GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	46780481	107504	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	107504	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	107504	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	107504	20	None	-6	15	Human	8.9	pAC50	=	8.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	3151	1450	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	945	1450	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	965	1450	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL219916	1450	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01184	1450	97	None	-1905	24	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	216239	23763	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1200485	23763	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	CHEMBL1336	23763	118	None	-5	11	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1038/s41467-023-40064-9
	2176	49615	81	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1566249	49615	81	None	-	1	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	6	1	8	2.6	CCOC(=O)OC(C)OC1=C(C(=O)Nc2ccccn2)N(C)S(=O)(=O)c2ccccc21	10.1038/s41467-023-40064-9
	72106	78163	60	None	-3	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL2105059	78163	60	None	-3	3	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	395	6	1	6	3.3	O=C(OCCN1CCOCC1)c1cccnc1Nc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	45138674	16614	50	None	-5	6	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1241951	16614	50	None	-5	6	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	572	6	1	7	5.7	COc1cccc(N2CCN(C3=Nc4c(F)cccc4[C@H](CC(=O)O)N3c3cc(C(F)(F)F)ccc3OC)CC2)c1	10.1038/s41467-023-40064-9
	439280	119993	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	6971044	119993	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL350221	119993	107	None	-25	9	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1038/s41467-023-40064-9
	432824	78235	13	None	-1	4	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	CHEMBL2106996	78235	13	None	-1	4	Human	6.0	pAC50	=	6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	273	2	0	2	3.5	CC(C)N1CCOC(c2cccc(C(F)(F)F)c2)C1	10.1038/s41467-023-40064-9
	242	469	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-33	33	Human	7.0	pAC50	=	7.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	123606	351	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	351	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	351	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	351	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	351	70	None	-199	6	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	5994	4609	88	None	-3	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	CHEMBL103	4609	88	None	-3	10	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	1	0	2	4.7	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C	10.1038/s41467-023-40064-9
	2335	11816	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	11816	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	11816	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	11816	22	None	-81	34	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	3149	12582	15	None	-30	26	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1187011	12582	15	None	-30	26	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	334	15	0	1	6.1	CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1	10.1038/s41467-023-40064-9
	56959	31526	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1404	31526	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL1526084	31526	103	None	-7	9	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	427	9	2	6	2.3	COc1ccccc1OCC(O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1	10.1038/s41467-023-40064-9
	4034	55792	55	None	-8	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55792	55	None	-8	18	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	71398	106412	44	None	-1548	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL313972	106412	44	None	-1548	14	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	5	4	4	3.6	C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1	10.1038/s41467-023-40064-9
	180	400	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-398	38	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	1890	2739	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2739	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2739	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2739	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2739	49	None	-2	24	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	3316	31730	71	None	17	4	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31730	71	None	17	4	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	4993	122331	110	None	-5	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122331	110	None	-5	5	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	441074	19382	82	None	1	11	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19382	82	None	1	11	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	3658	4076	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4076	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4076	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4076	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4076	53	None	-141	18	Human	5.9	pAC50	=	5.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	191	402	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	402	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	402	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	402	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	402	98	None	-3	36	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	1613	2333	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-5	34	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4640	78237	30	None	1	11	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2107011	78237	30	None	1	11	Human	6.9	pAC50	=	6.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	379	6	1	4	3.9	COc1cc2[nH]c(C)c(CCN3CCN(c4ccccc4)CC3)c2cc1OC	10.1038/s41467-023-40064-9
	3158	56237	27	None	-323	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-323	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	4011	82379	49	None	-75	26	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	CHEMBL21731	82379	49	None	-75	26	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1038/s41467-023-40064-9
	2520	203985	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	203985	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	203985	70	None	-1	20	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	5906	14463	23	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14463	23	None	1	4	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	72093	35031	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-2	28	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4746	204868	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1334033	204868	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL75880	204868	31	None	-10	19	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	277	4	1	1	5.3	C1CCC(C(CC2CCCCN2)C2CCCCC2)CC1	10.1038/s41467-023-40064-9
	1012	26	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1013	26	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1057	26	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	5757	26	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	CHEMBL135	26	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	DB00783	26	86	None	-7079	4	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	272	0	2	2	3.6	Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C	10.1038/s41467-023-40064-9
	1224	1420	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1420	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1420	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1420	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1420	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1420	83	None	-707	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	202	1496	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	60835	1496	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	972	1496	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1175	1496	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	DB00476	1496	77	None	-8	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	10.1038/s41467-023-40064-9
	2419	3437	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5152	3437	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	559	3437	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL1263	3437	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB00938	3437	84	None	-25703	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	415	16	4	5	4.1	OCc1cc(ccc1O)C(CNCCCCCCOCCCCc1ccccc1)O	10.1038/s41467-023-40064-9
	5077	3552	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	7552	3552	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9913767	3552	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL238804	3552	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	DB11362	3552	79	None	-457	13	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	2855	4101	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	3322	4101	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5717	4101	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	CHEMBL603	4101	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	DB00549	4101	104	None	-6025	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	575	8	2	7	5.7	COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C	10.1038/s41467-023-40064-9
	5029	15513	92	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	CHEMBL1219	15513	92	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	359	8	1	5	3.0	COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C	10.1038/s41467-023-40064-9
	2162	41484	100	None	-6	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-6	22	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	47510	172522	39	None	-7	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	CHEMBL448416	172522	39	None	-7	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	220	1	3	2	1.4	CN=C(N)NC(=O)Nc1c(C)cccc1C	10.1038/s41467-023-40064-9
	22323	15267	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	9571037	15267	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	CHEMBL1213553	15267	32	None	-6	11	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
	2895	203569	41	None	-60	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL669	203569	41	None	-60	15	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	2713	205248	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205248	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205248	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205248	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205248	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205248	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205248	82	None	-1	27	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2543	3681	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3681	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3681	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3681	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3681	68	None	-1023	14	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	443955	204347	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	CHEMBL71752	204347	92	None	-11	8	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	350	3	0	4	4.1	CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c(n1c1ccccc41)[C@@H]32	10.1038/s41467-023-40064-9
	5357	98708	41	None	-117	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL277945	98708	41	None	-117	5	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	7	1	5	1.7	CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC	10.1038/s41467-023-40064-9
	16351	102703	47	None	-208	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL304902	102703	47	None	-208	17	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	57469	18834	125	None	-10	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18834	125	None	-10	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	2286	3161	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-40	28	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2393	3309	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3309	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3309	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3309	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3309	82	None	-2511	9	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	4046	2466	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-33	17	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	104850	3305	96	None	-1230	28	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	3305	96	None	-1230	28	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	3305	96	None	-1230	28	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	3305	96	None	-1230	28	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	3305	96	None	-1230	28	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	1056	3346	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	2405	3346	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	77999	3346	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	CHEMBL121	3346	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	DB00412	3346	116	None	-25	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	7	1	6	2.5	O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C	10.1038/s41467-023-40064-9
	24776445	3966	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	4227	3966	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	6975	3966	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	CHEMBL473417	3966	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	DB08828	3966	115	None	-1778	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	420	4	1	4	4.7	O=C(c1ccc(cc1Cl)S(=O)(=O)C)Nc1ccc(c(c1)c1ccccn1)Cl	10.1038/s41467-023-40064-9
	3081361	93905	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	CHEMBL24828	93905	123	None	-22	14	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	474	5	1	5	4.4	COc1cc2/c(=N/c3ccc(Br)cc3F)nc[nH]c2cc1OCC1CCN(C)CC1	10.1038/s41467-023-40064-9
	2372	106441	40	None	-537	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL314010	106441	40	None	-537	6	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	345	10	2	5	2.6	COc1ccc(CCNCC(O)COc2cccc(C)c2)cc1OC	10.1038/s41467-023-40064-9
	71731823	111678	61	None	-11	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	CHEMBL3286830	111678	61	None	-11	3	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	0	1	7	2.8	C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)c2ccc(F)cc21	10.1038/s41467-023-40064-9
	3074	17926	26	None	-12	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL126075	17926	26	None	-12	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	604	16	0	12	3.5	COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL508338	188942	0	None	-218	15	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	2105	3032	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3032	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3032	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3032	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3032	37	None	-3	25	Human	7.8	pAC50	=	7.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	11658860	2329	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2329	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2329	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2329	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2329	51	None	-35	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	124087	1377	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-1	27	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	2165	203760	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3647519	203760	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	CHEMBL682	203760	71	None	3	8	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	355	6	2	4	5.2	CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O	10.1038/s41467-023-40064-9
	3108	207264	116	None	-7	7	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	CHEMBL932	207264	116	None	-7	7	Human	4.8	pAC50	=	4.8	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	504	12	4	12	-0.0	OCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1	10.1038/s41467-023-40064-9
	1209	1645	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1645	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1645	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1645	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1645	75	None	-56	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	260	3840	54	None	-15	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2775	3840	54	None	-15	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	656665	3840	54	None	-15	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL56564	3840	54	None	-15	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB11699	3840	54	None	-15	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	2	1	3	3.0	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)c1c[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	4497	34374	99	None	-9	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	CHEMBL1428	34374	99	None	-9	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	8	1	8	3.0	COCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
	3823	50191	42	None	-38	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	76973198	50191	42	None	-38	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL157101	50191	42	None	-38	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
	10831	116937	25	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL338667	116937	25	None	-3	6	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	3488	179112	115	None	-120	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL472	179112	115	None	-120	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	493	8	3	5	3.6	COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1	10.1038/s41467-023-40064-9
	636403	188244	22	None	-6	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL499915	188244	22	None	-6	7	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	570	5	2	5	6.8	CC1(C)[C@@H](OC(=O)CCC(=O)O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	31703	194694	63	None	-23	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL359744	194694	63	None	-23	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	CHEMBL53463	194694	63	None	-23	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	543	5	6	12	0.0	COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1	10.1038/s41467-023-40064-9
	2333	142310	97	None	-1	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	CHEMBL388590	142310	97	None	-1	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	10.1038/s41467-023-40064-9
	2169	44817	35	None	-26	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	CHEMBL152231	44817	35	None	-26	12	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	9	3	6	1.4	COc1ccccc1OCCNCC(O)c1ccc(C)c(S(N)(=O)=O)c1	10.1038/s41467-023-40064-9
	5453	203596	102	None	-36	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	CHEMBL671	203596	102	None	-36	14	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	189	3	0	1	0.2	S=P(N1CC1)(N1CC1)N1CC1	10.1038/s41467-023-40064-9
	19861	207500	50	None	-75	10	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL946	207500	50	None	-75	10	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	290	0	0	2	3.7	CN1CCC(=C2c3ccccc3CCc3cccnc32)CC1	10.1038/s41467-023-40064-9
	137	369	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2119	369	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	563	369	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	66368	369	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	CHEMBL266195	369	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	DB00866	369	52	None	-7244	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	249	8	2	3	2.2	C=CCc1ccccc1OCC(CNC(C)C)O	10.1038/s41467-023-40064-9
	2541	783	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	587	783	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	6907	783	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1016	783	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB00796	783	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	DB13919	783	120	None	-8511	10	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	7	2	7	4.0	CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O	10.1038/s41467-023-40064-9
	4942	5686	50	None	-19	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1078261	5686	50	None	-19	11	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	367	7	0	4	4.0	CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	10102	2529	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	1824	2529	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	65906	2529	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	CHEMBL94454	2529	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	DB12523	2529	88	None	-1548	4	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	432	5	1	6	3.4	Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1nccc(=O)[nH]1)C	10.1038/s41467-023-40064-9
	41684	31191	105	None	-38	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	CHEMBL1401	31191	105	None	-38	32	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	1	7	2.2	CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1	10.1038/s41467-023-40064-9
	4499	59745	99	None	-8	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL1726	59745	99	None	-8	8	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	388	6	1	7	3.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)C)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	37367	8619	14	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1095282	8619	14	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	2	0	4	3.2	CN(C)C(=O)OC1N=C(c2ccccc2)c2cc(Cl)ccc2N(C)C1=O	10.1038/s41467-023-40064-9
	11954369	189059	24	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	CHEMBL509924	189059	24	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	394	2	2	4	2.7	C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO	10.1038/s41467-023-40064-9
	5991	203896	72	None	-3	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL691	203896	72	None	-3	9	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	2	2	3.6	C#C[C@]1(O)CC[C@H]2[C@@H]3CCc4cc(O)ccc4[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	4760	204226	84	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL711	204226	84	None	-	1	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	222	1	0	2	2.8	O=C1c2ccccc2C(=O)C1c1ccccc1	10.1038/s41467-023-40064-9
	4452	2742	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2742	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2742	19	None	-107	21	Human	6.8	pAC50	=	6.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	3294	1993	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	71360	1993	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	87	1993	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	CHEMBL14376	1993	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	DB04946	1993	111	None	-1862	23	Human	5.8	pAC50	=	5.8	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
	214	3831	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-26	28	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	37	775	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	-3	12	Human	6.7	pAC50	=	6.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	57469	18834	125	None	-10	6	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1282	18834	125	None	-10	6	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	240	2	1	4	2.8	CC(C)Cn1cnc2c(N)nc3ccccc3c21	10.1038/s41467-023-40064-9
	46220502	112556	84	None	-61	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL3301610	112556	84	None	-61	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	506	7	1	8	4.9	CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1	10.1038/s41467-023-40064-9
	44112	121264	48	None	-478	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	CHEMBL357995	121264	48	None	-478	12	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	10.1038/s41467-023-40064-9
	2099	9275	55	None	52	5	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1110	9275	55	None	52	5	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	68867	78144	38	None	1	13	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78144	38	None	1	13	Human	6.7	pAC50	=	6.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	43815	186896	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186896	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186896	64	None	-125	20	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	60606	61530	73	None	1	8	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	61530	73	None	1	8	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	5591	157507	90	None	1	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	CHEMBL408	157507	90	None	1	17	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
	4046	2466	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-33	17	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	108000	56823	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	135418340	56823	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1643895	56823	39	None	-58	5	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	2	1	3	2.9	Cn1cc(C(=O)[C@@H]2CCc3[nH]cnc3C2)c2ccccc21	10.1038/s41467-023-40064-9
	445643	97360	69	None	-2	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97360	69	None	-2	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	5639	98867	75	None	-398	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	CHEMBL279229	98867	75	None	-398	13	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	387	7	1	8	0.7	COc1ccccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1	10.1038/s41467-023-40064-9
	198	312	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	82148	312	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	99	312	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	CHEMBL10878	312	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	DB06594	312	126	None	-724	4	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	2726	916	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-134	42	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2473	163159	47	None	-2454	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	CHEMBL418134	163159	47	None	-2454	4	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	248	5	2	4	1.7	CC(C)(C)NCC(O)COc1ccccc1C#N	10.1038/s41467-023-40064-9
	168871	89101	14	None	-630	13	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89101	14	None	-630	13	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	3752	27000	82	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	CHEMBL136497	27000	82	None	-	1	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	1	2	5	2.0	Nc1nc(N)nc(-c2cc(Cl)ccc2Cl)n1	10.1038/s41467-023-40064-9
	6010	30667	44	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	CHEMBL1395	30667	44	None	1	2	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	302	0	1	2	4.3	C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O	10.1038/s41467-023-40064-9
	146570	43424	67	None	-6	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1508	43424	67	None	-6	7	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCC[C@@]1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1400	1944	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1944	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1944	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1944	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1944	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1944	70	None	-4	16	Human	5.7	pAC50	=	5.7	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	4150	785	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	785	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	785	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	785	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	785	39	None	-35	15	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	2865	4112	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-23	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	4940	14438	35	None	-7	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1201210	14438	35	None	-7	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	5	0	4	4.8	CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	2202	3110	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	4850	3110	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	49	3110	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	CHEMBL1371770	3110	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	DB12478	3110	96	None	-38	10	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	10.1038/s41467-023-40064-9
	3689	102744	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1372983	102744	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL305187	102744	55	None	-331	16	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	325	5	2	3	3.8	CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	4762	14437	27	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201208	14437	27	None	-1	2	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	177	1	1	2	1.7	CC1NCCOC1c1ccccc1	10.1038/s41467-023-40064-9
	445643	97360	69	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	CHEMBL269732	97360	69	None	-2	7	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	803	7	3	12	4.6	C=CC[C@@H]1/C=C(\C)C[C@H](C)C[C@H](OC)[C@H]2O[C@@](O)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@H](/C(C)=C/[C@@H]3CC[C@@H](O)[C@H](OC)C3)[C@H](C)[C@@H](O)CC1=O)[C@H](C)C[C@@H]2OC	10.1038/s41467-023-40064-9
	53232	188601	95	None	-3548	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL503	188601	95	None	-3548	10	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	448537	160226	89	None	-28	31	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL411	160226	89	None	-28	31	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	4756	16617	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1201022	16617	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	CHEMBL1242	16617	50	None	-12	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
	27812	66961	43	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	CHEMBL1868702	66961	43	None	-2	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	308	1	1	2	3.7	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3C=C[C@@]21CC	10.1038/s41467-023-40064-9
	1153	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	1615	58	None	-28	12	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	150	2492	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2492	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2492	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2492	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2492	21	None	-2	17	Human	7.6	pAC50	=	7.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	31101	726	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-165	29	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	4046	2466	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	4252	2466	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	CHEMBL416956	2466	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	DB00358	2466	33	None	-33	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	378	2	2	3	4.4	OC(c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)C1CCCCN1	10.1038/s41467-023-40064-9
	10007	14452	38	None	1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201269	14452	38	None	1	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	54841	203104	52	None	-14	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL641	203104	52	None	-14	11	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	10.1038/s41467-023-40064-9
	1201549	594	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	594	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	594	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	594	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	594	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	594	24	None	-208	26	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	68873	43534	64	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	CHEMBL1509	43534	64	None	-2	3	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	366	0	0	3	4.3	C[C@]12CCC(=O)C=C1[C@@H]1C[C@@H]1[C@H]1[C@@H]3[C@@H]4C[C@@H]4[C@@]4(CCC(=O)O4)[C@@]3(C)CC[C@@H]12	10.1038/s41467-023-40064-9
	319	1312	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1312	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1312	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1312	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1312	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1312	44	None	-8317	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	4209	3141	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3141	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3141	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3141	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3141	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3141	75	None	-22387	17	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL508338	188942	0	None	-218	15	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	8730	195868	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	90657408	195868	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	CHEMBL559	195868	72	None	-5	5	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	777	5	3	4	4.6	N[C@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O	10.1038/s41467-023-40064-9
	4612	205957	39	None	-3	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	CHEMBL847	205957	39	None	-3	3	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	279	5	3	5	1.8	CC(C)NCC1CCc2cc(CO)c([N+](=O)[O-])cc2N1	10.1038/s41467-023-40064-9
	102	4096	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4096	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4096	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4096	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4096	48	None	-16	20	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	26987	946	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	6063	946	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	671	946	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	CHEMBL1626	946	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	DB00283	946	33	None	-263	34	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
	21722	17960	31	None	-2	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17960	31	None	-2	21	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	4450	178204	69	None	-4	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	CHEMBL465026	178204	69	None	-4	11	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	10.1038/s41467-023-40064-9
	100	3776	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	2637	3776	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	5452	3776	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	CHEMBL479	3776	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	DB00679	3776	58	None	-125	38	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1038/s41467-023-40064-9
	124	2960	47	None	-457	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2032	2960	47	None	-457	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	4636	2960	47	None	-457	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL762	2960	47	None	-457	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	DB00935	2960	47	None	-457	25	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	10.1038/s41467-023-40064-9
	2995	204382	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1696	204382	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL72	204382	53	None	-154	18	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
	2220	3112	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	3112	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	3112	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	3112	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	3112	82	None	-10	17	Human	7.6	pAC50	=	7.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	11626560	200914	94	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200914	94	None	1	14	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	213	3824	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3824	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3824	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3824	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3824	55	None	-16	22	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2402	3345	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3345	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3345	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3345	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3345	62	None	-512	17	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	10531	1408	21	None	-100	26	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-100	26	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-100	26	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-100	26	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-100	26	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2274	3151	58	None	-35	37	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4917	3151	58	None	-35	37	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	7279	3151	58	None	-35	37	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL728	3151	58	None	-35	37	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00433	3151	58	None	-35	37	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3926	207218	40	None	-4	18	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL92870	207218	40	None	-4	18	Human	5.6	pAC50	=	5.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	491	9	1	3	5.8	Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
	25271887	5128	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	5486971	5128	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	CHEMBL1059	5128	84	None	-7	2	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	159	5	2	2	1.1	CC(C)C[C@H](CN)CC(=O)O	10.1038/s41467-023-40064-9
	2351	4269	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1008	4269	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	CHEMBL1257078	4269	49	None	-12	22	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	366	10	0	3	4.8	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1	10.1038/s41467-023-40064-9
	50922675	112557	54	None	-3	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	CHEMBL3301612	112557	54	None	-3	4	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	539	9	3	9	3.9	COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1	10.1038/s41467-023-40064-9
	154257	178595	67	None	-6	19	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-6	19	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	6127	14467	8	None	-177	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL1201340	14467	8	None	-177	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	278	2	0	0	4.4	C[N+]1(C)CCC(=C(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
	5833	30453	74	None	-2	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	CHEMBL1393	30453	74	None	-2	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	416	1	0	5	4.9	CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@]34CCC(=O)O4)[C@H]12	10.1038/s41467-023-40064-9
	4413	98045	57	None	-9	15	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	CHEMBL273264	98045	57	None	-9	15	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	347	4	5	4	2.6	N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1	10.1038/s41467-023-40064-9
	5467	205905	43	None	-46	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL84158	205905	43	None	-46	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	328	8	1	5	1.2	CCN(CC)CCNC(=O)c1cc(S(C)(=O)=O)ccc1OC	10.1038/s41467-023-40064-9
	5732	206912	59	None	-138	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL911	206912	59	None	-138	4	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	307	3	0	3	3.2	Cc1ccc(-c2nc3ccc(C)cn3c2CC(=O)N(C)C)cc1	10.1038/s41467-023-40064-9
	37	775	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	-3	12	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	135	2515	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-5	33	Human	7.5	pAC50	=	7.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	168871	89101	14	None	-630	13	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	89101	14	None	-630	13	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	242	469	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-33	33	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	54477	84624	36	None	-33	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	CHEMBL22242	84624	36	None	-33	8	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	72093	35031	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-2	28	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4066	204603	78	None	-194	16	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	204603	78	None	-194	16	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	2342	596	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	331	596	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	7124	596	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	CHEMBL1201250	596	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	DB00767	596	39	None	3	8	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	404	6	0	6	2.4	CCN(C(=O)C1CN2CCc3c(C2CC1OC(=O)C)cc(c(c3)OC)OC)CC	10.1038/s41467-023-40064-9
	24826799	10766	104	None	-10	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	10766	104	None	-10	20	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	5411	204010	89	None	-11220	11	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL698	204010	89	None	-11220	11	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	135409453	3744	41	None	-28	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	-28	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	-28	36	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	1481	2053	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	3749	2053	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	589	2053	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	6908	2053	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL1513	2053	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	DB01029	2053	116	None	-38904	6	Human	4.5	pAC50	=	4.5	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	428	7	1	5	4.8	CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2	10.1038/s41467-023-40064-9
	1343	1876	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1876	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1876	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1876	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1876	62	None	-79	12	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	1440	2014	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1909	2014	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	3715	2014	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL6	2014	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB00328	2014	119	None	-93	7	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	60198	14380	83	None	-15	3	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	0	2	4.0	C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)C=CC(=O)C=C12	10.1038/s41467-023-40064-9
