GPCRdb

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	3036780	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3036780.0	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	46780481	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970.0	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL504548	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	DB06216	107587	None	16	Human	Functional	pAC50	=	8.9	8.9	-6	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3151	1462	None	65	Human	Functional	pAC50	=	5	5.0	-1905	24	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	3151.0	1462	None	65	Human	Functional	pAC50	=	5	5.0	-1905	24	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1462	None	65	Human	Functional	pAC50	=	5	5.0	-1905	24	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1462	None	65	Human	Functional	pAC50	=	5	5.0	-1905	24	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1462	None	65	Human	Functional	pAC50	=	5	5.0	-1905	24	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1462	None	65	Human	Functional	pAC50	=	5	5.0	-1905	24	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	216239	23803	None	71	Human	Functional	pAC50	=	5	5.0	-5	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23803	None	71	Human	Functional	pAC50	=	5	5.0	-5	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23803	None	71	Human	Functional	pAC50	=	5	5.0	-5	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	2176	49659	None	55	Human	Functional	pAC50	=	5	5.0	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1566249	49659	None	55	Human	Functional	pAC50	=	5	5.0	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	72106	78221	None	44	Human	Functional	pAC50	=	5	5.0	-3	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL2105059	78221	None	44	Human	Functional	pAC50	=	5	5.0	-3	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	45138674	16653	None	45	Human	Functional	pAC50	=	5	5.0	-5	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16653	None	45	Human	Functional	pAC50	=	5	5.0	-5	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	439280	120083	None	57	Human	Functional	pAC50	=	5	5.0	-25	9	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	6971044	120083	None	57	Human	Functional	pAC50	=	5	5.0	-25	9	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL350221	120083	None	57	Human	Functional	pAC50	=	5	5.0	-25	9	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	432824	78293	None	10	Human	Functional	pAC50	=	6	6.0	-1	4	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	CHEMBL2106996	78293	None	10	Human	Functional	pAC50	=	6	6.0	-1	4	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	7.0	7.0	-33	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	7.0	7.0	-33	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	7.0	7.0	-33	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	7.0	7.0	-33	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	7.0	7.0	-33	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	7.0	7.0	-33	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	123606	352	None	46	Human	Functional	pAC50	=	5.0	5.0	-199	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	123606.0	352	None	46	Human	Functional	pAC50	=	5.0	5.0	-199	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	352	None	46	Human	Functional	pAC50	=	5.0	5.0	-199	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	352	None	46	Human	Functional	pAC50	=	5.0	5.0	-199	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	352	None	46	Human	Functional	pAC50	=	5.0	5.0	-199	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	352	None	46	Human	Functional	pAC50	=	5.0	5.0	-199	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	5994	4643	None	51	Human	Functional	pAC50	=	5.0	5.0	-3	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4643	None	51	Human	Functional	pAC50	=	5.0	5.0	-3	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	2335	11852	None	18	Human	Functional	pAC50	=	5.0	5.0	-81	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11852	None	18	Human	Functional	pAC50	=	5.0	5.0	-81	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11852	None	18	Human	Functional	pAC50	=	5.0	5.0	-81	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11852	None	18	Human	Functional	pAC50	=	5.0	5.0	-81	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	3149	12618	None	11	Human	Functional	pAC50	=	5.0	5.0	-30	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12618	None	11	Human	Functional	pAC50	=	5.0	5.0	-30	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	56959	31564	None	60	Human	Functional	pAC50	=	5.0	5.0	-7	9	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31564	None	60	Human	Functional	pAC50	=	5.0	5.0	-7	9	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31564	None	60	Human	Functional	pAC50	=	5.0	5.0	-7	9	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	4034	55838	None	37	Human	Functional	pAC50	=	5.0	5.0	-8	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	4034.0	55838	None	37	Human	Functional	pAC50	=	5.0	5.0	-8	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55838	None	37	Human	Functional	pAC50	=	5.0	5.0	-8	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	DB00737	55838	None	37	Human	Functional	pAC50	=	5.0	5.0	-8	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	71398	106495	None	32	Human	Functional	pAC50	=	5.0	5.0	-1548	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106495	None	32	Human	Functional	pAC50	=	5.0	5.0	-1548	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	180	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-398	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-398	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-398	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160.0	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-398	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-398	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	401	None	38	Human	Functional	pAC50	=	6.0	6.0	-398	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1890	2759	None	31	Human	Functional	pAC50	=	6.0	6.0	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2759	None	31	Human	Functional	pAC50	=	6.0	6.0	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2759	None	31	Human	Functional	pAC50	=	6.0	6.0	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2759	None	31	Human	Functional	pAC50	=	6.0	6.0	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2759	None	31	Human	Functional	pAC50	=	6.0	6.0	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	3316	31768	None	42	Human	Functional	pAC50	=	6.0	6.0	17	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31768	None	42	Human	Functional	pAC50	=	6.0	6.0	17	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	4993	122423	None	61	Human	Functional	pAC50	=	5.0	5.0	-5	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122423	None	61	Human	Functional	pAC50	=	5.0	5.0	-5	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	441074	19421	None	48	Human	Functional	pAC50	=	5.9	5.9	1	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19421	None	48	Human	Functional	pAC50	=	5.9	5.9	1	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	3658	4107	None	38	Human	Functional	pAC50	=	5.9	5.9	-141	18	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4107	None	38	Human	Functional	pAC50	=	5.9	5.9	-141	18	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4107	None	38	Human	Functional	pAC50	=	5.9	5.9	-141	18	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709.0	4107	None	38	Human	Functional	pAC50	=	5.9	5.9	-141	18	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4107	None	38	Human	Functional	pAC50	=	5.9	5.9	-141	18	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4107	None	38	Human	Functional	pAC50	=	5.9	5.9	-141	18	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	191	403	None	60	Human	Functional	pAC50	=	6.9	6.9	-3	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	403	None	60	Human	Functional	pAC50	=	6.9	6.9	-3	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	403	None	60	Human	Functional	pAC50	=	6.9	6.9	-3	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170.0	403	None	60	Human	Functional	pAC50	=	6.9	6.9	-3	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	403	None	60	Human	Functional	pAC50	=	6.9	6.9	-3	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	403	None	60	Human	Functional	pAC50	=	6.9	6.9	-3	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	1613	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-3	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-3	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-3	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964.0	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-3	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-3	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2348	None	42	Human	Functional	pAC50	=	6.9	6.9	-3	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4640	78295	None	23	Human	Functional	pAC50	=	6.9	6.9	1	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78295	None	23	Human	Functional	pAC50	=	6.9	6.9	1	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	3158	56283	None	21	Human	Functional	pAC50	=	5.9	5.9	-323	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	3158.0	56283	None	21	Human	Functional	pAC50	=	5.9	5.9	-323	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56283	None	21	Human	Functional	pAC50	=	5.9	5.9	-323	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	DB01142	56283	None	21	Human	Functional	pAC50	=	5.9	5.9	-323	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	4011	82440	None	34	Human	Functional	pAC50	=	5.9	5.9	-75	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82440	None	34	Human	Functional	pAC50	=	5.9	5.9	-75	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2520	206466	None	47	Human	Functional	pAC50	=	5.9	5.9	-1	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	206466	None	47	Human	Functional	pAC50	=	5.9	5.9	-1	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	206466	None	47	Human	Functional	pAC50	=	5.9	5.9	-1	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	5906	14501	None	15	Human	Functional	pAC50	=	4.9	4.9	1	4	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	5906.0	14501	None	15	Human	Functional	pAC50	=	4.9	4.9	1	4	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14501	None	15	Human	Functional	pAC50	=	4.9	4.9	1	4	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	DB00610	14501	None	15	Human	Functional	pAC50	=	4.9	4.9	1	4	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	72093	35070	None	5	Human	Functional	pAC50	=	4.9	4.9	-2	28	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35070	None	5	Human	Functional	pAC50	=	4.9	4.9	-2	28	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35070	None	5	Human	Functional	pAC50	=	4.9	4.9	-2	28	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4746	207349	None	24	Human	Functional	pAC50	=	4.9	4.9	-10	19	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	207349	None	24	Human	Functional	pAC50	=	4.9	4.9	-10	19	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	207349	None	24	Human	Functional	pAC50	=	4.9	4.9	-10	19	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	1012	25	None	53	Human	Functional	pAC50	=	4.9	4.9	-7079	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1013	25	None	53	Human	Functional	pAC50	=	4.9	4.9	-7079	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1057	25	None	53	Human	Functional	pAC50	=	4.9	4.9	-7079	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	5757	25	None	53	Human	Functional	pAC50	=	4.9	4.9	-7079	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	CHEMBL135	25	None	53	Human	Functional	pAC50	=	4.9	4.9	-7079	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	DB00783	25	None	53	Human	Functional	pAC50	=	4.9	4.9	-7079	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1224	1432	None	51	Human	Functional	pAC50	=	4.9	4.9	-707	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1432	None	51	Human	Functional	pAC50	=	4.9	4.9	-707	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100.0	1432	None	51	Human	Functional	pAC50	=	4.9	4.9	-707	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1432	None	51	Human	Functional	pAC50	=	4.9	4.9	-707	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1432	None	51	Human	Functional	pAC50	=	4.9	4.9	-707	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1432	None	51	Human	Functional	pAC50	=	4.9	4.9	-707	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1432	None	51	Human	Functional	pAC50	=	4.9	4.9	-707	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	202	1508	None	46	Human	Functional	pAC50	=	4.9	4.9	-8	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1508	None	46	Human	Functional	pAC50	=	4.9	4.9	-8	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1508	None	46	Human	Functional	pAC50	=	4.9	4.9	-8	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1508	None	46	Human	Functional	pAC50	=	4.9	4.9	-8	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1508	None	46	Human	Functional	pAC50	=	4.9	4.9	-8	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	2419	3463	None	53	Human	Functional	pAC50	=	4.9	4.9	-21379	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3463	None	53	Human	Functional	pAC50	=	4.9	4.9	-21379	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152.0	3463	None	53	Human	Functional	pAC50	=	4.9	4.9	-21379	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3463	None	53	Human	Functional	pAC50	=	4.9	4.9	-21379	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3463	None	53	Human	Functional	pAC50	=	4.9	4.9	-21379	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3463	None	53	Human	Functional	pAC50	=	4.9	4.9	-21379	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5077	3578	None	61	Human	Functional	pAC50	=	4.9	4.9	-457	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3578	None	61	Human	Functional	pAC50	=	4.9	4.9	-457	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3578	None	61	Human	Functional	pAC50	=	4.9	4.9	-457	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767.0	3578	None	61	Human	Functional	pAC50	=	4.9	4.9	-457	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3578	None	61	Human	Functional	pAC50	=	4.9	4.9	-457	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3578	None	61	Human	Functional	pAC50	=	4.9	4.9	-457	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	2855	4132	None	63	Human	Functional	pAC50	=	4.9	4.9	-6025	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4132	None	63	Human	Functional	pAC50	=	4.9	4.9	-6025	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4132	None	63	Human	Functional	pAC50	=	4.9	4.9	-6025	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717.0	4132	None	63	Human	Functional	pAC50	=	4.9	4.9	-6025	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4132	None	63	Human	Functional	pAC50	=	4.9	4.9	-6025	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4132	None	63	Human	Functional	pAC50	=	4.9	4.9	-6025	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5029	15552	None	54	Human	Functional	pAC50	=	4.9	4.9	-6	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	CHEMBL1219	15552	None	54	Human	Functional	pAC50	=	4.9	4.9	-6	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	2162	41527	None	58	Human	Functional	pAC50	=	4.9	4.9	-6	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41527	None	58	Human	Functional	pAC50	=	4.9	4.9	-6	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	47510	172649	None	27	Human	Functional	pAC50	=	4.9	4.9	-7	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	CHEMBL448416	172649	None	27	Human	Functional	pAC50	=	4.9	4.9	-7	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	22323	15305	None	29	Human	Functional	pAC50	=	4.9	4.9	-6	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15305	None	29	Human	Functional	pAC50	=	4.9	4.9	-6	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15305	None	29	Human	Functional	pAC50	=	4.9	4.9	-6	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2895	206050	None	27	Human	Functional	pAC50	=	5.9	5.9	-60	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2895.0	206050	None	27	Human	Functional	pAC50	=	5.9	5.9	-60	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	206050	None	27	Human	Functional	pAC50	=	5.9	5.9	-60	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	DB00924	206050	None	27	Human	Functional	pAC50	=	5.9	5.9	-60	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2713	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	207729	None	57	Human	Functional	pAC50	=	5.9	5.9	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2543	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-1023	14	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-1023	14	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358.0	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-1023	14	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-1023	14	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-1023	14	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3707	None	46	Human	Functional	pAC50	=	4.9	4.9	-1023	14	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	443955	206828	None	60	Human	Functional	pAC50	=	4.9	4.9	-11	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	206828	None	60	Human	Functional	pAC50	=	4.9	4.9	-11	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	5357	98790	None	31	Human	Functional	pAC50	=	5.9	5.9	-117	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL277945	98790	None	31	Human	Functional	pAC50	=	5.9	5.9	-117	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	16351	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-208	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	16351.0	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-208	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-208	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB13256	102785	None	36	Human	Functional	pAC50	=	5.9	5.9	-208	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	57469	18873	None	78	Human	Functional	pAC50	=	4.9	4.9	-10	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18873	None	78	Human	Functional	pAC50	=	4.9	4.9	-10	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	2286	3183	None	36	Human	Functional	pAC50	=	5.9	5.9	-40	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3183	None	36	Human	Functional	pAC50	=	5.9	5.9	-40	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927.0	3183	None	36	Human	Functional	pAC50	=	5.9	5.9	-40	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3183	None	36	Human	Functional	pAC50	=	5.9	5.9	-40	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3183	None	36	Human	Functional	pAC50	=	5.9	5.9	-40	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3183	None	36	Human	Functional	pAC50	=	5.9	5.9	-40	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2393	3334	None	46	Human	Functional	pAC50	=	4.9	4.9	-1096	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3334	None	46	Human	Functional	pAC50	=	4.9	4.9	-1096	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078.0	3334	None	46	Human	Functional	pAC50	=	4.9	4.9	-1096	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3334	None	46	Human	Functional	pAC50	=	4.9	4.9	-1096	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3334	None	46	Human	Functional	pAC50	=	4.9	4.9	-1096	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3334	None	46	Human	Functional	pAC50	=	4.9	4.9	-1096	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.9	4.9	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	104850	3330	None	58	Human	Functional	pAC50	=	4.9	4.9	-1288	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3330	None	58	Human	Functional	pAC50	=	4.9	4.9	-1288	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3330	None	58	Human	Functional	pAC50	=	4.9	4.9	-1288	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3330	None	58	Human	Functional	pAC50	=	4.9	4.9	-1288	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3330	None	58	Human	Functional	pAC50	=	4.9	4.9	-1288	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	1056	3371	None	67	Human	Functional	pAC50	=	4.9	4.9	-25	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3371	None	67	Human	Functional	pAC50	=	4.9	4.9	-25	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3371	None	67	Human	Functional	pAC50	=	4.9	4.9	-25	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3371	None	67	Human	Functional	pAC50	=	4.9	4.9	-25	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3371	None	67	Human	Functional	pAC50	=	4.9	4.9	-25	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	24776445	3997	None	65	Human	Functional	pAC50	=	4.9	4.9	-1778	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	24776445.0	3997	None	65	Human	Functional	pAC50	=	4.9	4.9	-1778	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	4227	3997	None	65	Human	Functional	pAC50	=	4.9	4.9	-1778	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	6975	3997	None	65	Human	Functional	pAC50	=	4.9	4.9	-1778	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	CHEMBL473417	3997	None	65	Human	Functional	pAC50	=	4.9	4.9	-1778	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	DB08828	3997	None	65	Human	Functional	pAC50	=	4.9	4.9	-1778	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	3081361	93987	None	66	Human	Functional	pAC50	=	4.9	4.9	-22	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93987	None	66	Human	Functional	pAC50	=	4.9	4.9	-22	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	2372	106524	None	30	Human	Functional	pAC50	=	4.9	4.9	-537	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106524	None	30	Human	Functional	pAC50	=	4.9	4.9	-537	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	71731823	111768	None	45	Human	Functional	pAC50	=	4.9	4.9	-11	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	CHEMBL3286830	111768	None	45	Human	Functional	pAC50	=	4.9	4.9	-11	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	3074	17965	None	17	Human	Functional	pAC50	=	4.8	4.8	-12	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL126075	17965	None	17	Human	Functional	pAC50	=	4.8	4.8	-12	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL508338	189074	None	0	Human	Functional	pAC50	=	4.8	4.8	-218	15	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	2105	3054	None	28	Human	Functional	pAC50	=	7.8	7.8	-3	25	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3054	None	28	Human	Functional	pAC50	=	7.8	7.8	-3	25	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3054	None	28	Human	Functional	pAC50	=	7.8	7.8	-3	25	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3054	None	28	Human	Functional	pAC50	=	7.8	7.8	-3	25	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3054	None	28	Human	Functional	pAC50	=	7.8	7.8	-3	25	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	11658860	2344	None	24	Human	Functional	pAC50	=	6.8	6.8	-35	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2344	None	24	Human	Functional	pAC50	=	6.8	6.8	-35	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2344	None	24	Human	Functional	pAC50	=	6.8	6.8	-35	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2344	None	24	Human	Functional	pAC50	=	6.8	6.8	-35	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2344	None	24	Human	Functional	pAC50	=	6.8	6.8	-35	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	124087	1389	None	72	Human	Functional	pAC50	=	6.8	6.8	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	124087.0	1389	None	72	Human	Functional	pAC50	=	6.8	6.8	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1389	None	72	Human	Functional	pAC50	=	6.8	6.8	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1389	None	72	Human	Functional	pAC50	=	6.8	6.8	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1389	None	72	Human	Functional	pAC50	=	6.8	6.8	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1389	None	72	Human	Functional	pAC50	=	6.8	6.8	-1	27	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2165	206241	None	47	Human	Functional	pAC50	=	5.8	5.8	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	206241	None	47	Human	Functional	pAC50	=	5.8	5.8	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	206241	None	47	Human	Functional	pAC50	=	5.8	5.8	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3108	209745	None	64	Human	Functional	pAC50	=	4.8	4.8	-7	7	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	209745	None	64	Human	Functional	pAC50	=	4.8	4.8	-7	7	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	1209	1658	None	52	Human	Functional	pAC50	=	4.8	4.8	-56	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1658	None	52	Human	Functional	pAC50	=	4.8	4.8	-56	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1658	None	52	Human	Functional	pAC50	=	4.8	4.8	-56	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1658	None	52	Human	Functional	pAC50	=	4.8	4.8	-56	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1658	None	52	Human	Functional	pAC50	=	4.8	4.8	-56	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	260	3869	None	33	Human	Functional	pAC50	=	4.8	4.8	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2775	3869	None	33	Human	Functional	pAC50	=	4.8	4.8	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	656665	3869	None	33	Human	Functional	pAC50	=	4.8	4.8	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL56564	3869	None	33	Human	Functional	pAC50	=	4.8	4.8	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB11699	3869	None	33	Human	Functional	pAC50	=	4.8	4.8	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	4497	34413	None	64	Human	Functional	pAC50	=	4.8	4.8	-9	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL1428	34413	None	64	Human	Functional	pAC50	=	4.8	4.8	-9	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	3823	50235	None	31	Human	Functional	pAC50	=	4.8	4.8	-38	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	76973198	50235	None	31	Human	Functional	pAC50	=	4.8	4.8	-38	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL157101	50235	None	31	Human	Functional	pAC50	=	4.8	4.8	-38	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	10831	117027	None	19	Human	Functional	pAC50	=	4.8	4.8	-3	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL338667	117027	None	19	Human	Functional	pAC50	=	4.8	4.8	-3	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	3488	179242	None	69	Human	Functional	pAC50	=	4.8	4.8	-120	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL472	179242	None	69	Human	Functional	pAC50	=	4.8	4.8	-120	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	636403	188375	None	19	Human	Functional	pAC50	=	4.8	4.8	-6	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188375	None	19	Human	Functional	pAC50	=	4.8	4.8	-6	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	31703	194829	None	40	Human	Functional	pAC50	=	4.8	4.8	-23	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194829	None	40	Human	Functional	pAC50	=	4.8	4.8	-23	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194829	None	40	Human	Functional	pAC50	=	4.8	4.8	-23	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	2333	142422	None	66	Human	Functional	pAC50	=	5.8	5.8	-1	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142422	None	66	Human	Functional	pAC50	=	5.8	5.8	-1	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2169	44861	None	29	Human	Functional	pAC50	=	5.8	5.8	-26	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44861	None	29	Human	Functional	pAC50	=	5.8	5.8	-26	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	5453	206077	None	58	Human	Functional	pAC50	=	5.8	5.8	-36	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	206077	None	58	Human	Functional	pAC50	=	5.8	5.8	-36	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	19861	209982	None	33	Human	Functional	pAC50	=	5.8	5.8	-75	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	19861.0	209982	None	33	Human	Functional	pAC50	=	5.8	5.8	-75	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	209982	None	33	Human	Functional	pAC50	=	5.8	5.8	-75	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	DB00719	209982	None	33	Human	Functional	pAC50	=	5.8	5.8	-75	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	137	370	None	37	Human	Functional	pAC50	=	4.8	4.8	-7244	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	370	None	37	Human	Functional	pAC50	=	4.8	4.8	-7244	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	370	None	37	Human	Functional	pAC50	=	4.8	4.8	-7244	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	370	None	37	Human	Functional	pAC50	=	4.8	4.8	-7244	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	370	None	37	Human	Functional	pAC50	=	4.8	4.8	-7244	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	370	None	37	Human	Functional	pAC50	=	4.8	4.8	-7244	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2541	786	None	65	Human	Functional	pAC50	=	4.8	4.8	-8511	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	2541.0	786	None	65	Human	Functional	pAC50	=	4.8	4.8	-8511	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	587	786	None	65	Human	Functional	pAC50	=	4.8	4.8	-8511	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	6907	786	None	65	Human	Functional	pAC50	=	4.8	4.8	-8511	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1016	786	None	65	Human	Functional	pAC50	=	4.8	4.8	-8511	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB00796	786	None	65	Human	Functional	pAC50	=	4.8	4.8	-8511	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB13919	786	None	65	Human	Functional	pAC50	=	4.8	4.8	-8511	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	4942	5720	None	27	Human	Functional	pAC50	=	4.8	4.8	-19	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4942.0	5720	None	27	Human	Functional	pAC50	=	4.8	4.8	-19	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5720	None	27	Human	Functional	pAC50	=	4.8	4.8	-19	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB12278	5720	None	27	Human	Functional	pAC50	=	4.8	4.8	-19	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	10102	2546	None	55	Human	Functional	pAC50	=	4.8	4.8	-1548	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	1824	2546	None	55	Human	Functional	pAC50	=	4.8	4.8	-1548	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	65906	2546	None	55	Human	Functional	pAC50	=	4.8	4.8	-1548	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	65906.0	2546	None	55	Human	Functional	pAC50	=	4.8	4.8	-1548	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	CHEMBL94454	2546	None	55	Human	Functional	pAC50	=	4.8	4.8	-1548	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	DB12523	2546	None	55	Human	Functional	pAC50	=	4.8	4.8	-1548	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	41684	31229	None	62	Human	Functional	pAC50	=	4.8	4.8	-38	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31229	None	62	Human	Functional	pAC50	=	4.8	4.8	-38	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4499	59795	None	61	Human	Functional	pAC50	=	4.8	4.8	-8	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL1726	59795	None	61	Human	Functional	pAC50	=	4.8	4.8	-8	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	37367	8653	None	9	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1095282	8653	None	9	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	11954369	189192	None	17	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	CHEMBL509924	189192	None	17	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	5991	206377	None	46	Human	Functional	pAC50	=	4.8	4.8	-3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL691	206377	None	46	Human	Functional	pAC50	=	4.8	4.8	-3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	4760	206707	None	55	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL711	206707	None	55	Human	Functional	pAC50	=	4.8	4.8	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	4452	2762	None	13	Human	Functional	pAC50	=	6.8	6.8	-107	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2762	None	13	Human	Functional	pAC50	=	6.8	6.8	-107	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2762	None	13	Human	Functional	pAC50	=	6.8	6.8	-107	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	3294	2006	None	61	Human	Functional	pAC50	=	5.8	5.8	-1862	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	2006	None	61	Human	Functional	pAC50	=	5.8	5.8	-1862	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360.0	2006	None	61	Human	Functional	pAC50	=	5.8	5.8	-1862	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	2006	None	61	Human	Functional	pAC50	=	5.8	5.8	-1862	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	2006	None	61	Human	Functional	pAC50	=	5.8	5.8	-1862	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	2006	None	61	Human	Functional	pAC50	=	5.8	