GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3658	4107	None	38	Human	Functional	pAC50	=	9.5	9.5	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	None	38	Human	Functional	pAC50	=	9.5	9.5	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	None	38	Human	Functional	pAC50	=	9.5	9.5	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709.0	4107	None	38	Human	Functional	pAC50	=	9.5	9.5	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	None	38	Human	Functional	pAC50	=	9.5	9.5	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	None	38	Human	Functional	pAC50	=	9.5	9.5	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	11079	2733	None	38	Human	Functional	pAC50	=	9.2	9.2	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	2733	None	38	Human	Functional	pAC50	=	9.2	9.2	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	2733	None	38	Human	Functional	pAC50	=	9.2	9.2	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436.0	2733	None	38	Human	Functional	pAC50	=	9.2	9.2	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	2733	None	38	Human	Functional	pAC50	=	9.2	9.2	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	2733	None	38	Human	Functional	pAC50	=	9.2	9.2	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	2733	None	38	Human	Functional	pAC50	=	9.2	9.2	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	2142	3096	None	36	Human	Functional	pAC50	=	9.1	9.1	-1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3096	None	36	Human	Functional	pAC50	=	9.1	9.1	-1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3096	None	36	Human	Functional	pAC50	=	9.1	9.1	-1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3096	None	36	Human	Functional	pAC50	=	9.1	9.1	-1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775.0	3096	None	36	Human	Functional	pAC50	=	9.1	9.1	-1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3096	None	36	Human	Functional	pAC50	=	9.1	9.1	-1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3096	None	36	Human	Functional	pAC50	=	9.1	9.1	-1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	1960	2857	None	46	Human	Functional	pAC50	=	8.9	8.9	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2857	None	46	Human	Functional	pAC50	=	8.9	8.9	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260.0	2857	None	46	Human	Functional	pAC50	=	8.9	8.9	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2857	None	46	Human	Functional	pAC50	=	8.9	8.9	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2857	None	46	Human	Functional	pAC50	=	8.9	8.9	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2857	None	46	Human	Functional	pAC50	=	8.9	8.9	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	11079	2733	None	38	Human	Functional	pAC50	=	8.9	8.9	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3369	2733	None	38	Human	Functional	pAC50	=	8.9	8.9	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436	2733	None	38	Human	Functional	pAC50	=	8.9	8.9	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	4436.0	2733	None	38	Human	Functional	pAC50	=	8.9	8.9	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	5509	2733	None	38	Human	Functional	pAC50	=	8.9	8.9	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL761	2733	None	38	Human	Functional	pAC50	=	8.9	8.9	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB06711	2733	None	38	Human	Functional	pAC50	=	8.9	8.9	5	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	3036780	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3036780.0	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	46780481	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970.0	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL504548	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	DB06216	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-7	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	2803	955	None	40	Human	Functional	pAC50	=	8.8	8.8	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	2803.0	955	None	40	Human	Functional	pAC50	=	8.8	8.8	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	516	955	None	40	Human	Functional	pAC50	=	8.8	8.8	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	704	955	None	40	Human	Functional	pAC50	=	8.8	8.8	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	CHEMBL134	955	None	40	Human	Functional	pAC50	=	8.8	8.8	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	DB00575	955	None	40	Human	Functional	pAC50	=	8.8	8.8	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	1960	2857	None	46	Human	Functional	pAC50	=	8.8	8.8	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2857	None	46	Human	Functional	pAC50	=	8.8	8.8	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260.0	2857	None	46	Human	Functional	pAC50	=	8.8	8.8	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2857	None	46	Human	Functional	pAC50	=	8.8	8.8	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2857	None	46	Human	Functional	pAC50	=	8.8	8.8	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2857	None	46	Human	Functional	pAC50	=	8.8	8.8	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	129211	3749	None	48	Human	Functional	pAC50	=	8.8	8.8	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	129211.0	3749	None	48	Human	Functional	pAC50	=	8.8	8.8	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3749	None	48	Human	Functional	pAC50	=	8.8	8.8	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3749	None	48	Human	Functional	pAC50	=	8.8	8.8	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3749	None	48	Human	Functional	pAC50	=	8.8	8.8	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3749	None	48	Human	Functional	pAC50	=	8.8	8.8	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	124	2981	None	32	Human	Functional	pAC50	=	8.7	8.7	-8	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	None	32	Human	Functional	pAC50	=	8.7	8.7	-8	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	None	32	Human	Functional	pAC50	=	8.7	8.7	-8	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636.0	2981	None	32	Human	Functional	pAC50	=	8.7	8.7	-8	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	None	32	Human	Functional	pAC50	=	8.7	8.7	-8	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	None	32	Human	Functional	pAC50	=	8.7	8.7	-8	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	16351	102785	None	36	Human	Functional	pAC50	=	8	8.0	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	16351.0	102785	None	36	Human	Functional	pAC50	=	8	8.0	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102785	None	36	Human	Functional	pAC50	=	8	8.0	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB13256	102785	None	36	Human	Functional	pAC50	=	8	8.0	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	9429	204590	None	44	Human	Functional	pAC50	=	6	6.0	-5	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	9429.0	204590	None	44	Human	Functional	pAC50	=	6	6.0	-5	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL609109	204590	None	44	Human	Functional	pAC50	=	6	6.0	-5	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	DB01622	204590	None	44	Human	Functional	pAC50	=	6	6.0	-5	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
	3599	16886	None	60	Human	Functional	pAC50	=	5	5.0	1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	20	0	4	5.7	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL125	16886	None	60	Human	Functional	pAC50	=	5	5.0	1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	20	0	4	5.7	CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	3062316	33583	None	70	Human	Functional	pAC50	=	5	5.0	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33583	None	70	Human	Functional	pAC50	=	5	5.0	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL5416410	33583	None	70	Human	Functional	pAC50	=	5	5.0	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	54676537	152943	None	53	Human	Functional	pAC50	=	5	5.0	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	353	5	1	6	3.5	CC(=O)CC(c1ccc([N+](=O)[O-])cc1)c1c(O)c2ccccc2oc1=O	10.1038/s41467-023-40064-9
	CHEMBL397420	152943	None	53	Human	Functional	pAC50	=	5	5.0	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	353	5	1	6	3.5	CC(=O)CC(c1ccc([N+](=O)[O-])cc1)c1c(O)c2ccccc2oc1=O	10.1038/s41467-023-40064-9
	2162	41527	None	58	Human	Functional	pAC50	=	5.0	5.0	-5	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41527	None	58	Human	Functional	pAC50	=	5.0	5.0	-5	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	3783	14010	None	16	Human	Functional	pAC50	=	6.0	6.0	-27	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1197051	14010	None	16	Human	Functional	pAC50	=	6.0	6.0	-27	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	6989215	1485	None	54	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	7391	1485	None	54	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	92974	1485	None	54	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	92974.0	1485	None	54	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	971	1485	None	54	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	CHEMBL2103827	1485	None	54	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	DB06262	1485	None	54	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	213	3	5	5	-0.5	OC(=O)[C@H]([C@@H](c1ccc(c(c1)O)O)O)N	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	6.0	6.0	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2683	102943	None	17	Human	Functional	pAC50	=	5.0	5.0	-812	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL305906	102943	None	17	Human	Functional	pAC50	=	5.0	5.0	-812	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL334255	102943	None	17	Human	Functional	pAC50	=	5.0	5.0	-812	24	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	6.0	6.0	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	6.0	6.0	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	6.0	6.0	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	6.0	6.0	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	6.0	6.0	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	6.0	6.0	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	9417	133581	None	40	Human	Functional	pAC50	=	6.0	6.0	-33	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133581	None	40	Human	Functional	pAC50	=	6.0	6.0	-33	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133581	None	40	Human	Functional	pAC50	=	6.0	6.0	-33	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	22530	56146	None	40	Human	Functional	pAC50	=	6.0	6.0	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1600878	56146	None	40	Human	Functional	pAC50	=	6.0	6.0	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL1625607	56146	None	40	Human	Functional	pAC50	=	6.0	6.0	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
	60860	208097	None	26	Human	Functional	pAC50	=	5.0	5.0	-21	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	CHEMBL1615777	208097	None	26	Human	Functional	pAC50	=	5.0	5.0	-21	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	CHEMBL818	208097	None	26	Human	Functional	pAC50	=	5.0	5.0	-21	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
	5354	155746	None	16	Human	Functional	pAC50	=	5.0	5.0	-102	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL404849	155746	None	16	Human	Functional	pAC50	=	5.0	5.0	-102	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
	2441	98678	None	12	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	1	1	3	2.6	O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1	10.1038/s41467-023-40064-9
	CHEMBL277062	98678	None	12	Human	Functional	pAC50	=	5.0	5.0	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	1	1	3	2.6	O=C1CN=C(c2ccccn2)c2cc(Br)ccc2N1	10.1038/s41467-023-40064-9
	104850	3330	None	58	Human	Functional	pAC50	=	5.0	5.0	-1122	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3330	None	58	Human	Functional	pAC50	=	5.0	5.0	-1122	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3330	None	58	Human	Functional	pAC50	=	5.0	5.0	-1122	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3330	None	58	Human	Functional	pAC50	=	5.0	5.0	-1122	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3330	None	58	Human	Functional	pAC50	=	5.0	5.0	-1122	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	1056	3371	None	67	Human	Functional	pAC50	=	5.0	5.0	-19	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	None	67	Human	Functional	pAC50	=	5.0	5.0	-19	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	None	67	Human	Functional	pAC50	=	5.0	5.0	-19	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	None	67	Human	Functional	pAC50	=	5.0	5.0	-19	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	None	67	Human	Functional	pAC50	=	5.0	5.0	-19	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	4499	59795	None	61	Human	Functional	pAC50	=	5.0	5.0	-6	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL1726	59795	None	61	Human	Functional	pAC50	=	5.0	5.0	-6	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	103	4153	None	44	Human	Functional	pAC50	=	8.0	8.0	1	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	None	44	Human	Functional	pAC50	=	8.0	8.0	1	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	None	44	Human	Functional	pAC50	=	8.0	8.0	1	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	None	44	Human	Functional	pAC50	=	8.0	8.0	1	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	None	44	Human	Functional	pAC50	=	8.0	8.0	1	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	10184665	3991	None	42	Human	Functional	pAC50	=	6.0	6.0	-645	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	10184665.0	3991	None	42	Human	Functional	pAC50	=	6.0	6.0	-645	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	3991	None	42	Human	Functional	pAC50	=	6.0	6.0	-645	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	3991	None	42	Human	Functional	pAC50	=	6.0	6.0	-645	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	3991	None	42	Human	Functional	pAC50	=	6.0	6.0	-645	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	3991	None	42	Human	Functional	pAC50	=	6.0	6.0	-645	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	2267	559	None	45	Human	Functional	pAC50	=	6.0	6.0	-45	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2267.0	559	None	45	Human	Functional	pAC50	=	6.0	6.0	-45	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	None	45	Human	Functional	pAC50	=	6.0	6.0	-45	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	None	45	Human	Functional	pAC50	=	6.0	6.0	-45	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	None	45	Human	Functional	pAC50	=	6.0	6.0	-45	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	None	45	Human	Functional	pAC50	=	6.0	6.0	-45	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2274	3173	None	38	Human	Functional	pAC50	=	6.0	6.0	-24	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	None	38	Human	Functional	pAC50	=	6.0	6.0	-24	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917.0	3173	None	38	Human	Functional	pAC50	=	6.0	6.0	-24	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	None	38	Human	Functional	pAC50	=	6.0	6.0	-24	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	None	38	Human	Functional	pAC50	=	6.0	6.0	-24	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	None	38	Human	Functional	pAC50	=	6.0	6.0	-24	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2601	3780	None	25	Human	Functional	pAC50	=	6.0	6.0	-354	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	None	25	Human	Functional	pAC50	=	6.0	6.0	-354	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	None	25	Human	Functional	pAC50	=	6.0	6.0	-354	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	None	25	Human	Functional	pAC50	=	6.0	6.0	-354	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	None	25	Human	Functional	pAC50	=	6.0	6.0	-354	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	11626560	203394	None	56	Human	Functional	pAC50	=	6.0	6.0	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	203394	None	56	Human	Functional	pAC50	=	6.0	6.0	-1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	10071196	3124	None	53	Human	Functional	pAC50	=	4.9	4.9	-776	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	10071196.0	3124	None	53	Human	Functional	pAC50	=	4.9	4.9	-776	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	5142	3124	None	53	Human	Functional	pAC50	=	4.9	4.9	-776	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	8423	3124	None	53	Human	Functional	pAC50	=	4.9	4.9	-776	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	CHEMBL2111101	3124	None	53	Human	Functional	pAC50	=	4.9	4.9	-776	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	DB05316	3124	None	53	Human	Functional	pAC50	=	4.9	4.9	-776	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
	3675	7736	None	46	Human	Functional	pAC50	=	4.9	4.9	-91	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1089	7736	None	46	Human	Functional	pAC50	=	4.9	4.9	-91	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	136	3	2	2	0.7	NNCCc1ccccc1	10.1038/s41467-023-40064-9
	135409453	3773	None	26	Human	Functional	pAC50	=	5.9	5.9	-363	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	None	26	Human	Functional	pAC50	=	5.9	5.9	-363	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	None	26	Human	Functional	pAC50	=	5.9	5.9	-363	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	4.9	4.9	-13803	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	4.9	4.9	-13803	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	4.9	4.9	-13803	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	4.9	4.9	-13803	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	4.9	4.9	-13803	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Functional	pAC50	=	6.9	6.9	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Functional	pAC50	=	6.9	6.9	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Functional	pAC50	=	6.9	6.9	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Functional	pAC50	=	6.9	6.9	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Functional	pAC50	=	6.9	6.9	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Functional	pAC50	=	6.9	6.9	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	4822	45046	None	35	Human	Functional	pAC50	=	6.9	6.9	-16	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL152408	45046	None	35	Human	Functional	pAC50	=	6.9	6.9	-16	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
	16351	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	16351.0	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB13256	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-17	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	37264	189531	None	18	Human	Functional	pAC50	=	5.9	5.9	8	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL513301	189531	None	18	Human	Functional	pAC50	=	5.9	5.9	8	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	435	6	2	10	1.3	COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC	10.1038/s41467-023-40064-9
	643976	14524	None	29	Human	Functional	pAC50	=	4.9	4.9	-2	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	CHEMBL1201794	14524	None	29	Human	Functional	pAC50	=	4.9	4.9	-2	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	72093	35070	None	5	Human	Functional	pAC50	=	4.9	4.9	-10	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35070	None	5	Human	Functional	pAC50	=	4.9	4.9	-10	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35070	None	5	Human	Functional	pAC50	=	4.9	4.9	-10	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	65016	10211	None	50	Human	Functional	pAC50	=	4.9	4.9	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	505	11	3	7	2.4	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	CHEMBL116	10211	None	50	Human	Functional	pAC50	=	4.9	4.9	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	505	11	3	7	2.4	CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1	10.1038/s41467-023-40064-9
	22323	15305	None	29	Human	Functional	pAC50	=	4.9	4.9	-3	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15305	None	29	Human	Functional	pAC50	=	4.9	4.9	-3	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15305	None	29	Human	Functional	pAC50	=	4.9	4.9	-3	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	47319	26472	None	27	Human	Functional	pAC50	=	4.9	4.9	-4	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1360	26472	None	27	Human	Functional	pAC50	=	4.9	4.9	-4	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	929	24	0	12	8.1	COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC	10.1038/s41467-023-40064-9
	3191	102913	None	65	Human	Functional	pAC50	=	4.9	4.9	-660	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	3191.0	102913	None	65	Human	Functional	pAC50	=	4.9	4.9	-660	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL305660	102913	None	65	Human	Functional	pAC50	=	4.9	4.9	-660	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	DB11742	102913	None	65	Human	Functional	pAC50	=	4.9	4.9	-660	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	10.1038/s41467-023-40064-9
	2372	106524	None	30	Human	Functional	pAC50	=	4.9	4.9	-144	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106524	None	30	Human	Functional	pAC50	=	4.9	4.9	-144	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	216416	111644	None	40	Human	Functional	pAC50	=	4.9	4.9	-141	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111644	None	40	Human	Functional	pAC50	=	4.9	4.9	-141	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	23480	124157	None	21	Human	Functional	pAC50	=	4.9	4.9	-15	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL363295	124157	None	21	Human	Functional	pAC50	=	4.9	4.9	-15	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	5	1	1	5.0	CC(CC(c1ccccc1)c1ccccc1)NC(C)(C)C	10.1038/s41467-023-40064-9
	135412795	44765	None	17	Human	Functional	pAC50	=	4.9	4.9	-7	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
	CHEMBL1521495	44765	None	17	Human	Functional	pAC50	=	4.9	4.9	-7	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	1	1	3	3.4	O=C1CN=C(c2ccccc2)c2c(sc3c2CCCC3)N1	10.1038/s41467-023-40064-9
	2805	161984	None	27	Human	Functional	pAC50	=	5.9	5.9	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL415087	161984	None	27	Human	Functional	pAC50	=	5.9	5.9	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	3053	207592	None	64	Human	Functional	pAC50	=	5.9	5.9	1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL780	207592	None	64	Human	Functional	pAC50	=	5.9	5.9	1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	1024	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	5359318	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	5359318.0	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	556	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	65326	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	65326.0	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	9294.0	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL1523964	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL211456	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	CHEMBL2146102	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	DB01364	1571	None	12	Human	Functional	pAC50	=	4.9	4.9	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	165	3	2	2	1.3	CN[C@H]([C@@H](c1ccccc1)O)C	10.1038/s41467-023-40064-9
	119570	3159	None	58	Human	Functional	pAC50	=	4.9	4.9	-10000	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	119570.0	3159	None	58	Human	Functional	pAC50	=	4.9	4.9	-10000	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3159	None	58	Human	Functional	pAC50	=	4.9	4.9	-10000	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3159	None	58	Human	Functional	pAC50	=	4.9	4.9	-10000	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3159	None	58	Human	Functional	pAC50	=	4.9	4.9	-10000	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3159	None	58	Human	Functional	pAC50	=	4.9	4.9	-10000	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2782	32008	None	48	Human	Functional	pAC50	=	4.9	4.9	-3801	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL1407943	32008	None	48	Human	Functional	pAC50	=	4.9	4.9	-3801	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL3216363	32008	None	48	Human	Functional	pAC50	=	4.9	4.9	-3801	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	4528	98179	None	50	Human	Functional	pAC50	=	4.9	4.9	-181	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	CHEMBL273575	98179	None	50	Human	Functional	pAC50	=	4.9	4.9	-181	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	10.1038/s41467-023-40064-9
	5311017	120668	None	8	Human	Functional	pAC50	=	4.9	4.9	-13	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	5311017.0	120668	None	8	Human	Functional	pAC50	=	4.9	4.9	-13	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3545985	120668	None	8	Human	Functional	pAC50	=	4.9	4.9	-13	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00865	120668	None	8	Human	Functional	pAC50	=	4.9	4.9	-13	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	239	5	0	1	3.8	C[C@@H](Cc1ccccc1)N(C)Cc1ccccc1	10.1038/s41467-023-40064-9
	26248	161633	None	72	Human	Functional	pAC50	=	4.9	4.9	-1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161633	None	72	Human	Functional	pAC50	=	4.9	4.9	-1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	16119814	56359	None	20	Human	Functional	pAC50	=	4.9	4.9	-2	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	CHEMBL1630575	56359	None	20	Human	Functional	pAC50	=	4.9	4.9	-2	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
	443869	78170	None	28	Human	Functional	pAC50	=	5.9	5.9	1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2103761	78170	None	28	Human	Functional	pAC50	=	5.9	5.9	1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	68555	103167	None	14	Human	Functional	pAC50	=	6.9	6.9	-3	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	103167	None	14	Human	Functional	pAC50	=	6.9	6.9	-3	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	15942715	78222	None	18	Human	Functional	pAC50	=	4.9	4.9	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	5	1	5	4.0	CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL2105087	78222	None	18	Human	Functional	pAC50	=	4.9	4.9	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	446	5	1	5	4.0	CCCCOC(=O)C(=O)[C@H]1[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	6918178	14450	None	36	Human	Functional	pAC50	=	4.9	4.9	1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	484	4	1	5	4.1	CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1200908	14450	None	36	Human	Functional	pAC50	=	4.9	4.9	1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	484	4	1	5	4.1	CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C	10.1038/s41467-023-40064-9
	667492	43919	None	36	Human	Functional	pAC50	=	4.9	4.9	1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	234	1	2	3	0.2	CN1C(=O)/C(=N\NC(N)=S)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1512080	43919	None	36	Human	Functional	pAC50	=	4.9	4.9	1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	234	1	2	3	0.2	CN1C(=O)/C(=N\NC(N)=S)c2ccccc21	10.1038/s41467-023-40064-9
	3652	4097	None	50	Human	Functional	pAC50	=	4.9	4.9	-2089	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	57	4097	None	50	Human	Functional	pAC50	=	4.9	4.9	-2089	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809	4097	None	50	Human	Functional	pAC50	=	4.9	4.9	-2089	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	60809.0	4097	None	50	Human	Functional	pAC50	=	4.9	4.9	-2089	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	CHEMBL21536	4097	None	50	Human	Functional	pAC50	=	4.9	4.9	-2089	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	DB15357	4097	None	50	Human	Functional	pAC50	=	4.9	4.9	-2089	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
	213046	2385	None	44	Human	Functional	pAC50	=	6.9	6.9	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	213046.0	2385	None	44	Human	Functional	pAC50	=	6.9	6.9	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	None	44	Human	Functional	pAC50	=	6.9	6.9	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	None	44	Human	Functional	pAC50	=	6.9	6.9	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	None	44	Human	Functional	pAC50	=	6.9	6.9	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	None	44	Human	Functional	pAC50	=	6.9	6.9	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	3351	95055	None	40	Human	Functional	pAC50	=	4.9	4.9	-2	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
	CHEMBL254857	95055	None	40	Human	Functional	pAC50	=	4.9	4.9	-2	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	388	5	0	5	2.8	O=C(COc1ccc(Cl)cc1)N1CCN(Cc2ccc3c(c2)OCO3)CC1	10.1038/s41467-023-40064-9
	6917906	67795	None	17	Human	Functional	pAC50	=	4.9	4.9	-6	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	887	35	10	12	1.7	CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(N)=O)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1908331	67795	None	17	Human	Functional	pAC50	=	4.9	4.9	-6	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	887	35	10	12	1.7	CCCCCCCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)CC[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1NC(C)=O)C(N)=O)C(=O)O	10.1038/s41467-023-40064-9
	98941	46964	None	13	Human	Functional	pAC50	=	4.9	4.9	-66	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL154126	46964	None	13	Human	Functional	pAC50	=	4.9	4.9	-66	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL4743867	216518	None	10	Human	Functional	pAC50	=	4.9	4.9	-4466	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	3474	38112	None	43	Human	Functional	pAC50	=	4.9	4.9	-4	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	CHEMBL146095	38112	None	43	Human	Functional	pAC50	=	4.9	4.9	-4	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	6	3	6	3.1	O=C(OCC(O)CO)c1ccccc1Nc1ccnc2cc(Cl)ccc12	10.1038/s41467-023-40064-9
	49843517	78325	None	41	Human	Functional	pAC50	=	4.9	4.9	-40	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	CHEMBL2107831	78325	None	41	Human	Functional	pAC50	=	4.9	4.9	-40	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
	3103	41672	None	36	Human	Functional	pAC50	=	4.9	4.9	-138	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	3103.0	41672	None	36	Human	Functional	pAC50	=	4.9	4.9	-138	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1492	41672	None	36	Human	Functional	pAC50	=	4.9	4.9	-138	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB01146	41672	None	36	Human	Functional	pAC50	=	4.9	4.9	-138	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	16222096	80514	None	50	Human	Functional	pAC50	=	4.9	4.9	-50	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	CHEMBL2146883	80514	None	50	Human	Functional	pAC50	=	4.9	4.9	-50	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
	2580	78426	None	10	Human	Functional	pAC50	=	4.9	4.9	-660	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL2110775	78426	None	10	Human	Functional	pAC50	=	4.9	4.9	-660	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
	448537	160344	None	54	Human	Functional	pAC50	=	4.9	4.9	-54	31	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160344	None	54	Human	Functional	pAC50	=	4.9	4.9	-54	31	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	16362	3125	None	49	Human	Functional	pAC50	=	6.9	6.9	-14	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16362.0	3125	None	49	Human	Functional	pAC50	=	6.9	6.9	-14	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3125	None	49	Human	Functional	pAC50	=	6.9	6.9	-14	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3125	None	49	Human	Functional	pAC50	=	6.9	6.9	-14	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3125	None	49	Human	Functional	pAC50	=	6.9	6.9	-14	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3125	None	49	Human	Functional	pAC50	=	6.9	6.9	-14	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3634	84142	None	43	Human	Functional	pAC50	=	5.9	5.9	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL22077	84142	None	43	Human	Functional	pAC50	=	5.9	5.9	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	7	2	5	3.7	CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	3478	5428	None	61	Human	Functional	pAC50	=	4.9	4.9	-758	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	445	7	3	6	2.1	Cc1cnc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc2)cn1	10.1038/s41467-023-40064-9
	CHEMBL1073	5428	None	61	Human	Functional	pAC50	=	4.9	4.9	-758	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	445	7	3	6	2.1	Cc1cnc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NC3CCCCC3)cc2)cn1	10.1038/s41467-023-40064-9
	72287	61081	None	27	Human	Functional	pAC50	=	7.9	7.9	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	72287.0	61081	None	27	Human	Functional	pAC50	=	7.9	7.9	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1764	61081	None	27	Human	Functional	pAC50	=	7.9	7.9	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB01403	61081	None	27	Human	Functional	pAC50	=	7.9	7.9	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	19675	51685	None	37	Human	Functional	pAC50	=	6.9	6.9	-12	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51685	None	37	Human	Functional	pAC50	=	6.9	6.9	-12	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2284	3182	None	26	Human	Functional	pAC50	=	6.9	6.9	-3	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3182	None	26	Human	Functional	pAC50	=	6.9	6.9	-3	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3182	None	26	Human	Functional	pAC50	=	6.9	6.9	-3	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3182	None	26	Human	Functional	pAC50	=	6.9	6.9	-3	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3182	None	26	Human	Functional	pAC50	=	6.9	6.9	-3	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	2398	954	None	43	Human	Functional	pAC50	=	5.9	5.9	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	954	None	43	Human	Functional	pAC50	=	5.9	5.9	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801.0	954	None	43	Human	Functional	pAC50	=	5.9	5.9	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	954	None	43	Human	Functional	pAC50	=	5.9	5.9	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	954	None	43	Human	Functional	pAC50	=	5.9	5.9	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	954	None	43	Human	Functional	pAC50	=	5.9	5.9	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	55483	207555	None	29	Human	Functional	pAC50	=	5.9	5.9	-8	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	CHEMBL77622	207555	None	29	Human	Functional	pAC50	=	5.9	5.9	-8	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	2869	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	60857.0	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL1185	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	DB00315	4152	None	54	Human	Functional	pAC50	=	4.9	4.9	-5011	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1038/s41467-023-40064-9
	4762	14475	None	14	Human	Functional	pAC50	=	4.9	4.9	1	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201208	14475	None	14	Human	Functional	pAC50	=	4.9	4.9	1	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	5556	205718	None	15	Human	Functional	pAC50	=	4.9	4.9	-33	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	342	1	0	4	4.2	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2	10.1038/s41467-023-40064-9
	CHEMBL646	205718	None	15	Human	Functional	pAC50	=	4.9	4.9	-33	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	342	1	0	4	4.2	Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2	10.1038/s41467-023-40064-9
	2218	15289	None	20	Human	Functional	pAC50	=	4.9	4.9	-5	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1213033	15289	None	20	Human	Functional	pAC50	=	4.9	4.9	-5	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	8	0	2	4.4	CCN(CC)CCCN(c1ccccc1)C1Cc2ccccc2C1	10.1038/s41467-023-40064-9
	2780	110592	None	24	Human	Functional	pAC50	=	4.9	4.9	-1479	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2780.0	110592	None	24	Human	Functional	pAC50	=	4.9	4.9	-1479	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110592	None	24	Human	Functional	pAC50	=	4.9	4.9	-1479	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13511	110592	None	24	Human	Functional	pAC50	=	4.9	4.9	-1479	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	9417	133581	None	40	Human	Functional	pAC50	=	4.9	4.9	-33	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL1524185	133581	None	40	Human	Functional	pAC50	=	4.9	4.9	-33	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL370753	133581	None	40	Human	Functional	pAC50	=	4.9	4.9	-33	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
	5365247	138516	None	29	Human	Functional	pAC50	=	4.9	4.9	-100	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	CHEMBL37744	138516	None	29	Human	Functional	pAC50	=	4.9	4.9	-100	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	316	4	0	2	3.8	CN(C)C/C=C(/c1ccc(Br)cc1)c1cccnc1	10.1038/s41467-023-40064-9
	2318	154946	None	18	Human	Functional	pAC50	=	4.9	4.9	-20	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154946	None	18	Human	Functional	pAC50	=	4.9	4.9	-20	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	2771	197264	None	50	Human	Functional	pAC50	=	4.9	4.9	-46	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	197264	None	50	Human	Functional	pAC50	=	4.9	4.9	-46	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	197264	None	50	Human	Functional	pAC50	=	4.9	4.9	-46	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	3950	189617	None	67	Human	Functional	pAC50	=	4.9	4.9	-4	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL514	189617	None	67	Human	Functional	pAC50	=	4.9	4.9	-4	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	233	4	1	3	2.3	O=NN(CCCl)C(=O)NC1CCCCC1	10.1038/s41467-023-40064-9
	37	778	None	41	Human	Functional	pAC50	=	6.9	6.9	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	None	41	Human	Functional	pAC50	=	6.9	6.9	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	None	41	Human	Functional	pAC50	=	6.9	6.9	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746.0	778	None	41	Human	Functional	pAC50	=	6.9	6.9	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	None	41	Human	Functional	pAC50	=	6.9	6.9	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	None	41	Human	Functional	pAC50	=	6.9	6.9	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	1599	2341	None	28	Human	Functional	pAC50	=	4.9	4.9	-7585	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955	2341	None	28	Human	Functional	pAC50	=	4.9	4.9	-7585	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	3955.0	2341	None	28	Human	Functional	pAC50	=	4.9	4.9	-7585	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7215	2341	None	28	Human	Functional	pAC50	=	4.9	4.9	-7585	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL841	2341	None	28	Human	Functional	pAC50	=	4.9	4.9	-7585	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00836	2341	None	28	Human	Functional	pAC50	=	4.9	4.9	-7585	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2723	154135	None	63	Human	Functional	pAC50	=	4.9	4.9	-7	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL398440	154135	None	63	Human	Functional	pAC50	=	4.9	4.9	-7	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Functional	pAC50	=	6.8	6.8	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Functional	pAC50	=	6.8	6.8	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Functional	pAC50	=	6.8	6.8	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Functional	pAC50	=	6.8	6.8	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Functional	pAC50	=	6.8	6.8	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Functional	pAC50	=	6.8	6.8	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	5351322	94844	None	30	Human	Functional	pAC50	=	5.8	5.8	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL25336	94844	None	30	Human	Functional	pAC50	=	5.8	5.8	1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
	3117	210300	None	60	Human	Functional	pAC50	=	4.8	4.8	-20	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
	CHEMBL964	210300	None	60	Human	Functional	pAC50	=	4.8	4.8	-20	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
	9818306	14424	None	13	Human	Functional	pAC50	=	4.8	4.8	-2	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	1	3	3.8	CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1200430	14424	None	13	Human	Functional	pAC50	=	4.8	4.8	-2	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	1	3	3.8	CC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)CC[C@@H]12	10.1038/s41467-023-40064-9
	2398	954	None	43	Human	Functional	pAC50	=	7.8	7.8	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	954	None	43	Human	Functional	pAC50	=	7.8	7.8	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801.0	954	None	43	Human	Functional	pAC50	=	7.8	7.8	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	954	None	43	Human	Functional	pAC50	=	7.8	7.8	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	954	None	43	Human	Functional	pAC50	=	7.8	7.8	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	954	None	43	Human	Functional	pAC50	=	7.8	7.8	-72	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2337	3256	None	51	Human	Functional	pAC50	=	6.8	6.8	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	None	51	Human	Functional	pAC50	=	6.8	6.8	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	None	51	Human	Functional	pAC50	=	6.8	6.8	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002.0	3256	None	51	Human	Functional	pAC50	=	6.8	6.8	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	None	51	Human	Functional	pAC50	=	6.8	6.8	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	None	51	Human	Functional	pAC50	=	6.8	6.8	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	1530	2182	None	36	Human	Functional	pAC50	=	4.8	4.8	-912	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2182	None	36	Human	Functional	pAC50	=	4.8	4.8	-912	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827.0	2182	None	36	Human	Functional	pAC50	=	4.8	4.8	-912	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2182	None	36	Human	Functional	pAC50	=	4.8	4.8	-912	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2182	None	36	Human	Functional	pAC50	=	4.8	4.8	-912	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2182	None	36	Human	Functional	pAC50	=	4.8	4.8	-912	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	243	3202	None	61	Human	Functional	pAC50	=	4.8	4.8	-1288	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	3052762	3202	None	61	Human	Functional	pAC50	=	4.8	4.8	-1288	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	3052762.0	3202	None	61	Human	Functional	pAC50	=	4.8	4.8	-1288	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	3502	3202	None	61	Human	Functional	pAC50	=	4.8	4.8	-1288	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	CHEMBL117287	3202	None	61	Human	Functional	pAC50	=	4.8	4.8	-1288	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	DB06480	3202	None	61	Human	Functional	pAC50	=	4.8	4.8	-1288	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	10.1038/s41467-023-40064-9
	2351	4301	None	35	Human	Functional	pAC50	=	4.8	4.8	-3	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4301	None	35	Human	Functional	pAC50	=	4.8	4.8	-3	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4301	None	35	Human	Functional	pAC50	=	4.8	4.8	-3	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	21772	78430	None	26	Human	Functional	pAC50	=	4.8	4.8	-1000	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	CHEMBL2110816	78430	None	26	Human	Functional	pAC50	=	4.8	4.8	-1000	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	293	4	0	1	4.5	CC(CC1c2ccccc2CCc2ccccc21)CN(C)C	10.1038/s41467-023-40064-9
	4413	98126	None	43	Human	Functional	pAC50	=	4.8	4.8	-4	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98126	None	43	Human	Functional	pAC50	=	4.8	4.8	-4	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	60151560	167540	None	37	Human	Functional	pAC50	=	4.8	4.8	-1	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	439	11	1	5	5.3	CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL4297530	167540	None	37	Human	Functional	pAC50	=	4.8	4.8	-1	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	439	11	1	5	5.3	CCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O	10.1038/s41467-023-40064-9
	216239	23803	None	71	Human	Functional	pAC50	=	4.8	4.8	-8	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23803	None	71	Human	Functional	pAC50	=	4.8	4.8	-8	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23803	None	71	Human	Functional	pAC50	=	4.8	4.8	-8	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	1830	2590	None	33	Human	Functional	pAC50	=	4.8	4.8	-416	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2590	None	33	Human	Functional	pAC50	=	4.8	4.8	-416	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2590	None	33	Human	Functional	pAC50	=	4.8	4.8	-416	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897.0	2590	None	33	Human	Functional	pAC50	=	4.8	4.8	-416	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2590	None	33	Human	Functional	pAC50	=	4.8	4.8	-416	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2590	None	33	Human	Functional	pAC50	=	4.8	4.8	-416	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	196122	112651	None	39	Human	Functional	pAC50	=	4.8	4.8	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	478	13	1	6	4.5	CCOC1O[C@H]([C@@H](COCc2ccccc2)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL3301681	112651	None	39	Human	Functional	pAC50	=	4.8	4.8	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	478	13	1	6	4.5	CCOC1O[C@H]([C@@H](COCc2ccccc2)OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1O	10.1038/s41467-023-40064-9
	392622	56328	None	57	Human	Functional	pAC50	=	4.8	4.8	-8	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56328	None	57	Human	Functional	pAC50	=	4.8	4.8	-8	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	1570	57315	None	64	Human	Functional	pAC50	=	5.8	5.8	2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	127	0	1	3	1.5	On1ccccc1=S	10.1038/s41467-023-40064-9
	CHEMBL1650619	57315	None	64	Human	Functional	pAC50	=	5.8	5.8	2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	127	0	1	3	1.5	On1ccccc1=S	10.1038/s41467-023-40064-9