	CHEMBL1200374	14380	83	None	-15	3	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	296	0	0	2	4.0	C=C1C[C@@H]2[C@H](CC[C@]3(C)C(=O)CC[C@@H]23)[C@@]2(C)C=CC(=O)C=C12	10.1038/s41467-023-40064-9
	5284550	41691	15	None	-190	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1492500	41691	15	None	-190	16	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	295	3	0	2	4.7	CN(C)CC/C=C1\c2ccccc2CSc2ccccc21	10.1038/s41467-023-40064-9
	240	941	43	None	-79	23	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	2769	941	43	None	-79	23	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	44279790	941	43	None	-79	23	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	660	941	43	None	-79	23	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL1729	941	43	None	-79	23	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL560739	941	43	None	-79	23	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	DB00604	941	43	None	-79	23	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	55645	84341	8	None	-389	11	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84341	8	None	-389	11	Human	5.4	pAC50	=	5.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	4993	122331	110	None	-5	5	Human	4.4	pAC50	=	4.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL36	122331	110	None	-5	5	Human	4.4	pAC50	=	4.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	248	2	2	4	2.5	CCc1nc(N)nc(N)c1-c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	54454	5226	88	None	-1	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	5226	88	None	-1	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	4976	203556	29	None	-426	15	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL668	203556	29	None	-426	15	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	10.1038/s41467-023-40064-9
	134	2497	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2497	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2497	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2497	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2497	24	None	2	18	Human	8.4	pAC50	=	8.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	67462786	120491	56	None	2	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	CHEMBL3545376	120491	56	None	2	6	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	446	9	1	8	4.2	COc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1	10.1038/s41467-023-40064-9
	2337	3232	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-11	29	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	2407	3347	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	3347	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	3347	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	3347	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	3347	76	None	-128	17	Human	6.4	pAC50	=	6.4	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	1782	2501	84	None	-45	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	241	2501	84	None	-45	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	4168	2501	84	None	-45	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	CHEMBL86	2501	84	None	-45	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	DB01233	2501	84	None	-45	14	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	2600	3750	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-15	32	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	392622	56282	95	None	-3	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	CHEMBL163	56282	95	None	-3	20	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	10.1038/s41467-023-40064-9
	25382	9125	37	None	-117	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	9125	37	None	-117	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	441243	9804	58	None	-288	11	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	CHEMBL114	9804	58	None	-288	11	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	10.1038/s41467-023-40064-9
	3463	175122	107	None	3	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	250	6	1	2	3.6	Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1	10.1038/s41467-023-40064-9
	CHEMBL457	175122	107	None	3	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	250	6	1	2	3.6	Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1	10.1038/s41467-023-40064-9
	2389	3306	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-91	29	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	17676	7040	29	None	-1023	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	7040	29	None	-1023	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	7040	29	None	-1023	13	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	16362	3103	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-371	35	Human	4.4	pAC50	=	4.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	11561674	189587	83	None	-	1	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	460	8	1	7	2.4	CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC	10.1038/s41467-023-40064-9
	CHEMBL514800	189587	83	None	-	1	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	460	8	1	7	2.4	CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC	10.1038/s41467-023-40064-9
	135398737	955	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-8	43	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	1222	1651	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3396	1651	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	85	1651	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL46516	1651	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	DB04842	1651	49	None	-107	25	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	228	444	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	444	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	444	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	444	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	444	28	None	-575	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	19675	51640	43	None	-363	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1584	51640	43	None	-363	15	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	410	7	1	5	5.0	CC(=O)c1ccc2c(c1)N(CCCN1CCC(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	49806720	60050	99	None	1	4	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1738797	60050	99	None	1	4	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	212	3777	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-758	22	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2318	154832	29	None	3	15	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154832	29	None	3	15	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	1427	2000	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2000	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2000	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2000	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2000	54	None	-1621	30	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	165193	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	2303	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	62882	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	66366	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3165	68	None	-407	20	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	5329102	194703	86	None	-8	37	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194703	86	None	-8	37	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	2470	3626	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-30902	23	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3704	78160	41	None	3	5	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	CHEMBL2105022	78160	41	None	3	5	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	231	3	1	3	1.6	C1=Cc2cccc(OCC3CNCCO3)c2C1	10.1038/s41467-023-40064-9
	2585	800	103	None	-64	34	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	-64	34	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	-64	34	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	-64	34	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	-64	34	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	31101	726	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-165	29	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-4	33	Human	7.3	pAC50	=	7.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	2267	557	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	271	557	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	7121	557	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL639	557	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00972	557	71	None	-223	14	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
	3042	1402	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	1402	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	1402	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	1402	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	1402	35	None	-1096	17	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	4199	98817	42	None	-9	3	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL278819	98817	42	None	-9	3	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	2398	951	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2801	951	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	701	951	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL415	951	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB01242	951	62	None	-831	36	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2284	3160	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3160	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3160	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3160	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3160	33	None	-89	34	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	5803	162203	84	None	-1	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	CHEMBL41632	162203	84	None	-1	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	622	4	2	3	4.6	O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1	10.1038/s41467-023-40064-9
	1170	1620	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	3348	1620	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	4819	1620	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	74685737	1620	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL914	1620	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	DB00950	1620	75	None	-109	5	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	10	3	4	5.5	OC(=O)C(c1ccc(cc1)C(CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O)O)(C)C	10.1038/s41467-023-40064-9
	2601	3751	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	3751	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	3751	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	3751	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	3751	33	None	-186	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	25102847	78192	93	None	-4	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	78192	93	None	-4	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	3949	100586	50	None	-6	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	CHEMBL29188	100586	50	None	-6	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	468	8	0	5	4.9	COc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC	10.1038/s41467-023-40064-9
	2435	3563	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3563	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3563	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3563	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3563	83	None	-20	21	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	2136	3073	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	3073	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	3073	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	3073	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	3073	30	None	-120	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	2367	961	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	6167	961	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	726	961	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	CHEMBL107	961	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	DB01394	961	86	None	-6	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	399	5	1	6	2.9	COc1c(OC)cc2c(c1OC)c1ccc(c(=O)cc1[C@H](CC2)NC(=O)C)OC	10.1038/s41467-023-40064-9
	2247	504	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-6	42	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	3157	1458	71	None	-1318	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1458	71	None	-1318	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1458	71	None	-1318	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1458	71	None	-1318	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1458	71	None	-1318	22	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL4743867	214010	14	None	-20	15	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
	3062316	33545	121	None	-1	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33545	121	None	-1	10	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	2583	3747	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	592	3747	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	65999	3747	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	CHEMBL1017	3747	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	DB00966	3747	118	None	-3548	16	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	514	7	1	5	7.3	CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2	10.1038/s41467-023-40064-9
	103	4122	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	-6	22	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	129211	3722	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	2562	3722	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	488	3722	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	CHEMBL836	3722	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	DB00706	3722	78	None	-14125	14	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	408	11	2	6	2.3	CCOc1ccccc1OCCN[C@@H](Cc1ccc(c(c1)S(=O)(=O)N)OC)C	10.1038/s41467-023-40064-9
	16363	593	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	593	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	593	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	593	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	593	53	None	-1258	21	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	92727	204529	77	None	-1	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	628	15	4	5	4.3	Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL729	204529	77	None	-1	6	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	628	15	4	5	4.3	Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)N1CCCNC1=O	10.1038/s41467-023-40064-9
	11504295	2902	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	4814	2902	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	7543	2902	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	CHEMBL605846	2902	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	DB09080	2902	47	None	-50118	8	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	386	7	4	6	2.4	COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C	10.1038/s41467-023-40064-9
	2782	31970	67	None	-199	8	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL1407943	31970	67	None	-199	8	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	CHEMBL3216363	31970	67	None	-199	8	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	325	4	0	3	4.3	Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1	10.1038/s41467-023-40064-9
	1353	1898	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-831	39	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2771	194994	74	None	-5	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	-5	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	-5	16	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	1816	2523	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	2523	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	2523	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	2523	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	2523	102	None	-1047	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4485	69350	118	None	-42	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	CHEMBL193	69350	118	None	-42	11	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
	4567	9916	34	None	-41	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9916	34	None	-41	12	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	179	399	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	2159	399	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	963	399	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	CHEMBL243712	399	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	DB06288	399	115	None	-102	8	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1038/s41467-023-40064-9
	213046	2370	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	2370	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	2370	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	2370	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	2370	59	None	-4	17	Human	7.2	pAC50	=	7.2	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	1971	2846	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-165	32	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2448	99295	70	None	-331	15	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	CHEMBL28218	99295	70	None	-331	15	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	10.1038/s41467-023-40064-9
	1830	2572	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2572	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2572	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2572	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2572	44	None	-8	11	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	2477	742	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	36	742	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	437	742	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	CHEMBL49	742	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	DB00490	742	59	None	-104	20	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1038/s41467-023-40064-9
	5906	14463	23	None	1	4	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	CHEMBL1201319	14463	23	None	1	4	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	167	2	3	3	0.8	C[C@H](N)[C@H](O)c1cccc(O)c1	10.1038/s41467-023-40064-9
	54682461	84657	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	84657	62	None	-1	12	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	68617	205504	62	None	-14	30	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1709	205504	62	None	-14	30	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL809	205504	62	None	-14	30	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	10.1038/s41467-023-40064-9
	20628	96519	28	None	1	13	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96519	28	None	1	13	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	209	3035	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2113	3035	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	4748	3035	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL567	3035	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00850	3035	97	None	-338	14	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2540	4369	111	None	-1122	28	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1014	4369	111	None	-1122	28	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	610	10	1	11	6.3	CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	10.1038/s41467-023-40064-9
	1212	1649	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1649	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1649	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1649	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1649	50	None	-60	35	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	71496458	115538	87	None	-2	16	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	115538	87	None	-2	16	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	4418	34192	85	None	-3	18	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34192	85	None	-3	18	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	2880	97980	49	None	-8	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	CHEMBL27289	97980	49	None	-8	9	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	310	5	0	3	4.6	C=C(c1ccccc1OCc1cccc(Cl)c1)n1ccnc1	10.1038/s41467-023-40064-9
	4178	195780	63	None	3	2	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	CHEMBL558	195780	63	None	3	2	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	10.1038/s41467-023-40064-9
	1234	189197	56	None	9	10	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189197	56	None	9	10	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189197	56	None	9	10	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	6018	11033	96	None	2	3	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	CHEMBL117785	11033	96	None	2	3	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	317	4	0	4	3.2	COc1cc2c(cc1OC)C1CC(=O)C(CC(C)C)CN1CC2	10.1038/s41467-023-40064-9
	118422671	2737	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	1887	2737	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	71301	2737	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	7246	2737	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	CHEMBL434394	2737	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	DB04861	2737	65	None	-2884	23	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	405	6	3	5	2.4	OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O	10.1038/s41467-023-40064-9
	11980903	14460	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	22526	14460	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	5281035	14460	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201303	14460	19	None	-239	25	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	382	4	0	2	5.3	Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1	10.1038/s41467-023-40064-9
	138106885	166887	75	None	-4	8	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	36314	166887	75	None	-4	8	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	CHEMBL428647	166887	75	None	-4	8	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
	5282175	14400	36	None	6	4	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	CHEMBL1200661	14400	36	None	6	4	Human	6.1	pAC50	=	6.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	424	16	2	5	5.1	CCCCCCCC(=O)CC[C@@H]1[C@@H](C/C=C\CCCC(=O)OC(C)C)[C@@H](O)C[C@H]1O	10.1038/s41467-023-40064-9
	1530	2169	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2169	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2169	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2169	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2169	50	None	-3	25	Human	7.1	pAC50	=	7.1	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	5311507	194792	41	None	-10	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194792	41	None	-10	12	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	216416	111554	48	None	-19	23	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111554	48	None	-19	23	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	65700	78231	28	None	-2	8	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL2106919	78231	28	None	-2	8	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	238	1	1	2	3.3	CNC1Cc2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
	2291	3162	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	2561	3162	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	4932	3162	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL631	3162	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	DB01182	3162	58	None	-17	13	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	10.1038/s41467-023-40064-9
	5472	205795	75	None	-16	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	205795	75	None	-16	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	205795	75	None	-16	16	Human	5.0	pAC50	=	5.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2780	110502	36	None	-9	11	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110502	36	None	-9	11	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate readerAntagonist activity at human HTR2B in an in vitro cell-based assay measured by fluorescent imaging plate reader	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	43815	186896	64	None	-125	20	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186896	64	None	-125	20	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186896	64	None	-125	20	Human	5.0	pAC50	=	5	Functional	Agonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate readerAgonist activity at human HTR2B in an in vitro cell-based assay (NIBR assay) measured by fluorescent imaging plate reader	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	5	139	72	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5202	139	72	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	CHEMBL39	139	72	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	DB08839	139	72	None	-2	27	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2020.127511
	5	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5202	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	CHEMBL39	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	DB08839	139	72	None	-2	27	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	5202	139	72	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	CHEMBL39	139	72	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	DB08839	139	72	None	-2	27	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm801354e
	4376990	192985	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192985	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192985	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4376990	192985	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192985	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192985	5	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5202	139	72	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	CHEMBL39	139	72	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	DB08839	139	72	None	-2	27	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/ml200206z
	5	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	5202	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	CHEMBL39	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	DB08839	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm5019274
	439280	119993	107	None	-25	9	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	119993	107	None	-25	9	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	119993	107	None	-25	9	Human	9.0	pEC50	=	9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	5	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	5202	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	CHEMBL39	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	DB08839	139	72	None	-2	27	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2013.03.066
	439280	119993	107	None	-25	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	6971044	119993	107	None	-25	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	CHEMBL350221	119993	107	None	-25	9	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	10.1021/acs.jmedchem.5b01153
	168293874	192155	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192155	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168293874	192155	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192155	0	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	5	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5202	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	CHEMBL39	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	DB08839	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	72	None	-2	27	Human	8.8	pEC50	=	8.8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	166	3334	18	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	3045227	3334	18	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	CHEMBL76781	3334	18	None	2	4	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1021/jm0709034
	4407909	192842	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192842	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192842	1	None	1	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44315993	172853	0	None	2	3	Human	8.0	pEC50	=	8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172853	0	None	2	3	Human	8.0	pEC50	=	8	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	4407909	192842	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192842	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192842	1	None	1	3	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	16115269	138104	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	138104	0	None	-1	3	Human	7.0	pEC50	=	7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9881885	64079	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180815	64079	0	None	-19	3	Human	7.0	pEC50	=	7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63908	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	CHEMBL180668	63908	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1021/jm0709034
	10465263	64302	63	None	-89	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL181172	64302	63	None	-89	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11938	2396	7	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	146192952	2396	7	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	CHEMBL4468760	2396	7	None	-75	4	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5HT2bAgonist activity at human 5HT2b	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
	59312249	111645	0	None	-8	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286565	111645	0	None	-8	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	282	3	2	4	2.4	CNc1nc(C(C)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	122442324	138325	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138325	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138325	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11658860	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	2941	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	4374	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360328	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	DB04871	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	10379910	63271	0	None	-6	2	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179329	63271	0	None	-6	2	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.3	COc1cc2c(cc1Br)C(C(C)C)CNCC2	10.1016/j.bmcl.2004.12.080
	17954204	63908	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180668	63908	23	None	-81	3	Human	6.0	pEC50	=	6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	181	0	1	1	2.0	Clc1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2004.12.080
	122442324	138325	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138325	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138325	0	None	-12	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11493484	89041	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	89041	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	89041	0	None	-23	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	46230097	199343	0	None	-6	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	199343	0	None	-6	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	122442251	138335	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138335	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138335	0	None	-15	3	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	4312735	192850	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192850	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192850	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	4312735	192850	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5183950	192850	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221924	192850	1	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	122442251	138335	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770225	138335	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771396	138335	0	None	-15	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573155	189135	0	None	6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL511044	189135	0	None	6	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	4	2	3	1.1	O=S(=O)(NCC1CC1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	168282202	192860	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192860	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192860	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168282202	192860	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185430	192860	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221991	192860	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	44412404	77739	6	None	2	3	Human	7.0	pEC50	=	7.0	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209106	77739	6	None	2	3	Human	7.0	pEC50	=	7.0	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	206	1	1	2	1.6	Fc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	70693928	74456	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2022192	74456	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	CHEMBL2028036	74456	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	253	5	1	2	3.3	NC[C@H]1C[C@@H]1c1ccccc1OCc1ccccc1	10.1021/ml200206z
	162652937	183638	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183638	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183638	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	5	139	72	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	5202	139	72	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	CHEMBL39	139	72	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	DB08839	139	72	None	-2	27	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2009.07.063
	168	3951	15	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3951	15	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3951	15	None	3	5	Human	8.0	pEC50	=	8.0	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	157	2056	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	9840090	2056	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	CHEMBL134519	2056	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	157	2056	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	9840090	2056	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	CHEMBL134519	2056	7	None	2	3	Rat	7.9	pEC50	=	7.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1016/j.bmcl.2007.03.073
	10465263	64302	63	None	-89	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181172	64302	63	None	-89	3	Human	6.0	pEC50	=	6.0	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	162652937	183638	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4751981	183638	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802812	183638	0	None	-67	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265627	163989	0	None	-602	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	CHEMBL4208452	163989	0	None	-602	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1cccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)c1	10.1021/acsmedchemlett.8b00328
	53324327	56820	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643857	56820	0	None	-1	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)ccn1	10.1016/j.bmcl.2010.11.089
	44572176	12528	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL1186735	12528	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	CHEMBL475641	12528	0	None	-1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	2	1	1	2.8	Cc1ccc([C@H]2C[C@@H]2CN)c(Br)c1	10.1021/jm801354e
	44572207	12670	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL1187556	12670	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	CHEMBL508680	12670	0	None	-8	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	2	1	1	2.9	Cc1ccc(Cl)c([C@H]2C[C@@H]2CN)c1F	10.1021/jm801354e
	11492162	72024	3	None	-11	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197646	72024	3	None	-11	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	53317924	56821	0	None	-6	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643858	56821	0	None	-6	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	406	4	1	7	1.7	CC(=O)N(C)c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	44572180	12530	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL1186737	12530	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	CHEMBL475643	12530	1	None	2	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1ccc([C@H]2C[C@@H]2CN)cc1C	10.1021/jm801354e
	11151653	91072	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	91072	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	54587668	61429	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770378	61429	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	1355	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	142	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	CHEMBL478	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	DB12110	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.063
	44573156	187273	0	None	-2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492949	187273	0	None	-2	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	254	2	1	3	0.6	CN(C)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1355	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	142	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	CHEMBL478	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	DB12110	1998	88	None	-5	6	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.07.136
	168285159	192890	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192890	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192890	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	23652278	62601	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL178365	62601	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11608308	64279	4	None	-407	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL181076	64279	4	None	-407	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	162658803	183668	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183668	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183668	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	168285159	192890	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5196522	192890	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222172	192890	0	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162658803	183668	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759878	183668	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803107	183668	0	None	-14	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	134265732	163783	0	None	-1000	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4206126	163783	0	None	-1000	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	285	2	1	3	2.3	FC(F)(F)CCc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	134265665	164775	0	None	-1047	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4218374	164775	0	None	-1047	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	231	2	1	3	1.8	CCCc1cncc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44572751	12467	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12467	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12467	1	None	-16	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	53321948	56774	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643677	56774	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	189	3466	39	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	5163	3466	39	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	CHEMBL297784	3466	39	None	-1	4	Human	7.9	pEC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced increase in inositol1-phosphate accumulation measured after 30 mins by HTRF assay	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jmedchem.0c00424
	44431699	88260	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234837	88260	0	None	5	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	315	4	1	6	1.7	Cc1noc(Cc2c3c(c(C[C@@H](C)N)c4c2OCC4)OCC3)n1	10.1016/j.bmcl.2007.03.073
	10015414	63455	0	None	-32	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179915	63455	0	None	-32	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	259	1	1	2	3.0	COc1cc2c(cc1C(F)(F)F)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	16115271	79079	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	79079	0	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	44572168	12452	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL1186458	12452	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	CHEMBL464475	12452	1	None	-1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/jm801354e
	10036629	64607	0	None	-9	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL181787	64607	0	None	-9	3	Human	6.9	pEC50	=	6.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	23652278	62601	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178365	62601	17	None	-83	3	Human	5.9	pEC50	=	5.9	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	C[C@@H]1CNCCc2ccc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	25084025	12669	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL1187522	12669	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	CHEMBL506727	12669	1	None	-10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1cccc(Br)c1	10.1021/jm801354e
	45484687	198441	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577410	198441	0	None	-1	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	339	3	1	5	1.9	O=c1cc2c(nn1Cc1ccccc1OC(F)(F)F)CCNCC2	10.1016/j.bmcl.2009.07.063
	53323196	56819	0	None	-23	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643856	56819	0	None	-23	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1cncc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	118736623	118970	7	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425755	118970	7	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	267	3	2	3	2.4	CNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118733808	120630	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416056	120630	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546908	120630	0	None	-1	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	44573231	187270	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492911	187270	0	None	5	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc(F)cc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	216	2842	32	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	9815618	2842	32	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	CHEMBL253811	2842	32	None	1	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	10.1021/jm0709034
	162653458	183642	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183642	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183642	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	10331841	169180	6	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL440752	169180	6	None	-158	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1016/j.bmcl.2004.12.080
	44412389	78067	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210215	78067	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	162653458	183642	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4753812	183642	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802839	183642	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11447552	62498	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	CHEMBL178231	62498	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1021/jm0709034