5.8	-1862	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	214	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-26	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-26	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-26	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566.0	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-26	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-26	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-26	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3860	None	43	Human	Functional	pAC50	=	5.7	5.7	-26	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	37	778	None	41	Human	Functional	pAC50	=	6.7	6.7	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	None	41	Human	Functional	pAC50	=	6.7	6.7	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	None	41	Human	Functional	pAC50	=	6.7	6.7	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746.0	778	None	41	Human	Functional	pAC50	=	6.7	6.7	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	None	41	Human	Functional	pAC50	=	6.7	6.7	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	None	41	Human	Functional	pAC50	=	6.7	6.7	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	57469	18873	None	78	Human	Functional	pAC50	=	4.7	4.7	-10	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18873	None	78	Human	Functional	pAC50	=	4.7	4.7	-10	6	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	46220502	112646	None	60	Human	Functional	pAC50	=	4.7	4.7	-61	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL3301610	112646	None	60	Human	Functional	pAC50	=	4.7	4.7	-61	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	44112	121354	None	36	Human	Functional	pAC50	=	4.7	4.7	-478	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121354	None	36	Human	Functional	pAC50	=	4.7	4.7	-478	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	2099	9309	None	36	Human	Functional	pAC50	=	6.7	6.7	52	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1110	9309	None	36	Human	Functional	pAC50	=	6.7	6.7	52	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	68867	78202	None	29	Human	Functional	pAC50	=	6.7	6.7	1	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	68867.0	78202	None	29	Human	Functional	pAC50	=	6.7	6.7	1	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78202	None	29	Human	Functional	pAC50	=	6.7	6.7	1	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	DB08810	78202	None	29	Human	Functional	pAC50	=	6.7	6.7	1	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	43815	187026	None	38	Human	Functional	pAC50	=	4.7	4.7	-125	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	187026	None	38	Human	Functional	pAC50	=	4.7	4.7	-125	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	187026	None	38	Human	Functional	pAC50	=	4.7	4.7	-125	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	60606	61580	None	50	Human	Functional	pAC50	=	5.7	5.7	1	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	60606.0	61580	None	50	Human	Functional	pAC50	=	5.7	5.7	1	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61580	None	50	Human	Functional	pAC50	=	5.7	5.7	1	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	DB00758	61580	None	50	Human	Functional	pAC50	=	5.7	5.7	1	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	5591	157623	None	57	Human	Functional	pAC50	=	5.7	5.7	1	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157623	None	57	Human	Functional	pAC50	=	5.7	5.7	1	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-33	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-33	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-33	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.7	4.7	-33	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	108000	56869	None	26	Human	Functional	pAC50	=	4.7	4.7	-58	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	135418340	56869	None	26	Human	Functional	pAC50	=	4.7	4.7	-58	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1643895	56869	None	26	Human	Functional	pAC50	=	4.7	4.7	-58	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	445643	97442	None	46	Human	Functional	pAC50	=	4.7	4.7	-2	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97442	None	46	Human	Functional	pAC50	=	4.7	4.7	-2	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	5639	98949	None	48	Human	Functional	pAC50	=	4.7	4.7	-398	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98949	None	48	Human	Functional	pAC50	=	4.7	4.7	-398	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	198	313	None	72	Human	Functional	pAC50	=	5.7	5.7	-724	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	82148	313	None	72	Human	Functional	pAC50	=	5.7	5.7	-724	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	82148.0	313	None	72	Human	Functional	pAC50	=	5.7	5.7	-724	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	99	313	None	72	Human	Functional	pAC50	=	5.7	5.7	-724	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	CHEMBL10878	313	None	72	Human	Functional	pAC50	=	5.7	5.7	-724	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	DB06594	313	None	72	Human	Functional	pAC50	=	5.7	5.7	-724	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	2726	919	None	48	Human	Functional	pAC50	=	5.7	5.7	-134	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2726.0	919	None	48	Human	Functional	pAC50	=	5.7	5.7	-134	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	919	None	48	Human	Functional	pAC50	=	5.7	5.7	-134	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	919	None	48	Human	Functional	pAC50	=	5.7	5.7	-134	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	919	None	48	Human	Functional	pAC50	=	5.7	5.7	-134	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	919	None	48	Human	Functional	pAC50	=	5.7	5.7	-134	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2473	163278	None	34	Human	Functional	pAC50	=	4.7	4.7	-2454	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	CHEMBL418134	163278	None	34	Human	Functional	pAC50	=	4.7	4.7	-2454	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	168871	89164	None	10	Human	Functional	pAC50	=	4.7	4.7	-630	13	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89164	None	10	Human	Functional	pAC50	=	4.7	4.7	-630	13	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	3752	27039	None	53	Human	Functional	pAC50	=	4.7	4.7	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	CHEMBL136497	27039	None	53	Human	Functional	pAC50	=	4.7	4.7	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	6010	30706	None	19	Human	Functional	pAC50	=	4.7	4.7	1	2	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	CHEMBL1395	30706	None	19	Human	Functional	pAC50	=	4.7	4.7	1	2	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	146570	43468	None	43	Human	Functional	pAC50	=	4.7	4.7	-6	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1508	43468	None	43	Human	Functional	pAC50	=	4.7	4.7	-6	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1400	1957	None	46	Human	Functional	pAC50	=	5.7	5.7	-4	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1957	None	46	Human	Functional	pAC50	=	5.7	5.7	-4	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658.0	1957	None	46	Human	Functional	pAC50	=	5.7	5.7	-4	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1957	None	46	Human	Functional	pAC50	=	5.7	5.7	-4	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1957	None	46	Human	Functional	pAC50	=	5.7	5.7	-4	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1957	None	46	Human	Functional	pAC50	=	5.7	5.7	-4	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1957	None	46	Human	Functional	pAC50	=	5.7	5.7	-4	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	4150	788	None	26	Human	Functional	pAC50	=	5.6	5.6	-35	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	788	None	26	Human	Functional	pAC50	=	5.6	5.6	-35	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	788	None	26	Human	Functional	pAC50	=	5.6	5.6	-35	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019.0	788	None	26	Human	Functional	pAC50	=	5.6	5.6	-35	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	788	None	26	Human	Functional	pAC50	=	5.6	5.6	-35	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	788	None	26	Human	Functional	pAC50	=	5.6	5.6	-35	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	2865	4143	None	47	Human	Functional	pAC50	=	6.6	6.6	-23	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4143	None	47	Human	Functional	pAC50	=	6.6	6.6	-23	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4143	None	47	Human	Functional	pAC50	=	6.6	6.6	-23	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854.0	4143	None	47	Human	Functional	pAC50	=	6.6	6.6	-23	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4143	None	47	Human	Functional	pAC50	=	6.6	6.6	-23	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4143	None	47	Human	Functional	pAC50	=	6.6	6.6	-23	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	4940	14476	None	26	Human	Functional	pAC50	=	6.6	6.6	-7	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14476	None	26	Human	Functional	pAC50	=	6.6	6.6	-7	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	2202	3132	None	63	Human	Functional	pAC50	=	5.6	5.6	-38	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3132	None	63	Human	Functional	pAC50	=	5.6	5.6	-38	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850.0	3132	None	63	Human	Functional	pAC50	=	5.6	5.6	-38	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3132	None	63	Human	Functional	pAC50	=	5.6	5.6	-38	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3132	None	63	Human	Functional	pAC50	=	5.6	5.6	-38	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3132	None	63	Human	Functional	pAC50	=	5.6	5.6	-38	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	3689	102826	None	36	Human	Functional	pAC50	=	5.6	5.6	-331	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102826	None	36	Human	Functional	pAC50	=	5.6	5.6	-331	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102826	None	36	Human	Functional	pAC50	=	5.6	5.6	-331	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	4762	14475	None	14	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201208	14475	None	14	Human	Functional	pAC50	=	4.6	4.6	-1	2	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	445643	97442	None	46	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97442	None	46	Human	Functional	pAC50	=	4.6	4.6	-2	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	53232	188732	None	57	Human	Functional	pAC50	=	4.6	4.6	-3548	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL503	188732	None	57	Human	Functional	pAC50	=	4.6	4.6	-3548	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	448537	160344	None	54	Human	Functional	pAC50	=	4.6	4.6	-28	31	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160344	None	54	Human	Functional	pAC50	=	4.6	4.6	-28	31	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	4756	16656	None	34	Human	Functional	pAC50	=	4.6	4.6	-12	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1201022	16656	None	34	Human	Functional	pAC50	=	4.6	4.6	-12	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1242	16656	None	34	Human	Functional	pAC50	=	4.6	4.6	-12	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	27812	67012	None	31	Human	Functional	pAC50	=	4.6	4.6	-2	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1868702	67012	None	31	Human	Functional	pAC50	=	4.6	4.6	-2	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	1153	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341.0	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1628	None	36	Human	Functional	pAC50	=	6.6	6.6	-28	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	150	2509	None	14	Human	Functional	pAC50	=	7.6	7.6	-2	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2509	None	14	Human	Functional	pAC50	=	7.6	7.6	-2	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2509	None	14	Human	Functional	pAC50	=	7.6	7.6	-2	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226.0	2509	None	14	Human	Functional	pAC50	=	7.6	7.6	-2	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2509	None	14	Human	Functional	pAC50	=	7.6	7.6	-2	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2509	None	14	Human	Functional	pAC50	=	7.6	7.6	-2	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-165	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-165	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-165	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-165	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-165	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	4.6	4.6	-165	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	4046	2483	None	21	Human	Functional	pAC50	=	4.6	4.6	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2483	None	21	Human	Functional	pAC50	=	4.6	4.6	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2483	None	21	Human	Functional	pAC50	=	4.6	4.6	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2483	None	21	Human	Functional	pAC50	=	4.6	4.6	-33	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	10007	14490	None	22	Human	Functional	pAC50	=	4.6	4.6	1	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201269	14490	None	22	Human	Functional	pAC50	=	4.6	4.6	1	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	54841	205585	None	33	Human	Functional	pAC50	=	4.6	4.6	-14	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL641	205585	None	33	Human	Functional	pAC50	=	4.6	4.6	-14	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	1201549	597	None	17	Human	Functional	pAC50	=	5.6	5.6	-208	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	1201549.0	597	None	17	Human	Functional	pAC50	=	5.6	5.6	-208	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	597	None	17	Human	Functional	pAC50	=	5.6	5.6	-208	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	597	None	17	Human	Functional	pAC50	=	5.6	5.6	-208	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	597	None	17	Human	Functional	pAC50	=	5.6	5.6	-208	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	597	None	17	Human	Functional	pAC50	=	5.6	5.6	-208	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	597	None	17	Human	Functional	pAC50	=	5.6	5.6	-208	26	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	68873	43578	None	39	Human	Functional	pAC50	=	4.6	4.6	-2	3	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43578	None	39	Human	Functional	pAC50	=	4.6	4.6	-2	3	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	319	1324	None	32	Human	Functional	pAC50	=	4.6	4.6	-8317	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1324	None	32	Human	Functional	pAC50	=	4.6	4.6	-8317	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1324	None	32	Human	Functional	pAC50	=	4.6	4.6	-8317	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031.0	1324	None	32	Human	Functional	pAC50	=	4.6	4.6	-8317	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1324	None	32	Human	Functional	pAC50	=	4.6	4.6	-8317	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1324	None	32	Human	Functional	pAC50	=	4.6	4.6	-8317	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1324	None	32	Human	Functional	pAC50	=	4.6	4.6	-8317	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	4209	3163	None	48	Human	Functional	pAC50	=	4.6	4.6	-22387	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3163	None	48	Human	Functional	pAC50	=	4.6	4.6	-22387	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893.0	3163	None	48	Human	Functional	pAC50	=	4.6	4.6	-22387	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3163	None	48	Human	Functional	pAC50	=	4.6	4.6	-22387	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3163	None	48	Human	Functional	pAC50	=	4.6	4.6	-22387	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3163	None	48	Human	Functional	pAC50	=	4.6	4.6	-22387	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3163	None	48	Human	Functional	pAC50	=	4.6	4.6	-22387	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL508338	189074	None	0	Human	Functional	pAC50	=	4.6	4.6	-218	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	8730	198347	None	44	Human	Functional	pAC50	=	4.6	4.6	-5	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	90657408	198347	None	44	Human	Functional	pAC50	=	4.6	4.6	-5	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL559	198347	None	44	Human	Functional	pAC50	=	4.6	4.6	-5	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	4612	208438	None	30	Human	Functional	pAC50	=	4.6	4.6	-3	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	CHEMBL847	208438	None	30	Human	Functional	pAC50	=	4.6	4.6	-3	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	102	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-16	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-16	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-16	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969.0	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-16	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-16	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4127	None	36	Human	Functional	pAC50	=	6.6	6.6	-16	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	26987	949	None	27	Human	Functional	pAC50	=	5.6	5.6	-263	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	26987.0	949	None	27	Human	Functional	pAC50	=	5.6	5.6	-263	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	949	None	27	Human	Functional	pAC50	=	5.6	5.6	-263	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	949	None	27	Human	Functional	pAC50	=	5.6	5.6	-263	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	949	None	27	Human	Functional	pAC50	=	5.6	5.6	-263	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	949	None	27	Human	Functional	pAC50	=	5.6	5.6	-263	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	21722	17999	None	26	Human	Functional	pAC50	=	5.6	5.6	-2	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17999	None	26	Human	Functional	pAC50	=	5.6	5.6	-2	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	4450	178333	None	41	Human	Functional	pAC50	=	5.6	5.6	-4	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178333	None	41	Human	Functional	pAC50	=	5.6	5.6	-4	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	100	3805	None	44	Human	Functional	pAC50	=	5.6	5.6	-125	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3805	None	44	Human	Functional	pAC50	=	5.6	5.6	-125	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3805	None	44	Human	Functional	pAC50	=	5.6	5.6	-125	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3805	None	44	Human	Functional	pAC50	=	5.6	5.6	-125	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3805	None	44	Human	Functional	pAC50	=	5.6	5.6	-125	38	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	124	2981	None	32	Human	Functional	pAC50	=	6.6	6.6	-457	24	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2981	None	32	Human	Functional	pAC50	=	6.6	6.6	-457	24	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2981	None	32	Human	Functional	pAC50	=	6.6	6.6	-457	24	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636.0	2981	None	32	Human	Functional	pAC50	=	6.6	6.6	-457	24	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2981	None	32	Human	Functional	pAC50	=	6.6	6.6	-457	24	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2981	None	32	Human	Functional	pAC50	=	6.6	6.6	-457	24	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2995	206863	None	31	Human	Functional	pAC50	=	4.6	4.6	-154	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2995.0	206863	None	31	Human	Functional	pAC50	=	4.6	4.6	-154	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	206863	None	31	Human	Functional	pAC50	=	4.6	4.6	-154	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	206863	None	31	Human	Functional	pAC50	=	4.6	4.6	-154	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	DB01151	206863	None	31	Human	Functional	pAC50	=	4.6	4.6	-154	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2220	3134	None	58	Human	Functional	pAC50	=	7.6	7.6	-10	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3134	None	58	Human	Functional	pAC50	=	7.6	7.6	-10	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400.0	3134	None	58	Human	Functional	pAC50	=	7.6	7.6	-10	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3134	None	58	Human	Functional	pAC50	=	7.6	7.6	-10	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3134	None	58	Human	Functional	pAC50	=	7.6	7.6	-10	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3134	None	58	Human	Functional	pAC50	=	7.6	7.6	-10	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	11626560	203394	None	56	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	203394	None	56	Human	Functional	pAC50	=	5.6	5.6	1	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	213	3853	None	34	Human	Functional	pAC50	=	6.6	6.6	-4	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3853	None	34	Human	Functional	pAC50	=	6.6	6.6	-4	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3853	None	34	Human	Functional	pAC50	=	6.6	6.6	-4	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533.0	3853	None	34	Human	Functional	pAC50	=	6.6	6.6	-4	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3853	None	34	Human	Functional	pAC50	=	6.6	6.6	-4	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3853	None	34	Human	Functional	pAC50	=	6.6	6.6	-4	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2402	3370	None	38	Human	Functional	pAC50	=	5.6	5.6	-512	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3370	None	38	Human	Functional	pAC50	=	5.6	5.6	-512	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095.0	3370	None	38	Human	Functional	pAC50	=	5.6	5.6	-512	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3370	None	38	Human	Functional	pAC50	=	5.6	5.6	-512	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3370	None	38	Human	Functional	pAC50	=	5.6	5.6	-512	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3370	None	38	Human	Functional	pAC50	=	5.6	5.6	-512	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10531	1420	None	13	Human	Functional	pAC50	=	5.6	5.6	-100	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	10531.0	1420	None	13	Human	Functional	pAC50	=	5.6	5.6	-100	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1420	None	13	Human	Functional	pAC50	=	5.6	5.6	-100	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1420	None	13	Human	Functional	pAC50	=	5.6	5.6	-100	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1420	None	13	Human	Functional	pAC50	=	5.6	5.6	-100	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1420	None	13	Human	Functional	pAC50	=	5.6	5.6	-100	29	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2274	3173	None	38	Human	Functional	pAC50	=	5.6	5.6	-35	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3173	None	38	Human	Functional	pAC50	=	5.6	5.6	-35	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917.0	3173	None	38	Human	Functional	pAC50	=	5.6	5.6	-35	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3173	None	38	Human	Functional	pAC50	=	5.6	5.6	-35	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3173	None	38	Human	Functional	pAC50	=	5.6	5.6	-35	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3173	None	38	Human	Functional	pAC50	=	5.6	5.6	-35	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3926	209699	None	30	Human	Functional	pAC50	=	5.6	5.6	-4	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	209699	None	30	Human	Functional	pAC50	=	5.6	5.6	-4	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	25271887	5162	None	41	Human	Functional	pAC50	=	4.6	4.6	-7	2	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	5486971	5162	None	41	Human	Functional	pAC50	=	4.6	4.6	-7	2	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1059	5162	None	41	Human	Functional	pAC50	=	4.6	4.6	-7	2	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	2351	4301	None	35	Human	Functional	pAC50	=	4.6	4.6	-12	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4301	None	35	Human	Functional	pAC50	=	4.6	4.6	-12	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4301	None	35	Human	Functional	pAC50	=	4.6	4.6	-12	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	50922675	112647	None	47	Human	Functional	pAC50	=	4.6	4.6	-3	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	CHEMBL3301612	112647	None	47	Human	Functional	pAC50	=	4.6	4.6	-3	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	154257	178724	None	43	Human	Functional	pAC50	=	5.5	5.5	-6	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178724	None	43	Human	Functional	pAC50	=	5.5	5.5	-6	19	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	6127	14505	None	4	Human	Functional	pAC50	=	4.5	4.5	-177	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	6127.0	14505	None	4	Human	Functional	pAC50	=	4.5	4.5	-177	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14505	None	4	Human	Functional	pAC50	=	4.5	4.5	-177	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13720	14505	None	4	Human	Functional	pAC50	=	4.5	4.5	-177	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	5833	30492	None	42	Human	Functional	pAC50	=	4.5	4.5	-2	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30492	None	42	Human	Functional	pAC50	=	4.5	4.5	-2	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	4413	98126	None	43	Human	Functional	pAC50	=	4.5	4.5	-9	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98126	None	43	Human	Functional	pAC50	=	4.5	4.5	-9	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	5467	208386	None	26	Human	Functional	pAC50	=	4.5	4.5	-46	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	5467.0	208386	None	26	Human	Functional	pAC50	=	4.5	4.5	-46	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL84158	208386	None	26	Human	Functional	pAC50	=	4.5	4.5	-46	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	DB13025	208386	None	26	Human	Functional	pAC50	=	4.5	4.5	-46	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	5732	209393	None	28	Human	Functional	pAC50	=	4.5	4.5	-138	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL911	209393	None	28	Human	Functional	pAC50	=	4.5	4.5	-138	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	37	778	None	41	Human	Functional	pAC50	=	8.5	8.5	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	778	None	41	Human	Functional	pAC50	=	8.5	8.5	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	778	None	41	Human	Functional	pAC50	=	8.5	8.5	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746.0	778	None	41	Human	Functional	pAC50	=	8.5	8.5	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	778	None	41	Human	Functional	pAC50	=	8.5	8.5	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	778	None	41	Human	Functional	pAC50	=	8.5	8.5	-3	12	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	135	2532	None	33	Human	Functional	pAC50	=	7.5	7.5	-5	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2532	None	33	Human	Functional	pAC50	=	7.5	7.5	-5	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2532	None	33	Human	Functional	pAC50	=	7.5	7.5	-5	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184.0	2532	None	33	Human	Functional	pAC50	=	7.5	7.5	-5	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2532	None	33	Human	Functional	pAC50	=	7.5	7.5	-5	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2532	None	33	Human	Functional	pAC50	=	7.5	7.5	-5	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	168871	89164	None	10	Human	Functional	pAC50	=	5.5	5.5	-630	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89164	None	10	Human	Functional	pAC50	=	5.5	5.5	-630	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	242	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-33	33	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-33	33	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-33	33	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795.0	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-33	33	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-33	33	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	470	None	70	Human	Functional	pAC50	=	6.5	6.5	-33	33	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	54477	84687	None	24	Human	Functional	pAC50	=	5.5	5.5	-33	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	CHEMBL22242	84687	None	24	Human	Functional	pAC50	=	5.5	5.5	-33	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	72093	35070	None	5	Human	Functional	pAC50	=	5.5	5.5	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35070	None	5	Human	Functional	pAC50	=	5.5	5.5	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35070	None	5	Human	Functional	pAC50	=	5.5	5.5	-2	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4066	207084	None	54	Human	Functional	pAC50	=	5.5	5.5	-194	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	4066.0	207084	None	54	Human	Functional	pAC50	=	5.5	5.5	-194	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	207084	None	54	Human	Functional	pAC50	=	5.5	5.5	-194	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	DB01071	207084	None	54	Human	Functional	pAC50	=	5.5	5.5	-194	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2342	599	None	30	Human	Functional	pAC50	=	6.5	6.5	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	599	None	30	Human	Functional	pAC50	=	6.5	6.5	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	599	None	30	Human	Functional	pAC50	=	6.5	6.5	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	599	None	30	Human	Functional	pAC50	=	6.5	6.5	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	599	None	30	Human	Functional	pAC50	=	6.5	6.5	3	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	24826799	10802	None	64	Human	Functional	pAC50	=	5.5	5.5	-10	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10802	None	64	Human	Functional	pAC50	=	5.5	5.5	-10	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	5411	206491	None	57	Human	Functional	pAC50	=	4.5	4.5	-11220	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL698	206491	None	57	Human	Functional	pAC50	=	4.5	4.5	-11220	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	135409453	3773	None	26	Human	Functional	pAC50	=	6.5	6.5	-28	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3773	None	26	Human	Functional	pAC50	=	6.5	6.5	-28	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3773	None	26	Human	Functional	pAC50	=	6.5	6.5	-28	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	1481	2066	None	66	Human	Functional	pAC50	=	4.5	4.5	-38904	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	3749	2066	None	66	Human	Functional	pAC50	=	4.5	4.5	-38904	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	3749.0	2066	None	66	Human	Functional	pAC50	=	4.5	4.5	-38904	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	589	2066	None	66	Human	Functional	pAC50	=	4.5	4.5	-38904	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	6908	2066	None	66	Human	Functional	pAC50	=	4.5	4.5	-38904	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1513	2066	None	66	Human	Functional	pAC50	=	4.5	4.5	-38904	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	DB01029	2066	None	66	Human	Functional	pAC50	=	4.5	4.5	-38904	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	1343	1889	None	43	Human	Functional	pAC50	=	6.5	6.5	-79	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1889	None	43	Human	Functional	pAC50	=	6.5	6.5	-79	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519.0	1889	None	43	Human	Functional	pAC50	=	6.5	6.5	-79	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1889	None	43	Human	Functional	pAC50	=	6.5	6.5	-79	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1889	None	43	Human	Functional	pAC50	=	6.5	6.5	-79	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1889	None	43	Human	Functional	pAC50	=	6.5	6.5	-79	12	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	1440	2027	None	69	Human	Functional	pAC50	=	4.4	4.4	-93	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1909	2027	None	69	Human	Functional	pAC50	=	4.4	4.4	-93	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	3715	2027	None	69	Human	Functional	pAC50	=	4.4	4.4	-93	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL6	2027	None	69	Human	Functional	pAC50	=	4.4	4.4	-93	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB00328	2027	None	69	Human	Functional	pAC50	=	4.4	4.4	-93	7	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	60198	14417	None	47	Human	Functional	pAC50	=	4.4	4.4	-15	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	0	2	4.0	C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)C=CC(=O)C=C12	10.1038/s41467-023-40064-9
	CHEMBL1200374	14417	None	47	Human	Functional	pAC50	=	4.4	4.4	-15	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	0	2	4.0	C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)C=CC(=O)C=C12	10.1038/s41467-023-40064-9
