Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL39 5ht2b_human Human Yes 10.2 EC50 = 0.1 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 9.3 EC50 = 0.5 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 9.1 EC50 = 0.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 9.1 EC50 = 0.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 9.1 EC50 = 0.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 9.0 EC50 = 0.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL350221 5ht2b_human Human Yes 9.0 EC50 = 1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O
CHEMBL39 5ht2b_human Human Yes 9.0 EC50 = 1.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 9.0 EC50 = 1.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL201930 5ht2b_human Human No 9.0 EC50 = 1.1 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 3 2.5 C[C@H](N)Cn1ccc2ccc3ncccc3c21
CHEMBL4460604 5ht2b_human Human No 8.9 EC50 = 1.3 nM Funct
Positive allosteric modulation of 5HT2B receptor (unknown origin) expressed in HEK293 cells co-expressing NFAT-RE assessed as increase in serotonin-induced reponse after 6 to 12 hrs by Bright-Glo luciferase reporter gene assayPositive allosteric modulation of 5HT2B receptor (unknown origin) expressed in HEK293 cells co-expressing NFAT-RE assessed as increase in serotonin-induced reponse after 6 to 12 hrs by Bright-Glo luciferase reporter gene assay
257 4 0 5 2.4 O=C(c1ccc(-n2cnc([N+](=O)[O-])c2)cc1)C1CC1
CHEMBL4533952 5ht2b_human Human No 8.9 EC50 = 1.3 nM Funct
Positive allosteric modulation of 5HT2B receptor (unknown origin) expressed in HEK293 cells co-expressing NFAT-RE assessed as increase in serotonin-induced reponse after 6 to 12 hrs by Bright-Glo luciferase reporter gene assayPositive allosteric modulation of 5HT2B receptor (unknown origin) expressed in HEK293 cells co-expressing NFAT-RE assessed as increase in serotonin-induced reponse after 6 to 12 hrs by Bright-Glo luciferase reporter gene assay
212 3 0 3 2.5 O=C(c1ccc(-n2ccnc2)cc1)C1CC1
CHEMBL350221 5ht2b_human Human Yes 8.9 EC50 = 1.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
220 3 4 3 0.8 N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O
CHEMBL39 5ht2b_human Human Yes 8.8 EC50 = 1.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 8.8 EC50 = 1.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 8.8 EC50 = 1.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 8.8 EC50 = 1.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 8.8 EC50 = 1.5 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 8.8 EC50 = 1.5 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL76781 5ht2b_human Human Yes 8.8 EC50 = 1.6 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL3928388 5ht2b_human Human No 8.7 EC50 = 2.0 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
240 0 1 2 2.2 Fc1ccc2c(c1Cl)N1CCNCC1CC2
CHEMBL2094028 5ht2b_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
165 2 1 1 1.8 NC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL2109749 5ht2b_human Human Yes 8.0 EC50 = 10 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
165 2 1 1 1.8 NC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL451543 5ht2b_human Human No 8.0 EC50 = 10 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
222 3 1 3 2.1 CSc1ccc2c(c1)N(C[C@H](C)N)CC2
CHEMBL376676 5ht2b_human Human No 7.0 EC50 = 100 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 2 2.2 C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12
CHEMBL3895972 5ht2b_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
250 0 1 2 2.7 CC1(C)Cc2cccc(Cl)c2N2CCNCC21
CHEMBL3938893 5ht2b_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
232 1 1 3 1.8 COc1cccc2c1N1CCCNC[C@H]1CC2
CHEMBL3961026 5ht2b_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
250 0 1 2 2.8 Clc1cccc2c1N1CCCNCCC1CC2
CHEMBL4776557 5ht2b_human Human No 7.0 EC50 = 100 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
230 2 1 2 2.4 CCCc1cccc2c1CC[C@@H]1CNCCN21
CHEMBL180815 5ht2b_human Human No 7.0 EC50 = 100 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
269 1 1 2 2.7 COc1cc2c(cc1Br)C(C)CNCC2
CHEMBL3891802 5ht2b_human Human No 6.0 EC50 = 1000 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
216 0 1 2 2.2 c1ccc2c(c1)CCC1CCNCCCN21
CHEMBL180668 5ht2b_human Human Yes 6.0 EC50 = 1000 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
181 0 1 1 2.0 Clc1ccc2c(c1)CCNCC2
CHEMBL181172 5ht2b_human Human Yes 6.0 EC50 = 1000 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
195 0 1 1 2.6 CC1CNCCc2ccc(Cl)cc21
CHEMBL3286565 5ht2b_human Human No 6.0 EC50 = 1000 nM Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
282 3 2 4 2.4 CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2
CHEMBL3770174 5ht2b_human Human No 6.0 EC50 = 1000 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771386 5ht2b_human Human No 6.0 EC50 = 1000 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL360328 5ht2b_human Human Yes 6.0 EC50 = 1000 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL179329 5ht2b_human Human No 6.0 EC50 = 1000 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
297 2 1 2 3.3 COc1cc2c(cc1Br)C(C(C)C)CNCC2
CHEMBL180668 5ht2b_human Human Yes 6.0 EC50 = 1000 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
181 0 1 1 2.0 Clc1ccc2c(c1)CCNCC2
CHEMBL3770174 5ht2b_human Human No 6.0 EC50 = 1001 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771386 5ht2b_human Human No 6.0 EC50 = 1001 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL2337106 5ht2b_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
284 1 2 2 2.1 CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21
CHEMBL2365079 5ht2b_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
284 1 2 2 2.1 CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21
CHEMBL590816 5ht2b_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
217 0 2 3 0.6 O=C1NC2CCNCCN2c2ccccc21
CHEMBL3770225 5ht2b_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3771396 5ht2b_human Human No 7.0 EC50 = 101 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3770225 5ht2b_human Human No 7.0 EC50 = 102.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL3771396 5ht2b_human Human No 7.0 EC50 = 102.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(F)c(Cl)c1C1CC1CN
CHEMBL511044 5ht2b_human Human No 7.0 EC50 = 103 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
280 4 2 3 1.1 O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2
CHEMBL4637882 5ht2b_human Human No 5.0 EC50 = 10600 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
220 0 1 2 2.0 CC1(C)CN2CCNCc3ccc(F)c1c32
CHEMBL209106 5ht2b_human Human Yes 7.0 EC50 = 108 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
206 1 1 2 1.6 Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1
CHEMBL2022192 5ht2b_human Human No 6.0 EC50 = 1080 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
253 5 1 2 3.3 NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1
CHEMBL2028036 5ht2b_human Human No 6.0 EC50 = 1080 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
253 5 1 2 3.3 NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1
CHEMBL4751981 5ht2b_human Human No 7.0 EC50 = 109.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802812 5ht2b_human Human No 7.0 EC50 = 109.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL39 5ht2b_human Human Yes 8.0 EC50 = 11 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL309760 5ht2b_human Human Yes 8.0 EC50 = 11 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
254 2 1 2 2.2 C[C@@H](CN1CCc2c1cc(Br)cc2)N
CHEMBL4567689 5ht2b_human Human No 7.9 EC50 = 11.8 nM Funct
Positive allosteric modulation of 5HT2B receptor (unknown origin) expressed in HEK293 cells co-expressing NFAT-RE assessed as increase in serotonin-induced reponse after 6 to 12 hrs by Bright-Glo luciferase reporter gene assayPositive allosteric modulation of 5HT2B receptor (unknown origin) expressed in HEK293 cells co-expressing NFAT-RE assessed as increase in serotonin-induced reponse after 6 to 12 hrs by Bright-Glo luciferase reporter gene assay
320 5 0 3 3.6 O=C(c1ccc(N2CCN(Cc3ccccc3)CC2)cc1)C1CC1
CHEMBL134519 5ht2b_rat Rat Yes 7.9 EC50 = 11.9 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
321 4 1 3 2.2 COc1cc(I)c(cc1C[C@H](N)C)OC
CHEMBL134519 5ht2b_rat Rat Yes 7.9 EC50 = 11.9 nM Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
321 4 1 3 2.2 COc1cc(I)c(cc1C[C@H](N)C)OC
CHEMBL181172 5ht2b_human Human Yes 6.0 EC50 = 1100 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
195 0 1 1 2.6 CC1CNCCc2ccc(Cl)cc21
CHEMBL4751981 5ht2b_human Human No 7.0 EC50 = 111 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802812 5ht2b_human Human No 7.0 EC50 = 111 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4116028 5ht2b_human Human No 7.0 EC50 = 112.2 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
341 9 1 3 4.3 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCC=C
CHEMBL4116028 5ht2b_human Human No 7.0 EC50 = 113 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
341 9 1 3 4.3 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCC=C
CHEMBL4515411 5ht2b_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
213 3 1 2 2.0 COc1ccc(F)cc1C1(F)CC1CN
CHEMBL4597225 5ht2b_human Human No 6.9 EC50 = 114.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
213 3 1 2 2.0 COc1ccc(F)cc1C1(F)CC1CN
CHEMBL4208452 5ht2b_human Human No 6.9 EC50 = 115 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
297 2 1 3 2.5 Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1
CHEMBL1643857 5ht2b_human Human No 5.9 EC50 = 1158 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 7 1.1 c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1
CHEMBL1186735 5ht2b_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 2 1 1 2.8 Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1
CHEMBL475641 5ht2b_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 2 1 1 2.8 Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1
CHEMBL1187556 5ht2b_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
213 2 1 1 2.9 Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F
CHEMBL508680 5ht2b_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
213 2 1 1 2.9 Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F
CHEMBL4515411 5ht2b_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
213 3 1 2 2.0 COc1ccc(F)cc1C1(F)CC1CN
CHEMBL4597225 5ht2b_human Human No 6.9 EC50 = 116 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
213 3 1 2 2.0 COc1ccc(F)cc1C1(F)CC1CN
CHEMBL197646 5ht2b_human Human Yes 5.9 EC50 = 1180 nM Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay
206 3 1 1 2.4 CN(C)CCc1c[nH]c2cccc(F)c12
CHEMBL1643858 5ht2b_human Human No 5.9 EC50 = 1184 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
406 4 1 7 1.7 CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1
CHEMBL1186737 5ht2b_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
175 2 1 1 2.4 Cc1ccc([C@H]2C[C@@H]2CN)cc1C
CHEMBL475643 5ht2b_human Human No 7.9 EC50 = 12 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
175 2 1 1 2.4 Cc1ccc([C@H]2C[C@@H]2CN)cc1C
CHEMBL2397896 5ht2b_human Human No 7.9 EC50 = 12 nM Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.0 Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2
CHEMBL1770378 5ht2b_human Human No 5.9 EC50 = 1200 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.1 Cc1ccccc1Cc1ncc2c(n1)CCNCC2
CHEMBL4637668 5ht2b_human Human No 5.9 EC50 = 1220 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
216 2 1 2 2.1 CCCc1ccc2c3c1CCN3CCNC2
CHEMBL4646572 5ht2b_human Human No 6.9 EC50 = 125 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
334 1 1 2 3.4 FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32
CHEMBL478 5ht2b_human Human Yes 6.9 EC50 = 125 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL492949 5ht2b_human Human No 6.9 EC50 = 125 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
254 2 1 3 0.6 CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2
CHEMBL478 5ht2b_human Human Yes 6.9 EC50 = 125 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL3955996 5ht2b_human Human No 6.9 EC50 = 125.9 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
206 0 1 2 1.6 Fc1ccc2c(c1)CCC1CNCCN21
CHEMBL3952329 5ht2b_human Human No 5.9 EC50 = 1258.9 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
232 1 1 3 1.8 COc1ccc2c(c1)CC[C@@H]1CNCCCN21
CHEMBL3978882 5ht2b_human Human No 5.9 EC50 = 1258.9 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
232 2 1 3 1.6 COCc1cccc2c1CCC1CNCCN21
CHEMBL4206126 5ht2b_human Human No 5.9 EC50 = 1258.9 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
285 2 1 3 2.3 FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL178365 5ht2b_human Human Yes 5.9 EC50 = 1258.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
195 0 1 1 2.6 C[C@@H]1CNCCc2ccc(Cl)cc21
CHEMBL181076 5ht2b_human Human Yes 5.9 EC50 = 1258.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.2 C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21
CHEMBL4759878 5ht2b_human Human No 6.9 EC50 = 128 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803107 5ht2b_human Human No 6.9 EC50 = 128 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL201117 5ht2b_human Human No 6.9 EC50 = 128 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
321 5 1 3 4.7 C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1
