1a_human Human No 6.9 EC50 = 142 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 3 2 4 1.7 CS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=NC=CN3
CHEMBL257977 ada1a_human Human No 6.9 EC50 = 142 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 3 2 4 1.7 CS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=NC=CN3
CHEMBL466869 ada1a_human Human No 6.8 EC50 = 144 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 COC1=CC=CC=C1C2CCC3=C(C2)NC=N3
CHEMBL466869 ada1a_human Human No 6.8 EC50 = 144 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 COC1=CC=CC=C1C2CCC3=C(C2)NC=N3
CHEMBL511211 ada1a_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 1 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=CC=NN4
CHEMBL511211 ada1a_human Human No 7.8 EC50 = 15 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 1 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=CC=NN4
CHEMBL154023 ada1a_human Human No 7.8 EC50 = 15.1 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
256 4 2 4 1.4 CC1=C(OC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL116700 ada1a_human Human No 7.8 EC50 = 15.9 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
250 4 1 2 3.2 C1=CC=C(C=C1)C2=CC=CC=C2OCC3=CN=CN3
CHEMBL97044 ada1a_human Human No 7.8 EC50 = 15.9 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
258 5 3 3 1.3 C1CC1NC(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL304747 ada1a_rat Rat No 5.8 EC50 = 1500 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
250 2 0 2 2.8 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=CC=C3
CHEMBL304747 ada1a_rat Rat No 5.8 EC50 = 1500 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
250 2 0 2 2.8 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=CC=C3
CHEMBL3600395 ada1a_human Human No 5.8 EC50 = 1548 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
431 10 4 7 1.5 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)C4CC4)O
CHEMBL3600395 ada1a_human Human No 5.8 EC50 = 1548 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
431 10 4 7 1.5 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)C4CC4)O
CHEMBL115977 ada1a_human Human No 6.8 EC50 = 158.5 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
241 4 1 4 1.7 C1=CC=C(C(=C1)C2=CC=NO2)OCC3=CN=CN3
CHEMBL143766 ada1a_human Human No 6.8 EC50 = 158.5 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
273 4 1 4 2.0 CC1=NSC(=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL72958 ada1a_human Human Yes 6.8 EC50 = 158.5 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
248 4 3 6 -0.8 CS(=O)(=O)NC1=CC(=C(C=C1)F)C(CN)O
CHEMBL74467 ada1a_human Human No 7.8 EC50 = 16.6 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
271 4 2 5 0.8 CS(=O)(=O)C1=C(C=C(C=C1)F)NCC2=NCCN2
CHEMBL108804 ada1a_rabit Rabbit No 7.8 EC50 = 17.0 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
307 3 3 5 1.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=CN=CN3)O
CHEMBL449279 ada1a_human Human No 5.8 EC50 = 1650 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 1 1 2.1 C1C(CC2=CC=CC=C21)C3=NC=CN3
CHEMBL449279 ada1a_human Human No 5.8 EC50 = 1650 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 1 1 2.1 C1C(CC2=CC=CC=C21)C3=NC=CN3
CHEMBL256984 ada1a_human Human No 6.8 EC50 = 167 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 CC1=C(C2=C(C=C1)C(CC2)C3=NC=CN3)OC
CHEMBL256984 ada1a_human Human No 6.8 EC50 = 167 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 2 1 2 2.5 CC1=C(C2=C(C=C1)C(CC2)C3=NC=CN3)OC
CHEMBL473425 ada1a_human Human No 6.8 EC50 = 168 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
242 4 1 2 2.3 COCCC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL473425 ada1a_human Human No 6.8 EC50 = 168 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
242 4 1 2 2.3 COCCC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL2261355 ada1a_rabit Rabbit No 6.8 EC50 = 169.8 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
305 4 2 4 2.1 CCS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL514333 ada1a_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
282 3 1 3 2.5 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4C=CC(=N4)F
CHEMBL514333 ada1a_human Human No 7.8 EC50 = 17 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
282 3 1 3 2.5 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4C=CC(=N4)F
CHEMBL117381 ada1a_human Human No 7.8 EC50 = 17.4 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CN=CO3
CHEMBL407308 ada1a_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 1 3 2.3 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CO4
CHEMBL407308 ada1a_human Human No 6.8 EC50 = 170 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 1 3 2.3 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CO4
CHEMBL286702 ada1a_human Human No 6.8 EC50 = 170 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
247 2 1 3 2.4 COC1=C2CCC3C(C2=C(C=C1)OC)CCCN3
CHEMBL466012 ada1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
317 3 1 2 2.7 CNC(=O)C1=CC=CC(=C1)C2=CC=CC=C2C3CC4=NC=CN4C3
CHEMBL505414 ada1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
280 2 0 4 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=CN=CN=C4
CHEMBL449284 ada1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3Cl
CHEMBL466012 ada1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
317 3 1 2 2.7 CNC(=O)C1=CC=CC(=C1)C2=CC=CC=C2C3CC4=NC=CN4C3
CHEMBL505414 ada1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
280 2 0 4 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=CN=CN=C4
CHEMBL449284 ada1a_human Human No 7.7 EC50 = 19 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=CC=C3Cl
CHEMBL117381 ada1a_human Human No 7.7 EC50 = 20.0 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CN=CO3
CHEMBL17492 ada1a_human Human No 7.7 EC50 = 20.0 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
254 4 2 2 1.3 CN1C=CC=C1C2=CC=CC=C2NCC3=NCCN3
CHEMBL100383 ada1a_human Human No 7.7 EC50 = 20.0 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
289 8 2 4 3.2 CCC(CC)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL100198 ada1a_human Human No 7.7 EC50 = 20.0 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
246 4 2 3 0.9 CN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL320419 ada1a_human Human No 7.7 EC50 = 20.0 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
274 7 3 3 2.0 CCCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL322492 ada1a_rabit Rabbit No 4.7 EC50 = 19054.6 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
305 3 2 4 2.3 CS(=O)(=O)NC1=CC=CC2=C1CCCCC2C3=CN=CN3
CHEMBL74071 ada1a_human Human No 5.7 EC50 = 1949.8 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
281 5 2 4 1.5 CC(C)S(=O)(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL448510 ada1a_human Human No 6.7 EC50 = 195 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
295 4 2 5 2.7 C1CC2=C(C1C3=NC=CN3)C=CC=C2CNCC(F)(F)F
CHEMBL448510 ada1a_human Human No 6.7 EC50 = 195 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
295 4 2 5 2.7 C1CC2=C(C1C3=NC=CN3)C=CC=C2CNCC(F)(F)F
CHEMBL18436 ada1a_human Human No 6.7 EC50 = 199.5 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
298 7 2 4 1.9 CCCCN1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL448802 ada1a_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CO4
CHEMBL448802 ada1a_human Human No 8.7 EC50 = 2 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CO4
CHEMBL346380 ada1a_human Human No 8.7 EC50 = 2.2 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
257 4 2 3 2.3 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CS3
CHEMBL72768 ada1a_human Human No 8.6 EC50 = 2.3 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=C(C=C1)F)NCC2=NCCN2
CHEMBL143973 ada1a_human Human No 8.6 EC50 = 2.5 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
254 4 1 4 0.4 C1CN=C(N1)COC2=CC=CC=C2C3=NC=CN=C3
CHEMBL142871 ada1a_human Human No 8.6 EC50 = 2.5 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
259 4 1 4 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=NC=CS3
CHEMBL275902 ada1a_human Human No 8.6 EC50 = 2.5 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
268 5 2 2 1.6 CCN1C=CC=C1C2=CC=CC=C2NCC3=NCCN3
CHEMBL95523 ada1a_human Human No 8.6 EC50 = 2.5 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
232 4 3 3 0.8 CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL152725 ada1a_human Human No 8.6 EC50 = 2.7 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
255 4 2 3 2.1 CC1=CC=C(O1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL70634 ada1a_human Human No 8.6 EC50 = 2.8 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
288 4 2 4 1.4 CS(=O)(=O)C1=C(C=C(C=C1)Cl)NCC2=NCCN2
CHEMBL356195 ada1a_human Human No 7.7 EC50 = 20.9 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
246 5 2 4 1.2 CC(=NOC)C1=CC=CC=C1NCC2=NCCN2
CHEMBL33405 ada1a_human Human No 6.7 EC50 = 200 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
247 2 1 3 2.4 COC1=C2CCC3C(C2=C(C=C1)OC)CCCN3
CHEMBL260576 ada1a_human Human No 5.7 EC50 = 2060 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 1 2 2.8 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CN=CC=C4
CHEMBL260576 ada1a_human Human No 5.7 EC50 = 2060 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 1 2 2.8 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CN=CC=C4
CHEMBL109783 ada1a_human Human Yes 7.7 EC50 = 21.9 Funct
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL257977 ada1a_human Human No 5.7 EC50 = 2150 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 3 2 4 1.7 CS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=NC=CN3
CHEMBL3601200 ada1a_human Human No 6.7 EC50 = 219 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
404 9 4 7 1.3 CC1=C2C=CC(=CC2=NN1)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL3601200 ada1a_human Human No 6.7 EC50 = 219 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
404 9 4 7 1.3 CC1=C2C=CC(=CC2=NN1)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL467688 ada1a_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 0 2 1.7 COC1=CC=CC=C1C2CC3=NC=CN3C2
CHEMBL467688 ada1a_human Human No 7.7 EC50 = 22 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 0 2 1.7 COC1=CC=CC=C1C2CC3=NC=CN3C2
CHEMBL257976 ada1a_human Human No 5.7 EC50 = 2200 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
241 2 2 2 1.5 CNC(=O)C1=C2CCC(C2=CC=C1)C3=NC=CN3
CHEMBL257976 ada1a_human Human No 5.7 EC50 = 2200 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
241 2 2 2 1.5 CNC(=O)C1=C2CCC(C2=CC=C1)C3=NC=CN3
CHEMBL419448 ada1a_human Human No 7.6 EC50 = 24.0 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
271 4 2 5 0.8 CS(=O)(=O)C1=C(C=CC=C1F)NCC2=NCCN2
CHEMBL257977 ada1a_human Human No 6.6 EC50 = 234 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 3 2 4 1.7 CS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=NC=CN3
CHEMBL466296 ada1a_human Human No 6.6 EC50 = 234 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.5 C1CC2=C(CC1C3=CC=CC=C3)NC=N2
CHEMBL70973 ada1a_human Human No 6.6 EC50 = 239.9 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
267 5 2 4 1.1 CCS(=O)(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL154170 ada1a_human Human No 7.6 EC50 = 24.6 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
266 4 2 3 1.9 CC1=C(N=CC=C1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL133451 ada1a_human Human No 4.6 EC50 = 24547.1 Funct
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL257978 ada1a_human Human Yes 7.6 EC50 = 25 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
318 5 2 5 0.9 CC1=C(C=CC(=C1NS(=O)(=O)C)Cl)OCC2=NCCN2
CHEMBL257978 ada1a_human Human Yes 7.6 EC50 = 25 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
318 5 2 5 0.9 CC1=C(C=CC(=C1NS(=O)(=O)C)Cl)OCC2=NCCN2
CHEMBL142958 ada1a_human Human No 7.6 EC50 = 25.1 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
272 4 1 3 2.7 CC1=CC=C(S1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL344957 ada1a_human Human No 7.6 EC50 = 25.1 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
273 4 1 4 2.0 CC1=CSC(=N1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL417999 ada1a_human Human No 7.6 EC50 = 25.1 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
269 5 2 3 1.2 CCN1C=CC(=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL275386 ada1a_human Human No 6.6 EC50 = 251.2 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
283 6 2 3 1.7 CCCN1C(=CC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL111734 ada1a_rabit Rabbit Yes 5.6 EC50 = 2511.9 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
279 5 2 4 1.7 CCS(=O)(=O)NC1=CC=CC(=C1C)CC2=CN=CN2
CHEMBL3601201 ada1a_human Human No 6.6 EC50 = 252 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
420 10 4 8 1.2 COC1=NNC2=C1C=CC(=C2)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL3601201 ada1a_human Human No 6.6 EC50 = 252 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
420 10 4 8 1.2 COC1=NNC2=C1C=CC(=C2)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL466635 ada1a_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)N4C=CC=N4
CHEMBL466635 ada1a_human Human No 7.6 EC50 = 27 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)N4C=CC=N4
CHEMBL323402 ada1a_rabit Rabbit No 6.6 EC50 = 275.4 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
213 1 2 2 2.1 C1CC(C2=C(C1)C(=CC=C2)N)C3=CN=CN3
CHEMBL465599 ada1a_human Human No 6.6 EC50 = 276 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
233 1 1 1 3.2 C1CC2=C(CC1C3=CC=CC=C3Cl)NC=N2
CHEMBL465599 ada1a_human Human No 6.6 EC50 = 276 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
233 1 1 1 3.2 C1CC2=C(CC1C3=CC=CC=C3Cl)NC=N2
CHEMBL3601202 ada1a_human Human No 6.6 EC50 = 277 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
435 11 4 8 1.6 CCOC1=NNC2=C1C=CC(=C2)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL3601202 ada1a_human Human No 6.6 EC50 = 277 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