	5284550	41735	None	12	Human	Functional	pAC50	=	5.4	5.4	-190	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	5284550.0	41735	None	12	Human	Functional	pAC50	=	5.4	5.4	-190	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL108947	41735	None	12	Human	Functional	pAC50	=	5.4	5.4	-190	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41735	None	12	Human	Functional	pAC50	=	5.4	5.4	-190	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	DB09167	41735	None	12	Human	Functional	pAC50	=	5.4	5.4	-190	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	240	944	None	25	Human	Functional	pAC50	=	5.4	5.4	-79	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	2769	944	None	25	Human	Functional	pAC50	=	5.4	5.4	-79	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	44279790	944	None	25	Human	Functional	pAC50	=	5.4	5.4	-79	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	660	944	None	25	Human	Functional	pAC50	=	5.4	5.4	-79	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL1729	944	None	25	Human	Functional	pAC50	=	5.4	5.4	-79	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL560739	944	None	25	Human	Functional	pAC50	=	5.4	5.4	-79	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	DB00604	944	None	25	Human	Functional	pAC50	=	5.4	5.4	-79	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	55645	84404	None	3	Human	Functional	pAC50	=	5.4	5.4	-389	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	55645.0	84404	None	3	Human	Functional	pAC50	=	5.4	5.4	-389	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84404	None	3	Human	Functional	pAC50	=	5.4	5.4	-389	11	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	4993	122423	None	61	Human	Functional	pAC50	=	4.4	4.4	-5	5	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122423	None	61	Human	Functional	pAC50	=	4.4	4.4	-5	5	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	54454	5260	None	48	Human	Functional	pAC50	=	5.4	5.4	-1	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5260	None	48	Human	Functional	pAC50	=	5.4	5.4	-1	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	4976	206037	None	20	Human	Functional	pAC50	=	5.4	5.4	-426	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	206037	None	20	Human	Functional	pAC50	=	5.4	5.4	-426	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	134	2514	None	19	Human	Functional	pAC50	=	8.4	8.4	2	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2514	None	19	Human	Functional	pAC50	=	8.4	8.4	2	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2514	None	19	Human	Functional	pAC50	=	8.4	8.4	2	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681.0	2514	None	19	Human	Functional	pAC50	=	8.4	8.4	2	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2514	None	19	Human	Functional	pAC50	=	8.4	8.4	2	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2514	None	19	Human	Functional	pAC50	=	8.4	8.4	2	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	67462786	120581	None	50	Human	Functional	pAC50	=	5.4	5.4	2	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	CHEMBL3545376	120581	None	50	Human	Functional	pAC50	=	5.4	5.4	2	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	2337	3256	None	51	Human	Functional	pAC50	=	5.4	5.4	-11	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3256	None	51	Human	Functional	pAC50	=	5.4	5.4	-11	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3256	None	51	Human	Functional	pAC50	=	5.4	5.4	-11	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002.0	3256	None	51	Human	Functional	pAC50	=	5.4	5.4	-11	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3256	None	51	Human	Functional	pAC50	=	5.4	5.4	-11	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3256	None	51	Human	Functional	pAC50	=	5.4	5.4	-11	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	2407	3372	None	50	Human	Functional	pAC50	=	6.4	6.4	-128	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3372	None	50	Human	Functional	pAC50	=	6.4	6.4	-128	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227.0	3372	None	50	Human	Functional	pAC50	=	6.4	6.4	-128	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3372	None	50	Human	Functional	pAC50	=	6.4	6.4	-128	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3372	None	50	Human	Functional	pAC50	=	6.4	6.4	-128	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3372	None	50	Human	Functional	pAC50	=	6.4	6.4	-128	17	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	1782	2518	None	51	Human	Functional	pAC50	=	5.4	5.4	-45	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	241	2518	None	51	Human	Functional	pAC50	=	5.4	5.4	-45	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	4168	2518	None	51	Human	Functional	pAC50	=	5.4	5.4	-45	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	4168.0	2518	None	51	Human	Functional	pAC50	=	5.4	5.4	-45	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	CHEMBL86	2518	None	51	Human	Functional	pAC50	=	5.4	5.4	-45	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	DB01233	2518	None	51	Human	Functional	pAC50	=	5.4	5.4	-45	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	2600	3779	None	53	Human	Functional	pAC50	=	5.4	5.4	-15	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3779	None	53	Human	Functional	pAC50	=	5.4	5.4	-15	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3779	None	53	Human	Functional	pAC50	=	5.4	5.4	-15	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3779	None	53	Human	Functional	pAC50	=	5.4	5.4	-15	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3779	None	53	Human	Functional	pAC50	=	5.4	5.4	-15	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	392622	56328	None	57	Human	Functional	pAC50	=	5.4	5.4	-3	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56328	None	57	Human	Functional	pAC50	=	5.4	5.4	-3	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	25382	9159	None	27	Human	Functional	pAC50	=	5.4	5.4	-117	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9159	None	27	Human	Functional	pAC50	=	5.4	5.4	-117	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	441243	9838	None	41	Human	Functional	pAC50	=	4.4	4.4	-288	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	CHEMBL114	9838	None	41	Human	Functional	pAC50	=	4.4	4.4	-288	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	3463	175250	None	68	Human	Functional	pAC50	=	5.4	5.4	3	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	250	6	1	2	3.6	Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1	10.1038/s41467-023-40064-9
	CHEMBL457	175250	None	68	Human	Functional	pAC50	=	5.4	5.4	3	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	250	6	1	2	3.6	Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1	10.1038/s41467-023-40064-9
	2389	3331	None	72	Human	Functional	pAC50	=	6.4	6.4	-91	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3331	None	72	Human	Functional	pAC50	=	6.4	6.4	-91	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073.0	3331	None	72	Human	Functional	pAC50	=	6.4	6.4	-91	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3331	None	72	Human	Functional	pAC50	=	6.4	6.4	-91	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3331	None	72	Human	Functional	pAC50	=	6.4	6.4	-91	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3331	None	72	Human	Functional	pAC50	=	6.4	6.4	-91	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	17676	7074	None	25	Human	Functional	pAC50	=	5.4	5.4	-1023	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	17676.0	7074	None	25	Human	Functional	pAC50	=	5.4	5.4	-1023	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7074	None	25	Human	Functional	pAC50	=	5.4	5.4	-1023	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7074	None	25	Human	Functional	pAC50	=	5.4	5.4	-1023	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	DB01063	7074	None	25	Human	Functional	pAC50	=	5.4	5.4	-1023	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	16362	3125	None	49	Human	Functional	pAC50	=	4.4	4.4	-371	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16362.0	3125	None	49	Human	Functional	pAC50	=	4.4	4.4	-371	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3125	None	49	Human	Functional	pAC50	=	4.4	4.4	-371	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3125	None	49	Human	Functional	pAC50	=	4.4	4.4	-371	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3125	None	49	Human	Functional	pAC50	=	4.4	4.4	-371	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3125	None	49	Human	Functional	pAC50	=	4.4	4.4	-371	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	11561674	189720	None	60	Human	Functional	pAC50	=	5.4	5.4	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	460	8	1	7	2.4	CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL514800	189720	None	60	Human	Functional	pAC50	=	5.4	5.4	-	1	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	460	8	1	7	2.4	CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC	10.1038/s41467-023-40064-9
	135398737	958	None	57	Human	Functional	pAC50	=	7.3	7.3	-8	43	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	135398737.0	958	None	57	Human	Functional	pAC50	=	7.3	7.3	-8	43	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	958	None	57	Human	Functional	pAC50	=	7.3	7.3	-8	43	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	958	None	57	Human	Functional	pAC50	=	7.3	7.3	-8	43	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	958	None	57	Human	Functional	pAC50	=	7.3	7.3	-8	43	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	958	None	57	Human	Functional	pAC50	=	7.3	7.3	-8	43	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1222	1664	None	37	Human	Functional	pAC50	=	5.3	5.3	-107	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1664	None	37	Human	Functional	pAC50	=	5.3	5.3	-107	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396.0	1664	None	37	Human	Functional	pAC50	=	5.3	5.3	-107	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1664	None	37	Human	Functional	pAC50	=	5.3	5.3	-107	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1664	None	37	Human	Functional	pAC50	=	5.3	5.3	-107	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1664	None	37	Human	Functional	pAC50	=	5.3	5.3	-107	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	228	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-575	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-575	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-575	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005.0	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-575	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-575	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	445	None	20	Human	Functional	pAC50	=	5.3	5.3	-575	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	19675	51685	None	37	Human	Functional	pAC50	=	5.3	5.3	-363	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51685	None	37	Human	Functional	pAC50	=	5.3	5.3	-363	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	49806720	60100	None	66	Human	Functional	pAC50	=	6.3	6.3	1	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1738797	60100	None	66	Human	Functional	pAC50	=	6.3	6.3	1	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	212	3806	None	35	Human	Functional	pAC50	=	5.3	5.3	-758	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3806	None	35	Human	Functional	pAC50	=	5.3	5.3	-758	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3806	None	35	Human	Functional	pAC50	=	5.3	5.3	-758	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651.0	3806	None	35	Human	Functional	pAC50	=	5.3	5.3	-758	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3806	None	35	Human	Functional	pAC50	=	5.3	5.3	-758	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3806	None	35	Human	Functional	pAC50	=	5.3	5.3	-758	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2318	154946	None	18	Human	Functional	pAC50	=	6.3	6.3	3	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154946	None	18	Human	Functional	pAC50	=	6.3	6.3	3	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	1427	2013	None	42	Human	Functional	pAC50	=	5.3	5.3	-1621	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2013	None	42	Human	Functional	pAC50	=	5.3	5.3	-1621	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2013	None	42	Human	Functional	pAC50	=	5.3	5.3	-1621	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2013	None	42	Human	Functional	pAC50	=	5.3	5.3	-1621	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2013	None	42	Human	Functional	pAC50	=	5.3	5.3	-1621	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2303	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3187	None	44	Human	Functional	pAC50	=	5.3	5.3	-389	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	5329102	194838	None	50	Human	Functional	pAC50	=	5.3	5.3	-8	37	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194838	None	50	Human	Functional	pAC50	=	5.3	5.3	-8	37	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	2470	3653	None	40	Human	Functional	pAC50	=	5.3	5.3	-30902	23	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3653	None	40	Human	Functional	pAC50	=	5.3	5.3	-30902	23	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3653	None	40	Human	Functional	pAC50	=	5.3	5.3	-30902	23	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3653	None	40	Human	Functional	pAC50	=	5.3	5.3	-30902	23	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3653	None	40	Human	Functional	pAC50	=	5.3	5.3	-30902	23	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3704	78218	None	21	Human	Functional	pAC50	=	5.3	5.3	3	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	CHEMBL2105022	78218	None	21	Human	Functional	pAC50	=	5.3	5.3	3	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	2585	803	None	59	Human	Functional	pAC50	=	6.3	6.3	-64	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	2585.0	803	None	59	Human	Functional	pAC50	=	6.3	6.3	-64	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	803	None	59	Human	Functional	pAC50	=	6.3	6.3	-64	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	803	None	59	Human	Functional	pAC50	=	6.3	6.3	-64	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	803	None	59	Human	Functional	pAC50	=	6.3	6.3	-64	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	803	None	59	Human	Functional	pAC50	=	6.3	6.3	-64	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	31101	729	None	28	Human	Functional	pAC50	=	6.3	6.3	-165	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	31101.0	729	None	28	Human	Functional	pAC50	=	6.3	6.3	-165	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	729	None	28	Human	Functional	pAC50	=	6.3	6.3	-165	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	729	None	28	Human	Functional	pAC50	=	6.3	6.3	-165	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	729	None	28	Human	Functional	pAC50	=	6.3	6.3	-165	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	729	None	28	Human	Functional	pAC50	=	6.3	6.3	-165	29	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	135398745	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-4	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135398745.0	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-4	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-4	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-4	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2914	None	65	Human	Functional	pAC50	=	7.3	7.3	-4	33	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2267	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-223	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	2267.0	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-223	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-223	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-223	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-223	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	559	None	45	Human	Functional	pAC50	=	5.3	5.3	-223	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3042	1414	None	26	Human	Functional	pAC50	=	5.3	5.3	-1096	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	3042.0	1414	None	26	Human	Functional	pAC50	=	5.3	5.3	-1096	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1414	None	26	Human	Functional	pAC50	=	5.3	5.3	-1096	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1414	None	26	Human	Functional	pAC50	=	5.3	5.3	-1096	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1414	None	26	Human	Functional	pAC50	=	5.3	5.3	-1096	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1414	None	26	Human	Functional	pAC50	=	5.3	5.3	-1096	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	4199	98899	None	29	Human	Functional	pAC50	=	5.3	5.3	-9	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL278819	98899	None	29	Human	Functional	pAC50	=	5.3	5.3	-9	3	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	2398	954	None	43	Human	Functional	pAC50	=	5.3	5.3	-831	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	954	None	43	Human	Functional	pAC50	=	5.3	5.3	-831	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801.0	954	None	43	Human	Functional	pAC50	=	5.3	5.3	-831	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	954	None	43	Human	Functional	pAC50	=	5.3	5.3	-831	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	954	None	43	Human	Functional	pAC50	=	5.3	5.3	-831	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	954	None	43	Human	Functional	pAC50	=	5.3	5.3	-831	36	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2284	3182	None	26	Human	Functional	pAC50	=	5.2	5.2	-89	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3182	None	26	Human	Functional	pAC50	=	5.2	5.2	-89	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3182	None	26	Human	Functional	pAC50	=	5.2	5.2	-89	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3182	None	26	Human	Functional	pAC50	=	5.2	5.2	-89	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3182	None	26	Human	Functional	pAC50	=	5.2	5.2	-89	34	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	5803	162321	None	58	Human	Functional	pAC50	=	5.2	5.2	-1	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162321	None	58	Human	Functional	pAC50	=	5.2	5.2	-1	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	1170	1633	None	50	Human	Functional	pAC50	=	5.2	5.2	-109	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	3348	1633	None	50	Human	Functional	pAC50	=	5.2	5.2	-109	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	3348.0	1633	None	50	Human	Functional	pAC50	=	5.2	5.2	-109	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	4819	1633	None	50	Human	Functional	pAC50	=	5.2	5.2	-109	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	74685737	1633	None	50	Human	Functional	pAC50	=	5.2	5.2	-109	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL914	1633	None	50	Human	Functional	pAC50	=	5.2	5.2	-109	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	DB00950	1633	None	50	Human	Functional	pAC50	=	5.2	5.2	-109	5	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	2601	3780	None	25	Human	Functional	pAC50	=	6.2	6.2	-186	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3780	None	25	Human	Functional	pAC50	=	6.2	6.2	-186	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3780	None	25	Human	Functional	pAC50	=	6.2	6.2	-186	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3780	None	25	Human	Functional	pAC50	=	6.2	6.2	-186	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3780	None	25	Human	Functional	pAC50	=	6.2	6.2	-186	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	25102847	78250	None	62	Human	Functional	pAC50	=	5.2	5.2	-4	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78250	None	62	Human	Functional	pAC50	=	5.2	5.2	-4	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	3949	100668	None	35	Human	Functional	pAC50	=	5.2	5.2	-6	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100668	None	35	Human	Functional	pAC50	=	5.2	5.2	-6	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	2435	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-20	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-20	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-20	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-20	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3590	None	59	Human	Functional	pAC50	=	6.2	6.2	-20	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	2136	3095	None	24	Human	Functional	pAC50	=	5.2	5.2	-120	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3095	None	24	Human	Functional	pAC50	=	5.2	5.2	-120	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768.0	3095	None	24	Human	Functional	pAC50	=	5.2	5.2	-120	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3095	None	24	Human	Functional	pAC50	=	5.2	5.2	-120	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3095	None	24	Human	Functional	pAC50	=	5.2	5.2	-120	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3095	None	24	Human	Functional	pAC50	=	5.2	5.2	-120	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	2367	964	None	47	Human	Functional	pAC50	=	5.2	5.2	-6	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	6167	964	None	47	Human	Functional	pAC50	=	5.2	5.2	-6	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	726	964	None	47	Human	Functional	pAC50	=	5.2	5.2	-6	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	CHEMBL107	964	None	47	Human	Functional	pAC50	=	5.2	5.2	-6	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	DB01394	964	None	47	Human	Functional	pAC50	=	5.2	5.2	-6	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	2247	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	505	None	55	Human	Functional	pAC50	=	6.2	6.2	-6	42	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	3157	1470	None	44	Human	Functional	pAC50	=	5.2	5.2	-1318	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	3157.0	1470	None	44	Human	Functional	pAC50	=	5.2	5.2	-1318	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1470	None	44	Human	Functional	pAC50	=	5.2	5.2	-1318	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1470	None	44	Human	Functional	pAC50	=	5.2	5.2	-1318	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1470	None	44	Human	Functional	pAC50	=	5.2	5.2	-1318	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1470	None	44	Human	Functional	pAC50	=	5.2	5.2	-1318	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL4743867	216518	None	10	Human	Functional	pAC50	=	7.2	7.2	-20	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	3062316	33583	None	70	Human	Functional	pAC50	=	5.2	5.2	-1	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33583	None	70	Human	Functional	pAC50	=	5.2	5.2	-1	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL5416410	33583	None	70	Human	Functional	pAC50	=	5.2	5.2	-1	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	2583	3776	None	69	Human	Functional	pAC50	=	5.2	5.2	-3548	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3776	None	69	Human	Functional	pAC50	=	5.2	5.2	-3548	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3776	None	69	Human	Functional	pAC50	=	5.2	5.2	-3548	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999.0	3776	None	69	Human	Functional	pAC50	=	5.2	5.2	-3548	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3776	None	69	Human	Functional	pAC50	=	5.2	5.2	-3548	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3776	None	69	Human	Functional	pAC50	=	5.2	5.2	-3548	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	4153	None	44	Human	Functional	pAC50	=	7.2	7.2	-6	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4153	None	44	Human	Functional	pAC50	=	7.2	7.2	-6	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4153	None	44	Human	Functional	pAC50	=	7.2	7.2	-6	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4153	None	44	Human	Functional	pAC50	=	7.2	7.2	-6	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4153	None	44	Human	Functional	pAC50	=	7.2	7.2	-6	22	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	129211	3749	None	48	Human	Functional	pAC50	=	5.2	5.2	-14125	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	129211.0	3749	None	48	Human	Functional	pAC50	=	5.2	5.2	-14125	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3749	None	48	Human	Functional	pAC50	=	5.2	5.2	-14125	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3749	None	48	Human	Functional	pAC50	=	5.2	5.2	-14125	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3749	None	48	Human	Functional	pAC50	=	5.2	5.2	-14125	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3749	None	48	Human	Functional	pAC50	=	5.2	5.2	-14125	14	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	16363	596	None	33	Human	Functional	pAC50	=	5.2	5.2	-1258	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	16363.0	596	None	33	Human	Functional	pAC50	=	5.2	5.2	-1258	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	596	None	33	Human	Functional	pAC50	=	5.2	5.2	-1258	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	596	None	33	Human	Functional	pAC50	=	5.2	5.2	-1258	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	596	None	33	Human	Functional	pAC50	=	5.2	5.2	-1258	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	596	None	33	Human	Functional	pAC50	=	5.2	5.2	-1258	21	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	92727	207010	None	50	Human	Functional	pAC50	=	5.2	5.2	-1	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	628	15	4	5	4.3	Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL729	207010	None	50	Human	Functional	pAC50	=	5.2	5.2	-1	6	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	628	15	4	5	4.3	Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O	10.1038/s41467-023-40064-9
	11504295	2923	None	40	Human	Functional	pAC50	=	5.2	5.2	-50118	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	11504295.0	2923	None	40	Human	Functional	pAC50	=	5.2	5.2	-50118	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2923	None	40	Human	Functional	pAC50	=	5.2	5.2	-50118	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2923	None	40	Human	Functional	pAC50	=	5.2	5.2	-50118	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2923	None	40	Human	Functional	pAC50	=	5.2	5.2	-50118	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2923	None	40	Human	Functional	pAC50	=	5.2	5.2	-50118	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2782	32008	None	48	Human	Functional	pAC50	=	6.2	6.2	-199	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL1407943	32008	None	48	Human	Functional	pAC50	=	6.2	6.2	-199	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL3216363	32008	None	48	Human	Functional	pAC50	=	6.2	6.2	-199	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	1353	1911	None	63	Human	Functional	pAC50	=	5.2	5.2	-851	39	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1911	None	63	Human	Functional	pAC50	=	5.2	5.2	-851	39	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559.0	1911	None	63	Human	Functional	pAC50	=	5.2	5.2	-851	39	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1911	None	63	Human	Functional	pAC50	=	5.2	5.2	-851	39	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1911	None	63	Human	Functional	pAC50	=	5.2	5.2	-851	39	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1911	None	63	Human	Functional	pAC50	=	5.2	5.2	-851	39	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2771	197264	None	50	Human	Functional	pAC50	=	6.2	6.2	-5	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	197264	None	50	Human	Functional	pAC50	=	6.2	6.2	-5	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	197264	None	50	Human	Functional	pAC50	=	6.2	6.2	-5	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1816	2540	None	64	Human	Functional	pAC50	=	5.2	5.2	-1047	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2540	None	64	Human	Functional	pAC50	=	5.2	5.2	-1047	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205.0	2540	None	64	Human	Functional	pAC50	=	5.2	5.2	-1047	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2540	None	64	Human	Functional	pAC50	=	5.2	5.2	-1047	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2540	None	64	Human	Functional	pAC50	=	5.2	5.2	-1047	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2540	None	64	Human	Functional	pAC50	=	5.2	5.2	-1047	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4485	69401	None	70	Human	Functional	pAC50	=	5.2	5.2	-42	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL193	69401	None	70	Human	Functional	pAC50	=	5.2	5.2	-42	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	4567	9950	None	29	Human	Functional	pAC50	=	5.2	5.2	-41	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9950	None	29	Human	Functional	pAC50	=	5.2	5.2	-41	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	179	400	None	72	Human	Functional	pAC50	=	6.2	6.2	-102	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	2159	400	None	72	Human	Functional	pAC50	=	6.2	6.2	-102	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	2159.0	400	None	72	Human	Functional	pAC50	=	6.2	6.2	-102	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	963	400	None	72	Human	Functional	pAC50	=	6.2	6.2	-102	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	CHEMBL243712	400	None	72	Human	Functional	pAC50	=	6.2	6.2	-102	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	DB06288	400	None	72	Human	Functional	pAC50	=	6.2	6.2	-102	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	213046	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-4	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	213046.0	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-4	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-4	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-4	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-4	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2385	None	44	Human	Functional	pAC50	=	7.2	7.2	-4	17	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	1971	2866	None	32	Human	Functional	pAC50	=	6.1	6.1	-165	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2866	None	32	Human	Functional	pAC50	=	6.1	6.1	-165	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2866	None	32	Human	Functional	pAC50	=	6.1	6.1	-165	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543.0	2866	None	32	Human	Functional	pAC50	=	6.1	6.1	-165	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2866	None	32	Human	Functional	pAC50	=	6.1	6.1	-165	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2866	None	32	Human	Functional	pAC50	=	6.1	6.1	-165	32	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2448	99377	None	50	Human	Functional	pAC50	=	5.1	5.1	-331	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	2448.0	99377	None	50	Human	Functional	pAC50	=	5.1	5.1	-331	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99377	None	50	Human	Functional	pAC50	=	5.1	5.1	-331	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	DB12401	99377	None	50	Human	Functional	pAC50	=	5.1	5.1	-331	15	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	1830	2590	None	33	Human	Functional	pAC50	=	6.1	6.1	-8	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2590	None	33	Human	Functional	pAC50	=	6.1	6.1	-8	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2590	None	33	Human	Functional	pAC50	=	6.1	6.1	-8	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897.0	2590	None	33	Human	Functional	pAC50	=	6.1	6.1	-8	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2590	None	33	Human	Functional	pAC50	=	6.1	6.1	-8	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2590	None	33	Human	Functional	pAC50	=	6.1	6.1	-8	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	2477	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-104	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	2477.0	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-104	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	36	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-104	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	437	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-104	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL49	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-104	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	DB00490	745	None	38	Human	Functional	pAC50	=	5.1	5.1	-104	20	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	5906	14501	None	15	Human	Functional	pAC50	=	5.1	5.1	1	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	5906.0	14501	None	15	Human	Functional	pAC50	=	5.1	5.1	1	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14501	None	15	Human	Functional	pAC50	=	5.1	5.1	1	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	DB00610	14501	None	15	Human	Functional	pAC50	=	5.1	5.1	1	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	54682461	84720	None	41	Human	Functional	pAC50	=	5.1	5.1	-1	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84720	None	41	Human	Functional	pAC50	=	5.1	5.1	-1	