CHEMBL379223 5ht2b_human Human No 6.9 EC50 = 128 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
329 5 1 3 4.7 Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21
CHEMBL4759878 5ht2b_human Human No 6.9 EC50 = 128.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803107 5ht2b_human Human No 6.9 EC50 = 128.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4206126 5ht2b_human Human No 5.9 EC50 = 1290 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
285 2 1 3 2.3 FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL4218374 5ht2b_human Human No 5.9 EC50 = 1290 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
231 2 1 3 1.8 CCCc1cncc2c1CC[C@@H]1CNCCN21
CHEMBL1201087 5ht2b_human Human Yes 7.9 EC50 = 13 nM Funct
Agonist activity at human 5-HT2B receptor transfected in CHO cell assessed as IP1 production incubated for 30 mins measured by HTRF detection methodAgonist activity at human 5-HT2B receptor transfected in CHO cell assessed as IP1 production incubated for 30 mins measured by HTRF detection method
451 8 2 4 3.2 C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C
CHEMBL2323578 5ht2b_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5-HT2B receptor transfected in CHO cell assessed as IP1 production incubated for 30 mins measured by HTRF detection methodAgonist activity at human 5-HT2B receptor transfected in CHO cell assessed as IP1 production incubated for 30 mins measured by HTRF detection method
493 8 2 5 3.0 C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21
CHEMBL1186509 5ht2b_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccccc1Br
CHEMBL467736 5ht2b_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccccc1Br
CHEMBL1643677 5ht2b_human Human No 7.9 EC50 = 13 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 1.8 Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1
CHEMBL297784 5ht2b_human Human Yes 7.9 EC50 = 13 nM Funct
Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay
292 1 1 3 3.2 O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1
CHEMBL234837 5ht2b_rat Rat No 6.9 EC50 = 130 nM Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
315 4 1 6 1.7 Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1
CHEMBL179915 5ht2b_human Human No 6.9 EC50 = 130 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
259 1 1 2 3.0 COc1cc2c(cc1C(F)(F)F)C(C)CNCC2
CHEMBL2113264 5ht2b_human Human No 7.9 EC50 = 14 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
298 1 1 2 2.8 CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12
CHEMBL1186458 5ht2b_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl
CHEMBL464475 5ht2b_human Human No 7.9 EC50 = 14 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl
CHEMBL181787 5ht2b_human Human No 6.9 EC50 = 140 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
225 1 1 2 2.6 COc1cc2c(cc1Cl)C(C)CNCC2
CHEMBL178365 5ht2b_human Human Yes 5.9 EC50 = 1400 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
195 0 1 1 2.6 C[C@@H]1CNCCc2ccc(Cl)cc21
CHEMBL1187522 5ht2b_human Human No 6.9 EC50 = 141 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1cccc(Br)c1
CHEMBL506727 5ht2b_human Human No 6.9 EC50 = 141 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1cccc(Br)c1
CHEMBL577410 5ht2b_human Human No 6.9 EC50 = 142 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
339 3 1 5 1.9 O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2
CHEMBL1643856 5ht2b_human Human No 5.8 EC50 = 1478 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 7 1.1 c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1
CHEMBL3425755 5ht2b_human Human No 5.8 EC50 = 1484 nM Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
267 3 2 3 2.4 CNc1nc(Cc2ccccc2)cc2c1CCNCC2
CHEMBL3416056 5ht2b_human Human No 5.8 EC50 = 1485 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 3.0 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F
CHEMBL3546908 5ht2b_human Human No 5.8 EC50 = 1485 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 3.0 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F
CHEMBL492911 5ht2b_human Human No 7.8 EC50 = 15 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 3 2.3 O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2
CHEMBL4778104 5ht2b_human Human No 7.8 EC50 = 15.9 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
229 1 1 3 1.7 c1cc(C2CC2)c2c(n1)N1CCNC[C@H]1CC2
CHEMBL253811 5ht2b_human Human Yes 7.8 EC50 = 15.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
203 2 1 1 2.6 C[C@@H](Cc1cccc(c1)C(F)(F)F)N
CHEMBL4753812 5ht2b_human Human No 6.8 EC50 = 150 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802839 5ht2b_human Human No 6.8 EC50 = 150 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL440752 5ht2b_human Human Yes 5.8 EC50 = 1500 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
239 0 1 1 2.7 CC1CNCCc2ccc(Br)cc21
CHEMBL210215 5ht2b_human Human No 6.8 EC50 = 151 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
272 1 1 4 1.7 C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1
CHEMBL4753812 5ht2b_human Human No 6.8 EC50 = 151.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4802839 5ht2b_human Human No 6.8 EC50 = 151.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL202656 5ht2b_human Human No 6.8 EC50 = 152 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 3 2.5 C[C@H](N)Cn1ccc2ccc3cnccc3c21
CHEMBL3924644 5ht2b_human Human No 6.8 EC50 = 158.5 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
266 1 1 3 2.5 COc1cc2c(cc1Cl)N1CCCNC[C@H]1CC2
CHEMBL4213447 5ht2b_human Human No 6.8 EC50 = 158.5 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
257 2 1 3 2.1 c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2
CHEMBL178231 5ht2b_human Human Yes 5.8 EC50 = 1584.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.2 CC1CNCCc2ccc(Cl)c(Cl)c21
CHEMBL14022 5ht2b_human Human No 7.8 EC50 = 16 nM Funct
Agonist activity at human 5-HT2B receptor transfected in CHO cell assessed as IP1 production incubated for 30 mins measured by HTRF detection methodAgonist activity at human 5-HT2B receptor transfected in CHO cell assessed as IP1 production incubated for 30 mins measured by HTRF detection method
425 6 2 4 2.6 CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1
CHEMBL4639090 5ht2b_human Human No 6.8 EC50 = 160 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
266 0 1 2 2.5 CC1CN2CCNCc3ccc(Br)c1c32
CHEMBL1770385 5ht2b_human Human No 6.8 EC50 = 160 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
307 2 1 3 2.8 FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1
CHEMBL222566 5ht2b_human Human No 5.8 EC50 = 1610 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
282 1 1 2 2.4 C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21
CHEMBL1643678 5ht2b_human Human No 6.8 EC50 = 163 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
353 3 1 6 1.8 Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1
CHEMBL1770380 5ht2b_human Human No 6.8 EC50 = 164 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.1 Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL4213447 5ht2b_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
257 2 1 3 2.1 c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2
CHEMBL3769987 5ht2b_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771387 5ht2b_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL4647417 5ht2b_human Human No 5.8 EC50 = 1680 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
242 0 1 2 2.2 FC(F)(F)c1ccc2c3c1CCN3CCNC2
CHEMBL3416051 5ht2b_human Human No 5.8 EC50 = 1688 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.3 C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546894 5ht2b_human Human No 5.8 EC50 = 1688 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.3 C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL493951 5ht2b_human Human No 7.8 EC50 = 17 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
294 4 1 3 1.4 CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2
CHEMBL4759181 5ht2b_human Human No 6.8 EC50 = 173.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803103 5ht2b_human Human No 6.8 EC50 = 173.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL3769968 5ht2b_human Human No 5.8 EC50 = 1737.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771384 5ht2b_human Human No 5.8 EC50 = 1737.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL1186608 5ht2b_human Human No 5.8 EC50 = 1739 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 2 2 2.3 NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1
CHEMBL472678 5ht2b_human Human No 5.8 EC50 = 1739 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 2 2 2.3 NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1
CHEMBL4759181 5ht2b_human Human No 6.8 EC50 = 174 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803103 5ht2b_human Human No 6.8 EC50 = 174 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL3769968 5ht2b_human Human No 5.8 EC50 = 1745 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771384 5ht2b_human Human No 5.8 EC50 = 1745 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1cc(F)c(F)cc1C1CC1CN
CHEMBL220211 5ht2b_human Human No 6.8 EC50 = 175 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
286 1 1 3 1.8 COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21
CHEMBL4646618 5ht2b_human Human No 6.8 EC50 = 175 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
202 0 1 2 2.0 Cc1ccc2c3c1C(C)CN3CCNC2
CHEMBL4643574 5ht2b_human Human No 5.8 EC50 = 1750 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
202 1 1 2 1.7 CCc1ccc2c3c1CCN3CCNC2
CHEMBL1770381 5ht2b_human Human No 6.8 EC50 = 178 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
273 2 1 3 2.4 Clc1ccccc1Cc1ncc2c(n1)CCNCC2
CHEMBL3425756 5ht2b_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
281 4 2 3 2.8 CCNc1nc(Cc2ccccc2)cc2c1CCNCC2
CHEMBL449999 5ht2b_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 3 2.3 O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F
CHEMBL521805 5ht2b_human Human No 7.8 EC50 = 18 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
287 2 1 3 2.2 O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2
CHEMBL222514 5ht2b_human Human No 6.8 EC50 = 180 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 2 1.8 O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12
CHEMBL4757214 5ht2b_human Human No 6.8 EC50 = 180 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4803017 5ht2b_human Human No 6.8 EC50 = 180 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL360968 5ht2b_human Human No 6.8 EC50 = 180 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
283 2 1 2 3.1 CCOc1cc2c(cc1Br)C(C)CNCC2
CHEMBL178231 5ht2b_human Human Yes 5.8 EC50 = 1800 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 1 3.2 CC1CNCCc2ccc(Cl)c(Cl)c21
CHEMBL1770376 5ht2b_human Human No 6.7 EC50 = 183 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 3 1.9 Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1
CHEMBL1186108 5ht2b_human Human No 6.7 EC50 = 185 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
171 2 1 1 1.7 C#Cc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL450178 5ht2b_human Human No 6.7 EC50 = 185 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
171 2 1 1 1.7 C#Cc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL595195 5ht2b_human Human No 6.7 EC50 = 187 nM Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
329 3 1 4 3.2 Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21
CHEMBL572228 5ht2b_human Human No 6.7 EC50 = 187 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay
318 5 1 5 2.2 Clc1ccccc1CCOc1cncc(N2CCNCC2)n1
CHEMBL209155 5ht2b_human Human No 6.7 EC50 = 187 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
255 1 1 1 3.4 FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1
CHEMBL178313 5ht2b_human Human No 6.7 EC50 = 190 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
255 0 2 2 2.4 CC1CNCCc2cc(O)c(Br)cc21
CHEMBL4639115 5ht2b_human Human No 4.7 EC50 = 19000 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
204 1 1 3 1.2 COc1ccc2c3c1CCN3CCNC2
CHEMBL220274 5ht2b_human Human No 6.7 EC50 = 192 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 2 1.8 O=C1c2c(cccc2C(F)(F)F)C2CNCCN12
CHEMBL3770174 5ht2b_human Human No 5.7 EC50 = 1949.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771386 5ht2b_human Human No 5.7 EC50 = 1949.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3770174 5ht2b_human Human No 5.7 EC50 = 1957 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771386 5ht2b_human Human No 5.7 EC50 = 1957 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1 C=CCOc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL493151 5ht2b_human Human No 6.7 EC50 = 197 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
268 4 2 3 1.1 CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2
CHEMBL1186135 5ht2b_human Human No 6.7 EC50 = 199 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL451368 5ht2b_human Human No 6.7 EC50 = 199 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL3890492 5ht2b_human Human No 6.7 EC50 = 199.5 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
230 2 1 2 2.4 CCCc1ccc2c(c1)N1CCNCC1CC2
CHEMBL3947276 5ht2b_human Human No 6.7 EC50 = 199.5 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
230 2 1 2 2.4 CCCc1cccc2c1CCC1CNCCN21