435 11 4 8 1.6 CCOC1=NNC2=C1C=CC(=C2)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL406348 ada1a_human Human No 6.6 EC50 = 278 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 1 2 2.2 CN1C(=CC=N1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL406348 ada1a_human Human No 6.6 EC50 = 278 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 1 2 2.2 CN1C(=CC=N1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL321644 ada1a_rabit Rabbit No 5.6 EC50 = 2818.4 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
359 4 2 7 2.8 C1CC(C2=C(C1)C(=CC=C2)NS(=O)(=O)CC(F)(F)F)C3=CN=CN3
CHEMBL466634 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=NC=CO4
CHEMBL468710 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
267 2 0 3 2.5 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CS4
CHEMBL509350 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 1 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=CC=NN4
CHEMBL260720 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 2 2 2.5 CC1=C(C=NN1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL466634 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=NC=CO4
CHEMBL468710 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
267 2 0 3 2.5 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CS4
CHEMBL509350 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 1 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)C4=CC=NN4
CHEMBL260720 ada1a_human Human No 8.5 EC50 = 3 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 2 2 2.5 CC1=C(C=NN1)C2=C3CCC(C3=CC=C2)C4=NC=CN4
CHEMBL13789 ada1a_human Human No 8.5 EC50 = 3.2 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
252 4 1 2 2.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=C3
CHEMBL13789 ada1a_human Human No 8.5 EC50 = 3.2 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
252 4 1 2 2.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=C3
CHEMBL143562 ada1a_human Human No 8.5 EC50 = 3.2 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
256 4 1 3 2.0 CC1=C(OC=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL17856 ada1a_human Human No 8.5 EC50 = 3.2 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C=CC(=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL319553 ada1a_human Human No 8.5 EC50 = 3.2 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
261 6 2 4 2.1 CC(C)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL156950 ada1a_human Human No 8.5 EC50 = 3.3 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
260 6 2 4 1.7 CCC(=NOC)C1=CC=CC=C1NCC2=NCCN2
CHEMBL325745 ada1a_human Human No 8.4 EC50 = 4.0 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
258 6 3 3 2.3 CCCNC(=O)C1=CC=CC=C1NCC2=CN=CN2
CHEMBL66433 ada1a_rat Rat Yes 5.5 EC50 = 3000 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
280 2 1 4 2.4 C1OC2=C(O1)C=C(C=C2)CC3=NNC(=O)C4=CC=CC=C43
CHEMBL66433 ada1a_rat Rat Yes 5.5 EC50 = 3000 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
280 2 1 4 2.4 C1OC2=C(O1)C=C(C=C2)CC3=NNC(=O)C4=CC=CC=C43
CHEMBL286226 ada1a_human Human No 4.5 EC50 = 30000 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
233 2 1 3 1.9 COC1=C2C3CCC(C2=C(C=C1)OC)C(C3)N
CHEMBL286609 ada1a_human Human No 4.5 EC50 = 30000 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
233 2 1 3 1.9 COC1=C2C3CCC(C2=C(C=C1)OC)C(C3)N
CHEMBL133451 ada1a_rat Rat No 4.5 EC50 = 30903.0 Funct
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL421011 ada1a_human Human No 7.5 EC50 = 31.6 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL421011 ada1a_human Human No 7.5 EC50 = 31.6 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL421011 ada1a_human Human No 7.5 EC50 = 31.6 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
274 6 2 3 1.7 CCN(CC)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL466296 ada1a_human Human No 6.5 EC50 = 315 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.5 C1CC2=C(CC1C3=CC=CC=C3)NC=N2
CHEMBL72958 ada1a_human Human Yes 6.5 EC50 = 316.2 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
248 4 3 6 -0.8 CS(=O)(=O)NC1=CC(=C(C=C1)F)C(CN)O
CHEMBL277361 ada1a_human Human No 6.5 EC50 = 316.2 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
323 5 2 6 2.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NN3CC(F)(F)F
CHEMBL402388 ada1a_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 1 2 2.2 COC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL404566 ada1a_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 4 2 4 1.5 CCS(=O)(=O)NC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL482148 ada1a_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
264 3 1 2 2.1 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4C=CC=N4
CHEMBL402388 ada1a_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 1 2 2.2 COC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL404566 ada1a_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 4 2 4 1.5 CCS(=O)(=O)NC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL482148 ada1a_human Human No 7.5 EC50 = 32 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
264 3 1 2 2.1 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4C=CC=N4
CHEMBL402003 ada1a_human Human No 6.5 EC50 = 322 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
285 2 2 2 2.8 C1CC2=C(C1C3=NC=CN3)C=CC(=C2C4=CC=NN4)Cl
CHEMBL402003 ada1a_human Human No 6.5 EC50 = 322 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
285 2 2 2 2.8 C1CC2=C(C1C3=NC=CN3)C=CC(=C2C4=CC=NN4)Cl
CHEMBL152154 ada1a_human Human No 6.5 EC50 = 323.6 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
256 4 2 4 1.4 CC1=NC(=CO1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL501404 ada1a_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=NC=CO4
CHEMBL3601310 ada1a_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
420 10 5 8 0.1 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)CO)O
CHEMBL255938 ada1a_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 3 2 4 1.5 CC1=C(C2=C(C=C1)C(CC2)C3=NC=CN3)NS(=O)(=O)C
CHEMBL501404 ada1a_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
269 2 0 4 1.9 C1C(CN2C1=NC=C2)C3=C(C=C(C=C3)F)C4=NC=CO4
CHEMBL3601310 ada1a_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
420 10 5 8 0.1 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)CO)O
CHEMBL255938 ada1a_human Human No 7.5 EC50 = 33 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
291 3 2 4 1.5 CC1=C(C2=C(C=C1)C(CC2)C3=NC=CN3)NS(=O)(=O)C
CHEMBL285082 ada1a_human Human No 6.5 EC50 = 340 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
205 2 1 3 1.1 COC1=C2CC3C(C3N)C2=C(C=C1)OC
CHEMBL467495 ada1a_human Human No 5.5 EC50 = 3460 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=C(C=C3)Cl
CHEMBL467495 ada1a_human Human No 5.5 EC50 = 3460 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
219 1 0 1 2.4 C1C(CN2C1=NC=C2)C3=CC=C(C=C3)Cl
CHEMBL351543 ada1a_human Human No 7.4 EC50 = 36.3 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
271 4 2 3 2.7 CC1=CC=C(S1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL473424 ada1a_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
228 3 1 2 1.9 COCC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL473424 ada1a_human Human No 7.4 EC50 = 37 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
228 3 1 2 1.9 COCC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL511576 ada1a_human Human No 6.4 EC50 = 371 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
227 2 1 2 0.6 C1C(CN2C1=NC=C2)C3=CC=CC=C3C(=O)N
CHEMBL511576 ada1a_human Human No 6.4 EC50 = 371 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
227 2 1 2 0.6 C1C(CN2C1=NC=C2)C3=CC=CC=C3C(=O)N
CHEMBL347268 ada1a_human Human No 7.4 EC50 = 38.9 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
256 4 2 4 1.4 CC1=NOC(=C1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL258007 ada1a_human Human No 6.4 EC50 = 385 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.7 C1CC(C2=CC=CC=C2C1)C3=NC=CN3
CHEMBL258007 ada1a_human Human No 6.4 EC50 = 385 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 1 1 2.7 C1CC(C2=CC=CC=C2C1)C3=NC=CN3
CHEMBL142967 ada1a_human Human No 7.4 EC50 = 39.8 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
256 4 1 3 0.9 CN1C(=CC=N1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL329272 ada1a_human Human No 7.4 EC50 = 39.8 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
287 6 2 4 2.6 C1CCC(C1)OC(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL63976 ada1a_rat Rat Yes 5.4 EC50 = 3900 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
271 2 1 2 3.2 C1=CC=C2C(=C1)C(=NNC2=O)CC3=CC=C(C=C3)Cl
CHEMBL63976 ada1a_rat Rat Yes 5.4 EC50 = 3900 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
271 2 1 2 3.2 C1=CC=C2C(=C1)C(=NNC2=O)CC3=CC=C(C=C3)Cl
CHEMBL273312 ada1a_human Human No 6.4 EC50 = 398.1 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C=C(C=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL95333 ada1a_human Human No 6.4 EC50 = 398.1 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
286 4 2 3 1.8 C1CCN(CC1)C(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL513871 ada1a_human Human No 8.4 EC50 = 4 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
353 4 1 4 2.4 CS(=O)(=O)NC1=CC=CC(=C1)C2=CC=CC=C2C3CC4=NC=CN4C3
CHEMBL513871 ada1a_human Human No 8.4 EC50 = 4 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
353 4 1 4 2.4 CS(=O)(=O)NC1=CC=CC(=C1)C2=CC=CC=C2C3CC4=NC=CN4C3
CHEMBL434074 ada1a_human Human No 8.4 EC50 = 4.5 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
272 4 2 4 2.0 CC1=NC(=CS1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL349082 ada1a_human Human No 8.3 EC50 = 4.6 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
253 4 2 4 0.5 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CN=C3
CHEMBL74114 ada1a_human Human No 7.4 EC50 = 41.7 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
271 4 2 5 0.8 CS(=O)(=O)C1=CC=CC(=C1NCC2=NCCN2)F
CHEMBL511411 ada1a_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
202 1 0 2 1.9 C1C(CN2C1=NC=C2)C3=CC=CC=C3F
CHEMBL511411 ada1a_human Human No 7.4 EC50 = 42 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
202 1 0 2 1.9 C1C(CN2C1=NC=C2)C3=CC=CC=C3F
CHEMBL156893 ada1a_human Human No 7.4 EC50 = 42.7 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
268 4 3 5 0.5 C1CN=C(N1)CNC2=CC=CC=C2C3=NC(=NC=C3)N
CHEMBL260116 ada1a_human Human No 6.4 EC50 = 426 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
267 2 1 3 2.9 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CS4
CHEMBL260116 ada1a_human Human No 6.4 EC50 = 426 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
267 2 1 3 2.9 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=NC=CS4
CHEMBL256982 ada1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
326 3 2 4 2.3 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NC=CN3)Cl
CHEMBL256982 ada1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
326 3 2 4 2.3 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NC=CN3)Cl
CHEMBL256982 ada1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
326 3 2 4 2.3 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NC=CN3)Cl
CHEMBL256982 ada1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
326 3 2 4 2.3 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NC=CN3)Cl
CHEMBL256982 ada1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
326 3 2 4 2.3 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NC=CN3)Cl
CHEMBL256982 ada1a_human Human No 7.4 EC50 = 43 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
326 3 2 4 2.3 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NC=CN3)Cl
CHEMBL70326 ada1a_human Human No 6.4 EC50 = 436.5 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
271 4 2 5 0.8 CS(=O)(=O)C1=C(C=CC(=C1)F)NCC2=NCCN2
CHEMBL207277 ada1a_rat Rat Yes 5.4 EC50 = 4400 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
311 4 0 2 4.1 C=CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL207277 ada1a_rat Rat Yes 5.4 EC50 = 4400 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
311 4 0 2 4.1 C=CCN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL111554 ada1a_rabit Rabbit No 6.4 EC50 = 446.7 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
291 3 2 4 1.7 CS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL154346 ada1a_human Human No 7.3 EC50 = 45.7 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CON=C3
CHEMBL255937 ada1a_human Human No 6.4 EC50 = 451 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
249 2 1 2 2.8 COC1=C(C=CC2=C1CCC2C3=NC=CN3)Cl
CHEMBL255937 ada1a_human Human No 6.4 EC50 = 451 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
249 2 1 2 2.8 COC1=C(C=CC2=C1CCC2C3=NC=CN3)Cl
CHEMBL258178 ada1a_human Human No 6.3 EC50 = 473 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 1 1 2.2 C1CC2=CC=CC=C2C1C3=NC=CN3
CHEMBL258178 ada1a_human Human No 6.3 EC50 = 473 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 1 1 2.2 C1CC2=CC=CC=C2C1C3=NC=CN3
CHEMBL258178 ada1a_human Human No 6.3 EC50 = 473 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 1 1 2.2 C1CC2=CC=CC=C2C1C3=NC=CN3
CHEMBL258178 ada1a_human Human No 6.3 EC50 = 473 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 1 1 2.2 C1CC2=CC=CC=C2C1C3=NC=CN3
CHEMBL466876 ada1a_human Human No 7.3 EC50 = 48 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
242 3 1 2 2.2 COCC1=CC=CC=C1C2CCC3=C(C2)NC=N3
CHEMBL448908 ada1a_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 0 2 1.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3N4C=CC=N4
CHEMBL510023 ada1a_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)N4C=CC=N4
CHEMBL448908 ada1a_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 0 2 1.7 C1C(CN2C1=NC=C2)C3=CC=CC=C3N4C=CC=N4
CHEMBL510023 ada1a_human Human No 8.3 EC50 = 5 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
268 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC(=C3)F)N4C=CC=N4
CHEMBL117248 ada1a_human Human No 8.3 EC50 = 5.0 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