	1548955	88615	None	14	Human	Functional	pAC50	=	4.8	4.8	-43	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2800	88615	None	14	Human	Functional	pAC50	=	4.8	4.8	-43	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL2355051	88615	None	14	Human	Functional	pAC50	=	4.8	4.8	-43	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	1155	1629	None	38	Human	Functional	pAC50	=	5.8	5.8	-363	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	3343	1629	None	38	Human	Functional	pAC50	=	5.8	5.8	-363	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	557	1629	None	38	Human	Functional	pAC50	=	5.8	5.8	-363	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL32800	1629	None	38	Human	Functional	pAC50	=	5.8	5.8	-363	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	DB01288	1629	None	38	Human	Functional	pAC50	=	5.8	5.8	-363	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	9270	14435	None	44	Human	Functional	pAC50	=	4.8	4.8	-5	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	384	2	0	4	4.4	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C[C@@H](OC(C)=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1200624	14435	None	44	Human	Functional	pAC50	=	4.8	4.8	-5	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	384	2	0	4	4.4	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C[C@@H](OC(C)=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Functional	pAC50	=	6.8	6.8	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Functional	pAC50	=	6.8	6.8	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Functional	pAC50	=	6.8	6.8	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Functional	pAC50	=	6.8	6.8	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	60663	175773	None	30	Human	Functional	pAC50	=	5.8	5.8	-8	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1421212	175773	None	30	Human	Functional	pAC50	=	5.8	5.8	-8	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1534525	175773	None	30	Human	Functional	pAC50	=	5.8	5.8	-8	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL45816	175773	None	30	Human	Functional	pAC50	=	5.8	5.8	-8	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	5994	4643	None	51	Human	Functional	pAC50	=	4.8	4.8	-5	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4643	None	51	Human	Functional	pAC50	=	4.8	4.8	-5	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	4034	55838	None	37	Human	Functional	pAC50	=	4.8	4.8	-12	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	4034.0	55838	None	37	Human	Functional	pAC50	=	4.8	4.8	-12	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55838	None	37	Human	Functional	pAC50	=	4.8	4.8	-12	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	DB00737	55838	None	37	Human	Functional	pAC50	=	4.8	4.8	-12	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	441383	20340	None	41	Human	Functional	pAC50	=	4.8	4.8	-165	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1306	20340	None	41	Human	Functional	pAC50	=	4.8	4.8	-165	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	5.8	5.8	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	5.8	5.8	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	5.8	5.8	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	5.8	5.8	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	5.8	5.8	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5440	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-1995	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5440.0	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-1995	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-1995	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB00372	28732	None	28	Human	Functional	pAC50	=	5.8	5.8	-1995	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	3926	209699	None	30	Human	Functional	pAC50	=	5.8	5.8	-2	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	209699	None	30	Human	Functional	pAC50	=	5.8	5.8	-2	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	31703	194829	None	40	Human	Functional	pAC50	=	4.8	4.8	-25	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194829	None	40	Human	Functional	pAC50	=	4.8	4.8	-25	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194829	None	40	Human	Functional	pAC50	=	4.8	4.8	-25	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	24826799	10802	None	64	Human	Functional	pAC50	=	4.8	4.8	-50	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10802	None	64	Human	Functional	pAC50	=	4.8	4.8	-50	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	2162	41527	None	58	Human	Functional	pAC50	=	4.8	4.8	-5	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41527	None	58	Human	Functional	pAC50	=	4.8	4.8	-5	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	5584	205669	None	29	Human	Functional	pAC50	=	6.8	6.8	-9	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	5584.0	205669	None	29	Human	Functional	pAC50	=	6.8	6.8	-9	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL644	205669	None	29	Human	Functional	pAC50	=	6.8	6.8	-9	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB00726	205669	None	29	Human	Functional	pAC50	=	6.8	6.8	-9	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	4735	197545	None	57	Human	Functional	pAC50	=	4.8	4.8	-199	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL361506	197545	None	57	Human	Functional	pAC50	=	4.8	4.8	-199	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL55	197545	None	57	Human	Functional	pAC50	=	4.8	4.8	-199	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL508338	189074	None	0	Human	Functional	pAC50	=	4.8	4.8	-181	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	1712	2492	None	34	Human	Functional	pAC50	=	7.8	7.8	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078	2492	None	34	Human	Functional	pAC50	=	7.8	7.8	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	4078.0	2492	None	34	Human	Functional	pAC50	=	7.8	7.8	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	7227	2492	None	34	Human	Functional	pAC50	=	7.8	7.8	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	CHEMBL1088	2492	None	34	Human	Functional	pAC50	=	7.8	7.8	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	DB00933	2492	None	34	Human	Functional	pAC50	=	7.8	7.8	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
	2865	4143	None	47	Human	Functional	pAC50	=	7.8	7.8	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	None	47	Human	Functional	pAC50	=	7.8	7.8	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	None	47	Human	Functional	pAC50	=	7.8	7.8	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854.0	4143	None	47	Human	Functional	pAC50	=	7.8	7.8	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	None	47	Human	Functional	pAC50	=	7.8	7.8	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	None	47	Human	Functional	pAC50	=	7.8	7.8	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	10531	1420	None	13	Human	Functional	pAC50	=	5.8	5.8	-301	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	10531.0	1420	None	13	Human	Functional	pAC50	=	5.8	5.8	-301	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	None	13	Human	Functional	pAC50	=	5.8	5.8	-301	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	None	13	Human	Functional	pAC50	=	5.8	5.8	-301	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	None	13	Human	Functional	pAC50	=	5.8	5.8	-301	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	None	13	Human	Functional	pAC50	=	5.8	5.8	-301	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2286	3183	None	36	Human	Functional	pAC50	=	5.8	5.8	-37	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	None	36	Human	Functional	pAC50	=	5.8	5.8	-37	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927.0	3183	None	36	Human	Functional	pAC50	=	5.8	5.8	-37	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	None	36	Human	Functional	pAC50	=	5.8	5.8	-37	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	None	36	Human	Functional	pAC50	=	5.8	5.8	-37	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	None	36	Human	Functional	pAC50	=	5.8	5.8	-37	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	56959	31564	None	60	Human	Functional	pAC50	=	5.8	5.8	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31564	None	60	Human	Functional	pAC50	=	5.8	5.8	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31564	None	60	Human	Functional	pAC50	=	5.8	5.8	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	213	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-5	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-5	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-5	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533.0	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-5	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-5	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	None	34	Human	Functional	pAC50	=	5.8	5.8	-5	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	6231	29778	None	23	Human	Functional	pAC50	=	4.8	4.8	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	0	1	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1387	29778	None	23	Human	Functional	pAC50	=	4.8	4.8	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	0	1	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=C(CCC(=O)C4)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Functional	pAC50	=	4.8	4.8	-26	42	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Functional	pAC50	=	4.8	4.8	-26	42	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Functional	pAC50	=	4.8	4.8	-26	42	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Functional	pAC50	=	4.8	4.8	-26	42	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Functional	pAC50	=	4.8	4.8	-26	42	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	10180	98923	None	36	Human	Functional	pAC50	=	4.8	4.8	-33	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	CHEMBL279014	98923	None	36	Human	Functional	pAC50	=	4.8	4.8	-33	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
	9324	9240	None	40	Human	Functional	pAC50	=	4.8	4.8	-3	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL110691	9240	None	40	Human	Functional	pAC50	=	4.8	4.8	-3	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	2	0	4	4.8	CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	1662	188812	None	53	Human	Functional	pAC50	=	4.8	4.8	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	162	4	3	3	-0.3	CC(O)(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL50444	188812	None	53	Human	Functional	pAC50	=	4.8	4.8	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	162	4	3	3	-0.3	CC(O)(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
	25151352	140693	None	56	Human	Functional	pAC50	=	5.8	5.8	-4	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	CHEMBL3813873	140693	None	56	Human	Functional	pAC50	=	5.8	5.8	-4	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-35	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-35	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-35	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.8	4.8	-35	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	54454	5260	None	48	Human	Functional	pAC50	=	4.7	4.7	-7	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5260	None	48	Human	Functional	pAC50	=	4.7	4.7	-7	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	9822750	78440	None	44	Human	Functional	pAC50	=	4.7	4.7	-4	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL2111097	78440	None	44	Human	Functional	pAC50	=	4.7	4.7	-4	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
	119369	2606	None	50	Human	Functional	pAC50	=	4.7	4.7	-602	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	2197	2606	None	50	Human	Functional	pAC50	=	4.7	4.7	-602	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	4004	2606	None	50	Human	Functional	pAC50	=	4.7	4.7	-602	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL420762	2606	None	50	Human	Functional	pAC50	=	4.7	4.7	-602	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	4	1	3	5.3	O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	2005	78259	None	59	Human	Functional	pAC50	=	4.7	4.7	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	173	6	2	2	0.8	CC(=O)NCCCCCC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL2105922	78259	None	59	Human	Functional	pAC50	=	4.7	4.7	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	173	6	2	2	0.8	CC(=O)NCCCCCC(=O)O	10.1038/s41467-023-40064-9
	2162	41527	None	58	Human	Functional	pAC50	=	5.7	5.7	-5	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41527	None	58	Human	Functional	pAC50	=	5.7	5.7	-5	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	12555	17968	None	39	Human	Functional	pAC50	=	4.7	4.7	-38	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL12610	17968	None	39	Human	Functional	pAC50	=	4.7	4.7	-38	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
	10133	910	None	49	Human	Functional	pAC50	=	4.7	4.7	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	145714624	910	None	49	Human	Functional	pAC50	=	4.7	4.7	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	4361	910	None	49	Human	Functional	pAC50	=	4.7	4.7	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	608	910	None	49	Human	Functional	pAC50	=	4.7	4.7	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL240597	910	None	49	Human	Functional	pAC50	=	4.7	4.7	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	DB06777	910	None	49	Human	Functional	pAC50	=	4.7	4.7	-6	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	4	3	3	4.5	O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C	10.1038/s41467-023-40064-9
	657202	12534	None	3	Human	Functional	pAC50	=	4.7	4.7	-524	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1186610	12534	None	3	Human	Functional	pAC50	=	4.7	4.7	-524	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	282	6	0	2	3.5	CCCC(CCC)C(=O)O[C@H]1C[C@H]2CC[C@@H](C1)[N+]2(C)C	10.1038/s41467-023-40064-9
	9911830	19155	None	57	Human	Functional	pAC50	=	4.7	4.7	1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1289494	19155	None	57	Human	Functional	pAC50	=	4.7	4.7	1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	454	6	2	7	5.6	COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC	10.1038/s41467-023-40064-9
	5281718	34259	None	55	Human	Functional	pAC50	=	4.7	4.7	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	6	8	0.4	OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL142652	34259	None	55	Human	Functional	pAC50	=	4.7	4.7	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	5	6	8	0.4	OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	4041	99565	None	9	Human	Functional	pAC50	=	4.7	4.7	-19	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	1	0	2	3.6	CN1CCN=C(c2ccccc2)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	CHEMBL28333	99565	None	9	Human	Functional	pAC50	=	4.7	4.7	-19	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	1	0	2	3.6	CN1CCN=C(c2ccccc2)c2cc(Cl)ccc21	10.1038/s41467-023-40064-9
	2695	3841	None	53	Human	Functional	pAC50	=	5.7	5.7	-2	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	5504	3841	None	53	Human	Functional	pAC50	=	5.7	5.7	-2	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	7310	3841	None	53	Human	Functional	pAC50	=	5.7	5.7	-2	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL770	3841	None	53	Human	Functional	pAC50	=	5.7	5.7	-2	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00797	3841	None	53	Human	Functional	pAC50	=	5.7	5.7	-2	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	160	2	1	2	1.2	c1ccc(cc1)CC1=NCCN1	10.1038/s41467-023-40064-9
	45138674	16653	None	45	Human	Functional	pAC50	=	5.7	5.7	1	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16653	None	45	Human	Functional	pAC50	=	5.7	5.7	1	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	8569	22651	None	59	Human	Functional	pAC50	=	4.7	4.7	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	244	3	2	4	2.3	COc1ccc(C(=O)c2ccccc2O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1326877	22651	None	59	Human	Functional	pAC50	=	4.7	4.7	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	244	3	2	4	2.3	COc1ccc(C(=O)c2ccccc2O)c(O)c1	10.1038/s41467-023-40064-9
	24821094	67115	None	58	Human	Functional	pAC50	=	4.7	4.7	-6	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67115	None	58	Human	Functional	pAC50	=	4.7	4.7	-6	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	3658	4107	None	38	Human	Functional	pAC50	=	8.6	8.6	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	None	38	Human	Functional	pAC50	=	8.6	8.6	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	None	38	Human	Functional	pAC50	=	8.6	8.6	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709.0	4107	None	38	Human	Functional	pAC50	=	8.6	8.6	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	None	38	Human	Functional	pAC50	=	8.6	8.6	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	None	38	Human	Functional	pAC50	=	8.6	8.6	1	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	1028	291	None	40	Human	Functional	pAC50	=	8.6	8.6	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	None	40	Human	Functional	pAC50	=	8.6	8.6	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	None	40	Human	Functional	pAC50	=	8.6	8.6	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	None	40	Human	Functional	pAC50	=	8.6	8.6	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816.0	291	None	40	Human	Functional	pAC50	=	8.6	8.6	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	None	40	Human	Functional	pAC50	=	8.6	8.6	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	None	40	Human	Functional	pAC50	=	8.6	8.6	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2146	3100	None	45	Human	Functional	pAC50	=	8.6	8.6	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3100	None	45	Human	Functional	pAC50	=	8.6	8.6	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3100	None	45	Human	Functional	pAC50	=	8.6	8.6	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041.0	3100	None	45	Human	Functional	pAC50	=	8.6	8.6	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3100	None	45	Human	Functional	pAC50	=	8.6	8.6	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3100	None	45	Human	Functional	pAC50	=	8.6	8.6	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	4151	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	493	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125.0	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL24778	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	DB06207	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	150	2509	None	14	Human	Functional	pAC50	=	7.7	7.7	-194	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	None	14	Human	Functional	pAC50	=	7.7	7.7	-194	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	None	14	Human	Functional	pAC50	=	7.7	7.7	-194	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226.0	2509	None	14	Human	Functional	pAC50	=	7.7	7.7	-194	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	None	14	Human	Functional	pAC50	=	7.7	7.7	-194	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	None	14	Human	Functional	pAC50	=	7.7	7.7	-194	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Functional	pAC50	=	7.7	7.7	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Functional	pAC50	=	7.7	7.7	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Functional	pAC50	=	7.7	7.7	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Functional	pAC50	=	7.7	7.7	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Functional	pAC50	=	7.7	7.7	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Functional	pAC50	=	7.7	7.7	-17	43	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	31729	208242	None	9	Human	Functional	pAC50	=	5.7	5.7	-131	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL83063	208242	None	9	Human	Functional	pAC50	=	5.7	5.7	-131	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	6	4	4	2.4	CC(NCCc1ccc(O)cc1)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	202	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-3	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-3	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-3	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-3	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	None	46	Human	Functional	pAC50	=	4.7	4.7	-3	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	448537	160344	None	54	Human	Functional	pAC50	=	4.7	4.7	-54	31	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160344	None	54	Human	Functional	pAC50	=	4.7	4.7	-54	31	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	3035016	12598	None	44	Human	Functional	pAC50	=	4.7	4.7	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	3	5	10	0.6	CC(=O)[C@]1(N)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](O)[C@H](O)CO2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	CHEMBL1186894	12598	None	44	Human	Functional	pAC50	=	4.7	4.7	-1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	3	5	10	0.6	CC(=O)[C@]1(N)Cc2c(O)c3c(c(O)c2[C@@H](O[C@H]2C[C@H](O)[C@H](O)CO2)C1)C(=O)c1ccccc1C3=O	10.1038/s41467-023-40064-9
	89683805	154523	None	55	Human	Functional	pAC50	=	4.7	4.7	-6760	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	473	6	3	8	4.3	CC(C)(O)CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1	10.1038/s41467-023-40064-9
	CHEMBL3989908	154523	None	55	Human	Functional	pAC50	=	4.7	4.7	-6760	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	473	6	3	8	4.3	CC(C)(O)CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1	10.1038/s41467-023-40064-9
	44439	165782	None	16	Human	Functional	pAC50	=	4.7	4.7	-63	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	377	9	3	5	2.8	COc1ccc(CCC(C)NCC(O)c2ccc(O)c([S+](C)[O-])c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL424518	165782	None	16	Human	Functional	pAC50	=	4.7	4.7	-63	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	377	9	3	5	2.8	COc1ccc(CCC(C)NCC(O)c2ccc(O)c([S+](C)[O-])c2)cc1	10.1038/s41467-023-40064-9
	444795	140086	None	62	Human	Functional	pAC50	=	4.7	4.7	-57	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	10.1038/s41467-023-40064-9
	CHEMBL38	140086	None	62	Human	Functional	pAC50	=	4.7	4.7	-57	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	10.1038/s41467-023-40064-9
	5489013	57421	None	24	Human	Functional	pAC50	=	6.7	6.7	-21	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
	CHEMBL1651913	57421	None	24	Human	Functional	pAC50	=	6.7	6.7	-21	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
	1923	104780	None	79	Human	Functional	pAC50	=	4.7	4.7	-3	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	145	0	1	2	1.9	Oc1cccc2cccnc12	10.1038/s41467-023-40064-9
	CHEMBL310555	104780	None	79	Human	Functional	pAC50	=	4.7	4.7	-3	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	145	0	1	2	1.9	Oc1cccc2cccnc12	10.1038/s41467-023-40064-9
	1753	2504	None	16	Human	Functional	pAC50	=	7.7	7.7	2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	483	2504	None	16	Human	Functional	pAC50	=	7.7	7.7	2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	6082	2504	None	16	Human	Functional	pAC50	=	7.7	7.7	2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	6082.0	2504	None	16	Human	Functional	pAC50	=	7.7	7.7	2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	CHEMBL524	2504	None	16	Human	Functional	pAC50	=	7.7	7.7	2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	DB00723	2504	None	16	Human	Functional	pAC50	=	7.7	7.7	2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1038/s41467-023-40064-9
	2726	919	None	48	Human	Functional	pAC50	=	6.7	6.7	-29	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2726.0	919	None	48	Human	Functional	pAC50	=	6.7	6.7	-29	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	None	48	Human	Functional	pAC50	=	6.7	6.7	-29	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	None	48	Human	Functional	pAC50	=	6.7	6.7	-29	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	None	48	Human	Functional	pAC50	=	6.7	6.7	-29	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	None	48	Human	Functional	pAC50	=	6.7	6.7	-29	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	135409453	3773	None	26	Human	Functional	pAC50	=	5.7	5.7	-363	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	None	26	Human	Functional	pAC50	=	5.7	5.7	-363	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	None	26	Human	Functional	pAC50	=	5.7	5.7	-363	35	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	214	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-22	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-22	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-22	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566.0	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-22	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-22	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-22	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-22	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	26248	161633	None	72	Human	Functional	pAC50	=	4.7	4.7	-1	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	CHEMBL41286	161633	None	72	Human	Functional	pAC50	=	4.7	4.7	-1	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	368	3	1	7	2.0	CC(=O)Oc1cccc2c1C(=O)c1c(OC(C)=O)cc(C(=O)O)cc1C2=O	10.1038/s41467-023-40064-9
	11289	14443	None	47	Human	Functional	pAC50	=	4.7	4.7	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	380	6	0	3	5.9	COc1ccc(C(Cl)=C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1200761	14443	None	47	Human	Functional	pAC50	=	4.7	4.7	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	380	6	0	3	5.9	COc1ccc(C(Cl)=C(c2ccc(OC)cc2)c2ccc(OC)cc2)cc1	10.1038/s41467-023-40064-9
	2880	98061	None	34	Human	Functional	pAC50	=	4.7	4.7	-13	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL27289	98061	None	34	Human	Functional	pAC50	=	4.7	4.7	-13	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	3356	205826	None	57	Human	Functional	pAC50	=	4.7	4.7	-33	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	7	2	4	3.4	O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1200822	205826	None	57	Human	Functional	pAC50	=	4.7	4.7	-33	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	7	2	4	3.4	O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL652	205826	None	57	Human	Functional	pAC50	=	4.7	4.7	-33	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	7	2	4	3.4	O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F	10.1038/s41467-023-40064-9
	54684141	210459	None	52	Human	Functional	pAC50	=	4.7	4.7	1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL973	210459	None	52	Human	Functional	pAC50	=	4.7	4.7	1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	270	2	2	3	3.0	C/C(O)=C(\C#N)C(=O)Nc1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	1499	2091	None	34	Human	Functional	pAC50	=	5.7	5.7	-44668	38	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	3779	2091	None	34	Human	Functional	pAC50	=	5.7	5.7	-44668	38	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	3779.0	2091	None	34	Human	Functional	pAC50	=	5.7	5.7	-44668	38	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	536	2091	None	34	Human	Functional	pAC50	=	5.7	5.7	-44668	38	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	CHEMBL434	2091	None	34	Human	Functional	pAC50	=	5.7	5.7	-44668	38	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	DB01064	2091	None	34	Human	Functional	pAC50	=	5.7	5.7	-44668	38	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	211	4	4	4	1.1	CC(NCC(c1ccc(c(c1)O)O)O)C	10.1038/s41467-023-40064-9
	16564	207453	None	20	Human	Functional	pAC50	=	4.7	4.7	-144	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
	CHEMBL76725	207453	None	20	Human	Functional	pAC50	=	4.7	4.7	-144	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
	2028	2979	None	52	Human	Functional	pAC50	=	4.7	4.7	-10715	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	359	2979	None	52	Human	Functional	pAC50	=	4.7	4.7	-10715	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	4634	2979	None	52	Human	Functional	pAC50	=	4.7	4.7	-10715	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	4634.0	2979	None	52	Human	Functional	pAC50	=	4.7	4.7	-10715	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	CHEMBL1231	2979	None	52	Human	Functional	pAC50	=	4.7	4.7	-10715	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	DB01062	2979	None	52	Human	Functional	pAC50	=	4.7	4.7	-10715	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	10.1038/s41467-023-40064-9
	34040	28093	None	52	Human	Functional	pAC50	=	4.7	4.7	-7244	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	34040.0	28093	None	52	Human	Functional	pAC50	=	4.7	4.7	-7244	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	CHEMBL1372950	28093	None	52	Human	Functional	pAC50	=	4.7	4.7	-7244	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	DB00699	28093	None	52	Human	Functional	pAC50	=	4.7	4.7	-7244	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
	3081361	93987	None	66	Human	Functional	pAC50	=	4.7	4.7	-35	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93987	None	66	Human	Functional	pAC50	=	4.7	4.7	-35	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	5344	173577	None	67	Human	Functional	pAC50	=	4.7	4.7	-3981	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	10.1038/s41467-023-40064-9
	CHEMBL453	173577	None	67	Human	Functional	pAC50	=	4.7	4.7	-3981	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	267	3	2	5	1.7	Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C	10.1038/s41467-023-40064-9
	3157	1470	None	44	Human	Functional	pAC50	=	7.7	7.7	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	3157.0	1470	None	44	Human	Functional	pAC50	=	7.7	7.7	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	None	44	Human	Functional	pAC50	=	7.7	7.7	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	None	44	Human	Functional	pAC50	=	7.7	7.7	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	None	44	Human	Functional	pAC50	=	7.7	7.7	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	None	44	Human	Functional	pAC50	=	7.7	7.7	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	2142	3096	None	36	Human	Functional	pAC50	=	6.7	6.7	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3096	None	36	Human	Functional	pAC50	=	6.7	6.7	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3096	None	36	Human	Functional	pAC50	=	6.7	6.7	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3096	None	36	Human	Functional	pAC50	=	6.7	6.7	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775.0	3096	None	36	Human	Functional	pAC50	=	6.7	6.7	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3096	None	36	Human	Functional	pAC50	=	6.7	6.7	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3096	None	36	Human	Functional	pAC50	=	6.7	6.7	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	1890	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-4	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-4	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-4	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-4	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	None	31	Human	Functional	pAC50	=	5.7	5.7	-4	28	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	10453870	73688	None	45	Human	Functional	pAC50	=	4.7	4.7	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	4	4	6	2.1	OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL2018096	73688	None	45	Human	Functional	pAC50	=	4.7	4.7	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	4	4	6	2.1	OC[C@H]1O[C@@H](c2ccc(F)c(Cc3cc4ccccc4s3)c2)[C@H](O)[C@@H](O)[C@@H]1O	10.1038/s41467-023-40064-9
	9419	35931	None	28	Human	Functional	pAC50	=	4.7	4.7	-72	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	9419.0	35931	None	28	Human	Functional	pAC50	=	4.7	4.7	-72	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1442422	35931	None	28	Human	Functional	pAC50	=	4.7	4.7	-72	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	DB13225	35931	None	28	Human	Functional	pAC50	=	4.7	4.7	-72	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	4601	209205	None	27	Human	Functional	pAC50	=	4.6	4.6	-1148	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	4601.0	209205	None	27	Human	Functional	pAC50	=	4.6	4.6	-1148	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201023	209205	None	27	Human	Functional	pAC50	=	4.6	4.6	-1148	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL900	209205	None	27	Human	Functional	pAC50	=	4.6	4.6	-1148	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	DB01173	209205	None	27	Human	Functional	pAC50	=	4.6	4.6	-1148	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
	8609	14449	None	44	Human	Functional	pAC50	=	4.6	4.6	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	229	2	2	4	2.2	Nc1ccc(C(=O)Oc2ccccc2)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1200868	14449	None	44	Human	Functional	pAC50	=	4.6	4.6	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	229	2	2	4	2.2	Nc1ccc(C(=O)Oc2ccccc2)c(O)c1	10.1038/s41467-023-40064-9
	5205	78216	None	42	Human	Functional	pAC50	=	6.6	6.6	-2	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL2104895	78216	None	42	Human	Functional	pAC50	=	6.6	6.6	-2	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
	1209	1658	None	52	Human	Functional	pAC50	=	4.6	4.6	-91	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	None	52	Human	Functional	pAC50	=	4.6	4.6	-91	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	None	52	Human	Functional	pAC50	=	4.6	4.6	-91	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	None	52	Human	Functional	pAC50	=	4.6	4.6	-91	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	None	52	Human	Functional	pAC50	=	4.6	4.6	-91	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	2202	3132	None	63	Human	Functional	pAC50	=	4.6	4.6	-389	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3132	None	63	Human	Functional	pAC50	=	4.6	4.6	-389	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850.0	3132	None	63	Human	Functional	pAC50	=	4.6	4.6	-389	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3132	None	63	Human	Functional	pAC50	=	4.6	4.6	-389	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3132	None	63	Human	Functional	pAC50	=	4.6	4.6	-389	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3132	None	63	Human	Functional	pAC50	=	4.6	4.6	-389	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	39941	118370	None	43	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	3	1	3	4.3	CC(C(=O)O)c1ccc2oc(-c3ccc(Cl)cc3)nc2c1	10.1038/s41467-023-40064-9
	CHEMBL340978	118370	None	43	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	301	3	1	3	4.3	CC(C(=O)O)c1ccc2oc(-c3ccc(Cl)cc3)nc2c1	10.1038/s41467-023-40064-9
	5280453	208429	None	49	Human	Functional	pAC50	=	4.6	4.6	-5	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	416	6	3	3	5.7	C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL846	208429	None	49	Human	Functional	pAC50	=	4.6	4.6	-5	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	416	6	3	3	5.7	C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O	10.1038/s41467-023-40064-9
	2749	32651	None	61	Human	Functional	pAC50	=	4.6	4.6	1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	207	1	1	3	2.4	Cc1cc(C2CCCCC2)n(O)c(=O)c1	10.1038/s41467-023-40064-9
	CHEMBL1413	32651	None	61	Human	Functional	pAC50	=	4.6	4.6	1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	207	1	1	3	2.4	Cc1cc(C2CCCCC2)n(O)c(=O)c1	10.1038/s41467-023-40064-9
	9846332	52074	None	27	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	444	2	3	5	2.4	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C(Cl)=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO	10.1038/s41467-023-40064-9
	CHEMBL1587228	52074	None	27	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	444	2	3	5	2.4	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C(Cl)=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO	10.1038/s41467-023-40064-9
	3157	1470	None	44	Human	Functional	pAC50	=	6.6	6.6	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	3157.0	1470	None	44	Human	Functional	pAC50	=	6.6	6.6	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	None	44	Human	Functional	pAC50	=	6.6	6.6	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	None	44	Human	Functional	pAC50	=	6.6	6.6	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	None	44	Human	Functional	pAC50	=	6.6	6.6	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	None	44	Human	Functional	pAC50	=	6.6	6.6	-38	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	27901	78236	None	18	Human	Functional	pAC50	=	4.6	4.6	-33	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2105458	78236	None	18	Human	Functional	pAC50	=	4.6	4.6	-33	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	2993	114756	None	14	Human	Functional	pAC50	=	4.6	4.6	-177	13	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL121663	114756	None	14	Human	Functional	pAC50	=	4.6	4.6	-177	13	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL333826	114756	None	14	Human	Functional	pAC50	=	4.6	4.6	-177	13	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	1343	1889	None	43	Human	Functional	pAC50	=	7.6	7.6	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	None	43	Human	Functional	pAC50	=	7.6	7.6	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519.0	1889	None	43	Human	Functional	pAC50	=	7.6	7.6	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	None	43	Human	Functional	pAC50	=	7.6	7.6	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	None	43	Human	Functional	pAC50	=	7.6	7.6	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	None	43	Human	Functional	pAC50	=	7.6	7.6	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	2169	44861	None	29	Human	Functional	pAC50	=	6.6	6.6	-4	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44861	None	29	Human	Functional	pAC50	=	6.6	6.6	-4	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	9853053	120583	None	54	Human	Functional	pAC50	=	5.6	5.6	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL354541	120583	None	54	Human	Functional	pAC50	=	5.6	5.6	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	93154	5438	None	24	Human	Functional	pAC50	=	5.6	5.6	-316	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL107360	5438	None	24	Human	Functional	pAC50	=	5.6	5.6	-316	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
	3735	208689	None	52	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	571	4	2	2	3.7	CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL867	208689	None	52	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	571	4	2	2	3.7	CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O	10.1038/s41467-023-40064-9
	65863	14471	None	40	Human	Functional	pAC50	=	4.6	4.6	-14	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1201196	14471	None	40	Human	Functional	pAC50	=	4.6	4.6	-14	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
	7547	5506	None	61	Human	Functional	pAC50	=	5.6	5.6	-3	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	2	2	1	5.3	O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1076347	5506	None	61	Human	Functional	pAC50	=	5.6	5.6	-3	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	2	2	1	5.3	O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	65646	121365	None	16	Human	Functional	pAC50	=	4.6	4.6	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	6	2	9	0.8	Cc1oc(=O)oc1COC(=O)[C@@H]1N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
	CHEMBL3580454	121365	None	16	Human	Functional	pAC50	=	4.6	4.6	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	461	6	2	9	0.8	Cc1oc(=O)oc1COC(=O)[C@@H]1N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1(C)C	10.1038/s41467-023-40064-9
	71743	78296	None	47	Human	Functional	pAC50	=	4.6	4.6	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	353	3	0	4	3.6	O=C(Oc1ccc2c(c1)CCCN2C(=O)C(Cl)Cl)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2107014	78296	None	47	Human	Functional	pAC50	=	4.6	4.6	-1	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	353	3	0	4	3.6	O=C(Oc1ccc2c(c1)CCCN2C(=O)C(Cl)Cl)c1ccco1	10.1038/s41467-023-40064-9
	5440	28732	None	28	Human	Functional	pAC50	=	4.6	4.6	-1995	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5440.0	28732	None	28	Human	Functional	pAC50	=	4.6	4.6	-1995	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1378	28732	None	28	Human	Functional	pAC50	=	4.6	4.6	-1995	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB00372	28732	None	28	Human	Functional	pAC50	=	4.6	4.6	-1995	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	2705	3842	None	44	Human	Functional	pAC50	=	4.6	4.6	-1288	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	360	3842	None	44	Human	Functional	pAC50	=	4.6	4.6	-1288	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879	3842	None	44	Human	Functional	pAC50	=	4.6	4.6	-1288	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	443879.0	3842	None	44	Human	Functional	pAC50	=	4.6	4.6	-1288	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL1382	3842	None	44	Human	Functional	pAC50	=	4.6	4.6	-1288	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	DB01036	3842	None	44	Human	Functional	pAC50	=	4.6	4.6	-1288	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	7	1	2	5.3	Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O	10.1038/s41467-023-40064-9
	104870	98934	None	37	Human	Functional	pAC50	=	5.6	5.6	-8	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	5374	98934	None	37	Human	Functional	pAC50	=	5.6	5.6	-8	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	CHEMBL279085	98934	None	37	Human	Functional	pAC50	=	5.6	5.6	-8	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	10.1038/s41467-023-40064-9
	21722	17999	None	26	Human	Functional	pAC50	=	4.6	4.6	-16	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17999	None	26	Human	Functional	pAC50	=	4.6	4.6	-16	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	5282219	35878	None	48	Human	Functional	pAC50	=	4.6	4.6	-4	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	450	12	1	5	5.7	CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1441961	35878	None	48	Human	Functional	pAC50	=	4.6	4.6	-4	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	450	12	1	5	5.7	CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1	10.1038/s41467-023-40064-9
	16678941	78182	None	61	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	452	5	2	5	4.7	Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cccc(C(=O)O)c1	10.1038/s41467-023-40064-9
	CHEMBL2103870	78182	None	61	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	452	5	2	5	4.7	Cc1ccc(NC(=O)C2(c3ccc4c(c3)OC(F)(F)O4)CC2)nc1-c1cccc(C(=O)O)c1	10.1038/s41467-023-40064-9
	71927	78434	None	13	Human	Functional	pAC50	=	4.6	4.6	-2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL2106667	78434	None	13	Human	Functional	pAC50	=	4.6	4.6	-2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL2110922	78434	None	13	Human	Functional	pAC50	=	4.6	4.6	-2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	202	2	1	3	0.9	COc1cc(N)cn[n+]1-c1ccccc1	10.1038/s41467-023-40064-9
	1549120	198942	None	55	Human	Functional	pAC50	=	4.6	4.6	-16	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL56337	198942	None	55	Human	Functional	pAC50	=	4.6	4.6	-16	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	319	4	1	4	2.9	CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1	10.1038/s41467-023-40064-9
	24821094	67115	None	58	Human	Functional	pAC50	=	4.6	4.6	-6	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1873475	67115	None	58	Human	Functional	pAC50	=	4.6	4.6	-6	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	440	5	1	7	4.2	C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1	10.1038/s41467-023-40064-9
	446156	39838	None	23	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	459	11	3	5	4.9	COCc1c(C(C)C)nc(C(C)C)c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c1-c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL1477	39838	None	23	Human	Functional	pAC50	=	4.6	4.6	-1	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	459	11	3	5	4.9	COCc1c(C(C)C)nc(C(C)C)c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c1-c1ccc(F)cc1	10.1038/s41467-023-40064-9
	1027	1576	None	51	Human	Functional	pAC50	=	5.6	5.6	-676	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	3241	1576	None	51	Human	Functional	pAC50	=	5.6	5.6	-676	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	3241.0	1576	None	51	Human	Functional	pAC50	=	5.6	5.6	-676	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	7176	1576	None	51	Human	Functional	pAC50	=	5.6	5.6	-676	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL1106	1576	None	51	Human	Functional	pAC50	=	5.6	5.6	-676	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB00751	1576	None	51	Human	Functional	pAC50	=	5.6	5.6	-676	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	37464	19228	None	19	Human	Functional	pAC50	=	5.6	5.6	-707	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
	37464.0	19228	None	19	Human	Functional	pAC50	=	5.6	5.6	-707	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1290	19228	None	19	Human	Functional	pAC50	=	5.6	5.6	-707	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
	DB01359	19228	None	19	Human	Functional	pAC50	=	5.6	5.6	-707	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
	37907	35407	None	55	Human	Functional	pAC50	=	4.6	4.6	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	292	4	0	4	3.7	CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL1437764	35407	None	55	Human	Functional	pAC50	=	4.6	4.6	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	292	4	0	4	3.7	CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n1ccnc1	10.1038/s41467-023-40064-9
	3336	95054	None	22	Human	Functional	pAC50	=	4.6	4.6	-5248	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1405922	95054	None	22	Human	Functional	pAC50	=	4.6	4.6	-5248	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL254832	95054	None	22	Human	Functional	pAC50	=	4.6	4.6	-5248	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	6989	101006	None	67	Human	Functional	pAC50	=	4.6	4.6	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	150	1	1	1	2.8	Cc1ccc(C(C)C)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL29411	101006	None	67	Human	Functional	pAC50	=	4.6	4.6	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	150	1	1	1	2.8	Cc1ccc(C(C)C)c(O)c1	10.1038/s41467-023-40064-9
	60663	175773	None	30	Human	Functional	pAC50	=	4.6	4.6	-8	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1421212	175773	None	30	Human	Functional	pAC50	=	4.6	4.6	-8	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL1534525	175773	None	30	Human	Functional	pAC50	=	4.6	4.6	-8	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	CHEMBL45816	175773	None	30	Human	Functional	pAC50	=	4.6	4.6	-8	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