CHEMBL4765074 5ht2b_human Human No 6.7 EC50 = 199.5 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
231 2 1 3 1.8 CCCc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL399750 5ht2b_human Human Yes 6.7 EC50 = 199.5 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
225 1 1 2 2.6 COc1cc2c(cc1Cl)CCNCC2C
CHEMBL3416061 5ht2b_human Human No 5.7 EC50 = 1994 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
223 5 1 2 2.7 CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN
CHEMBL3546956 5ht2b_human Human No 5.7 EC50 = 1994 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
223 5 1 2 2.7 CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN
CHEMBL3912721 5ht2b_human Human No 5.7 EC50 = 1995.3 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
256 2 1 2 2.8 c1cc(CC2CCC2)c2c(c1)N1CCNCC1CC2
CHEMBL440752 5ht2b_human Human Yes 5.7 EC50 = 1995.3 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
239 0 1 1 2.7 CC1CNCCc2ccc(Br)cc21
CHEMBL371300 5ht2b_rat Rat Yes 8.7 EC50 = 2 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
191 2 2 4 1.1 C[C@H](N)Cn1ncc2ccc(O)cc21
CHEMBL4466591 5ht2b_human Human No 8.7 EC50 = 2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@]1(F)c1cccc(F)c1
CHEMBL4597360 5ht2b_human Human No 8.7 EC50 = 2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@]1(F)c1cccc(F)c1
CHEMBL201454 5ht2b_human Human No 8.7 EC50 = 2.1 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
259 2 1 3 3.2 C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21
CHEMBL4466591 5ht2b_human Human No 8.6 EC50 = 2.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@]1(F)c1cccc(F)c1
CHEMBL4597360 5ht2b_human Human No 8.6 EC50 = 2.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@]1(F)c1cccc(F)c1
CHEMBL76781 5ht2b_human Human Yes 8.6 EC50 = 2.4 nM Funct
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL31115 5ht2b_rat Rat Yes 8.6 EC50 = 2.7 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
204 3 2 2 2.1 COc1ccc2[nH]cc(CC(C)N)c2c1
CHEMBL202458 5ht2b_human Human No 7.7 EC50 = 20 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
359 5 1 5 4.1 C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2
CHEMBL42 5ht2b_human Human Yes 7.7 EC50 = 20 nM Bind
Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL4636977 5ht2b_human Human No 6.7 EC50 = 200 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
280 0 1 2 2.7 CC1(C)CN2CCNCc3ccc(Br)c1c32
CHEMBL1186673 5ht2b_human Human No 6.7 EC50 = 204 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 2 2 2.3 NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO
CHEMBL474230 5ht2b_human Human No 6.7 EC50 = 204 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 2 2 2.3 NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO
CHEMBL376456 5ht2b_human Human No 6.7 EC50 = 207 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
218 1 1 3 0.8 COc1cccc2c1C(=O)N1CCNCC21
CHEMBL2337503 5ht2b_human Human No 6.7 EC50 = 207 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
216 0 2 2 1.1 Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365465 5ht2b_human Human No 6.7 EC50 = 207 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
216 0 2 2 1.1 Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL3770963 5ht2b_human Human No 6.7 EC50 = 208.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771381 5ht2b_human Human No 6.7 EC50 = 208.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3770963 5ht2b_human Human No 6.7 EC50 = 209 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771381 5ht2b_human Human No 6.7 EC50 = 209 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL1187196 5ht2b_human Human Yes 7.7 EC50 = 21 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
165 2 1 1 1.9 NC[C@H]1C[C@@H]1c1ccc(F)cc1
CHEMBL493130 5ht2b_human Human Yes 7.7 EC50 = 21 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
165 2 1 1 1.9 NC[C@H]1C[C@@H]1c1ccc(F)cc1
CHEMBL1201356 5ht2b_human Human Yes 7.7 EC50 = 21.4 nM Funct
Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay
339 4 3 3 1.9 CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO
CHEMBL4204710 5ht2b_human Human No 7.7 EC50 = 21.7 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
243 1 1 3 2.1 c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2
CHEMBL4516935 5ht2b_human Human No 7.7 EC50 = 21.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL4596490 5ht2b_human Human No 7.7 EC50 = 21.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL4638807 5ht2b_human Human No 5.7 EC50 = 2110 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
222 0 1 2 2.2 Clc1ccc2c3c1CCCN3CCNC2
CHEMBL4638879 5ht2b_human Human No 6.7 EC50 = 215 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
216 0 1 2 2.2 Cc1ccc2c3c1C(C)(C)CN3CCNC2
CHEMBL1643853 5ht2b_human Human No 6.7 EC50 = 215 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 7 1.7 COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1
CHEMBL4635854 5ht2b_human Human No 5.7 EC50 = 2150 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
252 0 1 2 1.9 Brc1ccc2c3c1CCN3CCNC2
CHEMBL1643675 5ht2b_human Human No 6.7 EC50 = 218 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
335 3 1 6 1.7 c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1
CHEMBL3770599 5ht2b_human Human No 5.7 EC50 = 2182 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL3771378 5ht2b_human Human No 5.7 EC50 = 2182 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL3770599 5ht2b_human Human No 5.7 EC50 = 2187.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL3771378 5ht2b_human Human No 5.7 EC50 = 2187.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1c(OCCF)ccc(F)c1F
CHEMBL360328 5ht2b_human Human Yes 6.7 EC50 = 219 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL219837 5ht2b_human Human No 7.7 EC50 = 22 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 2 2.2 C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12
CHEMBL1186133 5ht2b_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl
CHEMBL451232 5ht2b_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl
CHEMBL3425758 5ht2b_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
307 5 2 3 3.2 c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1
CHEMBL4516935 5ht2b_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL4596490 5ht2b_human Human No 7.7 EC50 = 22 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@]1(F)c1cccc(Cl)c1
CHEMBL76301 5ht2b_human Human No 7.7 EC50 = 22 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
320 2 1 2 2.1 C[C@H](N)CN1CCc2cc(F)c(I)cc21
CHEMBL1770375 5ht2b_human Human No 6.7 EC50 = 220 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 3 1.9 Fc1ccccc1Cc1ncc2c(n1)CCNCC2
CHEMBL180867 5ht2b_human Human No 6.7 EC50 = 220 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
269 1 1 2 2.7 COc1cc2c(cc1Br)[C@@H](C)CNCC2
CHEMBL3416047 5ht2b_human Human No 5.7 EC50 = 2211 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
237 5 1 2 3.0 C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546973 5ht2b_human Human No 5.7 EC50 = 2211 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
237 5 1 2 3.0 C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL1187565 5ht2b_human Human Yes 6.7 EC50 = 224 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@@H]1C[C@H]1c1ccccc1Br
CHEMBL509418 5ht2b_human Human Yes 6.7 EC50 = 224 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@@H]1C[C@H]1c1ccccc1Br
CHEMBL1643671 5ht2b_human Human No 5.7 EC50 = 2242 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
257 1 1 5 1.0 c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3
CHEMBL234682 5ht2b_rat Rat No 7.6 EC50 = 23 nM Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
311 4 1 6 3.4 Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1
CHEMBL203013 5ht2b_human Human No 7.6 EC50 = 23 nM Funct
Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR
273 4 1 4 1.7 C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12
CHEMBL415029 5ht2b_human Human No 6.6 EC50 = 230 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
297 2 1 2 3.5 CC(C)Oc1cc2c(cc1Br)C(C)CNCC2
CHEMBL3416032 5ht2b_human Human No 5.6 EC50 = 2307 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 4 1 2 2.8 CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546869 5ht2b_human Human No 5.6 EC50 = 2307 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 4 1 2 2.8 CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL2337499 5ht2b_human Human No 5.6 EC50 = 2330 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
250 1 2 2 1.7 CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365399 5ht2b_human Human No 5.6 EC50 = 2330 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
250 1 2 2 1.7 CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O
CHEMBL4457840 5ht2b_human Human Yes 5.6 EC50 = 2344.2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NCC1C(c2ccccc2)C1(F)F
CHEMBL4596163 5ht2b_human Human Yes 5.6 EC50 = 2344.2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NCC1C(c2ccccc2)C1(F)F
CHEMBL4457840 5ht2b_human Human Yes 5.6 EC50 = 2347 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NCC1C(c2ccccc2)C1(F)F
CHEMBL4596163 5ht2b_human Human Yes 5.6 EC50 = 2347 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
183 2 1 1 2.0 NCC1C(c2ccccc2)C1(F)F
CHEMBL2397911 5ht2b_human Human No 5.6 EC50 = 2366 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
244 1 1 2 1.5 CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O
CHEMBL4064809 5ht2b_human Human No 6.6 EC50 = 238 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL4116194 5ht2b_human Human No 6.6 EC50 = 238 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL4064809 5ht2b_human Human No 6.6 EC50 = 239.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL4116194 5ht2b_human Human No 6.6 EC50 = 239.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
310 6 1 3 3.6 COc1ccc(F)cc1C1CC1CNCc1ccccc1C#N
CHEMBL4117120 5ht2b_human Human No 7.6 EC50 = 24 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCCF
CHEMBL4117120 5ht2b_human Human No 7.6 EC50 = 24.6 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COC1=CC=CC=C1CNC[C@H]2C[C@@H]2C3=C(C=CC(=C3)F)OCCF
CHEMBL7257 5ht2b_rat Rat Yes 6.6 EC50 = 240 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
218 4 1 2 2.3 COc1ccc2c(c1)c(CCN(C)C)c[nH]2
CHEMBL3286564 5ht2b_human Human No 6.6 EC50 = 247 nM Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay
324 3 1 5 1.6 c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1
CHEMBL3770689 5ht2b_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771380 5ht2b_human Human No 7.6 EC50 = 25 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL39 5ht2b_human Human Yes 7.6 EC50 = 25.1 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL3770689 5ht2b_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771380 5ht2b_human Human No 7.6 EC50 = 25.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL253805 5ht2b_human Human No 6.6 EC50 = 251.2 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.2 C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21
CHEMBL253809 5ht2b_human Human Yes 6.6 EC50 = 251.2 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
209 1 1 1 3.0 CC[C@H]1CNCCc2ccc(Cl)cc21
CHEMBL3899449 5ht2b_human Human No 5.6 EC50 = 2511.9 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
264 1 1 2 3.1 c1ccc(-c2cccc3c2CCC2CNCCN32)cc1
CHEMBL3919795 5ht2b_human Human No 5.6 EC50 = 2511.9 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
278 2 1 2 3.0 c1ccc(Cc2cccc3c2CCC2CNCCN32)cc1
CHEMBL368016 5ht2b_human Human Yes 5.6 EC50 = 2511.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
213 0 1 1 2.7 CC1CNCCc2ccc(Cl)c(F)c21
CHEMBL3769421 5ht2b_human Human No 5.6 EC50 = 2511.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3771385 5ht2b_human Human No 5.6 EC50 = 2511.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3769421 5ht2b_human Human No 5.6 EC50 = 2521 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3771385 5ht2b_human Human No 5.6 EC50 = 2521 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL4802486 5ht2b_human Human No 6.6 EC50 = 257.0 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL4752412 5ht2b_human Human No 6.6 EC50 = 257.0 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4802814 5ht2b_human Human No 6.6 EC50 = 257.0 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4802486 5ht2b_human Human No 6.6 EC50 = 258 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 5 1 3 2.2 C=CCOC1=C(C2=C(C=C1)OCC2)[C@H]3C[C@@H]3CN
CHEMBL4752412 5ht2b_human Human No 6.6 EC50 = 258 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4802814 5ht2b_human Human No 6.6 EC50 = 258 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
247 5 1 3 2.5 CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4636494 5ht2b_human Human No 6.6 EC50 = 260 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
214 1 1 2 2.0 c1cc(C2CC2)c2c3c1CNCCN3CC2
CHEMBL585012 5ht2b_human Human No 6.6 EC50 = 267 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
289 2 1 4 1.6 O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2
CHEMBL2337488 5ht2b_human Human No 6.6 EC50 = 268 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
298 1 1 2 2.4 CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21
CHEMBL2364960 5ht2b_human Human No 6.6 EC50 = 268 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