221 4 2 3 1.4 CSC1=CC=CC=C1NCC2=NCCN2
CHEMBL142387 ada1a_human Human No 8.3 EC50 = 5.0 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
259 4 1 4 1.6 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NS3
CHEMBL344551 ada1a_human Human No 8.3 EC50 = 5.0 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
242 4 2 3 0.9 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NN3
CHEMBL336161 ada1a_rat Rat No 8.3 EC50 = 5.2 Funct
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL336161 ada1a_human Human No 8.3 EC50 = 5.6 Funct
In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL109783 ada1a_rat Rat Yes 8.2 EC50 = 5.8 Funct
In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL117094 ada1a_human Human No 7.3 EC50 = 50.1 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
253 4 2 4 0.7 CS(=O)(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL326067 ada1a_human Human No 7.3 EC50 = 50.1 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
240 4 2 4 1.7 C1=CC=C(C(=C1)C2=CN=CO2)NCC3=CN=CN3
CHEMBL325648 ada1a_human Human Yes 7.3 EC50 = 50.1 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
256 4 2 3 2.5 C1CCN(CC1)C2=CC=CC=C2NCC3=CN=CN3
CHEMBL441412 ada1a_human Human No 7.3 EC50 = 50.1 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
268 4 2 2 1.7 CC1=CC=C(N1C)C2=CC=CC=C2NCC3=NCCN3
CHEMBL450018 ada1a_human Human No 7.3 EC50 = 50.1 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
260 5 2 3 1.3 CCN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL98016 ada1a_human Human No 7.3 EC50 = 50.1 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
260 5 3 3 1.6 CC(C)NC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL432192 ada1a_human Human No 6.3 EC50 = 501.2 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
274 6 3 3 2.1 CCC(C)NC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL95398 ada1a_human Human No 6.3 EC50 = 501.2 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
275 7 2 4 2.7 CC(C)COC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL466046 ada1a_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
209 1 0 2 1.5 C1C(CN2C1=NC=C2)C3=CC=CC=C3C#N
CHEMBL467916 ada1a_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
209 1 0 2 1.5 C1C(CN2C1=NC=C2)C3=CC=CC=C3C#N
CHEMBL611 ada1a_human Human Yes 7.3 EC50 = 51 Funct
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL466046 ada1a_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
209 1 0 2 1.5 C1C(CN2C1=NC=C2)C3=CC=CC=C3C#N
CHEMBL467916 ada1a_human Human No 7.3 EC50 = 51 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
209 1 0 2 1.5 C1C(CN2C1=NC=C2)C3=CC=CC=C3C#N
CHEMBL611 ada1a_human Human Yes 7.3 EC50 = 51 Funct
Antagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assayAntagonist activity at alpha-1A adrenergic receptor (unknown origin) incubated for 30 mins prior to agonist addition measured after 5 hrs by CCF4-AM staining-based cellular assay
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL351542 ada1a_human Human No 7.3 EC50 = 51.3 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
232 5 2 4 1.0 CON=CC1=CC=CC=C1NCC2=NCCN2
CHEMBL611 ada1a_human Human Yes 7.3 EC50 = 51.9 Funct
Intrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assayIntrinsic activity at alpha1A adrenergic receptor (unknown origin) assessed as inhibition of agonist induced effect preincubated for 30 mins followed by agonist addition measured after 5 hrs in presence of CCF4-AM by cell based beta lactamase reporter gene assay
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL70563 ada1a_human Human No 6.3 EC50 = 512.9 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
288 4 2 4 1.4 CS(=O)(=O)C1=C(C=CC(=C1)Cl)NCC2=NCCN2
CHEMBL503269 ada1a_human Human No 6.3 EC50 = 514 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
233 1 1 1 3.2 C1CC2=C(CC1C3=CC(=CC=C3)Cl)NC=N2
CHEMBL503269 ada1a_human Human No 6.3 EC50 = 514 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
233 1 1 1 3.2 C1CC2=C(CC1C3=CC(=CC=C3)Cl)NC=N2
CHEMBL256983 ada1a_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.2 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=NN4
CHEMBL256983 ada1a_human Human No 7.3 EC50 = 52 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
250 2 2 2 2.2 C1CC2=C(C=CC=C2C1C3=NC=CN3)C4=CC=NN4
CHEMBL346465 ada1a_human Human No 7.3 EC50 = 52.5 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
260 6 2 4 1.6 CCON=C(C)C1=CC=CC=C1NCC2=NCCN2
CHEMBL284486 ada1a_human Human No 5.3 EC50 = 5300 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
221 2 1 3 2.0 COC1=C2CCCC(CC2=C(C=C1)OC)N
CHEMBL111584 ada1a_rabit Rabbit No 5.3 EC50 = 5495.4 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
305 3 1 4 1.7 CN1C=C(N=C1)C2CCCC3=C2C=CC=C3NS(=O)(=O)C
CHEMBL325897 ada1a_rabit Rabbit No 5.3 EC50 = 5623.4 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
317 4 2 4 2.3 C1CC(C2=C(C1)C(=CC=C2)NS(=O)(=O)C3CC3)C4=CN=CN4
CHEMBL507755 ada1a_human Human No 6.2 EC50 = 578 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 0 2 1.7 COC1=CC=CC(=C1)C2CC3=NC=CN3C2
CHEMBL507755 ada1a_human Human No 6.2 EC50 = 578 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 0 2 1.7 COC1=CC=CC(=C1)C2CC3=NC=CN3C2
CHEMBL114669 ada1a_human Human No 8.2 EC50 = 6.3 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
241 3 3 3 1.8 C1CN=C(N1)CNC2=CC=CC3=C2C=C(C=C3)O
CHEMBL327005 ada1a_human Human No 8.2 EC50 = 6.3 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
243 4 1 4 1.0 C1CN=C(N1)COC2=CC=CC=C2C3=CC=NO3
CHEMBL17151 ada1a_human Human No 8.2 EC50 = 6.3 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
284 5 2 4 1.4 CC(C)N1C(=NC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL18256 ada1a_human Human No 8.2 EC50 = 6.3 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
255 4 2 3 0.7 CN1C=CN=C1C2=CC=CC=C2NCC3=NCCN3
CHEMBL154298 ada1a_human Human No 8.2 EC50 = 6.8 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
252 4 2 3 1.5 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=N3
CHEMBL326702 ada1a_rabit Rabbit No 7.2 EC50 = 60 Funct
Agonist activity at rabbit urethra adrenergic alpha1A receptorAgonist activity at rabbit urethra adrenergic alpha1A receptor
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL326702 ada1a_rabit Rabbit No 7.2 EC50 = 60 Funct
Agonist activity at rabbit urethra adrenergic alpha1A receptorAgonist activity at rabbit urethra adrenergic alpha1A receptor
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL326702 ada1a_human Human No 6.2 EC50 = 600 Funct
Effective concentration in vitro against rabbit urethra Alpha-1A adrenergic receptorEffective concentration in vitro against rabbit urethra Alpha-1A adrenergic receptor
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL326702 ada1a_rabit Rabbit No 6.2 EC50 = 602.6 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL3601203 ada1a_human Human No 7.2 EC50 = 61 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
425 9 4 7 1.9 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)Cl)O
CHEMBL3601203 ada1a_human Human No 7.2 EC50 = 61 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
425 9 4 7 1.9 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)Cl)O
CHEMBL467259 ada1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
280 2 0 4 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC=C3F)C4=CN=CN=C4
CHEMBL502078 ada1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
246 3 1 3 2.0 COCC1=C(C=CC2=C1CCC2C3=NC=CN3)F
CHEMBL473043 ada1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
242 4 1 2 2.2 CCOCC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL467259 ada1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
280 2 0 4 1.8 C1C(CN2C1=NC=C2)C3=C(C=CC=C3F)C4=CN=CN=C4
CHEMBL502078 ada1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
246 3 1 3 2.0 COCC1=C(C=CC2=C1CCC2C3=NC=CN3)F
CHEMBL473043 ada1a_human Human No 7.2 EC50 = 62 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
242 4 1 2 2.2 CCOCC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL117482 ada1a_human Human No 7.2 EC50 = 63.1 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
272 6 2 3 2.3 CCN(CC)C(=O)C1=CC=CC=C1NCC2=CN=CN2
CHEMBL114054 ada1a_human Human No 7.2 EC50 = 63.1 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
239 3 3 3 2.5 C1=CC2=C(C=C(C=C2)O)C(=C1)NCC3=CN=CN3
CHEMBL17221 ada1a_human Human No 7.2 EC50 = 63.1 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
269 5 2 3 1.2 CCN1C(=CC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL761 ada1a_human Human Yes 7.2 EC50 = 63.1 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
210 2 1 1 2.1 C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
CHEMBL761 ada1a_human Human Yes 7.2 EC50 = 63.1 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
210 2 1 1 2.1 C1CN=C(N1)CC2=CC=CC3=CC=CC=C32
CHEMBL111496 ada1a_rabit Rabbit No 6.2 EC50 = 631.0 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
305 4 2 4 2.1 CCS(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL480272 ada1a_human Human No 6.2 EC50 = 658 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
246 3 1 3 2.0 COCC1=C2CCC(C2=C(C=C1)F)C3=NC=CN3
CHEMBL480272 ada1a_human Human No 6.2 EC50 = 658 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
246 3 1 3 2.0 COCC1=C2CCC(C2=C(C=C1)F)C3=NC=CN3
CHEMBL111771 ada1a_rabit Rabbit No 7.2 EC50 = 66.1 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
291 4 2 4 1.5 CCS(=O)(=O)NC1=CC=CC2=C1CCC2C3=CN=CN3
CHEMBL347920 ada1a_human Human No 6.2 EC50 = 660.7 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
257 4 2 5 1.2 CC1=NOC(=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL350906 ada1a_human Human No 6.2 EC50 = 676.1 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
320 4 2 6 2.4 C1CN=C(N1)CNC2=CC=CC=C2C3=C(C=CC=N3)C(F)(F)F
CHEMBL111537 ada1a_rabit Rabbit No 5.2 EC50 = 6760.8 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
319 4 2 4 2.5 CC(C)S(=O)(=O)NC1=CC=CC2=C1CCCC2C3=CN=CN3
CHEMBL306792 ada1a_human Human No 8.1 EC50 = 7.8 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=CC(=C1)F)NCC2=NCCN2
CHEMBL70692 ada1a_human Human No 8.1 EC50 = 7.8 Funct
Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor
239 4 2 4 1.5 CSC1=C(C=CC=C1F)NCC2=NCCN2
CHEMBL318544 ada1a_human Human No 8.1 EC50 = 7.9 Funct
Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL337862 ada1a_human Human No 8.1 EC50 = 7.9 Funct
Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway
251 4 2 2 2.6 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=CC=C3
CHEMBL318544 ada1a_human Human No 8.1 EC50 = 7.9 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL98243 ada1a_human Human No 8.1 EC50 = 7.9 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
275 6 2 4 2.3 CC(C)(C)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL257800 ada1a_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
277 3 2 4 1.2 CS(=O)(=O)NC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL465963 ada1a_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 0 1 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3
CHEMBL257800 ada1a_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
277 3 2 4 1.2 CS(=O)(=O)NC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL465963 ada1a_human Human No 7.2 EC50 = 70 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 0 1 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3
CHEMBL1076 ada1a_rabit Rabbit Yes 5.2 EC50 = 7079.5 Funct
Agonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethraAgonist activity at alpha1A adrenoreceptor in Oryctolagus cuniculus (rabbit) urethra
197 4 2 4 0.1 COC1=CC(=C(C=C1)OC)C(CN)O
CHEMBL1076 ada1a_human Human Yes 5.2 EC50 = 7100 Funct
Effective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptorEffective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptor
197 4 2 4 0.1 COC1=CC(=C(C=C1)OC)C(CN)O
CHEMBL287587 ada1a_human Human Yes 4.2 EC50 = 71000 Funct
Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex
187 2 4 5 -0.5 C1=CC(=C(C(=C1C(CN)O)F)O)O
CHEMBL524 ada1a_human Human Yes 6.1 EC50 = 720 Funct
Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery
211 4 2 4 0.5 CC(C(C1=C(C=CC(=C1)OC)OC)O)N
CHEMBL466914 ada1a_human Human Yes 6.1 EC50 = 721 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 0 1 2.1 C1CC2=NC=CN2CC1C3=CC=CC=C3
CHEMBL466914 ada1a_human Human Yes 6.1 EC50 = 721 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
198 1 0 1 2.1 C1CC2=NC=CN2CC1C3=CC=CC=C3
CHEMBL358685 ada1a_human Human No 6.1 EC50 = 724.4 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
257 4 2 5 1.2 CC1=NC(=NO1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL465963 ada1a_human Human No 7.1 EC50 = 73 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 0 1 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3
CHEMBL466876 ada1a_human Human No 7.1 EC50 = 76 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
242 3 1 2 2.2 COCC1=CC=CC=C1C2CCC3=C(C2)NC=N3
CHEMBL466876 ada1a_human Human No 7.1 EC50 = 76 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
242 3 1 2 2.2 COCC1=CC=CC=C1C2CCC3=C(C2)NC=N3
CHEMBL257799 ada1a_human Human No 7.1 EC50 = 78 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
285 2 2 2 2.7 C1CC2=C(C1C3=NC=CN3)C=CC(=C2C4=CNN=C4)Cl
CHEMBL257799 ada1a_human Human No 7.1 EC50 = 78 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
285 2 2 2 2.7 C1CC2=C(C1C3=NC=CN3)C=CC(=C2C4=CNN=C4)Cl
CHEMBL257799 ada1a_human Human No 7.1 EC50 = 78 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
285 2 2 2 2.7 C1CC2=C(C1C3=NC=CN3)C=CC(=C2C4=CNN=C4)Cl
CHEMBL257799 ada1a_human Human No 7.1 EC50 = 78 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
285 2 2 2 2.7 C1CC2=C(C1C3=NC=CN3)C=CC(=C2C4=CNN=C4)Cl
CHEMBL17764 ada1a_human Human No 7.1 EC50 = 79.4 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
324 5 2 7 1.7 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=NN3CC(F)(F)F
CHEMBL95565 ada1a_human Human No 7.1 EC50 = 79.4 Funct
Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.