	54585653	61435	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770385	61435	0	None	1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	307	2	1	3	2.8	FC(F)(F)c1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11427139	84658	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84658	0	None	-38	3	Human	5.8	pEC50	=	5.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53325937	56775	0	None	-53	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643678	56775	0	None	-53	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	25070581	61431	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770380	61431	0	None	-1	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	134265616	164387	0	None	-1548	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4213447	164387	0	None	-1548	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	122442286	138326	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138326	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138326	0	None	-34	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733798	120623	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416051	120623	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546894	120623	0	None	-12	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44573220	187427	0	None	4	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493951	187427	0	None	4	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	4	1	3	1.4	CN(CC1CC1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	162658689	183666	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183666	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183666	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	138323	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138323	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138323	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572371	12495	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL1186608	12495	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	CHEMBL472678	12495	0	None	-5	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1cccc(C#CCCCCO)c1	10.1021/jm801354e
	162658689	183666	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4759181	183666	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803103	183666	0	None	-28	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	122442272	138323	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138323	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138323	0	None	-54	3	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115652	83462	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83462	0	None	-15	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	54580776	61432	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770381	61432	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	118736624	118971	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425756	118971	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	4	2	3	2.8	CCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573229	172652	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	CHEMBL449999	172652	0	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1ccc2c(c1)CCNCC2)c1ccccc1F	10.1016/j.bmcl.2009.02.071
	42601405	192630	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL521805	192630	0	None	-1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	287	2	1	3	2.2	O=S(=O)(c1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	11221167	84651	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84651	0	None	-25	3	Human	6.8	pEC50	=	6.8	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	162657053	183657	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183657	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183657	0	None	-20	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	10401602	123043	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL360968	123043	0	None	-6	3	Human	6.8	pEC50	=	6.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCOc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	11447552	62498	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	CHEMBL178231	62498	4	None	-239	3	Human	5.8	pEC50	=	5.8	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2004.12.080
	25070907	61427	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770376	61427	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	44572369	12426	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186108	12426	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL450178	12426	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	171	2	1	1	1.7	C#Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	46228438	199962	0	None	-1862	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595195	199962	0	None	-1862	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1OC1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	45485742	197800	0	None	-18	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	CHEMBL572228	197800	0	None	-18	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	318	5	1	5	2.2	Clc1ccccc1CCOc1cncc(N2CCNCC2)n1	10.1016/j.bmcl.2009.07.136
	44412405	77752	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209155	77752	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	255	1	1	1	3.4	FC(F)(F)c1cccc([C@H]2CC[C@H]3CNC[C@@H]23)c1	10.1016/j.bmcl.2006.03.007
	11777150	62575	0	None	-63	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178313	62575	0	None	-63	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	0	2	2	2.4	CC1CNCCc2cc(O)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	11414184	83469	0	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83469	0	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	122442324	138325	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138325	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138325	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442324	138325	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770174	138325	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771386	138325	0	None	-12	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573216	187314	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493151	187314	0	None	4	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	268	4	2	3	1.1	CCCNS(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572759	12430	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186135	12430	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL451368	12430	1	None	-7	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	24773650	154673	2	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	CHEMBL399750	154673	2	None	-3	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)CCNCC2C	10.1021/jm0709034
	118733818	120639	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416061	120639	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546956	120639	0	None	-181	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168294162	192987	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	192987	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	192987	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	10331841	169180	6	None	-158	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	CHEMBL440752	169180	6	None	-158	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	239	0	1	1	2.7	CC1CNCCc2ccc(Br)cc21	10.1021/jm0709034
	168294162	192987	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5208129	192987	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222770	192987	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1ccc(Cl)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	135453290	133581	33	None	1	7	Rat	8.7	pEC50	=	8.7	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133581	33	None	1	7	Rat	8.7	pEC50	=	8.7	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	166	3334	18	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	3045227	3334	18	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	CHEMBL76781	3334	18	None	2	4	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmc.2007.10.100
	36906	104853	75	None	1	3	Rat	8.6	pEC50	=	8.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	CHEMBL31115	104853	75	None	1	3	Rat	8.6	pEC50	=	8.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	44572367	12511	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL1186673	12511	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	CHEMBL474230	12511	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	2	2	2.3	NC[C@H]1C[C@@H]1c1ccccc1C#CCCCCO	10.1021/jm801354e
	168291130	192952	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192952	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192952	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168291130	192952	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201835	192952	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222548	192952	0	None	2	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	11290492	137976	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL376456	137976	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	11499800	89078	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	89078	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	89078	0	None	-10	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	122442254	138320	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138320	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138320	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442254	138320	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138320	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138320	0	None	-26	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44572810	12623	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12623	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12623	2	None	-3	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	150	2492	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	1764	2492	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	8226	2492	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	CHEMBL1201356	2492	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	DB00353	2492	21	None	-2	17	Human	7.7	pEC50	=	7.7	Functional	Agonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assayAgonist at human 5HT2B receptor expressed in HEK293 cells assessed as induction of calcium influx by FLIPR assay	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	134265663	163655	0	None	-19	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4204710	163655	0	None	-19	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	243	1	1	3	2.1	c1cc(C2CCC2)c2c(n1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	53317923	56816	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643853	56816	0	None	-5	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1cccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)c1	10.1016/j.bmcl.2010.11.089
	53325936	56772	0	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643675	56772	0	None	-12	3	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	335	3	1	6	1.7	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	122442293	138317	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138317	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138317	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	122442293	138317	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3770599	138317	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	CHEMBL3771378	138317	0	None	-19	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1c(OCCF)ccc(F)c1F	10.1021/acs.jmedchem.5b01153
	11658860	2329	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2329	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2329	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2329	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2329	51	None	-35	11	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	16115381	83414	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83414	0	None	1	3	Human	7.7	pEC50	=	7.7	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	44572166	12428	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12428	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12428	0	None	-7	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	118736626	118972	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425758	118972	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	307	5	2	3	3.2	c1ccc(Cc2cc3c(c(NCC4CC4)n2)CCNCC3)cc1	10.1021/ml500507v
	18735305	204910	0	None	2	3	Human	7.7	pEC50	=	7.7	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	204910	0	None	2	3	Human	7.7	pEC50	=	7.7	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	54583742	61426	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL1770375	61426	0	None	-1	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccccc1Cc1ncc2c(n1)CCNCC2	10.1016/j.bmcl.2010.11.120
	44389645	64151	0	None	-72	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180867	64151	0	None	-72	3	Human	6.7	pEC50	=	6.7	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733790	120645	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416047	120645	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546973	120645	0	None	-36	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	44572753	12671	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187565	12671	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL509418	12671	3	None	-2	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@@H]1C[C@H]1c1ccccc1Br	10.1021/jm801354e
	53321947	56768	0	None	-2	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643671	56768	0	None	-2	3	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	257	1	1	5	1.0	c1cc2nc3c(c(N4CCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	44431701	88115	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	CHEMBL234682	88115	0	None	3	2	Rat	7.6	pEC50	=	7.6	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	311	4	1	6	3.4	Cc1noc(Cc2c3ccoc3c(C[C@@H](C)N)c3ccoc23)n1	10.1016/j.bmcl.2007.03.073
	44409290	74622	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203013	74622	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Efficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPREfficacy against human recombinant 5HT2B receptor induced intracellular calcium mobilization in CHO cells by FLIPR	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	10017556	161854	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL415029	161854	0	None	-3	3	Human	6.6	pEC50	=	6.6	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	297	2	1	2	3.5	CC(C)Oc1cc2c(cc1Br)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	118733760	120612	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416032	120612	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546869	120612	1	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11630623	89070	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	89070	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	89070	0	None	-213	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	58911653	91087	0	None	-25	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397911	91087	0	None	-25	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	168291896	192961	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192961	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192961	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	145	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	1832	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	CHEMBL7257	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	DB14010	140	49	None	-134	11	Rat	6.6	pEC50	=	6.6	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	25070911	111644	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	CHEMBL3286564	111644	0	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assayAgonist activity at recombinant human 5-HT2B receptor expressed in CHO K1 cells assessed as calcium mobilization by FLIPR assay	ChEMBL	324	3	1	5	1.6	c1ccc(Cc2nc3c(c(N4CCOCC4)n2)CCNCC3)cc1	10.1021/jm5003292
	168291564	192959	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192959	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192959	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	168291896	192961	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5201903	192961	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222595	192961	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	332	1	3	2	4.4	Oc1cc(Cl)ccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442250	138319	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138319	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138319	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	5	139	72	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	5202	139	72	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	CHEMBL39	139	72	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	DB08839	139	72	None	-2	27	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm0709034
	168291564	192959	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5201470	192959	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222574	192959	0	None	1	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	298	1	4	3	3.0	Oc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	122442250	138319	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138319	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138319	0	None	-8	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773816	94827	0	None	-31	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253805	94827	0	None	-31	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773814	94830	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253809	94830	1	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	11264345	130373	5	None	-120	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	CHEMBL368016	130373	5	None	-120	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2ccc(Cl)c(F)c21	10.1021/jm0709034
	122442300	138324	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138324	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138324	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	122442300	138324	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138324	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138324	0	None	-8	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	146025684	183611	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183611	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183611	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183639	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183639	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183639	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025684	183611	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4743977	183611	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802486	183611	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	5	1	3	2.2	C=CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162652983	183639	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4752412	183639	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802814	183639	0	None	-12	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	247	5	1	3	2.5	CCCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	45484673	198935	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL585012	198935	0	None	-8	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11595191	89031	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	89031	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	89031	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	162658153	183661	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183661	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183661	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	162658153	183661	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4758641	183661	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803076	183661	0	None	-10	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	2.5	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2c1CCO2	10.1021/acs.jmedchem.6b01194
	118736627	118973	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425759	118973	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	5	2	3	3.2	CCCNc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	118736631	118976	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	CHEMBL3425763	118976	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	238	2	1	2	2.4	c1ccc(Cc2cc3c(cn2)CCNCC3)cc1	10.1021/ml500507v
	122442270	138321	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138321	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138321	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442270	138321	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138321	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138321	1	None	-6	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11952353	199837	0	None	-1905	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	199837	0	None	-1905	3	Human	5.6	pEC50	=	5.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	11171955	91064	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397888	91064	0	None	-4	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	44573002	12654	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL1187408	12654	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	CHEMBL501854	12654	1	None	-19	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Br)cc1	10.1021/jm801354e
	16115511	84808	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84808	0	None	-6	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	162643473	183591	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183591	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183591	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	162643473	183591	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4777303	183591	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4802306	183591	0	None	-14	3	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11300712	141661	0	None	-2	3	Human	7.6	pEC50	=	7.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141661	0	None	-2	3	Human	7.6	pEC50	=	7.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44573018	12612	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL1187169	12612	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	CHEMBL492306	12612	1	None	-3	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)c(F)c1	10.1021/jm801354e
	24826869	91073	0	None	-7	3	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	91073	0	None	-7	3	Human	7.6	pEC50	=	7.6	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	16115654	136949	0	None	-46	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	136949	0	None	-46	3	Human	6.6	pEC50	=	6.6	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	53324629	56769	0	None	-4	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643672	56769	0	None	-4	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	271	1	1	5	1.4	c1cc2nc3c(c(N4CCCCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	1355	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	1355	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	1998	88	None	-5	6	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	46937339	74180	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	CHEMBL2023357	74180	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/ml200206z
	46937339	74180	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL2023357	74180	0	None	-13	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilizationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium mobilization	ChEMBL	235	5	1	2	2.7	NC[C@H]1C[C@@H]1c1cc(F)ccc1OCC1CC1	10.1021/jm5019274
	16115392	84768	0	None	-5	2	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223292	84768	0	None	-5	2	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	16115388	137341	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	137341	0	None	-2	3	Human	6.5	pEC50	=	6.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	11209786	137215	0	None	-208	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	137215	0	None	-208	3	Human	5.5	pEC50	=	5.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	9859257	205100	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	205100	0	None	1	3	Human	8.5	pEC50	=	8.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	168268877	189946	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189946	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	168268877	189946	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189946	0	None	2	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	230	4088	25	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	3045225	4088	25	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	CHEMBL407909	4088	25	None	-3	3	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.10.100
	5	139	72	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	5202	139	72	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	CHEMBL39	139	72	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	DB08839	139	72	None	-7	27	Rat	8.5	pEC50	=	8.5	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	44572798	12618	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL1187187	12618	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	CHEMBL492926	12618	2	None	-1	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1cccc(F)c1	10.1021/jm801354e
	46933845	16130	0	None	-18	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16130	0	None	-18	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor assessed as 5HT-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	54583743	61433	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770382	61433	0	None	5	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	118736630	118975	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425762	118975	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	281	3	1	3	2.4	CN(C)c1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	122442263	138332	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138332	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138332	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44389646	64853	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL182184	64853	0	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	269	1	1	2	2.7	COc1cc2c(cc1Br)[C@H](C)CNCC2	10.1016/j.bmcl.2004.12.080
	122442263	138332	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138332	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138332	0	None	-30	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442260	138329	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138329	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138329	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11949712	202138	0	None	-3019	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL609306	202138	0	None	-3019	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	118733764	120619	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416034	120619	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546890	120619	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	118733776	120625	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416040	120625	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546903	120625	0	None	-2	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	70687695	74449	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022186	74449	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027987	74449	0	None	-12	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	205	5	1	2	2.5	CCCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	134265675	164343	0	None	-40	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4212834	164343	0	None	-40	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	297	2	1	3	2.5	Fc1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162645074	183600	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183600	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183600	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	162645074	183600	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4740346	183600	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802388	183600	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	259	5	1	3	3.5	CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11400855	12422	7	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186092	12422	7	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL449134	12422	7	None	-3	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@@H]1C[C@H]1c1ccccc1	10.1021/jm801354e
	57799306	89080	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	89080	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	89080	0	None	-12	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	122442260	138329	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769543	138329	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771390	138329	0	None	-2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44315697	205482	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	205482	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	168268736	192765	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192765	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192765	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	9990808	122746	0	None	-51	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	CHEMBL360492	122746	0	None	-51	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1021/jm0709034
	168268736	192765	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5177718	192765	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221369	192765	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	296	1	3	2	3.6	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	11652452	89097	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	89097	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	89097	0	None	-9	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	44572749	12405	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL1185954	12405	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	CHEMBL443128	12405	1	None	-6	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccccc1Cl	10.1021/jm801354e
	44412150	77704	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL208936	77704	0	None	-1	3	Human	6.5	pEC50	=	6.5	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CCC3CNCC32)n1	10.1016/j.bmcl.2006.03.007
	11658860	2329	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2329	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2329	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2329	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2329	51	None	-35	11	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	122442250	138319	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138319	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138319	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	16115644	136935	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	136935	0	None	-1	3	Human	7.5	pEC50	=	7.5	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	118736628	118974	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	CHEMBL3425760	118974	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assayAgonist activity at human recombinant 5-HT2B receptor expressed in CHOK1 cells assessed as induction of Ca2+ mobilization after 1 hr by FLIPR assay	ChEMBL	295	4	2	3	3.2	CC(C)Nc1nc(Cc2ccccc2)cc2c1CCNCC2	10.1021/ml500507v
	44573230	187269	0	None	-3	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492910	187269	0	None	-3	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	305	2	1	3	2.3	O=S(=O)(c1cccc(F)c1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	3356430	193022	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193022	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193022	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	70683433	74429	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2022185	74429	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	CHEMBL2027895	74429	1	None	-18	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux measured every sec for 3 mins by FLIPR assay	ChEMBL	191	4	1	2	2.1	CCOc1ccccc1[C@H]1C[C@@H]1CN	10.1021/ml200206z
	122442250	138319	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770689	138319	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771380	138319	0	None	-8	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1cc(F)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138318	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138318	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138318	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138318	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138318	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138318	0	None	-51	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573016	12638	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL1187322	12638	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	CHEMBL498863	12638	1	None	-38	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1c(F)cccc1F	10.1021/jm801354e
	168272608	192769	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192769	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192769	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162657053	183657	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4757214	183657	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803017	183657	0	None	-20	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@H]1C[C@@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	168272608	192769	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5177484	192769	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5221391	192769	0	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	3356430	193022	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5208864	193022	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222941	193022	2	None	2	3	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	44573222	174288	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL455039	174288	0	None	2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	294	2	1	3	1.5	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCCC1	10.1016/j.bmcl.2009.02.071
	118733766	120613	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416035	120613	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546870	120613	0	None	-33	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	3.2	CCCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	146025686	183735	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183735	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183735	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	146025686	183735	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4790992	183735	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803813	183735	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	243	5	1	3	3.1	C=CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	44572757	12617	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL1187186	12617	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	CHEMBL492917	12617	1	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1ccccc1C(F)(F)F	10.1021/jm801354e
	45484742	198495	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	CHEMBL577903	198495	0	None	-1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	243	3	2	3	1.7	c1ccc(COc2n[nH]c3c2CCNCC3)cc1	10.1016/j.bmcl.2009.07.063
	122442286	138326	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138326	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138326	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	138326	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138326	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138326	0	None	-34	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44573221	193056	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	CHEMBL522514	193056	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	280	2	1	3	1.2	O=S(=O)(c1ccc2c(c1)CCNCC2)N1CCCC1	10.1016/j.bmcl.2009.02.071
	44622848	193323	0	None	-11	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL524778	193323	0	None	-11	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	255	2	1	4	1.0	O=c1cc2c(nn1Cc1ccccc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	9881119	205450	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	205450	0	None	-1	3	Human	7.4	pEC50	=	7.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	9990808	122746	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL360492	122746	0	None	-51	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	213	0	1	1	2.7	CC1CNCCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	44573012	12611	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL1187168	12611	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	CHEMBL492305	12611	0	None	-3	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1cccc(F)c1F	10.1021/jm801354e
	11206703	91063	0	None	-12	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	91063	0	None	-12	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	44572657	12435	6	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL1186169	12435	6	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	CHEMBL452719	12435	6	None	-7	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NC[C@H]1C[C@@H]1c1ccccc1	10.1021/jm801354e
	44573004	12488	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL1186590	12488	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	CHEMBL471202	12488	1	None	3	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccc([C@H]2C[C@@H]2CN)cc1	10.1021/jm801354e
	53325938	56776	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643679	56776	0	None	-4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	10105208	62469	0	None	-83	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178124	62469	0	None	-83	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1016/j.bmcl.2004.12.080
	1355	1998	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	142	1998	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	CHEMBL478	1998	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	DB12110	1998	88	None	-5	6	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0709034
	24773649	94798	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL253591	94798	0	None	-10	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	C[C@H]1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	24773651	154833	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	CHEMBL400600	154833	0	None	-6	3	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@H](C)CNCC2	10.1021/jm0709034
	46228437	199961	1	None	-39	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595194	199961	1	None	-39	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	24773895	94828	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL253806	94828	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)[C@@H](C)CNCC2	10.1021/jm0709034
	122442270	138321	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138321	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138321	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	24773979	130143	21	None	-12	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	CHEMBL367796	130143	21	None	-12	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	161	0	1	1	1.9	CC1CNCCc2ccccc21	10.1021/jm0709034
	11264955	204938	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	204938	0	None	1	3	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	152	363	29	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	2107	363	29	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	CHEMBL275854	363	29	None	-2	5	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	11708275	72683	3	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	CHEMBL199775	72683	3	None	1	2	Rat	8.4	pEC50	=	8.4	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	166	3334	18	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3334	18	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3334	18	None	2	4	Human	8.4	pEC50	=	8.4	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	5	139	72	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	5202	139	72	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	CHEMBL39	139	72	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	DB08839	139	72	None	-2	27	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF methodAgonist activity at human 5-HT2BR expressed in CHO cells assessed as induction of IP1 accumulation after 30 mins by HTRF method	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2018.01.002
	16047544	12616	8	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12616	8	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12616	8	None	-3	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	44572172	12514	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL1186686	12514	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	CHEMBL474633	12514	0	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	179	2	1	1	2.2	Cc1cc([C@H]2C[C@@H]2CN)ccc1F	10.1021/jm801354e
	16115267	84764	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84764	0	None	-2	3	Human	7.4	pEC50	=	7.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	9994008	166125	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL426235	166125	0	None	-3	3	Human	7.4	pEC50	=	7.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	283	2	1	2	3.1	CCC1CNCCc2cc(OC)c(Br)cc21	10.1016/j.bmcl.2004.12.080
	122442270	138321	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770753	138321	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771382	138321	1	None	-6	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	22368315	63736	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL180166	63736	0	None	-50	3	Human	6.4	pEC50	=	6.4	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	255	1	1	2	2.1	COc1cc2c(cc1Br)CCNCC2	10.1016/j.bmcl.2004.12.080
	134265618	164031	0	None	-323	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4209052	164031	0	None	-323	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	257	2	1	3	2.1	c1cc(CC2CCC2)c2c(n1)N1CCNCC1CC2	10.1021/acsmedchemlett.8b00328
	46884138	8411	0	None	-812	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1093699	8411	0	None	-812	3	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at 5HT2B receptorAgonist activity at 5HT2B receptor	ChEMBL	364	7	2	4	3.2	COc1cc(OCC2CCCCC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	44572812	12482	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL1186561	12482	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	CHEMBL469729	12482	1	None	-5	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1	10.1021/jm801354e
	54587669	61430	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770379	61430	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	253	2	1	3	2.1	Cc1cccc(Cc2ncc3c(n2)CCNCC3)c1	10.1016/j.bmcl.2010.11.120
	11609026	89098	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	89098	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	89098	0	None	-125	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	44573014	12489	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL1186595	12489	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	CHEMBL471802	12489	1	None	-10	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	183	2	1	1	2.0	NC[C@H]1C[C@@H]1c1ccc(F)cc1F	10.1021/jm801354e