298 1 1 2 2.4 CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21
CHEMBL4758641 5ht2b_human Human No 6.6 EC50 = 269 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL4803076 5ht2b_human Human No 6.6 EC50 = 269 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL4758641 5ht2b_human Human No 6.6 EC50 = 269.2 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL4803076 5ht2b_human Human No 6.6 EC50 = 269.2 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 2.5 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2
CHEMBL3425759 5ht2b_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
295 5 2 3 3.2 CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2
CHEMBL3425763 5ht2b_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
238 2 1 2 2.4 c1ccc(Cc2cc3c(cn2)CCNCC3)cc1
CHEMBL3770753 5ht2b_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771382 5ht2b_human Human No 7.6 EC50 = 27 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL202616 5ht2b_human Human No 7.6 EC50 = 27 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
365 5 1 3 5.5 C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1
CHEMBL3770753 5ht2b_human Human No 7.6 EC50 = 27.5 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771382 5ht2b_human Human No 7.6 EC50 = 27.5 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL594469 5ht2b_human Human No 5.6 EC50 = 2700 nM Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
345 4 1 4 3.0 Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1
CHEMBL2397888 5ht2b_human Human No 6.6 EC50 = 271 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.2 C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12
CHEMBL1187408 5ht2b_human Human No 5.6 EC50 = 2737 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Br)cc1
CHEMBL501854 5ht2b_human Human No 5.6 EC50 = 2737 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Br)cc1
CHEMBL223466 5ht2b_human Human No 6.6 EC50 = 274 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
250 1 1 2 2.0 CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O
CHEMBL4094164 5ht2b_human Human No 6.6 EC50 = 274 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
316 7 1 4 3.1 COc1ccc(F)cc1C1CC1CNCc1cccnc1OC
CHEMBL4094164 5ht2b_human Human No 6.6 EC50 = 275.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
316 7 1 4 3.1 COc1ccc(F)cc1C1CC1CNCc1cccnc1OC
CHEMBL4777303 5ht2b_human Human No 6.6 EC50 = 275.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4802306 5ht2b_human Human No 6.6 EC50 = 275.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4777303 5ht2b_human Human No 6.6 EC50 = 279 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4802306 5ht2b_human Human No 6.6 EC50 = 279 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL385577 5ht2b_human Human No 7.6 EC50 = 28 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
252 1 1 3 1.4 COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21
CHEMBL1187169 5ht2b_human Human No 7.6 EC50 = 28 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1
CHEMBL492306 5ht2b_human Human No 7.6 EC50 = 28 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1
CHEMBL2397897 5ht2b_human Human No 7.6 EC50 = 28 nM Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
230 1 1 2 1.2 CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2
CHEMBL4541617 5ht2b_human Human No 6.6 EC50 = 281.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL4597957 5ht2b_human Human No 6.6 EC50 = 281.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL374562 5ht2b_human Human No 6.6 EC50 = 282 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 2 2.1 Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21
CHEMBL1643672 5ht2b_human Human No 5.5 EC50 = 2848 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
271 1 1 5 1.4 c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3
CHEMBL4541617 5ht2b_human Human No 6.5 EC50 = 285 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL4597957 5ht2b_human Human No 6.5 EC50 = 285 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
333 7 1 3 3.8 COc1ccccc1CNCC1CC1(F)c1cc(F)ccc1OC
CHEMBL478 5ht2b_human Human Yes 6.5 EC50 = 287 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL478 5ht2b_human Human Yes 6.5 EC50 = 287 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL478 5ht2b_human Human Yes 6.5 EC50 = 287 nM Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL2023357 5ht2b_human Human No 6.5 EC50 = 289 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
235 5 1 2 2.7 NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1
CHEMBL2023357 5ht2b_human Human No 6.5 EC50 = 289 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization
235 5 1 2 2.7 NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1
CHEMBL223292 5ht2b_human Human No 6.5 EC50 = 290 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
236 0 1 2 1.7 Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O
CHEMBL375302 5ht2b_human Human No 6.5 EC50 = 293 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 2 2.6 CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12
CHEMBL375170 5ht2b_human Human No 5.5 EC50 = 2980 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
296 1 1 2 2.7 O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12
CHEMBL4100216 5ht2b_human Human No 8.5 EC50 = 3 nM Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
301 3 0 5 3.6 CCn1nc(-c2cccc3cccnc23)cc1-c1cccnn1
CHEMBL77880 5ht2b_human Human No 8.5 EC50 = 3 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
218 2 1 3 1.3 C[C@H](N)CN1CCc2ccc3c(c21)CCO3
CHEMBL407909 5ht2b_human Human Yes 8.5 EC50 = 3.2 nM Funct
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
243 3 1 4 2.7 CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C
CHEMBL39 5ht2b_rat Rat Yes 8.5 EC50 = 3.5 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL1187187 5ht2b_human Human Yes 8.4 EC50 = 3.6 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
165 2 1 1 1.9 NC[C@H]1C[C@@H]1c1cccc(F)c1
CHEMBL492926 5ht2b_human Human Yes 8.4 EC50 = 3.6 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
165 2 1 1 1.9 NC[C@H]1C[C@@H]1c1cccc(F)c1
CHEMBL1224034 5ht2b_human Human No 8.4 EC50 = 4.0 nM Funct
Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay
336 1 1 3 3.9 O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21
CHEMBL1770382 5ht2b_human Human No 7.5 EC50 = 30 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
273 2 1 3 2.4 Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1
CHEMBL3425762 5ht2b_human Human No 7.5 EC50 = 30 nM Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
281 3 1 3 2.4 CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2
CHEMBL3769454 5ht2b_human Human No 7.5 EC50 = 30 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2b_human Human No 7.5 EC50 = 30 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL182184 5ht2b_human Human No 7.5 EC50 = 30 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
269 1 1 2 2.7 COc1cc2c(cc1Br)[C@H](C)CNCC2
CHEMBL3769454 5ht2b_human Human No 7.5 EC50 = 30.2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2b_human Human No 7.5 EC50 = 30.2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3769543 5ht2b_human Human No 7.5 EC50 = 30.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL3771390 5ht2b_human Human No 7.5 EC50 = 30.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL609306 5ht2b_human Human No 6.5 EC50 = 300 nM Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
329 3 1 4 3.2 Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21
CHEMBL4644872 5ht2b_human Human No 6.5 EC50 = 300 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
236 0 1 2 2.7 Cc1cc2c3c(c1Cl)C(C)CN3CCNC2
CHEMBL3416034 5ht2b_human Human No 5.5 EC50 = 3004 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546890 5ht2b_human Human No 5.5 EC50 = 3004 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3416040 5ht2b_human Human No 5.5 EC50 = 3034 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL3546903 5ht2b_human Human No 5.5 EC50 = 3034 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL2022186 5ht2b_human Human No 6.5 EC50 = 304 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
205 5 1 2 2.5 CCCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL2027987 5ht2b_human Human No 6.5 EC50 = 304 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
205 5 1 2 2.5 CCCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL4212834 5ht2b_human Human No 6.5 EC50 = 307 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
297 2 1 3 2.5 Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1
CHEMBL4740346 5ht2b_human Human No 6.5 EC50 = 309 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL4802388 5ht2b_human Human No 6.5 EC50 = 309 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL4740346 5ht2b_human Human No 6.5 EC50 = 309.0 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL4802388 5ht2b_human Human No 6.5 EC50 = 309.0 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
259 5 1 3 3.5 CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN
CHEMBL1186092 5ht2b_human Human Yes 5.5 EC50 = 3092 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NC[C@@H]1C[C@H]1c1ccccc1
CHEMBL449134 5ht2b_human Human Yes 5.5 EC50 = 3092 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NC[C@@H]1C[C@H]1c1ccccc1
CHEMBL2337493 5ht2b_human Human No 7.5 EC50 = 31 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
222 0 2 2 1.1 O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21
CHEMBL2365469 5ht2b_human Human No 7.5 EC50 = 31 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
222 0 2 2 1.1 O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21
CHEMBL3769543 5ht2b_human Human No 7.5 EC50 = 31 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL3771390 5ht2b_human Human No 7.5 EC50 = 31 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL80731 5ht2b_human Human No 7.5 EC50 = 31 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
254 4 1 3 2.6 CCSc1cc2c(cc1F)CCN2C[C@H](C)N
CHEMBL3930174 5ht2b_human Human Yes 7.5 EC50 = 31.6 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
202 0 1 2 1.7 Cc1cccc2c1CCC1CNCCN21
CHEMBL3967107 5ht2b_human Human No 7.5 EC50 = 31.6 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
206 0 1 2 1.6 Fc1ccc2c(c1)N1CCNCC1CC2
CHEMBL4777852 5ht2b_human Human No 6.5 EC50 = 316.2 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
245 2 1 3 2.0 CC(C)Cc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL360492 5ht2b_human Human No 6.5 EC50 = 316.2 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
213 0 1 1 2.7 CC1CNCCc2cc(F)c(Cl)cc21
CHEMBL4757718 5ht2b_human Human No 5.5 EC50 = 3162.3 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
284 2 1 2 2.9 FC(F)(F)CCc1cccc2c1CC[C@@H]1CNCCN21
CHEMBL2337492 5ht2b_human Human No 7.5 EC50 = 32 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
270 0 1 2 1.8 CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21
CHEMBL2365703 5ht2b_human Human No 7.5 EC50 = 32 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
270 0 1 2 1.8 CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21
CHEMBL1185954 5ht2b_human Human No 7.5 EC50 = 32 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1ccccc1Cl
CHEMBL443128 5ht2b_human Human No 7.5 EC50 = 32 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1ccccc1Cl
CHEMBL4635105 5ht2b_human Human No 6.5 EC50 = 320 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
236 0 1 2 2.5 CC1(C)CN2CCNCc3ccc(Cl)c1c32
CHEMBL4639054 5ht2b_human Human No 6.5 EC50 = 320 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
230 2 1 2 2.4 CC(C)Cc1ccc2c3c1CCN3CCNC2
CHEMBL208936 5ht2b_human Human No 6.5 EC50 = 320 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
258 1 1 4 1.3 FC(F)(F)c1ccnc(N2CCC3CNCC32)n1
CHEMBL4634942 5ht2b_human Human No 6.5 EC50 = 325 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
222 0 1 2 2.4 CC1CN2CCNCc3ccc(Cl)c1c32
CHEMBL360328 5ht2b_human Human Yes 6.5 EC50 = 328 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL3770689 5ht2b_human Human No 6.5 EC50 = 329 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771380 5ht2b_human Human No 6.5 EC50 = 329 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL374436 5ht2b_human Human No 7.5 EC50 = 33 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.4 CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21
CHEMBL3425760 5ht2b_human Human No 7.5 EC50 = 33 nM Funct
Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay
295 4 2 3 3.2 CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2
CHEMBL492910 5ht2b_human Human No 7.5 EC50 = 33 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
305 2 1 3 2.3 O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2
CHEMBL2022185 5ht2b_human Human No 6.5 EC50 = 331 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
191 4 1 2 2.1 CCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL2027895 5ht2b_human Human No 6.5 EC50 = 331 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay
191 4 1 2 2.1 CCOc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL4094054 5ht2b_human Human No 6.5 EC50 = 331.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
328 7 2 3 2.8 COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O
CHEMBL4117988 5ht2b_human Human No 6.5 EC50 = 331.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