274 6 3 3 2.1 CC(C)CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL17657 ada1a_human Human No 6.1 EC50 = 794.3 Funct
Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells
256 4 3 4 1.1 CC1=NC(=NN1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL512289 ada1a_human Human No 7.1 EC50 = 81 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=NC=C4
CHEMBL512289 ada1a_human Human No 7.1 EC50 = 81 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
261 2 0 2 2.3 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=CC=NC=C4
CHEMBL67457 ada1a_rat Rat Yes 6.1 EC50 = 810 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
285 2 0 2 3.4 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL67457 ada1a_rat Rat Yes 6.1 EC50 = 810 Funct
Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction
285 2 0 2 3.4 CN1C(=O)C2=CC=CC=C2C(=N1)CC3=CC=C(C=C3)Cl
CHEMBL3601308 ada1a_human Human No 6.1 EC50 = 812 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
458 9 4 10 1.8 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)C(F)(F)F)O
CHEMBL3601308 ada1a_human Human No 6.1 EC50 = 812 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
458 9 4 10 1.8 CS(=O)(=O)NC1=CC=CC(=C1)C(CNCCOC2=CC3=NNC(=C3C=C2)C(F)(F)F)O
CHEMBL511577 ada1a_human Human No 7.1 EC50 = 82 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 3 0 2 1.4 COCC1=CC=CC=C1C2CC3=NC=CN3C2
CHEMBL511577 ada1a_human Human No 7.1 EC50 = 82 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
228 3 0 2 1.4 COCC1=CC=CC=C1C2CC3=NC=CN3C2
CHEMBL465963 ada1a_human Human No 7.1 EC50 = 83 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
184 1 0 1 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3
CHEMBL499180 ada1a_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
276 3 1 3 1.4 CS(=O)(=O)CC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL499180 ada1a_human Human No 7.1 EC50 = 84 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
276 3 1 3 1.4 CS(=O)(=O)CC1=CC=CC2=C1CCC2C3=NC=CN3
CHEMBL3601204 ada1a_human Human No 6.1 EC50 = 857 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
419 10 4 7 1.7 CCC1=C2C=CC(=CC2=NN1)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL3601204 ada1a_human Human No 6.1 EC50 = 857 Funct
Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay
419 10 4 7 1.7 CCC1=C2C=CC(=CC2=NN1)OCCNCC(C3=CC(=CC=C3)NS(=O)(=O)C)O
CHEMBL439822 ada1a_human Human No 7.1 EC50 = 87.1 Funct
In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay
260 6 2 4 1.7 CCC(=NOC)C1=CC=CC=C1NCC2=NCCN2
CHEMBL510613 ada1a_human Human No 6.1 EC50 = 879 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
289 3 1 4 2.5 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4CC(C4)(F)F
CHEMBL510613 ada1a_human Human No 6.1 EC50 = 879 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
289 3 1 4 2.5 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4CC(C4)(F)F
CHEMBL508084 ada1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 0 2 1.7 CN1C=C(C=N1)C2=CC=CC=C2C3CC4=NC=CN4C3
CHEMBL326702 ada1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL474796 ada1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
300 3 1 4 2.6 C1CC2=C(C1C3=NC=CN3)C=CC(=C2CN4C=CC(=N4)F)F
CHEMBL508084 ada1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
264 2 0 2 1.7 CN1C=C(C=N1)C2=CC=CC=C2C3CC4=NC=CN4C3
CHEMBL326702 ada1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
265 5 2 4 1.4 CCS(=O)(=O)NC1=CC=CC(=C1)CC2=CN=CN2
CHEMBL474796 ada1a_human Human No 8.1 EC50 = 9 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
300 3 1 4 2.6 C1CC2=C(C1C3=NC=CN3)C=CC(=C2CN4C=CC(=N4)F)F
CHEMBL109783 ada1a_human Human Yes 8.0 EC50 = 9.3 Funct
Effective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptorEffective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptor
309 3 3 5 0.4 CS(=O)(=O)NC1=C(C=CC2=C1CCCC2C3=NCCN3)O
CHEMBL520117 ada1a_human Human No 7.1 EC50 = 90 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
265 3 1 3 1.6 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4C=CN=N4
CHEMBL520117 ada1a_human Human No 7.1 EC50 = 90 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay
265 3 1 3 1.6 C1CC2=C(C1C3=NC=CN3)C=CC=C2CN4C=CN=N4
CHEMBL448147 ada1a_human Human No 7.0 EC50 = 92 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CO4
CHEMBL448147 ada1a_human Human No 7.0 EC50 = 92 Funct
Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
251 2 0 3 1.8 C1C(CN2C1=NC=C2)C3=CC=CC=C3C4=NC=CO4
CHEMBL501920 ada1a_human Human No 6.0 EC50 = 939 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 0 2 1.7 COC1=CC=C(C=C1)C2CC3=NC=CN3C2
CHEMBL501920 ada1a_human Human No 6.0 EC50 = 939 Funct
Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR
214 2 0 2 1.7 COC1=CC=C(C=C1)C2CC3=NC=CN3C2
CHEMBL415 ada1a_rat Rat Yes 10.4 IC50 = 0.0 Funct
Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorCompound was tested for its inhibitory activity against Alpha-1 adrenergic receptor
315 4 0 2 5.2 CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl
CHEMBL445 ada1a_rat Rat Yes 10.4 IC50 = 0.0 Funct
Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorCompound was tested for its inhibitory activity against Alpha-1 adrenergic receptor
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL72 ada1a_rat Rat Yes 9.6 IC50 = 0.3 Funct
Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorCompound was tested for its inhibitory activity against Alpha-1 adrenergic receptor
266 4 1 2 4.9 CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL3810110 ada1a_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3810110 ada1a_human Human No 9.5 IC50 = 0.3 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
444 12 3 6 2.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL304438 ada1a_bovin Bovine No 9.3 IC50 = 0.5 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
381 5 0 5 2.9 CN1C(=O)COC2=C1C=CC(=C2)CCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL3582270 ada1a_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
600 8 1 12 3.3 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)C(=O)N4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL60885 ada1a_bovin Bovine No 9.2 IC50 = 0.6 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
369 5 1 5 3.5 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL3582270 ada1a_human Human No 9.2 IC50 = 0.6 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
600 8 1 12 3.3 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)C(=O)N4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL707 ada1a_rat Rat Yes 9.1 IC50 = 0.7 Funct
Displacement of [3H]-prazosin from rat alpha1A adrenergic receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-prazosin from rat alpha1A adrenergic receptor after 60 mins by scintillation counting analysis
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL64878 ada1a_bovin Bovine No 9.1 IC50 = 0.8 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
398 7 1 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCCCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL85 ada1a_rat Rat Yes 9.0 IC50 = 1.0 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL292935 ada1a_bovin Bovine No 9.0 IC50 = 1 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
384 6 1 5 3.9 COC1=CC=CC=C1N2CCN(CC2)CCCC3=CC4=C(C=C3)NC(=O)S4
CHEMBL25098 ada1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorBinding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptor
540 9 1 6 5.6 CC1=C(OC2=C(C1=O)C=CC=C2C(=O)NCCCN3CCN(CC3)C4=CC=CC=C4OC(C)C)C5=CC=CC=C5
CHEMBL278518 ada1a_rat Rat No 9.0 IC50 = 1 Funct
Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorBinding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptor
530 7 1 5 5.8 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCCNC(=O)C3=CC=CC4=C3OC(=C(C4=O)C)C5=CC=CC=C5
CHEMBL3810145 ada1a_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
528 13 3 8 4.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3810145 ada1a_human Human No 8.9 IC50 = 1.3 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
528 13 3 8 4.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL27341 ada1a_rat Rat No 8.8 IC50 = 1.5 Funct
Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorBinding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptor
497 8 0 6 5.1 CC1=C(OC2=C(C1=O)C=CC=C2C(=O)CCCN3CCN(CC3)C4=CC=CC=C4OC)C5=CC=CC=C5
CHEMBL707 ada1a_rat Rat Yes 8.8 IC50 = 1.6 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL707 ada1a_rat Rat Yes 8.8 IC50 = 1.6 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
451 4 1 9 2.5 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC
CHEMBL1108 ada1a_rat Rat Yes 8.8 IC50 = 1.7 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL1108 ada1a_rat Rat Yes 8.8 IC50 = 1.7 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
379 6 1 4 3.5 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CCCC(=O)C4=CC=C(C=C4)F
CHEMBL11 ada1a_rat Rat Yes 8.8 IC50 = 1.7 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
280 4 0 2 4.8 CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL3809490 ada1a_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809248 ada1a_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 13 3 5 2.8 CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808572 ada1a_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 13 3 8 3.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL3809490 ada1a_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809248 ada1a_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 13 3 5 2.8 CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808572 ada1a_human Human No 8.7 IC50 = 1.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
494 13 3 8 3.5 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL85 ada1a_human Human Yes 8.0 IC50 = 10 Funct
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL85 ada1a_human Human Yes 8.0 IC50 = 10 Funct
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL293923 ada1a_bovin Bovine No 8.0 IC50 = 10 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
384 5 0 5 3.7 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC=C4OC)SC1=O
CHEMBL85 ada1a_human Human Yes 8.0 IC50 = 10 Funct
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL24629 ada1a_rat Rat No 8.0 IC50 = 10 Funct
Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorBinding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptor
499 9 0 6 5.8 CC1=C(OC2=C(C1=O)C=CC=C2OCCCCN3CCN(CC3)C4=CC=CC=C4OC)C5=CC=CC=C5
CHEMBL85 ada1a_human Human Yes 8.0 IC50 = 10.9 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL113830 ada1a_human Human Yes 7.0 IC50 = 100 Funct
Inhibition of Alpha-1 adrenergic receptorInhibition of Alpha-1 adrenergic receptor
325 5 2 3 3.9 CC(C(C1=CC=C(C=C1)O)O)N2CCC(CC2)CC3=CC=CC=C3
CHEMBL420644 ada1a_rat Rat No 7.0 IC50 = 100 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
282 4 1 2 3.6 CN(C)CC(C1=CC=C(C=C1)Cl)C2(CCCCC2)O
CHEMBL511747 ada1a_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
498 7 0 6 2.9 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5CCCC5=O
CHEMBL143617 ada1a_rat Rat Yes 6.0 IC50 = 1000 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
433 5 1 3 4.0 CC1=CC2=C(C=C1)N(C(=C2C3=CC=C(C=C3)F)C)C4=CCN(CC4)CCN5CCNC5=O
CHEMBL511747 ada1a_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
498 7 0 6 2.9 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5CCCC5=O
CHEMBL508712 ada1a_human Human No 5.0 IC50 = 10000 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
404 4 0 4 4.4 CC1=CC=CC2=C1N=C(N(C2=O)C)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL27763 ada1a_bovin Bovine No 5.0 IC50 = 10000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
429 8 1 5 4.3 CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C3CC4=C(C=CC=C4O)OC3
CHEMBL284912 ada1a_bovin Bovine No 5.0 IC50 = 10000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
363 9 0 5 3.3 CCCN(CCCCN1CCOCC1)C2CC3=C(C=CC=C3OC)OC2
CHEMBL508712 ada1a_human Human No 5.0 IC50 = 10000 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
404 4 0 4 4.4 CC1=CC=CC2=C1N=C(N(C2=O)C)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL27995 ada1a_bovin Bovine Yes 4.0 IC50 = 100000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
249 5 1 3 3.5 CCCN(CCC)C1CC2=C(C=CC=C2O)OC1
CHEMBL280608 ada1a_bovin Bovine No 4.0 IC50 = 100000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
419 9 1 6 3.9 CCCN(CCNS(=O)(=O)C1=CC=C(C=C1)C)C2CC3=C(C=CC=C3OC)OC2
CHEMBL51888 ada1a_bovin Bovine No 4.0 IC50 = 100000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
419 9 1 6 3.9 CCCN(CCNS(=O)(=O)C1=CC=C(C=C1)C)C2CC3=C(C=CC=C3OC)OC2
CHEMBL97044 ada1a_human Human No 6.0 IC50 = 1047.1 Funct
Concentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in humanConcentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in human
258 5 3 3 1.3 C1CC1NC(=O)C2=CC=CC=C2NCC3=NCCN3
CHEMBL117248 ada1a_human Human No 7.0 IC50 = 107.2 Funct
In vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblasts
221 4 2 3 1.4 CSC1=CC=CC=C1NCC2=NCCN2
CHEMBL30008 ada1a_rat Rat Yes 6.0 IC50 = 1088 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL30008 ada1a_rat Rat Yes 6.0 IC50 = 1088 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
405 6 0 4 6.0 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL1403281 ada1a_rat Rat Yes 8.0 IC50 = 11 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL1403281 ada1a_rat Rat Yes 8.0 IC50 = 11 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
576 5 3 6 2.7 CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=CNC7=CC=CC(=C67)C5=C4)C)O
CHEMBL422130 ada1a_rat Rat Yes 8.0 IC50 = 11 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
441 5 1 3 3.9 C1CN(CCC1N2C=C(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL332913 ada1a_rat Rat No 7.0 IC50 = 110 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
375 5 0 4 4.0 C1COCCN1CCOC2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F
CHEMBL488251 ada1a_human Human No 6.0 IC50 = 1100 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
406 7 0 4 4.5 CC(C)N1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL488251 ada1a_human Human No 6.0 IC50 = 1100 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
406 7 0 4 4.5 CC(C)N1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL165796 ada1a_human Human No 7.0 IC50 = 112.2 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
373 3 0 4 2.7 CC1=CC2=NC(=C(C(=O)N2C=C1)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C
CHEMBL162490 ada1a_human Human No 6.9 IC50 = 114.8 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
389 4 0 5 3.0 CC1=C(C(=O)N2C=CC=C(C2=N1)OC)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL420683 ada1a_human Human No 6.9 IC50 = 114.8 Funct
Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptorBinding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptor
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=N3
CHEMBL467668 ada1a_human Human No 5.9 IC50 = 1160 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
484 7 0 6 3.8 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5CCCC5
CHEMBL467668 ada1a_human Human No 5.9 IC50 = 1160 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
484 7 0 6 3.8 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5CCCC5
CHEMBL621 ada1a_rat Rat Yes 6.9 IC50 = 117 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
372 5 0 4 2.8 C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl
CHEMBL421239 ada1a_rat Rat No 7.9 IC50 = 12 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
445 9 1 4 3.9 CCN(CCN1CCNC1=O)CCOC2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F
CHEMBL3805518 ada1a_human Human No 6.9 IC50 = 120 Funct
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
443 8 1 7 4.2 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)F
CHEMBL1358628 ada1a_rat Rat Yes 6.9 IC50 = 120 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL1729 ada1a_rat Rat Yes 6.9 IC50 = 120 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL74656 ada1a_rat Rat Yes 6.9 IC50 = 120 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
466 9 2 7 3.4 COC1CN(CCC1NC(=O)C2=CC(=C(C=C2OC)N)Cl)CCCOC3=CC=C(C=C3)F
CHEMBL3805518 ada1a_human Human No 6.9 IC50 = 120 Funct
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
443 8 1 7 4.2 CNC(=O)C1=C(C=CC(=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)F
CHEMBL3739900 ada1a_human Human No 5.9 IC50 = 1200 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 7 0 4 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)CC5=CC=CC=C5
CHEMBL3739900 ada1a_human Human No 5.9 IC50 = 1200 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 7 0 4 4.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)CC5=CC=CC=C5
CHEMBL8412 ada1a_bovin Bovine Yes 5.9 IC50 = 1200 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
401 6 0 7 1.5 C1CN(CCN1CCCCN2C(=O)C3=CC=CC=C3S2(=O)=O)C4=NC=CC=N4
CHEMBL55 ada1a_rat Rat Yes 5.9 IC50 = 1212 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL55 ada1a_rat Rat Yes 5.9 IC50 = 1212 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
340 10 4 4 2.6 C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N
CHEMBL100774 ada1a_rat Rat No 6.9 IC50 = 126 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
263 5 1 3 2.4 CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCC2)O
CHEMBL3740874 ada1a_human Human No 6.9 IC50 = 128 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
469 6 0 6 4.1 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)C#N)F
CHEMBL3740874 ada1a_human Human No 6.9 IC50 = 128 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
469 6 0 6 4.1 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=C(C=C(C=C5)C#N)F
CHEMBL344294 ada1a_human Human No 5.9 IC50 = 1288.3 Funct
Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptorBinding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptor
267 4 1 3 1.9 CC1=CC(=NC=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL454246 ada1a_human Human No 7.9 IC50 = 13 Funct