	3606	205946	None	40	Human	Functional	pAC50	=	4.6	4.6	-3	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL6615	205946	None	40	Human	Functional	pAC50	=	4.6	4.6	-3	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	65948	18563	None	62	Human	Functional	pAC50	=	4.6	4.6	-12	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	CHEMBL1275868	18563	None	62	Human	Functional	pAC50	=	4.6	4.6	-12	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	582	9	2	9	4.7	CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1	10.1038/s41467-023-40064-9
	54679224	59923	None	67	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	145	0	2	3	1.1	Oc1cc(O)c(Cl)cn1	10.1038/s41467-023-40064-9
	CHEMBL1730601	59923	None	67	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	145	0	2	3	1.1	Oc1cc(O)c(Cl)cn1	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Functional	pAC50	=	7.6	7.6	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Functional	pAC50	=	7.6	7.6	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Functional	pAC50	=	7.6	7.6	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Functional	pAC50	=	7.6	7.6	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Functional	pAC50	=	7.6	7.6	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Functional	pAC50	=	7.6	7.6	-63	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2389	3331	None	72	Human	Functional	pAC50	=	7.6	7.6	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	None	72	Human	Functional	pAC50	=	7.6	7.6	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073.0	3331	None	72	Human	Functional	pAC50	=	7.6	7.6	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	None	72	Human	Functional	pAC50	=	7.6	7.6	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	None	72	Human	Functional	pAC50	=	7.6	7.6	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	None	72	Human	Functional	pAC50	=	7.6	7.6	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2337	3256	None	51	Human	Functional	pAC50	=	6.6	6.6	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	None	51	Human	Functional	pAC50	=	6.6	6.6	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	None	51	Human	Functional	pAC50	=	6.6	6.6	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002.0	3256	None	51	Human	Functional	pAC50	=	6.6	6.6	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	None	51	Human	Functional	pAC50	=	6.6	6.6	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	None	51	Human	Functional	pAC50	=	6.6	6.6	-4	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	135	2532	None	33	Human	Functional	pAC50	=	5.6	5.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	None	33	Human	Functional	pAC50	=	5.6	5.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	None	33	Human	Functional	pAC50	=	5.6	5.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184.0	2532	None	33	Human	Functional	pAC50	=	5.6	5.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	None	33	Human	Functional	pAC50	=	5.6	5.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	None	33	Human	Functional	pAC50	=	5.6	5.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	2333	142422	None	66	Human	Functional	pAC50	=	5.6	5.6	-2	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142422	None	66	Human	Functional	pAC50	=	5.6	5.6	-2	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	135	2532	None	33	Human	Functional	pAC50	=	6.6	6.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	None	33	Human	Functional	pAC50	=	6.6	6.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	None	33	Human	Functional	pAC50	=	6.6	6.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184.0	2532	None	33	Human	Functional	pAC50	=	6.6	6.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	None	33	Human	Functional	pAC50	=	6.6	6.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	None	33	Human	Functional	pAC50	=	6.6	6.6	-72	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	135400189	44589	None	42	Human	Functional	pAC50	=	4.6	4.6	-26	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	CHEMBL1520	44589	None	42	Human	Functional	pAC50	=	4.6	4.6	-26	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	488	8	1	8	2.1	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12	10.1038/s41467-023-40064-9
	1155	1629	None	38	Human	Functional	pAC50	=	4.6	4.6	-363	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	3343	1629	None	38	Human	Functional	pAC50	=	4.6	4.6	-363	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	557	1629	None	38	Human	Functional	pAC50	=	4.6	4.6	-363	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL32800	1629	None	38	Human	Functional	pAC50	=	4.6	4.6	-363	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	DB01288	1629	None	38	Human	Functional	pAC50	=	4.6	4.6	-363	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	6	5	5	2.1	CC(Cc1ccc(cc1)O)NCC(c1cc(O)cc(c1)O)O	10.1038/s41467-023-40064-9
	65981	18461	None	59	Human	Functional	pAC50	=	4.6	4.6	-2	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	452	10	2	4	5.2	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1272	18461	None	59	Human	Functional	pAC50	=	4.6	4.6	-2	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	452	10	2	4	5.2	CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N2CCCCC2)ccc1C(=O)O	10.1038/s41467-023-40064-9
	6010	30706	None	19	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	CHEMBL1395	30706	None	19	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	5328940	100270	None	65	Human	Functional	pAC50	=	5.6	5.6	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	CHEMBL288441	100270	None	65	Human	Functional	pAC50	=	5.6	5.6	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
	1960	2857	None	46	Human	Functional	pAC50	=	6.6	6.6	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	2857	None	46	Human	Functional	pAC50	=	6.6	6.6	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260.0	2857	None	46	Human	Functional	pAC50	=	6.6	6.6	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	2857	None	46	Human	Functional	pAC50	=	6.6	6.6	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	2857	None	46	Human	Functional	pAC50	=	6.6	6.6	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	2857	None	46	Human	Functional	pAC50	=	6.6	6.6	-2	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	2448	99377	None	50	Human	Functional	pAC50	=	6.6	6.6	-12	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	2448.0	99377	None	50	Human	Functional	pAC50	=	6.6	6.6	-12	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99377	None	50	Human	Functional	pAC50	=	6.6	6.6	-12	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	DB12401	99377	None	50	Human	Functional	pAC50	=	6.6	6.6	-12	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	3151	1462	None	65	Human	Functional	pAC50	=	5.6	5.6	-223	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3151.0	1462	None	65	Human	Functional	pAC50	=	5.6	5.6	-223	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	None	65	Human	Functional	pAC50	=	5.6	5.6	-223	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	None	65	Human	Functional	pAC50	=	5.6	5.6	-223	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	None	65	Human	Functional	pAC50	=	5.6	5.6	-223	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	None	65	Human	Functional	pAC50	=	5.6	5.6	-223	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	6256	9673	None	53	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	2	3	6	-0.8	O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL1129	9673	None	53	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	2	3	6	-0.8	O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1C(F)(F)F	10.1038/s41467-023-40064-9
	4006	59126	None	56	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	288	4	0	6	3.1	CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1	10.1038/s41467-023-40064-9
	CHEMBL1697754	59126	None	56	Human	Functional	pAC50	=	4.6	4.6	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	288	4	0	6	3.1	CC(C)OC(=O)C(C(=O)OC(C)C)=C1SC=CS1	10.1038/s41467-023-40064-9
	14052	172681	None	32	Human	Functional	pAC50	=	4.6	4.6	-5495	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	204	9	4	4	-0.3	CC[C@@H](CO)NCCN[C@@H](CC)CO	10.1038/s41467-023-40064-9
	CHEMBL44884	172681	None	32	Human	Functional	pAC50	=	4.6	4.6	-5495	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	204	9	4	4	-0.3	CC[C@@H](CO)NCCN[C@@H](CC)CO	10.1038/s41467-023-40064-9
	1046	205109	None	68	Human	Functional	pAC50	=	4.6	4.6	-1412	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	123	1	1	3	-0.4	NC(=O)c1cnccn1	10.1038/s41467-023-40064-9
	CHEMBL614	205109	None	68	Human	Functional	pAC50	=	4.6	4.6	-1412	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	123	1	1	3	-0.4	NC(=O)c1cnccn1	10.1038/s41467-023-40064-9
	43082	60303	None	26	Human	Functional	pAC50	=	4.6	4.6	-72	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1742452	60303	None	26	Human	Functional	pAC50	=	4.6	4.6	-72	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	219024	3300	None	47	Human	Functional	pAC50	=	4.6	4.6	-6456	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1038/s41467-023-40064-9
	219024.0	3300	None	47	Human	Functional	pAC50	=	4.6	4.6	-6456	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1038/s41467-023-40064-9
	2362	3300	None	47	Human	Functional	pAC50	=	4.6	4.6	-6456	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1038/s41467-023-40064-9
	5596	3300	None	47	Human	Functional	pAC50	=	4.6	4.6	-6456	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1038/s41467-023-40064-9
	CHEMBL317052	3300	None	47	Human	Functional	pAC50	=	4.6	4.6	-6456	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1038/s41467-023-40064-9
	DB06213	3300	None	47	Human	Functional	pAC50	=	4.6	4.6	-6456	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	390	4	5	12	-2.4	OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC	10.1038/s41467-023-40064-9
	2520	206466	None	47	Human	Functional	pAC50	=	4.6	4.6	-50	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	206466	None	47	Human	Functional	pAC50	=	4.6	4.6	-50	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	206466	None	47	Human	Functional	pAC50	=	4.6	4.6	-50	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	11154555	800	None	50	Human	Functional	pAC50	=	5.5	5.5	-1148	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	11154555.0	800	None	50	Human	Functional	pAC50	=	5.5	5.5	-1148	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	5037	800	None	50	Human	Functional	pAC50	=	5.5	5.5	-1148	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	7671	800	None	50	Human	Functional	pAC50	=	5.5	5.5	-1148	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL2028019	800	None	50	Human	Functional	pAC50	=	5.5	5.5	-1148	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL3085826	800	None	50	Human	Functional	pAC50	=	5.5	5.5	-1148	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB06016	800	None	50	Human	Functional	pAC50	=	5.5	5.5	-1148	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	2406	100458	None	56	Human	Functional	pAC50	=	5.5	5.5	-16	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
	CHEMBL290106	100458	None	56	Human	Functional	pAC50	=	5.5	5.5	-16	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
	3627	44143	None	12	Human	Functional	pAC50	=	5.5	5.5	-39	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1515447	44143	None	12	Human	Functional	pAC50	=	5.5	5.5	-39	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Functional	pAC50	=	7.5	7.5	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Functional	pAC50	=	7.5	7.5	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Functional	pAC50	=	7.5	7.5	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Functional	pAC50	=	7.5	7.5	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Functional	pAC50	=	7.5	7.5	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2749	344	None	32	Human	Functional	pAC50	=	7.5	7.5	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	5574	344	None	32	Human	Functional	pAC50	=	7.5	7.5	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	5574.0	344	None	32	Human	Functional	pAC50	=	7.5	7.5	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7237	344	None	32	Human	Functional	pAC50	=	7.5	7.5	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL829	344	None	32	Human	Functional	pAC50	=	7.5	7.5	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01246	344	None	32	Human	Functional	pAC50	=	7.5	7.5	-1	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2142	3096	None	36	Human	Functional	pAC50	=	6.5	6.5	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3096	None	36	Human	Functional	pAC50	=	6.5	6.5	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3096	None	36	Human	Functional	pAC50	=	6.5	6.5	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3096	None	36	Human	Functional	pAC50	=	6.5	6.5	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775.0	3096	None	36	Human	Functional	pAC50	=	6.5	6.5	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3096	None	36	Human	Functional	pAC50	=	6.5	6.5	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3096	None	36	Human	Functional	pAC50	=	6.5	6.5	-1	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	6337614	13001	None	38	Human	Functional	pAC50	=	4.5	4.5	-26	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL1189679	13001	None	38	Human	Functional	pAC50	=	4.5	4.5	-26	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	296	1	0	2	2.7	O=C1c2cccc3c2[C@H](CCC3)CN1[C@@H]1CN2CCC1CC2	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-120	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	9051	14447	None	46	Human	Functional	pAC50	=	4.5	4.5	-5	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	1	0	2	4.5	CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL1200853	14447	None	46	Human	Functional	pAC50	=	4.5	4.5	-5	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	1	0	2	4.5	CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	4121	50850	None	43	Human	Functional	pAC50	=	4.5	4.5	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	359	2	2	5	0.6	CN1C(CCl)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O	10.1038/s41467-023-40064-9
	CHEMBL1577	50850	None	43	Human	Functional	pAC50	=	4.5	4.5	-1	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	359	2	2	5	0.6	CN1C(CCl)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O	10.1038/s41467-023-40064-9
	24765256	173401	None	21	Human	Functional	pAC50	=	4.5	4.5	-2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	757	6	3	9	3.9	CC[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1	10.1038/s41467-023-40064-9
	CHEMBL4525964	173401	None	21	Human	Functional	pAC50	=	4.5	4.5	-2	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	757	6	3	9	3.9	CC[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@H](C(C)(C)C)NC(=O)OCC(C)(C)CCCCc1cccc3c1CN(C3)C(=O)O2)C(=O)NS(=O)(=O)C1CC1	10.1038/s41467-023-40064-9
	15387	45836	None	41	Human	Functional	pAC50	=	6.5	6.5	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1531134	45836	None	41	Human	Functional	pAC50	=	6.5	6.5	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	5748845	78260	None	10	Human	Functional	pAC50	=	4.5	4.5	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	522	9	4	13	-3.2	CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccc(N)n3CCO)CS[C@H]12)c1csc(N)n1	10.1038/s41467-023-40064-9
	CHEMBL2105940	78260	None	10	Human	Functional	pAC50	=	4.5	4.5	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	522	9	4	13	-3.2	CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3ccc(N)n3CCO)CS[C@H]12)c1csc(N)n1	10.1038/s41467-023-40064-9
	68818	78297	None	21	Human	Functional	pAC50	=	8.5	8.5	3	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	217	1	2	3	2.2	c1ccc2c(SC3=NCCN3)c[nH]c2c1	10.1038/s41467-023-40064-9
	CHEMBL2107015	78297	None	21	Human	Functional	pAC50	=	8.5	8.5	3	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	217	1	2	3	2.2	c1ccc2c(SC3=NCCN3)c[nH]c2c1	10.1038/s41467-023-40064-9
	3294	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360.0	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	None	61	Human	Functional	pAC50	=	8.5	8.5	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	115368	3056	None	34	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	2112	3056	None	34	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	7556	3056	None	34	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1472975	3056	None	34	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	DB08922	3056	None	34	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
	4151	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	493	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	5312125.0	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL24778	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	DB06207	3607	None	59	Human	Functional	pAC50	=	8.5	8.5	1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
	6077	150786	None	16	Human	Functional	pAC50	=	8.5	8.5	3	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	150786	None	16	Human	Functional	pAC50	=	8.5	8.5	3	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	2107	3055	None	44	Human	Functional	pAC50	=	8.5	8.5	2	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	4747	3055	None	44	Human	Functional	pAC50	=	8.5	8.5	2	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	4747.0	3055	None	44	Human	Functional	pAC50	=	8.5	8.5	2	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	9216	3055	None	44	Human	Functional	pAC50	=	8.5	8.5	2	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL251940	3055	None	44	Human	Functional	pAC50	=	8.5	8.5	2	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB01608	3055	None	44	Human	Functional	pAC50	=	8.5	8.5	2	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	62867	3129	None	27	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	7557	3129	None	27	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL398880	3129	None	27	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01621	3129	None	27	Human	Functional	pAC50	=	8.5	8.5	-1	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2407	3372	None	50	Human	Functional	pAC50	=	8.5	8.5	1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	None	50	Human	Functional	pAC50	=	8.5	8.5	1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227.0	3372	None	50	Human	Functional	pAC50	=	8.5	8.5	1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	None	50	Human	Functional	pAC50	=	8.5	8.5	1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	None	50	Human	Functional	pAC50	=	8.5	8.5	1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	None	50	Human	Functional	pAC50	=	8.5	8.5	1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	5568	199956	None	21	Human	Functional	pAC50	=	8.5	8.5	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	5568.0	199956	None	21	Human	Functional	pAC50	=	8.5	8.5	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	66069	199956	None	21	Human	Functional	pAC50	=	8.5	8.5	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL1201102	199956	None	21	Human	Functional	pAC50	=	8.5	8.5	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	CHEMBL570	199956	None	21	Human	Functional	pAC50	=	8.5	8.5	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	DB00508	199956	None	21	Human	Functional	pAC50	=	8.5	8.5	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
	11976	920	None	44	Human	Functional	pAC50	=	8.5	8.5	-1	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467	920	None	44	Human	Functional	pAC50	=	8.5	8.5	-1	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	667467.0	920	None	44	Human	Functional	pAC50	=	8.5	8.5	-1	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	CHEMBL908	920	None	44	Human	Functional	pAC50	=	8.5	8.5	-1	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	DB01239	920	None	44	Human	Functional	pAC50	=	8.5	8.5	-1	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
	2585	803	None	59	Human	Functional	pAC50	=	6.5	6.5	-50	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2585.0	803	None	59	Human	Functional	pAC50	=	6.5	6.5	-50	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	None	59	Human	Functional	pAC50	=	6.5	6.5	-50	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	None	59	Human	Functional	pAC50	=	6.5	6.5	-50	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	None	59	Human	Functional	pAC50	=	6.5	6.5	-50	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	None	59	Human	Functional	pAC50	=	6.5	6.5	-50	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	1524	2181	None	61	Human	Functional	pAC50	=	6.5	6.5	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	197	2181	None	61	Human	Functional	pAC50	=	6.5	6.5	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3822	2181	None	61	Human	Functional	pAC50	=	6.5	6.5	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3822.0	2181	None	61	Human	Functional	pAC50	=	6.5	6.5	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	88	2181	None	61	Human	Functional	pAC50	=	6.5	6.5	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL51	2181	None	61	Human	Functional	pAC50	=	6.5	6.5	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB12465	2181	None	61	Human	Functional	pAC50	=	6.5	6.5	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2583	3776	None	69	Human	Functional	pAC50	=	5.5	5.5	-3019	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	None	69	Human	Functional	pAC50	=	5.5	5.5	-3019	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	None	69	Human	Functional	pAC50	=	5.5	5.5	-3019	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999.0	3776	None	69	Human	Functional	pAC50	=	5.5	5.5	-3019	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	None	69	Human	Functional	pAC50	=	5.5	5.5	-3019	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	None	69	Human	Functional	pAC50	=	5.5	5.5	-3019	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	3601	14509	None	4	Human	Functional	pAC50	=	5.5	5.5	-45	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1201349	14509	None	4	Human	Functional	pAC50	=	5.5	5.5	-45	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
	212	3806	None	35	Human	Functional	pAC50	=	6.5	6.5	-28	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	None	35	Human	Functional	pAC50	=	6.5	6.5	-28	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	None	35	Human	Functional	pAC50	=	6.5	6.5	-28	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651.0	3806	None	35	Human	Functional	pAC50	=	6.5	6.5	-28	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	None	35	Human	Functional	pAC50	=	6.5	6.5	-28	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	None	35	Human	Functional	pAC50	=	6.5	6.5	-28	22	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	1043	1582	None	6	Human	Functional	pAC50	=	5.5	5.5	-15488	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	1582	None	6	Human	Functional	pAC50	=	5.5	5.5	-15488	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	1582	None	6	Human	Functional	pAC50	=	5.5	5.5	-15488	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223.0	1582	None	6	Human	Functional	pAC50	=	5.5	5.5	-15488	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	1582	None	6	Human	Functional	pAC50	=	5.5	5.5	-15488	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	1582	None	6	Human	Functional	pAC50	=	5.5	5.5	-15488	22	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	118422671	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562.0	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301.0	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194.0	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL2365658	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL3526436	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	None	41	Human	Functional	pAC50	=	5.5	5.5	-1023	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	4452	2762	None	13	Human	Functional	pAC50	=	5.5	5.5	-10232	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	None	13	Human	Functional	pAC50	=	5.5	5.5	-10232	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	None	13	Human	Functional	pAC50	=	5.5	5.5	-10232	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	1720	2957	None	23	Human	Functional	pAC50	=	5.5	5.5	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	4	4	1.1	OC(c1cc(O)cc(c1)O)CNC(C)C	10.1038/s41467-023-40064-9
	4086	2957	None	23	Human	Functional	pAC50	=	5.5	5.5	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	4	4	1.1	OC(c1cc(O)cc(c1)O)CNC(C)C	10.1038/s41467-023-40064-9
	7250	2957	None	23	Human	Functional	pAC50	=	5.5	5.5	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	4	4	1.1	OC(c1cc(O)cc(c1)O)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL776	2957	None	23	Human	Functional	pAC50	=	5.5	5.5	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	4	4	1.1	OC(c1cc(O)cc(c1)O)CNC(C)C	10.1038/s41467-023-40064-9
	DB00816	2957	None	23	Human	Functional	pAC50	=	5.5	5.5	-	1	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	211	4	4	4	1.1	OC(c1cc(O)cc(c1)O)CNC(C)C	10.1038/s41467-023-40064-9
	2389	3331	None	72	Human	Functional	pAC50	=	7.5	7.5	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	None	72	Human	Functional	pAC50	=	7.5	7.5	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073.0	3331	None	72	Human	Functional	pAC50	=	7.5	7.5	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	None	72	Human	Functional	pAC50	=	7.5	7.5	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	None	72	Human	Functional	pAC50	=	7.5	7.5	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	None	72	Human	Functional	pAC50	=	7.5	7.5	-13	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	228	445	None	20	Human	Functional	pAC50	=	6.5	6.5	-75	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	None	20	Human	Functional	pAC50	=	6.5	6.5	-75	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	None	20	Human	Functional	pAC50	=	6.5	6.5	-75	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005.0	445	None	20	Human	Functional	pAC50	=	6.5	6.5	-75	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	None	20	Human	Functional	pAC50	=	6.5	6.5	-75	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	None	20	Human	Functional	pAC50	=	6.5	6.5	-75	20	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	2169	44861	None	29	Human	Functional	pAC50	=	6.5	6.5	-4	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44861	None	29	Human	Functional	pAC50	=	6.5	6.5	-4	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	3584	3777	None	45	Human	Functional	pAC50	=	6.5	6.5	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	5401	3777	None	45	Human	Functional	pAC50	=	6.5	6.5	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	5401.0	3777	None	45	Human	Functional	pAC50	=	6.5	6.5	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	7302	3777	None	45	Human	Functional	pAC50	=	6.5	6.5	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL611	3777	None	45	Human	Functional	pAC50	=	6.5	6.5	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	DB01162	3777	None	45	Human	Functional	pAC50	=	6.5	6.5	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	5482	14425	None	55	Human	Functional	pAC50	=	5.5	5.5	-3	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1200438	14425	None	55	Human	Functional	pAC50	=	5.5	5.5	-3	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	6	0	4	5.9	Clc1ccc(C(Cn2ccnc2)OCc2ccsc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2993	114756	None	14	Human	Functional	pAC50	=	5.5	5.5	-177	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL121663	114756	None	14	Human	Functional	pAC50	=	5.5	5.5	-177	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL333826	114756	None	14	Human	Functional	pAC50	=	5.5	5.5	-177	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
	681	1465	None	47	Human	Functional	pAC50	=	6.5	6.5	-162	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	681.0	1465	None	47	Human	Functional	pAC50	=	6.5	6.5	-162	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	940	1465	None	47	Human	Functional	pAC50	=	6.5	6.5	-162	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	947	1465	None	47	Human	Functional	pAC50	=	6.5	6.5	-162	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL59	1465	None	47	Human	Functional	pAC50	=	6.5	6.5	-162	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00988	1465	None	47	Human	Functional	pAC50	=	6.5	6.5	-162	15	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	2105	3054	None	28	Human	Functional	pAC50	=	6.5	6.5	-158	25	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	None	28	Human	Functional	pAC50	=	6.5	6.5	-158	25	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	None	28	Human	Functional	pAC50	=	6.5	6.5	-158	25	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	None	28	Human	Functional	pAC50	=	6.5	6.5	-158	25	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	None	28	Human	Functional	pAC50	=	6.5	6.5	-158	25	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	2220	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-269	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-269	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400.0	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-269	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-269	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-269	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	None	58	Human	Functional	pAC50	=	5.5	5.5	-269	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	1086	1590	None	21	Human	Functional	pAC50	=	5.5	5.5	-91	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	3290	1590	None	21	Human	Functional	pAC50	=	5.5	5.5	-91	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	3290.0	1590	None	21	Human	Functional	pAC50	=	5.5	5.5	-91	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	7181	1590	None	21	Human	Functional	pAC50	=	5.5	5.5	-91	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	CHEMBL1206	1590	None	21	Human	Functional	pAC50	=	5.5	5.5	-91	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	DB00392	1590	None	21	Human	Functional	pAC50	=	5.5	5.5	-91	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
	2200	20210	None	38	Human	Functional	pAC50	=	6.5	6.5	1	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2200.0	20210	None	38	Human	Functional	pAC50	=	6.5	6.5	1	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1256819	20210	None	38	Human	Functional	pAC50	=	6.5	6.5	1	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1305	20210	None	38	Human	Functional	pAC50	=	6.5	6.5	1	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	DB08799	20210	None	38	Human	Functional	pAC50	=	6.5	6.5	1	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	265	5	1	3	2.7	c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
	2136	3095	None	24	Human	Functional	pAC50	=	6.5	6.5	1	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	None	24	Human	Functional	pAC50	=	6.5	6.5	1	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768.0	3095	None	24	Human	Functional	pAC50	=	6.5	6.5	1	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	None	24	Human	Functional	pAC50	=	6.5	6.5	1	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	None	24	Human	Functional	pAC50	=	6.5	6.5	1	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	None	24	Human	Functional	pAC50	=	6.5	6.5	1	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	68712	100392	None	40	Human	Functional	pAC50	=	5.5	5.5	-4	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	CHEMBL289480	100392	None	40	Human	Functional	pAC50	=	5.5	5.5	-4	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	180	3	1	3	1.2	C1COC(NC(C2CC2)C2CC2)=N1	10.1038/s41467-023-40064-9
	65700	78289	None	22	Human	Functional	pAC50	=	5.5	5.5	-10	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78289	None	22	Human	Functional	pAC50	=	5.5	5.5	-10	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	4066	207084	None	54	Human	Functional	pAC50	=	6.5	6.5	-21	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4066.0	207084	None	54	Human	Functional	pAC50	=	6.5	6.5	-21	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	207084	None	54	Human	Functional	pAC50	=	6.5	6.5	-21	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	DB01071	207084	None	54	Human	Functional	pAC50	=	6.5	6.5	-21	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	3108	209745	None	64	Human	Functional	pAC50	=	5.5	5.5	-1	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	209745	None	64	Human	Functional	pAC50	=	5.5	5.5	-1	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	47936	193531	None	56	Human	Functional	pAC50	=	5.5	5.5	-74	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	CHEMBL52606	193531	None	56	Human	Functional	pAC50	=	5.5	5.5	-74	6	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	410	2	3	7	1.5	C=C[C@@]1(C)CC(=O)[C@@]2(O)[C@](C)(O1)[C@@H](OC(C)=O)[C@@H](O)[C@H]1C(C)(C)CC[C@H](O)[C@@]12C	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Functional	pAC50	=	6.4	6.4	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Functional	pAC50	=	6.4	6.4	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Functional	pAC50	=	6.4	6.4	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Functional	pAC50	=	6.4	6.4	-125	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	1971	2866	None	32	Human	Functional	pAC50	=	7.4	7.4	-89	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	None	32	Human	Functional	pAC50	=	7.4	7.4	-89	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	None	32	Human	Functional	pAC50	=	7.4	7.4	-89	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543.0	2866	None	32	Human	Functional	pAC50	=	7.4	7.4	-89	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	None	32	Human	Functional	pAC50	=	7.4	7.4	-89	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	None	32	Human	Functional	pAC50	=	7.4	7.4	-89	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	3584	3777	None	45	Human	Functional	pAC50	=	6.4	6.4	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	5401	3777	None	45	Human	Functional	pAC50	=	6.4	6.4	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	5401.0	3777	None	45	Human	Functional	pAC50	=	6.4	6.4	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	7302	3777	None	45	Human	Functional	pAC50	=	6.4	6.4	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	CHEMBL611	3777	None	45	Human	Functional	pAC50	=	6.4	6.4	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	DB01162	3777	None	45	Human	Functional	pAC50	=	6.4	6.4	-69	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
	124087	1389	None	72	Human	Functional	pAC50	=	5.4	5.4	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	124087.0	1389	None	72	Human	Functional	pAC50	=	5.4	5.4	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	None	72	Human	Functional	pAC50	=	5.4	5.4	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	None	72	Human	Functional	pAC50	=	5.4	5.4	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	None	72	Human	Functional	pAC50	=	5.4	5.4	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	None	72	Human	Functional	pAC50	=	5.4	5.4	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	441074	19421	None	48	Human	Functional	pAC50	=	5.4	5.4	-1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19421	None	48	Human	Functional	pAC50	=	5.4	5.4	-1	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	115	343	None	50	Human	Functional	pAC50	=	7.4	7.4	14	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	2092	343	None	50	Human	Functional	pAC50	=	7.4	7.4	14	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	2092.0	343	None	50	Human	Functional	pAC50	=	7.4	7.4	14	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	7109	343	None	50	Human	Functional	pAC50	=	7.4	7.4	14	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	CHEMBL709	343	None	50	Human	Functional	pAC50	=	7.4	7.4	14	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	DB00346	343	None	50	Human	Functional	pAC50	=	7.4	7.4	14	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	389	8	3	7	2.0	COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C	10.1038/s41467-023-40064-9
	4260	52574	None	20	Human	Functional	pAC50	=	5.4	5.4	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	4260.0	52574	None	20	Human	Functional	pAC50	=	5.4	5.4	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	CHEMBL159226	52574	None	20	Human	Functional	pAC50	=	5.4	5.4	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	DB09205	52574	None	20	Human	Functional	pAC50	=	5.4	5.4	-3	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	279	6	0	4	3.0	CC(=O)Oc1cc(C(C)C)c(OCCN(C)C)cc1C	10.1038/s41467-023-40064-9
	1353	1911	None	63	Human	Functional	pAC50	=	7.4	7.4	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	None	63	Human	Functional	pAC50	=	7.4	7.4	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559.0	1911	None	63	Human	Functional	pAC50	=	7.4	7.4	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	None	63	Human	Functional	pAC50	=	7.4	7.4	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	None	63	Human	Functional	pAC50	=	7.4	7.4	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	None	63	Human	Functional	pAC50	=	7.4	7.4	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	5022	1651	None	58	Human	Functional	pAC50	=	6.4	6.4	-8	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	6918248	1651	None	58	Human	Functional	pAC50	=	6.4	6.4	-8	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	6918248.0	1651	None	58	Human	Functional	pAC50	=	6.4	6.4	-8	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	8182	1651	None	58	Human	Functional	pAC50	=	6.4	6.4	-8	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL231068	1651	None	58	Human	Functional	pAC50	=	6.4	6.4	-8	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	DB04908	1651	None	58	Human	Functional	pAC50	=	6.4	6.4	-8	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
	6075	150196	None	34	Human	Functional	pAC50	=	6.4	6.4	-14	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL395110	150196	None	34	Human	Functional	pAC50	=	6.4	6.4	-14	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	5591	157623	None	57	Human	Functional	pAC50	=	5.4	5.4	-4	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157623	None	57	Human	Functional	pAC50	=	5.4	5.4	-4	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	2181	3128	None	36	Human	Functional	pAC50	=	6.4	6.4	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	4830	3128	None	36	Human	Functional	pAC50	=	6.4	6.4	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	4830.0	3128	None	36	Human	Functional	pAC50	=	6.4	6.4	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	92	3128	None	36	Human	Functional	pAC50	=	6.4	6.4	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	CHEMBL440294	3128	None	36	Human	Functional	pAC50	=	6.4	6.4	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	DB09286	3128	None	36	Human	Functional	pAC50	=	6.4	6.4	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
	2146	3100	None	45	Human	Functional	pAC50	=	8.4	8.4	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	3100	None	45	Human	Functional	pAC50	=	8.4	8.4	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	3100	None	45	Human	Functional	pAC50	=	8.4	8.4	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041.0	3100	None	45	Human	Functional	pAC50	=	8.4	8.4	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	3100	None	45	Human	Functional	pAC50	=	8.4	8.4	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	3100	None	45	Human	Functional	pAC50	=	8.4	8.4	-20	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	17676	7074	None	25	Human	Functional	pAC50	=	8.4	8.4	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	17676.0	7074	None	25	Human	Functional	pAC50	=	8.4	8.4	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7074	None	25	Human	Functional	pAC50	=	8.4	8.4	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7074	None	25	Human	Functional	pAC50	=	8.4	8.4	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB01063	7074	None	25	Human	Functional	pAC50	=	8.4	8.4	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	1427	2013	None	42	Human	Functional	pAC50	=	6.4	6.4	-112	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2013	None	42	Human	Functional	pAC50	=	6.4	6.4	-112	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2013	None	42	Human	Functional	pAC50	=	6.4	6.4	-112	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2013	None	42	Human	Functional	pAC50	=	6.4	6.4	-112	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2013	None	42	Human	Functional	pAC50	=	6.4	6.4	-112	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1385580	29284	None	49	Human	Functional	pAC50	=	5.4	5.4	-478	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615	29284	None	49	Human	Functional	pAC50	=	5.4	5.4	-478	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	4615.0	29284	None	49	Human	Functional	pAC50	=	5.4	5.4	-478	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL13828	29284	None	49	Human	Functional	pAC50	=	5.4	5.4	-478	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB12877	29284	None	49	Human	Functional	pAC50	=	5.4	5.4	-478	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	3952	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5353646	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5353646.0	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5443	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5702063	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	5702063.0	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	CHEMBL1331786	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	CHEMBL420	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	DB00629	1888	None	32	Human	Functional	pAC50	=	7.4	7.4	-4	21	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
	4209	3163	None	48	Human	Functional	pAC50	=	7.4	7.4	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	None	48	Human	Functional	pAC50	=	7.4	7.4	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893.0	3163	None	48	Human	Functional	pAC50	=	7.4	7.4	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	None	48	Human	Functional	pAC50	=	7.4	7.4	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	None	48	Human	Functional	pAC50	=	7.4	7.4	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	None	48	Human	Functional	pAC50	=	7.4	7.4	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	None	48	Human	Functional	pAC50	=	7.4	7.4	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5329102	194838	None	50	Human	Functional	pAC50	=	6.4	6.4	-3	37	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194838	None	50	Human	Functional	pAC50	=	6.4	6.4	-3	37	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	5803	162321	None	58	Human	Functional	pAC50	=	5.4	5.4	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162321	None	58	Human	Functional	pAC50	=	5.4	5.4	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	71897	78277	None	10	Human	Functional	pAC50	=	6.4	6.4	-141	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
	CHEMBL2106537	78277	None	10	Human	Functional	pAC50	=	6.4	6.4	-141	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
	44591583	184642	None	65	Human	Functional	pAC50	=	5.4	5.4	3	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	251	2	1	4	1.6	N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1	10.1038/s41467-023-40064-9
	CHEMBL484785	184642	None	65	Human	Functional	pAC50	=	5.4	5.4	3	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	251	2	1	4	1.6	N#Cc1ccc(Oc2ccc3c(c2)COB3O)cc1	10.1038/s41467-023-40064-9
	5453	206077	None	58	Human	Functional	pAC50	=	7.4	7.4	1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	206077	None	58	Human	Functional	pAC50	=	7.4	7.4	1	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	1613	2348	None	42	Human	Functional	pAC50	=	6.4	6.4	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	None	42	Human	Functional	pAC50	=	6.4	6.4	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	None	42	Human	Functional	pAC50	=	6.4	6.4	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964.0	2348	None	42	Human	Functional	pAC50	=	6.4	6.4	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	None	42	Human	Functional	pAC50	=	6.4	6.4	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	None	42	Human	Functional	pAC50	=	6.4	6.4	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3947	208853	None	39	Human	Functional	pAC50	=	5.4	5.4	-6	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL87708	208853	None	39	Human	Functional	pAC50	=	5.4	5.4	-6	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	3152	188518	None	61	Human	Functional	pAC50	=	5.4	5.4	-9	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188518	None	61	Human	Functional	pAC50	=	5.4	5.4	-9	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	55645	84404	None	3	Human	Functional	pAC50	=	6.4	6.4	-1258	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	55645.0	84404	None	3	Human	Functional	pAC50	=	6.4	6.4	-1258	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84404	None	3	Human	Functional	pAC50	=	6.4	6.4	-1258	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	3689	102826	None	36	Human	Functional	pAC50	=	6.4	6.4	-64	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102826	None	36	Human	Functional	pAC50	=	6.4	6.4	-64	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102826	None	36	Human	Functional	pAC50	=	6.4	6.4	-64	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2324	77126	None	16	Human	Functional	pAC50	=	5.4	5.4	-2	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL2074972	77126	None	16	Human	Functional	pAC50	=	5.4	5.4	-2	11	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	505	7	1	8	4.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC2CCCN(Cc3ccccc3)C2)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	4418	34231	None	58	Human	Functional	pAC50	=	6.3	6.3	-4	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	4418.0	34231	None	58	Human	Functional	pAC50	=	6.3	6.3	-4	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34231	None	58	Human	Functional	pAC50	=	6.3	6.3	-4	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	DB12092	34231	None	58	Human	Functional	pAC50	=	6.3	6.3	-4	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Functional	pAC50	=	6.3	6.3	-8	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Functional	pAC50	=	6.3	6.3	-8	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Functional	pAC50	=	6.3	6.3	-8	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Functional	pAC50	=	6.3	6.3	-8	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Functional	pAC50	=	6.3	6.3	-8	38	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Functional	pAC50	=	5.3	5.3	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Functional	pAC50	=	5.3	5.3	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Functional	pAC50	=	5.3	5.3	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Functional	pAC50	=	5.3	5.3	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	2895	206050	None	27	Human	Functional	pAC50	=	6.3	6.3	-16	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2895.0	206050	None	27	Human	Functional	pAC50	=	6.3	6.3	-16	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	206050	None	27	Human	Functional	pAC50	=	6.3	6.3	-16	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	206050	None	27	Human	Functional	pAC50	=	6.3	6.3	-16	15	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	54682461	84720	None	41	Human	Functional	pAC50	=	5.3	5.3	1	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84720	None	41	Human	Functional	pAC50	=	5.3	5.3	1	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	82153	43915	None	34	Human	Functional	pAC50	=	7.3	7.3	11	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	CHEMBL1512	43915	None	34	Human	Functional	pAC50	=	7.3	7.3	11	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	434	2	2	6	2.3	CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1	10.1038/s41467-023-40064-9