	3568128	192909	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192909	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192909	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	3568128	192909	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5195443	192909	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222291	192909	1	None	4	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	342	3	2	3	4.1	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	44420682	137583	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137583	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	118733802	120627	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416053	120627	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546905	120627	0	None	-1	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	168284548	192887	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	192887	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	192887	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	168284548	192887	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5191889	192887	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222143	192887	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	312	1	3	2	4.1	Cc1ccc(O)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)c1	10.1021/acsmedchemlett.1c00694
	118733788	120638	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416046	120638	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546955	120638	0	None	-5	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	237	5	1	2	3.0	C=CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11658860	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183693	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183693	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183693	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	11658860	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	2941	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	4374	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	CHEMBL360328	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	DB04871	2329	51	None	-35	11	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.6b01194
	146025689	183693	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4781163	183693	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803350	183693	0	None	-17	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	271	6	1	3	3.6	C=CCOc1ccc2oc(CC)cc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733792	120646	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416048	120646	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546974	120646	0	None	-12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	162659286	183671	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183671	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183671	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	122442266	138318	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138318	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138318	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442266	138318	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769499	138318	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771379	138318	0	None	-51	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	5	1	2	2.6	C=CCOc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162659286	183671	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4762225	183671	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803142	183671	0	None	-13	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@@H]1C[C@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	146025687	183691	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183691	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183691	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	118733804	120628	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416054	120628	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546906	120628	0	None	-4	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	162668367	183715	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183715	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183715	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442309	138322	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138322	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138322	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	168294156	192981	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	192981	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	192981	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	162668367	183715	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4786831	183715	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803642	183715	0	None	-21	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.3	CC(C)Oc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	168294156	192981	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5207023	192981	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222736	192981	0	None	1	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1ccc(Br)cc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	122442254	138320	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138320	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138320	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442309	138322	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769828	138322	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771383	138322	0	None	-6	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	5	1	2	2.4	NCC1CC1c1cc(F)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572164	12651	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL1187390	12651	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	CHEMBL501526	12651	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1F	10.1021/jm801354e
	146025687	183691	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4779260	183691	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4803306	183691	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	249	5	1	3	2.8	NC[C@H]1C[C@@H]1c1c(OCCF)ccc2occc12	10.1021/acs.jmedchem.6b01194
	46230099	199289	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	199289	0	None	-25	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	118733794	120647	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416049	120647	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546975	120647	0	None	-72	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	235	4	1	2	2.4	C#CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	122442254	138320	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3770963	138320	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771381	138320	0	None	-26	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	213	3	1	2	2.0	COc1ccc(F)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442286	138326	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769987	138326	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771387	138326	0	None	-34	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	229	3	1	2	2.6	COc1ccc(Cl)c(F)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	45484682	198348	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL576651	198348	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	323	2	1	4	2.0	O=c1cc2c(nn1Cc1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11658860	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	44573153	187173	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492348	187173	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	336	3	2	3	2.8	O=S(=O)(Nc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44573157	187274	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492950	187274	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	316	3	1	3	2.2	CN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	134265622	164729	0	None	-81	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4217787	164729	0	None	-81	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	259	1	1	3	2.4	CC(C)(C)Cc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	44412388	78156	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210484	78156	0	None	-1	3	Human	7.3	pEC50	=	7.3	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	272	1	1	4	1.7	C[C@@H]1C[C@H]2CNC[C@H]2N1c1nccc(C(F)(F)F)n1	10.1016/j.bmcl.2006.03.007
	145966293	164430	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4213971	164430	0	None	-14	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	267	0	1	3	1.6	Brc1ccnc2c1CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	18735309	205410	0	None	2	3	Human	7.3	pEC50	=	7.3	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	205410	0	None	2	3	Human	7.3	pEC50	=	7.3	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	118733814	120632	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416059	120632	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546910	120632	0	None	-23	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	44572761	12648	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL1187377	12648	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	CHEMBL501117	12648	0	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1ccccc1O	10.1021/jm801354e
	11302765	84219	4	None	-309	3	Human	5.3	pEC50	=	5.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	84219	4	None	-309	3	Human	5.3	pEC50	=	5.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11448649	83404	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83404	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	50878551	90716	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90716	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	50878551	90716	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90716	61	None	1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	44572808	12674	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL1187585	12674	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	CHEMBL510383	12674	0	None	-1	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	163	2	2	2	1.5	NC[C@H]1C[C@@H]1c1cccc(O)c1	10.1021/jm801354e
	44431688	152716	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL397321	152716	0	None	1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	307	7	1	5	1.6	COCCOCc1c2c(c(C[C@@H](C)N)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	5	139	72	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	5202	139	72	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	CHEMBL39	139	72	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	DB08839	139	72	None	-2	27	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmc.2007.10.100
	135509961	136107	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	CHEMBL373245	136107	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	9991444	62602	1	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	CHEMBL178366	62602	1	None	-15	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1021/jm0709034
	154699445	177402	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	177402	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	11737032	84987	0	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	84987	0	None	-13	3	Human	6.3	pEC50	=	6.3	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	162674022	183197	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	183197	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assayAgonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	22292784	64564	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	CHEMBL181672	64564	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1021/jm0709034
	24773809	94853	0	None	-63	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254009	94853	0	None	-63	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	122442300	138324	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138324	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138324	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	24773900	123406	8	None	-6	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	CHEMBL361742	123406	8	None	-6	3	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1021/jm0709034
	118733778	120634	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3416041	120634	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	CHEMBL3546951	120634	0	None	-19	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.2	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC1CC1	10.1021/jm5019274
	50942111	56817	0	None	-5	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643854	56817	0	None	-5	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	365	4	1	7	1.7	COc1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)cc1	10.1016/j.bmcl.2010.11.089
	45485725	197804	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	CHEMBL572252	197804	0	None	-19	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in Swiss mouse 3T3 cells assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	348	5	1	6	1.9	C[C@@H](COc1ccccc1Cl)n1nc(N2CCNCC2)ccc1=O	10.1016/j.bmcl.2009.07.136
	122442300	138324	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3769421	138324	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	CHEMBL3771385	138324	0	None	-8	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1cc(Cl)c(F)cc1OCCF	10.1021/acs.jmedchem.5b01153
	44572698	12520	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL1186700	12520	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	CHEMBL474885	12520	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	197	2	1	1	2.9	NC[C@H]1C[C@@H]1c1ccc2ccccc2c1	10.1021/jm801354e
	162652562	183633	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183633	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183633	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	11658860	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	2941	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	4374	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	CHEMBL360328	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	DB04871	2329	51	None	-35	11	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/acs.jmedchem.5b01153
	11666237	89083	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	89083	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	89083	0	None	-30	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	162652562	183633	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4752604	183633	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	CHEMBL4802785	183633	0	None	-4	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.3	NC[C@@H]1C[C@H]1c1c(OCC2CC2)ccc2occc12	10.1021/acs.jmedchem.6b01194
	44572755	12427	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186115	12427	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL450599	12427	1	None	-2	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1ccccc1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	22292784	64564	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	CHEMBL181672	64564	15	None	-17	3	Human	6.3	pEC50	=	6.3	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	195	0	1	1	2.6	CC1CNCCc2cc(Cl)ccc21	10.1016/j.bmcl.2004.12.080
	118733780	120614	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416042	120614	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546871	120614	0	None	-7	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	6	1	3	2.4	COCCOc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	3572096	192874	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192874	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192874	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	3572096	192874	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5186011	192874	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222066	192874	1	None	-3	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	294	1	2	1	4.2	Cc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	162670523	183726	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183726	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183726	0	None	-20	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	146025688	183670	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183670	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183670	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	146025688	183670	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4761064	183670	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4803134	183670	0	None	-20	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	277	6	1	3	3.4	CCc1cc2c([C@H]3C[C@@H]3CN)c(OCCF)ccc2o1	10.1021/acs.jmedchem.6b01194
	11313985	91054	0	None	-18	3	Human	7.3	pEC50	=	7.3	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	91054	0	None	-18	3	Human	7.3	pEC50	=	7.3	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	11949710	199879	0	None	-50	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	199879	0	None	-50	3	Human	6.3	pEC50	=	6.3	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	118733772	120622	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416038	120622	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546893	120622	0	None	-2	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	11737939	84198	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL220900	84198	0	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	11291	3196	26	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	4980	3196	26	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	CHEMBL65547	3196	26	None	1	4	Human	7.2	pEC50	=	7.2	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1016/j.bmcl.2005.06.104
	162670523	183726	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4790652	183726	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803766	183726	0	None	-20	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	168283046	192868	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192868	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192868	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	162676809	183768	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183768	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183768	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	192910	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192910	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192910	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	162676809	183768	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4799299	183768	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4804137	183768	0	None	-5	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	261	5	1	3	3.4	C=C(F)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	4240627	192910	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5198376	192910	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222297	192910	1	None	2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)c1	10.1021/acsmedchemlett.1c00694
	44431689	87220	0	None	-13	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL232995	87220	0	None	-13	2	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	383	7	1	6	2.6	C[C@@H](N)Cc1c2c(c(COCC(=O)Oc3ccccc3)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	44572800	12621	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL1187194	12621	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	CHEMBL493128	12621	3	None	-5	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	181	2	1	1	2.4	NC[C@H]1C[C@@H]1c1cccc(Cl)c1	10.1021/jm801354e
	168283046	192868	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5185474	192868	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222039	192868	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	360	1	3	2	4.0	Oc1cc(Br)ccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	44412403	77769	0	None	7	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209254	77769	0	None	7	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	222	1	1	2	2.1	Clc1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	135399866	72026	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	CHEMBL197653	72026	2	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	44431705	145101	0	None	6	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	CHEMBL391196	145101	0	None	6	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HTAgonist activity at 5HT2B receptor in rat stomach fundus assessed as intracellular calcium mobilization relative to 5HT	ChEMBL	313	2	2	4	1.7	C[C@@H](N)[C@H](O)c1c2c(c(Br)c3c1OCC3)OCC2	10.1016/j.bmcl.2007.03.073
	18735313	204911	1	None	6	3	Human	8.2	pEC50	=	8.2	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	204911	1	None	6	3	Human	8.2	pEC50	=	8.2	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	162650400	183625	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183625	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183625	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	54581791	61434	0	None	3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770383	61434	0	None	3	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	273	2	1	3	2.4	Clc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	162650400	183625	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4748110	183625	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	CHEMBL4802669	183625	0	None	-22	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	245	4	1	3	3.1	CCc1cc2c([C@H]3C[C@@H]3CN)c(OC)ccc2o1	10.1021/acs.jmedchem.6b01194
	53324165	56771	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643674	56771	0	None	-9	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	231	2	2	5	0.8	CCNc1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	122442263	138332	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138332	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138332	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	122442263	138332	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769454	138332	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771393	138332	0	None	-30	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	245	3	1	2	3.1	COc1ccc(Cl)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	118733800	120626	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416052	120626	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546904	120626	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	251	5	1	2	3.4	C=C(C)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	46230098	199306	0	None	-30	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	199306	0	None	-30	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in HEK293E cells by FLIPR assay	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	134265705	164067	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	CHEMBL4209572	164067	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cnc2c(c1)CC[C@@H]1CNCCN21	10.1021/acsmedchemlett.8b00328
	54584721	61428	0	None	-1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	CHEMBL1770377	61428	0	None	-1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assayAgonist activity at human 5HT2B receptor expressed in CHO-K1 cells assessed as increase of fluorescence based calcium mobilization by FLIPR assay	ChEMBL	257	2	1	3	1.9	Fc1ccc(Cc2ncc3c(n2)CCNCC3)cc1	10.1016/j.bmcl.2010.11.120
	118733812	120616	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3416058	120616	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	CHEMBL3546873	120616	0	None	-4	2	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	257	6	1	2	3.1	NC[C@@H]1C[C@H]1c1cc(Cl)ccc1OCCCF	10.1021/jm5019274
	24849050	78271	2	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	CHEMBL210802	78271	2	None	-2	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	258	1	1	4	1.3	FC(F)(F)c1ccnc(N2CC[C@H]3CNC[C@H]32)n1	10.1016/j.bmcl.2006.03.007
	10036629	64607	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	CHEMBL181787	64607	0	None	-9	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	225	1	1	2	2.6	COc1cc2c(cc1Cl)C(C)CNCC2	10.1021/jm0709034
	24773728	94831	0	None	-31	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	CHEMBL253810	94831	0	None	-31	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	209	1	1	1	3.0	CC[C@@H]1CNCCc2ccc(Cl)cc21	10.1021/jm0709034
	118733806	120629	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3416055	120629	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	CHEMBL3546907	120629	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	243	5	1	2	2.8	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCCF	10.1021/jm5019274
	10064386	63287	4	None	-32	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL179378	63287	4	None	-32	3	Human	7.2	pEC50	=	7.2	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	317	1	1	2	2.5	COc1cc2c(cc1I)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	44572802	12412	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12412	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12412	2	None	-13	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	11983273	77967	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	CHEMBL209714	77967	0	None	1	3	Human	7.2	pEC50	=	7.2	Functional	Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsInduction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cells	ChEMBL	256	1	1	2	2.5	FC(F)(F)c1cccc(N2CC[C@H]3CNC[C@H]32)c1	10.1016/j.bmcl.2006.03.007
	118733796	120615	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416050	120615	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546872	120615	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.3	C=C(F)COc1ccc(Cl)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	44572747	12673	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL1187580	12673	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	CHEMBL510308	12673	2	None	-2	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccccc1F	10.1021/jm801354e
	44573217	187315	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL493152	187315	0	None	10	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	302	3	2	3	2.2	O=S(=O)(Nc1ccccc1)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	44572174	12515	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL1186687	12515	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	CHEMBL474634	12515	0	None	-2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	195	2	1	1	2.7	Cc1cccc(Cl)c1[C@H]1C[C@@H]1CN	10.1021/jm801354e
	44316017	205429	0	None	4	3	Human	8.1	pEC50	=	8.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	205429	0	None	4	3	Human	8.1	pEC50	=	8.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	11644842	89068	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337105	89068	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365394	89068	0	None	-12	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	53321865	56818	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643855	56818	0	None	-19	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	336	3	1	7	1.1	c1ccc(OC2CN(c3c4c(nc5ccnn35)CCNCC4)C2)nc1	10.1016/j.bmcl.2010.11.089
	122442273	138331	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138331	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138331	0	None	-5	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	44316027	205499	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	205499	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Functional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate readerFunctional activity against human 5-hydroxytryptamine 2B receptor expressed in CHO cells using fluorometric imaging plate reader	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	162644827	183599	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183599	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183599	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	162660358	183680	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183680	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183680	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	122442273	138331	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771152	138331	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771392	138331	0	None	-5	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	271	5	1	2	3.6	C=CCOc1cc(Cl)c(Cl)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	162644827	183599	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4739937	183599	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4802378	183599	0	None	-109	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	217	3	1	3	2.5	COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	53317925	56822	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643859	56822	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	390	3	2	7	1.2	O=C1Cc2cc(OC3CN(c4c5c(nc6ccnn46)CCNCC5)C3)ccc2N1	10.1016/j.bmcl.2010.11.089
	162660358	183680	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4762722	183680	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803207	183680	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	257	5	1	3	3.5	C=C(C)COc1ccc2occc2c1[C@@H]1C[C@H]1CN	10.1021/acs.jmedchem.6b01194
	118733816	120633	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3416060	120633	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	CHEMBL3546911	120633	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	223	5	1	2	2.7	CCCOc1ccc(F)cc1[C@@H]1C[C@H]1CN	10.1021/jm5019274
	10624	70271	19	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	138543650	70271	19	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194378	70271	19	None	6	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assayEffective concentration required for accumulation of [3H]inositol phosphate in cells transiently expressing human 5-hydroxytryptamine 2B receptor determined by phosphoinositide hydrolysis assay	ChEMBL	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	46228422	200013	0	None	-33	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL595553	200013	0	None	-33	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	329	3	1	4	3.2	Clc1ccccc1O[C@@H]1CCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44572806	12622	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1187195	12622	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL493129	12622	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	177	3	1	2	1.8	COc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	44573218	193033	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL522349	193033	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	320	3	2	3	2.3	O=S(=O)(Nc1ccccc1F)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	1534	103013	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103013	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103013	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	1534	103013	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	9287	103013	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	CHEMBL30713	103013	53	None	-3	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as increase in calcium mobilization by FLIPR assay	ChEMBL	174	2	2	1	2.1	CC(N)Cc1c[nH]c2ccccc12	10.1016/j.bmcl.2013.03.066
	162659049	183669	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183669	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183669	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265620	164382	0	None	-6456	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	CHEMBL4213379	164382	0	None	-6456	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	279	2	1	3	2.4	c1ccc(Cc2ccnc3c2CC[C@@H]2CNCCN32)cc1	10.1021/acsmedchemlett.8b00328
	162659049	183669	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4761526	183669	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803123	183669	0	None	-8	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	219	3	1	3	1.7	COc1ccc2c(c1[C@H]1C[C@@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	44572804	12591	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL1187088	12591	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	CHEMBL490064	12591	1	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	2.8	NC[C@H]1C[C@@H]1c1cccc(C(F)(F)F)c1	10.1021/jm801354e
	162669436	183721	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183721	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183721	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	134265590	164734	0	None	-2	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	CHEMBL4217846	164734	0	None	-2	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting methodAgonist activity at recombinant 5-HT2B receptor (unknown origin) expressed in HEK293 cells assessed as increase in [3H]-inositol phosphate accumulation by scintillation counting method	ChEMBL	189	0	1	3	0.8	c1cc2c(cn1)N1CCNC[C@H]1CC2	10.1021/acsmedchemlett.8b00328
	9991444	62602	1	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL178366	62602	1	None	-15	3	Human	7.1	pEC50	=	7.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2cc(Cl)c(Cl)cc21	10.1016/j.bmcl.2004.12.080
	24773900	123406	8	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	CHEMBL361742	123406	8	None	-6	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	191	1	1	2	1.9	COc1ccc2c(c1)C(C)CNCC2	10.1016/j.bmcl.2004.12.080
	162669436	183721	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4789310	183721	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	CHEMBL4803705	183721	0	None	-19	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	233	4	1	3	2.1	CCOc1ccc2c(c1[C@@H]1C[C@H]1CN)CCO2	10.1021/acs.jmedchem.6b01194
	11658860	2329	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	2941	2329	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	4374	2329	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	CHEMBL360328	2329	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	DB04871	2329	51	None	-35	11	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm0709034
	10105208	62469	0	None	-83	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL178124	62469	0	None	-83	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	CC1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	11160564	63274	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	CHEMBL179337	63274	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1021/jm0709034
	23395431	94884	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	CHEMBL254215	94884	0	None	-79	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulation	ChEMBL	229	0	1	1	3.0	C[C@@H]1CNCCc2ccc(C(F)(F)F)cc21	10.1021/jm0709034
	16115517	84809	0	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84809	0	None	-5	3	Human	8.1	pEC50	=	8.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44572178	12529	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL1186736	12529	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	CHEMBL475642	12529	0	None	-1	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	175	2	1	1	2.4	Cc1cccc([C@H]2C[C@@H]2CN)c1C	10.1021/jm801354e
	135520431	72580	9	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL199385	72580	9	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	135414348	72780	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL200104	72780	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	44573154	187174	0	None	-17	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	CHEMBL492349	187174	0	None	-17	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor by cell-based systemAgonist activity at human recombinant 5HT2B receptor by cell-based system	ChEMBL	350	4	2	3	2.5	O=S(=O)(NCc1ccccc1Cl)c1ccc2c(c1)CCNCC2	10.1016/j.bmcl.2009.02.071
	45484662	198468	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL577691	198468	0	None	-2	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1cccc(Cl)c1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11231392	84865	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84865	0	None	-7	3	Human	6.1	pEC50	=	6.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	71682217	91089	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397913	91089	0	None	-10	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44572170	12433	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL1186164	12433	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	CHEMBL452458	12433	1	None	-4	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	215	2	1	1	3.1	NC[C@H]1C[C@@H]1c1ccc(Cl)cc1Cl	10.1021/jm801354e
	118733810	120631	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3416057	120631	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	CHEMBL3546909	120631	0	None	-9	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	3.0	NC[C@H]1C[C@@H]1c1cc(Cl)ccc1OCC(F)F	10.1021/jm5019274
	162657367	183658	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183658	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183658	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	45484700	197280	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL568692	197280	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	295	3	1	4	1.9	O=c1cc2c(nn1Cc1ccc(C3CC3)cc1)CCNCC2	10.1016/j.bmcl.2009.07.063
	11160564	63274	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	CHEMBL179337	63274	4	None	-40	3	Human	6.1	pEC50	=	6.1	Functional	Effective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol releaseEffective concentration towards 5-hydroxytryptamine 2B receptors transfected in HEK293 cells was determined by measuring [3H]phosphoinositol release	ChEMBL	229	0	1	1	3.2	CC1CNCCc2c(Cl)cc(Cl)cc21	10.1016/j.bmcl.2004.12.080
	53320653	56770	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	CHEMBL1643673	56770	0	None	-2	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	245	2	1	5	0.9	CCN(C)c1c2c(nc3ccnn13)CCNCC2	10.1016/j.bmcl.2010.11.089
	135399666	168739	7	None	1	6	Rat	7.1	pEC50	=	7.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168739	7	None	1	6	Rat	7.1	pEC50	=	7.1	Functional	Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar ratsActivity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	12370465	12642	18	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL1187354	12642	18	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	CHEMBL500093	12642	18	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	147	2	1	1	1.7	NCC1CC1c1ccccc1	10.1021/jm801354e
	162657367	183658	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4756903	183658	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	CHEMBL4803034	183658	0	None	-32	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assayAgonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay	ChEMBL	231	4	1	3	2.9	CCOc1ccc2occc2c1[C@H]1C[C@@H]1CN	10.1021/acs.jmedchem.6b01194
	118733762	120618	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416033	120618	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546889	120618	0	None	-6	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	225	4	1	2	2.8	CCOc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	11437171	83461	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83461	0	None	-2	3	Human	7.1	pEC50	=	7.1	Functional	Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayActivity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assay	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	168286640	192904	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5194223	192904	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222252	192904	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	376	1	3	2	4.5	Oc1c(Br)cccc1C1NCCc2c1[nH]c1ccc(Cl)cc21	10.1021/acsmedchemlett.1c00694
	168294430	192983	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	192983	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	192983	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	168294430	192983	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5205429	192983	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	CHEMBL5222746	192983	0	None	-1	3	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	316	1	3	2	3.9	Oc1c(Cl)cccc1C1NCCc2c1[nH]c1ccc(F)cc21	10.1021/acsmedchemlett.1c00694
	24826868	91053	1	None	1	3	Human	8.1	pEC50	=	8.1	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	91053	1	None	1	3	Human	8.1	pEC50	=	8.1	Functional	Partial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assayPartial agonist activity at human 5-HT2B receptor expressed in HEK293E cells assessed as increase in intracellular calcium level by FLIPR assay	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	11695000	89042	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89042	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89042	0	None	-7	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	122461343	138337	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138337	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138337	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	7153	97992	77	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	CHEMBL272942	97992	77	None	1	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysisAgonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	ChEMBL	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	10.1016/j.bmc.2007.10.100
	154699445	177402	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	CHEMBL4638592	177402	0	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Antagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assayAntagonist activity at human Gq-coupled 5HT2B receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced calcium mobilization by calcium-sensitive dye based FLIPR assay	ChEMBL	319	4	0	4	4.2	CCP(=O)(OC)c1ccc2oc(-c3ccc(F)cc3)nc2c1	10.1021/acs.jmedchem.0c00807
	122461343	138337	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769704	138337	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771398	138337	0	None	-9	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	255	5	1	2	3.1	C=CCOc1ccc(F)c(Cl)c1C1CC1CN	10.1021/acs.jmedchem.5b01153
	11514226	89081	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	89081	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	89081	0	None	-85	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assayAgonist activity at 5-HT2B receptor in HEK293E cells assessed as elevation of intracellular calcium level measured for 90 secs by FLIPR assay	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	45484661	198858	0	None	-2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	CHEMBL584210	198858	0	None	-2	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assayAgonist activity at human recombinant 5HT2B receptor assessed as induction of calcium mobilization by FLIPR assay	ChEMBL	289	2	1	4	1.6	O=c1cc2c(nn1Cc1ccccc1Cl)CCNCC2	10.1016/j.bmcl.2009.07.063
	53325935	56767	0	None	-17	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	CHEMBL1643670	56767	0	None	-17	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	243	1	1	5	0.6	c1cc2nc3c(c(N4CCC4)n2n1)CCNCC3	10.1016/j.bmcl.2010.11.089
	53324630	56773	0	None	-18	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	CHEMBL1643676	56773	0	None	-18	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assayAgonist activity at human recombinant 5HT2B receptor expressed in CHOK1 cells assessed as induction of intracellular calcium release by FLIPR assay	ChEMBL	353	3	1	6	1.8	Fc1ccccc1OC1CN(c2c3c(nc4ccnn24)CCNCC3)C1	10.1016/j.bmcl.2010.11.089
	11658860	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	2941	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	4374	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	CHEMBL360328	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	DB04871	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayAgonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assay	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2010.11.120
	11658860	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	2941	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	4374	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	CHEMBL360328	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	DB04871	2329	51	None	-35	11	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysisAgonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintillation counting analysis	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm5019274