Inhibition of adrenergic receptor 1a expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetryInhibition of adrenergic receptor 1a expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetry
795 6 5 13 3.8 CC1CC2C34C(C5C6(C(C3C7C(O7)(C(C2(C1OC(=O)C=CC=CC(C8CCC(C8C)CC6(C)O)OC(=O)CC(C)C)O)O)CO)OC(O5)(O4)C9=CC=CC=C9)O)C
CHEMBL123640 ada1a_rat Rat No 6.9 IC50 = 130 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
317 4 0 2 4.7 CN(C)CCC1=CN(C2=C1C=CC(=C2)Cl)C3=CC=C(C=C3)F
CHEMBL72 ada1a_rat Rat Yes 6.9 IC50 = 130 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
266 4 1 2 4.9 CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL101899 ada1a_rat Rat Yes 6.9 IC50 = 130 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
282 4 1 2 3.6 CN(C)CC(C1=CC(=CC=C1)Cl)C2(CCCCC2)O
CHEMBL519067 ada1a_human Human No 5.9 IC50 = 1300 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
392 7 0 4 4.1 CCN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL519067 ada1a_human Human No 5.9 IC50 = 1300 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
392 7 0 4 4.1 CCN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL583014 ada1a_human Human No 5.9 IC50 = 1320 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
489 5 2 11 5.5 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N(C)C
CHEMBL583014 ada1a_human Human No 5.9 IC50 = 1320 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
489 5 2 11 5.5 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N(C)C
CHEMBL1306 ada1a_rat Rat Yes 4.9 IC50 = 13278 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL1306 ada1a_rat Rat Yes 4.9 IC50 = 13278 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
532 8 0 7 4.8 CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL862 ada1a_rat Rat Yes 5.9 IC50 = 1348 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
246 2 2 1 2.0 C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
CHEMBL862 ada1a_rat Rat Yes 5.9 IC50 = 1348 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
246 2 2 1 2.0 C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
CHEMBL122269 ada1a_rat Rat No 7.9 IC50 = 14 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
415 7 1 3 3.8 CN(CCC1=CN(C2=C1C=CC(=C2)Cl)C3=CC=C(C=C3)F)CCN4CCNC4=O
CHEMBL341229 ada1a_rat Rat No 7.9 IC50 = 14 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
429 8 1 3 4.1 CN(CCCN1CCNC1=O)CCC2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F
CHEMBL25012 ada1a_rat Rat No 7.9 IC50 = 14 Funct
Binding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptorBinding affinity was tested on CEC-pretreated rat hippocampus Alpha-1A adrenergic receptor
498 7 1 6 4.4 CC1=C(OC2=C(C1=O)C=CC=C2C(=O)NCCN3CCN(CC3)C4=CC=CC=C4OC)C5=CC=CC=C5
CHEMBL3740558 ada1a_human Human No 7.9 IC50 = 14.3 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
468 7 0 5 4.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740558 ada1a_human Human No 7.9 IC50 = 14.3 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
468 7 0 5 4.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3808878 ada1a_human Human No 7.8 IC50 = 14.4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
412 11 3 5 2.9 CC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3808878 ada1a_human Human No 7.8 IC50 = 14.4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
412 11 3 5 2.9 CC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL315772 ada1a_human Human No 7.8 IC50 = 14.5 Funct
Binding affinity against Alpha-1A adrenergic receptorBinding affinity against Alpha-1A adrenergic receptor
329 2 0 3 4.5 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)Cl
CHEMBL315772 ada1a_human Human No 7.8 IC50 = 14.5 Funct
Binding affinity for human cloned Alpha-1A adrenergic receptorBinding affinity for human cloned Alpha-1A adrenergic receptor
329 2 0 3 4.5 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)Cl
CHEMBL637 ada1a_rat Rat Yes 6.9 IC50 = 140 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
277 5 1 3 2.9 CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCC2)O
CHEMBL395110 ada1a_rat Rat Yes 6.8 IC50 = 144 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL395110 ada1a_rat Rat Yes 6.8 IC50 = 144 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
310 2 0 3 5.6 CN1CCCC(C1)CN2C3=CC=CC=C3SC4=CC=CC=C42
CHEMBL122113 ada1a_rat Rat No 7.8 IC50 = 15 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
415 7 1 3 3.8 CN(CCC1=CN(C2=C1C=C(C=C2)Cl)C3=CC=C(C=C3)F)CCN4CCNC4=O
CHEMBL3742198 ada1a_human Human No 7.8 IC50 = 15.2 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5Cl
CHEMBL3742198 ada1a_human Human No 7.8 IC50 = 15.2 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5Cl
CHEMBL3810401 ada1a_human Human No 7.8 IC50 = 15.4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
460 12 3 5 3.0 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL3810401 ada1a_human Human No 7.8 IC50 = 15.4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
460 12 3 5 3.0 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Cl)OC
CHEMBL123584 ada1a_rat Rat No 6.8 IC50 = 150 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
388 5 0 4 4.2 CN1CCN(CC1)CCOC2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F
CHEMBL101055 ada1a_rat Rat No 6.8 IC50 = 150 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
277 5 1 3 2.9 CN(C)CC(C1=CC(=CC=C1)OC)C2(CCCCC2)O
CHEMBL3741658 ada1a_human Human No 6.8 IC50 = 151.3 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
426 6 0 4 4.3 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5
CHEMBL3741658 ada1a_human Human No 6.8 IC50 = 151.3 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
426 6 0 4 4.3 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5
CHEMBL2106399 ada1a_rat Rat Yes 5.8 IC50 = 1544 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
786 12 4 15 2.4 CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O
CHEMBL2106399 ada1a_rat Rat Yes 5.8 IC50 = 1544 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
786 12 4 15 2.4 CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)O)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O
CHEMBL42 ada1a_bovin Bovine Yes 6.8 IC50 = 160 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL49 ada1a_bovin Bovine Yes 4.8 IC50 = 16000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL314107 ada1a_human Human No 6.8 IC50 = 162.2 Funct
Binding affinity for human cloned Alpha-1A adrenergic receptorBinding affinity for human cloned Alpha-1A adrenergic receptor
330 2 0 5 4.1 CN(C)CC1CC2C3=C(CC4=C(N2O1)C=C(C=C4)F)C=CC(=C3)F
CHEMBL122621 ada1a_rat Rat No 4.8 IC50 = 16218.1 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat
591 27 4 8 5.0 COC1=CC=CC(=C1)CNCCCCCCNCCSSCCNCCCCCCNCC2=CC=CC=C2OC
CHEMBL118055 ada1a_human Human Yes 6.8 IC50 = 169.8 Funct
In vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblasts
219 4 2 3 2.1 CSC1=CC=CC=C1NCC2=CN=CN2
CHEMBL125483 ada1a_rat Rat No 7.8 IC50 = 17 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
333 5 0 3 4.4 CN(C)CCOC1=CN(C2=C1C=C(C=C2)Cl)C3=CC=C(C=C3)F
CHEMBL3808717 ada1a_human Human No 7.8 IC50 = 17.1 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
522 14 3 8 4.3 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808717 ada1a_human Human No 7.8 IC50 = 17.1 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
522 14 3 8 4.3 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL430717 ada1a_bovin Bovine No 7.8 IC50 = 17.2 Funct
Binding affinity was tested on cloned bovine Alpha-1A adrenergic receptorBinding affinity was tested on cloned bovine Alpha-1A adrenergic receptor
496 8 1 9 3.8 CC(C)C1=C(C(=CC=C1)OC)OCC(=O)N2CCN(CC2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL339919 ada1a_rat Rat No 6.8 IC50 = 170 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
333 5 0 3 4.4 CN(C)CCOC1=CN(C2=C1C=CC(=C2)Cl)C3=CC=C(C=C3)F
CHEMBL19376 ada1a_human Human No 5.8 IC50 = 1700 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtype.Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtype.
388 5 3 8 1.3 CC(C)(C)NC(=O)C1CN(CCN1)C2=NC3=CC(=C(C=C3C(=N2)N)OC)OC
CHEMBL549 ada1a_rat Rat Yes 5.8 IC50 = 1756 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
324 5 0 4 3.2 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL549 ada1a_rat Rat Yes 5.8 IC50 = 1756 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
324 5 0 4 3.2 CN(C)CCCC1(C2=C(CO1)C=C(C=C2)C#N)C3=CC=C(C=C3)F
CHEMBL301956 ada1a_rat Rat No 7.8 IC50 = 18 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
303 3 0 2 4.2 CN(C)CC1=CN(C2=C1C=C(C=C2)Cl)C3=CC=C(C=C3)F
CHEMBL487230 ada1a_human Human No 5.8 IC50 = 1800 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
406 8 0 4 4.6 CCCN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL487230 ada1a_human Human No 5.8 IC50 = 1800 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
406 8 0 4 4.6 CCCN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL144318 ada1a_rat Rat Yes 7.7 IC50 = 19 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
424 5 1 4 3.4 C1CN(CCC1N2C=C(C3=C2C=CC(=C3)F)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL355917 ada1a_rat Rat Yes 6.7 IC50 = 190 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
475 5 1 6 4.2 C1CN(CCC1N2C=C(C3=C2C=CC(=C3)C(F)(F)F)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL344335 ada1a_rat Rat No 6.7 IC50 = 190 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
322 2 0 2 4.6 CC1=CC2=C(C=C1)N(C=C2C3=CC=C(C=C3)F)C4CCN(CC4)C
CHEMBL99503 ada1a_rat Rat No 6.7 IC50 = 190 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
356 5 1 3 3.6 CN(C)CC(C1=CC(=C(C=C1)OC)Br)C2(CCCCC2)O
CHEMBL81485 ada1a_human Human No 6.7 IC50 = 190.6 Funct
Binding affinity for human cloned Alpha-1A adrenergic receptorBinding affinity for human cloned Alpha-1A adrenergic receptor
280 2 1 3 3.4 CNCC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL154023 ada1a_human Human No 6.7 IC50 = 190.6 Funct
In vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cellsIn vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cells
256 4 2 4 1.4 CC1=C(OC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL156661 ada1a_human Human No 6.7 IC50 = 190.6 Funct
In vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cellsIn vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cells
253 4 2 4 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CC=N3
CHEMBL19826 ada1a_human Human No 5.7 IC50 = 1900 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtypeCompound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtype
483 6 2 9 2.4 CC(C)(C)NC(=O)C1CN(CCN1C(=O)C2=CC=CO2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL2203713 ada1a_human Human No 5.7 IC50 = 1900 Funct
Inhibition of alpha1A adrenergic receptorInhibition of alpha1A adrenergic receptor
326 3 2 4 2.9 C1CNCCC1N2CCC3=C2C=CC(=C3)N=C(C4=CC=CS4)N
CHEMBL313189 ada1a_human Human No 5.7 IC50 = 1905.5 Funct
Binding affinity for human cloned Alpha-1A adrenergic receptorBinding affinity for human cloned Alpha-1A adrenergic receptor
308 3 0 3 4.2 CN(C)CCC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL494155 ada1a_human Human No 5.7 IC50 = 1910 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
482 7 0 7 3.2 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=NC=N5
CHEMBL494156 ada1a_human Human No 5.7 IC50 = 1910 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
483 7 0 8 2.7 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=NN=N5
CHEMBL494155 ada1a_human Human No 5.7 IC50 = 1910 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
482 7 0 7 3.2 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=NC=N5
CHEMBL494156 ada1a_human Human No 5.7 IC50 = 1910 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
483 7 0 8 2.7 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=NN=N5
CHEMBL43064 ada1a_rat Rat Yes 5.7 IC50 = 1919 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL43064 ada1a_rat Rat Yes 5.7 IC50 = 1919 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
369 6 0 2 5.8 C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL493967 ada1a_human Human No 5.7 IC50 = 1920 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
482 7 0 7 2.9 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=CN=N5
CHEMBL493967 ada1a_human Human No 5.7 IC50 = 1920 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
482 7 0 7 2.9 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=CN=N5
CHEMBL411 ada1a_rat Rat Yes 4.7 IC50 = 19487 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL411 ada1a_rat Rat Yes 4.7 IC50 = 19487 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
268 4 2 2 5.1 CCC(=C(CC)C1=CC=C(C=C1)O)C2=CC=C(C=C2)O
CHEMBL17851 ada1a_human Human No 6.7 IC50 = 199.5 Funct
Inhibitory concentration against radioligand binding to human Alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human Alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells
255 4 2 3 0.9 CN1C(=CC=N1)C2=CC=CC=C2NCC3=NCCN3
CHEMBL384790 ada1a_rat Rat No 5.7 IC50 = 1995.3 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=C(C=C4)CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=C(C=C5)C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL3740019 ada1a_human Human No 8.7 IC50 = 2.0 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740019 ada1a_human Human No 8.7 IC50 = 2.0 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=C(C=C1)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3809840 ada1a_human Human No 8.7 IC50 = 2.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809840 ada1a_human Human No 8.7 IC50 = 2.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3582269 ada1a_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
545 5 2 12 2.1 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CN(N=N4)C5=CC6=C(C=C(C=C6)O)OC5=O)N)OC
CHEMBL3582269 ada1a_human Human No 8.6 IC50 = 2.5 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
545 5 2 12 2.1 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CN(N=N4)C5=CC6=C(C=C(C=C6)O)OC5=O)N)OC
CHEMBL3808726 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
574 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Br)OCC(F)(F)F
CHEMBL3810346 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3809093 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
502 14 3 5 3.9 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL3808511 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
492 11 3 5 3.2 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL3808726 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
574 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Br)OCC(F)(F)F
CHEMBL3810346 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3809093 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
502 14 3 5 3.9 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OCC4=CC=CC=C4
CHEMBL3808511 ada1a_human Human No 8.6 IC50 = 2.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
492 11 3 5 3.2 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)F)Br
CHEMBL3808896 ada1a_human Human No 8.5 IC50 = 2.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3809175 ada1a_human Human No 8.5 IC50 = 2.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
506 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3808896 ada1a_human Human No 8.5 IC50 = 2.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)F)OC
CHEMBL3809175 ada1a_human Human No 8.5 IC50 = 2.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
506 12 3 6 3.2 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL59823 ada1a_bovin Bovine No 7.7 IC50 = 20 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
410 7 0 5 3.6 CN1C(=O)COC2=C1C=CC(=C2)CCCCN3CCN(CC3)C4=CC=CC=C4OC
CHEMBL54 ada1a_bovin Bovine Yes 7.7 IC50 = 20 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
376 6 1 4 3.2 C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F
CHEMBL3808999 ada1a_human Human No 7.7 IC50 = 20.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
424 12 3 4 3.2 CCC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3808999 ada1a_human Human No 7.7 IC50 = 20.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
424 12 3 4 3.2 CCC1=CC=CC=C1OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL61818 ada1a_bovin Bovine No 6.7 IC50 = 200 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
450 6 0 7 5.4 CN1C2=C(C=C(C=C2)CCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F)SC1=O
CHEMBL27991 ada1a_bovin Bovine No 5.7 IC50 = 2000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
415 10 1 5 4.7 CCCN(CCCCNC(=O)C1=CC=C(C=C1)F)C2CC3=C(C=CC=C3OC)OC2
CHEMBL298534 ada1a_bovin Bovine No 5.7 IC50 = 2000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
415 10 1 5 4.7 CCCN(CCCCNC(=O)C1=CC=C(C=C1)F)C2CC3=C(C=CC=C3OC)OC2
CHEMBL52438 ada1a_bovin Bovine No 5.7 IC50 = 2000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
283 5 0 2 5.1 CCCN(CCC)C1CC2=C(C=CC3=CC=CC=C23)OC1
CHEMBL19826 ada1a_rat Rat No 5.7 IC50 = 2000 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat prostate Alpha-1A adrenergic receptor subtypeCompound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat prostate Alpha-1A adrenergic receptor subtype
483 6 2 9 2.4 CC(C)(C)NC(=O)C1CN(CCN1C(=O)C2=CC=CO2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL162436 ada1a_human Human No 6.7 IC50 = 204.2 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
436 5 0 4 4.3 C1CN(CC2=C1OC3=CC=CC=C23)CCC4=C(N=C5C=CC=CN5C4=O)CC6=CC=CC=C6
CHEMBL450018 ada1a_human Human No 5.7 IC50 = 2041.7 Funct
Concentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in humanConcentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in human
260 5 2 3 1.3 CCN(C)C(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL99670 ada1a_rat Rat No 6.7 IC50 = 205 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
261 4 1 2 3.3 CC1=CC=C(C=C1)C(CN(C)C)C2(CCCCC2)O
CHEMBL6966 ada1a_rat Rat Yes 5.7 IC50 = 2092 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
455 13 0 6 3.8 CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
CHEMBL6966 ada1a_rat Rat Yes 5.7 IC50 = 2092 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