	4011	82440	None	34	Human	Functional	pAC50	=	6.3	6.3	-8	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82440	None	34	Human	Functional	pAC50	=	6.3	6.3	-8	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2710	84342	None	29	Human	Functional	pAC50	=	5.3	5.3	-10	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	2710.0	84342	None	29	Human	Functional	pAC50	=	5.3	5.3	-10	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1889091	84342	None	29	Human	Functional	pAC50	=	5.3	5.3	-10	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL22150	84342	None	29	Human	Functional	pAC50	=	5.3	5.3	-10	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	DB08936	84342	None	29	Human	Functional	pAC50	=	5.3	5.3	-10	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
	54758501	139154	None	52	Human	Functional	pAC50	=	5.3	5.3	-1621	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	CHEMBL3786343	139154	None	52	Human	Functional	pAC50	=	5.3	5.3	-1621	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
	6719	32676	None	23	Human	Functional	pAC50	=	5.3	5.3	-6	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	340	4	0	3	4.1	O=C1c2ccccc2C(=O)C1C(=O)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1413199	32676	None	23	Human	Functional	pAC50	=	5.3	5.3	-6	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	340	4	0	3	4.1	O=C1c2ccccc2C(=O)C1C(=O)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4195	14477	None	34	Human	Functional	pAC50	=	5.3	5.3	2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	4195.0	14477	None	34	Human	Functional	pAC50	=	5.3	5.3	2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	CHEMBL1201212	14477	None	34	Human	Functional	pAC50	=	5.3	5.3	2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	DB00211	14477	None	34	Human	Functional	pAC50	=	5.3	5.3	2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	36811	1454	None	27	Human	Functional	pAC50	=	8.3	8.3	-1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	36811.0	1454	None	27	Human	Functional	pAC50	=	8.3	8.3	-1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	535	1454	None	27	Human	Functional	pAC50	=	8.3	8.3	-1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	937	1454	None	27	Human	Functional	pAC50	=	8.3	8.3	-1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL926	1454	None	27	Human	Functional	pAC50	=	8.3	8.3	-1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00841	1454	None	27	Human	Functional	pAC50	=	8.3	8.3	-1	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	3083544	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	3083544.0	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1200811	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1363	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1951071	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL605993	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	DB00983	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	DB01274	26817	None	34	Human	Functional	pAC50	=	7.3	7.3	-407	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	344	9	4	5	2.2	COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1	10.1038/s41467-023-40064-9
	643976	14524	None	29	Human	Functional	pAC50	=	5.3	5.3	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	CHEMBL1201794	14524	None	29	Human	Functional	pAC50	=	5.3	5.3	-2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	456	7	6	10	-1.6	Cc1cc2nc3c(=O)[nH]c(=O)nc-3n(C[C@H](O)[C@H](O)[C@H](O)COP(=O)(O)O)c2cc1C	10.1038/s41467-023-40064-9
	133	2496	None	39	Human	Functional	pAC50	=	7.3	7.3	-131	27	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	1723	2496	None	39	Human	Functional	pAC50	=	7.3	7.3	-131	27	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	28693	2496	None	39	Human	Functional	pAC50	=	7.3	7.3	-131	27	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	CHEMBL19215	2496	None	39	Human	Functional	pAC50	=	7.3	7.3	-131	27	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	DB13520	2496	None	39	Human	Functional	pAC50	=	7.3	7.3	-131	27	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
	3033538	1319	None	27	Human	Functional	pAC50	=	6.3	6.3	-63	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	3033538.0	1319	None	27	Human	Functional	pAC50	=	6.3	6.3	-63	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	7155	1319	None	27	Human	Functional	pAC50	=	6.3	6.3	-63	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	781	1319	None	27	Human	Functional	pAC50	=	6.3	6.3	-63	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1201216	1319	None	27	Human	Functional	pAC50	=	6.3	6.3	-63	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	DB00298	1319	None	27	Human	Functional	pAC50	=	6.3	6.3	-63	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	10.1038/s41467-023-40064-9
	2771	197264	None	50	Human	Functional	pAC50	=	5.3	5.3	-46	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	197264	None	50	Human	Functional	pAC50	=	5.3	5.3	-46	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	197264	None	50	Human	Functional	pAC50	=	5.3	5.3	-46	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	191	403	None	60	Human	Functional	pAC50	=	5.3	5.3	-67	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	None	60	Human	Functional	pAC50	=	5.3	5.3	-67	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	None	60	Human	Functional	pAC50	=	5.3	5.3	-67	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170.0	403	None	60	Human	Functional	pAC50	=	5.3	5.3	-67	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	None	60	Human	Functional	pAC50	=	5.3	5.3	-67	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	None	60	Human	Functional	pAC50	=	5.3	5.3	-67	36	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	107641	61163	None	56	Human	Functional	pAC50	=	5.3	5.3	-2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	4	1	2	3.4	CCC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL1765292	61163	None	56	Human	Functional	pAC50	=	5.3	5.3	-2	2	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	4	1	2	3.4	CCC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	2540	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-1047	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4402	None	68	Human	Functional	pAC50	=	5.3	5.3	-1047	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	11504295	2923	None	40	Human	Functional	pAC50	=	7.3	7.3	-416	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	11504295.0	2923	None	40	Human	Functional	pAC50	=	7.3	7.3	-416	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	None	40	Human	Functional	pAC50	=	7.3	7.3	-416	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	None	40	Human	Functional	pAC50	=	7.3	7.3	-416	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	None	40	Human	Functional	pAC50	=	7.3	7.3	-416	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	None	40	Human	Functional	pAC50	=	7.3	7.3	-416	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	1547484	940	None	51	Human	Functional	pAC50	=	5.3	5.3	-50	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1547484.0	940	None	51	Human	Functional	pAC50	=	5.3	5.3	-50	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	654	940	None	51	Human	Functional	pAC50	=	5.3	5.3	-50	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	9072	940	None	51	Human	Functional	pAC50	=	5.3	5.3	-50	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL43064	940	None	51	Human	Functional	pAC50	=	5.3	5.3	-50	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00568	940	None	51	Human	Functional	pAC50	=	5.3	5.3	-50	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	5639	98949	None	48	Human	Functional	pAC50	=	6.2	6.2	7	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98949	None	48	Human	Functional	pAC50	=	6.2	6.2	7	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	2995	206863	None	31	Human	Functional	pAC50	=	6.2	6.2	-213	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2995.0	206863	None	31	Human	Functional	pAC50	=	6.2	6.2	-213	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	206863	None	31	Human	Functional	pAC50	=	6.2	6.2	-213	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	206863	None	31	Human	Functional	pAC50	=	6.2	6.2	-213	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB01151	206863	None	31	Human	Functional	pAC50	=	6.2	6.2	-213	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	114948	60317	None	11	Human	Functional	pAC50	=	5.2	5.2	-457	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	114948.0	60317	None	11	Human	Functional	pAC50	=	5.2	5.2	-457	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL1743263	60317	None	11	Human	Functional	pAC50	=	5.2	5.2	-457	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	DB11274	60317	None	11	Human	Functional	pAC50	=	5.2	5.2	-457	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	146570	43468	None	43	Human	Functional	pAC50	=	5.2	5.2	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1508	43468	None	43	Human	Functional	pAC50	=	5.2	5.2	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	4167	14506	None	28	Human	Functional	pAC50	=	6.2	6.2	-109	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	4167.0	14506	None	28	Human	Functional	pAC50	=	6.2	6.2	-109	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	CHEMBL1201342	14506	None	28	Human	Functional	pAC50	=	6.2	6.2	-109	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	DB00340	14506	None	28	Human	Functional	pAC50	=	6.2	6.2	-109	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
	2855	4132	None	63	Human	Functional	pAC50	=	5.2	5.2	-2951	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4132	None	63	Human	Functional	pAC50	=	5.2	5.2	-2951	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4132	None	63	Human	Functional	pAC50	=	5.2	5.2	-2951	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717.0	4132	None	63	Human	Functional	pAC50	=	5.2	5.2	-2951	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4132	None	63	Human	Functional	pAC50	=	5.2	5.2	-2951	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4132	None	63	Human	Functional	pAC50	=	5.2	5.2	-2951	12	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Functional	pAC50	=	5.2	5.2	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Functional	pAC50	=	5.2	5.2	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Functional	pAC50	=	5.2	5.2	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Functional	pAC50	=	5.2	5.2	-38	34	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	5832	14466	None	37	Human	Functional	pAC50	=	5.2	5.2	-7	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL1201146	14466	None	37	Human	Functional	pAC50	=	5.2	5.2	-7	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	340	1	0	3	4.1	C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	208898	66220	None	50	Human	Functional	pAC50	=	5.2	5.2	-9	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	208898.0	66220	None	50	Human	Functional	pAC50	=	5.2	5.2	-9	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	CHEMBL184412	66220	None	50	Human	Functional	pAC50	=	5.2	5.2	-9	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	DB04855	66220	None	50	Human	Functional	pAC50	=	5.2	5.2	-9	11	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
	37	778	None	41	Human	Functional	pAC50	=	6.2	6.2	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	None	41	Human	Functional	pAC50	=	6.2	6.2	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	None	41	Human	Functional	pAC50	=	6.2	6.2	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746.0	778	None	41	Human	Functional	pAC50	=	6.2	6.2	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	None	41	Human	Functional	pAC50	=	6.2	6.2	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	None	41	Human	Functional	pAC50	=	6.2	6.2	-141	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	5419	18067	None	45	Human	Functional	pAC50	=	8.2	8.2	10	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
	5419.0	18067	None	45	Human	Functional	pAC50	=	8.2	8.2	10	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL1200413	18067	None	45	Human	Functional	pAC50	=	8.2	8.2	10	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL1266	18067	None	45	Human	Functional	pAC50	=	8.2	8.2	10	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
	DB06764	18067	None	45	Human	Functional	pAC50	=	8.2	8.2	10	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	200	1	1	2	2.1	c1ccc2c(c1)CCCC2C1=NCCN1	10.1038/s41467-023-40064-9
	1028	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816.0	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	1028	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816.0	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	291	None	40	Human	Functional	pAC50	=	8.2	8.2	1	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	1524	2181	None	61	Human	Functional	pAC50	=	7.2	7.2	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	197	2181	None	61	Human	Functional	pAC50	=	7.2	7.2	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3822	2181	None	61	Human	Functional	pAC50	=	7.2	7.2	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3822.0	2181	None	61	Human	Functional	pAC50	=	7.2	7.2	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	88	2181	None	61	Human	Functional	pAC50	=	7.2	7.2	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL51	2181	None	61	Human	Functional	pAC50	=	7.2	7.2	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB12465	2181	None	61	Human	Functional	pAC50	=	7.2	7.2	-23	18	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2713	207729	None	57	Human	Functional	pAC50	=	6.2	6.2	-1	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	207729	None	57	Human	Functional	pAC50	=	6.2	6.2	-1	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	207729	None	57	Human	Functional	pAC50	=	6.2	6.2	-1	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	207729	None	57	Human	Functional	pAC50	=	6.2	6.2	-1	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	207729	None	57	Human	Functional	pAC50	=	6.2	6.2	-1	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	207729	None	57	Human	Functional	pAC50	=	6.2	6.2	-1	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	207729	None	57	Human	Functional	pAC50	=	6.2	6.2	-1	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5324346	208040	None	37	Human	Functional	pAC50	=	5.2	5.2	2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL1409	208040	None	37	Human	Functional	pAC50	=	5.2	5.2	2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	CHEMBL814	208040	None	37	Human	Functional	pAC50	=	5.2	5.2	2	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
	1353	1911	None	63	Human	Functional	pAC50	=	7.2	7.2	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	None	63	Human	Functional	pAC50	=	7.2	7.2	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559.0	1911	None	63	Human	Functional	pAC50	=	7.2	7.2	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	None	63	Human	Functional	pAC50	=	7.2	7.2	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	None	63	Human	Functional	pAC50	=	7.2	7.2	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	None	63	Human	Functional	pAC50	=	7.2	7.2	-23	39	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	102	4127	None	36	Human	Functional	pAC50	=	5.2	5.2	-380	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	None	36	Human	Functional	pAC50	=	5.2	5.2	-380	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	None	36	Human	Functional	pAC50	=	5.2	5.2	-380	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969.0	4127	None	36	Human	Functional	pAC50	=	5.2	5.2	-380	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	None	36	Human	Functional	pAC50	=	5.2	5.2	-380	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	None	36	Human	Functional	pAC50	=	5.2	5.2	-380	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	392622	56328	None	57	Human	Functional	pAC50	=	5.2	5.2	-8	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56328	None	57	Human	Functional	pAC50	=	5.2	5.2	-8	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	3354	41798	None	37	Human	Functional	pAC50	=	5.2	5.2	-7	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	3354.0	41798	None	37	Human	Functional	pAC50	=	5.2	5.2	-7	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	CHEMBL1493	41798	None	37	Human	Functional	pAC50	=	5.2	5.2	-7	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	DB01148	41798	None	37	Human	Functional	pAC50	=	5.2	5.2	-7	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	391	5	0	5	4.4	Cc1c(-c2ccccc2)oc2c(C(=O)OCCN3CCCCC3)cccc2c1=O	10.1038/s41467-023-40064-9
	447715	199383	None	50	Human	Functional	pAC50	=	5.2	5.2	-7	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	CHEMBL566315	199383	None	50	Human	Functional	pAC50	=	5.2	5.2	-7	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	420	5	3	3	5.1	CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O	10.1038/s41467-023-40064-9
	25382	9159	None	27	Human	Functional	pAC50	=	6.2	6.2	-16	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9159	None	27	Human	Functional	pAC50	=	6.2	6.2	-16	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	2435	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-25	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-25	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-25	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-25	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-25	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	2683	102943	None	17	Human	Functional	pAC50	=	5.2	5.2	-812	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL305906	102943	None	17	Human	Functional	pAC50	=	5.2	5.2	-812	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL334255	102943	None	17	Human	Functional	pAC50	=	5.2	5.2	-812	24	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
	2435	722	None	63	Human	Functional	pAC50	=	6.2	6.2	-213	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	2435.0	722	None	63	Human	Functional	pAC50	=	6.2	6.2	-213	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	395	722	None	63	Human	Functional	pAC50	=	6.2	6.2	-213	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	520	722	None	63	Human	Functional	pAC50	=	6.2	6.2	-213	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	5386	722	None	63	Human	Functional	pAC50	=	6.2	6.2	-213	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL844	722	None	63	Human	Functional	pAC50	=	6.2	6.2	-213	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	DB00484	722	None	63	Human	Functional	pAC50	=	6.2	6.2	-213	10	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	10.1038/s41467-023-40064-9
	25295	13625	None	28	Human	Functional	pAC50	=	5.2	5.2	-4	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL1194287	13625	None	28	Human	Functional	pAC50	=	5.2	5.2	-4	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
	10607	204704	None	64	Human	Functional	pAC50	=	5.2	5.2	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	4	1	8	2.4	COc1cc([C@@H]2c3cc4c(cc3[C@H](O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL61	204704	None	64	Human	Functional	pAC50	=	5.2	5.2	-	1	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	414	4	1	8	2.4	COc1cc([C@@H]2c3cc4c(cc3[C@H](O)[C@H]3COC(=O)[C@H]23)OCO4)cc(OC)c1OC	10.1038/s41467-023-40064-9
	73417116	154521	None	0	Human	Functional	pAC50	=	5.2	5.2	-11	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL3989843	154521	None	0	Human	Functional	pAC50	=	5.2	5.2	-11	5	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	266	2	2	2	3.0	N[C@@H]1C[C@H]1c1ccccc1.N[C@H]1C[C@@H]1c1ccccc1	10.1038/s41467-023-40064-9
	5314	206566	None	14	Human	Functional	pAC50	=	6.2	6.2	25	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	290	9	0	4	0.3	C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL703	206566	None	14	Human	Functional	pAC50	=	6.2	6.2	25	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	290	9	0	4	0.3	C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C	10.1038/s41467-023-40064-9
	20628	96601	None	25	Human	Functional	pAC50	=	5.2	5.2	-17	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96601	None	25	Human	Functional	pAC50	=	5.2	5.2	-17	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	2865	4143	None	47	Human	Functional	pAC50	=	6.2	6.2	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	None	47	Human	Functional	pAC50	=	6.2	6.2	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	None	47	Human	Functional	pAC50	=	6.2	6.2	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854.0	4143	None	47	Human	Functional	pAC50	=	6.2	6.2	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	None	47	Human	Functional	pAC50	=	6.2	6.2	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	None	47	Human	Functional	pAC50	=	6.2	6.2	-23	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	5353853	17993	None	30	Human	Functional	pAC50	=	5.2	5.2	-39	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9556529	17993	None	30	Human	Functional	pAC50	=	5.2	5.2	-39	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1262	17993	None	30	Human	Functional	pAC50	=	5.2	5.2	-39	20	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2402	3370	None	38	Human	Functional	pAC50	=	5.2	5.2	-354	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	None	38	Human	Functional	pAC50	=	5.2	5.2	-354	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095.0	3370	None	38	Human	Functional	pAC50	=	5.2	5.2	-354	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	None	38	Human	Functional	pAC50	=	5.2	5.2	-354	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	None	38	Human	Functional	pAC50	=	5.2	5.2	-354	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	None	38	Human	Functional	pAC50	=	5.2	5.2	-354	17	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	1593	2340	None	41	Human	Functional	pAC50	=	8.2	8.2	-3	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	30668	2340	None	41	Human	Functional	pAC50	=	8.2	8.2	-3	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	30668.0	2340	None	41	Human	Functional	pAC50	=	8.2	8.2	-3	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	9868	2340	None	41	Human	Functional	pAC50	=	8.2	8.2	-3	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL17860	2340	None	41	Human	Functional	pAC50	=	8.2	8.2	-3	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	DB04948	2340	None	41	Human	Functional	pAC50	=	8.2	8.2	-3	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	258	3	1	3	2.8	CC(C1=NCCN1)Oc1c(Cl)cccc1Cl	10.1038/s41467-023-40064-9
	4567	9950	None	29	Human	Functional	pAC50	=	7.2	7.2	2	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9950	None	29	Human	Functional	pAC50	=	7.2	7.2	2	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	16363	596	None	33	Human	Functional	pAC50	=	7.2	7.2	-13	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16363.0	596	None	33	Human	Functional	pAC50	=	7.2	7.2	-13	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	None	33	Human	Functional	pAC50	=	7.2	7.2	-13	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	None	33	Human	Functional	pAC50	=	7.2	7.2	-13	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	None	33	Human	Functional	pAC50	=	7.2	7.2	-13	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	None	33	Human	Functional	pAC50	=	7.2	7.2	-13	21	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	168871	89164	None	10	Human	Functional	pAC50	=	6.2	6.2	-53	13	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89164	None	10	Human	Functional	pAC50	=	6.2	6.2	-53	13	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	3598	187927	None	45	Human	Functional	pAC50	=	6.2	6.2	1	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL496	187927	None	45	Human	Functional	pAC50	=	6.2	6.2	1	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-26	42	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	40466858	16162	None	49	Human	Functional	pAC50	=	6.2	6.2	-20	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
	5284514	16162	None	49	Human	Functional	pAC50	=	6.2	6.2	-20	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
	5284514.0	16162	None	49	Human	Functional	pAC50	=	6.2	6.2	-20	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1224	16162	None	49	Human	Functional	pAC50	=	6.2	6.2	-20	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
	DB09488	16162	None	49	Human	Functional	pAC50	=	6.2	6.2	-20	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	348	6	1	3	4.0	Cc1ccc(/C(=C\CN2CCCC2)c2cccc(/C=C/C(=O)O)n2)cc1	10.1038/s41467-023-40064-9
	5077	3578	None	61	Human	Functional	pAC50	=	5.1	5.1	-275	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3578	None	61	Human	Functional	pAC50	=	5.1	5.1	-275	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3578	None	61	Human	Functional	pAC50	=	5.1	5.1	-275	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767.0	3578	None	61	Human	Functional	pAC50	=	5.1	5.1	-275	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3578	None	61	Human	Functional	pAC50	=	5.1	5.1	-275	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3578	None	61	Human	Functional	pAC50	=	5.1	5.1	-275	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	1613	2348	None	42	Human	Functional	pAC50	=	7.1	7.1	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	None	42	Human	Functional	pAC50	=	7.1	7.1	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	None	42	Human	Functional	pAC50	=	7.1	7.1	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964.0	2348	None	42	Human	Functional	pAC50	=	7.1	7.1	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	None	42	Human	Functional	pAC50	=	7.1	7.1	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	None	42	Human	Functional	pAC50	=	7.1	7.1	-10	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4195	14477	None	34	Human	Functional	pAC50	=	5.1	5.1	2	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	4195.0	14477	None	34	Human	Functional	pAC50	=	5.1	5.1	2	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	CHEMBL1201212	14477	None	34	Human	Functional	pAC50	=	5.1	5.1	2	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	DB00211	14477	None	34	Human	Functional	pAC50	=	5.1	5.1	2	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	254	6	3	5	-0.2	COc1ccc(OC)c(C(O)CNC(=O)CN)c1	10.1038/s41467-023-40064-9
	12488	1657	None	39	Human	Functional	pAC50	=	6.1	6.1	-19	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	941361	1657	None	39	Human	Functional	pAC50	=	6.1	6.1	-19	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	CHEMBL30008	1657	None	39	Human	Functional	pAC50	=	6.1	6.1	-19	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	DB04841	1657	None	39	Human	Functional	pAC50	=	6.1	6.1	-19	28	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
	1909	2822	None	46	Human	Functional	pAC50	=	6.1	6.1	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	2559	2822	None	46	Human	Functional	pAC50	=	6.1	6.1	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	4474	2822	None	46	Human	Functional	pAC50	=	6.1	6.1	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL1484	2822	None	46	Human	Functional	pAC50	=	6.1	6.1	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	CHEMBL3302409	2822	None	46	Human	Functional	pAC50	=	6.1	6.1	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	DB00622	2822	None	46	Human	Functional	pAC50	=	6.1	6.1	-1	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
	82146	4532	None	68	Human	Functional	pAC50	=	6.1	6.1	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1023	4532	None	68	Human	Functional	pAC50	=	6.1	6.1	1	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
	213046	2385	None	44	Human	Functional	pAC50	=	7.1	7.1	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	213046.0	2385	None	44	Human	Functional	pAC50	=	7.1	7.1	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	None	44	Human	Functional	pAC50	=	7.1	7.1	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	None	44	Human	Functional	pAC50	=	7.1	7.1	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	None	44	Human	Functional	pAC50	=	7.1	7.1	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	None	44	Human	Functional	pAC50	=	7.1	7.1	-6	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	137	370	None	37	Human	Functional	pAC50	=	5.1	5.1	-3467	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	370	None	37	Human	Functional	pAC50	=	5.1	5.1	-3467	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	370	None	37	Human	Functional	pAC50	=	5.1	5.1	-3467	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	370	None	37	Human	Functional	pAC50	=	5.1	5.1	-3467	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	370	None	37	Human	Functional	pAC50	=	5.1	5.1	-3467	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	370	None	37	Human	Functional	pAC50	=	5.1	5.1	-3467	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	68617	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-14	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-14	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-14	30	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	11823027	192725	None	29	Human	Functional	pAC50	=	5.1	5.1	-436	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	11823027.0	192725	None	29	Human	Functional	pAC50	=	5.1	5.1	-436	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	4411	192725	None	29	Human	Functional	pAC50	=	5.1	5.1	-436	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	4411.0	192725	None	29	Human	Functional	pAC50	=	5.1	5.1	-436	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	CHEMBL3246778	192725	None	29	Human	Functional	pAC50	=	5.1	5.1	-436	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	CHEMBL521606	192725	None	29	Human	Functional	pAC50	=	5.1	5.1	-436	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	DB01203	192725	None	29	Human	Functional	pAC50	=	5.1	5.1	-436	3	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	309	5	4	5	0.6	CC(C)(C)NCC(O)COc1cccc2c1CC(O)C(O)C2	10.1038/s41467-023-40064-9
	1690	3058	None	10	Human	Functional	pAC50	=	5.1	5.1	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	247	3	0	3	2.2	CCOC(=O)C1(CCN(CC1)C)c1ccccc1	10.1038/s41467-023-40064-9
	4058	3058	None	10	Human	Functional	pAC50	=	5.1	5.1	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	247	3	0	3	2.2	CCOC(=O)C1(CCN(CC1)C)c1ccccc1	10.1038/s41467-023-40064-9
	4058.0	3058	None	10	Human	Functional	pAC50	=	5.1	5.1	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	247	3	0	3	2.2	CCOC(=O)C1(CCN(CC1)C)c1ccccc1	10.1038/s41467-023-40064-9
	5750	3058	None	10	Human	Functional	pAC50	=	5.1	5.1	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	247	3	0	3	2.2	CCOC(=O)C1(CCN(CC1)C)c1ccccc1	10.1038/s41467-023-40064-9
	7221	3058	None	10	Human	Functional	pAC50	=	5.1	5.1	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	247	3	0	3	2.2	CCOC(=O)C1(CCN(CC1)C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL607	3058	None	10	Human	Functional	pAC50	=	5.1	5.1	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	247	3	0	3	2.2	CCOC(=O)C1(CCN(CC1)C)c1ccccc1	10.1038/s41467-023-40064-9
	DB00454	3058	None	10	Human	Functional	pAC50	=	5.1	5.1	-2	4	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	247	3	0	3	2.2	CCOC(=O)C1(CCN(CC1)C)c1ccccc1	10.1038/s41467-023-40064-9
	2291	3184	None	43	Human	Functional	pAC50	=	5.1	5.1	-147	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2561	3184	None	43	Human	Functional	pAC50	=	5.1	5.1	-147	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932	3184	None	43	Human	Functional	pAC50	=	5.1	5.1	-147	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932.0	3184	None	43	Human	Functional	pAC50	=	5.1	5.1	-147	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL631	3184	None	43	Human	Functional	pAC50	=	5.1	5.1	-147	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB01182	3184	None	43	Human	Functional	pAC50	=	5.1	5.1	-147	13	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	1588	2325	None	21	Human	Functional	pAC50	=	7.1	7.1	-467	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	28864	2325	None	21	Human	Functional	pAC50	=	7.1	7.1	-467	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	28864.0	2325	None	21	Human	Functional	pAC50	=	7.1	7.1	-467	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	43	2325	None	21	Human	Functional	pAC50	=	7.1	7.1	-467	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL157138	2325	None	21	Human	Functional	pAC50	=	7.1	7.1	-467	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB00589	2325	None	21	Human	Functional	pAC50	=	7.1	7.1	-467	23	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	82146	4532	None	68	Human	Functional	pAC50	=	5.1	5.1	1	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
	CHEMBL1023	4532	None	68	Human	Functional	pAC50	=	5.1	5.1	1	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
	2803	955	None	40	Human	Functional	pAC50	=	8.1	8.1	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	2803.0	955	None	40	Human	Functional	pAC50	=	8.1	8.1	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	516	955	None	40	Human	Functional	pAC50	=	8.1	8.1	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	704	955	None	40	Human	Functional	pAC50	=	8.1	8.1	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	CHEMBL134	955	None	40	Human	Functional	pAC50	=	8.1	8.1	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	DB00575	955	None	40	Human	Functional	pAC50	=	8.1	8.1	-3	14	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	7.1	7.1	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	7.1	7.1	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	7.1	7.1	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	7.1	7.1	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	7.1	7.1	-13803	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	154257	178724	None	43	Human	Functional	pAC50	=	5.1	5.1	-13	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178724	None	43	Human	Functional	pAC50	=	5.1	5.1	-13	19	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	6324616	168927	None	18	Human	Functional	pAC50	=	5.1	5.1	1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	697	2	6	12	4.8	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(cc(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	CHEMBL437765	168927	None	18	Human	Functional	pAC50	=	5.1	5.1	1	3	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	697	2	6	12	4.8	CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(cc(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C	10.1038/s41467-023-40064-9
	3949	100668	None	35	Human	Functional	pAC50	=	5.1	5.1	-8	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100668	None	35	Human	Functional	pAC50	=	5.1	5.1	-8	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	444029	167860	None	7	Human	Functional	pAC50	=	5.1	5.1	-1	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	509	6	2	9	2.0	C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]2(C)O1	10.1038/s41467-023-40064-9
	CHEMBL4303178	167860	None	7	Human	Functional	pAC50	=	5.1	5.1	-1	2	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	509	6	2	9	2.0	C=C[C@@]1(C)CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@@H]3[C@H](OC(=O)CCN(C)C)[C@H](OC(C)=O)[C@@]2(C)O1	10.1038/s41467-023-40064-9
	4631	197216	None	23	Human	Functional	pAC50	=	5.1	5.1	-1071	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	4631.0	197216	None	23	Human	Functional	pAC50	=	5.1	5.1	-1071	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL546	197216	None	23	Human	Functional	pAC50	=	5.1	5.1	-1071	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	DB01580	197216	None	23	Human	Functional	pAC50	=	5.1	5.1	-1071	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	265	9	2	4	2.0	C=CCOc1ccccc1OCC(O)CNC(C)C	10.1038/s41467-023-40064-9
	71398	106495	None	32	Human	Functional	pAC50	=	5.1	5.1	-1174	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106495	None	32	Human	Functional	pAC50	=	5.1	5.1	-1174	14	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	6.1	6.1	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	6.1	6.1	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	6.1	6.1	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	6.1	6.1	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	6.1	6.1	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	6.1	6.1	-199	29	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	11057	176253	None	16	Human	Functional	pAC50	=	6.1	6.1	-1	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	3468	176253	None	16	Human	Functional	pAC50	=	6.1	6.1	-1	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL459265	176253	None	16	Human	Functional	pAC50	=	6.1	6.1	-1	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL64894	176253	None	16	Human	Functional	pAC50	=	6.1	6.1	-1	25	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
	636403	188375	None	19	Human	Functional	pAC50	=	5.1	5.1	-3	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188375	None	19	Human	Functional	pAC50	=	5.1	5.1	-3	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	124087	1389	None	72	Human	Functional	pAC50	=	5.1	5.1	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	124087.0	1389	None	72	Human	Functional	pAC50	=	5.1	5.1	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	None	72	Human	Functional	pAC50	=	5.1	5.1	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	None	72	Human	Functional	pAC50	=	5.1	5.1	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	None	72	Human	Functional	pAC50	=	5.1	5.1	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	None	72	Human	Functional	pAC50	=	5.1	5.1	-112	27	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	41684	31229	None	62	Human	Functional	pAC50	=	5.1	5.1	-19	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31229	None	62	Human	Functional	pAC50	=	5.1	5.1	-19	32	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	5284550	41735	None	12	Human	Functional	pAC50	=	6.1	6.1	-87	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	5284550.0	41735	None	12	Human	Functional	pAC50	=	6.1	6.1	-87	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL108947	41735	None	12	Human	Functional	pAC50	=	6.1	6.1	-87	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41735	None	12	Human	Functional	pAC50	=	6.1	6.1	-87	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	DB09167	41735	None	12	Human	Functional	pAC50	=	6.1	6.1	-87	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	21855	84280	None	37	Human	Functional	pAC50	=	5.1	5.1	-112	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	21855.0	84280	None	37	Human	Functional	pAC50	=	5.1	5.1	-112	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	CHEMBL22108	84280	None	37	Human	Functional	pAC50	=	5.1	5.1	-112	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	DB08801	84280	None	37	Human	Functional	pAC50	=	5.1	5.1	-112	9	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
	134	2514	None	19	Human	Functional	pAC50	=	6.1	6.1	-457	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2514	None	19	Human	Functional	pAC50	=	6.1	6.1	-457	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2514	None	19	Human	Functional	pAC50	=	6.1	6.1	-457	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681.0	2514	None	19	Human	Functional	pAC50	=	6.1	6.1	-457	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2514	None	19	Human	Functional	pAC50	=	6.1	6.1	-457	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2514	None	19	Human	Functional	pAC50	=	6.1	6.1	-457	18	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	2391	209912	None	61	Human	Functional	pAC50	=	5.1	5.1	-9	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	361	5	0	5	4.1	CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1	10.1038/s41467-023-40064-9
	CHEMBL942	209912	None	61	Human	Functional	pAC50	=	5.1	5.1	-9	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	361	5	0	5	4.1	CC(=O)Oc1ccc(C(c2ccc(OC(C)=O)cc2)c2ccccn2)cc1	10.1038/s41467-023-40064-9
	151537	162759	None	30	Human	Functional	pAC50	=	5.1	5.1	-1	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	41867	162759	None	30	Human	Functional	pAC50	=	5.1	5.1	-1	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL417	162759	None	30	Human	Functional	pAC50	=	5.1	5.1	-1	4	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	3294	2006	None	61	Human	Functional	pAC50	=	8.0	8.0	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	None	61	Human	Functional	pAC50	=	8.0	8.0	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360.0	2006	None	61	Human	Functional	pAC50	=	8.0	8.0	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	None	61	Human	Functional	pAC50	=	8.0	8.0	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	None	61	Human	Functional	pAC50	=	8.0	8.0	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	None	61	Human	Functional	pAC50	=	8.0	8.0	-3	23	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	1343	1889	None	43	Human	Functional	pAC50	=	8.0	8.0	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	None	43	Human	Functional	pAC50	=	8.0	8.0	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519.0	1889	None	43	Human	Functional	pAC50	=	8.0	8.0	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	None	43	Human	Functional	pAC50	=	8.0	8.0	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	None	43	Human	Functional	pAC50	=	8.0	8.0	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	None	43	Human	Functional	pAC50	=	8.0	8.0	-9	12	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	2683	3834	None	40	Human	Functional	pAC50	=	8.0	8.0	-10	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	5487	3834	None	40	Human	Functional	pAC50	=	8.0	8.0	-10	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	5487.0	3834	None	40	Human	Functional	pAC50	=	8.0	8.0	-10	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	7308	3834	None	40	Human	Functional	pAC50	=	8.0	8.0	-10	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	CHEMBL1079	3834	None	40	Human	Functional	pAC50	=	8.0	8.0	-10	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	DB00697	3834	None	40	Human	Functional	pAC50	=	8.0	8.0	-10	6	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	10.1038/s41467-023-40064-9
	4209	3163	None	48	Human	Functional	pAC50	=	8	8.0	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	None	48	Human	Functional	pAC50	=	8	8.0	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893.0	3163	None	48	Human	Functional	pAC50	=	8	8.0	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	None	48	Human	Functional	pAC50	=	8	8.0	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	None	48	Human	Functional	pAC50	=	8	8.0	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	None	48	Human	Functional	pAC50	=	8	8.0	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	None	48	Human	Functional	pAC50	=	8	8.0	-24	17	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	12574	2605	None	60	Human	Functional	pAC50	=	7.1	7.1	-1	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810	2605	None	60	Human	Functional	pAC50	=	7.1	7.1	-1	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	4810.0	2605	None	60	Human	Functional	pAC50	=	7.1	7.1	-1	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	CHEMBL19236	2605	None	60	Human	Functional	pAC50	=	7.1	7.1	-1	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	DB09242	2605	None	60	Human	Functional	pAC50	=	7.1	7.1	-1	8	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	241	2	2	6	0.8	CC1=NC(=C(C(=N1)Cl)NC2=NCCN2)OC	10.1038/s41467-023-40064-9
	2419	3463	None	53	Human	Functional	pAC50	=	6.0	6.0	-2511	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3463	None	53	Human	Functional	pAC50	=	6.0	6.0	-2511	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152.0	3463	None	53	Human	Functional	pAC50	=	6.0	6.0	-2511	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3463	None	53	Human	Functional	pAC50	=	6.0	6.0	-2511	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3463	None	53	Human	Functional	pAC50	=	6.0	6.0	-2511	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3463	None	53	Human	Functional	pAC50	=	6.0	6.0	-2511	19	Agonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human ADRA1A in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	25102847	78250	None	62	Human	Functional	pAC50	=	5.0	5.0	-7	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78250	None	62	Human	Functional	pAC50	=	5.0	5.0	-7	10	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	3397	207946	None	70	Human	Functional	pAC50	=	5.0	5.0	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	3.2	CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL806	207946	None	70	Human	Functional	pAC50	=	5.0	5.0	-1	7	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	276	3	1	3	3.2	CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	135398745	2914	None	65	Human	Functional	pAC50	=	6.0	6.0	-14	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135398745.0	2914	None	65	Human	Functional	pAC50	=	6.0	6.0	-14	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	None	65	Human	Functional	pAC50	=	6.0	6.0	-14	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	None	65	Human	Functional	pAC50	=	6.0	6.0	-14	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	None	65	Human	Functional	pAC50	=	6.0	6.0	-14	33	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	277	1301	None	39	Human	Functional	pAC50	=	6.0	6.0	-954	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2913	1301	None	39	Human	Functional	pAC50	=	6.0	6.0	-954	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2913.0	1301	None	39	Human	Functional	pAC50	=	6.0	6.0	-954	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	765	1301	None	39	Human	Functional	pAC50	=	6.0	6.0	-954	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL516	1301	None	39	Human	Functional	pAC50	=	6.0	6.0	-954	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB00434	1301	None	39	Human	Functional	pAC50	=	6.0	6.0	-954	29	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	610479	15507	None	60	Human	Functional	pAC50	=	5.0	5.0	1	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL121626	15507	None	60	Human	Functional	pAC50	=	5.0	5.0	1	5	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	261	3	2	2	4.1	Cc1c(Cl)cccc1Nc1ccccc1C(=O)O	10.1038/s41467-023-40064-9