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	68617	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-14	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-14	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	207985	None	33	Human	Functional	pAC50	=	5.1	5.1	-14	30	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	20628	96601	None	25	Human	Functional	pAC50	=	6.1	6.1	1	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96601	None	25	Human	Functional	pAC50	=	6.1	6.1	1	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	209	3057	None	57	Human	Functional	pAC50	=	6.1	6.1	-338	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2113	3057	None	57	Human	Functional	pAC50	=	6.1	6.1	-338	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748	3057	None	57	Human	Functional	pAC50	=	6.1	6.1	-338	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748.0	3057	None	57	Human	Functional	pAC50	=	6.1	6.1	-338	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL567	3057	None	57	Human	Functional	pAC50	=	6.1	6.1	-338	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00850	3057	None	57	Human	Functional	pAC50	=	6.1	6.1	-338	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2540	4402	None	68	Human	Functional	pAC50	=	5.1	5.1	-1122	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4402	None	68	Human	Functional	pAC50	=	5.1	5.1	-1122	28	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	1212	1662	None	37	Human	Functional	pAC50	=	6.1	6.1	-60	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1662	None	37	Human	Functional	pAC50	=	6.1	6.1	-60	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1662	None	37	Human	Functional	pAC50	=	6.1	6.1	-60	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372.0	1662	None	37	Human	Functional	pAC50	=	6.1	6.1	-60	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1662	None	37	Human	Functional	pAC50	=	6.1	6.1	-60	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1662	None	37	Human	Functional	pAC50	=	6.1	6.1	-60	35	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	71496458	115628	None	61	Human	Functional	pAC50	=	6.1	6.1	-2	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115628	None	61	Human	Functional	pAC50	=	6.1	6.1	-2	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	4418	34231	None	58	Human	Functional	pAC50	=	6.1	6.1	-3	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	4418.0	34231	None	58	Human	Functional	pAC50	=	6.1	6.1	-3	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34231	None	58	Human	Functional	pAC50	=	6.1	6.1	-3	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	DB12092	34231	None	58	Human	Functional	pAC50	=	6.1	6.1	-3	18	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	2880	98061	None	34	Human	Functional	pAC50	=	5.1	5.1	-8	9	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL27289	98061	None	34	Human	Functional	pAC50	=	5.1	5.1	-8	9	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	4178	198259	None	39	Human	Functional	pAC50	=	5.1	5.1	3	2	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	CHEMBL558	198259	None	39	Human	Functional	pAC50	=	5.1	5.1	3	2	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	1234	189330	None	32	Human	Functional	pAC50	=	6.1	6.1	9	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189330	None	32	Human	Functional	pAC50	=	6.1	6.1	9	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189330	None	32	Human	Functional	pAC50	=	6.1	6.1	9	10	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	6018	11069	None	60	Human	Functional	pAC50	=	5.1	5.1	2	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	CHEMBL117785	11069	None	60	Human	Functional	pAC50	=	5.1	5.1	2	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	118422671	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	189562.0	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301.0	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	9844194.0	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL2365658	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL3526436	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2757	None	41	Human	Functional	pAC50	=	5.1	5.1	-2884	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	11980903	14498	None	13	Human	Functional	pAC50	=	5.1	5.1	-239	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14498	None	13	Human	Functional	pAC50	=	5.1	5.1	-239	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14498	None	13	Human	Functional	pAC50	=	5.1	5.1	-239	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14498	None	13	Human	Functional	pAC50	=	5.1	5.1	-239	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	138106885	167007	None	49	Human	Functional	pAC50	=	5.1	5.1	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	36314	167007	None	49	Human	Functional	pAC50	=	5.1	5.1	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	CHEMBL428647	167007	None	49	Human	Functional	pAC50	=	5.1	5.1	-4	8	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	5282175	14437	None	23	Human	Functional	pAC50	=	6.1	6.1	6	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1200661	14437	None	23	Human	Functional	pAC50	=	6.1	6.1	6	4	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	1530	2182	None	36	Human	Functional	pAC50	=	7.1	7.1	-3	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2182	None	36	Human	Functional	pAC50	=	7.1	7.1	-3	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827.0	2182	None	36	Human	Functional	pAC50	=	7.1	7.1	-3	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2182	None	36	Human	Functional	pAC50	=	7.1	7.1	-3	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2182	None	36	Human	Functional	pAC50	=	7.1	7.1	-3	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2182	None	36	Human	Functional	pAC50	=	7.1	7.1	-3	25	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	5311507	194927	None	32	Human	Functional	pAC50	=	6.0	6.0	-10	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	5311507.0	194927	None	32	Human	Functional	pAC50	=	6.0	6.0	-10	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194927	None	32	Human	Functional	pAC50	=	6.0	6.0	-10	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	DB01624	194927	None	32	Human	Functional	pAC50	=	6.0	6.0	-10	12	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	216416	111644	None	40	Human	Functional	pAC50	=	5.0	5.0	-19	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111644	None	40	Human	Functional	pAC50	=	5.0	5.0	-19	23	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	65700	78289	None	22	Human	Functional	pAC50	=	6.0	6.0	-2	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78289	None	22	Human	Functional	pAC50	=	6.0	6.0	-2	8	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	2291	3184	None	43	Human	Functional	pAC50	=	5.0	5.0	-17	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2561	3184	None	43	Human	Functional	pAC50	=	5.0	5.0	-17	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932	3184	None	43	Human	Functional	pAC50	=	5.0	5.0	-17	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932.0	3184	None	43	Human	Functional	pAC50	=	5.0	5.0	-17	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL631	3184	None	43	Human	Functional	pAC50	=	5.0	5.0	-17	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB01182	3184	None	43	Human	Functional	pAC50	=	5.0	5.0	-17	13	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	5472	208276	None	49	Human	Functional	pAC50	=	5.0	5.0	-16	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	5472.0	208276	None	49	Human	Functional	pAC50	=	5.0	5.0	-16	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	208276	None	49	Human	Functional	pAC50	=	5.0	5.0	-16	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	208276	None	49	Human	Functional	pAC50	=	5.0	5.0	-16	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	DB00208	208276	None	49	Human	Functional	pAC50	=	5.0	5.0	-16	16	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2780	110592	None	24	Human	Functional	pAC50	=	6.0	6.0	-9	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	2780.0	110592	None	24	Human	Functional	pAC50	=	6.0	6.0	-9	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110592	None	24	Human	Functional	pAC50	=	6.0	6.0	-9	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	DB13511	110592	None	24	Human	Functional	pAC50	=	6.0	6.0	-9	11	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	43815	187026	None	38	Human	Functional	pAC50	=	5	5.0	-125	20	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	187026	None	38	Human	Functional	pAC50	=	5	5.0	-125	20	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	187026	None	38	Human	Functional	pAC50	=	5	5.0	-125	20	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	5	139	None	45	Human	Functional	pEC50	=	10.2	10.2	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5202	139	None	45	Human	Functional	pEC50	=	10.2	10.2	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	10.2	10.2	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	DB08839	139	None	45	Human	Functional	pEC50	=	10.2	10.2	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	None	45	Human	Functional	pEC50	=	9.4	9.4	-2	26	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5202	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	DB08839	139	None	45	Human	Functional	pEC50	=	9.3	9.3	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	4376990	193118	None	4	Human	Functional	pEC50	=	9.2	9.2	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193118	None	4	Human	Functional	pEC50	=	9.2	9.2	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193118	None	4	Human	Functional	pEC50	=	9.2	9.2	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4376990	193118	None	4	Human	Functional	pEC50	=	9.2	9.2	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	193118	None	4	Human	Functional	pEC50	=	9.2	9.2	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	193118	None	4	Human	Functional	pEC50	=	9.2	9.2	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	5	139	None	45	Human	Functional	pEC50	=	9.1	9.1	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5202	139	None	45	Human	Functional	pEC50	=	9.1	9.1	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.1	9.1	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	DB08839	139	None	45	Human	Functional	pEC50	=	9.1	9.1	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	5202	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	DB08839	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	439280	120083	None	57	Human	Functional	pEC50	=	9	9.0	-25	9	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120083	None	57	Human	Functional	pEC50	=	9	9.0	-25	9	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120083	None	57	Human	Functional	pEC50	=	9	9.0	-25	9	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	5	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	None	45	Human	Functional	pEC50	=	9.0	9.0	-2	26	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	5202	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	DB08839	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	5	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	5202	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	DB08839	139	None	45	Human	Functional	pEC50	=	8.9	8.9	-2	26	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.3c00454
	439280	120083	None	57	Human	Functional	pEC50	=	8.9	8.9	-25	9	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	120083	None	57	Human	Functional	pEC50	=	8.9	8.9	-25	9	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	120083	None	57	Human	Functional	pEC50	=	8.9	8.9	-25	9	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	168293874	192288	None	0	Human	Functional	pEC50	=	8.9	8.9	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192288	None	0	Human	Functional	pEC50	=	8.9	8.9	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168293874	192288	None	0	Human	Functional	pEC50	=	8.9	8.9	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192288	None	0	Human	Functional	pEC50	=	8.9	8.9	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	5	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	None	45	Human	Functional	pEC50	=	8.8	8.8	-2	26	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	166	3359	None	19	Human	Functional	pEC50	=	8.8	8.8	2	5	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	3045227	3359	None	19	Human	Functional	pEC50	=	8.8	8.8	2	5	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	8.8	8.8	2	5	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	172469352	197023	None	0	Human	Functional	pEC50	=	8	8.0	57	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	214	1	3	3	1.5	Nc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5437030	197023	None	0	Human	Functional	pEC50	=	8	8.0	57	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	214	1	3	3	1.5	Nc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	4407909	192975	None	0	Human	Functional	pEC50	=	8	8.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192975	None	0	Human	Functional	pEC50	=	8	8.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192975	None	0	Human	Functional	pEC50	=	8	8.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44315993	172980	None	0	Human	Functional	pEC50	=	8	8.0	2	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172980	None	0	Human	Functional	pEC50	=	8	8.0	2	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	168941715	196900	None	0	Human	Functional	pEC50	=	8.0	8.0	8	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5434434	196900	None	0	Human	Functional	pEC50	=	8.0	8.0	8	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	4407909	192975	None	0	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192975	None	0	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192975	None	0	Human	Functional	pEC50	=	8.0	8.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	16115269	138216	None	0	Human	Functional	pEC50	=	7	7.0	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	138216	None	0	Human	Functional	pEC50	=	7	7.0	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9881885	64130	None	0	Human	Functional	pEC50	=	7	7.0	-19	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180815	64130	None	0	Human	Functional	pEC50	=	7	7.0	-19	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63959	None	17	Human	Functional	pEC50	=	6	6.0	-81	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL180668	63959	None	17	Human	Functional	pEC50	=	6	6.0	-81	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	10465263	64353	None	37	Human	Functional	pEC50	=	6	6.0	-89	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL181172	64353	None	37	Human	Functional	pEC50	=	6	6.0	-89	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11938	2412	None	8	Human	Functional	pEC50	=	6	6.0	-75	4	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2412	None	8	Human	Functional	pEC50	=	6	6.0	-75	4	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2412	None	8	Human	Functional	pEC50	=	6	6.0	-75	4	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	59312249	111735	None	0	Human	Functional	pEC50	=	6	6.0	-8	2	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286565	111735	None	0	Human	Functional	pEC50	=	6	6.0	-8	2	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	122442324	138437	None	0	Human	Functional	pEC50	=	6	6.0	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138437	None	0	Human	Functional	pEC50	=	6	6.0	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138437	None	0	Human	Functional	pEC50	=	6	6.0	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11658860	2344	None	24	Human	Functional	pEC50	=	6	6.0	-35	11	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	2941	2344	None	24	Human	Functional	pEC50	=	6	6.0	-35	11	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	4374	2344	None	24	Human	Functional	pEC50	=	6	6.0	-35	11	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6	6.0	-35	11	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	DB04871	2344	None	24	Human	Functional	pEC50	=	6	6.0	-35	11	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	10379910	63321	None	0	Human	Functional	pEC50	=	6	6.0	-6	2	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179329	63321	None	0	Human	Functional	pEC50	=	6	6.0	-6	2	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63959	None	17	Human	Functional	pEC50	=	6	6.0	-81	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180668	63959	None	17	Human	Functional	pEC50	=	6	6.0	-81	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL4913232	216564	None	7	Human	Functional	pEC50	=	6	6.0	-6	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL		None	None	None		C1=CC2(CCNCC2)Oc2ccccc21	10.1021/acsmedchemlett.3c00454
	122442324	138437	None	0	Human	Functional	pEC50	=	6	6.0	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138437	None	0	Human	Functional	pEC50	=	6	6.0	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138437	None	0	Human	Functional	pEC50	=	6	6.0	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11493484	89104	None	0	Human	Functional	pEC50	=	7	7.0	-23	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	89104	None	0	Human	Functional	pEC50	=	7	7.0	-23	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	89104	None	0	Human	Functional	pEC50	=	7	7.0	-23	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	46230097	201822	None	0	Human	Functional	pEC50	=	7	7.0	-6	3	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	201822	None	0	Human	Functional	pEC50	=	7	7.0	-6	3	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	122442251	138447	None	0	Human	Functional	pEC50	=	7	7.0	-15	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138447	None	0	Human	Functional	pEC50	=	7	7.0	-15	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138447	None	0	Human	Functional	pEC50	=	7	7.0	-15	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	4312735	192983	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192983	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192983	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4312735	192983	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192983	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192983	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	122442251	138447	None	0	Human	Functional	pEC50	=	7.0	7.0	-15	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138447	None	0	Human	Functional	pEC50	=	7.0	7.0	-15	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138447	None	0	Human	Functional	pEC50	=	7.0	7.0	-15	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573155	189268	None	0	Human	Functional	pEC50	=	7.0	7.0	6	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL511044	189268	None	0	Human	Functional	pEC50	=	7.0	7.0	6	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	168282202	192993	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192993	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192993	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168282202	192993	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192993	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192993	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	44412404	77797	None	4	Human	Functional	pEC50	=	7.0	7.0	2	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209106	77797	None	4	Human	Functional	pEC50	=	7.0	7.0	2	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	70693928	74511	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2022192	74511	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2028036	74511	None	0	Human	Functional	pEC50	=	6.0	6.0	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	162652937	183768	None	0	Human	Functional	pEC50	=	7.0	7.0	-67	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183768	None	0	Human	Functional	pEC50	=	7.0	7.0	-67	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183768	None	0	Human	Functional	pEC50	=	7.0	7.0	-67	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168941715	196900	None	0	Human	Functional	pEC50	=	8.0	8.0	8	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5434434	196900	None	0	Human	Functional	pEC50	=	8.0	8.0	8	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	229	2	2	3	1.9	COc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	5	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-2	26	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	5202	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-2	26	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-2	26	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	DB08839	139	None	45	Human	Functional	pEC50	=	8.0	8.0	-2	26	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	168	3982	None	15	Human	Functional	pEC50	=	8.0	8.0	3	5	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3982	None	15	Human	Functional	pEC50	=	8.0	8.0	3	5	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3982	None	15	Human	Functional	pEC50	=	8.0	8.0	3	5	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	157	2069	None	2	Rat	Functional	pEC50	=	7.9	7.9	2	3	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	9840090	2069	None	2	Rat	Functional	pEC50	=	7.9	7.9	2	3	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	CHEMBL134519	2069	None	2	Rat	Functional	pEC50	=	7.9	7.9	2	3	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	157	2069	None	2	Rat	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	9840090	2069	None	2	Rat	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	CHEMBL134519	2069	None	2	Rat	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	10465263	64353	None	37	Human	Functional	pEC50	=	6.0	6.0	-89	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181172	64353	None	37	Human	Functional	pEC50	=	6.0	6.0	-89	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	162652937	183768	None	0	Human	Functional	pEC50	=	7.0	7.0	-67	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183768	None	0	Human	Functional	pEC50	=	7.0	7.0	-67	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183768	None	0	Human	Functional	pEC50	=	7.0	7.0	-67	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265627	164108	None	0	Human	Functional	pEC50	=	6.9	6.9	-602	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	CHEMBL4208452	164108	None	0	Human	Functional	pEC50	=	6.9	6.9	-602	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	53324327	56866	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643857	56866	None	0	Human	Functional	pEC50	=	5.9	5.9	-1	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	44572176	12564	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL1186735	12564	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL475641	12564	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	44572207	12706	None	0	Human	Functional	pEC50	=	6.9	6.9	-8	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL1187556	12706	None	0	Human	Functional	pEC50	=	6.9	6.9	-8	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL508680	12706	None	0	Human	Functional	pEC50	=	6.9	6.9	-8	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	11492162	72077	None	1	Human	Functional	pEC50	=	5.9	5.9	-11	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197646	72077	None	1	Human	Functional	pEC50	=	5.9	5.9	-11	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	53317924	56867	None	0	Human	Functional	pEC50	=	5.9	5.9	-6	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643858	56867	None	0	Human	Functional	pEC50	=	5.9	5.9	-6	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	44572180	12566	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL1186737	12566	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL475643	12566	None	0	Human	Functional	pEC50	=	7.9	7.9	2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	11151653	91135	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	91135	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	54587668	61479	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770378	61479	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	1355	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	142	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	DB12110	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	44573156	187403	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492949	187403	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1355	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	142	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	DB12110	2011	None	45	Human	Functional	pEC50	=	6.9	6.9	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	168285159	193023	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	193023	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	193023	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	23652278	62651	None	11	Human	Functional	pEC50	=	5.9	5.9	-83	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL178365	62651	None	11	Human	Functional	pEC50	=	5.9	5.9	-83	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11608308	64330	None	3	Human	Functional	pEC50	=	5.9	5.9	-407	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL181076	64330	None	3	Human	Functional	pEC50	=	5.9	5.9	-407	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	162658803	183798	None	0	Human	Functional	pEC50	=	6.9	6.9	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183798	None	0	Human	Functional	pEC50	=	6.9	6.9	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183798	None	0	Human	Functional	pEC50	=	6.9	6.9	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168285159	193023	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	193023	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	193023	None	0	Human	Functional	pEC50	=	6.9	6.9	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162658803	183798	None	0	Human	Functional	pEC50	=	6.9	6.9	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183798	None	0	Human	Functional	pEC50	=	6.9	6.9	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183798	None	0	Human	Functional	pEC50	=	6.9	6.9	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265732	163902	None	0	Human	Functional	pEC50	=	5.9	5.9	-1000	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4206126	163902	None	0	Human	Functional	pEC50	=	5.9	5.9	-1000	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	134265665	164894	None	0	Human	Functional	pEC50	=	5.9	5.9	-1047	2	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4218374	164894	None	0	Human	Functional	pEC50	=	5.9	5.9	-1047	2	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44572751	12503	None	0	Human	Functional	pEC50	=	7.9	7.9	-16	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12503	None	0	Human	Functional	pEC50	=	7.9	7.9	-16	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12503	None	0	Human	Functional	pEC50	=	7.9	7.9	-16	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	53321948	56820	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643677	56820	None	0	Human	Functional	pEC50	=	7.9	7.9	1	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	189	3492	None	32	Human	Functional	pEC50	=	7.9	7.9	-1	4	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	5163	3492	None	32	Human	Functional	pEC50	=	7.9	7.9	-1	4	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	CHEMBL297784	3492	None	32	Human	Functional	pEC50	=	7.9	7.9	-1	4	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	44431699	88323	None	0	Rat	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234837	88323	None	0	Rat	Functional	pEC50	=	6.9	6.9	5	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	10015414	63505	None	0	Human	Functional	pEC50	=	6.9	6.9	-32	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179915	63505	None	0	Human	Functional	pEC50	=	6.9	6.9	-32	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	16115271	79139	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	79139	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	170453288	196449	None	2	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5424175	196449	None	2	Human	Functional	pEC50	=	7.9	7.9	6	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	44572168	12488	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL1186458	12488	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL464475	12488	None	0	Human	Functional	pEC50	=	7.9	7.9	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	10036629	64658	None	0	Human	Functional	pEC50	=	6.9	6.9	-9	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL181787	64658	None	0	Human	Functional	pEC50	=	6.9	6.9	-9	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	23652278	62651	None	11	Human	Functional	pEC50	=	5.9	5.9	-83	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178365	62651	None	11	Human	Functional	pEC50	=	5.9	5.9	-83	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	25084025	12705	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL1187522	12705	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL506727	12705	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	45484687	200920	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577410	200920	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	53323196	56865	None	0	Human	Functional	pEC50	=	5.8	5.8	-23	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643856	56865	None	0	Human	Functional	pEC50	=	5.8	5.8	-23	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	118736623	119060	None	6	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425755	119060	None	6	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118733808	120720	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416056	120720	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546908	120720	None	0	Human	Functional	pEC50	=	5.8	5.8	-1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	44573231	187400	None	0	Human	Functional	pEC50	=	7.8	7.8	5	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492911	187400	None	0	Human	Functional	pEC50	=	7.8	7.8	5	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	216	2860	None	26	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	9815618	2860	None	26	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	CHEMBL253811	2860	None	26	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	162653458	183772	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183772	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183772	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	10331841	169307	None	5	Human	Functional	pEC50	=	5.8	5.8	-158	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL440752	169307	None	5	Human	Functional	pEC50	=	5.8	5.8	-158	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	44412389	78125	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210215	78125	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	162653458	183772	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183772	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183772	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11447552	62548	None	2	Human	Functional	pEC50	=	5.8	5.8	-239	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178231	62548	None	2	Human	Functional	pEC50	=	5.8	5.8	-239	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	168941654	195567	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	CHEMBL5406172	195567	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	168941654	195567	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	CHEMBL5406172	195567	None	0	Human	Functional	pEC50	=	7.8	7.8	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	199	1	2	2	1.9	C1=C(c2n[nH]c3ccccc23)CNCC1	10.1021/acsmedchemlett.3c00566