	122442275	138336	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138336	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138336	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	122442275	138336	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3770862	138336	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	CHEMBL3771397	138336	0	None	-11	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	ChEMBL	261	5	1	2	2.9	NCC1CC1c1c(OCCF)ccc(F)c1Cl	10.1021/acs.jmedchem.5b01153
	168288743	192923	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192923	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192923	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	4543677	192766	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192766	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192766	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	4543677	192766	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5179287	192766	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5221372	192766	1	None	-2	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	310	1	2	1	4.7	Cc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(C)c1	10.1021/acsmedchemlett.1c00694
	168288743	192923	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5192627	192923	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5222395	192923	0	None	1	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assayAgonist activity at human 5HT2B receptor stably expressed in Flp-In-T-REx-293 cells assessed as increase in Gq-mediated calcium flux by Fluo-4 direct dye based FLIPR Tetra assay	ChEMBL	326	3	2	3	3.6	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(OC)c1	10.1021/acsmedchemlett.1c00694
	118733774	120624	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3416039	120624	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	CHEMBL3546902	120624	0	None	-10	3	Human	6.0	pEC50	=	6	Functional	Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayAgonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay	ChEMBL	239	4	1	2	3.2	CC(C)Oc1ccc(Cl)cc1[C@H]1C[C@@H]1CN	10.1021/jm5019274
	46228430	199715	0	None	-8	3	Human	6.0	pEC50	=	6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL593545	199715	0	None	-8	3	Human	6.0	pEC50	=	6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assayAgonist activity against human 5HT2B receptor by FLIPR assay	ChEMBL	343	3	1	4	3.6	Clc1ccccc1O[C@@H]1CCCc2ccc(N3CCNCC3)nc21	10.1016/j.bmcl.2009.10.112
	44138039	179265	10	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	179265	10	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565847	180545	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	180545	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565831	180412	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	180412	0	None	-	1	Human	9.4	pIC50	=	9.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565608	179244	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	179244	0	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	188	3366	80	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3366	80	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3366	80	None	-	1	Human	9.2	pIC50	=	9.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	44565850	179709	0	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179709	0	None	-	1	Human	9.0	pIC50	=	9.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	4366334	80380	8	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214554	80380	8	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	379	3	0	4	4.6	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565638	189605	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189605	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3743171	80105	13	None	-	1	Human	7.0	pIC50	=	7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213329	80105	13	None	-	1	Human	7.0	pIC50	=	7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	145976085	163641	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204576	163641	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	145972374	164650	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4216860	164650	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	44565828	179174	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	179174	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	127035063	136461	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	CHEMBL3736149	136461	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	127037093	136483	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736252	136483	0	None	-	1	Human	5.0	pIC50	=	5	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	118464427	138309	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	138309	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	752565	138264	8	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770770	138264	8	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	273	2	3	6	1.7	COc1cccc(NC2=NC(N)=NC3(CCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	44565849	179271	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473235	179271	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	431	5	1	3	4.9	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565805	189610	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189610	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416247	141433	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384255	141433	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	393	3	0	4	4.9	CCCN1CCC2(CC1)Oc1ccc(C)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44156863	8046	0	None	-21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091206	8046	0	None	-21	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	345	3	0	6	2.8	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1016/j.bmcl.2010.02.046
	44565827	179173	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472415	179173	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccc2)cn1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565636	179243	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472986	179243	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1ccc(-c2ncccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	171096	8	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	171096	8	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565606	179216	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	179216	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565806	180084	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	180084	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168295984	192196	0	None	-8	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5204813	192196	0	None	-8	3	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	127034715	136369	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735261	136369	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035064	136446	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735911	136446	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	127034730	136414	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735643	136414	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	46830134	8185	0	None	-37	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1092241	8185	0	None	-37	2	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c(C)c3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	3781561	138573	6	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL377562	138573	6	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Br)cc3)CC21	10.1016/j.bmcl.2006.06.068
	10449757	3469	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3469	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3469	35	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	71528206	86942	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323581	86942	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	3830738	141621	7	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL385346	141621	7	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	2	0	4	5.1	CC(C)N1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565831	180412	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475245	180412	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	345	4	1	2	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	145988313	167211	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	167211	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	4203621	138963	14	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL378541	138963	14	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	2	0	5	4.3	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(Cl)cc3)CC21	10.1016/j.bmcl.2006.06.068
	3898525	139554	8	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL379734	139554	8	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	362	3	0	5	3.8	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565635	179242	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	179242	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565641	179294	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	CHEMBL473391	179294	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	353	3	1	2	4.5	O=C(c1ccc(-c2ccccc2)cc1)N1CC(c2nc3ccccc3[nH]2)C1	10.1016/j.bmcl.2009.02.126
	44565829	179194	2	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472589	179194	2	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	0	3	5.5	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3o2)CC1	10.1016/j.bmcl.2009.02.126
	53327611	69725	0	None	-154	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	CHEMBL1935601	69725	0	None	-154	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	401	2	1	5	3.6	O=S(=O)(c1cccc(F)c1)c1ccc2c3c(oc2c1)C1(CCCOC1)NCC3	10.1016/j.bmcl.2011.11.050
	44416290	141359	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL383860	141359	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	424	4	0	5	4.7	c1ccc(CCN2CCC3(CC2)Oc2ccccc2C2CC(c4ccncc4)=NN23)cc1	10.1016/j.bmcl.2006.06.068
	44565824	179269	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	179269	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44155109	8142	4	None	-21	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091919	8142	4	None	-21	2	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	373	3	0	6	3.5	CSc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	732268	138271	33	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770837	138271	33	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	44565635	179242	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472985	179242	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2ccccn2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3716424	81021	6	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215380	81021	6	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC(F)F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3826158	79898	12	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212506	79898	12	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	469	4	0	5	5.2	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(OC)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	118464428	138236	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770512	138236	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	4	3	7	2.6	CCCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	145988313	167211	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	167211	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assayAntagonist activity at recombinant human 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced calcium flux preincubated for 60 mins at 37 degC followed by incubation at room temperature for 15 mins and subsequent addition of serotonin and measured for 100 secs in presence of human serum albumin by fluorescence assay	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	136020618	163890	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4207302	163890	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	3736302	138893	7	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL378357	138893	7	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	439	2	0	4	5.2	CC(C)N1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	188	3366	80	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	196968	3366	80	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	CHEMBL473186	3366	80	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1016/j.bmcl.2009.02.126
	145979048	166634	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL4281546	166634	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	407	3	3	7	3.0	CCOC(=O)c1cc(Br)cc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	44565846	180544	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	180544	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	16812804	171096	8	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL445809	171096	8	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	3	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565830	179698	2	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179698	2	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189669	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189669	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416309	141416	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384160	141416	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	376	3	0	5	4.1	CC(C)CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	145993660	167345	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4294723	167345	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	413	1	3	5	3.6	NC1=NC2(CCCCC2)NC(Nc2cc(Br)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	44565637	179266	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473187	179266	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	398	3	2	3	3.9	O=C(c1ccc(-c2ccccc2)[nH]c1=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	71528204	86940	0	None	-15	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323579	86940	0	None	-15	3	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	118464429	167093	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4290245	167093	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	26694436	162888	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4173963	162888	2	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	354	5	2	3	2.9	CC(C)NS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(F)c2)c1	10.1021/acs.jmedchem.8b00654
	44565807	180086	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474840	180086	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	390	3	1	4	3.4	O=C(c1ccc(N2CCOCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416259	138178	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL376978	138178	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	397	3	0	4	4.7	CCCN1CCC2(CC1)Oc1ccc(F)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	3649661	138194	7	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	138194	7	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	11502243	189482	48	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	189482	48	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11949710	199879	0	None	-50	3	Human	7.6	pIC50	=	7.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	199879	0	None	-50	3	Human	7.6	pIC50	=	7.6	Functional	Agonist activity against human 5HT2B receptor by FLIPR assay relative to 5HTAgonist activity against human 5HT2B receptor by FLIPR assay relative to 5HT	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	5093797	81044	7	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215461	81044	7	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Cl)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	895660	32363	8	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL1411080	32363	8	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	287	2	3	6	2.0	COc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	118464425	138284	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	138284	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5113614	80032	7	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213005	80032	7	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	457	3	0	4	5.3	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565808	180887	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	180887	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11502243	189482	48	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	CHEMBL513994	189482	48	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmcl.2009.02.126
	11957541	1446	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	1229	1446	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	147	1446	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	170617	1446	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	CHEMBL6616	1446	40	None	1	4	Human	8.5	pIC50	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	3723094	79935	10	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212656	79935	10	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	429	1	0	4	4.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565608	179244	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472990	179244	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	385	4	1	3	3.8	O=S(=O)(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565846	180544	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475406	180544	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	395	4	1	2	5.3	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	168284710	191569	0	None	-18	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5195241	191569	0	None	-18	3	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR methodAntagonist activity at 5-HT2B receptor (unknown origin) incubated for 60 mins followed by 10 mins incubation in dark at room temperature by FLIPR method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	136020617	57293	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL1651095	57293	0	None	-	1	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	44565805	189610	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514967	189610	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.6	O=C(c1ccc(C2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44416260	79962	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212755	79962	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	413	3	0	4	5.2	CCCN1CCC2(CC1)Oc1ccc(Cl)cc1C1CC(c3ccc(F)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565847	180545	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL475407	180545	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	3	3.6	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565808	180887	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL475778	180887	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	411	4	1	3	5.3	COc1ccc(-c2ccc(C(=O)N3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	11248240	2646	4	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	5601	2646	4	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	CHEMBL175543	2646	4	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	462	5	4	8	1.8	CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl	10.1021/acs.jmedchem.6b01183
	752521	198714	8	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	198714	8	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	118464420	138220	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	138220	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	44565634	179217	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472791	179217	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.6	O=C(c1ccc(-c2cccnc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565850	179709	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474408	179709	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	349	3	1	2	4.2	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	118464420	138220	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770342	138220	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	118464426	138221	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770351	138221	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	327	4	3	6	3.0	CCCC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	3751272	80567	13	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215024	80567	13	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	443	3	0	4	5.9	Clc1ccc(C2=NN3C(C2)c2ccccc2OC32CCN(Cc3ccccc3)CC2)cc1	10.1016/j.bmcl.2006.06.068
	71528205	86941	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323580	86941	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection methodAntagonist activity at human 5-HT2B receptor transfected in CHO cell assessed as decrease in 5-HT-induced IP1 production preincubated for 5 mins before 5-HT addition measured after 30 mins by HTRF detection method	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	145963830	164099	0	None	3	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4209942	164099	0	None	3	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	127035065	136475	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	CHEMBL3736207	136475	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	44565606	179216	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472789	179216	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	411	4	1	3	5.3	COc1cc(-c2ccccc2)ccc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	73389570	161978	38	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	CHEMBL4159471	161978	38	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	378	5	2	4	2.5	Cc1cc(NC(=O)c2cccc(S(=O)(=O)N[C@H]3CCOC3)c2)ccc1F	10.1021/acs.jmedchem.8b00654
	2884131	166884	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286420	166884	7	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	44155107	8047	4	None	-60	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	CHEMBL1091207	8047	4	None	-60	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetryAntagonist activity at human 5HT2B receptor in HEK293 cells assessed as inhibition of alpha-ME-5-HT-induced cAMP accumulation pretreated for 15 secs before alphaME-5-HT addition by Fura-2AM dye based spectrofluorimetry	ChEMBL	359	3	0	6	3.2	CSc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1016/j.bmcl.2010.02.046
	4297073	81272	7	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215883	81272	7	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	348	2	0	5	3.4	CCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	46933845	16130	0	None	-18	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16130	0	None	-18	2	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assayAntagonist activity at human 5HT2B receptor assessed as inhibition of 10633-induced calcium mobilization by FLIPR assay	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	135753059	190694	5	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5182403	190694	5	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	4	2	5	2.7	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccc(C)c(C)c2)n1	10.1021/acs.jmedchem.1c01759
	135753074	191084	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5187824	191084	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	135753056	191151	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5188949	191151	2	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	156208582	192009	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	CHEMBL5202029	192009	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assayAntagonist activity at 5-HT2B receptor (unknown origin) transfected in HEK293 cells assessed as beta-arrestin translocation by Tango assay	ChEMBL	351	5	2	5	2.6	CCc1cccc(C(=O)Nc2cc(C)nn2-c2nc(CC)cc(=O)[nH]2)c1	10.1021/acs.jmedchem.1c01759
	3765560	141520	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384745	141520	9	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4518239	81028	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215404	81028	6	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	477	3	0	5	5.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3OC(F)F)=NN12	10.1016/j.bmcl.2006.06.068
	879244	28168	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL1373650	28168	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	4322819	80394	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	CHEMBL214594	80394	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	381	2	0	5	3.8	COc1cccc2c1OC1(CCN(C)CC1)N1N=C(c3ccc(F)cc3)CC21	10.1016/j.bmcl.2006.06.068
	118464421	167268	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4293638	167268	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	44247568	82145	55	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	CHEMBL2170062	82145	55	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human 5HT2B receptorAntagonist activity at human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	44565806	180084	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474839	180084	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	388	3	1	3	4.6	O=C(c1ccc(N2CCCCC2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	2267399	138316	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771373	138316	8	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	271	1	3	5	2.3	Cc1ccc(NC2=NC(N)=NC3(CCCCC3)N2)cc1	10.1021/acs.jmedchem.5b01631
	136928971	138204	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770185	138204	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	343	3	3	7	2.5	CCOC(=O)c1cccc(NC2=NC(NC)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	5128094	79828	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212228	79828	18	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	333	1	0	4	3.7	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	5167627	80033	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL213006	80033	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	395	3	0	4	5.1	CCCN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44416351	80106	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	CHEMBL213332	80106	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	279	1	0	4	3.4	CC1(C)Oc2ccccc2C2CC(c3ccncc3)=NN21	10.1016/j.bmcl.2006.06.068
	3802375	80288	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214184	80288	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	453	3	0	4	5.5	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(C)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	4657811	80490	8	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL214802	80490	8	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	461	1	0	4	5.6	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc4ccccc4c3)=NN12	10.1016/j.bmcl.2006.06.068
	5165122	81022	20	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	CHEMBL215386	81022	20	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1	10.1016/j.bmcl.2006.06.068
	3757038	81444	11	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL215991	81444	11	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	401	1	0	5	4.0	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccco3)=NN12	10.1016/j.bmcl.2006.06.068
	3773677	138960	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	CHEMBL378540	138960	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	441	2	0	5	4.4	COc1ccccc1C1=NN2C(C1)c1cc(Br)ccc1OC21CCN(C)CC1	10.1016/j.bmcl.2006.06.068
	3410378	141437	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384270	141437	7	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	417	1	0	5	4.5	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3cccs3)=NN12	10.1016/j.bmcl.2006.06.068
	4679720	165953	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	CHEMBL425260	165953	6	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	471	3	0	6	4.4	COc1ccc(C2=NN3C(C2)c2cc(Br)ccc2OC32CCN(C)CC2)cc1OC	10.1016/j.bmcl.2006.06.068
	4148445	138276	9	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770873	138276	9	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assayAntagonist activity at 5-HT2B receptor (unknown origin) expressed in CHO-K1 cells assessed as calcium flux after 60 mins by FLIPR assay	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2ccc(Cl)cc2)=N1	10.1021/acs.jmedchem.5b01631
	3391669	141816	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL386459	141816	7	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	479	1	0	4	5.7	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Cl)c(Cl)c3)=NN12	10.1016/j.bmcl.2006.06.068
	44565607	189541	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	189541	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	179270	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	179270	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565826	179172	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL472414	179172	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	387	3	1	2	5.2	O=C(C1CCC(c2ccccc2)CC1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44476436	82318	6	None	-7413	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	CHEMBL2172186	82318	6	None	-7413	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining methodAntagonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alphamethyl5HT-induced intracellular calcium mobilization by Fluo4-based staining method	ChEMBL	357	3	1	7	1.6	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CN(C)CC3	10.1016/j.bmcl.2012.05.036
	162674022	183197	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	183197	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assayAntagonist activity at 5-HT2B receptor (unknown origin) assessed as inhibition of 5HT-indued response by calcium mobilization assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	127037059	136512	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736516	136512	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	10449757	3469	35	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	190	3469	35	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	CHEMBL2110371	3469	35	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10.1016/j.bmcl.2009.02.126
	44565639	179293	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	179293	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	44565640	189481	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL513993	189481	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	382	3	1	3	4.2	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44138039	179265	10	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473185	179265	10	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	363	4	1	2	4.3	O=C(c1ccc(-c2ccc(F)cc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565605	189669	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL515422	189669	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	383	3	1	4	4.0	O=C(c1cnc(-c2ccccc2)nc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565639	179293	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	CHEMBL473387	179293	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	367	4	1	2	5.6	c1ccc(-c2ccc(CN3CCC(c4nc5ccccc5[nH]4)CC3)cc2)cc1	10.1016/j.bmcl.2009.02.126
	145989393	167199	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4292168	167199	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assayAntagonist activity at 5HT2B (unknown origin) expressed in CHOK1 cells assessed as inhibition of agonist-induced effect preincubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent agonist addition measured for 100 secs by fluorescence assay	ChEMBL	353	1	3	5	2.9	NC1=NC2(CCCCC2)NC(Nc2cc(F)cc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	3473601	140104	6	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL380167	140104	6	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	367	1	0	4	4.3	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	44565830	179698	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL474404	179698	2	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	331	3	1	2	4.1	O=C(c1ccc(-c2ccccc2)cc1)N1CCC(c2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	57495353	125014	38	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	CHEMBL3643413	125014	38	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of 5-HT2B (unknown origin) by calcium flux assayInhibition of 5-HT2B (unknown origin) by calcium flux assay	ChEMBL	450	5	1	7	2.9	CCC(=O)N1CC[C@H](Nc2ncnc3c2CN(c2cnc(OC)c(C(F)(F)F)c2)CC3)C1	10.1021/acsmedchemlett.7b00293
	3400827	79884	11	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212457	79884	11	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	517	3	0	4	6.0	CCCN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccc(Br)cc3)=NN12	10.1016/j.bmcl.2006.06.068
	127035062	136426	0	None	6	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	136426	0	None	6	3	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	127035066	136396	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735434	136396	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assayAntagonist activity at human recombinant 5-HT2B receptor expressed in Flp-In HEK cells in the presence of agonist preincubated for 10 mins by FLIPR based calcium mobilization assay	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	44565828	179174	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	CHEMBL472416	179174	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	395	3	0	3	5.3	Cn1c(C2CCN(C(=O)c3ccc(-c4ccccc4)cc3)CC2)nc2ccccc21	10.1016/j.bmcl.2009.02.126
	145964159	164305	0	None	8	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	164305	0	None	8	2	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) by calcium release assayAntagonist activity at 5-HT2B receptor (unknown origin) by calcium release assay	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44565638	189605	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514934	189605	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	417	4	1	3	4.8	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3499360	141495	7	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL384579	141495	7	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	445	1	0	4	5.1	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3Cl)=NN12	10.1016/j.bmcl.2006.06.068
	104697662	145380	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	CHEMBL3914002	145380	1	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	11536299	183262	8	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	CHEMBL479683	183262	8	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilizationAntagonist activity at 5-HT2B receptor (unknown origin) expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	109052212	162523	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	CHEMBL4168125	162523	1	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at 5-HT2B (unknown origin)Antagonist activity at 5-HT2B (unknown origin)	ChEMBL	340	4	2	2	4.1	O=C(Nc1ccc(F)cc1)c1cccc(C(=O)NC2CCCCC2)c1	10.1021/acs.jmedchem.8b00654
	44565607	189541	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL514453	189541	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	427	5	1	5	4.4	CCOc1nc(-c2ccccc2)ncc1C(=O)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	3442850	169537	20	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL443570	169537	20	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	411	1	0	4	4.4	CN1CCC2(CC1)Oc1ccc(Br)cc1C1CC(c3ccccc3)=NN12	10.1016/j.bmcl.2006.06.068
	4895014	79971	7	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	CHEMBL212780	79971	7	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium releaseActivity at 5HT2B receptor expressed in CHO cell assessed as inhibition of alpha-methyl-5HT-stimulated calcium release	ChEMBL	334	1	0	5	3.0	CN1CCC2(CC1)Oc1ccccc1C1CC(c3ccncc3)=NN12	10.1016/j.bmcl.2006.06.068
	44565824	179269	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473214	179269	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assayAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay	ChEMBL	465	4	1	3	6.1	O=C(c1ccc(-c2ccc(OC(F)(F)F)cc2)cc1)N1CCC(c2nc3ccccc3[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	44565848	179270	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	CHEMBL473234	179270	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albuminAntagonist activity at 5-HT2B receptor expressed in CHOK1 cells assessed as inhibition of serotonin-induced intracellular Ca2+ flux by aequorin luminescence assay in presence of 4% human serum albumin	ChEMBL	381	5	1	3	3.7	O=S(=O)(c1ccc(-c2ccccc2)cc1)N1CCC(Cc2ncc[nH]2)CC1	10.1016/j.bmcl.2009.02.126
	12611598	60407	6	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60407	6	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	221	3465	71	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	3277600	3465	71	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	CHEMBL323356	3465	71	None	-	3	Rat	8.0	pKd	=	8.0	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	10.1021/jm00006a001
	44385952	62178	5	None	-	0	Rat	7.9	pKd	=	7.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	CHEMBL177800	62178	5	None	-	0	Rat	7.9	pKd	=	7.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	135398737	955	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	38	955	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	722	955	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	CHEMBL42	955	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	DB00363	955	93	None	-	43	Rat	6.9	pKd	=	6.9	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
	10022745	119943	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	CHEMBL349832	119943	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	381	5	1	4	3.5	CCc1c(C)[nH]c2c1C(=O)CC(CN1CCN(c3ccccc3OC)CC1)C2	10.1021/jm011014y
	44327167	9346	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL111393	9346	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL544319	9346	0	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm011014y
	12611606	60348	9	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	CHEMBL174723	60348	9	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	12611609	60406	6	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	CHEMBL175204	60406	6	None	-	0	Rat	6.9	pKd	=	6.9	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	12611617	60325	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174563	60325	3	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	12611598	60407	6	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	CHEMBL175205	60407	6	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(O)c(CC(C)N)c1	10.1021/jm00183a006
	10356829	59661	0	None	-	0	Rat	7.8	pKd	=	7.8	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	CHEMBL172269	59661	0	None	-	0	Rat	7.8	pKd	=	7.8	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	289	2	2	4	4.3	Cc1cc(NC(=O)Nc2ccc3sccc3c2)sn1	10.1021/jm00006a001
	10693836	9305	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL111189	9305	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL545488	9305	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10715378	15486	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	CHEMBL121744	15486	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	389	4	1	4	3.7	COc1ccccc1N1CCN(CC2CC(=O)c3c([nH]c4ccccc34)C2)CC1	10.1021/jm011014y
	9979654	207896	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL96781	207896	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611613	60430	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	CHEMBL175328	60430	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	10473483	8618	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL109528	8618	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	CHEMBL544318	8618	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	356	4	0	5	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccsc3C2)CC1	10.1021/jm011014y
	135398737	955	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	38	955	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	722	955	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	CHEMBL42	955	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	DB00363	955	93	None	-	43	Rat	6.8	pKd	=	6.8	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm011014y
	10710246	121101	0	None	-	0	Rat	5.7	pKd	=	5.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL357517	121101	0	None	-	0	Rat	5.7	pKd	=	5.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34657	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143022	34657	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B) receptor	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
	10338282	34657	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143022	34657	1	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm011014y
	11760018	53335	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL160019	53335	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	354	5	0	5	3.2	COc1ccccc1N1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	44326982	8627	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL109548	8627	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL545727	8627	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm011014y
	10090486	53242	0	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	CHEMBL159929	53242	0	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	369	5	0	4	4.1	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3occc3C2=O)CC1	10.1021/jm011014y
	10090424	34667	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143027	34667	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
	10090424	34667	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143027	34667	1	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm011014y
	12611604	60417	4	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)c(O)c1	10.1021/jm00183a006
	CHEMBL175272	60417	4	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)c(O)c1	10.1021/jm00183a006
	10645469	110530	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL325253	110530	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL542428	110530	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611615	60305	1	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174449	60305	1	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	12611617	60325	3	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174563	60325	3	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	4	1	3	1.5	COc1ccc(O)c(CCN(C)C)c1	10.1021/jm00183a006
	10024430	207590	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL95098	207590	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	12611613	60430	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	CHEMBL175328	60430	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	209	4	1	3	1.9	COc1ccc(O)c(CC(C)N(C)C)c1	10.1021/jm00183a006
	44327153	109183	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	CHEMBL321682	109183	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	CHEMBL558817	109183	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determinedAntagonistic activity on 5-hydroxytryptamine 2B receptor of Rat stomach fundus;ND is not determined	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm011014y
	10804995	35551	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm0009890
	CHEMBL143937	35551	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm0009890