	3280	48463	None	17	Human	Functional	pAC50	=	5.0	5.0	-5	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
	CHEMBL1555736	48463	None	17	Human	Functional	pAC50	=	5.0	5.0	-5	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
	3166	169523	None	18	Human	Functional	pAC50	=	5.0	5.0	-1230	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL442444	169523	None	18	Human	Functional	pAC50	=	5.0	5.0	-1230	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
	2583	3776	None	69	Human	Functional	pAC50	=	5.0	5.0	-3019	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	None	69	Human	Functional	pAC50	=	5.0	5.0	-3019	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	None	69	Human	Functional	pAC50	=	5.0	5.0	-3019	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999.0	3776	None	69	Human	Functional	pAC50	=	5.0	5.0	-3019	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	None	69	Human	Functional	pAC50	=	5.0	5.0	-3019	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	None	69	Human	Functional	pAC50	=	5.0	5.0	-3019	16	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	1201549	597	None	17	Human	Functional	pAC50	=	6.0	6.0	-138	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1201549.0	597	None	17	Human	Functional	pAC50	=	6.0	6.0	-138	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	None	17	Human	Functional	pAC50	=	6.0	6.0	-138	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	None	17	Human	Functional	pAC50	=	6.0	6.0	-138	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	None	17	Human	Functional	pAC50	=	6.0	6.0	-138	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	None	17	Human	Functional	pAC50	=	6.0	6.0	-138	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	None	17	Human	Functional	pAC50	=	6.0	6.0	-138	26	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2600	3779	None	53	Human	Functional	pAC50	=	5.0	5.0	-151	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3779	None	53	Human	Functional	pAC50	=	5.0	5.0	-151	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3779	None	53	Human	Functional	pAC50	=	5.0	5.0	-151	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3779	None	53	Human	Functional	pAC50	=	5.0	5.0	-151	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3779	None	53	Human	Functional	pAC50	=	5.0	5.0	-151	32	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	1400	1957	None	46	Human	Functional	pAC50	=	5.0	5.0	-15	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1957	None	46	Human	Functional	pAC50	=	5.0	5.0	-15	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658.0	1957	None	46	Human	Functional	pAC50	=	5.0	5.0	-15	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1957	None	46	Human	Functional	pAC50	=	5.0	5.0	-15	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1957	None	46	Human	Functional	pAC50	=	5.0	5.0	-15	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1957	None	46	Human	Functional	pAC50	=	5.0	5.0	-15	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1957	None	46	Human	Functional	pAC50	=	5.0	5.0	-15	16	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3678	94845	None	37	Human	Functional	pAC50	=	6.0	6.0	-33	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	3678.0	94845	None	37	Human	Functional	pAC50	=	6.0	6.0	-33	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL253371	94845	None	37	Human	Functional	pAC50	=	6.0	6.0	-33	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	DB01616	94845	None	37	Human	Functional	pAC50	=	6.0	6.0	-33	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
	7019	168079	None	72	Human	Functional	pAC50	=	5.0	5.0	-2	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL1308088	168079	None	72	Human	Functional	pAC50	=	5.0	5.0	-2	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	CHEMBL43184	168079	None	72	Human	Functional	pAC50	=	5.0	5.0	-2	8	Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopyAntagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
	150311	9814	None	69	Human	Functional	pAC50	=	5	5.0	-2	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL1138	9814	None	69	Human	Functional	pAC50	=	5	5.0	-2	7	Agonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopyAgonist activity at human ADRA1A in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
	10934575	206944	None	0	Human	Functional	pEC50	=	10.0	10.0	3	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL72441	206944	None	0	Human	Functional	pEC50	=	10.0	10.0	3	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	235	4	2	4	2.1	CSc1ccc(C)cc1NCC1=NCCN1	10.1021/jm000542r
	44362146	165029	None	0	Human	Functional	pEC50	=	9.6	9.6	50	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	258	4	1	4	2.8	c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL422477	165029	None	0	Human	Functional	pEC50	=	9.6	9.6	50	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	258	4	1	4	2.8	c1ccc(-c2ccsc2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	44574074	189578	None	0	Human	Functional	pEC50	=	9.4	9.4	977	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	262	2	0	4	2.7	c1ccc([C@@H]2Cc3nccn3C2)c(-c2cncnc2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL513691	189578	None	0	Human	Functional	pEC50	=	9.4	9.4	977	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	262	2	0	4	2.7	c1ccc([C@@H]2Cc3nccn3C2)c(-c2cncnc2)c1	10.1016/j.bmcl.2009.03.166
	11109088	206638	None	0	Human	Functional	pEC50	=	9.4	9.4	1	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70751	206638	None	0	Human	Functional	pEC50	=	9.4	9.4	1	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	255	4	2	4	2.5	CSc1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	22493318	44771	None	0	Human	Functional	pEC50	=	9.3	9.3	13	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	241	4	2	4	2.4	c1coc(-c2ccccc2NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	CHEMBL152155	44771	None	0	Human	Functional	pEC50	=	9.3	9.3	13	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	241	4	2	4	2.4	c1coc(-c2ccccc2NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	44362194	34391	None	0	Human	Functional	pEC50	=	9.3	9.3	10	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	1	4	2.3	c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL142784	34391	None	0	Human	Functional	pEC50	=	9.3	9.3	10	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	1	4	2.3	c1ccc(-c2ccoc2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	22493352	48288	None	0	Human	Functional	pEC50	=	9.2	9.2	2	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2ncco2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	CHEMBL155326	48288	None	0	Human	Functional	pEC50	=	9.2	9.2	2	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2ncco2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	22493236	60416	None	0	Human	Functional	pEC50	=	9.1	9.1	5	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	242	4	3	5	0.9	c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(03)00050-7
	CHEMBL17491	60416	None	0	Human	Functional	pEC50	=	9.1	9.1	5	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	242	4	3	5	0.9	c1ccc(-c2nc[nH]n2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(03)00050-7
	44271661	161890	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	233	4	2	5	0.9	COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL414185	161890	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	233	4	2	5	0.9	COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44271661	161890	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Effective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determined	ChEMBL	233	4	2	5	0.9	COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL414185	161890	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	Effective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determinedEffective concentration showing agonistic activity towards Human alpha-1A adrenergic receptor, expressed in rat 1 fibroblast cells was determined	ChEMBL	233	4	2	5	0.9	COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	22493280	48289	None	0	Human	Functional	pEC50	=	9.1	9.1	1	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2ccno2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	CHEMBL155327	48289	None	0	Human	Functional	pEC50	=	9.1	9.1	1	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2ccno2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	44271661	161890	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	233	4	2	5	0.9	COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL414185	161890	None	0	Human	Functional	pEC50	=	9.1	9.1	-1	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	233	4	2	5	0.9	COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	44369431	45369	None	0	Human	Functional	pEC50	=	9.1	9.1	57	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	271	4	2	4	3.1	Cc1ccsc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL152693	45369	None	0	Human	Functional	pEC50	=	9.1	9.1	57	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	271	4	2	4	3.1	Cc1ccsc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	44362208	35442	None	0	Human	Functional	pEC50	=	9	9.0	3	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	258	4	1	4	2.8	c1csc(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL143801	35442	None	0	Human	Functional	pEC50	=	9	9.0	3	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	258	4	1	4	2.8	c1csc(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	22493258	98717	None	0	Human	Functional	pEC50	=	9	9.0	5	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	241	4	3	4	1.5	c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(03)00050-7
	CHEMBL277375	98717	None	0	Human	Functional	pEC50	=	9	9.0	5	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	241	4	3	4	1.5	c1ccc(-c2cc[nH]n2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(03)00050-7
	44574078	178866	None	0	Human	Functional	pEC50	=	9	9.0	120	3	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	0	3	3.3	c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL468711	178866	None	0	Human	Functional	pEC50	=	9	9.0	120	3	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	0	3	3.3	c1cncc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	44219718	188954	None	0	Human	Functional	pEC50	=	9	9.0	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	280	2	0	4	2.8	Fc1ccc(-c2cncnc2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL506744	188954	None	0	Human	Functional	pEC50	=	9	9.0	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	280	2	0	4	2.8	Fc1ccc(-c2cncnc2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	44362286	98940	None	0	Human	Functional	pEC50	=	8.9	8.9	7	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	1	4	2.3	c1coc(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL279136	98940	None	0	Human	Functional	pEC50	=	8.9	8.9	7	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	1	4	2.3	c1coc(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	44362195	121153	None	0	Human	Functional	pEC50	=	8.9	8.9	2	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	241	4	2	3	2.1	c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL357129	121153	None	0	Human	Functional	pEC50	=	8.9	8.9	2	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	241	4	2	3	2.1	c1c[nH]c(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	22493263	98137	None	0	Human	Functional	pEC50	=	8.9	8.9	50	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	270	5	2	6	1.4	CCn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL273316	98137	None	0	Human	Functional	pEC50	=	8.9	8.9	50	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	270	5	2	6	1.4	CCn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	22493365	98517	None	0	Human	Functional	pEC50	=	8.9	8.9	15	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	241	4	3	4	1.5	c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(03)00050-7
	CHEMBL275844	98517	None	0	Human	Functional	pEC50	=	8.9	8.9	15	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	241	4	3	4	1.5	c1ccc(-c2cn[nH]c2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(03)00050-7
	44329788	210561	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	6	2	5	2.1	CCC(C)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL97859	210561	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	6	2	5	2.1	CCC(C)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	11098175	206628	None	0	Human	Functional	pEC50	=	8.8	8.8	2	4	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL70691	206628	None	0	Human	Functional	pEC50	=	8.8	8.8	2	4	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	251	5	2	5	1.8	COc1ccc(SC)c(NCC2=NCCN2)c1	10.1021/jm000542r
	10221005	206780	None	0	Human	Functional	pEC50	=	8.7	8.7	72	3	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	267	4	2	5	0.8	Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL71479	206780	None	0	Human	Functional	pEC50	=	8.7	8.7	72	3	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	267	4	2	5	0.8	Cc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	44362185	121093	None	0	Human	Functional	pEC50	=	8.7	8.7	19	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	253	4	1	4	2.1	c1cncc(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL356605	121093	None	0	Human	Functional	pEC50	=	8.7	8.7	19	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	253	4	1	4	2.1	c1cncc(-c2ccccc2OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	22493343	63992	None	0	Human	Functional	pEC50	=	8.7	8.7	19	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	256	4	2	6	0.9	Cn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL18069	63992	None	0	Human	Functional	pEC50	=	8.7	8.7	19	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	256	4	2	6	0.9	Cn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	44343410	11559	None	1	Human	Functional	pEC50	=	8	8.0	-1	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	219	4	2	3	2.7	CSc1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	CHEMBL118055	11559	None	1	Human	Functional	pEC50	=	8	8.0	-1	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	219	4	2	3	2.7	CSc1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	9837963	62991	None	0	Human	Functional	pEC50	=	8	8.0	8	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL17851	62991	None	0	Human	Functional	pEC50	=	8	8.0	8	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	44329796	210838	None	0	Human	Functional	pEC50	=	8	8.0	1	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	7	2	5	2.1	CCCCOC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL99559	210838	None	0	Human	Functional	pEC50	=	8	8.0	1	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	7	2	5	2.1	CCCCOC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	22493289	49702	None	0	Human	Functional	pEC50	=	8	8.0	4	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	253	4	2	5	1.6	c1cnc(-c2ccccc2NCC2=NCCN2)nc1	10.1016/s0960-894x(01)00822-8
	CHEMBL156661	49702	None	0	Human	Functional	pEC50	=	8	8.0	4	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	253	4	2	5	1.6	c1cnc(-c2ccccc2NCC2=NCCN2)nc1	10.1016/s0960-894x(01)00822-8
	11034737	206986	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	4	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	289	4	2	4	2.8	CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL72724	206986	None	0	Human	Functional	pEC50	=	8.0	8.0	-1	4	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	289	4	2	4	2.8	CSc1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
	44362145	34492	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	2	4	1.5	c1ccc(-c2ncc[nH]2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL142864	34492	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	2	4	1.5	c1ccc(-c2ncc[nH]2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	22493401	210708	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	288	7	2	4	2.0	CCCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL98769	210708	None	0	Human	Functional	pEC50	=	7	7.0	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	288	7	2	4	2.0	CCCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	22493225	62532	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	270	4	2	6	1.2	Cc1nc(-c2ccccc2NCC2=NCCN2)n(C)n1	10.1016/s0960-894x(03)00050-7
	CHEMBL17819	62532	None	0	Human	Functional	pEC50	=	6	6.0	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	270	4	2	6	1.2	Cc1nc(-c2ccccc2NCC2=NCCN2)n(C)n1	10.1016/s0960-894x(03)00050-7
	44574878	178652	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	2	1	2	2.7	COc1cccc(C2CCc3nc[nH]c3C2)c1	10.1016/j.bmcl.2009.03.162
	CHEMBL466916	178652	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	2	1	2	2.7	COc1cccc(C2CCc3nc[nH]c3C2)c1	10.1016/j.bmcl.2009.03.162
	22493372	120302	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1ncc(-c2ccccc2NCC2=NCCN2)o1	10.1016/s0960-894x(01)00822-8
	CHEMBL352225	120302	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1ncc(-c2ccccc2NCC2=NCCN2)o1	10.1016/s0960-894x(01)00822-8
	11059195	102227	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	321	4	2	5	1.5	CS(=O)(=O)c1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL302698	102227	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	321	4	2	5	1.5	CS(=O)(=O)c1ccc(C(F)(F)F)cc1NCC1=NCCN1	10.1021/jm000542r
	44574987	178782	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	3	0	3	2.8	FC(F)Oc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL467915	178782	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	3	0	3	2.8	FC(F)Oc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	76632	100104	None	24	Human	Functional	pEC50	=	5.0	5.0	-5	2	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	181	4	1	3	1.2	COc1ccc(OC)c(CCN)c1	10.1021/jm00144a012
	CHEMBL287047	100104	None	24	Human	Functional	pEC50	=	5.0	5.0	-5	2	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	181	4	1	3	1.2	COc1ccc(OC)c(CCN)c1	10.1021/jm00144a012
	44449657	96119	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	265	2	1	3	3.5	Cc1oncc1-c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL260009	96119	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	265	2	1	3	3.5	Cc1oncc1-c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44571891	170119	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	280	3	1	4	2.8	Cc1noc(Cc2cccc3c2CC[C@H]3c2ncc[nH]2)n1	10.1016/j.bmcl.2008.10.066
	CHEMBL444252	170119	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	280	3	1	4	2.8	Cc1noc(Cc2cccc3c2CC[C@H]3c2ncc[nH]2)n1	10.1016/j.bmcl.2008.10.066
	2435	722	None	63	Bovine	Functional	pEC50	=	6.0	6.0	-26	10	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	2435.0	722	None	63	Bovine	Functional	pEC50	=	6.0	6.0	-26	10	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	395	722	None	63	Bovine	Functional	pEC50	=	6.0	6.0	-26	10	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	520	722	None	63	Bovine	Functional	pEC50	=	6.0	6.0	-26	10	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	5386	722	None	63	Bovine	Functional	pEC50	=	6.0	6.0	-26	10	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	CHEMBL844	722	None	63	Bovine	Functional	pEC50	=	6.0	6.0	-26	10	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	DB00484	722	None	63	Bovine	Functional	pEC50	=	6.0	6.0	-26	10	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	291	1	2	5	1.8	Brc1c(ccc2c1nccn2)NC1=NCCN1	nan
	44449690	96214	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	1	2	3.6	c1ccc(-c2cccc3c2CCC3c2ncc[nH]2)nc1	10.1016/j.bmcl.2008.03.070
	CHEMBL260575	96214	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	1	2	3.6	c1ccc(-c2cccc3c2CCC3c2ncc[nH]2)nc1	10.1016/j.bmcl.2008.03.070
	1960	2857	None	46	Rat	Functional	pEC50	=	5.9	5.9	-93	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	439260	2857	None	46	Rat	Functional	pEC50	=	5.9	5.9	-93	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	439260.0	2857	None	46	Rat	Functional	pEC50	=	5.9	5.9	-93	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	505	2857	None	46	Rat	Functional	pEC50	=	5.9	5.9	-93	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	CHEMBL1437	2857	None	46	Rat	Functional	pEC50	=	5.9	5.9	-93	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	DB00368	2857	None	46	Rat	Functional	pEC50	=	5.9	5.9	-93	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	44574105	178913	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	305	5	1	4	1.3	CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
	CHEMBL469127	178913	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	305	5	1	4	1.3	CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
	44574045	189395	None	0	Human	Functional	pEC50	=	7.9	7.9	60	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	260	2	0	2	3.9	c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.166
	CHEMBL512062	189395	None	0	Human	Functional	pEC50	=	7.9	7.9	60	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	260	2	0	2	3.9	c1ccc(-c2ccccc2[C@@H]2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.166
	2765	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(02)00753-9
	515	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(02)00753-9
	CHEMBL13852	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(02)00753-9
	DB09202	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(02)00753-9
	22493274	11042	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	258	4	2	4	2.1	c1ccc(N2CCCCC2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	CHEMBL117581	11042	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	258	4	2	4	2.1	c1ccc(N2CCCCC2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	10015132	163964	None	0	Human	Functional	pEC50	=	7.9	7.9	29	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	253	4	1	4	2.1	c1ccc(-c2ccccc2OCC2=NCCN2)nc1	10.1016/s0960-894x(02)00753-9
	CHEMBL420683	163964	None	0	Human	Functional	pEC50	=	7.9	7.9	29	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	253	4	1	4	2.1	c1ccc(-c2ccccc2OCC2=NCCN2)nc1	10.1016/s0960-894x(02)00753-9
	9817256	206696	None	0	Human	Functional	pEC50	=	7.9	7.9	251	2	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	CHEMBL71001	206696	None	0	Human	Functional	pEC50	=	7.9	7.9	251	2	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	2765	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00764-8
	515	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00764-8
	CHEMBL13852	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00764-8
	DB09202	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00764-8
	10038958	118789	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	273	4	1	5	2.5	Cc1cnsc1-c1ccccc1OCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	CHEMBL341747	118789	None	0	Human	Functional	pEC50	=	7.9	7.9	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	273	4	1	5	2.5	Cc1cnsc1-c1ccccc1OCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	10015132	163964	None	0	Human	Functional	pEC50	=	7.9	7.9	29	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	253	4	1	4	2.1	c1ccc(-c2ccccc2OCC2=NCCN2)nc1	10.1016/s0960-894x(01)00764-8
	CHEMBL420683	163964	None	0	Human	Functional	pEC50	=	7.9	7.9	29	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	253	4	1	4	2.1	c1ccc(-c2ccccc2OCC2=NCCN2)nc1	10.1016/s0960-894x(01)00764-8
	22493265	62154	None	0	Human	Functional	pEC50	=	7.9	7.9	19	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	284	6	2	6	1.8	CCCn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL17776	62154	None	0	Human	Functional	pEC50	=	7.9	7.9	19	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	284	6	2	6	1.8	CCCn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	2765	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00569-8
	515	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00569-8
	CHEMBL13852	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00569-8
	DB09202	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00569-8
	44329790	112609	None	0	Human	Functional	pEC50	=	7.9	7.9	5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	247	5	2	5	1.3	CCOC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL329928	112609	None	0	Human	Functional	pEC50	=	7.9	7.9	5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	247	5	2	5	1.3	CCOC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	22493224	210804	None	2	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	246	5	3	4	0.9	CCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL99362	210804	None	2	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	246	5	3	4	0.9	CCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	2765	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00822-8
	515	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00822-8
	CHEMBL13852	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00822-8
	DB09202	943	None	16	Human	Functional	pEC50	=	7.9	7.9	4	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	216	4	1	3	1.9	C1CN=C(N1)COc1ccccc1C1CC1	10.1016/s0960-894x(01)00822-8
	12924821	102952	None	4	Human	Functional	pEC50	=	6.9	6.9	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	207	2	1	3	1.5	COc1ccc(OC)c2c1CCC(N)C2	10.1021/jm00144a012
	CHEMBL30596	102952	None	4	Human	Functional	pEC50	=	6.9	6.9	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	207	2	1	3	1.5	COc1ccc(OC)c2c1CCC(N)C2	10.1021/jm00144a012
	44593577	178569	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.7	c1ccc(C2CCc3nc[nH]c3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL466296	178569	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.7	c1ccc(C2CCc3nc[nH]c3C2)cc1	10.1016/j.bmcl.2009.03.162
	44343251	10523	None	1	Human	Functional	pEC50	=	6.9	6.9	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	251	4	2	4	1.4	CS(=O)(=O)c1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	CHEMBL116843	10523	None	1	Human	Functional	pEC50	=	6.9	6.9	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	251	4	2	4	1.4	CS(=O)(=O)c1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	44362510	118997	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	267	4	1	4	2.4	Cc1cccc(-c2ccccc2OCC2=NCCN2)n1	10.1016/s0960-894x(01)00764-8
	CHEMBL342324	118997	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	267	4	1	4	2.4	Cc1cccc(-c2ccccc2OCC2=NCCN2)n1	10.1016/s0960-894x(01)00764-8
	22493257	210105	None	2	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	272	4	2	4	1.3	O=C(c1ccccc1NCC1=NCCN1)N1CCCC1	10.1016/s0960-894x(01)00569-8
	CHEMBL95245	210105	None	2	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	272	4	2	4	1.3	O=C(c1ccccc1NCC1=NCCN1)N1CCCC1	10.1016/s0960-894x(01)00569-8
	44362289	121762	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	254	4	1	5	1.5	c1cnc(-c2ccccc2OCC2=NCCN2)nc1	10.1016/s0960-894x(01)00764-8
	CHEMBL358802	121762	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	254	4	1	5	1.5	c1cnc(-c2ccccc2OCC2=NCCN2)nc1	10.1016/s0960-894x(01)00764-8
	44449306	95659	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	305	5	2	3	2.6	CCCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257801	95659	None	0	Human	Functional	pEC50	=	5.9	5.9	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	305	5	2	3	2.6	CCCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44449730	156199	None	0	Human	Functional	pEC50	=	7.9	7.9	22	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	2	2	2	2.9	c1cc(-c2cn[nH]c2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	CHEMBL406316	156199	None	0	Human	Functional	pEC50	=	7.9	7.9	22	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	2	2	2	2.9	c1cc(-c2cn[nH]c2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	9817256	206696	None	0	Human	Functional	pEC50	=	7.9	7.9	251	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	CHEMBL71001	206696	None	0	Human	Functional	pEC50	=	7.9	7.9	251	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	283	5	2	6	0.5	COc1ccc(S(C)(=O)=O)c(NCC2=NCCN2)c1	10.1021/jm000542r
	44449278	95705	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257977	95705	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44574877	178646	None	0	Human	Functional	pEC50	=	6.8	6.8	23	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	2	1	2	2.7	COc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL466869	178646	None	0	Human	Functional	pEC50	=	6.8	6.8	23	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	2	1	2	2.7	COc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	44574135	189287	None	1	Human	Functional	pEC50	=	7.8	7.8	18	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	1	3	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL511211	189287	None	1	Human	Functional	pEC50	=	7.8	7.8	18	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	1	3	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2ccn[nH]2)c1	10.1016/j.bmcl.2009.03.166
	22493269	46840	None	0	Human	Functional	pEC50	=	7.8	7.8	6	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1ncoc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL154023	46840	None	0	Human	Functional	pEC50	=	7.8	7.8	6	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1ncoc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	44343257	10503	None	0	Human	Functional	pEC50	=	7.8	7.8	13	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	250	4	1	2	3.7	c1ccc(-c2ccccc2OCc2c[nH]cn2)cc1	10.1016/s0960-894x(02)00753-9
	CHEMBL116700	10503	None	0	Human	Functional	pEC50	=	7.8	7.8	13	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	250	4	1	2	3.7	c1ccc(-c2ccccc2OCc2c[nH]cn2)cc1	10.1016/s0960-894x(02)00753-9
	10199052	210413	None	0	Human	Functional	pEC50	=	7.8	7.8	5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	258	5	3	4	1.0	O=C(NC1CC1)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL97044	210413	None	0	Human	Functional	pEC50	=	7.8	7.8	5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	258	5	3	4	1.0	O=C(NC1CC1)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	619552	102753	None	2	Rat	Functional	pEC50	=	5.8	5.8	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	250	2	0	3	2.5	Cn1nc(Cc2ccccc2)c2ccccc2c1=O	10.1016/j.bmcl.2006.02.003
	CHEMBL304747	102753	None	2	Rat	Functional	pEC50	=	5.8	5.8	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	250	2	0	3	2.5	Cn1nc(Cc2ccccc2)c2ccccc2c1=O	10.1016/j.bmcl.2006.02.003
	45280075	122429	None	0	Human	Functional	pEC50	=	5.8	5.8	-91	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	430	10	4	6	2.5	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C4CC4)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	CHEMBL3600395	122429	None	0	Human	Functional	pEC50	=	5.8	5.8	-91	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	430	10	4	6	2.5	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C4CC4)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	44343235	10199	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	241	4	1	4	2.6	c1ccc(-c2ccno2)c(OCc2c[nH]cn2)c1	10.1016/s0960-894x(02)00753-9
	CHEMBL115977	10199	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	241	4	1	4	2.6	c1ccc(-c2ccno2)c(OCc2c[nH]cn2)c1	10.1016/s0960-894x(02)00753-9
	44362013	35392	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	273	4	1	5	2.5	Cc1cc(-c2ccccc2OCC2=NCCN2)sn1	10.1016/s0960-894x(01)00764-8
	CHEMBL143766	35392	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	273	4	1	5	2.5	Cc1cc(-c2ccccc2OCC2=NCCN2)sn1	10.1016/s0960-894x(01)00764-8
	481	2892	None	6	Human	Functional	pEC50	=	6.8	6.8	8	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	248	4	3	4	0.2	NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O	10.1021/jm000542r
	9838763	2892	None	6	Human	Functional	pEC50	=	6.8	6.8	8	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	248	4	3	4	0.2	NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O	10.1021/jm000542r
	CHEMBL72958	2892	None	6	Human	Functional	pEC50	=	6.8	6.8	8	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	248	4	3	4	0.2	NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O	10.1021/jm000542r
	10199335	207205	None	0	Human	Functional	pEC50	=	7.8	7.8	120	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL74467	207205	None	0	Human	Functional	pEC50	=	7.8	7.8	120	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	44574834	172724	None	1	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	1	1	2.3	c1ccc2c(c1)CC(c1ncc[nH]1)C2	10.1016/j.bmcl.2009.03.162
	CHEMBL449279	172724	None	1	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	1	1	2.3	c1ccc2c(c1)CC(c1ncc[nH]1)C2	10.1016/j.bmcl.2009.03.162
	2146	3100	None	45	Rat	Functional	pEC50	=	5.8	5.8	-186	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	485	3100	None	45	Rat	Functional	pEC50	=	5.8	5.8	-186	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	6041	3100	None	45	Rat	Functional	pEC50	=	5.8	5.8	-186	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	6041.0	3100	None	45	Rat	Functional	pEC50	=	5.8	5.8	-186	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	CHEMBL1215	3100	None	45	Rat	Functional	pEC50	=	5.8	5.8	-186	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	DB00388	3100	None	45	Rat	Functional	pEC50	=	5.8	5.8	-186	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	44449247	95467	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	2	1	2	2.8	COc1c(C)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL256984	95467	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	2	1	2	2.8	COc1c(C)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44571843	179427	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	242	4	1	2	2.7	COCCc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL473425	179427	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	242	4	1	2	2.7	COCCc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	44571937	189659	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	282	3	1	3	2.9	Fc1ccn(Cc2cccc3c2CCC3c2ncc[nH]2)n1	10.1016/j.bmcl.2008.10.066
	CHEMBL514333	189659	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	282	3	1	3	2.9	Fc1ccn(Cc2cccc3c2CCC3c2ncc[nH]2)n1	10.1016/j.bmcl.2008.10.066
	9794803	11010	None	0	Human	Functional	pEC50	=	7.8	7.8	4	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2cnco2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	CHEMBL117381	11010	None	0	Human	Functional	pEC50	=	7.8	7.8	4	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2cnco2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	44449692	157077	None	0	Human	Functional	pEC50	=	6.8	6.8	8	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	251	2	1	3	3.1	c1cc(-c2ncco2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	CHEMBL407308	157077	None	0	Human	Functional	pEC50	=	6.8	6.8	8	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	251	2	1	3	3.1	c1cc(-c2ncco2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	44281493	100050	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	247	2	1	3	2.5	COc1ccc(OC)c2c1CC[C@H]1NCCCC21	10.1021/jm00144a012
	CHEMBL286702	100050	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	247	2	1	3	2.5	COc1ccc(OC)c2c1CC[C@H]1NCCCC21	10.1021/jm00144a012
	44574106	178531	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	317	3	1	3	3.3	CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL466012	178531	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	317	3	1	3	3.3	CNC(=O)c1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	44574107	188868	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	280	2	0	4	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2cncnc2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL505414	188868	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	280	2	0	4	2.8	Fc1ccc(C2Cc3nccn3C2)c(-c2cncnc2)c1	10.1016/j.bmcl.2009.03.166
	44574935	172725	None	0	Human	Functional	pEC50	=	7.7	7.7	19	3	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	218	1	0	2	2.9	Clc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL449284	172725	None	0	Human	Functional	pEC50	=	7.7	7.7	19	3	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	218	1	0	2	2.9	Clc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	9794803	11010	None	0	Human	Functional	pEC50	=	7.7	7.7	4	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	242	4	2	5	1.8	c1ccc(-c2cnco2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	CHEMBL117381	11010	None	0	Human	Functional	pEC50	=	7.7	7.7	4	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	242	4	2	5	1.8	c1ccc(-c2cnco2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	9859855	60417	None	0	Human	Functional	pEC50	=	7.7	7.7	12	2	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	254	4	2	4	2.1	Cn1cccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL17492	60417	None	0	Human	Functional	pEC50	=	7.7	7.7	12	2	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	254	4	2	4	2.1	Cn1cccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	124	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00569-8
	2032	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00569-8
	4636	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00569-8
	4636.0	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00569-8
	CHEMBL762	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00569-8
	DB00935	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00569-8
	22493320	4205	None	0	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	246	4	2	4	0.8	CN(C)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL100198	4205	None	0	Human	Functional	pEC50	=	7.7	7.7	3	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	246	4	2	4	0.8	CN(C)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44329481	4233	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	289	7	2	5	2.4	CCC(CC)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL100383	4233	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	289	7	2	5	2.4	CCC(CC)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	10378649	108649	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	7	3	4	1.6	CCCCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL320419	108649	None	0	Human	Functional	pEC50	=	7.7	7.7	15	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	7	3	4	1.6	CCCCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	124	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00822-8
	2032	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00822-8
	4636	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00822-8
	4636.0	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00822-8
	CHEMBL762	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00822-8
	DB00935	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1016/s0960-894x(01)00822-8
	11811395	207159	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	281	5	2	5	1.3	CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL74071	207159	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	281	5	2	5	1.3	CC(C)S(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	44571844	172658	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	295	4	2	2	3.1	FC(F)(F)CNCc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL448510	172658	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	295	4	2	2	3.1	FC(F)(F)CNCc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	22493367	66206	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	298	7	2	6	2.2	CCCCn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL18436	66206	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	298	7	2	6	2.2	CCCCn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	44574075	172679	None	0	Human	Functional	pEC50	=	8.7	8.7	72	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	251	2	0	4	2.9	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL448802	172679	None	0	Human	Functional	pEC50	=	8.7	8.7	72	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	251	2	0	4	2.9	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
	44369351	119666	None	0	Human	Functional	pEC50	=	8.7	8.7	2	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	257	4	2	4	2.8	c1csc(-c2ccccc2NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	CHEMBL346380	119666	None	0	Human	Functional	pEC50	=	8.7	8.7	2	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	257	4	2	4	2.8	c1csc(-c2ccccc2NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	11140347	206991	None	1	Human	Functional	pEC50	=	8.6	8.6	-1	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL72768	206991	None	1	Human	Functional	pEC50	=	8.6	8.6	-1	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	239	4	2	4	2.0	CSc1ccc(F)cc1NCC1=NCCN1	10.1021/jm000542r
	44362196	34497	None	0	Human	Functional	pEC50	=	8.6	8.6	7	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	259	4	1	5	2.2	c1ccc(-c2nccs2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL142871	34497	None	0	Human	Functional	pEC50	=	8.6	8.6	7	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	259	4	1	5	2.2	c1ccc(-c2nccs2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	44362288	35638	None	0	Human	Functional	pEC50	=	8.6	8.6	251	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	254	4	1	5	1.5	c1ccc(-c2cnccn2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL143973	35638	None	0	Human	Functional	pEC50	=	8.6	8.6	251	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	254	4	1	5	1.5	c1ccc(-c2cnccn2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	9881853	98527	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	268	5	2	4	2.6	CCn1cccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL275902	98527	None	0	Human	Functional	pEC50	=	8.6	8.6	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	268	5	2	4	2.6	CCn1cccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	10198532	210155	None	0	Human	Functional	pEC50	=	8.6	8.6	1	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	232	4	3	4	0.5	CNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL95523	210155	None	0	Human	Functional	pEC50	=	8.6	8.6	1	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	232	4	3	4	0.5	CNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44369434	45395	None	0	Human	Functional	pEC50	=	8.6	8.6	17	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	255	4	2	4	2.7	Cc1ccc(-c2ccccc2NCC2=NCCN2)o1	10.1016/s0960-894x(01)00822-8
	CHEMBL152725	45395	None	0	Human	Functional	pEC50	=	8.6	8.6	17	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	255	4	2	4	2.7	Cc1ccc(-c2ccccc2NCC2=NCCN2)o1	10.1016/s0960-894x(01)00822-8
	9947861	206620	None	0	Human	Functional	pEC50	=	8.6	8.6	21	3	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70634	206620	None	0	Human	Functional	pEC50	=	8.6	8.6	21	3	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1ccc(Cl)cc1NCC1=NCCN1	10.1021/jm000542r
	124	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	2032	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	4636	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	4636.0	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	CHEMBL762	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	DB00935	2981	None	32	Human	Functional	pEC50	=	7.7	7.7	-8	24	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm000542r
	10422033	121039	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	246	5	2	5	1.5	CO/N=C(\C)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL356195	121039	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	246	5	2	5	1.5	CO/N=C(\C)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	44281250	114870	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	247	2	1	3	2.5	COc1ccc(OC)c2c1CC[C@@H]1NCCCC21	10.1021/jm00144a012
	CHEMBL33405	114870	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	247	2	1	3	2.5	COc1ccc(OC)c2c1CC[C@@H]1NCCCC21	10.1021/jm00144a012
	44449691	96215	None	0	Human	Functional	pEC50	=	5.7	5.7	2	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	1	2	3.6	c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1	10.1016/j.bmcl.2008.03.070
	CHEMBL260576	96215	None	0	Human	Functional	pEC50	=	5.7	5.7	2	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	1	2	3.6	c1cncc(-c2cccc3c2CCC3c2ncc[nH]2)c1	10.1016/j.bmcl.2008.03.070
	4038180	204	None	12	Human	Functional	pEC50	=	7.7	7.7	-1	6	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm960354u
	480	204	None	12	Human	Functional	pEC50	=	7.7	7.7	-1	6	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm960354u
	CHEMBL109783	204	None	12	Human	Functional	pEC50	=	7.7	7.7	-1	6	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm960354u
	44449278	95705	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257977	95705	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	1960	2857	None	46	Human	Functional	pEC50	=	5.7	5.7	-2	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	439260	2857	None	46	Human	Functional	pEC50	=	5.7	5.7	-2	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	439260.0	2857	None	46	Human	Functional	pEC50	=	5.7	5.7	-2	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	505	2857	None	46	Human	Functional	pEC50	=	5.7	5.7	-2	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	CHEMBL1437	2857	None	46	Human	Functional	pEC50	=	5.7	5.7	-2	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	DB00368	2857	None	46	Human	Functional	pEC50	=	5.7	5.7	-2	18	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm960354u
	10135864	122584	None	0	Human	Functional	pEC50	=	6.7	6.7	-10	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	404	9	4	6	1.9	Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	CHEMBL3601200	122584	None	0	Human	Functional	pEC50	=	6.7	6.7	-10	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	404	9	4	6	1.9	Cc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	44574937	178766	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	0	3	2.2	COc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL467688	178766	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	0	3	2.2	COc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	44449276	95704	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	241	2	2	2	1.8	CNC(=O)c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257976	95704	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	241	2	2	2	1.8	CNC(=O)c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	11090351	163486	None	0	Human	Functional	pEC50	=	7.6	7.6	20	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL419448	163486	None	0	Human	Functional	pEC50	=	7.6	7.6	20	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	44449278	95705	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257977	95705	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	CS(=O)(=O)Nc1cccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44593577	178569	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.7	c1ccc(C2CCc3nc[nH]c3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL466296	178569	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.7	c1ccc(C2CCc3nc[nH]c3C2)cc1	10.1016/j.bmcl.2009.03.162