	54585653	61485	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770385	61485	None	0	Human	Functional	pEC50	=	6.8	6.8	1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11427139	84721	None	0	Human	Functional	pEC50	=	5.8	5.8	-38	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84721	None	0	Human	Functional	pEC50	=	5.8	5.8	-38	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53325937	56821	None	0	Human	Functional	pEC50	=	6.8	6.8	-53	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643678	56821	None	0	Human	Functional	pEC50	=	6.8	6.8	-53	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	25070581	61481	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770380	61481	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	134265616	164506	None	0	Human	Functional	pEC50	=	6.8	6.8	-1548	2	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4213447	164506	None	0	Human	Functional	pEC50	=	6.8	6.8	-1548	2	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	122442286	138438	None	0	Human	Functional	pEC50	=	6.8	6.8	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	6.8	6.8	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	6.8	6.8	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733798	120713	None	0	Human	Functional	pEC50	=	5.8	5.8	-12	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416051	120713	None	0	Human	Functional	pEC50	=	5.8	5.8	-12	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546894	120713	None	0	Human	Functional	pEC50	=	5.8	5.8	-12	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44573220	187557	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493951	187557	None	0	Human	Functional	pEC50	=	7.8	7.8	4	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	162658689	183796	None	0	Human	Functional	pEC50	=	6.8	6.8	-28	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183796	None	0	Human	Functional	pEC50	=	6.8	6.8	-28	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183796	None	0	Human	Functional	pEC50	=	6.8	6.8	-28	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	138435	None	0	Human	Functional	pEC50	=	5.8	5.8	-54	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138435	None	0	Human	Functional	pEC50	=	5.8	5.8	-54	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138435	None	0	Human	Functional	pEC50	=	5.8	5.8	-54	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572371	12531	None	0	Human	Functional	pEC50	=	5.8	5.8	-5	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL1186608	12531	None	0	Human	Functional	pEC50	=	5.8	5.8	-5	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL472678	12531	None	0	Human	Functional	pEC50	=	5.8	5.8	-5	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	162658689	183796	None	0	Human	Functional	pEC50	=	6.8	6.8	-28	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183796	None	0	Human	Functional	pEC50	=	6.8	6.8	-28	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183796	None	0	Human	Functional	pEC50	=	6.8	6.8	-28	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	138435	None	0	Human	Functional	pEC50	=	5.8	5.8	-54	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138435	None	0	Human	Functional	pEC50	=	5.8	5.8	-54	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138435	None	0	Human	Functional	pEC50	=	5.8	5.8	-54	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115652	83524	None	0	Human	Functional	pEC50	=	6.8	6.8	-15	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83524	None	0	Human	Functional	pEC50	=	6.8	6.8	-15	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	54580776	61482	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770381	61482	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	118736624	119061	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425756	119061	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573229	172779	None	0	Human	Functional	pEC50	=	7.8	7.8	-2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	CHEMBL449999	172779	None	0	Human	Functional	pEC50	=	7.8	7.8	-2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	42601405	192763	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL521805	192763	None	0	Human	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	11221167	84714	None	0	Human	Functional	pEC50	=	6.8	6.8	-25	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84714	None	0	Human	Functional	pEC50	=	6.8	6.8	-25	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	162657053	183787	None	0	Human	Functional	pEC50	=	6.8	6.8	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183787	None	0	Human	Functional	pEC50	=	6.8	6.8	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183787	None	0	Human	Functional	pEC50	=	6.8	6.8	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	10401602	123135	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360968	123135	None	0	Human	Functional	pEC50	=	6.8	6.8	-6	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	11447552	62548	None	2	Human	Functional	pEC50	=	5.8	5.8	-239	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178231	62548	None	2	Human	Functional	pEC50	=	5.8	5.8	-239	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	25070907	61477	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770376	61477	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	44572369	12462	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186108	12462	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL450178	12462	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	46228438	202441	None	0	Human	Functional	pEC50	=	6.7	6.7	-1862	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595195	202441	None	0	Human	Functional	pEC50	=	6.7	6.7	-1862	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	164513426	195281	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	2	2	2.2	C[C@@H]1C=C(c2c[nH]c3ncccc23)CNC1	10.1021/acsmedchemlett.3c00566
	CHEMBL5399968	195281	None	0	Human	Functional	pEC50	=	6.7	6.7	-4	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	2	2	2.2	C[C@@H]1C=C(c2c[nH]c3ncccc23)CNC1	10.1021/acsmedchemlett.3c00566
	45485742	200279	None	0	Human	Functional	pEC50	=	6.7	6.7	-18	3	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572228	200279	None	0	Human	Functional	pEC50	=	6.7	6.7	-18	3	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	44412405	77810	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209155	77810	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	85542158	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	11777150	62625	None	0	Human	Functional	pEC50	=	6.7	6.7	-63	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178313	62625	None	0	Human	Functional	pEC50	=	6.7	6.7	-63	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	85542158	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	6.7	6.7	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	11414184	83531	None	0	Human	Functional	pEC50	=	6.7	6.7	-7	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83531	None	0	Human	Functional	pEC50	=	6.7	6.7	-7	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	122442324	138437	None	0	Human	Functional	pEC50	=	5.7	5.7	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138437	None	0	Human	Functional	pEC50	=	5.7	5.7	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138437	None	0	Human	Functional	pEC50	=	5.7	5.7	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442324	138437	None	0	Human	Functional	pEC50	=	5.7	5.7	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138437	None	0	Human	Functional	pEC50	=	5.7	5.7	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138437	None	0	Human	Functional	pEC50	=	5.7	5.7	-12	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573216	187444	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493151	187444	None	0	Human	Functional	pEC50	=	6.7	6.7	4	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572759	12466	None	0	Human	Functional	pEC50	=	6.7	6.7	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186135	12466	None	0	Human	Functional	pEC50	=	6.7	6.7	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL451368	12466	None	0	Human	Functional	pEC50	=	6.7	6.7	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	24773650	154787	None	2	Human	Functional	pEC50	=	6.7	6.7	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	CHEMBL399750	154787	None	2	Human	Functional	pEC50	=	6.7	6.7	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	118733818	120729	None	0	Human	Functional	pEC50	=	5.7	5.7	-181	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416061	120729	None	0	Human	Functional	pEC50	=	5.7	5.7	-181	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546956	120729	None	0	Human	Functional	pEC50	=	5.7	5.7	-181	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168294162	193120	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	193120	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	193120	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10331841	169307	None	5	Human	Functional	pEC50	=	5.7	5.7	-158	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	CHEMBL440752	169307	None	5	Human	Functional	pEC50	=	5.7	5.7	-158	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	168294162	193120	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	193120	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	193120	None	0	Human	Functional	pEC50	=	5.7	5.7	1	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	135453290	133675	None	29	Rat	Functional	pEC50	=	8.7	8.7	1	7	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133675	None	29	Rat	Functional	pEC50	=	8.7	8.7	1	7	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	5	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	5202	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	DB08839	139	None	45	Human	Functional	pEC50	=	8.6	8.6	-2	26	Agonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.3c00734
	166	3359	None	19	Human	Functional	pEC50	=	8.6	8.6	2	5	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	3045227	3359	None	19	Human	Functional	pEC50	=	8.6	8.6	2	5	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	8.6	8.6	2	5	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	36906	104936	None	31	Rat	Functional	pEC50	=	8.6	8.6	1	3	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	CHEMBL31115	104936	None	31	Rat	Functional	pEC50	=	8.6	8.6	1	3	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	44572367	12547	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL1186673	12547	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL474230	12547	None	0	Human	Functional	pEC50	=	6.7	6.7	1	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	168291130	193085	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	193085	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	193085	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168291130	193085	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	193085	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	193085	None	0	Human	Functional	pEC50	=	6.7	6.7	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	11290492	138088	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL376456	138088	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	11499800	89141	None	0	Human	Functional	pEC50	=	6.7	6.7	-10	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	89141	None	0	Human	Functional	pEC50	=	6.7	6.7	-10	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	89141	None	0	Human	Functional	pEC50	=	6.7	6.7	-10	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	122442254	138432	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442254	138432	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.7	6.7	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572810	12659	None	0	Human	Functional	pEC50	=	7.7	7.7	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12659	None	0	Human	Functional	pEC50	=	7.7	7.7	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12659	None	0	Human	Functional	pEC50	=	7.7	7.7	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	150	2509	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	17	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	1764	2509	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	17	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	8226	2509	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	17	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	8226.0	2509	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	17	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	CHEMBL1201356	2509	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	17	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	DB00353	2509	None	14	Human	Functional	pEC50	=	7.7	7.7	-2	17	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	134265663	163774	None	0	Human	Functional	pEC50	=	7.7	7.7	-19	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4204710	163774	None	0	Human	Functional	pEC50	=	7.7	7.7	-19	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	53317923	56862	None	0	Human	Functional	pEC50	=	6.7	6.7	-5	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643853	56862	None	0	Human	Functional	pEC50	=	6.7	6.7	-5	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	53325936	56818	None	0	Human	Functional	pEC50	=	6.7	6.7	-12	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643675	56818	None	0	Human	Functional	pEC50	=	6.7	6.7	-12	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	122442293	138429	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138429	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138429	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	122442293	138429	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138429	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138429	None	0	Human	Functional	pEC50	=	5.7	5.7	-19	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	11658860	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.7	6.7	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	16115381	83476	None	0	Human	Functional	pEC50	=	7.7	7.7	1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83476	None	0	Human	Functional	pEC50	=	7.7	7.7	1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	44572166	12464	None	0	Human	Functional	pEC50	=	7.7	7.7	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12464	None	0	Human	Functional	pEC50	=	7.7	7.7	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12464	None	0	Human	Functional	pEC50	=	7.7	7.7	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	118736626	119062	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425758	119062	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	18735305	207391	None	0	Human	Functional	pEC50	=	7.7	7.7	2	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	207391	None	0	Human	Functional	pEC50	=	7.7	7.7	2	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	54583742	61476	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770375	61476	None	0	Human	Functional	pEC50	=	6.7	6.7	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	44389645	64202	None	0	Human	Functional	pEC50	=	6.7	6.7	-72	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180867	64202	None	0	Human	Functional	pEC50	=	6.7	6.7	-72	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733790	120735	None	0	Human	Functional	pEC50	=	5.7	5.7	-36	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416047	120735	None	0	Human	Functional	pEC50	=	5.7	5.7	-36	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546973	120735	None	0	Human	Functional	pEC50	=	5.7	5.7	-36	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44572753	12707	None	2	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187565	12707	None	2	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL509418	12707	None	2	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	53321947	56814	None	0	Human	Functional	pEC50	=	5.7	5.7	-2	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643671	56814	None	0	Human	Functional	pEC50	=	5.7	5.7	-2	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	216	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of MAPK cascade by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of MAPK cascade by calcium mobilization assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	9815618	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of MAPK cascade by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of MAPK cascade by calcium mobilization assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	CHEMBL253811	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of MAPK cascade by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of MAPK cascade by calcium mobilization assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	216	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of intracellular calcium level by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of intracellular calcium level by calcium mobilization assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	9815618	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of intracellular calcium level by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of intracellular calcium level by calcium mobilization assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	CHEMBL253811	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of intracellular calcium level by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of intracellular calcium level by calcium mobilization assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	216	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of phospho-inositide hydrolysis by IP hydrolysis assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of phospho-inositide hydrolysis by IP hydrolysis assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	9815618	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of phospho-inositide hydrolysis by IP hydrolysis assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of phospho-inositide hydrolysis by IP hydrolysis assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	CHEMBL253811	2860	None	26	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of phospho-inositide hydrolysis by IP hydrolysis assayAgonist activity at 5-HT2B receptor (unknown origin) assessed as stimulation of phospho-inositide hydrolysis by IP hydrolysis assay	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/acs.jmedchem.3c01178
	44431701	88178	None	0	Rat	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234682	88178	None	0	Rat	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	44409290	74677	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203013	74677	None	0	Human	Functional	pEC50	=	7.6	7.6	-1	2	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	10017556	161972	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL415029	161972	None	0	Human	Functional	pEC50	=	6.6	6.6	-3	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733760	120702	None	1	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416032	120702	None	1	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546869	120702	None	1	Human	Functional	pEC50	=	5.6	5.6	-3	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11630623	89133	None	0	Human	Functional	pEC50	=	5.6	5.6	-213	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	89133	None	0	Human	Functional	pEC50	=	5.6	5.6	-213	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	89133	None	0	Human	Functional	pEC50	=	5.6	5.6	-213	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	58911653	91150	None	0	Human	Functional	pEC50	=	5.6	5.6	-25	2	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397911	91150	None	0	Human	Functional	pEC50	=	5.6	5.6	-25	2	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	168291896	193094	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	193094	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	193094	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	145	140	None	16	Rat	Functional	pEC50	=	6.6	6.6	-123	12	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	1832	140	None	16	Rat	Functional	pEC50	=	6.6	6.6	-123	12	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	CHEMBL7257	140	None	16	Rat	Functional	pEC50	=	6.6	6.6	-123	12	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	DB14010	140	None	16	Rat	Functional	pEC50	=	6.6	6.6	-123	12	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	25070911	111734	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	2	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	CHEMBL3286564	111734	None	0	Human	Functional	pEC50	=	6.6	6.6	-7	2	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	168291564	193092	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	193092	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	193092	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	168291896	193094	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	193094	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	193094	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442250	138431	None	0	Human	Functional	pEC50	=	7.6	7.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138431	None	0	Human	Functional	pEC50	=	7.6	7.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138431	None	0	Human	Functional	pEC50	=	7.6	7.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	5	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	5202	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	DB08839	139	None	45	Human	Functional	pEC50	=	7.6	7.6	-2	26	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	168291564	193092	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	193092	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	193092	None	0	Human	Functional	pEC50	=	7.6	7.6	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442250	138431	None	0	Human	Functional	pEC50	=	7.6	7.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138431	None	0	Human	Functional	pEC50	=	7.6	7.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138431	None	0	Human	Functional	pEC50	=	7.6	7.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773816	94909	None	0	Human	Functional	pEC50	=	6.6	6.6	-31	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253805	94909	None	0	Human	Functional	pEC50	=	6.6	6.6	-31	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773814	94912	None	1	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253809	94912	None	1	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11264345	130467	None	3	Human	Functional	pEC50	=	5.6	5.6	-120	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL368016	130467	None	3	Human	Functional	pEC50	=	5.6	5.6	-120	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	122442300	138436	None	0	Human	Functional	pEC50	=	5.6	5.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138436	None	0	Human	Functional	pEC50	=	5.6	5.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138436	None	0	Human	Functional	pEC50	=	5.6	5.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	122442300	138436	None	0	Human	Functional	pEC50	=	5.6	5.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138436	None	0	Human	Functional	pEC50	=	5.6	5.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138436	None	0	Human	Functional	pEC50	=	5.6	5.6	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	146025684	183741	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183741	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183741	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183769	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183769	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183769	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025684	183741	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183741	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183741	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183769	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183769	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183769	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	45484673	201414	None	0	Human	Functional	pEC50	=	6.6	6.6	-8	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL585012	201414	None	0	Human	Functional	pEC50	=	6.6	6.6	-8	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11595191	89094	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	89094	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	89094	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	162658153	183791	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183791	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183791	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183791	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183791	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183791	None	0	Human	Functional	pEC50	=	6.6	6.6	-10	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	118736627	119063	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425759	119063	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118736631	119066	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425763	119066	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	122442270	138433	None	1	Human	Functional	pEC50	=	7.6	7.6	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138433	None	1	Human	Functional	pEC50	=	7.6	7.6	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138433	None	1	Human	Functional	pEC50	=	7.6	7.6	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442270	138433	None	1	Human	Functional	pEC50	=	7.6	7.6	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138433	None	1	Human	Functional	pEC50	=	7.6	7.6	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138433	None	1	Human	Functional	pEC50	=	7.6	7.6	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11952353	202316	None	0	Human	Functional	pEC50	=	5.6	5.6	-1905	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	202316	None	0	Human	Functional	pEC50	=	5.6	5.6	-1905	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	11171955	91127	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397888	91127	None	0	Human	Functional	pEC50	=	6.6	6.6	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	44573002	12690	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL1187408	12690	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL501854	12690	None	0	Human	Functional	pEC50	=	5.6	5.6	-19	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	16115511	84871	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84871	None	0	Human	Functional	pEC50	=	6.6	6.6	-6	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	162643473	183721	None	0	Human	Functional	pEC50	=	6.6	6.6	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183721	None	0	Human	Functional	pEC50	=	6.6	6.6	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183721	None	0	Human	Functional	pEC50	=	6.6	6.6	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	172466550	196777	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at 5-HT2B (unknown origin)Agonist activity at 5-HT2B (unknown origin)	ChEMBL	271	0	2	2	3.5	Oc1cc2c3c(c1Cl)-c1ccccc1CC3NCC2	10.1016/j.ejmech.2023.115414
	CHEMBL5432040	196777	None	0	Human	Functional	pEC50	=	6.6	6.6	-12	3	Agonist activity at 5-HT2B (unknown origin)Agonist activity at 5-HT2B (unknown origin)	ChEMBL	271	0	2	2	3.5	Oc1cc2c3c(c1Cl)-c1ccccc1CC3NCC2	10.1016/j.ejmech.2023.115414
	162643473	183721	None	0	Human	Functional	pEC50	=	6.6	6.6	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183721	None	0	Human	Functional	pEC50	=	6.6	6.6	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183721	None	0	Human	Functional	pEC50	=	6.6	6.6	-14	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11300712	141773	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141773	None	0	Human	Functional	pEC50	=	7.6	7.6	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44573018	12648	None	0	Human	Functional	pEC50	=	7.6	7.6	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL1187169	12648	None	0	Human	Functional	pEC50	=	7.6	7.6	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL492306	12648	None	0	Human	Functional	pEC50	=	7.6	7.6	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	24826869	91136	None	0	Human	Functional	pEC50	=	7.6	7.6	-7	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	91136	None	0	Human	Functional	pEC50	=	7.6	7.6	-7	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	16115654	137061	None	0	Human	Functional	pEC50	=	6.6	6.6	-46	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	137061	None	0	Human	Functional	pEC50	=	6.6	6.6	-46	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53324629	56815	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643672	56815	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	1355	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	1355	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	2011	None	45	Human	Functional	pEC50	=	6.5	6.5	-5	6	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	172467762	196799	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	3	Agonist activity at 5HT2B (unknown origin)Agonist activity at 5HT2B (unknown origin)	ChEMBL	235	5	1	2	2.7	NC[C@@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1016/j.bmcl.2024.129654
	CHEMBL5432445	196799	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	3	Agonist activity at 5HT2B (unknown origin)Agonist activity at 5HT2B (unknown origin)	ChEMBL	235	5	1	2	2.7	NC[C@@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1016/j.bmcl.2024.129654