	10804995	35551	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL143937	35551	0	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	311	3	0	5	2.2	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2occc21	10.1021/jm011014y
	197139	25040	26	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	CHEMBL1347	25040	26	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	12611606	60348	9	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	CHEMBL174723	60348	9	None	-	0	Rat	5.5	pKd	=	5.5	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	181	3	2	3	1.3	COc1ccc(CC(C)N)cc1O	10.1021/jm00183a006
	12611596	60274	6	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	CHEMBL174380	60274	6	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	12611615	60305	1	None	-	0	Rat	5.4	pKd	=	5.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	CHEMBL174449	60305	1	None	-	0	Rat	5.4	pKd	=	5.4	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	285	7	0	3	3.4	COc1ccc(OCc2ccccc2)c(CCN(C)C)c1	10.1021/jm00183a006
	9951008	206374	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87717	206374	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm011014y
	126769	206019	42	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	CHEMBL536255	206019	42	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	CHEMBL85194	206019	42	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00006a001
	9930475	206267	0	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87026	206267	0	None	-	0	Rat	7.4	pKd	=	7.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm011014y
	10597019	34237	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	CHEMBL142668	34237	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	10597019	34237	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL142668	34237	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	7	0	5	3.4	O=C(CCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10249506	8773	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL109673	8773	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL544091	8773	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	11141324	53063	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	307	3	0	4	2.6	O=C1CC(CN2CCN(c3ccccn3)CC2)c2ccccc21	10.1021/jm011014y
	CHEMBL159771	53063	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	307	3	0	4	2.6	O=C1CC(CN2CCN(c3ccccn3)CC2)c2ccccc21	10.1021/jm011014y
	9866660	114395	2	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	417	3	1	4	5.1	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	CHEMBL333174	114395	2	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	417	3	1	4	5.1	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	10061837	120714	0	None	-	0	Rat	7.3	pKd	=	7.3	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	273	2	2	4	3.8	Cc1cc(NC(=O)Nc2ccc3sccc3c2)on1	10.1021/jm00006a001
	CHEMBL354951	120714	0	None	-	0	Rat	7.3	pKd	=	7.3	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	273	2	2	4	3.8	Cc1cc(NC(=O)Nc2ccc3sccc3c2)on1	10.1021/jm00006a001
	10022781	57024	0	None	-	0	Rat	6.3	pKd	=	6.3	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	382	4	0	5	4.6	O=C1c2ccoc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL164471	57024	0	None	-	0	Rat	6.3	pKd	=	6.3	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	382	4	0	5	4.6	O=C1c2ccoc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	44326751	108588	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL320572	108588	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL539544	108588	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm011014y
	10693017	33807	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	CHEMBL142316	33807	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm0009890
	10367486	9262	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL110948	9262	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	CHEMBL543613	9262	1	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm011014y
	10693017	33807	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL142316	33807	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	412	8	0	5	3.8	O=C(CCCCN1CCN(CC2CC(=O)c3ccoc3C2)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10069784	14951	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	404	4	1	3	4.6	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	CHEMBL120903	14951	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	404	4	1	3	4.6	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2[nH]c3ccccc3c21	10.1021/jm011014y
	15021876	103383	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm011014y
	CHEMBL308480	103383	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm011014y
	10809188	9243	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL110847	9243	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL540822	9243	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm011014y
	10497359	121711	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm0009890
	CHEMBL358895	121711	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Compound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptorCompound was evaluated for antagonism against serotonin (5-hydroxytryptamine 2B receptor ) receptor	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm0009890
	10497359	121711	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm011014y
	CHEMBL358895	121711	0	None	-	0	Rat	6.2	pKd	=	6.2	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	340	4	0	5	2.9	COc1ccccc1N1CCN(CC2CC(=O)c3ccoc3C2)CC1	10.1021/jm011014y
	197139	25040	26	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	CHEMBL1347	25040	26	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	181	3	2	3	1.3	COc1cc(CC(C)N)ccc1O	10.1021/jm00183a006
	11023903	52725	0	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	327	3	0	5	2.7	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2sccc21	10.1021/jm011014y
	CHEMBL159466	52725	0	None	-	0	Rat	5.2	pKd	=	5.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	327	3	0	5	2.7	O=C1CC(CN2CCN(c3ccccn3)CC2)Cc2sccc21	10.1021/jm011014y
	10015954	165215	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	270	2	2	4	3.1	Cc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)on1	10.1021/jm00006a001
	CHEMBL422923	165215	1	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Antagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundusAntagonistic affinity measured as pA2 value on 5-hydroxytryptamine 2B receptor of the rat stomach fundus	ChEMBL	270	2	2	4	3.1	Cc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)on1	10.1021/jm00006a001
	9886130	206407	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87943	206407	0	None	-	0	Rat	7.2	pKd	=	7.2	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	10622347	54374	0	None	-	0	Rat	5.1	pKd	=	5.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	426	8	0	4	4.0	O=C(CCCN1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	CHEMBL160907	54374	0	None	-	0	Rat	5.1	pKd	=	5.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	426	8	0	4	4.0	O=C(CCCN1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm011014y
	10044334	207098	18	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL92145	207098	18	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm011014y
	12611596	60274	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	CHEMBL174380	60274	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(CC(C)N)c(O)cc1C	10.1021/jm00183a006
	44385952	62178	5	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	CHEMBL177800	62178	5	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic against 5-hydroxytryptamine 2B receptorAntagonistic against 5-hydroxytryptamine 2B receptor	ChEMBL	195	3	2	3	1.6	COc1cc(C)c(O)cc1CC(C)N	10.1021/jm00183a006
	9951964	206335	0	None	-	0	Rat	6.1	pKd	=	6.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL87458	206335	0	None	-	0	Rat	6.1	pKd	=	6.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm011014y
	12611609	60406	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	CHEMBL175204	60406	6	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparationAntagonistic activity against 5-hydroxytryptamine 2B receptor obtained from rat stomach fundus preparation	ChEMBL	167	3	2	3	0.9	COc1ccc(O)c(CCN)c1	10.1021/jm00183a006
	2148	3859	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	2150	3859	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	2784	3859	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	5610	3859	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	CHEMBL11608	3859	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	DB08841	3859	114	None	-	6	Rat	5.1	pKd	=	5.1	Functional	Antagonistic activity of corresponding methoxy compound against serotonin 5-HT receptorAntagonistic activity of corresponding methoxy compound against serotonin 5-HT receptor	ChEMBL	137	2	2	2	0.9	NCCc1ccc(cc1)O	10.1021/jm00183a006
	10022123	53286	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL159969	53286	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	CHEMBL92673	53286	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm011014y
	10544858	170004	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	CHEMBL444269	170004	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	CHEMBL542181	170004	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm011014y
	11121409	56372	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	341	4	0	5	3.1	O=C1c2ccsc2CCC1CCN1CCN(c2ccccn2)CC1	10.1021/jm011014y
	CHEMBL163180	56372	0	None	-	0	Rat	7.0	pKd	=	7.0	Functional	Negative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonist was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	341	4	0	5	3.1	O=C1c2ccsc2CCC1CCN1CCN(c2ccccn2)CC1	10.1021/jm011014y
	10710246	121101	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm011014y
	CHEMBL357517	121101	0	None	-	0	Rat	6.0	pKd	=	6.0	Functional	Negative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundusNegative log concentration of antagonistic compound was determined on 5-hydroxytryptamine 2B receptor of Rat stomach fundus	ChEMBL	312	3	0	6	1.6	O=C1CC(CN2CCN(c3ncccn3)CC2)Cc2occc21	10.1021/jm011014y
	10017554	4309	29	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandAntagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	CHEMBL101008	4309	29	None	-	0	Human	8.9	pKi	=	8.9	Functional	Antagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandAntagonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	10017554	4309	29	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligandAgonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	CHEMBL101008	4309	29	None	-	0	Human	8.8	pKi	=	8.8	Functional	Agonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligandAgonistic activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]-5-HT as radioligand	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm960199j
	134143752	150625	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3955519	150625	0	None	-	0	Human	8.7	pKi	=	8.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	49836525	18775	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278202	18775	0	None	-	0	Human	8.0	pKi	=	8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	CC1(C(=O)O)CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836524	18774	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278201	18774	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	2	1	2	4.0	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	46933091	15731	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222695	15731	0	None	-	0	Human	7.0	pKi	=	7	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(Cl)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836526	18616	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276859	18616	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	3	1	2	4.4	O=C(O)CC1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836411	18693	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277585	18693	0	None	-	0	Human	6.0	pKi	=	6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	3	1	2	4.8	O=C(O)CC1CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	44516817	57633	5	None	-1023	2	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilizationAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	CHEMBL1668584	57633	5	None	-1023	2	Human	6.0	pKi	=	6.0	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilizationAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	185	3975	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	5311271	3975	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	CHEMBL74355	3975	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	DB16351	3975	60	None	-	1	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10.1021/jm100856p
	49836412	18692	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277584	18692	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)[C@@H]1CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836294	18747	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1278020	18747	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	387	2	0	3	4.4	COC(=O)C1=CCCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836522	18763	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	CHEMBL1278113	18763	0	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	376	2	2	3	3.0	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CCN1	10.1021/jm100856p
	52944115	18766	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	CHEMBL1278116	18766	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	291	1	0	1	4.2	CN(C)C1CC[C@]2(Cc3ccccc3Cc3ccccc32)C1	10.1021/jm100856p
	49833883	15729	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222693	15729	0	None	-	0	Human	7.8	pKi	=	7.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	394	4	1	5	3.1	Cc1nc2n(c1C)Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	44156754	6478	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	CHEMBL1082763	6478	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	49836299	18712	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277770	18712	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	375	2	1	2	4.4	O=C(O)C1CCN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49833886	15746	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222764	15746	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	396	5	1	6	2.5	COc1cnc2n1Cc1ccccc1C=C2N1CCN(CC(C)(C)C(=O)O)CC1	10.1016/j.bmcl.2010.07.029
	49836639	18652	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277216	18652	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	377	2	1	3	4.6	O=C(O)C1CCN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)CC1	10.1021/jm100856p
	46933089	15701	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222554	15701	0	None	-	0	Human	5.8	pKi	=	5.8	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.5	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3ccnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	46867519	6476	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2cc3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	CHEMBL1082761	6476	4	None	-	0	Human	6.8	pKi	=	6.8	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.5	CNc1nn2cc3c(nc2c1S(=O)(=O)c1ccccc1)CCCC3	10.1021/jm100350r
	44156752	6548	4	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.4	CNc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	CHEMBL1083075	6548	4	None	-	0	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	342	3	1	6	2.4	CNc1nn2c3c(c(C)nc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	10609802	107165	2	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	CHEMBL316527	107165	2	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	155531067	171595	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4465512	171595	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	134141831	146662	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3923870	146662	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	49833882	15728	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15728	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	46933090	15744	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222762	15744	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	400	4	1	5	3.1	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3c(Cl)cnc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836635	18635	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277035	18635	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	359	2	1	2	4.0	O=C(O)C=C1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49836409	18704	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277679	18704	0	None	-	0	Human	6.6	pKi	=	6.6	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	391	2	2	3	3.5	O=C(O)C1(O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	49836300	18711	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	CHEMBL1277769	18711	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	389	2	1	2	4.8	CC1(C(=O)O)CCN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)CC1	10.1021/jm100856p
	134154065	152337	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3970041	152337	0	None	-	0	Human	8.5	pKi	=	8.5	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	11957541	1446	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	1229	1446	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	147	1446	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	170617	1446	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	CHEMBL6616	1446	40	None	1	4	Human	8.5	pKi	=	8.5	Functional	Displacement of radiolabeled DOI from human 5HT2B receptor agonist siteDisplacement of radiolabeled DOI from human 5HT2B receptor agonist site	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm8007618
	10609802	107165	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	CHEMBL316527	107165	2	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	235	3	1	4	1.1	COc1c2c(c(CCN)c3c1OCC3)CCO2	10.1021/jm970219x
	1530	2169	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	3827	2169	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	7206	2169	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	CHEMBL534	2169	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	DB00920	2169	50	None	-3	25	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1021/jm100856p
	10440	2662	20	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2662	20	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2662	20	None	-	3	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	10751567	4507	3	None	-	1	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	CHEMBL102347	4507	3	None	-	1	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligandAntagonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	49864841	15699	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	CHEMBL1222552	15699	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	266	1	1	4	1.6	C1=C(N2CCNCC2)c2nccn2Cc2ccccc21	10.1016/j.bmcl.2010.07.029
	49834053	15745	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222763	15745	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	384	4	1	5	2.6	CC(C)(CN1CCN(C2=Cc3ccccc3Cn3cc(F)nc32)CC1)C(=O)O	10.1016/j.bmcl.2010.07.029
	49836634	18634	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277034	18634	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	361	3	1	2	4.0	O=C(O)CC1CN(C2CCC3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	49833882	15728	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	CHEMBL1222692	15728	0	None	-	0	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	392	3	1	5	3.0	O=C(O)C1CCC(N2CCN(C3=Cc4ccccc4Cn4ccnc43)CC2)CC1	10.1016/j.bmcl.2010.07.029
	25110703	189696	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	360	2	1	4	3.2	O=S(=O)(c1ccccc1)n1cc(Cl)c2cc3c(cc21)CCNCC3	10.1016/j.bmcl.2008.08.010
	CHEMBL515624	189696	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at 5HT2B receptorAntagonist activity at 5HT2B receptor	ChEMBL	360	2	1	4	3.2	O=S(=O)(c1ccccc1)n1cc(Cl)c2cc3c(cc21)CCNCC3	10.1016/j.bmcl.2008.08.010
	49836528	18626	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	CHEMBL1276947	18626	0	None	-	0	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	373	2	1	2	4.0	O=C(O)[C@]12C[C@H]1CN(C1CC[C@]3(Cc4ccccc4Cc4ccccc43)C1)C2	10.1021/jm100856p
	134152052	153059	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3976121	153059	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Antagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assayAntagonist activity at human 5-HT2BR expressed in Flp-In HEK cells assessed as inhibition of 5-HT-induced calcium mobilization preincubated for 5 to 10 mins followed 5-HT addition by Fluo-4 dye based FLIPR assay	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	44156628	6682	4	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	328	3	1	6	2.1	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	CHEMBL1083654	6682	4	None	-	0	Human	6.3	pKi	=	6.3	Functional	Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometryAntagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobilization by spectrophotometry	ChEMBL	328	3	1	6	2.1	CNc1nn2c3c(cnc2c1S(=O)(=O)c1ccccc1)CCC3	10.1021/jm100350r
	10751567	4507	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	CHEMBL102347	4507	3	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	223	4	1	4	1.1	COc1cc(CCN)c2c(c1OC)OCC2	10.1021/jm970219x
	38240	107972	22	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	CHEMBL319415	107972	22	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	225	6	1	4	1.6	CCOc1c(OC)cc(CCN)cc1OC	10.1021/jm970219x
	49833884	15730	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	CHEMBL1222694	15730	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	380	4	1	5	2.8	Cc1cn2c(n1)C(N1CCN(CC(C)(C)C(=O)O)CC1)=Cc1ccccc1C2	10.1016/j.bmcl.2010.07.029
	49864886	15713	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	CHEMBL1222624	15713	0	None	-	0	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assayAntagonist activity at human 5HT2B receptor expressed in human SHSY5Y cells by FLPR assay	ChEMBL	366	4	1	5	2.6	CC1CN(C2=Cc3ccccc3Cn3ccnc32)CC(C)N1CCC(=O)O	10.1016/j.bmcl.2010.07.029
	155558626	174737	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4561016	174737	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Antagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assayAntagonist activity at human 5HT2B receptor expressed in Flp-In-HEK cells co-expressing Gq assessed as inhibition of 5HT-induced stimulation of calcium mobilization preincubated for 10 mins followed by 5HT addition by fluo-4 calcium dye-based FLIPR assay	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	49836633	18627	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1276948	18627	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	347	2	1	2	3.6	O=C(O)C1CN(C2CC[C@]3(Cc4ccccc4Cc4ccccc43)C2)C1	10.1021/jm100856p
	25184832	18663	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	CHEMBL1277312	18663	0	None	-	0	Human	6.1	pKi	=	6.1	Functional	Antagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assayAntagonist activity at human 5HT2B receptor expressed in human SH-SY5Y cells by FLIPR assay	ChEMBL	349	2	1	3	3.8	O=C(O)C1CN(C2CCC3(Cc4ccccc4Oc4ccccc43)C2)C1	10.1021/jm100856p
	13139	2474	29	None	-	2	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	4076	2474	29	None	-	2	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	CHEMBL26687	2474	29	None	-	2	Human	6.1	pKi	=	6.1	Functional	Agonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligandAgonist activity at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT radioligand	ChEMBL	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	10.1021/jm970219x
	2995	204382	53	None	-154	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL1696	204382	53	None	-154	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	CHEMBL72	204382	53	None	-154	18	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
	1225	1459	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	1459	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	1459	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	1459	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	1459	26	None	-3	11	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	2105	3032	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	None	-3	25	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	439280	119993	107	None	-25	9	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	6971044	119993	107	None	-25	9	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	CHEMBL350221	119993	107	None	-25	9	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayAgonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assay	Drug Central	220	3	4	3	0.8	N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(=O)O	None
	11658860	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	2941	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	4374	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	CHEMBL360328	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	DB04871	2329	51	None	-35	11	Human	6.0	pEC50	=	6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	30699	217676	0	None	-1	14	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	423	7	2	8	0.5	CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O	None
	5215	168943	102	None	1	3	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	250	3	2	5	0.9	Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1	None
	CHEMBL439	168943	102	None	1	3	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	250	3	2	5	0.9	Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1	None
	4421	217689	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	232	2	1	4	1.4	CCN1C=C(C(O)=O)C(=O)C2=CC=C(C)N=C12	None
	14052	172554	51	None	1	5	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	204	9	4	4	-0.3	CC[C@@H](CO)NCCN[C@@H](CC)CO	None
	CHEMBL44884	172554	51	None	1	5	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	204	9	4	4	-0.3	CC[C@@H](CO)NCCN[C@@H](CC)CO	None
	33613	217668	0	None	-1	3	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	365	4	4	6	0.0	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)C3=CC=C(O)C=C3)C(=O)N2[C@H]1C(O)=O	None
	2337	3232	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	None	-11	29	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	2585	800	103	None	-18	22	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	522	800	103	None	-18	22	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	551	800	103	None	-18	22	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	CHEMBL723	800	103	None	-18	22	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	DB01136	800	103	None	-18	22	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
	1343	1876	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1876	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1876	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1876	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1876	62	None	-14	9	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	54477	84624	36	None	-	23	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	CHEMBL22242	84624	36	None	-	23	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	10.1038/s41467-023-40064-9
	43815	186896	64	None	-1995	25	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186896	64	None	-1995	25	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186896	64	None	-1995	25	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	1353	1898	93	None	-295	86	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	1898	93	None	-295	86	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	1898	93	None	-295	86	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	1898	93	None	-295	86	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	1898	93	None	-295	86	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2247	504	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	249	504	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	2603	504	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	CHEMBL296419	504	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	DB00637	504	81	None	-4	42	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
	4034	55792	55	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	CHEMBL1623	55792	55	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
	43815	186896	64	None	-1995	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL1708	186896	64	None	-1995	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	CHEMBL490	186896	64	None	-1995	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	10.1038/s41467-023-40064-9
	2435	3563	83	None	-2	49	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	60149	3563	83	None	-2	49	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	98	3563	83	None	-2	49	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	CHEMBL12713	3563	83	None	-2	49	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	DB06144	3563	83	None	-2	49	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1038/s41467-023-40064-9
	1830	2572	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	2572	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	2572	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	2572	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	2572	44	None	-	28	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	2393	3309	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	5078	3309	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	51	3309	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	CHEMBL905	3309	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	DB00953	3309	82	None	-	5	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	269	5	1	4	1.9	CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C	10.1038/s41467-023-40064-9
	1605	2327	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	3957	2327	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	7216	2327	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	CHEMBL998	2327	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	DB00455	2327	117	None	-1	4	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	10.1038/s41467-023-40064-9
	228	444	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	444	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	444	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	444	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	444	28	None	-5	24	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	2865	4112	73	None	-12	54	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	4112	73	None	-12	54	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	4112	73	None	-12	54	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	4112	73	None	-12	54	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	4112	73	None	-12	54	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	3547	141348	71	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
	CHEMBL38380	141348	71	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
	CHEMBL541388	141348	71	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	291	2	1	4	1.2	O=S(=O)(c1cccc2cnccc12)N1CCCNCC1	10.1038/s41467-023-40064-9
	5210	33308	48	None	-123	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1200765	33308	48	None	-123	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	CHEMBL1419	33308	48	None	-123	4	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	10.1038/s41467-023-40064-9
	1343	1876	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	3519	1876	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	522	1876	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	CHEMBL862	1876	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	DB01018	1876	62	None	-14	9	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	10.1038/s41467-023-40064-9
	2402	3345	62	None	-9	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3345	62	None	-9	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3345	62	None	-9	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3345	62	None	-9	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3345	62	None	-9	25	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	1201549	594	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	594	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	594	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	594	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	594	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	594	24	None	-26	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	4199	98817	42	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL278819	98817	42	None	-	1	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	298	5	1	5	2.2	Cc1cc(-c2ccccc2)nnc1NCCN1CCOCC1	10.1038/s41467-023-40064-9
	5311507	194792	41	None	-	1	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	CHEMBL53904	194792	41	None	-	1	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	400	5	1	4	4.2	OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
	37	775	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	1	17	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	3158	56237	27	None	-389	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL1628227	56237	27	None	-389	20	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
	2543	3681	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5358	3681	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	54	3681	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL128	3681	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	DB00669	3681	68	None	-2818	32	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1038/s41467-023-40064-9
	5411	204010	89	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	CHEMBL698	204010	89	None	-	2	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	8	1	4	2.6	CCCCNc1ccc(C(=O)OCCN(C)C)cc1	10.1038/s41467-023-40064-9
	3658	4076	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	517	4076	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	5709	4076	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	CHEMBL312448	4076	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	DB06694	4076	53	None	-	8	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	244	2	1	2	3.1	Cc1cc(cc(c1CC1=NCCN1)C)C(C)(C)C	10.1038/s41467-023-40064-9
	1400	1944	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	3658	1944	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	7199	1944	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	91513	1944	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL896	1944	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00557	1944	70	None	-	3	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	374	8	1	4	3.1	OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	5329102	194703	86	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	CHEMBL535	194703	86	None	-	0	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
	1971	2846	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	2404	2846	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	4543	2846	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL445	2846	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	DB00540	2846	38	None	-4	30	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
	1613	2333	53	None	-	45	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	205	2333	53	None	-	45	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	3964	2333	53	None	-	45	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	CHEMBL831	2333	53	None	-	45	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	DB00408	2333	53	None	-	45	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
	2351	3261	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	2820	3261	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	5035	3261	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	CHEMBL81	3261	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	DB00481	3261	64	None	-7	21	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1038/s41467-023-40064-9
	1357	2468	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
	1672	2468	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
	224	2468	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
	896	2468	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
	CHEMBL45	2468	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
	DB01065	2468	139	None	-3890	9	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1038/s41467-023-40064-9
	119570	3137	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	2233	3137	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	953	3137	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	CHEMBL301265	3137	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	DB00413	3137	96	None	-7585	40	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	10.1038/s41467-023-40064-9
	176	397	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2157	397	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	2566	397	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	CHEMBL633	397	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	DB01118	397	66	None	-1	31	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	10.1038/s41467-023-40064-9
	240	941	43	None	-6	25	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	2769	941	43	None	-6	25	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	44279790	941	43	None	-6	25	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	660	941	43	None	-6	25	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL1729	941	43	None	-6	25	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	CHEMBL560739	941	43	None	-6	25	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	DB00604	941	43	None	-6	25	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1038/s41467-023-40064-9
	2284	3160	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	4926	3160	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	7281	3160	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL564	3160	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00420	3160	33	None	-16	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
	5280343	188251	124	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL1520590	188251	124	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	CHEMBL50	188251	124	None	-	32	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	10.1038/s41467-023-40064-9
	10831	116937	25	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL338667	116937	25	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	397	7	2	5	4.3	O=C(Nc1ccccc1)OCC(CN1CCCCC1)OC(=O)Nc1ccccc1	10.1038/s41467-023-40064-9
	68867	78144	38	None	-	0	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	CHEMBL2104523	78144	38	None	-	0	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	402	7	2	6	3.1	CCOc1cc(N)c([N+](=O)[O-])cc1C(=O)NC1CCN(CC2CC=CCC2)CC1	10.1038/s41467-023-40064-9
	134	2497	24	None	-2	68	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2497	24	None	-2	68	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2497	24	None	-2	68	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2497	24	None	-2	68	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2497	24	None	-2	68	Human	8.6	pAC50	=	8.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	2105	3032	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3032	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3032	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3032	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3032	37	None	-28	33	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	135409453	3744	41	None	2	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	3744	41	None	2	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	3744	41	None	2	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	20628	96519	28	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	CHEMBL26291	96519	28	None	-	0	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	6	1	5	3.7	CN(C)CCCNc1c2ccccc2nc2cccc([N+](=O)[O-])c12	10.1038/s41467-023-40064-9
	441074	19382	82	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19382	82	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	165193	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	2303	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	4946	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	564	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	62882	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	63	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	66366	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	91536	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL27	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	CHEMBL452861	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	DB00571	3165	68	None	-72	43	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	10.1038/s41467-023-40064-9
	135398745	2893	112	None	-5	66	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	2893	112	None	-5	66	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	2893	112	None	-5	66	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	2893	112	None	-5	66	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	103	4122	61	None	1	54	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	4122	61	None	1	54	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	4122	61	None	1	54	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	4122	61	None	1	54	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	4122	61	None	1	54	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5666	102965	35	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
	CHEMBL306700	102965	35	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	237	5	1	4	1.5	CCOc1ccccc1OCC1CNCCO1	10.1038/s41467-023-40064-9
	16362	3103	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	2172	3103	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	90	3103	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL1423	3103	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB01100	3103	71	None	-	30	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	4209	3141	75	None	-758	34	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	4893	3141	75	None	-758	34	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	503	3141	75	None	-758	34	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	5385	3141	75	None	-758	34	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	CHEMBL2	3141	75	None	-758	34	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	DB00457	3141	75	None	-758	34	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
	319	1312	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	321	1312	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	444031	1312	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	784	1312	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	CHEMBL1346	1312	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	DB00496	1312	44	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	426	7	1	3	4.0	NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2	10.1038/s41467-023-40064-9
	2402	3345	62	None	-9	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	5095	3345	62	None	-9	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	7295	3345	62	None	-9	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	CHEMBL589	3345	62	None	-9	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	DB00268	3345	62	None	-9	25	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1038/s41467-023-40064-9
	3316	31730	71	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	CHEMBL1405973	31730	71	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	221	7	1	2	2.7	CCCCCCOc1ccccc1C(N)=O	10.1038/s41467-023-40064-9
	216416	111554	48	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL328190	111554	48	None	-	0	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	413	6	1	3	5.7	Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