	10221004	206689	None	0	Human	Functional	pEC50	=	6.6	6.6	20	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	267	5	2	5	0.9	CCS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70973	206689	None	0	Human	Functional	pEC50	=	6.6	6.6	20	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	267	5	2	5	0.9	CCS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	22493356	47025	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	266	4	2	4	2.5	Cc1cccnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL154170	47025	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	266	4	2	4	2.5	Cc1cccnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	10804826	23623	None	1	Human	Functional	pEC50	=	4.6	4.6	1	2	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1	10.1021/jm960354u
	CHEMBL133451	23623	None	1	Human	Functional	pEC50	=	4.6	4.6	1	2	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1	10.1021/jm960354u
	216249	1305	None	38	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	317	5	2	5	1.4	Clc1ccc(c(c1NS(=O)(=O)C)C)OCC1=NCCN1	10.1016/j.bmcl.2008.03.070
	3469	1305	None	38	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	317	5	2	5	1.4	Clc1ccc(c(c1NS(=O)(=O)C)C)OCC1=NCCN1	10.1016/j.bmcl.2008.03.070
	CHEMBL257978	1305	None	38	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	317	5	2	5	1.4	Clc1ccc(c(c1NS(=O)(=O)C)C)OCC1=NCCN1	10.1016/j.bmcl.2008.03.070
	10423384	34605	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	272	4	1	4	3.1	Cc1ccc(-c2ccccc2OCC2=NCCN2)s1	10.1016/s0960-894x(01)00764-8
	CHEMBL142958	34605	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	272	4	1	4	3.1	Cc1ccc(-c2ccccc2OCC2=NCCN2)s1	10.1016/s0960-894x(01)00764-8
	10084685	119500	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	273	4	1	5	2.5	Cc1csc(-c2ccccc2OCC2=NCCN2)n1	10.1016/s0960-894x(01)00764-8
	CHEMBL344957	119500	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	273	4	1	5	2.5	Cc1csc(-c2ccccc2OCC2=NCCN2)n1	10.1016/s0960-894x(01)00764-8
	10221066	163257	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	269	5	2	5	2.0	CCn1ccc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(03)00050-7
	CHEMBL417999	163257	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	269	5	2	5	2.0	CCn1ccc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(03)00050-7
	44271931	98446	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	283	6	2	5	2.4	CCCn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL275386	98446	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	283	6	2	5	2.4	CCCn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	10180440	122585	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	420	10	4	7	1.6	COc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	CHEMBL3601201	122585	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	420	10	4	7	1.6	COc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	2683	3834	None	40	Bovine	Functional	pEC50	=	6.6	6.6	1	6	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	5487	3834	None	40	Bovine	Functional	pEC50	=	6.6	6.6	1	6	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	5487.0	3834	None	40	Bovine	Functional	pEC50	=	6.6	6.6	1	6	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	7308	3834	None	40	Bovine	Functional	pEC50	=	6.6	6.6	1	6	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	CHEMBL1079	3834	None	40	Bovine	Functional	pEC50	=	6.6	6.6	1	6	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	DB00697	3834	None	40	Bovine	Functional	pEC50	=	6.6	6.6	1	6	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	253	1	2	6	1.7	Clc1ccc2c(c1NC1=NCCN1)nsn2	nan
	44574138	178610	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	0	4	2.5	Fc1ccc(C2Cc3nccn3C2)c(-n2cccn2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL466635	178610	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	0	4	2.5	Fc1ccc(C2Cc3nccn3C2)c(-n2cccn2)c1	10.1016/j.bmcl.2009.03.166
	44593557	184024	None	12	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	262	3	1	2	3.3	COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2009.03.162
	CHEMBL481322	184024	None	12	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	262	3	1	2	3.3	COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2009.03.162
	44574874	178498	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	232	1	1	1	3.3	Clc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL465599	178498	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	232	1	1	1	3.3	Clc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	122184771	122586	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	434	11	4	7	2.0	CCOc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	CHEMBL3601202	122586	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	434	11	4	7	2.0	CCOc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	44449723	156225	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	264	2	1	3	2.9	Cn1nccc1-c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL406348	156225	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	264	2	1	3	2.9	Cn1nccc1-c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	124	2981	None	32	Rat	Functional	pEC50	=	6.5	6.5	-52	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	2032	2981	None	32	Rat	Functional	pEC50	=	6.5	6.5	-52	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	4636	2981	None	32	Rat	Functional	pEC50	=	6.5	6.5	-52	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	4636.0	2981	None	32	Rat	Functional	pEC50	=	6.5	6.5	-52	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	CHEMBL762	2981	None	32	Rat	Functional	pEC50	=	6.5	6.5	-52	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	DB00935	2981	None	32	Rat	Functional	pEC50	=	6.5	6.5	-52	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	2146	3100	None	45	Human	Functional	pEC50	=	5.5	5.5	-20	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	485	3100	None	45	Human	Functional	pEC50	=	5.5	5.5	-20	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	6041	3100	None	45	Human	Functional	pEC50	=	5.5	5.5	-20	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	6041.0	3100	None	45	Human	Functional	pEC50	=	5.5	5.5	-20	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	CHEMBL1215	3100	None	45	Human	Functional	pEC50	=	5.5	5.5	-20	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	DB00388	3100	None	45	Human	Functional	pEC50	=	5.5	5.5	-20	14	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1021/jm960354u
	44574134	178609	None	0	Human	Functional	pEC50	=	8.5	8.5	91	3	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	269	2	0	4	3.0	Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL466634	178609	None	0	Human	Functional	pEC50	=	8.5	8.5	91	3	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	269	2	0	4	3.0	Fc1ccc(-c2ncco2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	44574077	178865	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	267	2	0	4	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL468710	178865	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	267	2	0	4	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2nccs2)c1	10.1016/j.bmcl.2009.03.166
	44574136	189149	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	1	3	2.8	Fc1ccc(-c2ccn[nH]2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL509350	189149	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	1	3	2.8	Fc1ccc(-c2ccn[nH]2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	44449725	96243	None	0	Human	Functional	pEC50	=	8.5	8.5	208	3	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	264	2	2	2	3.2	Cc1n[nH]cc1-c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL260720	96243	None	0	Human	Functional	pEC50	=	8.5	8.5	208	3	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	264	2	2	2	3.2	Cc1n[nH]cc1-c1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44269124	28826	None	0	Human	Functional	pEC50	=	8.5	8.5	23	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	252	4	1	3	2.7	c1ccc(-c2ccccc2OCC2=NCCN2)cc1	10.1016/s0960-894x(02)00753-9
	CHEMBL13789	28826	None	0	Human	Functional	pEC50	=	8.5	8.5	23	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	252	4	1	3	2.7	c1ccc(-c2ccccc2OCC2=NCCN2)cc1	10.1016/s0960-894x(02)00753-9
	44269124	28826	None	0	Human	Functional	pEC50	=	8.5	8.5	23	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	252	4	1	3	2.7	c1ccc(-c2ccccc2OCC2=NCCN2)cc1	10.1016/s0960-894x(01)00764-8
	CHEMBL13789	28826	None	0	Human	Functional	pEC50	=	8.5	8.5	23	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	252	4	1	3	2.7	c1ccc(-c2ccccc2OCC2=NCCN2)cc1	10.1016/s0960-894x(01)00764-8
	10060965	35243	None	0	Human	Functional	pEC50	=	8.5	8.5	39	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	256	4	1	4	2.6	Cc1ccoc1-c1ccccc1OCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	CHEMBL143562	35243	None	0	Human	Functional	pEC50	=	8.5	8.5	39	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	256	4	1	4	2.6	Cc1ccoc1-c1ccccc1OCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	9816515	62998	None	0	Human	Functional	pEC50	=	8.5	8.5	5	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1ccc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(03)00050-7
	CHEMBL17856	62998	None	0	Human	Functional	pEC50	=	8.5	8.5	5	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1ccc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(03)00050-7
	44329797	108162	None	0	Human	Functional	pEC50	=	8.5	8.5	67	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	261	5	2	5	1.7	CC(C)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL319553	108162	None	0	Human	Functional	pEC50	=	8.5	8.5	67	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	261	5	2	5	1.7	CC(C)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	10244367	50057	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	6	2	5	1.9	CC/C(=N\OC)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL156950	50057	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	6	2	5	1.9	CC/C(=N\OC)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	11000184	13057	None	0	Human	Functional	pEC50	=	8.5	8.5	4	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL1190038	13057	None	0	Human	Functional	pEC50	=	8.5	8.5	4	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL540035	13057	None	0	Human	Functional	pEC50	=	8.5	8.5	4	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	235	5	2	4	2.2	CCSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	44343247	110698	None	0	Human	Functional	pEC50	=	8.4	8.4	15	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	258	6	3	3	2.2	CCCNC(=O)c1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	CHEMBL325745	110698	None	0	Human	Functional	pEC50	=	8.4	8.4	15	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	258	6	3	3	2.2	CCCNC(=O)c1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	15959112	205990	None	0	Rat	Functional	pEC50	=	5.5	5.5	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	280	2	1	5	2.7	Oc1nnc(Cc2ccc3c(c2)OCO3)c2ccccc12	10.1016/j.bmcl.2006.02.003
	CHEMBL66433	205990	None	0	Rat	Functional	pEC50	=	5.5	5.5	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	280	2	1	5	2.7	Oc1nnc(Cc2ccc3c(c2)OCO3)c2ccccc12	10.1016/j.bmcl.2006.02.003
	11264016	99700	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	193	2	1	3	1.1	COc1ccc(OC)c2c1CC(N)C2	10.1021/jm00144a012
	CHEMBL284307	99700	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	193	2	1	3	1.1	COc1ccc(OC)c2c1CC(N)C2	10.1021/jm00144a012
	44281507	99981	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	233	2	1	3	2.4	COc1ccc(OC)c2c1C1CCC2[C@@H](N)C1	10.1021/jm00144a012
	CHEMBL286226	99981	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	233	2	1	3	2.4	COc1ccc(OC)c2c1C1CCC2[C@@H](N)C1	10.1021/jm00144a012
	44280965	100037	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	233	2	1	3	2.4	COc1ccc(OC)c2c1C1CCC2[C@H](N)C1	10.1021/jm00144a012
	CHEMBL286609	100037	None	0	Human	Functional	pEC50	=	4.5	4.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	233	2	1	3	2.4	COc1ccc(OC)c2c1C1CCC2[C@H](N)C1	10.1021/jm00144a012
	10804826	23623	None	1	Rat	Functional	pEC50	=	4.5	4.5	-1	2	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1	10.1021/jm960354u
	CHEMBL133451	23623	None	1	Rat	Functional	pEC50	=	4.5	4.5	-1	2	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@@H]2C1=NCCN1	10.1021/jm960354u
	44593557	184024	None	12	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	262	3	1	2	3.3	COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2009.03.166
	CHEMBL481322	184024	None	12	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	262	3	1	2	3.3	COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2009.03.166
	44593557	184024	None	12	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	262	3	1	2	3.3	COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL481322	184024	None	12	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	262	3	1	2	3.3	COCc1c(Cl)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	9816986	164234	None	0	Human	Functional	pEC50	=	7.5	7.5	21	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	274	6	2	4	1.6	CCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	CHEMBL421011	164234	None	0	Human	Functional	pEC50	=	7.5	7.5	21	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	274	6	2	4	1.6	CCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	9816986	164234	None	0	Human	Functional	pEC50	=	7.5	7.5	21	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	274	6	2	4	1.6	CCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	CHEMBL421011	164234	None	0	Human	Functional	pEC50	=	7.5	7.5	21	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	274	6	2	4	1.6	CCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	9816986	164234	None	0	Human	Functional	pEC50	=	7.5	7.5	21	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	6	2	4	1.6	CCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL421011	164234	None	0	Human	Functional	pEC50	=	7.5	7.5	21	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	6	2	4	1.6	CCN(CC)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44593577	178569	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.7	c1ccc(C2CCc3nc[nH]c3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL466296	178569	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.7	c1ccc(C2CCc3nc[nH]c3C2)cc1	10.1016/j.bmcl.2009.03.162
	481	2892	None	6	Human	Functional	pEC50	=	6.5	6.5	8	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	248	4	3	4	0.2	NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O	10.1016/s0960-894x(01)00764-8
	9838763	2892	None	6	Human	Functional	pEC50	=	6.5	6.5	8	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	248	4	3	4	0.2	NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O	10.1016/s0960-894x(01)00764-8
	CHEMBL72958	2892	None	6	Human	Functional	pEC50	=	6.5	6.5	8	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	248	4	3	4	0.2	NC[C@@H](c1cc(ccc1F)NS(=O)(=O)C)O	10.1016/s0960-894x(01)00764-8
	22493344	98715	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	323	5	2	5	2.5	FC(F)(F)Cn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL277361	98715	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	323	5	2	5	2.5	FC(F)(F)Cn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	44449277	155273	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	1	2	2.5	COc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL402388	155273	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	1	2	2.5	COc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44449305	155700	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	4	2	3	2.2	CCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL404566	155700	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	4	2	3	2.2	CCS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44571889	184135	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	264	3	1	3	2.7	c1cc(Cn2cccn2)c2c(c1)[C@H](c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.10.066
	CHEMBL482148	184135	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	264	3	1	3	2.7	c1cc(Cn2cccn2)c2c(c1)[C@H](c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.10.066
	44449337	155206	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	284	2	2	2	3.5	Clc1ccc2c(c1-c1ccn[nH]1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL402003	155206	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	284	2	2	2	3.5	Clc1ccc2c(c1-c1ccn[nH]1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	22493272	44769	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1nc(-c2ccccc2NCC2=NCCN2)co1	10.1016/s0960-894x(01)00822-8
	CHEMBL152154	44769	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1nc(-c2ccccc2NCC2=NCCN2)co1	10.1016/s0960-894x(01)00822-8
	44574133	188483	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	269	2	0	4	3.0	Fc1ccc(C2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL501404	188483	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	269	2	0	4	3.0	Fc1ccc(C2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
	122184835	122607	None	0	Human	Functional	pEC50	=	7.5	7.5	3	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	420	10	5	7	1.1	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(CO)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	CHEMBL3601310	122607	None	0	Human	Functional	pEC50	=	7.5	7.5	3	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	420	10	5	7	1.1	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(CO)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	44449249	95251	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	Cc1ccc2c(c1NS(C)(=O)=O)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL255938	95251	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	291	3	2	3	2.2	Cc1ccc2c(c1NS(C)(=O)=O)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	10420352	168843	None	6	Human	Functional	pEC50	=	5.5	5.5	-83	2	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	201	3	4	4	0.5	CNCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	CHEMBL43711	168843	None	6	Human	Functional	pEC50	=	5.5	5.5	-83	2	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	201	3	4	4	0.5	CNCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	44280982	99818	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	205	2	1	3	1.3	COc1ccc(OC)c2c1CC1C2[C@@H]1N	10.1021/jm00144a012
	CHEMBL285082	99818	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	205	2	1	3	1.3	COc1ccc(OC)c2c1CC1C2[C@@H]1N	10.1021/jm00144a012
	124	2981	None	32	Human	Functional	pEC50	=	6.5	6.5	-8	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	2032	2981	None	32	Human	Functional	pEC50	=	6.5	6.5	-8	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	4636	2981	None	32	Human	Functional	pEC50	=	6.5	6.5	-8	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	4636.0	2981	None	32	Human	Functional	pEC50	=	6.5	6.5	-8	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	CHEMBL762	2981	None	32	Human	Functional	pEC50	=	6.5	6.5	-8	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	DB00935	2981	None	32	Human	Functional	pEC50	=	6.5	6.5	-8	24	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1021/jm960354u
	44574936	178735	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	218	1	0	2	2.9	Clc1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL467495	178735	None	0	Human	Functional	pEC50	=	5.5	5.5	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	218	1	0	2	2.9	Clc1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	44369646	120227	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	271	4	2	4	3.1	Cc1ccc(-c2ccccc2NCC2=NCCN2)s1	10.1016/s0960-894x(01)00822-8
	CHEMBL351543	120227	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	271	4	2	4	3.1	Cc1ccc(-c2ccccc2NCC2=NCCN2)s1	10.1016/s0960-894x(01)00822-8
	44571841	179426	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	228	3	1	2	2.6	COCc1cccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL473424	179426	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	228	3	1	2	2.6	COCc1cccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	44574988	189338	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	227	2	1	3	1.3	NC(=O)c1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL511576	189338	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	227	2	1	3	1.3	NC(=O)c1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	521	1404	None	49	Bovine	Functional	pEC50	=	6.4	6.4	-501	5	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	5311068	1404	None	49	Bovine	Functional	pEC50	=	6.4	6.4	-501	5	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	5311068.0	1404	None	49	Bovine	Functional	pEC50	=	6.4	6.4	-501	5	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	835	1404	None	49	Bovine	Functional	pEC50	=	6.4	6.4	-501	5	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	CHEMBL778	1404	None	49	Bovine	Functional	pEC50	=	6.4	6.4	-501	5	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	DB00633	1404	None	49	Bovine	Functional	pEC50	=	6.4	6.4	-501	5	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	200	2	1	1	3.2	Cc1cccc(c1C)[C@@H](c1c[nH]cn1)C	nan
	22493349	119751	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1cc(-c2ccccc2NCC2=NCCN2)on1	10.1016/s0960-894x(01)00822-8
	CHEMBL347268	119751	None	0	Human	Functional	pEC50	=	7.4	7.4	2	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	256	4	2	5	2.1	Cc1cc(-c2ccccc2NCC2=NCCN2)on1	10.1016/s0960-894x(01)00822-8
	17804479	95713	None	18	Human	Functional	pEC50	=	6.4	6.4	-1	4	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.9	c1ccc2c(c1)CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL258007	95713	None	18	Human	Functional	pEC50	=	6.4	6.4	-1	4	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	1	1	2.9	c1ccc2c(c1)CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	10083742	34615	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	256	4	1	5	1.5	Cn1nccc1-c1ccccc1OCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	CHEMBL142967	34615	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	256	4	1	5	1.5	Cn1nccc1-c1ccccc1OCC1=NCCN1	10.1016/s0960-894x(01)00764-8
	44329739	112387	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	287	5	2	5	2.2	O=C(OC1CCCC1)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL329272	112387	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	287	5	2	5	2.2	O=C(OC1CCCC1)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	104452	205559	None	47	Rat	Functional	pEC50	=	5.4	5.4	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	270	2	1	3	3.6	Oc1nnc(Cc2ccc(Cl)cc2)c2ccccc12	10.1016/j.bmcl.2006.02.003
	CHEMBL63976	205559	None	47	Rat	Functional	pEC50	=	5.4	5.4	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	270	2	1	3	3.6	Oc1nnc(Cc2ccc(Cl)cc2)c2ccccc12	10.1016/j.bmcl.2006.02.003
	22493381	98135	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1cc(-c2ccccc2NCC2=NCCN2)cn1	10.1016/s0960-894x(03)00050-7
	CHEMBL273312	98135	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1cc(-c2ccccc2NCC2=NCCN2)cn1	10.1016/s0960-894x(03)00050-7
	22493231	210124	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	286	4	2	4	1.7	O=C(c1ccccc1NCC1=NCCN1)N1CCCCC1	10.1016/s0960-894x(01)00569-8
	CHEMBL95333	210124	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	286	4	2	4	1.7	O=C(c1ccccc1NCC1=NCCN1)N1CCCCC1	10.1016/s0960-894x(01)00569-8
	44574104	189598	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	353	4	1	4	3.3	CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL513871	189598	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	353	4	1	4	3.3	CS(=O)(=O)Nc1cccc(-c2ccccc2[C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	9838376	168403	None	0	Human	Functional	pEC50	=	8.4	8.4	15	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	272	4	2	5	2.5	Cc1nc(-c2ccccc2NCC2=NCCN2)cs1	10.1016/s0960-894x(01)00822-8
	CHEMBL434074	168403	None	0	Human	Functional	pEC50	=	8.4	8.4	15	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	272	4	2	5	2.5	Cc1nc(-c2ccccc2NCC2=NCCN2)cs1	10.1016/s0960-894x(01)00822-8
	11108001	10876	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	5	Agonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL117248	10876	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	5	Agonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL540542	10876	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	5	Agonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1A adrenoceptors assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	9816460	119957	None	0	Human	Functional	pEC50	=	8.3	8.3	39	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	253	4	2	5	1.6	c1ccc(-c2cnccn2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	CHEMBL349082	119957	None	0	Human	Functional	pEC50	=	8.3	8.3	39	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	253	4	2	5	1.6	c1ccc(-c2cnccn2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	1028	291	None	40	Human	Functional	pEC50	=	6.4	6.4	1	19	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	139148732	291	None	40	Human	Functional	pEC50	=	6.4	6.4	1	19	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	479	291	None	40	Human	Functional	pEC50	=	6.4	6.4	1	19	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	5816	291	None	40	Human	Functional	pEC50	=	6.4	6.4	1	19	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	5816.0	291	None	40	Human	Functional	pEC50	=	6.4	6.4	1	19	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	CHEMBL679	291	None	40	Human	Functional	pEC50	=	6.4	6.4	1	19	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	DB00668	291	None	40	Human	Functional	pEC50	=	6.4	6.4	1	19	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm00118a019
	11058166	207163	None	0	Human	Functional	pEC50	=	7.4	7.4	10	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL74114	207163	None	0	Human	Functional	pEC50	=	7.4	7.4	10	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cccc(F)c1NCC1=NCCN1	10.1021/jm000542r
	44574986	189319	None	0	Human	Functional	pEC50	=	7.4	7.4	7	3	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	202	1	0	2	2.4	Fc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL511411	189319	None	0	Human	Functional	pEC50	=	7.4	7.4	7	3	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	202	1	0	2	2.4	Fc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	22493415	49987	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	268	4	3	6	1.1	Nc1nccc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(01)00822-8
	CHEMBL156893	49987	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	268	4	3	6	1.1	Nc1nccc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(01)00822-8
	44449686	96137	None	0	Human	Functional	pEC50	=	6.4	6.4	7	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	267	2	1	3	3.6	c1cc(-c2nccs2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	CHEMBL260116	96137	None	0	Human	Functional	pEC50	=	6.4	6.4	7	2	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	267	2	1	3	3.6	c1cc(-c2nccs2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	25066019	95465	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	325	3	2	3	2.9	CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL256982	95465	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	325	3	2	3	2.9	CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	25066019	95465	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	325	3	2	3	2.9	CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2009.03.162
	CHEMBL256982	95465	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	325	3	2	3	2.9	CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2009.03.162
	25066019	95465	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	325	3	2	3	2.9	CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL256982	95465	None	0	Human	Functional	pEC50	=	7.4	7.4	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	325	3	2	3	2.9	CS(=O)(=O)Nc1c(Cl)ccc2c1CCCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	11079593	206573	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70326	206573	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	271	4	2	5	0.6	CS(=O)(=O)c1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	15959119	77084	None	0	Rat	Functional	pEC50	=	5.4	5.4	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	310	4	0	3	3.8	C=CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2006.02.003
	CHEMBL207277	77084	None	0	Rat	Functional	pEC50	=	5.4	5.4	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	310	4	0	3	3.8	C=CCn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2006.02.003
	44369647	47221	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2cnoc2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	CHEMBL154346	47221	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	242	4	2	5	1.8	c1ccc(-c2cnoc2)c(NCC2=NCCN2)c1	10.1016/s0960-894x(01)00822-8
	44449248	95250	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	248	2	1	2	3.2	COc1c(Cl)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL255937	95250	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	248	2	1	2	3.2	COc1c(Cl)ccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44449338	95744	None	1	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	1	1	2.5	c1ccc2c(c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL258178	95744	None	1	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	1	1	2.5	c1ccc2c(c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44449338	95744	None	1	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	1	1	2.5	c1ccc2c(c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2009.03.162
	CHEMBL258178	95744	None	1	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	1	1	2.5	c1ccc2c(c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2009.03.162
	44593580	178647	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	242	3	1	2	2.8	COCc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL466876	178647	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	242	3	1	2	2.8	COCc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	11747739	13240	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL1191324	13240	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL542402	13240	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	237	4	2	4	0.8	C[S+]([O-])c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	44574103	172691	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	2	0	4	2.4	c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL448908	172691	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	2	0	4	2.4	c1ccc(-n2cccn2)c([C@@H]2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	44574137	189199	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	0	4	2.5	Fc1ccc(-n2cccn2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL510023	189199	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	268	2	0	4	2.5	Fc1ccc(-n2cccn2)c(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.166
	11108001	10876	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	5	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	CHEMBL117248	10876	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	5	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	CHEMBL540542	10876	None	0	Human	Functional	pEC50	=	8.3	8.3	-2	5	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	221	4	2	4	1.8	CSc1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	44362149	33940	None	0	Human	Functional	pEC50	=	8.3	8.3	2	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	259	4	1	5	2.2	c1ccc(-c2ccns2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL142387	33940	None	0	Human	Functional	pEC50	=	8.3	8.3	2	3	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	259	4	1	5	2.2	c1ccc(-c2ccns2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	44362150	119454	None	0	Human	Functional	pEC50	=	8.3	8.3	15	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	2	4	1.5	c1ccc(-c2cc[nH]n2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	CHEMBL344551	119454	None	0	Human	Functional	pEC50	=	8.3	8.3	15	2	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	242	4	2	4	1.5	c1ccc(-c2cc[nH]n2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(01)00764-8
	10859076	13687	None	0	Human	Functional	pEC50	=	8.3	8.3	5	4	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL1194763	13687	None	0	Human	Functional	pEC50	=	8.3	8.3	5	4	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL553276	13687	None	0	Human	Functional	pEC50	=	8.3	8.3	5	4	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	249	5	2	4	2.6	CC(C)Sc1ccccc1NCC1=NCCN1	10.1021/jm000542r
	6604803	116582	None	0	Rat	Functional	pEC50	=	8.3	8.3	1	3	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1	10.1021/jm960354u
	CHEMBL336161	116582	None	0	Rat	Functional	pEC50	=	8.3	8.3	1	3	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1	10.1021/jm960354u
	6604803	116582	None	0	Human	Functional	pEC50	=	8.3	8.3	-1	3	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1	10.1021/jm960354u
	CHEMBL336161	116582	None	0	Human	Functional	pEC50	=	8.3	8.3	-1	3	In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostateIn vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate	ChEMBL	309	3	3	5	1.2	CS(=O)(=O)Nc1c(O)ccc2c1CCC[C@H]2C1=NCCN1	10.1021/jm960354u
	4038180	204	None	12	Rat	Functional	pEC50	=	8.2	8.2	1	6	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm960354u
	480	204	None	12	Rat	Functional	pEC50	=	8.2	8.2	1	6	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm960354u
	CHEMBL109783	204	None	12	Rat	Functional	pEC50	=	8.2	8.2	1	6	In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensIn vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	309	3	3	5	1.2	Oc1ccc2c(c1NS(=O)(=O)C)CCCC2C1=NCCN1	10.1021/jm960354u
	9816461	10723	None	4	Human	Functional	pEC50	=	7.3	7.3	60	2	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	CHEMBL117094	10723	None	4	Human	Functional	pEC50	=	7.3	7.3	60	2	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	CHEMBL544290	10723	None	4	Human	Functional	pEC50	=	7.3	7.3	60	2	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	44343245	110678	None	1	Human	Functional	pEC50	=	7.3	7.3	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	256	4	2	3	3.0	c1ccc(N2CCCCC2)c(NCc2c[nH]cn2)c1	10.1016/s0960-894x(02)00753-9
	CHEMBL325648	110678	None	1	Human	Functional	pEC50	=	7.3	7.3	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	256	4	2	3	3.0	c1ccc(N2CCCCC2)c(NCc2c[nH]cn2)c1	10.1016/s0960-894x(02)00753-9
	44343275	110837	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	240	4	2	4	2.7	c1ccc(-c2cnco2)c(NCc2c[nH]cn2)c1	10.1016/s0960-894x(02)00753-9
	CHEMBL326067	110837	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	240	4	2	4	2.7	c1ccc(-c2cnco2)c(NCc2c[nH]cn2)c1	10.1016/s0960-894x(02)00753-9
	22493233	169390	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	268	4	2	4	2.4	Cc1ccc(-c2ccccc2NCC2=NCCN2)n1C	10.1016/s0960-894x(03)00050-7
	CHEMBL441412	169390	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	268	4	2	4	2.4	Cc1ccc(-c2ccccc2NCC2=NCCN2)n1C	10.1016/s0960-894x(03)00050-7
	9903313	172781	None	0	Human	Functional	pEC50	=	7.3	7.3	5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	5	2	4	1.2	CCN(C)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL450018	172781	None	0	Human	Functional	pEC50	=	7.3	7.3	5	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	5	2	4	1.2	CCN(C)C(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	22493379	210585	None	0	Human	Functional	pEC50	=	7.3	7.3	2	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	5	3	4	1.2	CC(C)NC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL98016	210585	None	0	Human	Functional	pEC50	=	7.3	7.3	2	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	5	3	4	1.2	CC(C)NC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	22493411	168133	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	6	3	4	1.6	CCC(C)NC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL432192	168133	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	6	3	4	1.6	CCC(C)NC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44329701	210137	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	6	2	5	1.9	CC(C)COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL95398	210137	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	6	2	5	1.9	CC(C)COC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44574044	178536	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	209	1	0	3	2.1	N#Cc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
	CHEMBL466046	178536	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	209	1	0	3	2.1	N#Cc1ccccc1[C@@H]1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
	44219719	178783	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	209	1	0	3	2.1	N#Cc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL467916	178783	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	209	1	0	3	2.1	N#Cc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	10399043	120226	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	232	5	2	5	1.1	CO/N=C/c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL351542	120226	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	232	5	2	5	1.1	CO/N=C/c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	10916464	206611	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70563	206611	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	287	4	2	5	1.2	CS(=O)(=O)c1cc(Cl)ccc1NCC1=NCCN1	10.1021/jm000542r
	44574875	188750	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	232	1	1	1	3.3	Clc1cccc(C2CCc3nc[nH]c3C2)c1	10.1016/j.bmcl.2009.03.162
	CHEMBL503269	188750	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	232	1	1	1	3.3	Clc1cccc(C2CCc3nc[nH]c3C2)c1	10.1016/j.bmcl.2009.03.162
	44449245	95466	None	0	Human	Functional	pEC50	=	7.3	7.3	6	3	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	2	2	2	2.9	c1cc(-c2ccn[nH]2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	CHEMBL256983	95466	None	0	Human	Functional	pEC50	=	7.3	7.3	6	3	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	250	2	2	2	2.9	c1cc(-c2ccn[nH]2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.03.070
	22493347	119676	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	6	2	5	1.9	CCO/N=C(\C)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL346465	119676	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	6	2	5	1.9	CCO/N=C(\C)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	44281057	99729	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	221	2	1	3	1.9	COc1ccc(OC)c2c1CCCC(N)C2	10.1021/jm00144a012
	CHEMBL284486	99729	None	0	Human	Functional	pEC50	=	5.3	5.3	-	1	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	221	2	1	3	1.9	COc1ccc(OC)c2c1CCCC(N)C2	10.1021/jm00144a012
	9816461	10723	None	4	Human	Functional	pEC50	=	7.3	7.3	60	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL117094	10723	None	4	Human	Functional	pEC50	=	7.3	7.3	60	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL544290	10723	None	4	Human	Functional	pEC50	=	7.3	7.3	60	2	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1AAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1A	ChEMBL	253	4	2	5	0.5	CS(=O)(=O)c1ccccc1NCC1=NCCN1	10.1021/jm000542r
	44574938	189022	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	0	3	2.2	COc1cccc(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.162
	CHEMBL507755	189022	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	0	3	2.2	COc1cccc(C2Cc3nccn3C2)c1	10.1016/j.bmcl.2009.03.162
	44571888	184023	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	246	3	1	2	2.8	COCc1cc(F)cc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL481321	184023	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	246	3	1	2	2.8	COCc1cc(F)cc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	44343244	9954	None	0	Human	Functional	pEC50	=	8.2	8.2	5	2	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	241	3	3	4	2.0	Oc1ccc2cccc(NCC3=NCCN3)c2c1	10.1016/s0960-894x(02)00753-9
	CHEMBL114669	9954	None	0	Human	Functional	pEC50	=	8.2	8.2	5	2	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	241	3	3	4	2.0	Oc1ccc2cccc(NCC3=NCCN3)c2c1	10.1016/s0960-894x(02)00753-9
	44343236	111427	None	0	Human	Functional	pEC50	=	8.2	8.2	15	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	243	4	1	5	1.7	c1ccc(-c2ccno2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	CHEMBL327005	111427	None	0	Human	Functional	pEC50	=	8.2	8.2	15	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	243	4	1	5	1.7	c1ccc(-c2ccno2)c(OCC2=NCCN2)c1	10.1016/s0960-894x(02)00753-9
	9903932	59529	None	0	Human	Functional	pEC50	=	8.2	8.2	501	2	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	284	5	2	6	1.9	CC(C)n1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL17151	59529	None	0	Human	Functional	pEC50	=	8.2	8.2	501	2	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	284	5	2	6	1.9	CC(C)n1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	44271932	65232	None	0	Human	Functional	pEC50	=	8.2	8.2	6	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1ccnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL18256	65232	None	0	Human	Functional	pEC50	=	8.2	8.2	6	3	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	255	4	2	5	1.5	Cn1ccnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	22493392	47169	None	0	Human	Functional	pEC50	=	8.2	8.2	3	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	252	4	2	4	2.2	c1ccc(-c2ccccc2NCC2=NCCN2)nc1	10.1016/s0960-894x(01)00822-8
	CHEMBL154298	47169	None	0	Human	Functional	pEC50	=	8.2	8.2	3	3	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	252	4	2	4	2.2	c1ccc(-c2ccccc2NCC2=NCCN2)nc1	10.1016/s0960-894x(01)00822-8
	9838192	111375	None	18	Rabbit	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at rabbit urethra adrenergic alpha1A receptorAgonist activity at rabbit urethra adrenergic alpha1A receptor	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1016/j.bmc.2008.02.091
	CHEMBL326702	111375	None	18	Rabbit	Functional	pEC50	=	7.2	7.2	-2	3	Agonist activity at rabbit urethra adrenergic alpha1A receptorAgonist activity at rabbit urethra adrenergic alpha1A receptor	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1016/j.bmc.2008.02.091
	122184772	122587	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	424	9	4	6	2.3	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(Cl)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	CHEMBL3601203	122587	None	0	Human	Functional	pEC50	=	7.2	7.2	-1	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	424	9	4	6	2.3	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(Cl)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	44574132	178694	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	280	2	0	4	2.8	Fc1cccc(-c2cncnc2)c1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
	CHEMBL467259	178694	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	280	2	0	4	2.8	Fc1cccc(-c2cncnc2)c1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.166
	44571842	179378	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	242	4	1	2	3.0	CCOCc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL473043	179378	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	242	4	1	2	3.0	CCOCc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	44571887	188523	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	246	3	1	2	2.8	COCc1c(F)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL502078	188523	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	246	3	1	2	2.8	COCc1c(F)ccc2c1CC[C@H]2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	44343243	9847	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	239	3	3	3	2.9	Oc1ccc2cccc(NCc3c[nH]cn3)c2c1	10.1016/s0960-894x(02)00753-9
	CHEMBL114054	9847	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	239	3	3	3	2.9	Oc1ccc2cccc(NCc3c[nH]cn3)c2c1	10.1016/s0960-894x(02)00753-9
	44343173	11025	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	272	6	2	3	2.5	CCN(CC)C(=O)c1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	CHEMBL117482	11025	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	272	6	2	3	2.5	CCN(CC)C(=O)c1ccccc1NCc1c[nH]cn1	10.1016/s0960-894x(02)00753-9
	9838294	59693	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	269	5	2	5	2.0	CCn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL17221	59693	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	269	5	2	5	2.0	CCn1nccc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	11079	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00569-8
	3369	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00569-8
	4436	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00569-8
	4436.0	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00569-8
	5509	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00569-8
	CHEMBL761	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00569-8
	DB06711	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00569-8
	11079	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00822-8
	3369	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00822-8
	4436	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00822-8
	4436.0	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00822-8
	5509	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00822-8
	CHEMBL761	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00822-8
	DB06711	2733	None	38	Human	Functional	pEC50	=	7.2	7.2	5	7	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	210	2	1	2	2.4	C1CN=C(N1)Cc1cccc2c1cccc2	10.1016/s0960-894x(01)00822-8
	25154770	183758	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	246	3	1	2	2.8	COCc1ccc(F)c2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL480272	183758	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	246	3	1	2	2.8	COCc1ccc(F)c2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	22493325	119826	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	257	4	2	6	1.5	Cc1noc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(01)00822-8
	CHEMBL347920	119826	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	257	4	2	6	1.5	Cc1noc(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(01)00822-8
	22493287	120157	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	320	4	2	4	3.2	FC(F)(F)c1cccnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL350906	120157	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	320	4	2	4	3.2	FC(F)(F)c1cccnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	11097789	103053	None	1	Human	Functional	pEC50	=	8.1	8.1	-1	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL306792	103053	None	1	Human	Functional	pEC50	=	8.1	8.1	-1	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	239	4	2	4	2.0	CSc1cc(F)ccc1NCC1=NCCN1	10.1021/jm000542r