328 7 2 3 2.8 COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O
CHEMBL3770689 5ht2b_human Human No 6.5 EC50 = 331.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3771380 5ht2b_human Human No 6.5 EC50 = 331.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1cc(F)c(Cl)cc1C1CC1CN
CHEMBL3769499 5ht2b_human Human No 5.5 EC50 = 3311.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771379 5ht2b_human Human No 5.5 EC50 = 3311.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3769499 5ht2b_human Human No 5.5 EC50 = 3339 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771379 5ht2b_human Human No 5.5 EC50 = 3339 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL1187322 5ht2b_human Human No 5.5 EC50 = 3342 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1c(F)cccc1F
CHEMBL498863 5ht2b_human Human No 5.5 EC50 = 3342 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1c(F)cccc1F
CHEMBL4094054 5ht2b_human Human No 6.5 EC50 = 335 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
328 7 2 3 2.8 COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O
CHEMBL4117988 5ht2b_human Human No 6.5 EC50 = 335 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
328 7 2 3 2.8 COc1ccc(F)cc1C1CC1CNCc1ccccc1C(N)=O
CHEMBL4757214 5ht2b_human Human No 6.5 EC50 = 338.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4803017 5ht2b_human Human No 6.5 EC50 = 338.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL455039 5ht2b_human Human No 7.5 EC50 = 34 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
294 2 1 3 1.5 O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1
CHEMBL4639970 5ht2b_human Human No 5.5 EC50 = 3400 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
256 1 1 2 2.6 FC(F)(F)CC1CN2CCNCc3cccc1c32
CHEMBL3416035 5ht2b_human Human No 5.5 EC50 = 3436 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546870 5ht2b_human Human No 5.5 EC50 = 3436 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 3.2 CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL4803813 5ht2b_human Human No 6.5 EC50 = 346.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
243 5 1 3 3.1 C=CCOC1=C(C2=C(C=C1)OC=C2)[C@H]3C[C@@H]3CN
CHEMBL4803813 5ht2b_human Human No 6.5 EC50 = 348 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
243 5 1 3 3.1 C=CCOC1=C(C2=C(C=C1)OC=C2)[C@H]3C[C@@H]3CN
CHEMBL1187186 5ht2b_human Human No 6.5 EC50 = 350 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 2.8 NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F
CHEMBL492917 5ht2b_human Human No 6.5 EC50 = 350 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 2.8 NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F
CHEMBL577903 5ht2b_human Human No 6.5 EC50 = 353 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
243 3 2 3 1.7 c1ccc(COc2n[nH]c3c2CCNCC3)cc1
CHEMBL3769987 5ht2b_human Human No 6.5 EC50 = 354 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771387 5ht2b_human Human No 6.5 EC50 = 354 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3769987 5ht2b_human Human No 6.5 EC50 = 354.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771387 5ht2b_human Human No 6.5 EC50 = 354.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL522514 5ht2b_human Human No 6.5 EC50 = 357 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
280 2 1 3 1.2 O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1
CHEMBL524778 5ht2b_human Human No 6.5 EC50 = 358 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
255 2 1 4 1.0 O=c1cc2c(nn1Cc1ccccc1)CCNCC2
CHEMBL80482 5ht2b_human Human No 7.4 EC50 = 36 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
232 2 1 3 1.7 C[C@H](N)CN1CCc2ccc3c(c21)CCCO3
CHEMBL524778 5ht2b_human Human No 6.4 EC50 = 360 nM Funct
Agonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
255 2 1 4 1.0 O=c1cc2c(nn1Cc1ccccc1)CCNCC2
CHEMBL360492 5ht2b_human Human No 6.4 EC50 = 360 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
213 0 1 1 2.7 CC1CNCCc2cc(F)c(Cl)cc21
CHEMBL4575163 5ht2b_human Human No 6.4 EC50 = 363 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
285 6 1 2 3.7 COc1ccccc1CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL4594655 5ht2b_human Human No 6.4 EC50 = 363 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
285 6 1 2 3.7 COc1ccccc1CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL4575163 5ht2b_human Human No 6.4 EC50 = 363.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
285 6 1 2 3.7 COc1ccccc1CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL4594655 5ht2b_human Human No 6.4 EC50 = 363.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
285 6 1 2 3.7 COc1ccccc1CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL1187168 5ht2b_human Human No 6.4 EC50 = 366 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1cccc(F)c1F
CHEMBL492305 5ht2b_human Human No 6.4 EC50 = 366 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1cccc(F)c1F
CHEMBL2397887 5ht2b_human Human No 7.4 EC50 = 37 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
216 0 1 2 1.0 C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12
CHEMBL1186169 5ht2b_human Human Yes 7.4 EC50 = 37 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NC[C@H]1C[C@@H]1c1ccccc1
CHEMBL452719 5ht2b_human Human Yes 7.4 EC50 = 37 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NC[C@H]1C[C@@H]1c1ccccc1
CHEMBL1186590 5ht2b_human Human No 7.4 EC50 = 37 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccc([C@H]2C[C@@H]2CN)cc1
CHEMBL471202 5ht2b_human Human No 7.4 EC50 = 37 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccc([C@H]2C[C@@H]2CN)cc1
CHEMBL1643679 5ht2b_human Human No 6.4 EC50 = 379 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 7 1.7 COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1
CHEMBL178124 5ht2b_human Human No 6.4 EC50 = 380 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 1 3.0 CC1CNCCc2ccc(C(F)(F)F)cc21
CHEMBL478 5ht2b_human Human Yes 7.4 EC50 = 39.8 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL3982618 5ht2b_human Human No 7.4 EC50 = 39.8 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
242 1 1 2 2.7 c1cc(C2CCC2)c2c(c1)N1CCNCC1CC2
CHEMBL4747291 5ht2b_human Human No 7.4 EC50 = 39.8 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
203 0 1 3 1.1 Cc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL478 5ht2b_human Human Yes 7.4 EC50 = 39.8 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
196 1 1 2 1.8 Clc1cccc(c1)N1CCNCC1
CHEMBL253591 5ht2b_human Human No 7.4 EC50 = 39.8 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.2 C[C@H]1CNCCc2cc(Cl)c(Cl)cc21
CHEMBL400600 5ht2b_human Human No 7.4 EC50 = 39.8 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
225 1 1 2 2.6 COc1cc2c(cc1Cl)[C@H](C)CNCC2
CHEMBL4634836 5ht2b_human Human No 6.4 EC50 = 391 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
240 0 1 3 2.4 Clc1ccc2c3c1SCCN3CCNC2
CHEMBL595194 5ht2b_human Human No 6.4 EC50 = 397 nM Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
343 3 1 4 3.6 Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21
CHEMBL3947432 5ht2b_human Human No 6.4 EC50 = 398.1 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
232 1 1 3 1.8 COc1cccc2c1CC[C@@H]1CNCCCN21
CHEMBL3959570 5ht2b_human Human No 6.4 EC50 = 398.1 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
284 2 1 3 3.1 c1csc(Cc2cccc3c2CCC2CNCCN32)c1
CHEMBL253806 5ht2b_human Human No 6.4 EC50 = 398.1 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
225 1 1 2 2.6 COc1cc2c(cc1Cl)[C@@H](C)CNCC2
CHEMBL3770753 5ht2b_human Human No 6.4 EC50 = 398.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771382 5ht2b_human Human No 6.4 EC50 = 398.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL3935339 5ht2b_human Human No 5.4 EC50 = 3981.1 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
322 2 1 4 2.7 c1cc(Cc2ccc3c(c2)OCO3)c2c(c1)N1CCNCC1CC2
CHEMBL367796 5ht2b_human Human Yes 5.4 EC50 = 3981.1 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
161 0 1 1 1.9 CC1CNCCc2ccccc21
CHEMBL76474 5ht2b_human Human No 8.4 EC50 = 4.1 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
240 3 1 3 2.3 CSc1cc2c(cc1F)CCN2C[C@H](C)N
CHEMBL39 5ht2b_rat Rat Yes 8.4 EC50 = 4.2 nM Bind
Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL275854 5ht2b_rat Rat Yes 8.4 EC50 = 4.2 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
190 2 3 2 1.8 CC(Cc1c[nH]c2c1cc(O)cc2)N
CHEMBL199775 5ht2b_rat Rat Yes 8.4 EC50 = 4.2 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
205 3 1 4 1.4 COc1ccc2cnn(C[C@H](C)N)c2c1
CHEMBL76781 5ht2b_human Human Yes 8.4 EC50 = 4.3 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL76781 5ht2b_human Human Yes 8.4 EC50 = 4.3 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
226 2 1 2 2.8 C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N
CHEMBL39 5ht2b_human Human Yes 8.4 EC50 = 4.5 nM Funct
Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht2b_human Human Yes 8.4 EC50 = 4.5 nM Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL1187185 5ht2b_human Human Yes 8.3 EC50 = 4.8 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NCC1CC1c1ccccc1Br
CHEMBL492916 5ht2b_human Human Yes 8.3 EC50 = 4.8 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 2 1 1 2.5 NCC1CC1c1ccccc1Br
CHEMBL1186686 5ht2b_human Human No 8.3 EC50 = 4.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
179 2 1 1 2.2 Cc1cc([C@H]2C[C@@H]2CN)ccc1F
CHEMBL474633 5ht2b_human Human No 8.3 EC50 = 4.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
179 2 1 1 2.2 Cc1cc([C@H]2C[C@@H]2CN)ccc1F
CHEMBL223272 5ht2b_human Human No 7.4 EC50 = 40 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 1 2 2.2 C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12
CHEMBL471839 5ht2b_human Human Yes 7.4 EC50 = 40 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells by [3H]-inositol phosphate accumulation assay
185 2 1 1 2.7 CC(N)Cc1ccc2ccccc2c1
CHEMBL426235 5ht2b_human Human No 7.4 EC50 = 40 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
283 2 1 2 3.1 CCC1CNCCc2cc(OC)c(Br)cc21
CHEMBL3770753 5ht2b_human Human No 6.4 EC50 = 400 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL3771382 5ht2b_human Human No 6.4 EC50 = 400 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1cc(F)c(F)cc1C1CC1CN
CHEMBL180166 5ht2b_human Human No 6.4 EC50 = 400 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
255 1 1 2 2.1 COc1cc2c(cc1Br)CCNCC2
CHEMBL4209052 5ht2b_human Human No 5.4 EC50 = 4020 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
257 2 1 3 2.1 c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2
CHEMBL1093699 5ht2b_human Human No 5.4 EC50 = 4027 nM Funct
Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor
364 7 2 4 3.2 COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1
CHEMBL1186561 5ht2b_human Human No 6.4 EC50 = 404 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1
CHEMBL469729 5ht2b_human Human No 6.4 EC50 = 404 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1
CHEMBL1770379 5ht2b_human Human No 6.4 EC50 = 410 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
253 2 1 3 2.1 Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1
CHEMBL4571641 5ht2b_human Human No 6.4 EC50 = 410 nM Funct
Agonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
273 2 1 3 2.4 Clc1ccc(Cc2cc3c(nn2)CCNCC3)cc1
CHEMBL2337500 5ht2b_human Human No 6.4 EC50 = 414 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.8 O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21
CHEMBL2365705 5ht2b_human Human No 6.4 EC50 = 414 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.8 O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21
CHEMBL1186595 5ht2b_human Human No 6.4 EC50 = 415 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1ccc(F)cc1F
CHEMBL471802 5ht2b_human Human No 6.4 EC50 = 415 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
183 2 1 1 2.0 NC[C@H]1C[C@@H]1c1ccc(F)cc1F
CHEMBL375642 5ht2b_human Human No 6.4 EC50 = 417 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
270 0 0 2 2.1 CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1
CHEMBL3416053 5ht2b_human Human No 6.4 EC50 = 422 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.4 C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546905 5ht2b_human Human No 6.4 EC50 = 422 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.4 C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3416046 5ht2b_human Human No 5.4 EC50 = 4295 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
237 5 1 2 3.0 C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546955 5ht2b_human Human No 5.4 EC50 = 4295 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
237 5 1 2 3.0 C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL360328 5ht2b_human Human Yes 6.4 EC50 = 433 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL360328 5ht2b_human Human Yes 6.4 EC50 = 433 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL4803350 5ht2b_human Human No 6.4 EC50 = 433 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
271 6 1 3 3.6 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCC=C
CHEMBL360328 5ht2b_human Human Yes 6.4 EC50 = 436.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL360328 5ht2b_human Human Yes 6.4 EC50 = 436.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL4803350 5ht2b_human Human No 6.4 EC50 = 436.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