	2771	194994	74	None	1	27	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	1	27	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	1	27	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	2337	3232	77	None	-15	63	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	3232	77	None	-15	63	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	3232	77	None	-15	63	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	3232	77	None	-15	63	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	3232	77	None	-15	63	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	10007	14452	38	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1201269	14452	38	None	-	0	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	183	2	1	1	2.6	CC(C)(N)Cc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	150	2492	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2492	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2492	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2492	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2492	21	None	1	16	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	2771	194994	74	None	1	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL1200781	194994	74	None	1	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	CHEMBL549	194994	74	None	1	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
	2099	9275	55	None	-	1	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL1110	9275	55	None	-	1	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	10.1038/s41467-023-40064-9
	1782	2501	84	None	-3	23	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	241	2501	84	None	-3	23	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	4168	2501	84	None	-3	23	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	CHEMBL86	2501	84	None	-3	23	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	DB01233	2501	84	None	-3	23	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	10.1038/s41467-023-40064-9
	11626560	200914	94	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	CHEMBL601719	200914	94	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	449	5	2	6	5.0	C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl	10.1038/s41467-023-40064-9
	1427	2000	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	357	2000	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3696	2000	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL11	2000	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00458	2000	54	None	-	27	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	124087	1377	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	7157	1377	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	814	1377	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	CHEMBL1172	1377	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	DB00967	1377	114	None	-5	15	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
	1530	2169	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	3827	2169	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	7206	2169	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	CHEMBL534	2169	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	DB00920	2169	50	None	-19	21	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	10.1038/s41467-023-40064-9
	55645	84341	8	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	84341	8	None	-	0	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	11658860	2329	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	2941	2329	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	4374	2329	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	CHEMBL360328	2329	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	DB04871	2329	51	None	-1	3	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1038/s41467-023-40064-9
	48041	107054	46	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	CHEMBL315838	107054	46	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
	1209	1645	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1645	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1645	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1645	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1645	75	None	-199	32	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	134	2497	24	None	-2	68	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1775	2497	24	None	-2	68	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	9681	2497	24	None	-2	68	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	CHEMBL1065	2497	24	None	-2	68	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	DB00247	2497	24	None	-2	68	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
	1210	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	1213	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	2725	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	33036	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	4411	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	616	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	6976	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	716121	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	90475904	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1201353	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL1554789	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	CHEMBL505	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB01114	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	DB13679	915	51	None	-1380	21	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	10.1038/s41467-023-40064-9
	11693	1814	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	3494	1814	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	4302	1814	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	7459	1814	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201335	1814	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	DB00986	1814	16	None	-	5	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	1	3	2.5	O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C	10.1038/s41467-023-40064-9
	21722	17960	31	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	CHEMBL126224	17960	31	None	-	6	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	4	0	2	4.3	CN(C)CCCn1c2c(c3ccccc31)CCCCCC2	10.1038/s41467-023-40064-9
	242	469	124	None	-1	52	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	469	124	None	-1	52	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	469	124	None	-1	52	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	469	124	None	-1	52	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	469	124	None	-1	52	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	31101	726	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	726	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	726	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	726	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	726	40	None	-26	36	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	2162	41484	100	None	-	6	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	CHEMBL1491	41484	100	None	-	6	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
	3337	206344	27	None	-75	41	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	65801	206344	27	None	-75	41	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	66264	206344	27	None	-75	41	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	91452	206344	27	None	-75	41	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	CHEMBL87493	206344	27	None	-75	41	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	10.1038/s41467-023-40064-9
	3157	1458	71	None	-37	12	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	7170	1458	71	None	-37	12	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	954	1458	71	None	-37	12	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	CHEMBL707	1458	71	None	-37	12	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	DB00590	1458	71	None	-37	12	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
	10531	1408	21	None	-15	24	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-15	24	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-15	24	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-15	24	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-15	24	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	2142	3074	58	None	-43	37	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4920903	3074	58	None	-43	37	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	502	3074	58	None	-43	37	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	5775	3074	58	None	-43	37	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	CHEMBL597	3074	58	None	-43	37	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	DB00692	3074	58	None	-43	37	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	10.1038/s41467-023-40064-9
	4418	34192	85	None	-	7	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	CHEMBL142635	34192	85	None	-	7	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
	150	2492	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	2492	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	2492	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	2492	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	2492	21	None	1	16	Human	8.3	pAC50	=	8.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	2520	203985	70	None	-4	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1280	203985	70	None	-4	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL6966	203985	70	None	-4	12	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	123606	351	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	128	351	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	7110	351	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	CHEMBL1505	351	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	DB00918	351	70	None	-	3	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	335	6	1	3	2.2	CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C	10.1038/s41467-023-40064-9
	1209	1645	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	1645	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	1645	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	1645	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	1645	75	None	-199	32	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	1212	1649	50	None	-27	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	204	1649	50	None	-27	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	3372	1649	50	None	-27	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL726	1649	50	None	-27	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00623	1649	50	None	-27	66	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	16231	207486	57	None	-	17	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
	CHEMBL945	207486	57	None	-	17	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	10.1038/s41467-023-40064-9
	5360696	1394	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	6953	1394	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	842	1394	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	CHEMBL52440	1394	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	DB00514	1394	30	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	271	1	0	2	3.4	COc1ccc2c(c1)[C@@]13CCCC[C@@H]3[C@H](C2)N(CC1)C	10.1038/s41467-023-40064-9
	4452	2742	19	None	-208	19	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	983	2742	19	None	-208	19	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL20734	2742	19	None	-208	19	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	10.1038/s41467-023-40064-9
	10531	1408	21	None	-15	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	1408	21	None	-15	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	1408	21	None	-15	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	1408	21	None	-15	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	1408	21	None	-15	24	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	27447	59773	63	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	3	5	0.4	CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1	10.1038/s41467-023-40064-9
	6560168	59773	63	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	3	5	0.4	CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1	10.1038/s41467-023-40064-9
	CHEMBL1727	59773	63	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	347	4	3	5	0.4	CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1	10.1038/s41467-023-40064-9
	154257	178595	67	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	178595	67	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	2470	3626	50	None	-14125	60	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	3300	3626	50	None	-14125	60	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	5265	3626	50	None	-14125	60	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	99	3626	50	None	-14125	60	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL267930	3626	50	None	-14125	60	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1038/s41467-023-40064-9
	2600	3750	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	2608	3750	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	5405	3750	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	CHEMBL17157	3750	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	DB00342	3750	74	None	-1	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
	1224	1420	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	3100	1420	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	8980	1420	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	916	1420	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	CHEMBL657	1420	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	DB01075	1420	83	None	-6	13	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	10.1038/s41467-023-40064-9
	2286	3161	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	4927	3161	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	7282	3161	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	CHEMBL643	3161	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	DB01069	3161	51	None	-5	30	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
	2713	205248	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5353524	205248	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	5360566	205248	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	88536661	205248	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	9552079	205248	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL1330113	205248	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	CHEMBL790	205248	82	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	504	9	10	4	4.2	N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
	2389	3306	118	None	-66	68	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	3306	118	None	-66	68	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	3306	118	None	-66	68	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	3306	118	None	-66	68	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	3306	118	None	-66	68	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	3639	168422	106	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	1	3	5	-0.4	NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O	10.1038/s41467-023-40064-9
	CHEMBL435	168422	106	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	297	1	3	5	-0.4	NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O	10.1038/s41467-023-40064-9
	191	402	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	201	402	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	2170	402	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	CHEMBL1113	402	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	DB00543	402	98	None	-5	29	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
	135	2515	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	1796	2515	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	4184	2515	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL6437	2515	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	DB06148	2515	43	None	-3	58	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
	2780	110502	36	None	-	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	CHEMBL325109	110502	36	None	-	11	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1038/s41467-023-40064-9
	72093	35031	9	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL1433361	35031	9	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	CHEMBL2103773	35031	9	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	483	16	1	4	6.3	CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1	10.1038/s41467-023-40064-9
	4212	198656	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
	CHEMBL1417019	198656	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
	CHEMBL58	198656	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	444	12	8	10	-0.1	O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21	10.1038/s41467-023-40064-9
	4567	9916	34	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	CHEMBL114655	9916	34	None	-	0	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	299	7	3	3	3.4	CC(CCc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
	3062316	33545	121	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	CHEMBL1421	33545	121	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	487	7	3	9	3.3	Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1	10.1038/s41467-023-40064-9
	213	3824	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	2717	3824	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	5533	3824	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	CHEMBL621	3824	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	DB00656	3824	55	None	-5	44	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
	135398737	955	93	None	-2	92	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	955	93	None	-2	92	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	955	93	None	-2	92	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	955	93	None	-2	92	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	955	93	None	-2	92	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	2105	3032	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	3032	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	3032	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	3032	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	3032	37	None	-28	33	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	37	775	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	775	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	775	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	775	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	775	60	None	1	17	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	1234	189197	56	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL1256940	189197	56	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	CHEMBL51149	189197	56	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	484	14	0	7	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2cc(OC)c(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
	180	400	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	200	400	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	2160	400	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL629	400	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	DB00321	400	56	None	-35	40	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
	3152	188387	103	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	CHEMBL502	188387	103	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	379	6	0	4	4.4	COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2	10.1038/s41467-023-40064-9
	1890	2739	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	4449	2739	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	7247	2739	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	CHEMBL623	2739	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	DB01149	2739	49	None	-	16	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
	214	3831	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	3831	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	3831	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	3831	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	3831	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	3831	58	None	-	30	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	212	3777	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	3777	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	3777	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	3777	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	3777	47	None	-	25	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	102	4096	48	None	-93	50	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	4096	48	None	-93	50	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	4096	48	None	-93	50	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	4096	48	None	-93	50	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	4096	48	None	-93	50	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	198	312	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	82148	312	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	99	312	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	CHEMBL10878	312	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	DB06594	312	126	None	-346	6	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1038/s41467-023-40064-9
	8249	59375	65	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1528839	59375	65	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL170988	59375	65	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	205	3	5	2	0.2	N=C(N)NC(=N)NCCc1ccccc1	10.1038/s41467-023-40064-9
	1222	878	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	2678	878	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	581	878	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1000	878	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	DB00341	878	0	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	388	8	1	4	3.1	OC(=O)COCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1	10.1038/s41467-023-40064-9
	1016	3720	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2561	3720	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	2733526	3720	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	5384	3720	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL83	3720	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	DB00675	3720	78	None	-17	35	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	10.1038/s41467-023-40064-9
	3686	94638	108	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	338	12	1	5	3.5	COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O	10.1038/s41467-023-40064-9
	CHEMBL252556	94638	108	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	338	12	1	5	3.5	COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O	10.1038/s41467-023-40064-9
	6989	100925	115	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	150	1	1	1	2.8	Cc1ccc(C(C)C)c(O)c1	10.1038/s41467-023-40064-9
	CHEMBL29411	100925	115	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	150	1	1	1	2.8	Cc1ccc(C(C)C)c(O)c1	10.1038/s41467-023-40064-9
	4886	14078	28	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1198	14078	28	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	293	9	0	4	3.0	CCCCOc1ccc(OCCCN2CCOCC2)cc1	10.1038/s41467-023-40064-9
	2318	154832	29	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL400599	154832	29	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	351	7	1	3	4.1	CC(Cc1cccc(C(F)(F)F)c1)NCCOC(=O)c1ccccc1	10.1038/s41467-023-40064-9
	2726	916	68	None	-19	73	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	621	916	68	None	-19	73	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	83	916	68	None	-19	73	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL71	916	68	None	-19	73	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB00477	916	68	None	-19	73	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	441074	19382	82	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	CHEMBL1294	19382	82	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human HTR2B in an in vitro assay with cellular components measured by membrane filtration	ChEMBL	324	4	1	4	3.2	C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](O)c1ccnc2ccc(OC)cc12	10.1038/s41467-023-40064-9
	10198431	73876	0	None	-7	3	Human	9.0	pEC50	=	9.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201930	73876	0	None	-7	3	Human	9.0	pEC50	=	9.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	5	139	72	None	-13	55	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	5202	139	72	None	-13	55	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	CHEMBL39	139	72	None	-13	55	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	DB08839	139	72	None	-13	55	Human	8.8	pEC50	=	8.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	44407335	73065	0	None	-7	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL201117	73065	0	None	-7	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	44407440	139281	0	None	-4	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL379223	139281	0	None	-4	3	Human	6.9	pEC50	=	6.9	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	18715554	74395	0	None	-10	3	Human	6.8	pEC50	=	6.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202656	74395	0	None	-10	3	Human	6.8	pEC50	=	6.8	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	18715564	73351	0	None	-7	3	Human	8.7	pEC50	=	8.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201454	73351	0	None	-7	3	Human	8.7	pEC50	=	8.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	18715555	74346	0	None	-8	3	Human	7.7	pEC50	=	7.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	CHEMBL202458	74346	0	None	-8	3	Human	7.7	pEC50	=	7.7	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	135398737	955	93	None	-2	92	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	955	93	None	-2	92	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	955	93	None	-2	92	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	955	93	None	-2	92	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	955	93	None	-2	92	Human	7.7	pEC50	=	7.7	Binding	Inverse agonist activity at human 5HT2B receptor by R-SAT assayInverse agonist activity at human 5HT2B receptor by R-SAT assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	44407398	74389	0	None	-8	3	Human	7.6	pEC50	=	7.6	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	CHEMBL202616	74389	0	None	-8	3	Human	7.6	pEC50	=	7.6	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	5	139	72	None	-29	55	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	5202	139	72	None	-29	55	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	CHEMBL39	139	72	None	-29	55	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	DB08839	139	72	None	-29	55	Rat	8.4	pEC50	=	8.4	Binding	Agonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secsAgonist activity at 5HT2b receptor in Wistar rat fundus measured for 90 secs	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.ejmech.2015.08.051
	166	3334	18	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	3045227	3334	18	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	CHEMBL76781	3334	18	None	1	3	Human	8.4	pEC50	=	8.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	44407453	74374	0	None	-9	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	CHEMBL202538	74374	0	None	-9	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	18715561	73015	0	None	-4	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201062	73015	0	None	-4	3	Human	7.4	pEC50	=	7.4	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	44407327	141222	0	None	-5	3	Human	6.3	pEC50	=	6.3	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL383042	141222	0	None	-5	3	Human	6.3	pEC50	=	6.3	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	18715558	73853	0	None	-5	3	Human	7.2	pEC50	=	7.2	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201897	73853	0	None	-5	3	Human	7.2	pEC50	=	7.2	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	9901086	187607	33	None	-	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm5019274
	CHEMBL494947	187607	33	None	-	2	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at 5HT2B receptor (unknown origin) relative to controlAgonist activity at 5HT2B receptor (unknown origin) relative to control	ChEMBL	304	4	1	5	2.1	Clc1cccc(COc2cncc(N3CCNCC3)n2)c1	10.1021/jm5019274
	44407337	74175	0	None	-5	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202324	74175	0	None	-5	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	44407460	140325	0	None	-6	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	CHEMBL380763	140325	0	None	-6	3	Human	7.0	pEC50	=	7.0	Binding	Binding to human 5HT2B receptor expressed in CHO cellsBinding to human 5HT2B receptor expressed in CHO cells	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	CHEMBL5081637	214734	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CN(CCc1cn(C)c2cccc(O)c12)CC1CC1	10.1021/acsmedchemlett.1c00578
	133	2479	52	None	-2	43	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	1723	2479	52	None	-2	43	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	28693	2479	52	None	-2	43	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	CHEMBL19215	2479	52	None	-2	43	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	DB13520	2479	52	None	-2	43	Human	9.4	pIC50	=	9.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	134	2497	24	None	-2	68	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	1775	2497	24	None	-2	68	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	9681	2497	24	None	-2	68	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	CHEMBL1065	2497	24	None	-2	68	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	DB00247	2497	24	None	-2	68	Human	9.3	pIC50	=	9.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	11291	3196	26	None	-	5	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
	4980	3196	26	None	-	5	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
	CHEMBL65547	3196	26	None	-	5	Human	9.0	pIC50	=	9.0	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	10.1021/acsmedchemlett.1c00578
	150	2492	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	1764	2492	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	8226	2492	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	CHEMBL1201356	2492	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	DB00353	2492	21	None	1	16	Human	8.8	pIC50	=	8.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	191	402	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	402	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	402	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	402	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	402	98	None	-5	29	Human	8.0	pIC50	=	8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2099	9275	55	None	-	1	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL1110	9275	55	None	-	1	Human	7.0	pIC50	=	7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	11518143	89037	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
	CHEMBL2322611	89037	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
	CHEMBL2365004	89037	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	454	12	1	5	4.0	COCCCOc1cc(C(=O)N(C[C@@H]2CNC[C@H]2Cc2ccccc2)C(C)C)ccc1OC	10.1021/jm3017078
	2274	3151	58	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3151	58	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3151	58	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3151	58	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3151	58	None	-10	32	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	25060119	104288	0	None	-9332	7	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	CHEMBL3099899	104288	0	None	-9332	7	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	3033538	1307	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	7155	1307	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	781	1307	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	CHEMBL1201216	1307	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	DB00298	1307	39	None	-12	9	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	213	3824	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	2717	3824	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	5533	3824	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	CHEMBL621	3824	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	DB00656	3824	55	None	-5	44	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	12488	1644	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	941361	1644	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	CHEMBL30008	1644	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	DB04841	1644	56	None	-11	23	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	135398737	955	93	None	-2	92	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	955	93	None	-2	92	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	955	93	None	-2	92	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	955	93	None	-2	92	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	955	93	None	-2	92	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	73453	29585	24	None	-9	17	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	CHEMBL1385840	29585	24	None	-9	17	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	25070577	111639	4	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	CHEMBL3286557	111639	4	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	304	3	2	4	2.3	CNc1nc(C(F)(F)c2ccccc2)nc2c1CCNCC2	10.1021/jm5003292
	240	941	43	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	2769	941	43	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	44279790	941	43	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	660	941	43	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL1729	941	43	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL560739	941	43	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	DB00604	941	43	None	-6	25	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	146159245	188426	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	451415	188426	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	86289437	188426	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	CHEMBL502620	188426	30	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	1224	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1420	83	None	-6	13	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	4178	195780	63	None	-	1	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	CHEMBL558	195780	63	None	-	1	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	44190762	176856	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
	CHEMBL461571	176856	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of radioligand from 5HT2B receptorDisplacement of radioligand from 5HT2B receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
	222757	99348	73	None	-1	3	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	CHEMBL282575	99348	73	None	-1	3	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	2812	4747	101	None	-40	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4747	101	None	-40	34	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	2247	504	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-4	42	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	23027035	198524	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
	CHEMBL578170	198524	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1ccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)cc1	10.1016/j.bmcl.2009.09.003
	78319901	159210	35	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2BSelectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2B	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
	CHEMBL4098877	159210	35	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Selectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2BSelectivity interaction (Enzymatic assay (PanLabs Profiling)) EUB0000715a HTR2B	ChEMBL	379	4	1	6	3.6	C[C@@H]1CN(c2cc(-c3n[nH]c4ccc(OC5(C)CC5)cc34)ncn2)C[C@H](C)O1	10.6019/CHEMBL5212743
	54764239	68837	0	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922537	68837	0	None	-	1	Human	4.9	pIC50	=	4.9	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	2726	916	68	None	-19	73	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-19	73	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-19	73	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-19	73	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-19	73	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	76072441	153923	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	7	0	4	3.4	C=CCN1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	CHEMBL3983539	153923	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	7	0	4	3.4	C=CCN1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	100	3776	58	None	-11	56	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3776	58	None	-11	56	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3776	58	None	-11	56	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3776	58	None	-11	56	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3776	58	None	-11	56	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	134551	357	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	271	357	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	885	357	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	CHEMBL1403281	357	27	None	-6	21	Human	7.9	pIC50	=	7.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	23027211	197227	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
	CHEMBL568400	197227	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	421	5	2	5	4.3	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)CC2)n1	10.1016/j.bmcl.2009.09.003
	100951644	169610	16	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	411	7	2	9	2.3	CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1	10.1021/acs.jmedchem.9b00260
	CHEMBL4437106	169610	16	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	411	7	2	9	2.3	CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(c3cccnn3)C2)s1)c1ccccc1	10.1021/acs.jmedchem.9b00260
	3042	1402	35	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1402	35	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1402	35	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1402	35	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1402	35	None	-39	15	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	5591	157507	90	None	1	2	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	CHEMBL408	157507	90	None	1	2	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	3168	9230	92	None	-107	22	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	CHEMBL1108	9230	92	None	-107	22	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	127048333	140655	1	None	38	3	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815112	140655	1	None	38	3	Human	6.9	pIC50	=	6.9	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	1971	2846	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2846	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2846	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2846	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2846	38	None	-4	30	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	1548953	207656	27	None	-4	17	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	207656	27	None	-4	17	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	5870	31630	92	None	-	1	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	CHEMBL1405	31630	92	None	-	1	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	6319	23443	95	None	-	1	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	CHEMBL1333512	23443	95	None	-	1	Human	6.9	pIC50	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	1305	510	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	9934033	510	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL182150	510	14	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	121318543	177543	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	560	6	0	6	4.7	COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2Cl)C1	10.1016/j.bmcl.2020.127214
	CHEMBL4640428	177543	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5-HT2B (unknown origin)Inhibition of 5-HT2B (unknown origin)	ChEMBL	560	6	0	6	4.7	COc1c(S(C)(=O)=O)ccc(O[C@@H](C)C(F)(F)F)c1C(=O)N1CC(c2ncc(C(F)(F)F)cc2Cl)C1	10.1016/j.bmcl.2020.127214
	16665072	98510	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	449	8	1	6	3.6	CN(C)CCN(C)c1nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc2n1C	10.1016/j.bmcl.2006.11.092
	CHEMBL276393	98510	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	449	8	1	6	3.6	CN(C)CCN(C)c1nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc2n1C	10.1016/j.bmcl.2006.11.092
	155558726	174784	0	None	-19	4	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL4562303	174784	0	None	-19	4	Human	4.8	pIC50	=	4.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	667590	67765	12	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909048	67765	12	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	44112	121264	48	None	-11	7	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	CHEMBL357995	121264	48	None	-11	7	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	17683252	67767	3	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909051	67767	3	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	155565189	175541	0	None	-6	4	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	CHEMBL4579120	175541	0	None	-6	4	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	3525815	74117	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	CHEMBL2022867	74117	3	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	2520	203985	70	None	-4	12	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL1280	203985	70	None	-4	12	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL6966	203985	70	None	-4	12	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	23027245	197105	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
	CHEMBL567791	197105	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cc(N(C)C)nc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)n1	10.1016/j.bmcl.2009.09.003
	10660	14384	58	None	-29	12	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14384	58	None	-29	12	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	2333	142310	97	None	1	2	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	CHEMBL388590	142310	97	None	1	2	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	2771	194994	74	None	1	27	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL1200781	194994	74	None	1	27	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL549	194994	74	None	1	27	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	104903	56314	17	None	-4	6	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	CHEMBL1630578	56314	17	None	-4	6	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	2723	154022	108	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	CHEMBL398440	154022	108	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	1379258	67766	13	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909050	67766	13	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	76072442	146363	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	407	5	0	4	4.0	CC(C)(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	CHEMBL3921628	146363	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	407	5	0	4	4.0	CC(C)(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	11277147	106314	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092759	106314	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139188	106314	0	None	9	2	Human	7.7	pIC50	=	7.7	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	76072471	153513	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	405	6	0	4	3.8	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCC1	nan