	11140345	206629	None	0	Human	Functional	pEC50	=	8.1	8.1	2	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	CHEMBL70692	206629	None	0	Human	Functional	pEC50	=	8.1	8.1	2	5	Agonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptorAgonist potency at Alpha-1 adrenergic receptor assayed in rat-1 fibroblasts expressing human Alpha-1 adrenergic receptor	ChEMBL	239	4	2	4	2.0	CSc1c(F)cccc1NCC1=NCCN1	10.1021/jm000542r
	9795167	107550	None	0	Human	Functional	pEC50	=	8.1	8.1	6	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	260	6	3	4	1.2	CCCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	CHEMBL318544	107550	None	0	Human	Functional	pEC50	=	8.1	8.1	6	3	Activation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblastsActivation of human alpha-1A adrenergic receptor expressed in rat-1 fibroblasts	ChEMBL	260	6	3	4	1.2	CCCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(02)00753-9
	44352155	116872	None	0	Human	Functional	pEC50	=	8.1	8.1	7	5	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	251	4	2	3	2.8	c1ccc(-c2ccccc2NCC2=NCCN2)cc1	10.1016/s0960-894x(01)00764-8
	CHEMBL337862	116872	None	0	Human	Functional	pEC50	=	8.1	8.1	7	5	Activation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathwayActivation of recombinant human adrenergic,alpha-1A receptor expressed in rat-1 fibroblasts determined via calcium mobilization through Gq coupled PLC pathway	ChEMBL	251	4	2	3	2.8	c1ccc(-c2ccccc2NCC2=NCCN2)cc1	10.1016/s0960-894x(01)00764-8
	9795167	107550	None	0	Human	Functional	pEC50	=	8.1	8.1	6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	6	3	4	1.2	CCCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL318544	107550	None	0	Human	Functional	pEC50	=	8.1	8.1	6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	260	6	3	4	1.2	CCCNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44329703	210621	None	0	Human	Functional	pEC50	=	8.1	8.1	7	2	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	4	2	5	2.1	CC(C)(C)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL98243	210621	None	0	Human	Functional	pEC50	=	8.1	8.1	7	2	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	275	4	2	5	2.1	CC(C)(C)OC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	44449304	95658	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	277	3	2	3	1.9	CS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257800	95658	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	277	3	2	3	1.9	CS(=O)(=O)Nc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	12764879	178528	None	0	Human	Functional	pEC50	=	7.2	7.2	100	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	0	2	2.2	c1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL465963	178528	None	0	Human	Functional	pEC50	=	7.2	7.2	100	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	0	2	2.2	c1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	172745	100177	None	2	Human	Functional	pEC50	=	4.2	4.2	-234	2	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	187	2	4	4	0.2	NCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	CHEMBL287587	100177	None	2	Human	Functional	pEC50	=	4.2	4.2	-234	2	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	187	2	4	4	0.2	NCC(O)c1ccc(O)c(O)c1F	10.1021/jm00118a019
	1753	2504	None	16	Human	Functional	pEC50	=	6.1	6.1	2	4	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1021/jm00144a012
	483	2504	None	16	Human	Functional	pEC50	=	6.1	6.1	2	4	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1021/jm00144a012
	6082	2504	None	16	Human	Functional	pEC50	=	6.1	6.1	2	4	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1021/jm00144a012
	6082.0	2504	None	16	Human	Functional	pEC50	=	6.1	6.1	2	4	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1021/jm00144a012
	CHEMBL524	2504	None	16	Human	Functional	pEC50	=	6.1	6.1	2	4	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1021/jm00144a012
	DB00723	2504	None	16	Human	Functional	pEC50	=	6.1	6.1	2	4	Alpha-1 adrenergic receptor agonist activity in rabbit ear arteryAlpha-1 adrenergic receptor agonist activity in rabbit ear artery	ChEMBL	211	4	2	4	1.1	COc1ccc(c(c1)C(C(N)C)O)OC	10.1021/jm00144a012
	12764880	178651	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	0	2	2.6	c1ccc(C2CCc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL466914	178651	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	198	1	0	2	2.6	c1ccc(C2CCc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	22493359	121753	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	257	4	2	6	1.5	Cc1nc(-c2ccccc2NCC2=NCCN2)no1	10.1016/s0960-894x(01)00822-8
	CHEMBL358685	121753	None	0	Human	Functional	pEC50	=	6.1	6.1	-1	2	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	257	4	2	6	1.5	Cc1nc(-c2ccccc2NCC2=NCCN2)no1	10.1016/s0960-894x(01)00822-8
	12764879	178528	None	0	Human	Functional	pEC50	=	7.1	7.1	100	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	0	2	2.2	c1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL465963	178528	None	0	Human	Functional	pEC50	=	7.1	7.1	100	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	0	2	2.2	c1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	44593580	178647	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	242	3	1	2	2.8	COCc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL466876	178647	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	242	3	1	2	2.8	COCc1ccccc1C1CCc2nc[nH]c2C1	10.1016/j.bmcl.2009.03.162
	44449303	95657	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	284	2	2	2	3.5	Clc1ccc2c(c1-c1cn[nH]c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	CHEMBL257799	95657	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	284	2	2	2	3.5	Clc1ccc2c(c1-c1cn[nH]c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.03.070
	44449303	95657	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	284	2	2	2	3.5	Clc1ccc2c(c1-c1cn[nH]c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL257799	95657	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	284	2	2	2	3.5	Clc1ccc2c(c1-c1cn[nH]c1)CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	9840212	62141	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	324	5	2	6	1.9	FC(F)(F)Cn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	CHEMBL17764	62141	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	324	5	2	6	1.9	FC(F)(F)Cn1ncnc1-c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(03)00050-7
	44329133	210160	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	6	3	4	1.5	CC(C)CNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	CHEMBL95565	210160	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.Agonist potency against cloned human alpha 1A adrenoceptor expressed in rat-1 fibroblasts.	ChEMBL	274	6	3	4	1.5	CC(C)CNC(=O)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00569-8
	22493408	61219	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	256	4	3	5	1.2	Cc1n[nH]c(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(03)00050-7
	CHEMBL17657	61219	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cellsAgonism of human alpha-1A adrenergic receptor expressed in rat 1 fibroblast cells	ChEMBL	256	4	3	5	1.2	Cc1n[nH]c(-c2ccccc2NCC2=NCCN2)n1	10.1016/s0960-894x(03)00050-7
	541604	165434	None	7	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	201	3	4	4	0.5	CNCC(O)c1cc(O)c(O)cc1F	10.1021/jm00118a019
	CHEMBL42359	165434	None	7	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortexAgonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pig cerebral cortex	ChEMBL	201	3	4	4	0.5	CNCC(O)c1cc(O)c(O)cc1F	10.1021/jm00118a019
	44574079	189418	None	0	Human	Functional	pEC50	=	7.1	7.1	8	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	0	3	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL512289	189418	None	0	Human	Functional	pEC50	=	7.1	7.1	8	2	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	261	2	0	3	3.3	c1ccc([C@@H]2Cc3nccn3C2)c(-c2ccncc2)c1	10.1016/j.bmcl.2009.03.166
	11522042	206137	None	0	Rat	Functional	pEC50	=	6.1	6.1	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	284	2	0	3	3.2	Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2006.02.003
	CHEMBL67457	206137	None	0	Rat	Functional	pEC50	=	6.1	6.1	-	1	Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionVasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contraction	ChEMBL	284	2	0	3	3.2	Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1016/j.bmcl.2006.02.003
	45381933	122605	None	0	Human	Functional	pEC50	=	6.1	6.1	-12	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	458	9	4	6	2.7	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C(F)(F)F)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	CHEMBL3601308	122605	None	0	Human	Functional	pEC50	=	6.1	6.1	-12	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	458	9	4	6	2.7	CS(=O)(=O)Nc1cccc([C@@H](O)CNCCOc2ccc3c(C(F)(F)F)n[nH]c3c2)c1	10.1021/acs.jmedchem.5b00638
	44574989	189339	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	3	0	3	2.4	COCc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	CHEMBL511577	189339	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	228	3	0	3	2.4	COCc1ccccc1C1Cc2nccn2C1	10.1016/j.bmcl.2009.03.162
	12764879	178528	None	0	Human	Functional	pEC50	=	7.1	7.1	100	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	0	2	2.2	c1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL465963	178528	None	0	Human	Functional	pEC50	=	7.1	7.1	100	2	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	184	1	0	2	2.2	c1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	44571840	188320	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	276	3	1	3	2.0	CS(=O)(=O)Cc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	CHEMBL499180	188320	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	276	3	1	3	2.0	CS(=O)(=O)Cc1cccc2c1CCC2c1ncc[nH]1	10.1016/j.bmcl.2008.10.066
	45381852	122588	None	0	Human	Functional	pEC50	=	6.1	6.1	-60	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	418	10	4	6	2.2	CCc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	CHEMBL3601204	122588	None	0	Human	Functional	pEC50	=	6.1	6.1	-60	2	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	418	10	4	6	2.2	CCc1n[nH]c2cc(OCCNC[C@H](O)c3cccc(NS(C)(=O)=O)c3)ccc12	10.1021/acs.jmedchem.5b00638
	22493254	169191	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	6	2	5	1.9	CC/C(=N/OC)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	CHEMBL439822	169191	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	In vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assayIn vitro activation of human alpha-1A receptor expressed in rat-1 fibroblasts via calcium mobilization through the Gq coupled PLC pathway as functional assay	ChEMBL	260	6	2	5	1.9	CC/C(=N/OC)c1ccccc1NCC1=NCCN1	10.1016/s0960-894x(01)00822-8
	44571845	189243	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	289	3	1	2	2.9	FC1(F)CN(Cc2cccc3c2CCC3c2ncc[nH]2)C1	10.1016/j.bmcl.2008.10.066
	CHEMBL510613	189243	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	289	3	1	2	2.9	FC1(F)CN(Cc2cccc3c2CCC3c2ncc[nH]2)C1	10.1016/j.bmcl.2008.10.066
	2803	955	None	40	Bovine	Functional	pEC50	=	7.1	7.1	-6	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	2803.0	955	None	40	Bovine	Functional	pEC50	=	7.1	7.1	-6	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	516	955	None	40	Bovine	Functional	pEC50	=	7.1	7.1	-6	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	704	955	None	40	Bovine	Functional	pEC50	=	7.1	7.1	-6	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	CHEMBL134	955	None	40	Bovine	Functional	pEC50	=	7.1	7.1	-6	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	DB00575	955	None	40	Bovine	Functional	pEC50	=	7.1	7.1	-6	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	229	1	2	3	2.4	Clc1cccc(c1NC1=NCCN1)Cl	nan
	2146	3100	None	45	Bovine	Functional	pEC50	=	8.1	8.1	1	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	485	3100	None	45	Bovine	Functional	pEC50	=	8.1	8.1	1	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	6041	3100	None	45	Bovine	Functional	pEC50	=	8.1	8.1	1	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	6041.0	3100	None	45	Bovine	Functional	pEC50	=	8.1	8.1	1	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	CHEMBL1215	3100	None	45	Bovine	Functional	pEC50	=	8.1	8.1	1	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	DB00388	3100	None	45	Bovine	Functional	pEC50	=	8.1	8.1	1	14	Agonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assayAgonist activity at bovine recombinant alpha-1A receptor expressed in HEK293 cells coexpressing Gag-pol assessed as increase in intracellular calcium measured after 60 mins by fluo-4 dye based FLIPR assay	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	nan
	44574080	189054	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	264	2	0	4	2.6	Cn1cc(-c2ccccc2[C@@H]2Cc3nccn3C2)cn1	10.1016/j.bmcl.2009.03.166
	CHEMBL508084	189054	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	264	2	0	4	2.6	Cn1cc(-c2ccccc2[C@@H]2Cc3nccn3C2)cn1	10.1016/j.bmcl.2009.03.166
	9838192	111375	None	18	Human	Functional	pEC50	=	8.1	8.1	2	3	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1016/j.bmcl.2008.03.070
	CHEMBL326702	111375	None	18	Human	Functional	pEC50	=	8.1	8.1	2	3	Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	265	5	2	3	1.8	CCS(=O)(=O)Nc1cccc(Cc2c[nH]cn2)c1	10.1016/j.bmcl.2008.03.070
	44571938	180179	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	300	3	1	3	3.0	Fc1ccn(Cc2c(F)ccc3c2CC[C@H]3c2ncc[nH]2)n1	10.1016/j.bmcl.2008.10.066
	CHEMBL474796	180179	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	300	3	1	3	3.0	Fc1ccn(Cc2c(F)ccc3c2CC[C@H]3c2ncc[nH]2)n1	10.1016/j.bmcl.2008.10.066
	1960	2857	None	46	Human	Functional	pEC50	=	8.0	8.0	-2	18	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jmedchem.5b00638
	439260	2857	None	46	Human	Functional	pEC50	=	8.0	8.0	-2	18	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jmedchem.5b00638
	439260.0	2857	None	46	Human	Functional	pEC50	=	8.0	8.0	-2	18	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jmedchem.5b00638
	505	2857	None	46	Human	Functional	pEC50	=	8.0	8.0	-2	18	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jmedchem.5b00638
	CHEMBL1437	2857	None	46	Human	Functional	pEC50	=	8.0	8.0	-2	18	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jmedchem.5b00638
	DB00368	2857	None	46	Human	Functional	pEC50	=	8.0	8.0	-2	18	Agonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assayAgonist activity at human alpha1A-adrenergic receptor expressed in HEK293 cells assessed as calcium flux by fluorescence assay	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/acs.jmedchem.5b00638
	44571890	192085	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	265	3	1	4	2.1	c1cc(Cn2ccnn2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.10.066
	CHEMBL520117	192085	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assayAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells by calcium mobilization-based fluorescence assay	ChEMBL	265	3	1	4	2.1	c1cc(Cn2ccnn2)c2c(c1)C(c1ncc[nH]1)CC2	10.1016/j.bmcl.2008.10.066
	44574076	172564	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	251	2	0	4	2.9	c1ccc([C@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
	CHEMBL448147	172564	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	251	2	0	4	2.9	c1ccc([C@H]2Cc3nccn3C2)c(-c2ncco2)c1	10.1016/j.bmcl.2009.03.166
	44574985	188514	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	0	3	2.2	COc1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	CHEMBL501920	188514	None	0	Human	Functional	pEC50	=	6.0	6.0	-	1	Agonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPRAgonist activity at human cloned adrenergic alpha1A receptor expressed in CHO cells assessed as calcium mobilization by FLIPR	ChEMBL	214	2	0	3	2.2	COc1ccc(C2Cc3nccn3C2)cc1	10.1016/j.bmcl.2009.03.162
	123562321	140598	None	0	Human	Functional	pIC50	=	9.5	9.5	1	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	443	12	3	6	2.9	COc1ccc(F)cc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3810110	140598	None	0	Human	Functional	pIC50	=	9.5	9.5	1	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	443	12	3	6	2.9	COc1ccc(F)cc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	129211	3749	None	48	Human	Functional	pIC50	=	9.5	9.5	-1	14	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1016/j.ejmech.2020.112616
	129211.0	3749	None	48	Human	Functional	pIC50	=	9.5	9.5	-1	14	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1016/j.ejmech.2020.112616
	2562	3749	None	48	Human	Functional	pIC50	=	9.5	9.5	-1	14	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1016/j.ejmech.2020.112616
	488	3749	None	48	Human	Functional	pIC50	=	9.5	9.5	-1	14	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1016/j.ejmech.2020.112616
	CHEMBL836	3749	None	48	Human	Functional	pIC50	=	9.5	9.5	-1	14	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1016/j.ejmech.2020.112616
	DB00706	3749	None	48	Human	Functional	pIC50	=	9.5	9.5	-1	14	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1016/j.ejmech.2020.112616
	499	4077	None	13	Human	Functional	pIC50	=	9	9.0	-	1	Antagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levelsAntagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levels	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1016/j.ejmech.2014.12.045
	5685	4077	None	13	Human	Functional	pIC50	=	9	9.0	-	1	Antagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levelsAntagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levels	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1016/j.ejmech.2014.12.045
	CHEMBL25554	4077	None	13	Human	Functional	pIC50	=	9	9.0	-	1	Antagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levelsAntagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levels	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1016/j.ejmech.2014.12.045
	499	4077	None	13	Human	Functional	pIC50	=	9	9.0	-	1	Antagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ release	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm401895u
	5685	4077	None	13	Human	Functional	pIC50	=	9	9.0	-	1	Antagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ release	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm401895u
	CHEMBL25554	4077	None	13	Human	Functional	pIC50	=	9	9.0	-	1	Antagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ releaseAntagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ release	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm401895u
	123854385	140603	None	0	Human	Functional	pIC50	=	8.9	8.9	72	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	527	13	3	6	4.3	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3810145	140603	None	0	Human	Functional	pIC50	=	8.9	8.9	72	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	527	13	3	6	4.3	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	4151	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.6b01217
	493	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.6b01217
	5312125	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.6b01217
	5312125.0	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.6b01217
	CHEMBL24778	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.6b01217
	DB06207	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.6b01217
	4151	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.5b02023
	493	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.5b02023
	5312125	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.5b02023
	5312125.0	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.5b02023
	CHEMBL24778	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.5b02023
	DB06207	3607	None	59	Human	Functional	pIC50	=	8.7	8.7	1	11	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1021/acs.jmedchem.5b02023
	9913616	140470	None	8	Human	Functional	pIC50	=	8.7	8.7	8	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	493	13	3	6	3.7	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3808572	140470	None	8	Human	Functional	pIC50	=	8.7	8.7	8	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	493	13	3	6	3.7	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	10160408	140527	None	0	Human	Functional	pIC50	=	8.7	8.7	1	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	439	13	3	6	3.1	CCOc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809248	140527	None	0	Human	Functional	pIC50	=	8.7	8.7	1	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	439	13	3	6	3.1	CCOc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	86344174	140555	None	0	Human	Functional	pIC50	=	8.7	8.7	251	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	507	13	3	6	4.0	Cc1ccc(OCC(F)(F)F)c(OCCN[C@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809490	140555	None	0	Human	Functional	pIC50	=	8.7	8.7	251	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	507	13	3	6	4.0	Cc1ccc(OCC(F)(F)F)c(OCCN[C@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	2389	3331	None	72	Human	Functional	pIC50	=	8	8.0	-13	29	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	5073	3331	None	72	Human	Functional	pIC50	=	8	8.0	-13	29	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	5073.0	3331	None	72	Human	Functional	pIC50	=	8	8.0	-13	29	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	96	3331	None	72	Human	Functional	pIC50	=	8	8.0	-13	29	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	CHEMBL85	3331	None	72	Human	Functional	pIC50	=	8	8.0	-13	29	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	DB00734	3331	None	72	Human	Functional	pIC50	=	8	8.0	-13	29	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2018.01.038
	2389	3331	None	72	Human	Functional	pIC50	=	8.0	8.0	-13	29	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	5073	3331	None	72	Human	Functional	pIC50	=	8.0	8.0	-13	29	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	5073.0	3331	None	72	Human	Functional	pIC50	=	8.0	8.0	-13	29	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	96	3331	None	72	Human	Functional	pIC50	=	8.0	8.0	-13	29	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	CHEMBL85	3331	None	72	Human	Functional	pIC50	=	8.0	8.0	-13	29	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	DB00734	3331	None	72	Human	Functional	pIC50	=	8.0	8.0	-13	29	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.ejmech.2017.12.099
	145946682	167673	None	0	Human	Functional	pIC50	=	6.0	6.0	-10	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	444	7	0	3	5.6	Fc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	CHEMBL4225239	167673	None	0	Human	Functional	pIC50	=	6.0	6.0	-10	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	444	7	0	3	5.6	Fc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	CHEMBL4300633	167673	None	0	Human	Functional	pIC50	=	6.0	6.0	-10	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	444	7	0	3	5.6	Fc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	145964299	164227	None	0	Human	Functional	pIC50	=	8.0	8.0	-1	6	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4210030	164227	None	0	Human	Functional	pIC50	=	8.0	8.0	-1	6	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	426	8	1	6	3.8	CNC(=O)c1cc(OCCCCN2CCC(c3noc4cc(F)ccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	76071739	142884	None	0	Human	Functional	pIC50	=	7.9	7.9	-25	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2[nH]c3c(c2c1)C[C@H]1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3892879	142884	None	0	Human	Functional	pIC50	=	7.9	7.9	-25	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2[nH]c3c(c2c1)C[C@H]1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	145946986	167705	None	0	Human	Functional	pIC50	=	5.9	5.9	-4	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	460	7	0	3	6.2	Clc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1	10.1016/j.bmcl.2018.03.070
	CHEMBL4227241	167705	None	0	Human	Functional	pIC50	=	5.9	5.9	-4	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	460	7	0	3	6.2	Clc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1	10.1016/j.bmcl.2018.03.070
	CHEMBL4300995	167705	None	0	Human	Functional	pIC50	=	5.9	5.9	-4	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	460	7	0	3	6.2	Clc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1	10.1016/j.bmcl.2018.03.070
	145990794	166896	None	0	Human	Functional	pIC50	=	6.9	6.9	-19	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4284346	166896	None	0	Human	Functional	pIC50	=	6.9	6.9	-19	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	437	6	0	5	3.8	O=C1[C@H]2[C@@H]3CC[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	131978695	150950	None	0	Human	Functional	pIC50	=	6.9	6.9	5	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	440	5	1	4	5.4	COc1ccc2[nH]c3c(c2c1)CC1c2cc(OCc4ccccc4)c(OC)cc2CCN1C3	10.1021/acs.jmedchem.6b01217
	CHEMBL3957222	150950	None	0	Human	Functional	pIC50	=	6.9	6.9	5	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	440	5	1	4	5.4	COc1ccc2[nH]c3c(c2c1)CC1c2cc(OCc4ccccc4)c(OC)cc2CCN1C3	10.1021/acs.jmedchem.6b01217
	134138882	147816	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	318	0	1	3	3.6	c1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2C1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3932187	147816	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	318	0	1	3	3.6	c1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2C1C3)OCO4	10.1021/acs.jmedchem.6b01217
	44575544	174102	None	0	Human	Functional	pIC50	=	7.9	7.9	-3	4	Inhibition of adrenergic receptor 1a expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetryInhibition of adrenergic receptor 1a expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetry	ChEMBL	794	5	5	13	3.0	CC(C)CC(=O)O[C@H]1/C=C/C=C/C(=O)O[C@H]2[C@@H](C)C[C@@H]3[C@]2(O)[C@H](O)[C@@]2(CO)O[C@H]2[C@H]2[C@H]4OC5(c6ccccc6)O[C@@H]([C@@H](C)[C@@]23O5)[C@@]4(O)[C@](C)(O)C[C@H]2CC[C@H]1[C@H]2C	10.1021/np3000359
	CHEMBL454246	174102	None	0	Human	Functional	pIC50	=	7.9	7.9	-3	4	Inhibition of adrenergic receptor 1a expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetryInhibition of adrenergic receptor 1a expressed in HEK293 cells assessed as inhibition of calcium influx after 10 mins by Fluo-4-AM based fluorimetry	ChEMBL	794	5	5	13	3.0	CC(C)CC(=O)O[C@H]1/C=C/C=C/C(=O)O[C@H]2[C@@H](C)C[C@@H]3[C@]2(O)[C@H](O)[C@@]2(CO)O[C@H]2[C@H]2[C@H]4OC5(c6ccccc6)O[C@@H]([C@@H](C)[C@@]23O5)[C@@]4(O)[C@](C)(O)C[C@H]2CC[C@H]1[C@H]2C	10.1021/np3000359
	127044893	140495	None	0	Human	Functional	pIC50	=	7.8	7.8	2	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	411	11	3	5	2.4	Cc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3808878	140495	None	0	Human	Functional	pIC50	=	7.8	7.8	2	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	411	11	3	5	2.4	Cc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	134157118	154291	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	332	0	0	4	3.6	Cn1c2c(c3ccccc31)CC1c3cc4c(cc3CCN1C2)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3985901	154291	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	332	0	0	4	3.6	Cn1c2c(c3ccccc31)CC1c3cc4c(cc3CCN1C2)OCO4	10.1021/acs.jmedchem.6b01217
	123141715	140622	None	0	Human	Functional	pIC50	=	7.8	7.8	2	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	459	12	3	6	3.4	COc1cc(Cl)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3810401	140622	None	0	Human	Functional	pIC50	=	7.8	7.8	2	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	459	12	3	6	3.4	COc1cc(Cl)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	44347716	16315	None	0	Rat	Functional	pIC50	=	4.8	4.8	4	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	590	27	4	8	6.3	COc1cccc(CNCCCCCCNCCSSCCNCCCCCCNCc2ccccc2OC)c1	10.1021/jm000995w
	CHEMBL122621	16315	None	0	Rat	Functional	pIC50	=	4.8	4.8	4	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	590	27	4	8	6.3	COc1cccc(CNCCCCCCNCCSSCCNCCCCCCNCc2ccccc2OC)c1	10.1021/jm000995w
	145966333	164155	None	0	Human	Functional	pIC50	=	6.8	6.8	-134	6	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4209188	164155	None	0	Human	Functional	pIC50	=	6.8	6.8	-134	6	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	424	8	1	6	3.6	CNC(=O)c1cc(OCCCCN2CCN(c3cccc4sccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	123986550	140485	None	0	Human	Functional	pIC50	=	7.8	7.8	223	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	521	14	3	6	4.2	CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3808717	140485	None	0	Human	Functional	pIC50	=	7.8	7.8	223	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	521	14	3	6	4.2	CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	134142282	145778	None	0	Human	Functional	pIC50	=	7.8	7.8	2	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3916182	145778	None	0	Human	Functional	pIC50	=	7.8	7.8	2	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	242	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	34	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	60795	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	60795.0	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	CHEMBL1112	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	DB01238	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2017.12.099
	242	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	34	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	60795	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	60795.0	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	CHEMBL1112	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	DB01238	470	None	70	Human	Functional	pIC50	=	6.8	6.8	-120	33	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmcl.2018.01.038
	145983928	166507	None	0	Human	Functional	pIC50	=	6.8	6.8	-48	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4277101	166507	None	0	Human	Functional	pIC50	=	6.8	6.8	-48	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	435	6	0	5	3.6	O=C1[C@H]2[C@@H]3C=C[C@@H](C3)[C@H]2C(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	10820251	96675	None	0	Rat	Functional	pIC50	=	5.7	5.7	-1	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCNCCSSCCNCCCCCCNCc3ccccc3C(=O)N(C)CCCCCCN(C)c3nc(N)c4cc(OC)c(OC)cc4n3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL1203233	96675	None	0	Rat	Functional	pIC50	=	5.7	5.7	-1	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCNCCSSCCNCCCCCCNCc3ccccc3C(=O)N(C)CCCCCCN(C)c3nc(N)c4cc(OC)c(OC)cc4n3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL263434	96675	None	0	Rat	Functional	pIC50	=	5.7	5.7	-1	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCNCCSSCCNCCCCCCNCc3ccccc3C(=O)N(C)CCCCCCN(C)c3nc(N)c4cc(OC)c(OC)cc4n3)nc(N)c2cc1OC	10.1021/jm000995w
	10606263	141638	None	0	Rat	Functional	pIC50	=	5.7	5.7	20	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1161	33	6	20	7.3	COc1cc2nc(N3CCN(C(=O)c4ccc(CNCCCCCCNCCSSCCNCCCCCCNCc5ccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)cc5)cc4)CC3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL384790	141638	None	0	Rat	Functional	pIC50	=	5.7	5.7	20	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1161	33	6	20	7.3	COc1cc2nc(N3CCN(C(=O)c4ccc(CNCCCCCCNCCSSCCNCCCCCCNCc5ccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)cc5)cc4)CC3)nc(N)c2cc1OC	10.1021/jm000995w
	123472560	140581	None	0	Human	Functional	pIC50	=	8.7	8.7	616	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	507	13	3	6	4.0	Cc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809840	140581	None	0	Human	Functional	pIC50	=	8.7	8.7	616	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	507	13	3	6	4.0	Cc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	129211	3749	None	48	Human	Functional	pIC50	=	8.7	8.7	-1	14	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/acs.jmedchem.6b01217
	129211.0	3749	None	48	Human	Functional	pIC50	=	8.7	8.7	-1	14	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/acs.jmedchem.6b01217
	2562	3749	None	48	Human	Functional	pIC50	=	8.7	8.7	-1	14	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/acs.jmedchem.6b01217
	488	3749	None	48	Human	Functional	pIC50	=	8.7	8.7	-1	14	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/acs.jmedchem.6b01217
	CHEMBL836	3749	None	48	Human	Functional	pIC50	=	8.7	8.7	-1	14	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/acs.jmedchem.6b01217
	DB00706	3749	None	48	Human	Functional	pIC50	=	8.7	8.7	-1	14	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/acs.jmedchem.6b01217
	123415538	140464	None	0	Human	Functional	pIC50	=	8.6	8.6	8	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	491	11	3	5	3.6	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccc(F)cc1Br	10.1021/acs.jmedchem.5b02023
	CHEMBL3808511	140464	None	0	Human	Functional	pIC50	=	8.6	8.6	8	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	491	11	3	5	3.6	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccc(F)cc1Br	10.1021/acs.jmedchem.5b02023
	123667086	140486	None	0	Human	Functional	pIC50	=	8.6	8.6	-8	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	573	13	3	6	3.8	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Br)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3808726	140486	None	0	Human	Functional	pIC50	=	8.6	8.6	-8	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	573	13	3	6	3.8	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Br)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	127044912	140515	None	0	Human	Functional	pIC50	=	8.6	8.6	-26	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	501	14	3	6	4.3	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCc1ccccc1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809093	140515	None	0	Human	Functional	pIC50	=	8.6	8.6	-26	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	501	14	3	6	4.3	CC(Cc1cc(C(N)=O)c2c(ccn2CCCO)c1)NCCOc1ccccc1OCc1ccccc1	10.1021/acs.jmedchem.5b02023
	117839022	140618	None	0	Human	Functional	pIC50	=	8.6	8.6	407	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	529	13	3	6	3.7	C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3810346	140618	None	0	Human	Functional	pIC50	=	8.6	8.6	407	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	529	13	3	6	3.7	C[C@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	124018870	140498	None	0	Human	Functional	pIC50	=	8.5	8.5	-7	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	445	12	3	6	2.3	COc1ccc(F)cc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3808896	140498	None	0	Human	Functional	pIC50	=	8.5	8.5	-7	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	445	12	3	6	2.3	COc1ccc(F)cc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	123368349	140520	None	0	Human	Functional	pIC50	=	8.5	8.5	95	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	505	12	3	6	2.9	COc1cc(Br)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3809175	140520	None	0	Human	Functional	pIC50	=	8.5	8.5	95	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	505	12	3	6	2.9	COc1cc(Br)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	123387804	140508	None	0	Human	Functional	pIC50	=	7.7	7.7	-52	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	423	12	3	5	3.3	CCc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3808999	140508	None	0	Human	Functional	pIC50	=	7.7	7.7	-52	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	423	12	3	5	3.3	CCc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	156767236	183063	None	0	Human	Functional	pIC50	=	7.7	7.7	9	2	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	449	11	1	5	4.7	COc1ccccc1N1CCN(CCCCn2cc(CCCC(=O)O)c3ccccc32)CC1	10.1016/j.ejmech.2020.112616
	CHEMBL4792905	183063	None	0	Human	Functional	pIC50	=	7.7	7.7	9	2	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	449	11	1	5	4.7	COc1ccccc1N1CCN(CCCCn2cc(CCCC(=O)O)c3ccccc32)CC1	10.1016/j.ejmech.2020.112616
	134157566	154115	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1cccc2[nH]c3c(c12)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3984249	154115	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1cccc2[nH]c3c(c12)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	134137522	143185	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	336	0	1	3	3.7	Fc1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2C1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3895460	143185	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	336	0	1	3	3.7	Fc1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2C1C3)OCO4	10.1021/acs.jmedchem.6b01217
	123204312	140559	None	0	Human	Functional	pIC50	=	7.7	7.7	74	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	425	11	3	5	2.7	Cc1cccc(C)c1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3809532	140559	None	0	Human	Functional	pIC50	=	7.7	7.7	74	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	425	11	3	5	2.7	Cc1cccc(C)c1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	134150827	152256	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	392	5	1	4	4.6	CCCOc1cc2c(cc1OC)CCN1Cc3[nH]c4ccc(OC)cc4c3CC21	10.1021/acs.jmedchem.6b01217
	CHEMBL3968227	152256	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	392	5	1	4	4.6	CCCOc1cc2c(cc1OC)CCN1Cc3[nH]c4ccc(OC)cc4c3CC21	10.1021/acs.jmedchem.6b01217
	134155537	151074	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	406	6	1	4	5.0	CCCCOc1cc2c(cc1OC)CCN1Cc3[nH]c4ccc(OC)cc4c3CC21	10.1021/acs.jmedchem.6b01217
	CHEMBL3958316	151074	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	406	6	1	4	5.0	CCCCOc1cc2c(cc1OC)CCN1Cc3[nH]c4ccc(OC)cc4c3CC21	10.1021/acs.jmedchem.6b01217
	123322716	140610	None	0	Human	Functional	pIC50	=	7.6	7.6	17	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	425	12	3	5	2.7	CCc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3810198	140610	None	0	Human	Functional	pIC50	=	7.6	7.6	17	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	425	12	3	5	2.7	CCc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	134149598	148565	None	0	Human	Functional	pIC50	=	6.6	6.6	33	2	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	336	0	1	3	3.7	Fc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3938121	148565	None	0	Human	Functional	pIC50	=	6.6	6.6	33	2	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	336	0	1	3	3.7	Fc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	123801568	140576	None	0	Human	Functional	pIC50	=	7.6	7.6	100	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	441	11	3	7	1.9	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc2c(c1)OCO2	10.1021/acs.jmedchem.5b02023
	CHEMBL3809781	140576	None	0	Human	Functional	pIC50	=	7.6	7.6	100	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	441	11	3	7	1.9	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc2c(c1)OCO2	10.1021/acs.jmedchem.5b02023
	134150128	152189	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	424	3	1	4	5.1	c1ccc(COc2ccc3[nH]c4c(c3c2)CC2c3cc5c(cc3CCN2C4)OCO5)cc1	10.1021/acs.jmedchem.6b01217
	CHEMBL3967696	152189	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	424	3	1	4	5.1	c1ccc(COc2ccc3[nH]c4c(c3c2)CC2c3cc5c(cc3CCN2C4)OCO5)cc1	10.1021/acs.jmedchem.6b01217
	9891967	107581	None	21	Human	Functional	pIC50	=	8.5	8.5	4	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3187195	107581	None	21	Human	Functional	pIC50	=	8.5	8.5	4	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	495	13	3	6	3.1	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	123644751	140590	None	0	Human	Functional	pIC50	=	8.5	8.5	125	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	529	13	3	6	3.7	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3810005	140590	None	0	Human	Functional	pIC50	=	8.5	8.5	125	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	529	13	3	6	3.7	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	123475619	140578	None	0	Human	Functional	pIC50	=	8.4	8.4	43	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	503	12	3	6	3.5	COc1cc(Br)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809794	140578	None	0	Human	Functional	pIC50	=	8.4	8.4	43	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	503	12	3	6	3.5	COc1cc(Br)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	76071859	150441	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2[nH]c3c(c2c1)C[C@@H]1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3953156	150441	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2[nH]c3c(c2c1)C[C@@H]1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	156767234	182702	None	0	Human	Functional	pIC50	=	7.5	7.5	10	2	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	467	11	1	4	5.7	O=C(O)CCCc1cn(CCCCCN2CCN(c3ccccc3Cl)CC2)c2ccccc12	10.1016/j.ejmech.2020.112616
	CHEMBL4788144	182702	None	0	Human	Functional	pIC50	=	7.5	7.5	10	2	Antagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assayAntagonist activity at human alpha1A receptor transfected in HEK293 cells co-transfected with Galpha16 assessed as reduction in intracellular calcium release incubated for 40 mins by Fluo-4AM dye based fluorescence assay	ChEMBL	467	11	1	4	5.7	O=C(O)CCCc1cn(CCCCCN2CCN(c3ccccc3Cl)CC2)c2ccccc12	10.1016/j.ejmech.2020.112616
	123393714	140561	None	0	Human	Functional	pIC50	=	6.5	6.5	3	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	439	11	3	5	3.1	Cc1ccc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1C	10.1021/acs.jmedchem.5b02023
	CHEMBL3809543	140561	None	0	Human	Functional	pIC50	=	6.5	6.5	3	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	439	11	3	5	3.1	Cc1ccc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1C	10.1021/acs.jmedchem.5b02023
	145993493	167453	None	0	Human	Functional	pIC50	=	6.4	6.4	-47	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	439	6	0	5	4.5	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	CHEMBL4294617	167453	None	0	Human	Functional	pIC50	=	6.4	6.4	-47	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	439	6	0	5	4.5	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2cccc3sccc23)CC1	10.1016/j.ejmech.2017.12.099
	145993117	167017	None	0	Human	Functional	pIC50	=	6.4	6.4	-309	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	427	7	0	5	4.4	CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	CHEMBL4286717	167017	None	0	Human	Functional	pIC50	=	6.4	6.4	-309	6	Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayAntagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assay	ChEMBL	427	7	0	5	4.4	CCC1(C)CC(=O)N(CCCCN2CCN(c3cccc4sccc34)CC2)C(=O)C1	10.1016/j.ejmech.2017.12.099
	123311113	140608	None	0	Human	Functional	pIC50	=	7.4	7.4	91	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	523	14	3	6	3.6	CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3810187	140608	None	0	Human	Functional	pIC50	=	7.4	7.4	91	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	523	14	3	6	3.6	CCc1ccc(OCC(F)(F)F)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c1	10.1021/acs.jmedchem.5b02023
	10582125	81865	None	0	Rat	Functional	pIC50	=	5.4	5.4	14	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1161	33	6	20	7.3	COc1cc2nc(N3CCN(C(=O)c4cccc(CNCCCCCCNCCSSCCNCCCCCCNCc5cccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)c5)c4)CC3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL216443	81865	None	0	Rat	Functional	pIC50	=	5.4	5.4	14	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1161	33	6	20	7.3	COc1cc2nc(N3CCN(C(=O)c4cccc(CNCCCCCCNCCSSCCNCCCCCCNCc5cccc(C(=O)N6CCN(c7nc(N)c8cc(OC)c(OC)cc8n7)CC6)c5)c4)CC3)nc(N)c2cc1OC	10.1021/jm000995w
	123688273	140568	None	0	Human	Functional	pIC50	=	8.4	8.4	36	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	513	13	3	6	3.2	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3809630	140568	None	0	Human	Functional	pIC50	=	8.4	8.4	36	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	513	13	3	6	3.2	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	127044911	140535	None	0	Human	Functional	pIC50	=	8.4	8.4	-10	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	425	12	3	6	2.7	COc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809319	140535	None	0	Human	Functional	pIC50	=	8.4	8.4	-10	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	425	12	3	6	2.7	COc1ccccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	123183757	140564	None	0	Human	Functional	pIC50	=	8.3	8.3	10	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	445	12	3	6	2.3	COc1cc(F)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3809600	140564	None	0	Human	Functional	pIC50	=	8.3	8.3	10	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	445	12	3	6	2.3	COc1cc(F)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	127044894	140454	None	0	Human	Functional	pIC50	=	8.3	8.3	3	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	427	12	3	6	2.1	COc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3808408	140454	None	0	Human	Functional	pIC50	=	8.3	8.3	3	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	427	12	3	6	2.1	COc1ccccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	134147190	149886	None	0	Human	Functional	pIC50	=	6.4	6.4	3	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	334	0	2	4	3.3	Oc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3948551	149886	None	0	Human	Functional	pIC50	=	6.4	6.4	3	3	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	334	0	2	4	3.3	Oc1ccc2[nH]c3c(c2c1)CC1c2cc4c(cc2CCN1C3)OCO4	10.1021/acs.jmedchem.6b01217
	10034370	157084	None	0	Rat	Functional	pIC50	=	7.3	7.3	38	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CNCCCCCCNCCSSCCNCCCCCCNCc4cccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)c4)c3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL1203232	157084	None	0	Rat	Functional	pIC50	=	7.3	7.3	38	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CNCCCCCCNCCSSCCNCCCCCCNCc4cccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)c4)c3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL407315	157084	None	0	Rat	Functional	pIC50	=	7.3	7.3	38	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3cccc(CNCCCCCCNCCSSCCNCCCCCCNCc4cccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)c4)c3)nc(N)c2cc1OC	10.1021/jm000995w
	127043026	140534	None	0	Human	Functional	pIC50	=	6.3	6.3	8	2	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	507	13	3	6	4.0	Cc1ccc(OCC(F)(F)F)c(OCCN[C@@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809314	140534	None	0	Human	Functional	pIC50	=	6.3	6.3	8	2	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	507	13	3	6	4.0	Cc1ccc(OCC(F)(F)F)c(OCCN[C@@H](C)Cc2cc(C(N)=O)c3c(ccn3CCCO)c2)c1	10.1021/acs.jmedchem.5b02023
	16638286	149688	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3C1C2)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3946997	149688	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3C1C2)OCO4	10.1021/acs.jmedchem.6b01217