455 13 0 6 3.8 CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC
CHEMBL3809532 ada1a_human Human No 7.7 IC50 = 21.8 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 11 3 5 3.3 CC1=C(C(=CC=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3809532 ada1a_human Human No 7.7 IC50 = 21.8 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 11 3 5 3.3 CC1=C(C(=CC=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL808 ada1a_rat Rat Yes 4.7 IC50 = 21160 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
382 6 0 2 5.3 C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
CHEMBL165181 ada1a_human Human No 6.7 IC50 = 213.8 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
375 3 0 4 3.4 CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC4=C(C3)C5=CC=CC=C5S4
CHEMBL95523 ada1a_human Human No 6.7 IC50 = 213.8 Funct
Concentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in humanConcentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in human
232 4 3 3 0.8 CNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL488248 ada1a_human Human No 5.7 IC50 = 2200 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
363 6 0 4 3.4 CN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCC4
CHEMBL488248 ada1a_human Human No 5.7 IC50 = 2200 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
363 6 0 4 3.4 CN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCC4
CHEMBL81 ada1a_rat Rat Yes 5.7 IC50 = 2204 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL81 ada1a_rat Rat Yes 5.7 IC50 = 2204 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
474 7 2 6 6.1 C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
CHEMBL83 ada1a_rat Rat Yes 4.7 IC50 = 22050 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
372 8 0 2 7.1 CCC(=C(C1=CC=CC=C1)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3
CHEMBL319553 ada1a_human Human No 6.7 IC50 = 223.9 Funct
Concentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in humanConcentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in human
261 6 2 4 2.1 CC(C)OC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL3740042 ada1a_human Human No 6.6 IC50 = 227.7 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740042 ada1a_human Human No 6.6 IC50 = 227.7 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
440 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740847 ada1a_human Human No 6.6 IC50 = 229.4 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)F
CHEMBL3740847 ada1a_human Human No 6.6 IC50 = 229.4 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
444 6 0 5 4.4 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)F
CHEMBL122018 ada1a_rat Rat No 7.6 IC50 = 23 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
401 6 1 3 3.3 CN(CCN1CCNC1=O)CC2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F
CHEMBL144901 ada1a_rat Rat No 7.6 IC50 = 23 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
421 5 1 3 3.7 CC1=CC=CC2=C1N(C=C2C3=CC=C(C=C3)F)C4CCN(CC4)CCN5CCNC5=O
CHEMBL522037 ada1a_human Human No 6.6 IC50 = 230 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
504 6 0 4 6.6 CC1=CC=C(C=C1)N(C2=CC(=C(C=C2)F)F)C(=O)N(C)CCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL522037 ada1a_human Human No 6.6 IC50 = 230 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
504 6 0 4 6.6 CC1=CC=C(C=C1)N(C2=CC(=C(C=C2)F)F)C(=O)N(C)CCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL343444 ada1a_rat Rat Yes 5.6 IC50 = 2300 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
435 5 1 3 4.1 CC1=CC2=C(C=C1)N(C(=C2C3=CC=C(C=C3)F)C)C4CCN(CC4)CCN5CCNC5=O
CHEMBL162232 ada1a_human Human No 6.6 IC50 = 239.9 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
387 3 0 4 3.1 CC1=CC2=NC(=C(C(=O)N2C(=C1)C)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C
CHEMBL296419 ada1a_rat Rat Yes 7.6 IC50 = 24 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL611 ada1a_rat Rat Yes 7.6 IC50 = 24 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL296419 ada1a_rat Rat Yes 7.6 IC50 = 24 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
459 8 1 5 6.0 COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
CHEMBL611 ada1a_rat Rat Yes 7.6 IC50 = 24 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
387 4 1 8 1.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4CCCO4)N)OC
CHEMBL343034 ada1a_rat Rat Yes 7.6 IC50 = 24 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
419 5 1 3 3.6 CC1=CC2=C(C=C1)N(C=C2C3=CC=C(C=C3)F)C4=CCN(CC4)CCN5CCNC5=O
CHEMBL487060 ada1a_human Human No 5.6 IC50 = 2400 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
440 7 0 4 5.3 C1CCN(CC1)CCCOC2=CC=C(C=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL487060 ada1a_human Human No 5.6 IC50 = 2400 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
440 7 0 4 5.3 C1CCN(CC1)CCCOC2=CC=C(C=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL162826 ada1a_human Human No 6.6 IC50 = 245.5 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
375 3 1 5 2.6 CC1=C(C(=O)N2C=CC=C(C2=N1)O)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL1631540 ada1a_rat Rat Yes 7.6 IC50 = 25.1 Funct
Inhibition of rat adrenergic alpha1A receptorInhibition of rat adrenergic alpha1A receptor
416 5 1 4 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCNC5=O
CHEMBL1631540 ada1a_rat Rat Yes 7.6 IC50 = 25.1 Funct
Inhibition of rat adrenergic alpha1A receptorInhibition of rat adrenergic alpha1A receptor
416 5 1 4 3.4 CC1=NC2=C(C=C1)C(=CC=C2)N3CCN(CC3)CCC4=CC(=CC=C4)N5CCNC5=O
CHEMBL277375 ada1a_human Human No 7.6 IC50 = 25.1 Funct
Inhibitory concentration against radioligand binding to human Alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cellsInhibitory concentration against radioligand binding to human Alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells
241 4 3 3 0.9 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NN3
CHEMBL3810198 ada1a_human Human No 7.6 IC50 = 25.6 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 3.4 CCC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3810198 ada1a_human Human No 7.6 IC50 = 25.6 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 3.4 CCC1=CC=CC=C1OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL163247 ada1a_human Human No 5.6 IC50 = 2570.4 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
428 3 0 4 4.0 CC1=C(C(=O)N2C=C(C=C(C2=N1)Cl)Cl)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL321364 ada1a_rat Rat No 6.6 IC50 = 260 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
326 4 1 2 3.6 CN(C)CC(C1=CC=CC=C1Br)C2(CCCCC2)O
CHEMBL305660 ada1a_rat Rat Yes 5.6 IC50 = 2605.4 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL305660 ada1a_rat Rat Yes 5.6 IC50 = 2605.4 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
470 10 0 3 7.2 CC(C)(C)C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
CHEMBL104 ada1a_rat Rat Yes 4.6 IC50 = 26343 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
345 4 0 1 5.0 C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4
CHEMBL141667 ada1a_rat Rat No 7.6 IC50 = 27 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
419 5 1 3 3.6 CC1=CC=CC2=C1N(C=C2C3=CC=C(C=C3)F)C4=CCN(CC4)CCN5CCNC5=O
CHEMBL13789 ada1a_human Human No 7.6 IC50 = 27.5 Funct
Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptorBinding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptor
252 4 1 2 2.5 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CC=C3
CHEMBL3809781 ada1a_human Human No 7.6 IC50 = 27.8 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 11 3 7 2.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC4=C(C=C3)OCO4
CHEMBL3809781 ada1a_human Human No 7.6 IC50 = 27.8 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
442 11 3 7 2.4 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC4=C(C=C3)OCO4
CHEMBL144362 ada1a_rat Rat Yes 5.6 IC50 = 2700 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
336 2 0 2 5.0 CC1=CC2=C(C=C1)N(C(=C2C3=CC=C(C=C3)F)C)C4CCN(CC4)C
CHEMBL95 ada1a_rat Rat Yes 5.6 IC50 = 2749 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
198 0 1 2 2.7 C1CCC2=NC3=CC=CC=C3C(=C2C1)N
CHEMBL567993 ada1a_human Human No 5.6 IC50 = 2790 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
367 5 2 5 4.0 CC1=CC=CC(=C1)C(=O)NC2CCC(CC2)NC3=NC=C(C(=N3)N(C)C)C
CHEMBL567993 ada1a_human Human No 5.6 IC50 = 2790 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
367 5 2 5 4.0 CC1=CC=CC(=C1)C(=O)NC2CCC(CC2)NC3=NC=C(C(=N3)N(C)C)C
CHEMBL145712 ada1a_rat Rat Yes 6.6 IC50 = 280 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
463 6 0 3 4.7 CC1=CC2=C(C=C1)N(C=C2C3=CC=C(C=C3)F)C4CCN(CC4)CCN5CCN(C5=O)C(C)C
CHEMBL164612 ada1a_human Human No 6.6 IC50 = 281.8 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
394 3 0 4 3.4 CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC4=C(C3)C5=C(O4)C(=CC=C5)Cl
CHEMBL318544 ada1a_human Human No 6.6 IC50 = 281.8 Funct
In vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblasts
260 6 3 3 1.7 CCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL351542 ada1a_human Human No 6.6 IC50 = 281.8 Funct
In vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cellsIn vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cells
232 5 2 4 1.0 CON=CC1=CC=CC=C1NCC2=NCCN2
CHEMBL219916 ada1a_rat Rat Yes 6.5 IC50 = 285 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
426 5 2 3 3.9 C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
CHEMBL162370 ada1a_human Human No 6.5 IC50 = 288.4 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
373 3 0 4 2.7 CC1=CN2C(=NC(=C(C2=O)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C)C=C1
CHEMBL487064 ada1a_human Human No 5.5 IC50 = 2900 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
377 6 0 4 3.7 CN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL487064 ada1a_human Human No 5.5 IC50 = 2900 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
377 6 0 4 3.7 CN1C(=NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)OCCCN4CCCCC4
CHEMBL3810005 ada1a_human Human No 8.5 IC50 = 3.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3187195 ada1a_human Human Yes 8.5 IC50 = 3.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
496 13 3 9 3.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL3810005 ada1a_human Human No 8.5 IC50 = 3.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
530 13 3 9 4.3 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=CC(=C3)Cl)OCC(F)(F)F
CHEMBL3187195 ada1a_human Human Yes 8.5 IC50 = 3.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
496 13 3 9 3.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OCC(F)(F)F
CHEMBL12713 ada1a_rat Rat Yes 8.5 IC50 = 3.4 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
441 5 1 3 4.1 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL12713 ada1a_rat Rat Yes 8.5 IC50 = 3.4 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
441 5 1 3 4.1 C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL3809794 ada1a_human Human No 8.4 IC50 = 3.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 12 3 5 3.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3809794 ada1a_human Human No 8.4 IC50 = 3.7 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
504 12 3 5 3.1 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=C(C=C(C=C3)Br)OC
CHEMBL3582268 ada1a_human Human No 8.4 IC50 = 3.9 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
477 4 2 10 2.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC5=C(C=C(C=C5)O)OC4=O)N)OC
CHEMBL3582268 ada1a_human Human No 8.4 IC50 = 3.9 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
477 4 2 10 2.4 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC5=C(C=C(C=C5)O)OC4=O)N)OC
CHEMBL64610 ada1a_bovin Bovine No 7.5 IC50 = 30 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
448 6 0 7 4.5 CN1C(=O)COC2=C1C=CC(=C2)CCCCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL60318 ada1a_bovin Bovine No 7.5 IC50 = 30 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
371 4 0 5 3.9 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=C(C=C4)F)SC1=O
CHEMBL61819 ada1a_bovin Bovine No 7.5 IC50 = 30 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
412 7 0 5 4.4 CN1C2=C(C=C(C=C2)CCCCN3CCN(CC3)C4=CC=CC=C4OC)SC1=O
CHEMBL3741318 ada1a_human Human No 7.5 IC50 = 30.1 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3741318 ada1a_human Human No 7.5 IC50 = 30.1 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
456 7 0 5 4.3 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL182150 ada1a_human Human Yes 6.5 IC50 = 300 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
425 5 2 7 4.8 CN(C)C1=NC(=NC2=CC=CC=C21)NC3CCC(CC3)NC(=O)C4=CC(=C(C=C4)F)F
CHEMBL182150 ada1a_human Human Yes 6.5 IC50 = 300 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
425 5 2 7 4.8 CN(C)C1=NC(=NC2=CC=CC=C21)NC3CCC(CC3)NC(=O)C4=CC(=C(C=C4)F)F
CHEMBL101056 ada1a_rat Rat No 6.5 IC50 = 300 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
291 5 1 3 3.5 CN(C)CC(C1=CC=C(C=C1)OC)C2(CCCCCC2)O
CHEMBL98660 ada1a_rat Rat No 6.5 IC50 = 300 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
247 4 1 2 3.0 CN(C)CC(C1=CC=CC=C1)C2(CCCCC2)O
CHEMBL567791 ada1a_human Human No 5.5 IC50 = 3000 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
388 5 2 5 4.3 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)Cl)N(C)C
CHEMBL28312 ada1a_bovin Bovine No 5.5 IC50 = 3000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
427 11 1 5 4.6 CCCN(CCCCNC(=O)C1=CC=CC=C1OC)C2CC3=C(C=CC=C3OC)OC2
CHEMBL48925 ada1a_bovin Bovine No 5.5 IC50 = 3000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
427 11 1 5 4.6 CCCN(CCCCNC(=O)C1=CC=CC=C1OC)C2CC3=C(C=CC=C3OC)OC2
CHEMBL567791 ada1a_human Human No 5.5 IC50 = 3000 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
388 5 2 5 4.3 CC1=CC(=NC(=N1)NC2CCC(CC2)NC(=O)C3=CC=C(C=C3)Cl)N(C)C
CHEMBL56 ada1a_bovin Bovine Yes 4.5 IC50 = 30000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
247 5 1 2 4.1 CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O
CHEMBL116700 ada1a_human Human No 6.5 IC50 = 302 Funct
In vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblastsIn vitro binding affinity against cloned human alpha-1A-adrenoceptor receptors expressed in rat-1 fibroblasts
250 4 1 2 3.2 C1=CC=C(C=C1)C2=CC=CC=C2OCC3=CN=CN3
CHEMBL445 ada1a_rat Rat Yes 6.5 IC50 = 305 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL445 ada1a_rat Rat Yes 6.5 IC50 = 305 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
263 3 1 1 4.5 CNCCC=C1C2=CC=CC=C2CCC3=CC=CC=C31
CHEMBL122384 ada1a_rat Rat No 6.5 IC50 = 310 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
345 6 0 2 5.4 CN(C)CCCCC1=CN(C2=C1C=C(C=C2)Cl)C3=CC=C(C=C3)F
CHEMBL654 ada1a_human Human Yes 5.5 IC50 = 3162.3 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
265 0 0 3 3.3 CN1CCN2C(C1)C3=CC=CC=C3CC4=C2N=CC=C4
CHEMBL728 ada1a_rat Rat Yes 7.5 IC50 = 32 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL125291 ada1a_rat Rat No 7.5 IC50 = 32 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
373 5 0 3 5.2 C1CCN(CC1)CCOC2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F
CHEMBL728 ada1a_rat Rat Yes 7.5 IC50 = 32 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
374 4 0 4 4.9 CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL357129 ada1a_human Human No 7.5 IC50 = 32.4 Funct
Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptorBinding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptor
241 4 2 2 1.4 C1CN=C(N1)COC2=CC=CC=C2C3=CC=CN3
CHEMBL3740351 ada1a_human Human No 7.5 IC50 = 32.4 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
470 8 0 5 4.6 CCOC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3740351 ada1a_human Human No 7.5 IC50 = 32.4 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
470 8 0 5 4.6 CCOC1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL566075 ada1a_human Human No 5.5 IC50 = 3200 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
503 6 2 11 5.6 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
CHEMBL566075 ada1a_human Human No 5.5 IC50 = 3200 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
503 6 2 11 5.6 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F
CHEMBL3809543 ada1a_human Human No 6.5 IC50 = 324.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=C(C(=C(C=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL3809543 ada1a_human Human No 6.5 IC50 = 324.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=C(C(=C(C=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL1909065 ada1a_rat Rat No 5.5 IC50 = 3337 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL1909065 ada1a_rat Rat No 5.5 IC50 = 3337 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
917 13 4 17 3.9 CC1CC(C(OC1C2CC(C(O2)C3(CCC(O3)C4(CCC5(O4)CC(C(C(O5)C(C)C6C(C(C(C(O6)(CC(=O)O)O)C)OC)OC)C)O)C)C)OC7CC(C(C(O7)C)OC)OC)(C)O)C
CHEMBL342730 ada1a_rat Rat No 7.5 IC50 = 34 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
421 5 1 3 3.7 CC1=C2C(=CC=C1)N(C=C2C3=CC=C(C=C3)F)C4CCN(CC4)CCN5CCNC5=O
CHEMBL3742103 ada1a_human Human No 7.5 IC50 = 34.5 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
474 6 0 4 5.3 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3742103 ada1a_human Human No 7.5 IC50 = 34.5 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
474 6 0 4 5.3 CC1=C(C=C(C=C1)Cl)N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL143562 ada1a_human Human No 7.5 IC50 = 34.7 Funct
Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptorBinding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptor
256 4 1 3 2.0 CC1=C(OC=C1)C2=CC=CC=C2OCC3=NCCN3
CHEMBL468298 ada1a_human Human No 6.5 IC50 = 340 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
472 6 1 3 6.3 CC1=CC=C(C=C1)N(C2=CC=C(C=C2)F)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL19476 ada1a_rat Rat Yes 6.5 IC50 = 340 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat prostate Alpha-1A adrenergic receptor subtype.Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the rat prostate Alpha-1A adrenergic receptor subtype.