	46937339	74235	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2023357	74235	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	46937339	74235	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL2023357	74235	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	16115392	84831	None	0	Human	Functional	pEC50	=	6.5	6.5	-5	2	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223292	84831	None	0	Human	Functional	pEC50	=	6.5	6.5	-5	2	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	16115388	137453	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	137453	None	0	Human	Functional	pEC50	=	6.5	6.5	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	11209786	137327	None	0	Human	Functional	pEC50	=	5.5	5.5	-208	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	137327	None	0	Human	Functional	pEC50	=	5.5	5.5	-208	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	9859257	207581	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	207581	None	0	Human	Functional	pEC50	=	8.5	8.5	1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	168268877	190079	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	190079	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168268877	190079	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	190079	None	0	Human	Functional	pEC50	=	8.5	8.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	230	4119	None	22	Human	Functional	pEC50	=	8.5	8.5	-3	3	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	3045225	4119	None	22	Human	Functional	pEC50	=	8.5	8.5	-3	3	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	CHEMBL407909	4119	None	22	Human	Functional	pEC50	=	8.5	8.5	-3	3	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	5	139	None	45	Rat	Functional	pEC50	=	8.5	8.5	-7	26	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	5202	139	None	45	Rat	Functional	pEC50	=	8.5	8.5	-7	26	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	CHEMBL39	139	None	45	Rat	Functional	pEC50	=	8.5	8.5	-7	26	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	DB08839	139	None	45	Rat	Functional	pEC50	=	8.5	8.5	-7	26	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	44572798	12654	None	1	Human	Functional	pEC50	=	8.4	8.4	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL1187187	12654	None	1	Human	Functional	pEC50	=	8.4	8.4	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL492926	12654	None	1	Human	Functional	pEC50	=	8.4	8.4	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	46933845	16169	None	0	Human	Functional	pEC50	=	8.4	8.4	-18	2	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16169	None	0	Human	Functional	pEC50	=	8.4	8.4	-18	2	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	54583743	61483	None	0	Human	Functional	pEC50	=	7.5	7.5	5	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770382	61483	None	0	Human	Functional	pEC50	=	7.5	7.5	5	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	118736630	119065	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425762	119065	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	122442263	138444	None	0	Human	Functional	pEC50	=	7.5	7.5	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	7.5	7.5	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	7.5	7.5	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44389646	64904	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL182184	64904	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	122442263	138444	None	0	Human	Functional	pEC50	=	7.5	7.5	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	7.5	7.5	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	7.5	7.5	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442260	138441	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138441	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138441	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11949712	204618	None	0	Human	Functional	pEC50	=	6.5	6.5	-3019	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL609306	204618	None	0	Human	Functional	pEC50	=	6.5	6.5	-3019	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	118733764	120709	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416034	120709	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546890	120709	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	118733776	120715	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416040	120715	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546903	120715	None	0	Human	Functional	pEC50	=	5.5	5.5	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	70687695	74504	None	0	Human	Functional	pEC50	=	6.5	6.5	-12	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022186	74504	None	0	Human	Functional	pEC50	=	6.5	6.5	-12	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027987	74504	None	0	Human	Functional	pEC50	=	6.5	6.5	-12	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	134265675	164462	None	0	Human	Functional	pEC50	=	6.5	6.5	-40	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4212834	164462	None	0	Human	Functional	pEC50	=	6.5	6.5	-40	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162645074	183730	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183730	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183730	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162645074	183730	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183730	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183730	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11400855	12458	None	6	Human	Functional	pEC50	=	5.5	5.5	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186092	12458	None	6	Human	Functional	pEC50	=	5.5	5.5	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL449134	12458	None	6	Human	Functional	pEC50	=	5.5	5.5	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	57799306	89143	None	0	Human	Functional	pEC50	=	7.5	7.5	-12	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	89143	None	0	Human	Functional	pEC50	=	7.5	7.5	-12	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	89143	None	0	Human	Functional	pEC50	=	7.5	7.5	-12	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	122442260	138441	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138441	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138441	None	0	Human	Functional	pEC50	=	7.5	7.5	-2	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44315697	207963	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	207963	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	168268736	192898	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192898	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192898	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	9990808	122838	None	0	Human	Functional	pEC50	=	6.5	6.5	-51	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	CHEMBL360492	122838	None	0	Human	Functional	pEC50	=	6.5	6.5	-51	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	168268736	192898	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192898	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192898	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	11652452	89160	None	0	Human	Functional	pEC50	=	7.5	7.5	-9	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	89160	None	0	Human	Functional	pEC50	=	7.5	7.5	-9	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	89160	None	0	Human	Functional	pEC50	=	7.5	7.5	-9	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	44572749	12441	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL1185954	12441	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL443128	12441	None	0	Human	Functional	pEC50	=	7.5	7.5	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	44412150	77762	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL208936	77762	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	11658860	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.5	6.5	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	122442250	138431	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138431	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138431	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115644	137047	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	137047	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	118736628	119064	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425760	119064	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573230	187399	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492910	187399	None	0	Human	Functional	pEC50	=	7.5	7.5	-3	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	3356430	193155	None	0	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193155	None	0	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193155	None	0	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	70683433	74484	None	0	Human	Functional	pEC50	=	6.5	6.5	-18	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022185	74484	None	0	Human	Functional	pEC50	=	6.5	6.5	-18	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027895	74484	None	0	Human	Functional	pEC50	=	6.5	6.5	-18	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	122442250	138431	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138431	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138431	None	0	Human	Functional	pEC50	=	6.5	6.5	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138430	None	0	Human	Functional	pEC50	=	5.5	5.5	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138430	None	0	Human	Functional	pEC50	=	5.5	5.5	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138430	None	0	Human	Functional	pEC50	=	5.5	5.5	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138430	None	0	Human	Functional	pEC50	=	5.5	5.5	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138430	None	0	Human	Functional	pEC50	=	5.5	5.5	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138430	None	0	Human	Functional	pEC50	=	5.5	5.5	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573016	12674	None	0	Human	Functional	pEC50	=	5.5	5.5	-38	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL1187322	12674	None	0	Human	Functional	pEC50	=	5.5	5.5	-38	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL498863	12674	None	0	Human	Functional	pEC50	=	5.5	5.5	-38	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	168272608	192902	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192902	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192902	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162657053	183787	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183787	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183787	None	0	Human	Functional	pEC50	=	6.5	6.5	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168272608	192902	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192902	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192902	None	0	Human	Functional	pEC50	=	6.5	6.5	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	3356430	193155	None	0	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193155	None	0	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193155	None	0	Human	Functional	pEC50	=	7.5	7.5	2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44573222	174416	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL455039	174416	None	0	Human	Functional	pEC50	=	7.5	7.5	2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	22241625	196520	None	0	Human	Functional	pEC50	=	7.5	7.5	3	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	CHEMBL5425772	196520	None	0	Human	Functional	pEC50	=	7.5	7.5	3	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	118733766	120703	None	0	Human	Functional	pEC50	=	5.5	5.5	-33	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416035	120703	None	0	Human	Functional	pEC50	=	5.5	5.5	-33	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546870	120703	None	0	Human	Functional	pEC50	=	5.5	5.5	-33	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	146025686	183865	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183865	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183865	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	146025686	183865	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183865	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183865	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	22241625	196520	None	0	Human	Functional	pEC50	=	7.5	7.5	3	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	CHEMBL5425772	196520	None	0	Human	Functional	pEC50	=	7.5	7.5	3	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	205	3	2	3	1.4	CN(C)CCc1n[nH]c2ccc(O)cc12	10.1021/acsmedchemlett.3c00566
	44572757	12653	None	0	Human	Functional	pEC50	=	6.5	6.5	-7	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL1187186	12653	None	0	Human	Functional	pEC50	=	6.5	6.5	-7	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL492917	12653	None	0	Human	Functional	pEC50	=	6.5	6.5	-7	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	45484742	200974	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	CHEMBL577903	200974	None	0	Human	Functional	pEC50	=	6.5	6.5	-1	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	122442286	138438	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	138438	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	6.5	6.5	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573221	193189	None	0	Human	Functional	pEC50	=	6.5	6.5	-7	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL522514	193189	None	0	Human	Functional	pEC50	=	6.5	6.5	-7	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	44622848	193456	None	0	Human	Functional	pEC50	=	6.5	6.5	-11	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL524778	193456	None	0	Human	Functional	pEC50	=	6.5	6.5	-11	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	9881119	207931	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	207931	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	9990808	122838	None	0	Human	Functional	pEC50	=	6.4	6.4	-51	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL360492	122838	None	0	Human	Functional	pEC50	=	6.4	6.4	-51	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	44573012	12647	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL1187168	12647	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL492305	12647	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	11206703	91126	None	0	Human	Functional	pEC50	=	7.4	7.4	-12	3	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	91126	None	0	Human	Functional	pEC50	=	7.4	7.4	-12	3	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	44572657	12471	None	5	Human	Functional	pEC50	=	7.4	7.4	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186169	12471	None	5	Human	Functional	pEC50	=	7.4	7.4	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL452719	12471	None	5	Human	Functional	pEC50	=	7.4	7.4	-7	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	44573004	12524	None	0	Human	Functional	pEC50	=	7.4	7.4	3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL1186590	12524	None	0	Human	Functional	pEC50	=	7.4	7.4	3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL471202	12524	None	0	Human	Functional	pEC50	=	7.4	7.4	3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	53325938	56822	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643679	56822	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	10105208	62519	None	0	Human	Functional	pEC50	=	6.4	6.4	-83	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178124	62519	None	0	Human	Functional	pEC50	=	6.4	6.4	-83	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	1355	2011	None	45	Human	Functional	pEC50	=	7.4	7.4	-5	6	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	142	2011	None	45	Human	Functional	pEC50	=	7.4	7.4	-5	6	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	CHEMBL478	2011	None	45	Human	Functional	pEC50	=	7.4	7.4	-5	6	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	DB12110	2011	None	45	Human	Functional	pEC50	=	7.4	7.4	-5	6	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	24773649	94880	None	0	Human	Functional	pEC50	=	7.4	7.4	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253591	94880	None	0	Human	Functional	pEC50	=	7.4	7.4	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773651	154947	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	CHEMBL400600	154947	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	46228437	202440	None	1	Human	Functional	pEC50	=	6.4	6.4	-39	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595194	202440	None	1	Human	Functional	pEC50	=	6.4	6.4	-39	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	24773895	94910	None	0	Human	Functional	pEC50	=	6.4	6.4	-50	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL253806	94910	None	0	Human	Functional	pEC50	=	6.4	6.4	-50	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	122442270	138433	None	1	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138433	None	1	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138433	None	1	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773979	130237	None	20	Human	Functional	pEC50	=	5.4	5.4	-12	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	CHEMBL367796	130237	None	20	Human	Functional	pEC50	=	5.4	5.4	-12	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	11264955	207419	None	0	Human	Functional	pEC50	=	8.4	8.4	1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	207419	None	0	Human	Functional	pEC50	=	8.4	8.4	1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	152	364	None	24	Rat	Functional	pEC50	=	8.4	8.4	-2	5	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	2107	364	None	24	Rat	Functional	pEC50	=	8.4	8.4	-2	5	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	CHEMBL275854	364	None	24	Rat	Functional	pEC50	=	8.4	8.4	-2	5	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	11708275	72737	None	1	Rat	Functional	pEC50	=	8.4	8.4	1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	CHEMBL199775	72737	None	1	Rat	Functional	pEC50	=	8.4	8.4	1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	166	3359	None	19	Human	Functional	pEC50	=	8.4	8.4	2	5	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3359	None	19	Human	Functional	pEC50	=	8.4	8.4	2	5	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3359	None	19	Human	Functional	pEC50	=	8.4	8.4	2	5	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	5	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-2	26	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	5202	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-2	26	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-2	26	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	DB08839	139	None	45	Human	Functional	pEC50	=	8.4	8.4	-2	26	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	16047544	12652	None	5	Human	Functional	pEC50	=	8.3	8.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12652	None	5	Human	Functional	pEC50	=	8.3	8.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12652	None	5	Human	Functional	pEC50	=	8.3	8.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	44572172	12550	None	0	Human	Functional	pEC50	=	8.3	8.3	1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL1186686	12550	None	0	Human	Functional	pEC50	=	8.3	8.3	1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL474633	12550	None	0	Human	Functional	pEC50	=	8.3	8.3	1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	16115267	84827	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84827	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9994008	166244	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL426235	166244	None	0	Human	Functional	pEC50	=	7.4	7.4	-3	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	122442270	138433	None	1	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138433	None	1	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138433	None	1	Human	Functional	pEC50	=	6.4	6.4	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	22368315	63787	None	0	Human	Functional	pEC50	=	6.4	6.4	-50	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180166	63787	None	0	Human	Functional	pEC50	=	6.4	6.4	-50	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	134265618	164150	None	0	Human	Functional	pEC50	=	5.4	5.4	-323	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4209052	164150	None	0	Human	Functional	pEC50	=	5.4	5.4	-323	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	46884138	8445	None	0	Human	Functional	pEC50	=	5.4	5.4	-812	3	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093699	8445	None	0	Human	Functional	pEC50	=	5.4	5.4	-812	3	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	44572812	12518	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL1186561	12518	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL469729	12518	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	54587669	61480	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770379	61480	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11609026	89161	None	0	Human	Functional	pEC50	=	6.4	6.4	-125	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	89161	None	0	Human	Functional	pEC50	=	6.4	6.4	-125	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	89161	None	0	Human	Functional	pEC50	=	6.4	6.4	-125	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	44573014	12525	None	0	Human	Functional	pEC50	=	6.4	6.4	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL1186595	12525	None	0	Human	Functional	pEC50	=	6.4	6.4	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL471802	12525	None	0	Human	Functional	pEC50	=	6.4	6.4	-10	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	3568128	193042	None	0	Human	Functional	pEC50	=	6.4	6.4	4	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	193042	None	0	Human	Functional	pEC50	=	6.4	6.4	4	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	193042	None	0	Human	Functional	pEC50	=	6.4	6.4	4	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	3568128	193042	None	0	Human	Functional	pEC50	=	6.4	6.4	4	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	193042	None	0	Human	Functional	pEC50	=	6.4	6.4	4	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	193042	None	0	Human	Functional	pEC50	=	6.4	6.4	4	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	44420682	137695	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137695	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	118733802	120717	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416053	120717	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546905	120717	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168284548	193020	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	193020	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	193020	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	168284548	193020	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	193020	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	193020	None	0	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	118733788	120728	None	0	Human	Functional	pEC50	=	5.4	5.4	-5	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416046	120728	None	0	Human	Functional	pEC50	=	5.4	5.4	-5	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546955	120728	None	0	Human	Functional	pEC50	=	5.4	5.4	-5	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11658860	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183823	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183823	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183823	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11658860	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.4	6.4	-35	11	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183823	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183823	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183823	None	0	Human	Functional	pEC50	=	6.4	6.4	-17	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733792	120736	None	0	Human	Functional	pEC50	=	5.4	5.4	-12	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416048	120736	None	0	Human	Functional	pEC50	=	5.4	5.4	-12	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546974	120736	None	0	Human	Functional	pEC50	=	5.4	5.4	-12	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	162659286	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	122442266	138430	None	0	Human	Functional	pEC50	=	5.4	5.4	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138430	None	0	Human	Functional	pEC50	=	5.4	5.4	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138430	None	0	Human	Functional	pEC50	=	5.4	5.4	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138430	None	0	Human	Functional	pEC50	=	5.4	5.4	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138430	None	0	Human	Functional	pEC50	=	5.4	5.4	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138430	None	0	Human	Functional	pEC50	=	5.4	5.4	-51	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162659286	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183801	None	0	Human	Functional	pEC50	=	6.4	6.4	-13	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	146025687	183821	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183821	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183821	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	118733804	120718	None	0	Human	Functional	pEC50	=	5.3	5.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416054	120718	None	0	Human	Functional	pEC50	=	5.3	5.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546906	120718	None	0	Human	Functional	pEC50	=	5.3	5.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	162668367	183845	None	0	Human	Functional	pEC50	=	6.3	6.3	-21	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183845	None	0	Human	Functional	pEC50	=	6.3	6.3	-21	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183845	None	0	Human	Functional	pEC50	=	6.3	6.3	-21	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442309	138434	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138434	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138434	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	168294156	193114	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193114	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193114	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	162668367	183845	None	0	Human	Functional	pEC50	=	6.3	6.3	-21	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183845	None	0	Human	Functional	pEC50	=	6.3	6.3	-21	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183845	None	0	Human	Functional	pEC50	=	6.3	6.3	-21	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	168294156	193114	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	193114	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	193114	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442254	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442309	138434	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138434	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138434	None	0	Human	Functional	pEC50	=	6.3	6.3	-6	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572164	12687	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL1187390	12687	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL501526	12687	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	146025687	183821	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183821	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183821	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	46230099	201768	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	201768	None	0	Human	Functional	pEC50	=	7.3	7.3	-25	3	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	118733794	120737	None	0	Human	Functional	pEC50	=	5.3	5.3	-72	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416049	120737	None	0	Human	Functional	pEC50	=	5.3	5.3	-72	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546975	120737	None	0	Human	Functional	pEC50	=	5.3	5.3	-72	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	122442254	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138432	None	0	Human	Functional	pEC50	=	6.3	6.3	-26	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	138438	None	0	Human	Functional	pEC50	=	6.3	6.3	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138438	None	0	Human	Functional	pEC50	=	6.3	6.3	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138438	None	0	Human	Functional	pEC50	=	6.3	6.3	-34	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	57469772	195096	None	1	Human	Functional	pEC50	=	6.3	6.3	-3	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1OC1(C=C2)CCNCC1	10.1021/acsmedchemlett.3c00454
	CHEMBL5396618	195096	None	1	Human	Functional	pEC50	=	6.3	6.3	-3	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1OC1(C=C2)CCNCC1	10.1021/acsmedchemlett.3c00454
	45484682	200827	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL576651	200827	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11658860	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	44573153	187303	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492348	187303	None	0	Human	Functional	pEC50	=	6.3	6.3	1	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44573157	187404	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492950	187404	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	134265622	164848	None	0	Human	Functional	pEC50	=	6.3	6.3	-81	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4217787	164848	None	0	Human	Functional	pEC50	=	6.3	6.3	-81	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	85542158	195546	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	44412388	78214	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210484	78214	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	85542158	195546	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5405688	195546	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5439312	195546	None	0	Human	Functional	pEC50	=	6.3	6.3	1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	219	4	1	3	1.7	COc1ccc2[nH]nc(CCN(C)C)c2c1	10.1021/acsmedchemlett.3c00566
	145966293	164549	None	0	Human	Functional	pEC50	=	6.3	6.3	-14	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4213971	164549	None	0	Human	Functional	pEC50	=	6.3	6.3	-14	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	18735309	207891	None	0	Human	Functional	pEC50	=	7.3	7.3	2	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	207891	None	0	Human	Functional	pEC50	=	7.3	7.3	2	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	118733814	120722	None	0	Human	Functional	pEC50	=	5.3	5.3	-23	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416059	120722	None	0	Human	Functional	pEC50	=	5.3	5.3	-23	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546910	120722	None	0	Human	Functional	pEC50	=	5.3	5.3	-23	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	44572761	12684	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL1187377	12684	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL501117	12684	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	11302765	84282	None	4	Human	Functional	pEC50	=	5.3	5.3	-309	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	84282	None	4	Human	Functional	pEC50	=	5.3	5.3	-309	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11448649	83465	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83465	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	50878551	90779	None	28	Human	Functional	pEC50	=	8.3	8.3	1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90779	None	28	Human	Functional	pEC50	=	8.3	8.3	1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	50878551	90779	None	28	Human	Functional	pEC50	=	8.3	8.3	1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90779	None	28	Human	Functional	pEC50	=	8.3	8.3	1	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	44572808	12710	None	0	Human	Functional	pEC50	=	8.3	8.3	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL1187585	12710	None	0	Human	Functional	pEC50	=	8.3	8.3	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL510383	12710	None	0	Human	Functional	pEC50	=	8.3	8.3	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	170453288	196449	None	2	Human	Functional	pEC50	=	8.3	8.3	6	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	CHEMBL5424175	196449	None	2	Human	Functional	pEC50	=	8.3	8.3	6	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	277	1	2	2	2.7	Brc1ccc2[nH]nc(C3=CCCNC3)c2c1	10.1021/acsmedchemlett.3c00566
	44431688	152829	None	0	Rat	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL397321	152829	None	0	Rat	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	5	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-2	26	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	5202	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-2	26	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	CHEMBL39	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-2	26	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	DB08839	139	None	45	Human	Functional	pEC50	=	8.2	8.2	-2	26	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	145	140	None	16	Human	Functional	pEC50	=	8.2	8.2	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	1832	140	None	16	Human	Functional	pEC50	=	8.2	8.2	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	CHEMBL7257	140	None	16	Human	Functional	pEC50	=	8.2	8.2	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	DB14010	140	None	16	Human	Functional	pEC50	=	8.2	8.2	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	135509961	136216	None	1	Rat	Functional	pEC50	=	8.2	8.2	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	CHEMBL373245	136216	None	1	Rat	Functional	pEC50	=	8.2	8.2	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	9991444	62652	None	1	Human	Functional	pEC50	=	7.3	7.3	-15	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL178366	62652	None	1	Human	Functional	pEC50	=	7.3	7.3	-15	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	154699445	177531	None	0	Human	Functional	pEC50	=	4.3	4.3	-	1	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	177531	None	0	Human	Functional	pEC50	=	4.3	4.3	-	1	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	11737032	85050	None	0	Human	Functional	pEC50	=	6.3	6.3	-13	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	85050	None	0	Human	Functional	pEC50	=	6.3	6.3	-13	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	162674022	183327	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	183327	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	22292784	64615	None	16	Human	Functional	pEC50	=	6.3	6.3	-17	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	CHEMBL181672	64615	None	16	Human	Functional	pEC50	=	6.3	6.3	-17	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	24773809	94935	None	0	Human	Functional	pEC50	=	6.3	6.3	-63	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254009	94935	None	0	Human	Functional	pEC50	=	6.3	6.3	-63	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	122442300	138436	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138436	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138436	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	57469772	195096	None	1	Human	Functional	pEC50	=	6.3	6.3	-3	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1OC1(C=C2)CCNCC1	10.1021/acsmedchemlett.3c00454
	CHEMBL5396618	195096	None	1	Human	Functional	pEC50	=	6.3	6.3	-3	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1OC1(C=C2)CCNCC1	10.1021/acsmedchemlett.3c00454
	24773900	123499	None	6	Human	Functional	pEC50	=	5.3	5.3	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	CHEMBL361742	123499	None	6	Human	Functional	pEC50	=	5.3	5.3	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	118733778	120724	None	0	Human	Functional	pEC50	=	5.3	5.3	-19	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416041	120724	None	0	Human	Functional	pEC50	=	5.3	5.3	-19	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546951	120724	None	0	Human	Functional	pEC50	=	5.3	5.3	-19	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	50942111	56863	None	0	Human	Functional	pEC50	=	6.3	6.3	-5	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643854	56863	None	0	Human	Functional	pEC50	=	6.3	6.3	-5	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	45485725	200283	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572252	200283	None	0	Human	Functional	pEC50	=	6.3	6.3	-19	3	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	122442300	138436	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138436	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138436	None	0	Human	Functional	pEC50	=	6.3	6.3	-8	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572698	12556	None	0	Human	Functional	pEC50	=	6.3	6.3	5	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL1186700	12556	None	0	Human	Functional	pEC50	=	6.3	6.3	5	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL474885	12556	None	0	Human	Functional	pEC50	=	6.3	6.3	5	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	162652562	183763	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183763	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183763	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	11658860	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.3	6.3	-35	11	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	172444062	195485	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	CHEMBL5404610	195485	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	11666237	89146	None	0	Human	Functional	pEC50	=	6.3	6.3	-30	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	89146	None	0	Human	Functional	pEC50	=	6.3	6.3	-30	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	89146	None	0	Human	Functional	pEC50	=	6.3	6.3	-30	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	162652562	183763	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183763	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183763	None	0	Human	Functional	pEC50	=	6.3	6.3	-4	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	172444062	195485	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	CHEMBL5404610	195485	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	213	1	1	3	2.0	Cn1nc(C2=CCCNC2)c2ccccc21	10.1021/acsmedchemlett.3c00566