271 6 1 3 3.6 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCC=C
CHEMBL202538 5ht2b_human Human No 7.4 EC50 = 44 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
349 5 1 3 5.0 C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl
CHEMBL3416048 5ht2b_human Human No 5.4 EC50 = 4411 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
235 4 1 2 2.4 C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546974 5ht2b_human Human No 5.4 EC50 = 4411 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
235 4 1 2 2.4 C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL4762225 5ht2b_human Human No 6.4 EC50 = 446.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12
CHEMBL4803142 5ht2b_human Human No 6.4 EC50 = 446.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12
CHEMBL3769499 5ht2b_human Human No 5.4 EC50 = 4464 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771379 5ht2b_human Human No 5.4 EC50 = 4464 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3769499 5ht2b_human Human No 5.4 EC50 = 4466.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771379 5ht2b_human Human No 5.4 EC50 = 4466.8 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
239 5 1 2 2.6 C=CCOc1ccc(F)c(F)c1C1CC1CN
CHEMBL4762225 5ht2b_human Human No 6.4 EC50 = 448 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12
CHEMBL4803142 5ht2b_human Human No 6.4 EC50 = 448 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12
CHEMBL201062 5ht2b_human Human No 7.4 EC50 = 45 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 3 2.5 C[C@H](N)Cn1ccc2ccc3cccnc3c21
CHEMBL4803306 5ht2b_human Human No 7.3 EC50 = 45.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL4538660 5ht2b_human Human No 6.4 EC50 = 450 nM Funct
Agonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
307 2 1 3 2.8 FC(F)(F)c1cccc(Cc2cc3c(nn2)CCNCC3)c1
CHEMBL3416054 5ht2b_human Human No 5.3 EC50 = 4521 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 1 2 2.8 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF
CHEMBL3546906 5ht2b_human Human No 5.3 EC50 = 4521 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 1 2 2.8 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF
CHEMBL4786831 5ht2b_human Human No 6.3 EC50 = 453 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803642 5ht2b_human Human No 6.3 EC50 = 453 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL3769828 5ht2b_human Human No 6.3 EC50 = 453 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1cc(F)c(F)cc1OCCF
CHEMBL3771383 5ht2b_human Human No 6.3 EC50 = 453 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1cc(F)c(F)cc1OCCF
CHEMBL4786831 5ht2b_human Human No 6.3 EC50 = 457.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803642 5ht2b_human Human No 6.3 EC50 = 457.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.3 CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL3770963 5ht2b_human Human No 6.3 EC50 = 457.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771381 5ht2b_human Human No 6.3 EC50 = 457.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3769828 5ht2b_human Human No 6.3 EC50 = 457.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1cc(F)c(F)cc1OCCF
CHEMBL3771383 5ht2b_human Human No 6.3 EC50 = 457.1 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 5 1 2 2.4 NCC1CC1c1cc(F)c(F)cc1OCCF
CHEMBL1187390 5ht2b_human Human No 6.3 EC50 = 459 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F
CHEMBL501526 5ht2b_human Human No 6.3 EC50 = 459 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
199 2 1 1 2.5 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F
CHEMBL4803306 5ht2b_human Human No 7.3 EC50 = 46 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
249 5 1 3 2.8 C1[C@@H]([C@H]1C2=C(C=CC3=C2C=CO3)OCCF)CN
CHEMBL590483 5ht2b_human Human No 7.3 EC50 = 46 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
251 0 2 3 1.2 O=C1NC2CCNCCN2c2cccc(Cl)c21
CHEMBL3416049 5ht2b_human Human No 5.3 EC50 = 4602 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
235 4 1 2 2.4 C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546975 5ht2b_human Human No 5.3 EC50 = 4602 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
235 4 1 2 2.4 C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3770963 5ht2b_human Human No 6.3 EC50 = 462 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL3771381 5ht2b_human Human No 6.3 EC50 = 462 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
213 3 1 2 2.0 COc1ccc(F)c(F)c1C1CC1CN
CHEMBL383042 5ht2b_human Human No 6.3 EC50 = 462 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
345 6 1 4 4.4 COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21
CHEMBL3769987 5ht2b_human Human No 6.3 EC50 = 467.7 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL3771387 5ht2b_human Human No 6.3 EC50 = 467.7 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
229 3 1 2 2.6 COc1ccc(Cl)c(F)c1C1CC1CN
CHEMBL576651 5ht2b_human Human No 6.3 EC50 = 473 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
323 2 1 4 2.0 O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2
CHEMBL360328 5ht2b_human Human Yes 6.3 EC50 = 478 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL492348 5ht2b_human Human No 6.3 EC50 = 478 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
336 3 2 3 2.8 O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2
CHEMBL492950 5ht2b_human Human No 6.3 EC50 = 478 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
316 3 1 3 2.2 CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2
CHEMBL4217787 5ht2b_human Human No 6.3 EC50 = 478 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
259 1 1 3 2.4 CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL4081247 5ht2b_human Human No 7.3 EC50 = 48 nM Funct
Agonist activity at recombinant human 5-HT2B receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in HEK293E cells assessed as induction of intracellular Ca2+ levels after 90 secs by Fluo-4-dye based FLIPR assay
316 3 1 6 3.2 CCn1nc(-c2cccc3cccnc23)cc1-c1ccc(N)nn1
CHEMBL210484 5ht2b_human Human No 7.3 EC50 = 48 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
272 1 1 4 1.7 C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1
CHEMBL4213971 5ht2b_human Human No 6.3 EC50 = 489 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
267 0 1 3 1.6 Brc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL80246 5ht2b_human Human No 7.3 EC50 = 49 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
262 2 1 2 2.6 C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21
CHEMBL3416059 5ht2b_human Human No 5.3 EC50 = 4911 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF
CHEMBL3546910 5ht2b_human Human No 5.3 EC50 = 4911 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF
CHEMBL1187377 5ht2b_human Human No 6.3 EC50 = 492 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
163 2 2 2 1.5 NC[C@H]1C[C@@H]1c1ccccc1O
CHEMBL501117 5ht2b_human Human No 6.3 EC50 = 492 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
163 2 2 2 1.5 NC[C@H]1C[C@@H]1c1ccccc1O
CHEMBL221113 5ht2b_human Human No 5.3 EC50 = 4926 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
284 1 1 2 2.4 CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21
CHEMBL219734 5ht2b_human Human No 6.3 EC50 = 498 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
272 1 1 3 1.7 O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12
CHEMBL2391541 5ht2b_human Human Yes 8.3 EC50 = 5.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12
CHEMBL2391541 5ht2b_human Human Yes 8.3 EC50 = 5.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
270 8 1 2 3.4 C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12
CHEMBL1187585 5ht2b_human Human No 8.3 EC50 = 5.5 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
163 2 2 2 1.5 NC[C@H]1C[C@@H]1c1cccc(O)c1
CHEMBL510383 5ht2b_human Human No 8.3 EC50 = 5.5 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
163 2 2 2 1.5 NC[C@H]1C[C@@H]1c1cccc(O)c1
CHEMBL397321 5ht2b_rat Rat No 8.2 EC50 = 5.8 nM Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
307 7 1 5 1.6 COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2
CHEMBL39 5ht2b_human Human Yes 8.2 EC50 = 5.8 nM Funct
Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL373245 5ht2b_rat Rat Yes 8.2 EC50 = 5.9 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
225 2 2 4 1.7 C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21
CHEMBL3937394 5ht2b_human Human No 7.3 EC50 = 50.1 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
202 0 1 2 1.7 Cc1cccc2c1N1CCNCC1CC2
CHEMBL4750216 5ht2b_human Human No 7.3 EC50 = 50.1 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
223 0 1 3 1.5 Clc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL178366 5ht2b_human Human No 7.3 EC50 = 50.1 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.2 CC1CNCCc2cc(Cl)c(Cl)cc21
CHEMBL4644315 5ht2b_human Human No 6.3 EC50 = 500 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
202 0 1 2 1.9 c1cc2c3c(c1)CNCCN3CCCC2
CHEMBL4638592 5ht2b_human Human No 4.3 EC50 = 50000 nM Funct
Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay
319 4 0 4 4.2 CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1
CHEMBL223896 5ht2b_human Human No 6.3 EC50 = 501 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
222 0 1 2 1.4 O=C1c2c(Cl)cccc2C2CNCCN12
CHEMBL4796102 5ht2b_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay
305 4 1 4 3.5 N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1
CHEMBL3919861 5ht2b_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
216 0 1 2 2.2 c1ccc2c(c1)CC[C@@H]1CCNCCCN21
CHEMBL181672 5ht2b_human Human Yes 6.3 EC50 = 501.2 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
195 0 1 1 2.6 CC1CNCCc2cc(Cl)ccc21
CHEMBL254009 5ht2b_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.0 C[C@H]1CNCCc2ccc(C(F)(F)F)cc21
CHEMBL3769421 5ht2b_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3771385 5ht2b_human Human No 6.3 EC50 = 501.2 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL361742 5ht2b_human Human Yes 5.3 EC50 = 5011.9 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
191 1 1 2 1.9 COc1ccc2c(c1)C(C)CNCC2
CHEMBL3416041 5ht2b_human Human No 5.3 EC50 = 5012 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL3546951 5ht2b_human Human No 5.3 EC50 = 5012 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.2 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1
CHEMBL1643854 5ht2b_human Human No 6.3 EC50 = 503 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
365 4 1 7 1.7 COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1
CHEMBL572252 5ht2b_human Human No 6.3 EC50 = 506 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay
348 5 1 6 1.9 C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O
CHEMBL3769421 5ht2b_human Human No 6.3 EC50 = 506 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL3771385 5ht2b_human Human No 6.3 EC50 = 506 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 2.9 NCC1CC1c1cc(Cl)c(F)cc1OCCF
CHEMBL1186700 5ht2b_human Human No 6.3 EC50 = 510 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
197 2 1 1 2.9 NC[C@H]1C[C@@H]1c1ccc2ccccc2c1
CHEMBL474885 5ht2b_human Human No 6.3 EC50 = 510 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
197 2 1 1 2.9 NC[C@H]1C[C@@H]1c1ccc2ccccc2c1
CHEMBL4752604 5ht2b_human Human No 6.3 EC50 = 512.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4802785 5ht2b_human Human No 6.3 EC50 = 512.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL360328 5ht2b_human Human Yes 6.3 EC50 = 512.9 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL2337496 5ht2b_human Human No 6.3 EC50 = 523 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
236 0 2 2 1.4 Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL2365472 5ht2b_human Human No 6.3 EC50 = 523 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
236 0 2 2 1.4 Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O
CHEMBL4752604 5ht2b_human Human No 6.3 EC50 = 524 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL4802785 5ht2b_human Human No 6.3 EC50 = 524 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.3 NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12
CHEMBL1186115 5ht2b_human Human No 7.3 EC50 = 53 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL450599 5ht2b_human Human No 7.3 EC50 = 53 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1ccccc1[C@H]1C[C@@H]1CN
CHEMBL181672 5ht2b_human Human Yes 6.3 EC50 = 530 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
195 0 1 1 2.6 CC1CNCCc2cc(Cl)ccc21
CHEMBL3416042 5ht2b_human Human No 5.3 EC50 = 5300 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 6 1 3 2.4 COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546871 5ht2b_human Human No 5.3 EC50 = 5300 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 6 1 3 2.4 COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL4790652 5ht2b_human Human No 7.3 EC50 = 54 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4803766 5ht2b_human Human No 7.3 EC50 = 54 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4803134 5ht2b_human Human No 6.3 EC50 = 549.5 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
277 6 1 3 3.4 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCCF
CHEMBL4803134 5ht2b_human Human No 6.3 EC50 = 550 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