523 8 2 9 3.1 CC(C)(C)NC(=O)C1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL468298 ada1a_human Human No 6.5 IC50 = 340 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
472 6 1 3 6.3 CC1=CC=C(C=C1)N(C2=CC=C(C=C2)F)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL3741079 ada1a_human Human No 5.5 IC50 = 3421 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 6 0 4 5.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Br
CHEMBL3741079 ada1a_human Human No 5.5 IC50 = 3421 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 6 0 4 5.0 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Br
CHEMBL162501 ada1a_human Human Yes 6.5 IC50 = 346.7 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
359 3 0 4 2.8 CC1=C(C(=O)N2C=CC=CC2=N1)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL49 ada1a_rat Rat Yes 5.5 IC50 = 3482 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL49 ada1a_rat Rat Yes 5.5 IC50 = 3482 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
386 6 0 6 2.6 C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
CHEMBL3805559 ada1a_human Human No 7.5 IC50 = 35 Funct
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
426 8 1 6 4.1 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL3805559 ada1a_human Human No 7.5 IC50 = 35 Funct
Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay
426 8 1 6 4.1 CNC(=O)C1=CC(=CC=C1)OCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL155327 ada1a_human Human No 7.5 IC50 = 35.5 Funct
In vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cellsIn vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cells
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CC=NO3
CHEMBL523882 ada1a_human Human No 6.5 IC50 = 350 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
490 6 1 4 6.4 CC1=CC=C(C=C1)N(C2=CC(=C(C=C2)F)F)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL523882 ada1a_human Human No 6.5 IC50 = 350 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
490 6 1 4 6.4 CC1=CC=C(C=C1)N(C2=CC(=C(C=C2)F)F)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL1113 ada1a_rat Rat Yes 6.5 IC50 = 357 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL1113 ada1a_rat Rat Yes 6.5 IC50 = 357 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
314 1 1 3 2.6 C1CN(CCN1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
CHEMBL295698 ada1a_rat Rat Yes 4.5 IC50 = 35729 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
531 7 0 6 4.3 CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl
CHEMBL3739762 ada1a_human Human No 7.4 IC50 = 36.1 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 [C-]#[N+]C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3739762 ada1a_human Human No 7.4 IC50 = 36.1 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
451 6 0 5 4.0 [C-]#[N+]C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL99653 ada1a_rat Rat No 6.4 IC50 = 360 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
315 4 1 5 3.8 CN(C)CC(C1=CC(=CC=C1)C(F)(F)F)C2(CCCCC2)O
CHEMBL577904 ada1a_human Human No 5.4 IC50 = 3600 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
403 6 2 7 4.0 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=C(C=C3)F)F
CHEMBL493962 ada1a_human Human No 5.4 IC50 = 3600 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
480 7 0 5 4.7 CN(CCCC1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=CC=N5
CHEMBL577904 ada1a_human Human No 5.4 IC50 = 3600 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptorDisplacement of [3H]prazosin from human adrenergic alpha1A receptor
403 6 2 7 4.0 CC1=CN=C(N=C1N(C)C)NC2CCC(CC2)CNC(=O)C3=CC(=C(C=C3)F)F
CHEMBL493962 ada1a_human Human No 5.4 IC50 = 3600 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
480 7 0 5 4.7 CN(CCCC1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC(=C(C=C4)F)F)N5C=CC=N5
CHEMBL98894 ada1a_rat Rat No 7.4 IC50 = 37 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
316 4 1 2 4.2 CN(C)CC(C1=CC(=C(C=C1)Cl)Cl)C2(CCCCC2)O
CHEMBL42 ada1a_rat Rat Yes 7.4 IC50 = 38 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
327 1 1 4 3.2 CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
CHEMBL3810187 ada1a_human Human No 7.4 IC50 = 38.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
524 14 3 9 4.4 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3810187 ada1a_human Human No 7.4 IC50 = 38.2 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
524 14 3 9 4.4 CCC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO
CHEMBL3739542 ada1a_human Human No 6.4 IC50 = 384.2 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5C(F)(F)F
CHEMBL3739542 ada1a_human Human No 6.4 IC50 = 384.2 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
494 6 0 7 5.2 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=C5C(F)(F)F
CHEMBL216443 ada1a_rat Rat No 5.4 IC50 = 3890.5 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC(=CC=C4)CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=CC(=C5)C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL331077 ada1a_human Human No 6.4 IC50 = 398.1 Funct
Binding affinity against Alpha-1A adrenergic receptorBinding affinity against Alpha-1A adrenergic receptor
295 2 0 4 2.8 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=NC=C4
CHEMBL163190 ada1a_human Human No 6.4 IC50 = 398.1 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
373 3 0 4 3.1 CC1=CC=CC2=NC(=C(C(=O)N12)CCN3CCC4=C(C3)C5=CC=CC=C5O4)C
CHEMBL3809630 ada1a_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
514 13 3 10 3.7 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL3809630 ada1a_human Human No 8.4 IC50 = 4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
514 13 3 10 3.7 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OCC(F)(F)F
CHEMBL3809319 ada1a_human Human No 8.4 IC50 = 4.4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 2.4 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OC
CHEMBL3809319 ada1a_human Human No 8.4 IC50 = 4.4 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
426 12 3 5 2.4 CC(CC1=CC(=C2C(=C1)C=CN2CCCO)C(=O)N)NCCOC3=CC=CC=C3OC
CHEMBL3809600 ada1a_human Human No 8.3 IC50 = 4.6 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3809600 ada1a_human Human No 8.3 IC50 = 4.6 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
446 12 3 7 2.6 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=C(C=C(C=C3)F)OC
CHEMBL3808408 ada1a_human Human No 8.3 IC50 = 4.8 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
428 12 3 6 2.5 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OC
CHEMBL3808408 ada1a_human Human No 8.3 IC50 = 4.8 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
428 12 3 6 2.5 CC(CC1=CC2=C(C(=C1)C(=O)N)N(CC2)CCCO)NCCOC3=CC=CC=C3OC
CHEMBL332365 ada1a_rat Rat No 7.4 IC50 = 40 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
317 4 0 2 4.7 CN(C)CCC1=CN(C2=C1C=C(C=C2)Cl)C3=CC=C(C=C3)F
CHEMBL418499 ada1a_bovin Bovine No 6.4 IC50 = 400 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
421 4 0 7 4.6 CN1C2=C(C=C(C=C2)CCN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F)SC1=O
CHEMBL331193 ada1a_rat Rat No 6.4 IC50 = 400 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
457 8 0 3 4.8 CC(C)N1CCN(C1=O)CCN(C)CCC2=CN(C3=C2C=CC(=C3)Cl)C4=CC=C(C=C4)F
CHEMBL423841 ada1a_bovin Bovine No 5.4 IC50 = 4000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
408 8 0 5 3.9 CCCN(CCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL54089 ada1a_bovin Bovine No 5.4 IC50 = 4000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
408 8 0 5 3.9 CCCN(CCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL285010 ada1a_bovin Bovine No 4.4 IC50 = 40000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
233 2 0 3 2.5 COC1=CC=CC2=C1CC(CO2)N3CCCC3
CHEMBL333774 ada1a_rat Rat No 7.4 IC50 = 41 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
431 8 1 4 3.5 CN(CCN1CCNC1=O)CCOC2=CN(C3=C2C=CC(=C3)Cl)C4=CC=C(C=C4)F
CHEMBL85735 ada1a_human Human No 7.4 IC50 = 42.7 Funct
Binding affinity for human cloned Alpha-1A adrenergic receptorBinding affinity for human cloned Alpha-1A adrenergic receptor
308 2 0 3 4.2 CC1=CC2=C(CC3=CC=CC=C3C4N2OC(C4)CN(C)C)C=C1
CHEMBL453653 ada1a_human Human No 5.4 IC50 = 4200 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
420 5 0 5 4.0 CN1C(=NC2=C(C1=O)C(=CC=C2)OC)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL453653 ada1a_human Human No 5.4 IC50 = 4200 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
420 5 0 5 4.0 CN1C(=NC2=C(C1=O)C(=CC=C2)OC)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL122042 ada1a_rat Rat No 7.4 IC50 = 43 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
429 8 1 3 4.1 CN(CCCC1=CN(C2=C1C=C(C=C2)Cl)C3=CC=C(C=C3)F)CCN4CCNC4=O
CHEMBL329923 ada1a_rat Rat No 6.4 IC50 = 435 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
298 4 1 2 2.7 CN(C)CC(C1=CC=C(C=C1)Br)C2(CCC2)O
CHEMBL84931 ada1a_human Human No 7.4 IC50 = 44.7 Funct
Binding affinity for human cloned Alpha-1A adrenergic receptorBinding affinity for human cloned Alpha-1A adrenergic receptor
312 2 0 4 4.0 CN(C)CC1CC2C3=CC=CC=C3CC4=C(N2O1)C=C(C=C4)F
CHEMBL64845 ada1a_bovin Bovine No 7.4 IC50 = 45 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
436 6 1 7 5.2 C1CN(CCN1CCCCC2=CC3=C(C=C2)NC(=O)S3)C4=CC=CC(=C4)C(F)(F)F
CHEMBL155326 ada1a_human Human No 7.3 IC50 = 45.7 Funct
In vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cellsIn vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cells
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=NC=CO3
CHEMBL454642 ada1a_human Human No 5.4 IC50 = 4500 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
407 4 0 5 4.1 CN1C(=NC2=C(C1=O)C=CC=C2F)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL454642 ada1a_human Human No 5.4 IC50 = 4500 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
407 4 0 5 4.1 CN1C(=NC2=C(C1=O)C=CC=C2F)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL3809314 ada1a_human Human No 6.3 IC50 = 453.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL3809314 ada1a_human Human No 6.3 IC50 = 453.9 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
508 13 3 8 3.9 CC1=CC(=C(C=C1)OCC(F)(F)F)OCCNC(C)CC2=CC(=C3C(=C2)C=CN3CCCO)C(=O)N
CHEMBL117381 ada1a_human Human No 6.3 IC50 = 457.1 Funct
In vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cellsIn vitro binding affinity against human Alpha-1A adrenergic receptor expressed in rat-1 fibroblasts cells
242 4 2 4 1.0 C1CN=C(N1)CNC2=CC=CC=C2C3=CN=CO3
CHEMBL3742276 ada1a_human Human No 7.3 IC50 = 46.4 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 7 0 6 3.5 CS(=O)(=O)C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL3742276 ada1a_human Human No 7.3 IC50 = 46.4 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
504 7 0 6 3.5 CS(=O)(=O)C1=CC=CC=C1N2CCN(CC2)CCC3=CC=C(C=C3)CN4C(=O)C5=CC=CC=C5C4=O
CHEMBL320419 ada1a_human Human No 6.3 IC50 = 467.7 Funct
Concentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in humanConcentration required for 50% inhibition of binding against Alpha-1A adrenergic receptor in human
274 7 3 3 2.0 CCCCNC(=O)C1=CC=CC=C1NCC2=NCCN2
CHEMBL494009 ada1a_human Human No 6.3 IC50 = 470 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
506 6 0 5 5.1 CC1=CC=C(C=C1)N(C2=CC(=C(C=C2)F)F)C(=O)N(C)CCCN3CCC4(CC3)C5=CC=CC=C5CO4
CHEMBL494009 ada1a_human Human No 6.3 IC50 = 470 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
506 6 0 5 5.1 CC1=CC=C(C=C1)N(C2=CC(=C(C=C2)F)F)C(=O)N(C)CCCN3CCC4(CC3)C5=CC=CC=C5CO4
CHEMBL162682 ada1a_human Human No 6.3 IC50 = 478.6 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