	44572755	12463	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186115	12463	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL450599	12463	None	0	Human	Functional	pEC50	=	7.3	7.3	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	22292784	64615	None	16	Human	Functional	pEC50	=	6.3	6.3	-17	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181672	64615	None	16	Human	Functional	pEC50	=	6.3	6.3	-17	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	118733780	120704	None	0	Human	Functional	pEC50	=	5.3	5.3	-7	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416042	120704	None	0	Human	Functional	pEC50	=	5.3	5.3	-7	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546871	120704	None	0	Human	Functional	pEC50	=	5.3	5.3	-7	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	3572096	193007	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	193007	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	193007	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	3572096	193007	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	193007	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	193007	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	162670523	183856	None	0	Human	Functional	pEC50	=	7.3	7.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183856	None	0	Human	Functional	pEC50	=	7.3	7.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183856	None	0	Human	Functional	pEC50	=	7.3	7.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025688	183800	None	0	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183800	None	0	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183800	None	0	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	146025688	183800	None	0	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183800	None	0	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183800	None	0	Human	Functional	pEC50	=	6.3	6.3	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	11313985	91117	None	0	Human	Functional	pEC50	=	7.3	7.3	-18	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	91117	None	0	Human	Functional	pEC50	=	7.3	7.3	-18	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	11949710	202358	None	0	Human	Functional	pEC50	=	6.3	6.3	-50	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	202358	None	0	Human	Functional	pEC50	=	6.3	6.3	-50	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	118733772	120712	None	0	Human	Functional	pEC50	=	5.3	5.3	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416038	120712	None	0	Human	Functional	pEC50	=	5.3	5.3	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546893	120712	None	0	Human	Functional	pEC50	=	5.3	5.3	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11737939	84261	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL220900	84261	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	11291	3220	None	14	Human	Functional	pEC50	=	7.2	7.2	1	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	4980	3220	None	14	Human	Functional	pEC50	=	7.2	7.2	1	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	CHEMBL65547	3220	None	14	Human	Functional	pEC50	=	7.2	7.2	1	4	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	162670523	183856	None	0	Human	Functional	pEC50	=	7.2	7.2	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183856	None	0	Human	Functional	pEC50	=	7.2	7.2	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183856	None	0	Human	Functional	pEC50	=	7.2	7.2	-20	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	168283046	193001	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	193001	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	193001	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162676809	183898	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183898	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183898	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	193043	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	193043	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	193043	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	162676809	183898	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183898	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183898	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	193043	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	193043	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	193043	None	0	Human	Functional	pEC50	=	6.2	6.2	2	2	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	44431689	87283	None	0	Rat	Functional	pEC50	=	7.2	7.2	-13	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL232995	87283	None	0	Rat	Functional	pEC50	=	7.2	7.2	-13	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	44572800	12657	None	2	Human	Functional	pEC50	=	7.2	7.2	-5	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL1187194	12657	None	2	Human	Functional	pEC50	=	7.2	7.2	-5	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL493128	12657	None	2	Human	Functional	pEC50	=	7.2	7.2	-5	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	168283046	193001	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	193001	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	193001	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	44412403	77827	None	0	Human	Functional	pEC50	=	7.2	7.2	7	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209254	77827	None	0	Human	Functional	pEC50	=	7.2	7.2	7	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	135399866	72079	None	1	Rat	Functional	pEC50	=	8.2	8.2	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	CHEMBL197653	72079	None	1	Rat	Functional	pEC50	=	8.2	8.2	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	44431705	145214	None	0	Rat	Functional	pEC50	=	8.2	8.2	6	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL391196	145214	None	0	Rat	Functional	pEC50	=	8.2	8.2	6	2	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	18735313	207392	None	1	Human	Functional	pEC50	=	8.2	8.2	6	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	207392	None	1	Human	Functional	pEC50	=	8.2	8.2	6	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	162650400	183755	None	0	Human	Functional	pEC50	=	7.2	7.2	-22	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183755	None	0	Human	Functional	pEC50	=	7.2	7.2	-22	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183755	None	0	Human	Functional	pEC50	=	7.2	7.2	-22	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	54581791	61484	None	0	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770383	61484	None	0	Human	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	162650400	183755	None	0	Human	Functional	pEC50	=	7.2	7.2	-22	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183755	None	0	Human	Functional	pEC50	=	7.2	7.2	-22	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183755	None	0	Human	Functional	pEC50	=	7.2	7.2	-22	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	53324165	56817	None	0	Human	Functional	pEC50	=	6.2	6.2	-9	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643674	56817	None	0	Human	Functional	pEC50	=	6.2	6.2	-9	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	122442263	138444	None	0	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442263	138444	None	0	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138444	None	0	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138444	None	0	Human	Functional	pEC50	=	6.2	6.2	-30	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733800	120716	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416052	120716	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546904	120716	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	46230098	201785	None	0	Human	Functional	pEC50	=	7.2	7.2	-30	4	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	201785	None	0	Human	Functional	pEC50	=	7.2	7.2	-30	4	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	134265705	164186	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4209572	164186	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	54584721	61478	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770377	61478	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	118733812	120706	None	0	Human	Functional	pEC50	=	5.2	5.2	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416058	120706	None	0	Human	Functional	pEC50	=	5.2	5.2	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546873	120706	None	0	Human	Functional	pEC50	=	5.2	5.2	-4	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	24849050	78331	None	1	Human	Functional	pEC50	=	7.2	7.2	-2	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210802	78331	None	1	Human	Functional	pEC50	=	7.2	7.2	-2	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	10036629	64658	None	0	Human	Functional	pEC50	=	7.2	7.2	-9	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	CHEMBL181787	64658	None	0	Human	Functional	pEC50	=	7.2	7.2	-9	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	149663072	196095	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1C=CC1(CCNCC1)O2	10.1021/acsmedchemlett.3c00454
	CHEMBL5416800	196095	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1C=CC1(CCNCC1)O2	10.1021/acsmedchemlett.3c00454
	24773728	94913	None	0	Human	Functional	pEC50	=	6.2	6.2	-31	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253810	94913	None	0	Human	Functional	pEC50	=	6.2	6.2	-31	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	118733806	120719	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416055	120719	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546907	120719	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	10064386	63337	None	2	Human	Functional	pEC50	=	7.2	7.2	-32	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179378	63337	None	2	Human	Functional	pEC50	=	7.2	7.2	-32	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44572802	12448	None	1	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12448	None	1	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12448	None	1	Human	Functional	pEC50	=	7.2	7.2	-13	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	11983273	78025	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209714	78025	None	0	Human	Functional	pEC50	=	7.2	7.2	1	3	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	149663072	196095	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1C=CC1(CCNCC1)O2	10.1021/acsmedchemlett.3c00454
	CHEMBL5416800	196095	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL	235	0	1	2	2.9	Clc1cccc2c1C=CC1(CCNCC1)O2	10.1021/acsmedchemlett.3c00454
	118733796	120705	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416050	120705	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546872	120705	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	44572747	12709	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL1187580	12709	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL510308	12709	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	44573217	187445	None	0	Human	Functional	pEC50	=	7.2	7.2	10	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493152	187445	None	0	Human	Functional	pEC50	=	7.2	7.2	10	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572174	12551	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186687	12551	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL474634	12551	None	0	Human	Functional	pEC50	=	8.2	8.2	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	44316017	207910	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	207910	None	0	Human	Functional	pEC50	=	8.1	8.1	4	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	11644842	89131	None	0	Human	Functional	pEC50	=	6.2	6.2	-12	2	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337105	89131	None	0	Human	Functional	pEC50	=	6.2	6.2	-12	2	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365394	89131	None	0	Human	Functional	pEC50	=	6.2	6.2	-12	2	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	53321865	56864	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643855	56864	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	122442273	138443	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138443	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138443	None	0	Human	Functional	pEC50	=	6.2	6.2	-5	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44316027	207980	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	207980	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	162644827	183729	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183729	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183729	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162660358	183810	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183810	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183810	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442273	138443	None	0	Human	Functional	pEC50	=	6.1	6.1	-5	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138443	None	0	Human	Functional	pEC50	=	6.1	6.1	-5	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138443	None	0	Human	Functional	pEC50	=	6.1	6.1	-5	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162644827	183729	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183729	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183729	None	0	Human	Functional	pEC50	=	6.1	6.1	-109	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	53317925	56868	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643859	56868	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	162660358	183810	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183810	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183810	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	118733816	120723	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416060	120723	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546911	120723	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	10624	70324	None	12	Human	Functional	pEC50	=	7.1	7.1	6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	10624.0	70324	None	12	Human	Functional	pEC50	=	7.1	7.1	6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	138543650	70324	None	12	Human	Functional	pEC50	=	7.1	7.1	6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194378	70324	None	12	Human	Functional	pEC50	=	7.1	7.1	6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	DB11664	70324	None	12	Human	Functional	pEC50	=	7.1	7.1	6	3	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	46228422	202492	None	0	Human	Functional	pEC50	=	6.1	6.1	-33	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595553	202492	None	0	Human	Functional	pEC50	=	6.1	6.1	-33	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44572806	12658	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1187195	12658	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL493129	12658	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	44573218	193166	None	0	Human	Functional	pEC50	=	7.1	7.1	2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL522349	193166	None	0	Human	Functional	pEC50	=	7.1	7.1	2	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1534	103095	None	23	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103095	None	23	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103095	None	23	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	1534	103095	None	23	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103095	None	23	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103095	None	23	Human	Functional	pEC50	=	7.1	7.1	-3	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	162659049	183799	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183799	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183799	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265620	164501	None	0	Human	Functional	pEC50	=	6.1	6.1	-6456	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4213379	164501	None	0	Human	Functional	pEC50	=	6.1	6.1	-6456	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162659049	183799	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183799	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183799	None	0	Human	Functional	pEC50	=	7.1	7.1	-8	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	44572804	12627	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL1187088	12627	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL490064	12627	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	162669436	183851	None	0	Human	Functional	pEC50	=	6.1	6.1	-19	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183851	None	0	Human	Functional	pEC50	=	6.1	6.1	-19	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183851	None	0	Human	Functional	pEC50	=	6.1	6.1	-19	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265590	164853	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4217846	164853	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	3	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	9991444	62652	None	1	Human	Functional	pEC50	=	7.1	7.1	-15	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178366	62652	None	1	Human	Functional	pEC50	=	7.1	7.1	-15	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	24773900	123499	None	6	Human	Functional	pEC50	=	6.1	6.1	-6	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL361742	123499	None	6	Human	Functional	pEC50	=	6.1	6.1	-6	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	162669436	183851	None	0	Human	Functional	pEC50	=	6.1	6.1	-19	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183851	None	0	Human	Functional	pEC50	=	6.1	6.1	-19	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183851	None	0	Human	Functional	pEC50	=	6.1	6.1	-19	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11658860	2344	None	24	Human	Functional	pEC50	=	6.1	6.1	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	2941	2344	None	24	Human	Functional	pEC50	=	6.1	6.1	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	4374	2344	None	24	Human	Functional	pEC50	=	6.1	6.1	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.1	6.1	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.1	6.1	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	10105208	62519	None	0	Human	Functional	pEC50	=	6.1	6.1	-83	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL178124	62519	None	0	Human	Functional	pEC50	=	6.1	6.1	-83	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	11160564	63324	None	2	Human	Functional	pEC50	=	6.1	6.1	-40	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	CHEMBL179337	63324	None	2	Human	Functional	pEC50	=	6.1	6.1	-40	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	23395431	94966	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254215	94966	None	0	Human	Functional	pEC50	=	6.1	6.1	-79	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	16115517	84872	None	0	Human	Functional	pEC50	=	8.1	8.1	-5	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84872	None	0	Human	Functional	pEC50	=	8.1	8.1	-5	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	145	140	None	16	Human	Functional	pEC50	=	8.1	8.1	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	1832	140	None	16	Human	Functional	pEC50	=	8.1	8.1	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	CHEMBL7257	140	None	16	Human	Functional	pEC50	=	8.1	8.1	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	DB14010	140	None	16	Human	Functional	pEC50	=	8.1	8.1	-3	12	Agonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assayAgonist activity at human 5-HT2B receptor expressed in Flp-In-T-REx-293 cells measured after 140 secs by Fluo-4 dye based calcium mobilization assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acsmedchemlett.3c00566
	44572178	12565	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL1186736	12565	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL475642	12565	None	0	Human	Functional	pEC50	=	8.1	8.1	-1	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	135520431	72634	None	4	Rat	Functional	pEC50	=	8.1	8.1	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL199385	72634	None	4	Rat	Functional	pEC50	=	8.1	8.1	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	135414348	72834	None	1	Rat	Functional	pEC50	=	8.1	8.1	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL200104	72834	None	1	Rat	Functional	pEC50	=	8.1	8.1	-1	2	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	44573154	187304	None	0	Human	Functional	pEC50	=	6.1	6.1	-17	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492349	187304	None	0	Human	Functional	pEC50	=	6.1	6.1	-17	2	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	45484662	200947	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577691	200947	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11231392	84928	None	0	Human	Functional	pEC50	=	6.1	6.1	-7	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84928	None	0	Human	Functional	pEC50	=	6.1	6.1	-7	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	71682217	91152	None	0	Human	Functional	pEC50	=	6.1	6.1	-10	3	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397913	91152	None	0	Human	Functional	pEC50	=	6.1	6.1	-10	3	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44572170	12469	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL1186164	12469	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL452458	12469	None	0	Human	Functional	pEC50	=	7.1	7.1	-4	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	118733810	120721	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416057	120721	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546909	120721	None	0	Human	Functional	pEC50	=	6.1	6.1	-9	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	162657367	183788	None	0	Human	Functional	pEC50	=	7.1	7.1	-32	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183788	None	0	Human	Functional	pEC50	=	7.1	7.1	-32	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183788	None	0	Human	Functional	pEC50	=	7.1	7.1	-32	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	45484700	199759	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL568692	199759	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11160564	63324	None	2	Human	Functional	pEC50	=	6.1	6.1	-40	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179337	63324	None	2	Human	Functional	pEC50	=	6.1	6.1	-40	3	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	53320653	56816	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643673	56816	None	0	Human	Functional	pEC50	=	6.1	6.1	-2	2	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	135399666	168866	None	4	Rat	Functional	pEC50	=	7.1	7.1	1	6	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168866	None	4	Rat	Functional	pEC50	=	7.1	7.1	1	6	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	12370465	12678	None	15	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL1187354	12678	None	15	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL500093	12678	None	15	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	162657367	183788	None	0	Human	Functional	pEC50	=	7.1	7.1	-32	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183788	None	0	Human	Functional	pEC50	=	7.1	7.1	-32	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183788	None	0	Human	Functional	pEC50	=	7.1	7.1	-32	3	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733762	120708	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416033	120708	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546889	120708	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	11437171	83523	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83523	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	3	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	168286640	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	193037	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168294430	193116	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193116	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193116	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168294430	193116	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	193116	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	193116	None	0	Human	Functional	pEC50	=	7.1	7.1	-1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL4913232	216564	None	7	Human	Functional	pEC50	=	6.1	6.1	-6	2	Partial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assayPartial agonist activity at human 5-HT2BR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay	ChEMBL		None	None	None		C1=CC2(CCNCC2)Oc2ccccc21	10.1021/acsmedchemlett.3c00454
	24826868	91116	None	1	Human	Functional	pEC50	=	8.1	8.1	1	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	91116	None	1	Human	Functional	pEC50	=	8.1	8.1	1	3	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	11695000	89105	None	0	Human	Functional	pEC50	=	8	8.0	-7	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89105	None	0	Human	Functional	pEC50	=	8	8.0	-7	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89105	None	0	Human	Functional	pEC50	=	8	8.0	-7	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	122461343	138449	None	0	Human	Functional	pEC50	=	6.0	6.0	-9	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138449	None	0	Human	Functional	pEC50	=	6.0	6.0	-9	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138449	None	0	Human	Functional	pEC50	=	6.0	6.0	-9	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	7153	98073	None	55	Human	Functional	pEC50	=	7.0	7.0	1	4	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	CHEMBL272942	98073	None	55	Human	Functional	pEC50	=	7.0	7.0	1	4	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	154699445	177531	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	177531	None	0	Human	Functional	pEC50	=	5.0	5.0	-	1	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	122461343	138449	None	0	Human	Functional	pEC50	=	6.0	6.0	-9	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138449	None	0	Human	Functional	pEC50	=	6.0	6.0	-9	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138449	None	0	Human	Functional	pEC50	=	6.0	6.0	-9	2	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11514226	89144	None	0	Human	Functional	pEC50	=	7.0	7.0	-85	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	89144	None	0	Human	Functional	pEC50	=	7.0	7.0	-85	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	89144	None	0	Human	Functional	pEC50	=	7.0	7.0	-85	3	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	45484661	201337	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL584210	201337	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	53325935	56813	None	0	Human	Functional	pEC50	=	7.0	7.0	-17	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643670	56813	None	0	Human	Functional	pEC50	=	7.0	7.0	-17	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	53324630	56819	None	0	Human	Functional	pEC50	=	7.0	7.0	-18	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643676	56819	None	0	Human	Functional	pEC50	=	7.0	7.0	-18	3	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	11658860	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	2941	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	4374	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	11658860	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2344	None	24	Human	Functional	pEC50	=	6.0	6.0	-35	11	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	122442275	138448	None	0	Human	Functional	pEC50	=	6.0	6.0	-11	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138448	None	0	Human	Functional	pEC50	=	6.0	6.0	-11	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138448	None	0	Human	Functional	pEC50	=	6.0	6.0	-11	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	122442275	138448	None	0	Human	Functional	pEC50	=	6.0	6.0	-11	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138448	None	0	Human	Functional	pEC50	=	6.0	6.0	-11	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138448	None	0	Human	Functional	pEC50	=	6.0	6.0	-11	3	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	168288743	193056	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	193056	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	193056	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	4543677	192899	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192899	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192899	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	4543677	192899	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192899	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192899	None	0	Human	Functional	pEC50	=	6.0	6.0	-2	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168288743	193056	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	193056	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	193056	None	0	Human	Functional	pEC50	=	7.0	7.0	1	3	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	118733774	120714	None	0	Human	Functional	pEC50	=	6	6.0	-10	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416039	120714	None	0	Human	Functional	pEC50	=	6	6.0	-10	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546902	120714	None	0	Human	Functional	pEC50	=	6	6.0	-10	3	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	46228430	202194	None	0	Human	Functional	pEC50	=	6	6.0	-8	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL593545	202194	None	0	Human	Functional	pEC50	=	6	6.0	-8	3	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44138039	179395	None	8	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	179395	None	8	Human	Functional	pIC50	=	9.7	9.7	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565847	180675	None	0	Human	Functional	pIC50	=	9.5	9.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	180675	None	0	Human	Functional	pIC50	=	9.5	9.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	9929424	210338	None	7	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	336	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)cc1OC	10.1021/acs.jmedchem.3c00734
	CHEMBL5419724	210338	None	7	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	336	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)cc1OC	10.1021/acs.jmedchem.3c00734
	CHEMBL96559	210338	None	7	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	336	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)cc1OC	10.1021/acs.jmedchem.3c00734