	10034371	166075	None	0	Rat	Functional	pIC50	=	5.3	5.3	-2	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CNCCCCCCNCCSSCCNCCCCCCNCc4ccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)cc4)cc3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL1203235	166075	None	0	Rat	Functional	pIC50	=	5.3	5.3	-2	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CNCCCCCCNCCSSCCNCCCCCCNCc4ccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)cc4)cc3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL425267	166075	None	0	Rat	Functional	pIC50	=	5.3	5.3	-2	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1277	47	6	20	10.9	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccc(CNCCCCCCNCCSSCCNCCCCCCNCc4ccc(C(=O)N(C)CCCCCCN(C)c5nc(N)c6cc(OC)c(OC)cc6n5)cc4)cc3)nc(N)c2cc1OC	10.1021/jm000995w
	10630100	96654	None	0	Rat	Functional	pIC50	=	5.3	5.3	1	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1161	33	6	20	7.3	COc1cc2nc(N3CCN(C(=O)c4ccccc4CNCCCCCCNCCSSCCNCCCCCCNCc4ccccc4C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)CC3)nc(N)c2cc1OC	10.1021/jm000995w
	CHEMBL263289	96654	None	0	Rat	Functional	pIC50	=	5.3	5.3	1	2	Antagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from ratAntagonist affinity [non competitive (irreversible)] at alpha-1A-adrenoceptors on isolated prostatic Vas deferens from rat	ChEMBL	1161	33	6	20	7.3	COc1cc2nc(N3CCN(C(=O)c4ccccc4CNCCCCCCNCCSSCCNCCCCCCNCc4ccccc4C(=O)N4CCN(c5nc(N)c6cc(OC)c(OC)cc6n5)CC4)CC3)nc(N)c2cc1OC	10.1021/jm000995w
	145947950	167835	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	440	7	0	3	5.8	Cc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1	10.1016/j.bmcl.2018.03.070
	CHEMBL4224703	167835	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	440	7	0	3	5.8	Cc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1	10.1016/j.bmcl.2018.03.070
	CHEMBL4302771	167835	None	0	Human	Functional	pIC50	=	6.3	6.3	1	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	440	7	0	3	5.8	Cc1cccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)c1	10.1016/j.bmcl.2018.03.070
	21171	187082	None	25	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL490533	187082	None	25	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1021/acs.jmedchem.6b01217
	142565322	197388	None	0	Human	Functional	pIC50	=	5.3	5.3	-426	5	Adrenoceptor reporter cell assay (ADRA1A)Adrenoceptor reporter cell assay (ADRA1A)	ChEMBL	391	6	2	6	2.4	CNc1cc[n+](CCNC(=O)c2ccn3c(-c4c(C)noc4C)cnc3c2)cc1	10.6019/CHEMBL5463728
	CHEMBL5395039	197388	None	0	Human	Functional	pIC50	=	5.3	5.3	-426	5	Adrenoceptor reporter cell assay (ADRA1A)Adrenoceptor reporter cell assay (ADRA1A)	ChEMBL	391	6	2	6	2.4	CNc1cc[n+](CCNC(=O)c2ccn3c(-c4c(C)noc4C)cnc3c2)cc1	10.6019/CHEMBL5463728
	CHEMBL5410211	197388	None	0	Human	Functional	pIC50	=	5.3	5.3	-426	5	Adrenoceptor reporter cell assay (ADRA1A)Adrenoceptor reporter cell assay (ADRA1A)	ChEMBL	391	6	2	6	2.4	CNc1cc[n+](CCNC(=O)c2ccn3c(-c4c(C)noc4C)cnc3c2)cc1	10.6019/CHEMBL5463728
	CHEMBL5498852	197388	None	0	Human	Functional	pIC50	=	5.3	5.3	-426	5	Adrenoceptor reporter cell assay (ADRA1A)Adrenoceptor reporter cell assay (ADRA1A)	ChEMBL	391	6	2	6	2.4	CNc1cc[n+](CCNC(=O)c2ccn3c(-c4c(C)noc4C)cnc3c2)cc1	10.6019/CHEMBL5463728
	21823379	144814	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	304	1	1	2	3.8	COc1ccc2c(c1)CCN1Cc3[nH]c4ccccc4c3CC21	10.1021/acs.jmedchem.6b01217
	CHEMBL3908813	144814	None	1	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	304	1	1	2	3.8	COc1ccc2c(c1)CCN1Cc3[nH]c4ccccc4c3CC21	10.1021/acs.jmedchem.6b01217
	4418	34231	None	58	Human	Functional	pIC50	=	6.3	6.3	-4	18	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1016/j.bmcl.2018.03.070
	4418.0	34231	None	58	Human	Functional	pIC50	=	6.3	6.3	-4	18	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1016/j.bmcl.2018.03.070
	CHEMBL142635	34231	None	58	Human	Functional	pIC50	=	6.3	6.3	-4	18	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1016/j.bmcl.2018.03.070
	DB12092	34231	None	58	Human	Functional	pIC50	=	6.3	6.3	-4	18	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1016/j.bmcl.2018.03.070
	145947047	167735	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	425	7	0	2	6.6	c1ccc(C2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	CHEMBL4227513	167735	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	425	7	0	2	6.6	c1ccc(C2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	CHEMBL4301557	167735	None	0	Human	Functional	pIC50	=	6.3	6.3	-1	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	425	7	0	2	6.6	c1ccc(C2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	123576734	140511	None	0	Human	Functional	pIC50	=	7.2	7.2	15	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	455	13	3	6	2.7	CCc1ccc(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(OC)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809032	140511	None	0	Human	Functional	pIC50	=	7.2	7.2	15	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	455	13	3	6	2.7	CCc1ccc(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(OC)c1	10.1021/acs.jmedchem.5b02023
	76071738	148417	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	318	0	1	3	3.6	c1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2[C@@H]1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3937032	148417	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	318	0	1	3	3.6	c1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2[C@@H]1C3)OCO4	10.1021/acs.jmedchem.6b01217
	145946630	167672	None	0	Human	Functional	pIC50	=	7.2	7.2	12	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	456	8	0	4	5.5	COc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	CHEMBL4224794	167672	None	0	Human	Functional	pIC50	=	7.2	7.2	12	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	456	8	0	4	5.5	COc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	CHEMBL4300618	167672	None	0	Human	Functional	pIC50	=	7.2	7.2	12	3	Antagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assayAntagonist activity at alpha 1A adrenergic receptor (unknown origin) by luciferase reporter gene assay	ChEMBL	456	8	0	4	5.5	COc1ccc(N2CCN(CCc3ccc(COc4ccc5c(c4)CCCC5)cc3)CC2)cc1	10.1016/j.bmcl.2018.03.070
	123752717	140557	None	0	Human	Functional	pIC50	=	7.2	7.2	26	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	439	11	3	5	3.1	Cc1cc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(C)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809500	140557	None	0	Human	Functional	pIC50	=	7.2	7.2	26	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	439	11	3	5	3.1	Cc1cc(C)c(OCCNC(C)Cc2cc3c(c(C(N)=O)c2)N(CCCO)CC3)c(C)c1	10.1021/acs.jmedchem.5b02023
	134145079	150310	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2C1C3)OCO4	10.1021/acs.jmedchem.6b01217
	CHEMBL3952204	150310	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	348	1	1	4	3.6	COc1ccc2c3c([nH]c2c1)CN1CCc2cc4c(cc2C1C3)OCO4	10.1021/acs.jmedchem.6b01217
	127044906	140505	None	0	Human	Functional	pIC50	=	7.2	7.2	7	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	529	13	3	6	3.7	C[C@@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	CHEMBL3808981	140505	None	0	Human	Functional	pIC50	=	7.2	7.2	7	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	529	13	3	6	3.7	C[C@@H](Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1cc(Cl)ccc1OCC(F)(F)F	10.1021/acs.jmedchem.5b02023
	123183788	140613	None	0	Human	Functional	pIC50	=	8.1	8.1	7	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	441	12	3	6	2.4	COc1cc(C)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3810220	140613	None	0	Human	Functional	pIC50	=	8.1	8.1	7	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	441	12	3	6	2.4	COc1cc(C)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	123378354	140474	None	0	Human	Functional	pIC50	=	7.2	7.2	6	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	493	11	3	5	3.0	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1Br	10.1021/acs.jmedchem.5b02023
	CHEMBL3808595	140474	None	0	Human	Functional	pIC50	=	7.2	7.2	6	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	493	11	3	5	3.0	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccc(F)cc1Br	10.1021/acs.jmedchem.5b02023
	145963961	164498	None	0	Human	Functional	pIC50	=	7.2	7.2	-32	6	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	CHEMBL4213342	164498	None	0	Human	Functional	pIC50	=	7.2	7.2	-32	6	Antagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assayAntagonistic activity at alpha-1A adrenergic receptor (unknown origin) after 10 mins by FLIPR assay	ChEMBL	425	8	1	7	3.0	CNC(=O)c1cc(OCCCCN2CCN(c3nsc4ccccc34)CC2)ccn1	10.1016/j.bmcl.2018.01.038
	134157568	154549	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	352	4	0	4	3.1	COc1cc2cc[n+]3c(c2cc1OC)Cc1ccc(OC)c(OC)c1C3	10.1021/acs.jmedchem.6b01217
	CHEMBL3984336	154549	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	352	4	0	4	3.1	COc1cc2cc[n+]3c(c2cc1OC)Cc1ccc(OC)c(OC)c1C3	10.1021/acs.jmedchem.6b01217
	CHEMBL3990197	154549	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	352	4	0	4	3.1	COc1cc2cc[n+]3c(c2cc1OC)Cc1ccc(OC)c(OC)c1C3	10.1021/acs.jmedchem.6b01217
	127044916	140569	None	0	Human	Functional	pIC50	=	8.1	8.1	1	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	443	12	3	6	2.9	COc1cc(F)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	CHEMBL3809676	140569	None	0	Human	Functional	pIC50	=	8.1	8.1	1	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	443	12	3	6	2.9	COc1cc(F)ccc1OCCNC(C)Cc1cc(C(N)=O)c2c(ccn2CCCO)c1	10.1021/acs.jmedchem.5b02023
	123437117	140456	None	0	Human	Functional	pIC50	=	8.1	8.1	23	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	461	12	3	6	2.8	COc1cc(Cl)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	CHEMBL3808417	140456	None	0	Human	Functional	pIC50	=	8.1	8.1	23	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	461	12	3	6	2.8	COc1cc(Cl)ccc1OCCNC(C)Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2	10.1021/acs.jmedchem.5b02023
	127045050	140480	None	0	Human	Functional	pIC50	=	8.1	8.1	-5	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	503	14	3	6	3.7	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCc1ccccc1	10.1021/acs.jmedchem.5b02023
	CHEMBL3808632	140480	None	0	Human	Functional	pIC50	=	8.1	8.1	-5	3	Antagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 minsAntagonist activity at human alpha-1A adrenergic receptor transfected in HEK293 cells assessed as reduction in agonist-induced calcium mobilization after 10 mins	ChEMBL	503	14	3	6	3.7	CC(Cc1cc2c(c(C(N)=O)c1)N(CCCO)CC2)NCCOc1ccccc1OCc1ccccc1	10.1021/acs.jmedchem.5b02023
	118167692	164304	None	12	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at alpha1A adrenergic receptor (unknown origin)Antagonist activity at alpha1A adrenergic receptor (unknown origin)	ChEMBL	521	7	1	7	3.0	Cn1cnc(-c2cnc(O[C@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C[C@H]3F)c(C(N)=O)c2)c1	10.1021/acs.jmedchem.8b00633
	CHEMBL4210892	164304	None	12	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at alpha1A adrenergic receptor (unknown origin)Antagonist activity at alpha1A adrenergic receptor (unknown origin)	ChEMBL	521	7	1	7	3.0	Cn1cnc(-c2cnc(O[C@H]3CCN(C(=O)Cc4ccc(OC(F)(F)F)cc4)C[C@H]3F)c(C(N)=O)c2)c1	10.1021/acs.jmedchem.8b00633
	134134752	144297	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	318	1	1	2	4.4	COc1ccc2c(c1)CCN1C(C)c3[nH]c4ccccc4c3CC21	10.1021/acs.jmedchem.6b01217
	CHEMBL3904395	144297	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assayAntagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assay	ChEMBL	318	1	1	2	4.4	COc1ccc2c(c1)CCN1C(C)c3[nH]c4ccccc4c3CC21	10.1021/acs.jmedchem.6b01217
	10813278	106996	None	0	Rabbit	Functional	pKd	=	10.7	10.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	446	8	1	6	3.5	Cc1ccc(N2CCN(CCCNc3ncccc3C(=O)N(C)C)CC2)c(-n2cccc2)c1	10.1021/jm970166j
	CHEMBL314880	106996	None	0	Rabbit	Functional	pKd	=	10.7	10.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	446	8	1	6	3.5	Cc1ccc(N2CCN(CCCNc3ncccc3C(=O)N(C)C)CC2)c(-n2cccc2)c1	10.1021/jm970166j
	10697270	106234	None	0	Rabbit	Functional	pKd	=	10	10.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	519	9	2	8	3.2	CNC(=O)c1cnc2c(c(C)nn2C)c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	CHEMBL313775	106234	None	0	Rabbit	Functional	pKd	=	10	10.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	519	9	2	8	3.2	CNC(=O)c1cnc2c(c(C)nn2C)c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	10552132	112851	None	0	Rabbit	Functional	pKd	=	10	10.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	465	9	1	6	3.3	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	CHEMBL330579	112851	None	0	Rabbit	Functional	pKd	=	10	10.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	465	9	1	6	3.3	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	13305910	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1182155	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL215421	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL3741808	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	13305910	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL1182155	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL215421	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL3741808	11840	None	0	Rat	Functional	pKd	=	10.0	10.0	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	10506159	111463	None	0	Rabbit	Functional	pKd	=	9.9	9.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	520	8	1	9	3.4	Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccc(F)cc4-c4ncco4)CC3)c12	10.1021/jm970166j
	CHEMBL327231	111463	None	0	Rabbit	Functional	pKd	=	9.9	9.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	520	8	1	9	3.4	Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccc(F)cc4-c4ncco4)CC3)c12	10.1021/jm970166j
	10693231	205219	None	0	Human	Functional	pKd	=	9.8	9.8	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	416	4	1	6	2.2	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C#N)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	CHEMBL62033	205219	None	0	Human	Functional	pKd	=	9.8	9.8	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	416	4	1	6	2.2	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C#N)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	129211	3749	None	48	Rabbit	Functional	pKd	=	9.8	9.8	-	14	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970166j
	129211.0	3749	None	48	Rabbit	Functional	pKd	=	9.8	9.8	-	14	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970166j
	2562	3749	None	48	Rabbit	Functional	pKd	=	9.8	9.8	-	14	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970166j
	488	3749	None	48	Rabbit	Functional	pKd	=	9.8	9.8	-	14	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970166j
	CHEMBL836	3749	None	48	Rabbit	Functional	pKd	=	9.8	9.8	-	14	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970166j
	DB00706	3749	None	48	Rabbit	Functional	pKd	=	9.8	9.8	-	14	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970166j
	10526964	209423	None	0	Rabbit	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	437	10	1	6	3.2	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC2CC2)CC1	10.1021/jm970166j
	CHEMBL91278	209423	None	0	Rabbit	Functional	pKd	=	9.8	9.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	437	10	1	6	3.2	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2OCC2CC2)CC1	10.1021/jm970166j
	10764021	209449	None	0	Rabbit	Functional	pKd	=	9.7	9.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	409	9	1	5	3.4	CCCc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL91400	209449	None	0	Rabbit	Functional	pKd	=	9.7	9.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	409	9	1	5	3.4	CCCc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	24897950	56368	None	0	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferens assessed as noradrenaline induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Wistar rat vas deferens assessed as noradrenaline induced contractions after 30 mins	ChEMBL	462	11	2	6	2.9	COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O	10.1016/j.ejmech.2010.09.042
	CHEMBL1630940	56368	None	0	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity at alpha1A adrenoceptor in Wistar rat vas deferens assessed as noradrenaline induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Wistar rat vas deferens assessed as noradrenaline induced contractions after 30 mins	ChEMBL	462	11	2	6	2.9	COc1ccc(C[C@@H](C)NCCOc2ccccc2OCC(F)(F)F)cc1S(N)(=O)=O	10.1016/j.ejmech.2010.09.042
	71462043	84602	None	0	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	379	8	1	6	3.2	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2153555	84602	None	0	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	379	8	1	6	3.2	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2220895	84602	None	0	Rat	Functional	pKd	=	9.6	9.6	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	379	8	1	6	3.2	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1	10.1016/j.ejmech.2012.09.049
	129211	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	129211.0	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	2562	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	488	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	CHEMBL836	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	DB00706	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	129211	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	129211.0	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	2562	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	488	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	CHEMBL836	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	DB00706	3749	None	48	Human	Functional	pKd	=	9.5	9.5	-1	14	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	499	4077	None	13	Rat	Functional	pKd	=	9.5	9.5	-	1	Antagonistic activity at ADRA1A in isolated rat prostatic vas deferensAntagonistic activity at ADRA1A in isolated rat prostatic vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1016/j.bmcl.2005.09.027
	5685	4077	None	13	Rat	Functional	pKd	=	9.5	9.5	-	1	Antagonistic activity at ADRA1A in isolated rat prostatic vas deferensAntagonistic activity at ADRA1A in isolated rat prostatic vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1016/j.bmcl.2005.09.027
	CHEMBL25554	4077	None	13	Rat	Functional	pKd	=	9.5	9.5	-	1	Antagonistic activity at ADRA1A in isolated rat prostatic vas deferensAntagonistic activity at ADRA1A in isolated rat prostatic vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1016/j.bmcl.2005.09.027
	499	4077	None	13	Rat	Functional	pKd	=	9.5	9.5	-	1	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm011066n
	5685	4077	None	13	Rat	Functional	pKd	=	9.5	9.5	-	1	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm011066n
	CHEMBL25554	4077	None	13	Rat	Functional	pKd	=	9.5	9.5	-	1	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm011066n
	10526831	111452	None	0	Rabbit	Functional	pKd	=	9.5	9.5	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	434	8	1	7	3.1	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ncco2)CC1	10.1021/jm970166j
	CHEMBL327168	111452	None	0	Rabbit	Functional	pKd	=	9.5	9.5	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	434	8	1	7	3.1	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ncco2)CC1	10.1021/jm970166j
	13305910	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostateActivity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1182155	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostateActivity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL215421	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostateActivity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL3741808	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostateActivity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	13305910	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL1182155	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL215421	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL3741808	11840	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	345	8	1	6	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2ccccc2O1	10.1016/j.ejmech.2012.09.049
	129211	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	129211.0	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	2562	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	488	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	CHEMBL836	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	DB00706	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm970364a
	129211	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	129211.0	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	2562	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	488	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	CHEMBL836	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	DB00706	3749	None	48	Rat	Functional	pKd	=	9.5	9.5	-	14	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1021/jm000541z
	44289437	169966	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor	ChEMBL	431	9	1	5	4.7	COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O	10.1021/jm011066n
	CHEMBL44403	169966	None	0	Rat	Functional	pKd	=	9.5	9.5	-	0	Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor	ChEMBL	431	9	1	5	4.7	COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O	10.1021/jm011066n
	10789770	100939	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	451	6	1	7	2.4	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)c(OC)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	CHEMBL293695	100939	None	0	Human	Functional	pKd	=	9.5	9.5	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	451	6	1	7	2.4	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)c(OC)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	10645210	208937	None	0	Rabbit	Functional	pKd	=	9.4	9.4	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	409	8	1	5	3.5	CC(C)c1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL88211	208937	None	0	Rabbit	Functional	pKd	=	9.4	9.4	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	409	8	1	5	3.5	CC(C)c1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	499	4077	None	13	Rat	Functional	pKd	=	9.4	9.4	-	1	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	5685	4077	None	13	Rat	Functional	pKd	=	9.4	9.4	-	1	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	CHEMBL25554	4077	None	13	Rat	Functional	pKd	=	9.4	9.4	-	1	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	499	4077	None	13	Rat	Functional	pKd	=	9.4	9.4	-	1	Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor )Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor )	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm021078o
	5685	4077	None	13	Rat	Functional	pKd	=	9.4	9.4	-	1	Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor )Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor )	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm021078o
	CHEMBL25554	4077	None	13	Rat	Functional	pKd	=	9.4	9.4	-	1	Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor )Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor )	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm021078o
	44289437	169966	None	0	Rat	Functional	pKd	=	9.4	9.4	-	0	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	ChEMBL	431	9	1	5	4.7	COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O	10.1021/jm011066n
	CHEMBL44403	169966	None	0	Rat	Functional	pKd	=	9.4	9.4	-	0	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	ChEMBL	431	9	1	5	4.7	COc1cccc(OC)c1OCCNCC1CC(c2ccccc2)c2ccccc2C1=O	10.1021/jm011066n
	10787790	106046	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	411	9	1	6	2.8	CCOc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL313157	106046	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	411	9	1	6	2.8	CCOc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10744240	107090	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	508	9	2	7	2.8	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C(N)=O)cccc23)CC1	10.1021/jm970166j
	CHEMBL315496	107090	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	508	9	2	7	2.8	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C(N)=O)cccc23)CC1	10.1021/jm970166j
	10763212	168299	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	394	9	1	6	3.3	COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)C2CC2)CC1	10.1021/jm970166j
	CHEMBL433348	168299	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	394	9	1	6	3.3	COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)C2CC2)CC1	10.1021/jm970166j
	9893282	208927	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	533	9	1	8	3.5	Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12	10.1021/jm970166j
	CHEMBL88160	208927	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	533	9	1	8	3.5	Cc1nn(C)c2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12	10.1021/jm970166j
	44323795	209066	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	410	8	1	5	3.3	COc1ccccc1N1CCN(CCCNc2cc(C)ccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL89030	209066	None	0	Rabbit	Functional	pKd	=	9.3	9.3	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	410	8	1	5	3.3	COc1ccccc1N1CCN(CCCNc2cc(C)ccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	499	4077	None	13	Rat	Functional	pKd	=	9.3	9.3	-	1	Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm011066n
	5685	4077	None	13	Rat	Functional	pKd	=	9.3	9.3	-	1	Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm011066n
	CHEMBL25554	4077	None	13	Rat	Functional	pKd	=	9.3	9.3	-	1	Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm011066n
	9824384	118851	None	0	Rat	Functional	pKd	=	9.2	9.2	-	0	Antagonist activity at alpha1A adrenergic receptor in Wistar rat prostatic rat vas deferens assessed as inhibition of noradrenaline-induced contraction preincubated for 30 mins followed by noradrenaline addition measured after 45 mins in presence of cocaine hydrochlorideAntagonist activity at alpha1A adrenergic receptor in Wistar rat prostatic rat vas deferens assessed as inhibition of noradrenaline-induced contraction preincubated for 30 mins followed by noradrenaline addition measured after 45 mins in presence of cocaine hydrochloride	ChEMBL	437	4	1	8	3.1	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC	10.1016/j.bmc.2018.05.023
	CHEMBL342062	118851	None	0	Rat	Functional	pKd	=	9.2	9.2	-	0	Antagonist activity at alpha1A adrenergic receptor in Wistar rat prostatic rat vas deferens assessed as inhibition of noradrenaline-induced contraction preincubated for 30 mins followed by noradrenaline addition measured after 45 mins in presence of cocaine hydrochlorideAntagonist activity at alpha1A adrenergic receptor in Wistar rat prostatic rat vas deferens assessed as inhibition of noradrenaline-induced contraction preincubated for 30 mins followed by noradrenaline addition measured after 45 mins in presence of cocaine hydrochloride	ChEMBL	437	4	1	8	3.1	COc1cc2nc(N3CCN(C(=O)c4ccco4)[C@@H]4CCCC[C@@H]43)nc(N)c2cc1OC	10.1016/j.bmc.2018.05.023
	10478121	170905	None	0	Human	Functional	pKd	=	9.2	9.2	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	435	6	0	7	3.1	COc1cc2ncn(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC	10.1021/jm000541z
	CHEMBL445325	170905	None	0	Human	Functional	pKd	=	9.2	9.2	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	435	6	0	7	3.1	COc1cc2ncn(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC	10.1021/jm000541z
	10743446	107127	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	483	8	1	8	2.8	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2nc(C)n3C)CC1	10.1021/jm970166j
	CHEMBL315785	107127	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	483	8	1	8	2.8	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2nc(C)n3C)CC1	10.1021/jm970166j
	10549680	112447	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	413	8	1	6	3.1	CSc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL329601	112447	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	413	8	1	6	3.1	CSc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10647512	209483	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	456	8	2	6	1.6	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3ccn[n+]2-3)CC1	10.1021/jm970166j
	CHEMBL91547	209483	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	456	8	2	6	1.6	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3ccn[n+]2-3)CC1	10.1021/jm970166j
	10621397	209550	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	407	8	1	5	3.3	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C2CC2)CC1	10.1021/jm970166j
	CHEMBL91951	209550	None	0	Rabbit	Functional	pKd	=	9.2	9.2	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	407	8	1	5	3.3	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C2CC2)CC1	10.1021/jm970166j
	499	4077	None	13	Rat	Functional	pKd	=	9.2	9.2	-	1	Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostateActivity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	5685	4077	None	13	Rat	Functional	pKd	=	9.2	9.2	-	1	Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostateActivity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	CHEMBL25554	4077	None	13	Rat	Functional	pKd	=	9.2	9.2	-	1	Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostateActivity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate	ChEMBL	345	8	1	6	2.5	COc1cccc(c1OCCNCC1COc2c(O1)cccc2)OC	10.1021/jm060358r
	10574245	111585	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	422	8	1	7	2.3	COc1ccccc1N1CCN(CCCNc2ncc(C#N)cc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL327872	111585	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	422	8	1	7	2.3	COc1ccccc1N1CCN(CCCNc2ncc(C#N)cc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10577066	112475	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	490	8	2	6	2.3	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3c(Cl)cn[n+]2-3)CC1	10.1021/jm970166j
	CHEMBL329773	112475	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	490	8	2	6	2.3	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)c[nH]c3c(Cl)cn[n+]2-3)CC1	10.1021/jm970166j
	10530686	209361	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	549	9	1	6	5.2	CN(C)C(=O)c1cnc2c(Cl)cccc2c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	CHEMBL90878	209361	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	549	9	1	6	5.2	CN(C)C(=O)c1cnc2c(Cl)cccc2c1NCCCN1CCN(c2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	11795906	209524	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	411	8	1	6	2.7	COc1cc(C)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL91785	209524	None	0	Rabbit	Functional	pKd	=	9.1	9.1	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	411	8	1	6	2.7	COc1cc(C)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	14423371	97507	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.	ChEMBL	441	11	1	8	3.6	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC	10.1021/jm9810654
	CHEMBL27013	97507	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.	ChEMBL	441	11	1	8	3.6	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC	10.1021/jm9810654
	71462043	84602	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	379	8	1	6	3.2	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2153555	84602	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	379	8	1	6	3.2	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2220895	84602	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	379	8	1	6	3.2	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(Cl)c2O1	10.1016/j.ejmech.2012.09.049
	14423371	97507	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonistic affinity against Alpha-1A adrenergic receptor was determined in isolated prostatic vas deferens tissue from ratAntagonistic affinity against Alpha-1A adrenergic receptor was determined in isolated prostatic vas deferens tissue from rat	ChEMBL	441	11	1	8	3.6	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC	10.1016/s0960-894x(98)00217-0
	CHEMBL27013	97507	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonistic affinity against Alpha-1A adrenergic receptor was determined in isolated prostatic vas deferens tissue from ratAntagonistic affinity against Alpha-1A adrenergic receptor was determined in isolated prostatic vas deferens tissue from rat	ChEMBL	441	11	1	8	3.6	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccco3)nc(N)c2cc1OC	10.1016/s0960-894x(98)00217-0
	10456471	100587	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	451	6	1	7	2.4	COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC	10.1021/jm000541z
	CHEMBL291303	100587	None	0	Human	Functional	pKd	=	9.0	9.0	-	0	In vitro antagonistic activity against alpha-1A receptor in dog prostate.In vitro antagonistic activity against alpha-1A receptor in dog prostate.	ChEMBL	451	6	1	7	2.4	COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC	10.1021/jm000541z
	10572854	112629	None	0	Rabbit	Functional	pKd	=	9	9.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	396	8	1	5	3.0	COc1ccccc1N1CCN(CCCNc2ccccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL330060	112629	None	0	Rabbit	Functional	pKd	=	9	9.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	396	8	1	5	3.0	COc1ccccc1N1CCN(CCCNc2ccccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10786203	209727	None	0	Rabbit	Functional	pKd	=	9	9.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	383	8	2	6	2.1	CNC(=O)c1cccnc1NCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm970166j
	CHEMBL93054	209727	None	0	Rabbit	Functional	pKd	=	9	9.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	383	8	2	6	2.1	CNC(=O)c1cccnc1NCCCN1CCN(c2ccccc2OC)CC1	10.1021/jm970166j
	11430491	63021	None	0	Rat	Functional	pKd	=	9	9.0	-	0	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	435	5	1	9	2.4	COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC	10.1021/jm049153d
	CHEMBL178673	63021	None	0	Rat	Functional	pKd	=	9	9.0	-	0	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	435	5	1	9	2.4	COc1cc2nc(N3CCN(C(=O)CC4CCSS4)CC3)nc(N)c2cc1OC	10.1021/jm049153d
	10527469	156356	None	2	Human	Functional	pKd	=	9	9.0	-	0	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
	CHEMBL40650	156356	None	2	Human	Functional	pKd	=	9	9.0	-	0	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostateIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in dog prostate	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
	4209	3163	None	48	Rat	Functional	pKd	=	9.0	9.0	-1	17	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm049153d
	4893	3163	None	48	Rat	Functional	pKd	=	9.0	9.0	-1	17	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm049153d
	4893.0	3163	None	48	Rat	Functional	pKd	=	9.0	9.0	-1	17	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm049153d
	503	3163	None	48	Rat	Functional	pKd	=	9.0	9.0	-1	17	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm049153d
	5385	3163	None	48	Rat	Functional	pKd	=	9.0	9.0	-1	17	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm049153d
	CHEMBL2	3163	None	48	Rat	Functional	pKd	=	9.0	9.0	-1	17	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm049153d
	DB00457	3163	None	48	Rat	Functional	pKd	=	9.0	9.0	-1	17	Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1021/jm049153d
	10478121	170905	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	435	6	0	7	3.1	COc1cc2ncn(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC	10.1021/jm000541z
	CHEMBL445325	170905	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	435	6	0	7	3.1	COc1cc2ncn(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC	10.1021/jm000541z
	16121006	11845	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL1182182	11845	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	CHEMBL217469	11845	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	365	7	1	5	3.7	COc1ccc2ccccc2c1OCCNC[C@H]1COc2ccccc2O1	10.1021/jm060358r
	11742834	165865	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor	ChEMBL	419	9	1	5	4.7	COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1	10.1021/jm011066n
	CHEMBL42472	165865	None	0	Rat	Functional	pKd	=	9.0	9.0	-	0	Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor	ChEMBL	419	9	1	5	4.7	COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1	10.1021/jm011066n
	10527469	156356	None	2	Rat	Functional	pKd	=	8.9	8.9	-	0	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
	CHEMBL40650	156356	None	2	Rat	Functional	pKd	=	8.9	8.9	-	0	In vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferensIn vitro antagonism against Alpha-1A adrenergic receptor using phenylephrine (PE) challenge in rat vas deferens	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
	10834793	84613	None	0	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	363	8	1	6	2.7	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2153557	84613	None	0	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	363	8	1	6	2.7	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2220925	84613	None	0	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostate assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	363	8	1	6	2.7	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(F)c2O1	10.1016/j.ejmech.2012.09.049
	132266	1278	None	10	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deferenceAntagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deference	ChEMBL	437	4	1	8	3.1	COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1	10.1021/jm8016046
	486	1278	None	10	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deferenceAntagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deference	ChEMBL	437	4	1	8	3.1	COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1	10.1021/jm8016046
	CHEMBL423294	1278	None	10	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deferenceAntagonist activity at rat alpha1A adrenoceptor assessed as inhibition if norepinephrine-induced contraction of vas deference	ChEMBL	437	4	1	8	3.1	COc1cc2nc(nc(c2cc1OC)N)N1CCN([C@@H]2[C@H]1CCCC2)C(=O)c1ccco1	10.1021/jm8016046
	10505222	209123	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	490	8	1	7	3.6	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C#N)cccc23)CC1	10.1021/jm970166j
	CHEMBL89397	209123	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	490	8	1	7	3.6	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c(C#N)cccc23)CC1	10.1021/jm970166j
	10575254	209341	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	443	8	1	5	4.1	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1021/jm970166j
	CHEMBL90746	209341	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	443	8	1	5	4.1	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2-c2ccccc2)CC1	10.1021/jm970166j
	10814587	209350	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	480	8	1	7	3.4	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3nc(C)ccc23)CC1	10.1021/jm970166j
	CHEMBL90810	209350	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	480	8	1	7	3.4	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3nc(C)ccc23)CC1	10.1021/jm970166j
	10646065	209360	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	425	8	2	6	3.2	COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)NC(C)(C)C)CC1	10.1021/jm970166j
	CHEMBL90874	209360	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	425	8	2	6	3.2	COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)NC(C)(C)C)CC1	10.1021/jm970166j
	10624682	209496	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	483	8	1	8	2.8	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2c(C)nn3C)CC1	10.1021/jm970166j
	CHEMBL91605	209496	None	0	Rabbit	Functional	pKd	=	8.9	8.9	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	483	8	1	8	2.8	COc1cc(F)ccc1N1CCN(CCCNc2c(C(=O)N(C)C)cnc3c2c(C)nn3C)CC1	10.1021/jm970166j
	10789770	100939	None	0	Rat	Functional	pKd	=	8.9	8.9	-	0	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	451	6	1	7	2.4	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)c(OC)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	CHEMBL293695	100939	None	0	Rat	Functional	pKd	=	8.9	8.9	-	0	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	451	6	1	7	2.4	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(OC)c(OC)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	11742834	165865	None	0	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	ChEMBL	419	9	1	5	4.7	COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1	10.1021/jm011066n
	CHEMBL42472	165865	None	0	Rat	Functional	pKd	=	8.9	8.9	-	0	Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptorAntagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor	ChEMBL	419	9	1	5	4.7	COc1cccc(OC)c1OCCNC[C@@H]1C[C@H](c2ccccc2)c2ccccc2O1	10.1021/jm011066n
	10693231	205219	None	0	Rat	Functional	pKd	=	8.8	8.8	-	0	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	416	4	1	6	2.2	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C#N)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	CHEMBL62033	205219	None	0	Rat	Functional	pKd	=	8.8	8.8	-	0	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferensIn vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	ChEMBL	416	4	1	6	2.2	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4cc(C#N)ccc4c3=O)C[C@@H]21	10.1021/jm000541z
	9865577	112372	None	2	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	397	8	1	6	2.4	COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL329160	112372	None	2	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	397	8	1	6	2.4	COc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10621790	163911	None	0	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	415	8	1	6	2.6	COc1cc(F)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL420620	163911	None	0	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	415	8	1	6	2.6	COc1cc(F)ccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10839699	209209	None	0	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	520	9	1	8	3.8	Cc1noc2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12	10.1021/jm970166j
	CHEMBL90022	209209	None	0	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	520	9	1	8	3.8	Cc1noc2ncc(C(=O)N(C)C)c(NCCCN3CCN(c4ccccc4OCC(F)(F)F)CC3)c12	10.1021/jm970166j
	10552164	209358	None	0	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	466	9	1	6	3.4	CN(C)C(=O)c1cccnc1N1CCC(NCCOc2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	CHEMBL90869	209358	None	0	Rabbit	Functional	pKd	=	8.8	8.8	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	466	9	1	6	3.4	CN(C)C(=O)c1cccnc1N1CCC(NCCOc2ccccc2OCC(F)(F)F)CC1	10.1021/jm970166j
	10549596	84639	None	1	Rat	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	375	9	1	7	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2153553	84639	None	1	Rat	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	375	9	1	7	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1	10.1016/j.ejmech.2012.09.049
	CHEMBL2221147	84639	None	1	Rat	Functional	pKd	=	8.8	8.8	-	0	Antagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 minsAntagonist activity at alpha1A adrenoceptor in Sprague-Dawley rat prostatic vas deferens assessed as inhibition of noradrenaline-induced contractions after 30 mins	ChEMBL	375	9	1	7	2.5	COc1cccc(OC)c1OCCNC[C@H]1COc2cccc(OC)c2O1	10.1016/j.ejmech.2012.09.049
	10501886	111464	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	413	8	2	7	2.1	COc1ccccc1N1CCN(CCCNc2ncc(O)cc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL327232	111464	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	413	8	2	7	2.1	COc1ccccc1N1CCN(CCCNc2ncc(O)cc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10693071	208932	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	413	8	0	5	3.7	COc1ccccc1N1CCN(CCCSc2ccccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL88181	208932	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	413	8	0	5	3.7	COc1ccccc1N1CCN(CCCSc2ccccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10833725	208969	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	381	7	1	5	2.7	Cc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	CHEMBL88435	208969	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	381	7	1	5	2.7	Cc1ccccc1N1CCN(CCCNc2ncccc2C(=O)N(C)C)CC1	10.1021/jm970166j
	10500734	209037	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	392	7	1	6	2.3	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C#N)CC1	10.1021/jm970166j
	CHEMBL88856	209037	None	0	Rabbit	Functional	pKd	=	8.7	8.7	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	392	7	1	6	2.3	CN(C)C(=O)c1cccnc1NCCCN1CCN(c2ccccc2C#N)CC1	10.1021/jm970166j
	44324012	209707	None	0	Rabbit	Functional	pKd	=	8	8.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	397	8	2	6	2.4	COc1ccccc1N1CCN(CCCNc2nc(C)cc(C)c2C(N)=O)CC1	10.1021/jm970166j
	CHEMBL92901	209707	None	0	Rabbit	Functional	pKd	=	8	8.0	-	0	Antagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assayAntagonistic activity against alpha 1A/1L receptor was assessed in a rabbit bladder neck functional assay	ChEMBL	397	8	2	6	2.4	COc1ccccc1N1CCN(CCCNc2nc(C)cc(C)c2C(N)=O)CC1	10.1021/jm970166j
	11994673	12320	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	419	7	1	5	4.5	COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3	10.1021/jm060358r
	CHEMBL1185036	12320	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	419	7	1	5	4.5	COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3	10.1021/jm060358r
	CHEMBL385371	12320	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferensActivity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens	ChEMBL	419	7	1	5	4.5	COc1ccc2ccccc2c1OCCNC[C@H]1COc2cc3c(cc2O1)CCCC3	10.1021/jm060358r
	10745791	36519	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.	ChEMBL	579	19	3	9	4.6	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCN)nc(N)c2cc1OC	10.1021/jm9810654
	CHEMBL144776	36519	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.Antagonism of the norepinephrine induced contraction of rat isolated prostatic vas deferens.	ChEMBL	579	19	3	9	4.6	COc1cc2nc(N(C)CCCCCCN(C)C(=O)c3ccccc3CNCCCCCCN)nc(N)c2cc1OC	10.1021/jm9810654
	10394346	16970	None	0	Rat	Functional	pKd	=	8.0	8.0	-	0	Functional Alpha-1A adrenergic receptor antagonistic activity of noradrenaline induced contractions in prostatic portion of rat vas deferensFunctional Alpha-1A adrenergic receptor antagonistic activity of noradrenaline induced contractions in prostatic portion of rat vas deferens	ChEMBL	638	11	2	10	3.0	Cc1c(-c2ccccc2)oc2c(C(=O)NCCCN3CCN(c4ccccc4OCc4no[n+]([O-])c4C(N)=O)CC3)cccc2c1=O	10.1021/jm030825u
	CHEMBL125365	16970	None	0	Rat

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Ligand source activities (1 row/activity)