485 3 0 4 3.0 CC1=C(C(=O)N2C=C(C=CC2=N1)I)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL3739533 ada1a_human Human No 7.3 IC50 = 49.6 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
427 6 0 5 3.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=N5
CHEMBL3739533 ada1a_human Human No 7.3 IC50 = 49.6 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
427 6 0 5 3.5 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=CC=N5
CHEMBL468509 ada1a_human Human No 6.3 IC50 = 490 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
472 6 1 3 6.3 CC1=CC=C(C=C1)N(C2=CC(=CC=C2)F)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL468509 ada1a_human Human No 6.3 IC50 = 490 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
472 6 1 3 6.3 CC1=CC=C(C=C1)N(C2=CC(=CC=C2)F)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL479 ada1a_rat Rat Yes 8.3 IC50 = 5.1 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
371 4 0 4 5.9 CN1CCCCC1CCN2C3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL1909072 ada1a_rat Rat Yes 8.3 IC50 = 5.1 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL1909072 ada1a_rat Rat Yes 8.3 IC50 = 5.1 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
402 5 1 4 4.4 C1CN(CCC1C(=O)N)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
CHEMBL421244 ada1a_rat Rat No 8.2 IC50 = 5.7 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
431 8 1 4 3.5 CN(CCN1CCNC1=O)CCOC2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F
CHEMBL356605 ada1a_human Human No 7.3 IC50 = 50.1 Funct
Binding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptorBinding affinity of compound towards Alpha-1A adrenergic receptor using membranes prepared from Rat-1 fibroblasts expressing human Alpha-1A adrenergic receptor
253 4 1 3 1.5 C1CN=C(N1)COC2=CC=CC=C2C3=CN=CC=C3
CHEMBL3403995 ada1a_human Human No 6.3 IC50 = 500 Funct
Inhibition of alpha-adrenoceptor 1A (unknown origin)Inhibition of alpha-adrenoceptor 1A (unknown origin)
514 14 2 7 3.2 CC(C)N(CC1CNCC1OC(=O)NCC2=CC=CC=C2)C(=O)C3=CC(=C(C=C3)OC)OCCCOC
CHEMBL141721 ada1a_rat Rat No 6.3 IC50 = 500 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
323 2 0 3 4.5 CC1=CC2=C(C=C1)N(C=C2C3=CC=C(C=C3)F)N4CCN(CC4)C
CHEMBL346389 ada1a_rat Rat Yes 6.3 IC50 = 500 Funct
Inhibition of [3H]- prazosin binding against Alpha-1A adrenergic receptor from rat submaxillary glandInhibition of [3H]- prazosin binding against Alpha-1A adrenergic receptor from rat submaxillary gland
358 3 1 4 2.9 C1CN(CCN1CC2=CC3=C(C=C2)NC(=O)CO3)C4=CC=C(C=C4)Cl
CHEMBL3403995 ada1a_human Human No 6.3 IC50 = 500 Funct
Inhibition of alpha-adrenoceptor 1A (unknown origin)Inhibition of alpha-adrenoceptor 1A (unknown origin)
514 14 2 7 3.2 CC(C)N(CC1CNCC1OC(=O)NCC2=CC=CC=C2)C(=O)C3=CC(=C(C=C3)OC)OCCCOC
CHEMBL283207 ada1a_bovin Bovine No 5.3 IC50 = 5000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
423 9 0 5 4.3 CCCN(CCCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL52396 ada1a_bovin Bovine No 5.3 IC50 = 5000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
423 9 0 5 4.3 CCCN(CCCCN1C(=O)C2=CC=CC=C2C1=O)C3CC4=C(C=CC=C4OC)OC3
CHEMBL416747 ada1a_bovin Bovine No 5.3 IC50 = 5000 Funct
Binding affinity against alpha-1 adrenergic receptor in calf frontal cortexBinding affinity against alpha-1 adrenergic receptor in calf frontal cortex
361 9 0 4 4.5 CCCN(CCCCN1CCCCC1)C2CC3=C(C=CC=C3OC)OC2
CHEMBL263289 ada1a_rat Rat No 5.3 IC50 = 5011.9 Funct
Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat
1162 33 6 20 6.2 COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CC=C4CNCCCCCCNCCSSCCNCCCCCCNCC5=CC=CC=C5C(=O)N6CCN(CC6)C7=NC8=CC(=C(C=C8C(=N7)N)OC)OC)N)OC
CHEMBL319142 ada1a_rat Rat No 7.3 IC50 = 52 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
326 4 1 2 3.6 CN(C)CC(C1=CC(=CC=C1)Br)C2(CCCCC2)O
CHEMBL3582272 ada1a_human Human No 7.3 IC50 = 52.4 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
586 9 1 12 3.4 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)CN4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL3582272 ada1a_human Human No 7.3 IC50 = 52.4 Funct
Displacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysisDisplacement of [3H]-Prazosin from human alpha-1A adrenergic receptor transfected in CHO cell membranes after 2 hrs by microplate scintillation counting analysis
586 9 1 12 3.4 CCN(CC)C1=CC2=C(C=C1)C=C(C(=O)O2)N3C=C(N=N3)CN4CCN(CC4)C5=NC6=CC(=C(C=C6C(=N5)N)OC)OC
CHEMBL316862 ada1a_rat Rat Yes 6.3 IC50 = 523 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
282 4 1 2 3.6 CN(C)CC(C1=CC=CC=C1Cl)C2(CCCCC2)O
CHEMBL162058 ada1a_human Human No 5.3 IC50 = 5248.1 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
419 5 0 6 2.2 CC1=C(C(=O)N2C=C(C(=CC2=N1)OC)OC)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL1626 ada1a_rat Rat Yes 7.3 IC50 = 53 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL1626 ada1a_rat Rat Yes 7.3 IC50 = 53 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
344 6 0 2 5.0 CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCC3CCCN3C
CHEMBL83658 ada1a_human Human No 6.3 IC50 = 537.0 Funct
Binding affinity against Alpha-1A adrenergic receptorBinding affinity against Alpha-1A adrenergic receptor
294 2 0 3 3.9 CN(C)CC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL83658 ada1a_human Human No 6.3 IC50 = 537.0 Funct
Binding affinity for human cloned Alpha-1A adrenergic receptorBinding affinity for human cloned Alpha-1A adrenergic receptor
294 2 0 3 3.9 CN(C)CC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL332425 ada1a_rat Rat No 7.3 IC50 = 54 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
429 8 1 3 4.1 CN(CCCN1CCNC1=O)CCC2=CN(C3=C2C=CC(=C3)Cl)C4=CC=C(C=C4)F
CHEMBL356799 ada1a_rat Rat No 7.3 IC50 = 54 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
423 5 1 3 3.9 CC1=CC2=C(C=C1)N(C=C2C3=CC=C(C=C3)F)C4CCN(CC4)CCN(C)C(=O)NC
CHEMBL468299 ada1a_human Human No 6.3 IC50 = 540 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
468 6 1 2 6.6 CC1=CC=C(C=C1)N(C2=CC=C(C=C2)C)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL20734 ada1a_rat Rat Yes 6.3 IC50 = 540 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
388 6 2 4 3.9 CC1C(CCN1CC2=CC=CC=C2)NC(=O)C3=CC(=C(C=C3OC)NC)Cl
CHEMBL468299 ada1a_human Human No 6.3 IC50 = 540 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
468 6 1 2 6.6 CC1=CC=C(C=C1)N(C2=CC=C(C=C2)C)C(=O)NCCCN3CCC4(CCC5=CC=CC=C54)CC3
CHEMBL490533 ada1a_human Human Yes 5.3 IC50 = 5400 Funct
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay
339 2 0 5 3.1 COC1=C(C2=C(CC3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC
CHEMBL3741483 ada1a_human Human No 6.3 IC50 = 551.9 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL3741483 ada1a_human Human No 6.3 IC50 = 551.9 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
460 6 0 4 4.9 C1CN(CCN1CCC2=CC=C(C=C2)CN3C(=O)C4=CC=CC=C4C3=O)C5=CC=C(C=C5)Cl
CHEMBL142635 ada1a_human Human Yes 6.3 IC50 = 555 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1a_human Human Yes 6.3 IC50 = 555 Funct
Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL142635 ada1a_human Human Yes 6.3 IC50 = 555 Funct
Antagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) by firefly and renilla dual glo luciferase assay
392 7 1 5 4.1 COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
CHEMBL584606 ada1a_rat Rat No 7.3 IC50 = 56 Funct
Displacement of [3H]prazosin from adrenergic alpha1A receptor in Wistar rat submaxillary gland after 60 minsDisplacement of [3H]prazosin from adrenergic alpha1A receptor in Wistar rat submaxillary gland after 60 mins
367 6 1 5 2.4 CC1=CC=C(C=C1)N2CCN(CC2)CCCN3C(=O)C(=C(C(=N3)C)C=C)N
CHEMBL584606 ada1a_rat Rat No 7.3 IC50 = 56 Funct
Displacement of [3H]prazosin from adrenergic alpha1A receptor in Wistar rat submaxillary gland after 60 minsDisplacement of [3H]prazosin from adrenergic alpha1A receptor in Wistar rat submaxillary gland after 60 mins
367 6 1 5 2.4 CC1=CC=C(C=C1)N2CCN(CC2)CCCN3C(=O)C(=C(C(=N3)C)C=C)N
CHEMBL21731 ada1a_rat Rat Yes 6.3 IC50 = 567 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL21731 ada1a_rat Rat Yes 6.3 IC50 = 567 Funct
DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)
277 4 1 1 4.6 CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24
CHEMBL3809032 ada1a_human Human No 7.2 IC50 = 57 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
456 13 3 6 3.3 CCC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL3809032 ada1a_human Human No 7.2 IC50 = 57 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
456 13 3 6 3.3 CCC1=CC(=C(C=C1)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)OC
CHEMBL3809500 ada1a_human Human No 7.2 IC50 = 58 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=CC(=C(C(=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL3809500 ada1a_human Human No 7.2 IC50 = 58 Funct
Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins
440 11 3 5 3.7 CC1=CC(=C(C(=C1)C)OCCNC(C)CC2=CC3=C(C(=C2)C(=O)N)N(CC3)CCCO)C
CHEMBL162147 ada1a_human Human No 5.2 IC50 = 5888.4 Funct
Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.Binding affinity at human Alpha-1A adrenergic receptor in CHO cells uby [3H]prazosin (0.25 nM) displacement.
462 3 0 7 4.0 CC1=C(C(=O)N2C=C(C=C(C2=N1)Cl)C(F)(F)F)CCN3CCC4=C(C3)C5=CC=CC=C5O4
CHEMBL19476 ada1a_human Human Yes 6.2 IC50 = 590 Funct
Compound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtypeCompound was tested for the tissue binding affinity using [3H]- Prazosin as radioligand to the human prostate Alpha-1A adrenergic receptor subtype
523 8 2 9 3.1 CC(C)(C)NC(=O)C1CN(CCN1C(=O)OCC2=CC=CC=C2)C3=NC4=CC(=C(C=C4C(=N3)N)OC)OC
CHEMBL453654 ada1a_human Human No 5.2 IC50 = 5900 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
420 5 0 5 4.0 CN1C(=NC2=C(C1=O)C=C(C=C2)OC)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL453654 ada1a_human Human No 5.2 IC50 = 5900 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in LMtk- cells
420 5 0 5 4.0 CN1C(=NC2=C(C1=O)C=C(C=C2)OC)C3=CC=C(C=C3)OC4CCN(CC4)C5CCC5
CHEMBL294730 ada1a_bovin Bovine No 8.2 IC50 = 6 Funct
Affinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosinAffinity towards Alpha-1A adrenergic receptor in membranes from bovine frontal cortex using [3H]prazosin
398 6 0 5 4.1 CN1C2=C(C=C(C=C2)CCCN3CCN(CC3)C4=CC=CC=C4OC)SC1=O
CHEMBL359031 ada1a_rat Rat Yes 8.2 IC50 = 6.3 Funct
Displacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranesDisplacement of [3H]prazosin from Alpha-1 adrenergic receptor in whole rat brain membranes
407 5 1 3 3.3 C1CN(CCC1N2C=C(C3=CC=CC=C32)C4=CC=C(C=C4)F)CCN5CCNC5=O
CHEMBL1118 ada1a_rat Rat Yes 7.2 IC50 = 60 Funct
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainInhibition of binding of [3H]imipramine to imipramine receptor in rat brain
263 4 2 3 2.6 CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O
CHEMBL494016 ada1a_human Human No 6.2 IC50 = 600 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
491 7 0 5 4.9 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC=CC=C4)C5=CC(=C(C=C5)F)F
CHEMBL122047 ada1a_rat Rat No 6.2 IC50 = 600 Funct
Binding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranesBinding affinity to the alpha-1 adrenergic receptor using a radioligand [3H]prazosin binding assay in rat brain membranes
473 9 0 4 4.5 CC(C)N1CCN(C1=O)CCN(C)CCOC2=CN(C3=C2C=CC(=C3)Cl)C4=CC=C(C=C4)F
CHEMBL494016 ada1a_human Human No 6.2 IC50 = 600 Funct
Displacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cellsDisplacement of [3H]prazosin from human adrenergic alpha1A receptor expressed in thymidine kinase-deficient mouse LM cells
491 7 0 5 4.9 CN(CCCN1CCC2(CC1)C3=CC=CC=C3CO2)C(=O)C(C4=CC=CC=C4)C5=CC(=C(C=C5)F)F
CHEMBL26975 ada1a_bovin Bovine No 5.2 IC50 = 6000 Funct