	44565831	180542	None	0	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	180542	None	0	Human	Functional	pIC50	=	9.4	9.4	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565608	179374	None	0	Human	Functional	pIC50	=	9.2	9.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	179374	None	0	Human	Functional	pIC50	=	9.2	9.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	188	3391	None	49	Human	Functional	pIC50	=	9.2	9.2	1122	2	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3391	None	49	Human	Functional	pIC50	=	9.2	9.2	1122	2	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3391	None	49	Human	Functional	pIC50	=	9.2	9.2	1122	2	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	44565850	179839	None	0	Human	Functional	pIC50	=	9.0	9.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179839	None	0	Human	Functional	pIC50	=	9.0	9.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	4366334	80440	None	5	Human	Functional	pIC50	=	8.7	8.7	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214554	80440	None	5	Human	Functional	pIC50	=	8.7	8.7	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565638	189738	None	0	Human	Functional	pIC50	=	8.7	8.7	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189738	None	0	Human	Functional	pIC50	=	8.7	8.7	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3743171	80165	None	9	Human	Functional	pIC50	=	7	7.0	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213329	80165	None	9	Human	Functional	pIC50	=	7	7.0	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	145976085	163760	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204576	163760	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	145972374	164769	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4216860	164769	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	44565828	179304	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	179304	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	127035063	136573	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	CHEMBL3736149	136573	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	127037093	136595	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736252	136595	None	0	Human	Functional	pIC50	=	5	5.0	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	118464427	138421	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	138421	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	752565	138376	None	5	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770770	138376	None	5	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	44565849	179401	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473235	179401	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565805	189743	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189743	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416247	141545	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384255	141545	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44156863	8080	None	0	Human	Functional	pIC50	=	6.9	6.9	-21	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091206	8080	None	0	Human	Functional	pIC50	=	6.9	6.9	-21	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	44565827	179303	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472415	179303	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565636	179373	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472986	179373	None	0	Human	Functional	pIC50	=	6.9	6.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	171223	None	6	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	171223	None	6	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565606	179346	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	179346	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565806	180214	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	180214	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168295984	192329	None	0	Human	Functional	pIC50	=	5.9	5.9	-8	3	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5204813	192329	None	0	Human	Functional	pIC50	=	5.9	5.9	-8	3	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	127034715	136481	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735261	136481	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035064	136558	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735911	136558	None	0	Human	Functional	pIC50	=	5.9	5.9	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	127034730	136526	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735643	136526	None	0	Human	Functional	pIC50	=	4.9	4.9	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	46830134	8219	None	0	Human	Functional	pIC50	=	6.9	6.9	-37	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1092241	8219	None	0	Human	Functional	pIC50	=	6.9	6.9	-37	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	3781561	138685	None	5	Human	Functional	pIC50	=	5.9	5.9	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL377562	138685	None	5	Human	Functional	pIC50	=	5.9	5.9	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	10449757	3495	None	34	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3495	None	34	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3495	None	34	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	71528206	87005	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323581	87005	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	3830738	141733	None	5	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL385346	141733	None	5	Human	Functional	pIC50	=	6.9	6.9	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565831	180542	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	180542	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	145988313	167331	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	167331	None	0	Human	Functional	pIC50	=	7.9	7.9	-	1	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	4203621	139075	None	12	Human	Functional	pIC50	=	5.8	5.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL378541	139075	None	12	Human	Functional	pIC50	=	5.8	5.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	3898525	139666	None	5	Human	Functional	pIC50	=	7.8	7.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL379734	139666	None	5	Human	Functional	pIC50	=	7.8	7.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565635	179372	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	179372	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565641	179424	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	CHEMBL473391	179424	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	44565829	179324	None	1	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472589	179324	None	1	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	53327611	69776	None	0	Human	Functional	pIC50	=	5.8	5.8	-154	2	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	CHEMBL1935601	69776	None	0	Human	Functional	pIC50	=	5.8	5.8	-154	2	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	44416290	141471	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL383860	141471	None	0	Human	Functional	pIC50	=	7.8	7.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	44565824	179399	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	179399	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44155109	8176	None	4	Human	Functional	pIC50	=	6.8	6.8	-21	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091919	8176	None	4	Human	Functional	pIC50	=	6.8	6.8	-21	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	732268	138383	None	26	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770837	138383	None	26	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	44565635	179372	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	179372	None	0	Human	Functional	pIC50	=	5.8	5.8	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3716424	81081	None	5	Human	Functional	pIC50	=	6.8	6.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215380	81081	None	5	Human	Functional	pIC50	=	6.8	6.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3826158	79958	None	9	Human	Functional	pIC50	=	6.8	6.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212506	79958	None	9	Human	Functional	pIC50	=	6.8	6.8	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	118464428	138348	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770512	138348	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	145988313	167331	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	167331	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	136020618	164009	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4207302	164009	None	0	Human	Functional	pIC50	=	4.8	4.8	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	3736302	139005	None	5	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL378357	139005	None	5	Human	Functional	pIC50	=	6.7	6.7	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	188	3391	None	49	Human	Functional	pIC50	=	7.7	7.7	1122	2	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3391	None	49	Human	Functional	pIC50	=	7.7	7.7	1122	2	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3391	None	49	Human	Functional	pIC50	=	7.7	7.7	1122	2	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	145979048	166753	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL4281546	166753	None	0	Human	Functional	pIC50	=	5.7	5.7	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	44565846	180674	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	180674	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	171223	None	6	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	171223	None	6	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565830	179828	None	1	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179828	None	1	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189802	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189802	None	0	Human	Functional	pIC50	=	8.6	8.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416309	141528	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384160	141528	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	145993660	167465	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4294723	167465	None	0	Human	Functional	pIC50	=	6.7	6.7	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	44565637	179396	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473187	179396	None	0	Human	Functional	pIC50	=	7.7	7.7	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	71528204	87003	None	0	Human	Functional	pIC50	=	7.7	7.7	-15	3	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323579	87003	None	0	Human	Functional	pIC50	=	7.7	7.7	-15	3	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	118464429	167213	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4290245	167213	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	26694436	163007	None	1	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4173963	163007	None	1	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	44565807	180216	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474840	180216	None	0	Human	Functional	pIC50	=	5.6	5.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416259	138290	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL376978	138290	None	0	Human	Functional	pIC50	=	7.6	7.6	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3649661	138306	None	5	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	138306	None	5	Human	Functional	pIC50	=	7.6	7.6	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	11502243	189615	None	40	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	189615	None	40	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11949710	202358	None	0	Human	Functional	pIC50	=	7.6	7.6	-50	3	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	202358	None	0	Human	Functional	pIC50	=	7.6	7.6	-50	3	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	5093797	81104	None	6	Human	Functional	pIC50	=	6.6	6.6	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215461	81104	None	6	Human	Functional	pIC50	=	6.6	6.6	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	895660	32401	None	5	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL1411080	32401	None	5	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	118464425	138396	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	138396	None	0	Human	Functional	pIC50	=	6.6	6.6	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5113614	80092	None	5	Human	Functional	pIC50	=	7.5	7.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213005	80092	None	5	Human	Functional	pIC50	=	7.5	7.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565808	181017	None	0	Human	Functional	pIC50	=	8.5	8.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	181017	None	0	Human	Functional	pIC50	=	8.5	8.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11502243	189615	None	40	Human	Functional	pIC50	=	8.5	8.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	189615	None	40	Human	Functional	pIC50	=	8.5	8.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11957541	1459	None	23	Human	Functional	pIC50	=	8.5	8.5	1	4	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	1229	1459	None	23	Human	Functional	pIC50	=	8.5	8.5	1	4	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	147	1459	None	23	Human	Functional	pIC50	=	8.5	8.5	1	4	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	170617	1459	None	23	Human	Functional	pIC50	=	8.5	8.5	1	4	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	CHEMBL6616	1459	None	23	Human	Functional	pIC50	=	8.5	8.5	1	4	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	3723094	79995	None	7	Human	Functional	pIC50	=	7.5	7.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212656	79995	None	7	Human	Functional	pIC50	=	7.5	7.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565608	179374	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	179374	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565846	180674	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	180674	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168284710	191702	None	0	Human	Functional	pIC50	=	5.5	5.5	-18	3	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5195241	191702	None	0	Human	Functional	pIC50	=	5.5	5.5	-18	3	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	136020617	57339	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL1651095	57339	None	0	Human	Functional	pIC50	=	4.5	4.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	44565805	189743	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189743	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416260	80022	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212755	80022	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565847	180675	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	180675	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565808	181017	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	181017	None	0	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11248240	2664	None	5	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	5601	2664	None	5	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	CHEMBL175543	2664	None	5	Human	Functional	pIC50	=	5.5	5.5	-	1	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	752521	201193	None	5	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	201193	None	5	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	118464420	138332	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	138332	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	44565634	179347	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472791	179347	None	0	Human	Functional	pIC50	=	6.5	6.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565850	179839	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179839	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	118464420	138332	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770342	138332	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	118464426	138333	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770351	138333	None	0	Human	Functional	pIC50	=	7.5	7.5	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	3751272	80627	None	9	Human	Functional	pIC50	=	6.5	6.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215024	80627	None	9	Human	Functional	pIC50	=	6.5	6.5	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	71528205	87004	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323580	87004	None	0	Human	Functional	pIC50	=	7.4	7.4	-	1	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	145963830	164218	None	0	Human	Functional	pIC50	=	5.4	5.4	3	2	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4209942	164218	None	0	Human	Functional	pIC50	=	5.4	5.4	3	2	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	127035065	136587	None	0	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	CHEMBL3736207	136587	None	0	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	44565606	179346	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	179346	None	0	Human	Functional	pIC50	=	8.4	8.4	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	73389570	162096	None	37	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	CHEMBL4159471	162096	None	37	Human	Functional	pIC50	=	5.4	5.4	-	1	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	2884131	167004	None	4	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286420	167004	None	4	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	44155107	8081	None	4	Human	Functional	pIC50	=	6.4	6.4	-60	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091207	8081	None	4	Human	Functional	pIC50	=	6.4	6.4	-60	2	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	4297073	81332	None	5	Human	Functional	pIC50	=	7.4	7.4	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215883	81332	None	5	Human	Functional	pIC50	=	7.4	7.4	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	46933845	16169	None	0	Human	Functional	pIC50	=	7.4	7.4	-18	2	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16169	None	0	Human	Functional	pIC50	=	7.4	7.4	-18	2	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	135753059	190827	None	2	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5182403	190827	None	2	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	135753074	191217	None	7	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5187824	191217	None	7	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	135753056	191284	None	1	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5188949	191284	None	1	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	156208582	192142	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	CHEMBL5202029	192142	None	0	Human	Functional	pIC50	=	6.4	6.4	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	3765560	141632	None	7	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384745	141632	None	7	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4518239	81088	None	5	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215404	81088	None	5	Human	Functional	pIC50	=	6.4	6.4	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	879244	28207	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL1373650	28207	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	4322819	80454	None	15	Human	Functional	pIC50	=	7.3	7.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL214594	80454	None	15	Human	Functional	pIC50	=	7.3	7.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	118464421	167388	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4293638	167388	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	44247568	82205	None	43	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	CHEMBL2170062	82205	None	43	Human	Functional	pIC50	=	5.3	5.3	-	1	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	44565806	180214	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	180214	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	170792991	196262	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Partial agonist activity at 5-HT2B receptor (unknown origin)Partial agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	351	1	1	5	3.1	Cn1ccc2cc(-n3c(=O)[nH]c4sc5c(c4c3=O)CCCC5)ccc21	10.1021/acs.jmedchem.3c01178
	CHEMBL5419983	196262	None	0	Human	Functional	pIC50	=	6.3	6.3	-	1	Partial agonist activity at 5-HT2B receptor (unknown origin)Partial agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	351	1	1	5	3.1	Cn1ccc2cc(-n3c(=O)[nH]c4sc5c(c4c3=O)CCCC5)ccc21	10.1021/acs.jmedchem.3c01178
	2267399	138428	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771373	138428	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	136928971	138316	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770185	138316	None	0	Human	Functional	pIC50	=	7.3	7.3	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5128094	79888	None	15	Human	Functional	pIC50	=	7.3	7.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212228	79888	None	15	Human	Functional	pIC50	=	7.3	7.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	5167627	80093	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213006	80093	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44416351	80166	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	CHEMBL213332	80166	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	3802375	80348	None	5	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214184	80348	None	5	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4657811	80550	None	6	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214802	80550	None	6	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	5165122	81082	None	17	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215386	81082	None	17	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	3757038	81504	None	8	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215991	81504	None	8	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	3773677	139072	None	5	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	CHEMBL378540	139072	None	5	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	3410378	141549	None	6	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384270	141549	None	6	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	4679720	166072	None	5	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	CHEMBL425260	166072	None	5	Human	Functional	pIC50	=	5.3	5.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	4148445	138388	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770873	138388	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	164937988	195320	None	4	Human	Functional	pIC50	=	6.3	6.3	-19	5	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	CHEMBL5400876	195320	None	4	Human	Functional	pIC50	=	6.3	6.3	-19	5	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium flux assay	ChEMBL	338	5	0	5	3.4	c1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1021/acs.jmedchem.3c00734
	3391669	141928	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL386459	141928	None	5	Human	Functional	pIC50	=	6.3	6.3	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	44565607	189674	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	189674	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	179400	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	179400	None	0	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565826	179302	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472414	179302	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44476436	82379	None	8	Human	Functional	pIC50	=	5.2	5.2	-7413	2	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	CHEMBL2172186	82379	None	8	Human	Functional	pIC50	=	5.2	5.2	-7413	2	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	162674022	183327	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	183327	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	127037059	136624	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736516	136624	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	10449757	3495	None	34	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3495	None	34	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3495	None	34	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	44565639	179423	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	179423	None	0	Human	Functional	pIC50	=	7.2	7.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	44565640	189614	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL513993	189614	None	0	Human	Functional	pIC50	=	5.2	5.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44138039	179395	None	8	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	179395	None	8	Human	Functional	pIC50	=	8.2	8.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189802	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189802	None	0	Human	Functional	pIC50	=	6.2	6.2	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565639	179423	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	179423	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	145989393	167319	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4292168	167319	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	3473601	140216	None	5	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL380167	140216	None	5	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44565830	179828	None	1	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179828	None	1	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	57495353	125107	None	38	Human	Functional	pIC50	=	5.1	5.1	-	1	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	CHEMBL3643413	125107	None	38	Human	Functional	pIC50	=	5.1	5.1	-	1	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	170793071	196895	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Partial agonist activity at 5-HT2B receptor (unknown origin)Partial agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	443	4	1	7	2.6	CS(=O)(=O)CCn1ccc2cc(-n3c(=O)[nH]c4sc5c(c4c3=O)CCCC5)ccc21	10.1021/acs.jmedchem.3c01178
	CHEMBL5434327	196895	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Partial agonist activity at 5-HT2B receptor (unknown origin)Partial agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	443	4	1	7	2.6	CS(=O)(=O)CCn1ccc2cc(-n3c(=O)[nH]c4sc5c(c4c3=O)CCCC5)ccc21	10.1021/acs.jmedchem.3c01178
	3400827	79944	None	8	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212457	79944	None	8	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	127035062	136538	None	0	Human	Functional	pIC50	=	6.1	6.1	6	3	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	136538	None	0	Human	Functional	pIC50	=	6.1	6.1	6	3	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035066	136508	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735434	136508	None	0	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	44565828	179304	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	179304	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	145964159	164424	None	0	Human	Functional	pIC50	=	6.1	6.1	8	2	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	164424	None	0	Human	Functional	pIC50	=	6.1	6.1	8	2	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44565638	189738	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189738	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3499360	141607	None	5	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384579	141607	None	5	Human	Functional	pIC50	=	6.1	6.1	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	104697662	145493	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	CHEMBL3914002	145493	None	0	Human	Functional	pIC50	=	6.1	6.1	-	1	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	11536299	183392	None	6	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	CHEMBL479683	183392	None	6	Human	Functional	pIC50	=	5.1	5.1	-	1	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	109052212	162642	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4168125	162642	None	0	Human	Functional	pIC50	=	7.1	7.1	-	1	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	44565607	189674	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	189674	None	0	Human	Functional	pIC50	=	6.0	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3442850	169664	None	17	Human	Functional	pIC50	=	7.0	7.0	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL443570	169664	None	17	Human	Functional	pIC50	=	7.0	7.0	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	4895014	80031	None	5	Human	Functional	pIC50	=	7.0	7.0	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212780	80031	None	5	Human	Functional	pIC50	=	7.0	7.0	-	1	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565824	179399	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	179399	None	0	Human	Functional	pIC50	=	7.0	7.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	179400	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	179400	None	0	Human	Functional	pIC50	=	6	6.0	-	1	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	12611598	60457	None	6	Rat	Functional	pKd	=	7	7.0	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60457	None	6	Rat	Functional	pKd	=	7	7.0	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	221	3491	None	49	Rat	Functional	pKd	=	8.0	8.0	-	3	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	3277600	3491	None	49	Rat	Functional	pKd	=	8.0	8.0	-	3	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	CHEMBL323356	3491	None	49	Rat	Functional	pKd	=	8.0	8.0	-	3	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	44385952	62228	None	2	Rat	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	CHEMBL177800	62228	None	2	Rat	Functional	pKd	=	7.9	7.9	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	135398737	958	None	57	Rat	Functional	pKd	=	6.9	6.9	-	43	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	135398737.0	958	None	57	Rat	Functional	pKd	=	6.9	6.9	-	43	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	38	958	None	57	Rat	Functional	pKd	=	6.9	6.9	-	43	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	722	958	None	57	Rat	Functional	pKd	=	6.9	6.9	-	43	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	CHEMBL42	958	None	57	Rat	Functional	pKd	=	6.9	6.9	-	43	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	DB00363	958	None	57	Rat	Functional	pKd	=	6.9	6.9	-	43	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	10022745	120033	None	0	Rat	Functional	pKd	=	6.9	6.9	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	CHEMBL349832	120033	None	0	Rat	Functional	pKd	=	6.9	6.9	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	44327167	9380	None	0	Rat	Functional	pKd	=	6.9	6.9	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL111393	9380	None	0	Rat	Functional	pKd	=	6.9	6.9	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL544319	9380	None	0	Rat	Functional	pKd	=	6.9	6.9	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	12611606	60398	None	7	Rat	Functional	pKd	=	6.9	6.9	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	CHEMBL174723	60398	None	7	Rat	Functional	pKd	=	6.9	6.9	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	12611609	60456	None	6	Rat	Functional	pKd	=	6.9	6.9	-	0	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	CHEMBL175204	60456	None	6	Rat	Functional	pKd	=	6.9	6.9	-	0	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	12611617	60375	None	1	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174563	60375	None	1	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	12611598	60457	None	6	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60457	None	6	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	10356829	59711	None	0	Rat	Functional	pKd	=	7.8	7.8	-	0	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	CHEMBL172269	59711	None	0	Rat	Functional	pKd	=	7.8	7.8	-	0	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	10693836	9339	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL111189	9339	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL545488	9339	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10715378	15525	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	CHEMBL121744	15525	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	9979654	210378	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL96781	210378	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611613	60480	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	CHEMBL175328	60480	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	10473483	8652	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL109528	8652	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL544318	8652	None	0	Rat	Functional	pKd	=	6.8	6.8	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	135398737	958	None	57	Rat	Functional	pKd	=	6.8	6.8	-	43	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	135398737.0	958	None	57	Rat	Functional	pKd	=	6.8	6.8	-	43	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	38	958	None	57	Rat	Functional	pKd	=	6.8	6.8	-	43	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	722	958	None	57	Rat	Functional	pKd	=	6.8	6.8	-	43	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	CHEMBL42	958	None	57	Rat	Functional	pKd	=	6.8	6.8	-	43	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	DB00363	958	None	57	Rat	Functional	pKd	=	6.8	6.8	-	43	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	10710246	121191	None	0	Rat	Functional	pKd	=	5.7	5.7	-	0	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL357517	121191	None	0	Rat	Functional	pKd	=	5.7	5.7	-	0	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34696	None	1	Rat	Functional	pKd	=	6.7	6.7	-	0	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143022	34696	None	1	Rat	Functional	pKd	=	6.7	6.7	-	0	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34696	None	1	Rat	Functional	pKd	=	6.7	6.7	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143022	34696	None	1	Rat	Functional	pKd	=	6.7	6.7	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	11760018	53381	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL160019	53381	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	44326982	8661	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL109548	8661	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL545727	8661	None	0	Rat	Functional	pKd	=	6.7	6.7	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	10090486	53288	None	0	Rat	Functional	pKd	=	6.6	6.6	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL159929	53288	None	0	Rat	Functional	pKd	=	6.6	6.6	-	0	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	10090424	34706	None	1	Rat	Functional	pKd	=	6.6	6.6	-	0	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143027	34706	None	1	Rat	Functional	pKd	=	6.6	6.6	-	0

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Main reference

Ligand source activities (1 row/activity)