277 6 1 3 3.4 CCC1=CC2=C(O1)C=CC(=C2[C@H]3C[C@@H]3CN)OCCF
CHEMBL4086286 5ht2b_human Human No 7.3 EC50 = 56 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF
CHEMBL4117192 5ht2b_human Human No 7.3 EC50 = 56 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF
CHEMBL2397878 5ht2b_human Human No 7.3 EC50 = 56 nM Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
232 1 1 3 0.7 COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2
CHEMBL4086286 5ht2b_human Human No 7.3 EC50 = 56.2 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF
CHEMBL4117192 5ht2b_human Human No 7.3 EC50 = 56.2 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
347 9 1 3 4.1 COc1ccc(F)cc1C1CC1CNCc1ccccc1OCCF
CHEMBL4537637 5ht2b_human Human No 6.3 EC50 = 562.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
179 3 1 1 2.1 CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL4595810 5ht2b_human Human No 6.3 EC50 = 562.3 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
179 3 1 1 2.1 CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL4537637 5ht2b_human Human No 6.3 EC50 = 565 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
179 3 1 1 2.1 CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL4595810 5ht2b_human Human No 6.3 EC50 = 565 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
179 3 1 1 2.1 CNC[C@H]1C[C@]1(F)c1ccccc1
CHEMBL594717 5ht2b_human Human No 6.3 EC50 = 566 nM Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
355 4 1 4 3.5 Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21
CHEMBL3416038 5ht2b_human Human No 5.3 EC50 = 5660 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 4 1 2 3.2 CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546893 5ht2b_human Human No 5.3 EC50 = 5660 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
239 4 1 2 3.2 CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL220900 5ht2b_human Human No 7.2 EC50 = 57 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
256 0 1 2 2.1 O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12
CHEMBL4117313 5ht2b_human Human No 6.2 EC50 = 570 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COC1=C(C=C(C=C1)F)[C@@H]2C[C@H]2CNCC3=CC=CC=C3OC
CHEMBL4117313 5ht2b_human Human No 6.2 EC50 = 575.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
315 7 1 3 3.7 COC1=C(C=C(C=C1)F)[C@@H]2C[C@H]2CNCC3=CC=CC=C3OC
CHEMBL65547 5ht2b_human Human Yes 7.2 EC50 = 58 nM Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay
204 3 2 2 2.0 CN(CCc1c[nH]c2c1c(O)ccc2)C
CHEMBL4790652 5ht2b_human Human No 7.2 EC50 = 58.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4803766 5ht2b_human Human No 7.2 EC50 = 58.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4799299 5ht2b_human Human No 6.2 EC50 = 585 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4804137 5ht2b_human Human No 6.2 EC50 = 585 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4799299 5ht2b_human Human No 6.2 EC50 = 588.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4804137 5ht2b_human Human No 6.2 EC50 = 588.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
261 5 1 3 3.4 C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL232995 5ht2b_rat Rat No 7.2 EC50 = 59 nM Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
383 7 1 6 2.6 C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2
CHEMBL1187194 5ht2b_human Human Yes 7.2 EC50 = 59 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1cccc(Cl)c1
CHEMBL493128 5ht2b_human Human Yes 7.2 EC50 = 59 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
181 2 1 1 2.4 NC[C@H]1C[C@@H]1c1cccc(Cl)c1
CHEMBL209254 5ht2b_human Human No 7.2 EC50 = 59 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
222 1 1 2 2.1 Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1
CHEMBL4642763 5ht2b_human Human No 5.2 EC50 = 5930 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
208 0 1 2 1.8 Clc1ccc2c3c1CCN3CCNC2
CHEMBL197653 5ht2b_rat Rat Yes 8.2 EC50 = 6.1 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
209 2 2 4 1.2 C[C@H](N)Cn1ncc2ccc(O)c(F)c21
CHEMBL391196 5ht2b_rat Rat No 8.2 EC50 = 6.2 nM Funct
Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT
313 2 2 4 1.7 C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2
CHEMBL76307 5ht2b_human Human Yes 8.2 EC50 = 6.5 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
210 2 1 2 2.1 C[C@H](N)CN1CCc2ccc(Cl)cc21
CHEMBL4748110 5ht2b_human Human No 7.2 EC50 = 60 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL4802669 5ht2b_human Human No 7.2 EC50 = 60 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL1770383 5ht2b_human Human No 7.2 EC50 = 60 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
273 2 1 3 2.4 Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL4748110 5ht2b_human Human No 7.2 EC50 = 60.3 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL4802669 5ht2b_human Human No 7.2 EC50 = 60.3 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
245 4 1 3 3.1 CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1
CHEMBL4636014 5ht2b_human Human No 5.2 EC50 = 6000 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
202 0 1 2 2.1 C[C@@H]1c2cccc3c2N(CCNC3)[C@@H]1C
CHEMBL1643674 5ht2b_human Human No 6.2 EC50 = 602 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
231 2 2 5 0.8 CCNc1c2c(nc3ccnn13)CCNCC2
CHEMBL3769454 5ht2b_human Human No 6.2 EC50 = 602.6 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2b_human Human No 6.2 EC50 = 602.6 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3769454 5ht2b_human Human No 6.2 EC50 = 605 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3771393 5ht2b_human Human No 6.2 EC50 = 605 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
245 3 1 2 3.1 COc1ccc(Cl)c(Cl)c1C1CC1CN
CHEMBL3416052 5ht2b_human Human No 5.2 EC50 = 6094 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.4 C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546904 5ht2b_human Human No 5.2 EC50 = 6094 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
251 5 1 2 3.4 C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL590580 5ht2b_human Human No 7.2 EC50 = 61 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay
231 0 2 3 0.9 Cc1cccc2c1C(=O)NC1CCNCCN21
CHEMBL4209572 5ht2b_human Human No 7.2 EC50 = 61.2 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
189 0 1 3 0.8 c1cnc2c(c1)CC[C@@H]1CNCCN21
CHEMBL1770377 5ht2b_human Human No 6.2 EC50 = 610 nM Funct
Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay
257 2 1 3 1.9 Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1
CHEMBL3416058 5ht2b_human Human No 5.2 EC50 = 6166 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF
CHEMBL3546873 5ht2b_human Human No 5.2 EC50 = 6166 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
257 6 1 2 3.1 NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF
CHEMBL201897 5ht2b_human Human No 7.2 EC50 = 62 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
225 2 1 3 2.5 C[C@H](N)Cn1ccc2ccc3ccncc3c21
CHEMBL210802 5ht2b_human Human Yes 7.2 EC50 = 62 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
258 1 1 4 1.3 FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1
CHEMBL3895184 5ht2b_human Human No 7.2 EC50 = 63.1 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
266 1 1 3 2.5 COc1cc2c(cc1Cl)CC[C@@H]1CNCCCN21
CHEMBL3946277 5ht2b_human Human No 7.2 EC50 = 63.1 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
188 0 1 2 1.4 c1ccc2c(c1)CC[C@@H]1CNCCN21
CHEMBL4209572 5ht2b_human Human No 7.2 EC50 = 63.1 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
189 0 1 3 0.8 c1cnc2c(c1)CC[C@@H]1CNCCN21
CHEMBL181787 5ht2b_human Human No 7.2 EC50 = 63.1 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
225 1 1 2 2.6 COc1cc2c(cc1Cl)C(C)CNCC2
CHEMBL3928762 5ht2b_human Human No 6.2 EC50 = 631.0 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
250 0 1 2 2.8 Clc1ccc2c(c1)CCC1CCNCCCN21
CHEMBL3933563 5ht2b_human Human No 6.2 EC50 = 631.0 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
220 0 1 2 1.9 Fc1ccc2c(c1)CC[C@@H]1CNCCCN21
CHEMBL3950846 5ht2b_human Human No 6.2 EC50 = 631.0 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
230 2 1 2 2.4 CCCc1ccc2c(c1)CCC1CNCCN21
CHEMBL3956394 5ht2b_human Human No 6.2 EC50 = 631.0 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
296 2 1 2 3.1 Fc1ccc2c(c1Cc1ccccc1)CCC1CNCCN21
CHEMBL3966227 5ht2b_human Human No 6.2 EC50 = 631.0 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
232 1 1 3 1.8 COc1ccc2c(c1)N1CCCNC[C@H]1CC2
CHEMBL253810 5ht2b_human Human No 6.2 EC50 = 631.0 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
209 1 1 1 3.0 CC[C@@H]1CNCCc2ccc(Cl)cc21
CHEMBL3956136 5ht2b_human Human No 5.2 EC50 = 6309.6 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
280 2 1 3 3.2 c1ccc(Oc2cccc3c2CCC2CNCCN32)cc1
CHEMBL3416055 5ht2b_human Human No 6.2 EC50 = 632 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 1 2 2.8 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF
CHEMBL3546907 5ht2b_human Human No 6.2 EC50 = 632 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
243 5 1 2 2.8 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF
CHEMBL179378 5ht2b_human Human Yes 7.2 EC50 = 64 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
317 1 1 2 2.5 COc1cc2c(cc1I)C(C)CNCC2
CHEMBL4090984 5ht2b_human Human No 6.2 EC50 = 641 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 5 1 2 2.7 COc1ccc(F)cc1C1CC1CNC1CC1
CHEMBL4117952 5ht2b_human Human No 6.2 EC50 = 641 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 5 1 2 2.7 COc1ccc(F)cc1C1CC1CNC1CC1
CHEMBL4636196 5ht2b_human Human No 5.2 EC50 = 6420 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
214 0 1 2 2.0 c1cc2c3c(c1)C1(CCC1)CN3CCNC2
CHEMBL4090984 5ht2b_human Human No 6.2 EC50 = 645.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 5 1 2 2.7 COc1ccc(F)cc1C1CC1CNC1CC1
CHEMBL4117952 5ht2b_human Human No 6.2 EC50 = 645.7 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
235 5 1 2 2.7 COc1ccc(F)cc1C1CC1CNC1CC1
CHEMBL1186019 5ht2b_human Human Yes 7.2 EC50 = 65 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL445747 5ht2b_human Human Yes 7.2 EC50 = 65 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
161 2 1 1 2.1 Cc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL209714 5ht2b_human Human No 7.2 EC50 = 65 nM Funct
Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells
256 1 1 2 2.5 FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1
CHEMBL494947 5ht2b_human Human Yes 7.2 EC50 = 65.3 nM Bind
Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control
304 4 1 5 2.1 Clc1cccc(COc2cncc(N3CCNCC3)n2)c1
CHEMBL3416050 5ht2b_human Human No 5.2 EC50 = 6877 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.3 C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL3546872 5ht2b_human Human No 5.2 EC50 = 6877 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.3 C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN
CHEMBL1187580 5ht2b_human Human Yes 7.2 EC50 = 69 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
165 2 1 1 1.9 NC[C@H]1C[C@@H]1c1ccccc1F
CHEMBL510308 5ht2b_human Human Yes 7.2 EC50 = 69 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
165 2 1 1 1.9 NC[C@H]1C[C@@H]1c1ccccc1F
CHEMBL493152 5ht2b_human Human No 7.2 EC50 = 69 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
302 3 2 3 2.2 O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2
CHEMBL1186687 5ht2b_human Human No 8.2 EC50 = 7 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
195 2 1 1 2.7 Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN
CHEMBL474634 5ht2b_human Human No 8.2 EC50 = 7 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
195 2 1 1 2.7 Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN
CHEMBL80366 5ht2b_human Human No 8.1 EC50 = 7.3 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
228 2 1 2 2.2 C[C@H](N)CN1CCc2cc(F)c(Cl)cc21
CHEMBL3934644 5ht2b_human Human No 8.1 EC50 = 7.9 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
266 1 1 3 2.5 COc1ccc2c(c1Cl)N1CCCNC[C@H]1CC2
CHEMBL2337105 5ht2b_human Human No 6.2 EC50 = 706 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
244 1 2 2 1.9 Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21
CHEMBL2365394 5ht2b_human Human No 6.2 EC50 = 706 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
244 1 2 2 1.9 Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21
CHEMBL1643855 5ht2b_human Human No 6.2 EC50 = 706 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
336 3 1 7 1.1 c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1
CHEMBL3771152 5ht2b_human Human No 6.2 EC50 = 714 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL3771392 5ht2b_human Human No 6.2 EC50 = 714 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL80862 5ht2b_human Human No 7.1 EC50 = 72 nM Funct
Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader
236 4 1 3 2.5 CCSc1ccc2c(c1)N(C[C@H](C)N)CC2
CHEMBL4739937 5ht2b_human Human No 6.1 EC50 = 724.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4802378 5ht2b_human Human No 6.1 EC50 = 724.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4762722 5ht2b_human Human No 6.1 EC50 = 724.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803207 5ht2b_human Human No 6.1 EC50 = 724.4 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL3771152 5ht2b_human Human No 6.1 EC50 = 724.4 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL3771392 5ht2b_human Human No 6.1 EC50 = 724.4 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
271 5 1 2 3.6 C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN
CHEMBL4739937 5ht2b_human Human No 6.1 EC50 = 725 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4802378 5ht2b_human Human No 6.1 EC50 = 725 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
217 3 1 3 2.5 COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL1643859 5ht2b_human Human No 7.1 EC50 = 73 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
390 3 2 7 1.2 O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1
CHEMBL4762722 5ht2b_human Human No 6.1 EC50 = 733 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL4803207 5ht2b_human Human No 6.1 EC50 = 733 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
257 5 1 3 3.5 C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN
CHEMBL3416060 5ht2b_human Human No 6.1 EC50 = 735 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
223 5 1 2 2.7 CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN
CHEMBL3546911 5ht2b_human Human No 6.1 EC50 = 735 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
223 5 1 2 2.7 CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN
CHEMBL194378 5ht2b_human Human Yes 7.1 EC50 = 74 nM Funct
Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay
284 5 3 3 1.7 CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12
CHEMBL595553 5ht2b_human Human No 6.1 EC50 = 748 nM Funct
Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay
329 3 1 4 3.2 Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21
CHEMBL1187195 5ht2b_human Human No 7.1 EC50 = 75 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL493129 5ht2b_human Human No 7.1 EC50 = 75 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
177 3 1 2 1.8 COc1cccc([C@H]2C[C@@H]2CN)c1
CHEMBL522349 5ht2b_human Human No 7.1 EC50 = 75 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
320 3 2 3 2.3 O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2
CHEMBL30713 5ht2b_human Human Yes 7.1 EC50 = 75.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12
CHEMBL30713 5ht2b_human Human Yes 7.1 EC50 = 75.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay
174 2 2 1 2.1 CC(N)Cc1c[nH]c2ccccc12
CHEMBL4761526 5ht2b_human Human No 7.1 EC50 = 75.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4803123 5ht2b_human Human No 7.1 EC50 = 75.9 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4213379 5ht2b_human Human No 6.1 EC50 = 758 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
279 2 1 3 2.4 c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1
CHEMBL4761526 5ht2b_human Human No 7.1 EC50 = 77 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL4803123 5ht2b_human Human No 7.1 EC50 = 77 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
219 3 1 3 1.7 COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2
CHEMBL1187088 5ht2b_human Human No 7.1 EC50 = 77 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 2.8 NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1
CHEMBL490064 5ht2b_human Human No 7.1 EC50 = 77 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 2.8 NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1
CHEMBL4789310 5ht2b_human Human No 6.1 EC50 = 776.3 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4803705 5ht2b_human Human No 6.1 EC50 = 776.3 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4217846 5ht2b_human Human No 6.1 EC50 = 779 nM Funct
Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method
189 0 1 3 0.8 c1cc2c(cn1)N1CCNC[C@H]1CC2
CHEMBL178366 5ht2b_human Human No 7.1 EC50 = 78 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 1 3.2 CC1CNCCc2cc(Cl)c(Cl)cc21
CHEMBL361742 5ht2b_human Human Yes 6.1 EC50 = 780 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
191 1 1 2 1.9 COc1ccc2c(c1)C(C)CNCC2
CHEMBL4789310 5ht2b_human Human No 6.1 EC50 = 781 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL4803705 5ht2b_human Human No 6.1 EC50 = 781 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
233 4 1 3 2.1 CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2
CHEMBL3979806 5ht2b_human Human No 7.1 EC50 = 79.4 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
248 2 1 3 2.5 CCSc1cccc2c1CCC1CNCCN21
CHEMBL360328 5ht2b_human Human Yes 7.1 EC50 = 79.4 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL3907399 5ht2b_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
258 2 1 3 2.3 c1cc(OC2CCC2)c2c(c1)N1CCNCC1CC2
CHEMBL3975593 5ht2b_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
218 1 1 3 1.4 COc1ccc2c(c1)CCC1CNCCN21
CHEMBL4213379 5ht2b_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
279 2 1 3 2.4 c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1
CHEMBL4217846 5ht2b_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
189 0 1 3 0.8 c1cc2c(cn1)N1CCNC[C@H]1CC2
CHEMBL4785566 5ht2b_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assayAgonist activity at 5-HT2BR (unknown origin) transfected in human HEK293 cells by IP3 accumulation assay
233 2 1 4 1.0 COCc1ccnc2c1CC[C@@H]1CNCCN21
CHEMBL360328 5ht2b_human Human Yes 6.1 EC50 = 794.3 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL178124 5ht2b_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.0 CC1CNCCc2ccc(C(F)(F)F)cc21
CHEMBL179337 5ht2b_human Human Yes 6.1 EC50 = 794.3 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.2 CC1CNCCc2c(Cl)cc(Cl)cc21
CHEMBL254215 5ht2b_human Human No 6.1 EC50 = 794.3 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation
229 0 1 1 3.0 C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21
CHEMBL3961589 5ht2b_human Human No 5.1 EC50 = 7943.3 nM Funct
Agonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation countingAgonist activity at 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by scintillation counting
310 2 1 2 3.5 Fc1ccc2c(c1Cc1ccccc1)CC[C@@H]1CNCCCN21
CHEMBL223468 5ht2b_human Human No 8.1 EC50 = 8 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.4 CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21
CHEMBL1186736 5ht2b_human Human No 8.1 EC50 = 8.4 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
175 2 1 1 2.4 Cc1cccc([C@H]2C[C@@H]2CN)c1C
CHEMBL475642 5ht2b_human Human No 8.1 EC50 = 8.4 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
175 2 1 1 2.4 Cc1cccc([C@H]2C[C@@H]2CN)c1C
CHEMBL199385 5ht2b_rat Rat Yes 8.1 EC50 = 8.6 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
177 2 2 4 0.7 NCCn1ncc2ccc(O)cc21
CHEMBL200104 5ht2b_rat Rat Yes 8.1 EC50 = 8.9 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
205 2 2 4 1.4 Cc1c(O)ccc2cnn(C[C@H](C)N)c12
CHEMBL360328 5ht2b_human Human Yes 7.1 EC50 = 80 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
195 0 1 1 2.6 Clc1ccc2c(c1)[C@@H](C)CNCC2
CHEMBL4632473 5ht2b_human Human No 6.1 EC50 = 800 nM Funct
Agonist activity at 5HT2B receptor (unknown origin)Agonist activity at 5HT2B receptor (unknown origin)
256 0 1 2 3.0 CC1CN2CCNCc3cc(Cl)c(Cl)c1c32
CHEMBL4463588 5ht2b_human Human No 6.1 EC50 = 800 nM Funct
Agonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR assay
273 2 1 3 2.4 Clc1ccccc1Cc1cc2c(nn1)CCNCC2
CHEMBL492349 5ht2b_human Human No 6.1 EC50 = 802 nM Funct
Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system
350 4 2 3 2.5 O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2
CHEMBL4073529 5ht2b_human Human No 6.1 EC50 = 807 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
341 6 1 3 4.9 COc1ccc(F)cc1C1CC1CNCc1cccc2ccsc12
CHEMBL4116914 5ht2b_human Human No 6.1 EC50 = 807 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
341 6 1 3 4.9 COc1ccc(F)cc1C1CC1CNCc1cccc2ccsc12
CHEMBL577691 5ht2b_human Human No 7.1 EC50 = 81 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
289 2 1 4 1.6 O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2
CHEMBL4073529 5ht2b_human Human No 6.1 EC50 = 812.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
341 6 1 3 4.9 COc1ccc(F)cc1C1CC1CNCc1cccc2ccsc12
CHEMBL4116914 5ht2b_human Human No 6.1 EC50 = 812.8 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
341 6 1 3 4.9 COc1ccc(F)cc1C1CC1CNCc1cccc2ccsc12
CHEMBL223628 5ht2b_human Human No 6.1 EC50 = 825 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
246 2 1 3 1.6 CC(C)Oc1cccc2c1C(=O)N1CCNCC21
CHEMBL2397913 5ht2b_human Human No 6.1 EC50 = 827 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
246 1 1 3 1.0 COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O
CHEMBL1186164 5ht2b_human Human No 7.1 EC50 = 83 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl
CHEMBL452458 5ht2b_human Human No 7.1 EC50 = 83 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
215 2 1 1 3.1 NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl
CHEMBL3416057 5ht2b_human Human No 6.1 EC50 = 839 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 3.0 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F
CHEMBL3546909 5ht2b_human Human No 6.1 EC50 = 839 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
261 5 1 2 3.0 NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F
CHEMBL4756903 5ht2b_human Human No 7.1 EC50 = 84 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803034 5ht2b_human Human No 7.1 EC50 = 84 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL568692 5ht2b_human Human No 7.1 EC50 = 84 nM Funct
Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay
295 3 1 4 1.9 O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2
CHEMBL179337 5ht2b_human Human Yes 6.1 EC50 = 840 nM Funct
Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release
229 0 1 1 3.2 CC1CNCCc2c(Cl)cc(Cl)cc21
CHEMBL1643673 5ht2b_human Human No 6.1 EC50 = 842 nM Funct
Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay
245 2 1 5 0.9 CCN(C)c1c2c(nc3ccnn13)CCNCC2
CHEMBL437314 5ht2b_rat Rat Yes 7.1 EC50 = 85 nM Funct
Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
191 2 2 4 1.1 C[C@@H](N)Cn1ncc2ccc(O)cc21
CHEMBL1187354 5ht2b_human Human Yes 7.1 EC50 = 85 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NCC1CC1c1ccccc1
CHEMBL500093 5ht2b_human Human Yes 7.1 EC50 = 85 nM Funct
Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
147 2 1 1 1.7 NCC1CC1c1ccccc1
CHEMBL4756903 5ht2b_human Human No 7.1 EC50 = 85.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL4803034 5ht2b_human Human No 7.1 EC50 = 85.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay
231 4 1 3 2.9 CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN
CHEMBL3416033 5ht2b_human Human No 7.1 EC50 = 86 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 4 1 2 2.8 CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL3546889 5ht2b_human Human No 7.1 EC50 = 86 nM Funct
Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay
225 4 1 2 2.8 CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN
CHEMBL220207 5ht2b_human Human No 7.1 EC50 = 87 nM Funct
Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay
234 1 1 3 1.5 CSc1cccc2c1C(=O)N1CCNCC21
CHEMBL4064935 5ht2b_human Human No 7.1 EC50 = 87 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
336 6 1 3 4.3 COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12
CHEMBL4116446 5ht2b_human Human No 7.1 EC50 = 87 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
336 6 1 3 4.3 COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12
CHEMBL4064935 5ht2b_human Human No 7.1 EC50 = 87.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
336 6 1 3 4.3 COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12
CHEMBL4116446 5ht2b_human Human No 7.1 EC50 = 87.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
336 6 1 3 4.3 COc1ccc(F)cc1C1CC1CNCc1cccc2cccnc12
CHEMBL4116620 5ht2b_human Human No 7.1 EC50 = 89 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
209 4 1 2 2.2 CNC[C@H]1C[C@@H]1C2=C(C=CC(=C2)F)OC
CHEMBL4116620 5ht2b_human Human No 7.1 EC50 = 89.1 nM Funct
Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay
209 4 1 2 2.2 CNC[C@H]1C[C@@H]1C2=C(C=CC(=C2)F)OC
CHEMBL2397877 5ht2b_human Human No 8.1 EC50 = 9 nM Funct
Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay
236 0 1 2 1.3 O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12
CHEMBL2337490 5ht2b_human Human No 8.0 EC50 = 9.9 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.5 O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21
CHEMBL2365083 5ht2b_human Human No 8.0 EC50 = 9.9 nM Funct
Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay
256 0 2 2 1.5 O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21
CHEMBL4472830 5ht2b_human Human No 6.0 EC50 = 903 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
165 2 1 1 1.8 NC[C@@H]1C[C@@]1(F)c1ccccc1
CHEMBL4598081 5ht2b_human Human No 6.0 EC50 = 903 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
165 2 1 1 1.8 NC[C@@H]1C[C@@]1(F)c1ccccc1
CHEMBL202324 5ht2b_human Human No 7.0 EC50 = 91 nM Bind
Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells
265 5 1 3 3.4 C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21
CHEMBL4472830 5ht2b_human Human No 6.0 EC50 = 912.0 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
165 2 1 1 1.8 NC[C@@H]1C[C@@]1(F)c1ccccc1
CHEMBL4598081 5ht2b_human Human No 6.0 EC50 = 912.0 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay
165 2 1 1 1.8 NC[C@@H]1C[C@@]1(F)c1ccccc1
CHEMBL3769704 5ht2b_human Human No 6.0 EC50 = 927 nM Funct
Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay
255 5 1 2 3.1