	CHEMBL3980023	153513	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	405	6	0	4	3.8	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCC1	nan
	11452268	81544	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	396	5	1	5	4.2	Cc1nc(N2CCCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2006.11.092
	CHEMBL216228	81544	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of 5HT2BInhibition of 5HT2B	ChEMBL	396	5	1	5	4.2	Cc1nc(N2CCCC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2006.11.092
	11957541	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	1229	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	147	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	170617	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	CHEMBL6616	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cellsDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.03.006
	11957541	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	1229	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	147	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	170617	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	CHEMBL6616	1446	40	None	-2	16	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]DOI from human recombinant 5HT2B receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2016.11.014
	9881053	120219	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [3H]5-HT from 5-hydroxytryptamine 2B receptorAbility to displace [3H]5-HT from 5-hydroxytryptamine 2B receptor	ChEMBL	339	5	1	4	4.1	CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1	10.1021/jm020954v
	CHEMBL35226	120219	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [3H]5-HT from 5-hydroxytryptamine 2B receptorAbility to displace [3H]5-HT from 5-hydroxytryptamine 2B receptor	ChEMBL	339	5	1	4	4.1	CCCN1CCC(COc2nc3ccccc3c3c2CCCN3)CC1	10.1021/jm020954v
	1201549	594	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	594	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	594	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	594	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	594	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	594	24	None	-26	20	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	5510	205829	100	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	CHEMBL83668	205829	100	None	-	1	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	44393396	127271	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.6	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3cccc(Cl)c3Cl)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL365882	127271	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.6	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3cccc(Cl)c3Cl)cc12	10.1016/j.bmcl.2004.05.051
	4122	207602	108	None	-3	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	CHEMBL9514	207602	108	None	-3	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	1353	1898	93	None	-295	86	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	3559	1898	93	None	-295	86	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	86	1898	93	None	-295	86	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL54	1898	93	None	-295	86	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	DB00502	1898	93	None	-295	86	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	1016	3720	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-17	35	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL1909069	209053	0	None	-1	3	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL		None	None	None		None	nan
	1343	1876	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	3519	1876	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	522	1876	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	CHEMBL862	1876	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	DB01018	1876	62	None	-14	9	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	2337	3232	77	None	-15	63	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3232	77	None	-15	63	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3232	77	None	-15	63	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3232	77	None	-15	63	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3232	77	None	-15	63	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	122196341	124247	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	CHEMBL3634745	124247	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at human 5HT2bAntagonist activity at human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	2585	800	103	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	522	800	103	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	551	800	103	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	CHEMBL723	800	103	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	DB01136	800	103	None	-18	22	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	2389	3306	118	None	-66	68	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	5073	3306	118	None	-66	68	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	96	3306	118	None	-66	68	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	CHEMBL85	3306	118	None	-66	68	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	DB00734	3306	118	None	-66	68	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	2398	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	951	62	None	-3	29	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	1605	2327	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	3957	2327	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	7216	2327	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	CHEMBL998	2327	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	DB00455	2327	117	None	-1	4	Human	6.6	pIC50	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	45482789	198902	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
	CHEMBL584554	198902	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
	122185011	122538	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	339	3	0	3	5.0	COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC	10.1039/C4MD00113C
	CHEMBL3601563	122538	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	339	3	0	3	5.0	COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC	10.1039/C4MD00113C
	11080	29054	79	None	-6	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	CHEMBL1381098	29054	79	None	-6	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	3151	1450	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	945	1450	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	965	1450	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	CHEMBL219916	1450	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	DB01184	1450	97	None	-125	27	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	5818	3764	47	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
	5886965	3764	47	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
	CHEMBL1368005	3764	47	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	10.1021/jm401431x
	76072440	149326	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	393	6	0	4	3.6	CC(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	CHEMBL3945224	149326	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	393	6	0	4	3.6	CC(C)N1CC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)OC1=O	nan
	1227	2472	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	2331	2472	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	3957	2472	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	4992	2472	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	CHEMBL511	2472	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	DB06691	2472	43	None	-112	12	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	42636941	178925	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	CHEMBL470432	178925	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	5	0	5	4.4	CCCN1CCC(COc2nc3scc(C)c3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	1524	2168	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	197	2168	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	3822	2168	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	88	2168	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	CHEMBL51	2168	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	DB12465	2168	96	None	-229	52	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	119584	2577	102	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	1848	2577	102	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	242	2577	102	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	CHEMBL60889	2577	102	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	DB11675	2577	102	None	1	6	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	76072443	151554	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	6	0	4	3.4	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CC1	nan
	CHEMBL3963333	151554	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	391	6	0	4	3.4	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CC1	nan
	11957541	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	1229	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	147	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	170617	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	CHEMBL6616	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.bmc.2013.03.016
	11957541	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	1229	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	147	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	170617	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	CHEMBL6616	1446	40	None	-2	16	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	72548703	161543	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysisDisplacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161543	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysisDisplacement of [125I]+/-DOI from human recombinant 5-HT2B receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	1043	1569	14	None	-22	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	149	1569	14	None	-22	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	8223	1569	14	None	-22	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL442	1569	14	None	-22	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00696	1569	14	None	-22	29	Human	8.5	pIC50	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	23027527	196769	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL565551	196769	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	371	5	2	5	3.1	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(F)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	23027411	198497	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL577912	198497	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	387	5	2	5	3.7	Cc1cnc(N[C@H]2CC[C@@H](NC(=O)c3ccc(Cl)cc3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	5318	15544	49	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1200348	15544	49	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1221	15544	49	None	-1	13	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	1531	2253	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	3869	2253	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	7207	2253	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	CHEMBL429	2253	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	DB00598	2253	69	None	-16	16	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	124	2960	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	2032	2960	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	4636	2960	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	CHEMBL762	2960	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	DB00935	2960	47	None	-181	33	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	45485062	197145	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
	CHEMBL567993	197145	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	367	5	2	5	3.3	Cc1cccc(C(=O)N[C@H]2CC[C@@H](Nc3ncc(C)c(N(C)C)n3)CC2)c1	10.1016/j.bmcl.2009.09.003
	44404883	72033	32	None	-2	4	Human	7.5	pIC50	=	7.5	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	CHEMBL197664	72033	32	None	-2	4	Human	7.5	pIC50	=	7.5	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	15987265	196864	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL566075	196864	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	503	6	2	5	5.3	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	3191	102831	97	None	-7	25	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102831	97	None	-7	25	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	448537	160226	89	None	-21	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	CHEMBL411	160226	89	None	-21	25	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	5897	105184	80	None	-1	3	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	CHEMBL311469	105184	80	None	-1	3	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	72197486	102476	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393245	102476	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040361	102476	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	364	4	2	4	4.2	Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1	10.1016/j.ejmech.2013.02.020
	45484995	198496	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL577904	198496	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]rauwolsine from human 5HT2B receptorDisplacement of [3H]rauwolsine from human 5HT2B receptor	ChEMBL	403	6	2	5	3.5	Cc1cnc(N[C@H]2CC[C@@H](CNC(=O)c3ccc(F)c(F)c3)CC2)nc1N(C)C	10.1016/j.bmcl.2009.09.003
	127048335	140567	1	None	15	3	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813726	140567	1	None	15	3	Human	6.5	pIC50	=	6.5	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	196129	67769	17	None	-26	15	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	CHEMBL1909065	67769	17	None	-26	15	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	4011	82379	49	None	-20	24	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82379	49	None	-20	24	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	4601	206724	35	None	-4	17	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	206724	35	None	-4	17	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	206724	35	None	-4	17	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	68617	205504	62	None	-15	26	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205504	62	None	-15	26	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205504	62	None	-15	26	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	165193	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3165	68	None	-72	43	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2353	101085	82	None	-7	5	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL12089	101085	82	None	-7	5	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL295124	101085	82	None	-7	5	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	3117	207818	103	None	-8	16	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	207818	103	None	-8	16	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	2284	3160	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3160	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3160	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3160	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3160	33	None	-16	29	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	11304816	66249	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	424	5	1	5	4.0	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL184717	66249	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	424	5	1	5	4.0	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(Cl)cc3)cc12	10.1016/j.bmcl.2004.05.051
	11536844	115096	0	None	1	2	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	115096	0	None	1	2	Human	7.5	pIC50	=	7.5	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	2351	3261	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	2820	3261	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	5035	3261	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	CHEMBL81	3261	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	DB00481	3261	64	None	-7	21	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	444795	139974	105	None	3	2	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	CHEMBL38	139974	105	None	3	2	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	26987	946	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	6063	946	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	671	946	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	CHEMBL1626	946	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	DB00283	946	33	None	-47	21	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	72734860	103930	0	None	6	5	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092753	103930	0	None	6	5	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysisAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells coexpressing EBNA assessed as inhibition of 5-HT-induced IP metabolism incubated for 20 mins prior to substrate addition measured after 20 mins by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	3973	208157	110	None	-44	3	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	CHEMBL98350	208157	110	None	-44	3	Human	4.4	pIC50	=	4.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	3157	1458	71	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	7170	1458	71	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	954	1458	71	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	CHEMBL707	1458	71	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	DB00590	1458	71	None	-37	12	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	58438464	3043	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3043	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3043	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3043	35	None	-	3	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	6726	1269	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1269	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1269	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1269	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1269	51	None	-7	13	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	118112300	155970	18	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at 5HT2B (unknown origin)Antagonist activity at 5HT2B (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
	CHEMBL4061793	155970	18	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at 5HT2B (unknown origin)Antagonist activity at 5HT2B (unknown origin)	ChEMBL	430	6	2	6	3.8	O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F	10.1016/j.bmcl.2017.03.085
	2142	3074	58	None	-43	37	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	4920903	3074	58	None	-43	37	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	502	3074	58	None	-43	37	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	5775	3074	58	None	-43	37	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	CHEMBL597	3074	58	None	-43	37	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	DB00692	3074	58	None	-43	37	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	1212	1649	50	None	-27	66	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1649	50	None	-27	66	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1649	50	None	-27	66	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1649	50	None	-27	66	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1649	50	None	-27	66	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	11957541	1446	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	1229	1446	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	147	1446	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	170617	1446	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	CHEMBL6616	1446	40	None	-2	16	Human	8.4	pIC50	=	8.4	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	1042	1568	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	148	1568	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	443884	1568	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	CHEMBL119443	1568	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	DB01253	1568	23	None	-7	17	Human	8.4	pIC50	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	44393215	66633	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	417	6	2	4	5.4	Cc1cc(NC(C)C)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL185376	66633	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	417	6	2	4	5.4	Cc1cc(NC(C)C)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	78243717	137325	53	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Selectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2BSelectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2B	ChEMBL	321	4	1	5	2.4	O=C(/C=C/N1C[C@H]2C[C@@H]1CN2c1ccccn1)c1ccccc1O	10.6019/CHEMBL5212743
	CHEMBL3752911	137325	53	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Selectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2BSelectivity interaction (CEREP panel (cellular receptors and 30 other enzymes)) EUB0000199c HTR2B	ChEMBL	321	4	1	5	2.4	O=C(/C=C/N1C[C@H]2C[C@@H]1CN2c1ccccn1)c1ccccc1O	10.6019/CHEMBL5212743
	74538762	143516	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	419	6	0	4	4.2	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCCC1	nan
	CHEMBL3898995	143516	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.Radiolabel Binding Assay: A solution of the compound of the disclosure to be tested is prepared as a 1-mg/ml stock in Assay Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) or DMSO according to its solubility. A 1-mg/ml stock of the reference compound 5-hydroxytryptamine (5-HT) is also prepared as a positive control. Eleven dilutions (5x assay concentration) of the compound of the disclosure and 5-HT are prepared in the Assay Buffer by serial dilution to yield final corresponding assay concentrations ranging from 10 uM to 10 uM.A stock concentration of 5 nM [3H]LSD (lysergic acid diethyl amide) is prepared in Assay Buffer. Aliquots (50 ul) of radioligand are dispensed into the wells of a 96-well plate containing 100 ul of Assay Buffer. Duplicate 50-ul aliquots of the compound of the disclosure test and 5-HT positive control reference compound serial dilutions are added. Membrane fractions of cells expressing recombinant 5HT2B receptors (50 uL) are dispensed into each well. The membranes are prepared from stably transfected c ell lines expressing 5HT2B receptors cultured on 10-cm plates by harvesting PBS-rinsed monolayers, resuspending and lysing the monolayers in chilled, hypotonic 50 mM Tris-HCl, pH 7.4, centrifuging at 20,000xg, decanting the supernatant and storing at -80° C. The membrane preparations are resuspended in 3 ml of chilled Assay Buffer and homogenized by several passages through a 26 gauge needle before use in the assay.	ChEMBL	419	6	0	4	4.2	O=C1OC(CN2CCN(C(c3ccccc3)c3ccccc3)CC2)CN1C1CCCC1	nan
	1599	2326	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	3955	2326	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	7215	2326	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	CHEMBL841	2326	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	DB00836	2326	50	None	-144	16	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	165193	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3165	68	None	-72	43	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4209	3141	75	None	-758	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	4893	3141	75	None	-758	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	503	3141	75	None	-758	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	5385	3141	75	None	-758	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	CHEMBL2	3141	75	None	-758	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	DB00457	3141	75	None	-758	34	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	CHEMBL5079070	214581	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CC(C)N(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	124087	1377	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1377	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1377	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1377	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1377	114	None	-5	15	Human	7.4	pIC50	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	72198754	90851	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	CHEMBL2392349	90851	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	443	8	0	4	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	58438475	92244	0	None	-	2	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	CHEMBL2426677	92244	0	None	-	2	Human	5.4	pIC50	=	5.4	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	21138	98423	39	None	-6	7	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	CHEMBL275742	98423	39	None	-6	7	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	10389430	125925	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.3	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	CHEMBL364863	125925	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human 5-HT2B receptorInhibitory activity against human 5-HT2B receptor	ChEMBL	458	5	1	5	4.3	Cc1cc(N2CCN(C)CC2)nc2ccc(NC(=O)COc3ccc(C(F)(F)F)cc3)cc12	10.1016/j.bmcl.2004.05.051
	1530	2169	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2169	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2169	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2169	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2169	50	None	-19	21	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	5353853	17954	47	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	9556529	17954	47	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1262	17954	47	None	-23	15	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	2600	3750	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	2608	3750	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	5405	3750	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	CHEMBL17157	3750	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	DB00342	3750	74	None	-1	13	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	4211	57792	83	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	CHEMBL1670	57792	83	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	6761	67770	19	None	-7	18	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	CHEMBL1909072	67770	19	None	-7	18	Human	7.3	pIC50	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	1588	2311	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	28864	2311	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	43	2311	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	CHEMBL157138	2311	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	DB00589	2311	27	None	-6	44	Human	8.3	pIC50	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	206	2476	16	None	-1	25	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	68848	2476	16	None	-1	25	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL12314	2476	16	None	-1	25	Human	8.3	pIC50	=	8.3	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	44516817	57633	5	None	-4365	2	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	CHEMBL1668584	57633	5	None	-4365	2	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorDisplacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptor	ChEMBL	316	3	1	6	2.2	CNc1nn2c(C)cc(C)nc2c1S(=O)(=O)c1ccccc1	10.1016/j.ejmech.2011.01.038
	6075	150084	42	None	-8	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	150084	42	None	-8	16	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	5624	32663	14	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL1203324	32663	14	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL141343	32663	14	None	5	10	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	11694810	120513	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120513	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120513	0	None	1	3	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation countingInhibition of human 5-HT2B receptor expressed in HEK293-EBNA cells assessed as [3H]PI metabolism by by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	44592109	179063	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	6	0	5	4.4	CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	CHEMBL471663	179063	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	343	6	0	5	4.4	CCCCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	56645363	121464	12	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	Selectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2BSelectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
	CHEMBL3582478	121464	12	None	-2	4	Human	5.3	pIC50	=	5.3	Binding	Selectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2BSelectivity interaction (Enzyme panel (Eurofins-Panlabs radioligand binding assays)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
	169713	80132	20	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	CHEMBL21343	80132	20	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	309	3	2	2	2.6	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1	10.1016/j.bmcl.2009.09.002
	4943	193393	105	None	1	2	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	CHEMBL526	193393	105	None	1	2	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	11500509	120555	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120555	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120555	0	None	-3	3	Human	7.3	pIC50	=	7.3	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	4189	206899	96	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-26	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	2683	102861	25	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102861	25	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102861	25	None	-501	16	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	3598	187797	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	CHEMBL496	187797	76	None	-2	7	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	135398745	2893	112	None	-5	66	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	47	2893	112	None	-5	66	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	CHEMBL715	2893	112	None	-5	66	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	DB00334	2893	112	None	-5	66	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	107715	200922	22	None	-14	20	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL1255837	200922	22	None	-14	20	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL601773	200922	22	None	-14	20	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	122196341	124247	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to human 5HT2bBinding affinity to human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	CHEMBL3634745	124247	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to human 5HT2bBinding affinity to human 5HT2b	ChEMBL	422	5	1	3	6.0	O=c1ccc(-c2ccc(OCc3ccc4ccccc4n3)cc2)c(-c2ccc(F)cc2)[nH]1	10.1021/acs.jmedchem.5b01240
	10531	1408	21	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	121	1408	21	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	888	1408	21	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL1732	1408	21	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00320	1408	21	None	-15	24	Human	8.2	pIC50	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	1836	2574	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	3340	2574	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	5281040	2574	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	CHEMBL787	2574	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	DB00471	2574	59	None	-69	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	14049689	198420	11	None	20	2	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	CHEMBL577294	198420	11	None	20	2	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	72198756	90853	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	478	8	0	5	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3c(Cl)nc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	CHEMBL2392351	90853	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	478	8	0	5	4.8	COc1ccccc1N1CCN(CCCCCN2Cc3c(Cl)nc4ccccc4c3C2=O)CC1	10.1016/j.ejmech.2013.01.044
	1782	2501	84	None	-3	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	241	2501	84	None	-3	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	4168	2501	84	None	-3	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	CHEMBL86	2501	84	None	-3	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	DB01233	2501	84	None	-3	23	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	72713752	103716	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	396	5	2	7	3.0	Cc1csc(C(C)(O)c2nnc(NC(=O)Cc3c(F)cccc3F)s2)n1	10.1021/jm4012033
	CHEMBL3088176	103716	0	None	-	0	Human	4.2	pIC50	=	4.2	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	396	5	2	7	3.0	Cc1csc(C(C)(O)c2nnc(NC(=O)Cc3c(F)cccc3F)s2)n1	10.1021/jm4012033
	90644511	111638	18	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
	CHEMBL3286556	111638	18	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	282	3	2	4	2.4	CNc1nc(Cc2ccccc2)nc2c1CCNC[C@@H]2C	10.1021/jm5003292
	2406	100376	89	None	-27	12	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	CHEMBL290106	100376	89	None	-27	12	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	2286	3161	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3161	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3161	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3161	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3161	51	None	-5	30	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	3198	205490	76	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-30	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	135	2515	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2515	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2515	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2515	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2515	43	None	-3	58	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	180	400	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	400	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	400	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	400	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	400	56	None	-35	40	Human	7.2	pIC50	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	4595	176691	106	None	2	15	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL46	176691	106	None	2	15	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	11536843	115097	0	None	1	2	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	115097	0	None	1	2	Human	7.1	pIC50	=	7.1	Binding	Antagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolismAntagonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as [3H]PI metabolism	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	1547484	937	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	654	937	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	9072	937	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL43064	937	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB00568	937	74	None	-8	20	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	102	4096	48	None	-93	50	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	3659	4096	48	None	-93	50	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	8969	4096	48	None	-93	50	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	CHEMBL15245	4096	48	None	-93	50	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	DB01392	4096	48	None	-93	50	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	2477	742	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	36	742	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	437	742	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	CHEMBL49	742	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	DB00490	742	59	None	-13	29	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	71499384	111122	41	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	448	8	1	5	4.5	COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OC	10.1021/jm401431x
	CHEMBL3264204	111122	41	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	448	8	1	5	4.5	COc1cc(/C=C/C(=O)NCCn2c(C(F)(F)F)cc3ccccc32)cc(OC)c1OC	10.1021/jm401431x
	2105	3032	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	47811	3032	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	48	3032	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	CHEMBL531	3032	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	DB01186	3032	37	None	-28	33	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	67406727	117166	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394201	117166	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	11957735	199998	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	CHEMBL595449	199998	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	350	4	1	5	4.0	CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1	10.1016/j.bmc.2009.07.007
	2028	2958	80	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2958	80	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2958	80	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2958	80	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2958	80	None	-40	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	31101	726	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	35	726	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	403	726	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	CHEMBL493	726	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	DB01200	726	40	None	-26	36	Human	8.1	pIC50	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	161	751	6	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	4284720	751	6	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	CHEMBL1255834	751	6	None	2	6	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	54764240	68839	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922539	68839	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL5085055	214923	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Modulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assayModulation of human 5HT2B expressed in HEK293T cells co-transfected with Galphaq-RLuc8, Ggamma1-GFP2 and Gbeta1 assessed as dissociation of Galphaq from Ggamma1 preincubated for 1 hr followed by addition of coelenterazine 400a substrate and measured after 15 mins by BRET assay	ChEMBL		None	None	None		CCN(C)CCc1cn(C)c2cccc(O)c12	10.1021/acsmedchemlett.1c00578
	4098	32475	30	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32475	30	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32475	30	None	-14	11	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	54764241	68838	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922538	68838	0	None	-	1	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	5282379	194961	69	None	1	3	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	CHEMBL547	194961	69	None	1	3	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	146420029	184738	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	379	3	1	3	4.2	CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1	10.1016/j.ejmech.2021.113782
	CHEMBL4851044	184738	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	379	3	1	3	4.2	CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1	10.1016/j.ejmech.2021.113782
	3158	56237	27	None	-389	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56237	27	None	-389	20	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	72197484	102467	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL2393243	102467	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	CHEMBL3040324	102467	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-lysergic acid from human recombinant 5HT-2B receptorDisplacement of [3H]-lysergic acid from human recombinant 5HT-2B receptor	ChEMBL	330	4	2	4	3.5	c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1	10.1016/j.ejmech.2013.02.020
	277	1289	62	None	-5	46	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1289	62	None	-5	46	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1289	62	None	-5	46	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1289	62	None	-5	46	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1289	62	None	-5	46	Human	8.0	pIC50	=	8.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	1305	510	14	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	9934033	510	14	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	CHEMBL182150	510	14	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]LSD from human 5HT2B receptorDisplacement of [125I]LSD from human 5HT2B receptor	ChEMBL	425	5	2	5	4.1	O=C(c1ccc(c(c1)F)F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C	10.1016/j.bmcl.2009.09.003
	9861687	189175	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	315	4	0	5	3.7	CCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	CHEMBL511312	189175	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptorDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor	ChEMBL	315	4	0	5	3.7	CCN1CCC(COc2nc3ccsc3n3cccc23)CC1	10.1016/j.bmc.2008.11.045
	2291	3162	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	2561	3162	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	4932	3162	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	CHEMBL631	3162	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	DB01182	3162	58	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	176	397	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-1	31	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	657255	199061	34	None	-9	15	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	CHEMBL588119	199061	34	None	-9	15	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	3952	1875	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5353646	1875	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5443	1875	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5702063	1875	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL1331786	1875	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL420	1875	38	None	-3	12	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	24360	203321	106	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	CHEMBL65	203321	106	None	-	1	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	127048334	140575	1	None	13	3	Human	7.0	pIC50	=	7	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813796	140575	1	None	13	3	Human	7.0	pIC50	=	7	Binding	Antagonist activity at human 5-HT2B receptor by PDSP assayAntagonist activity at human 5-HT2B receptor by PDSP assay	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	10851262	40529	0	None	1	2	Rat	8.9	pKd	=	8.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	293	1	1	3	3.7	Cc1coc2cc3c(cc12)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL148346	40529	0	None	1	2	Rat	8.9	pKd	=	8.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	293	1	1	3	3.7	Cc1coc2cc3c(cc12)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	9972439	40581	0	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	2	1	3	3.7	CCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL148385	40581	0	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	2	1	3	3.7	CCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	10851406	119238	1	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	295	1	1	3	3.9	O=C(Nc1cccnc1)N1CCc2cc3sccc3cc21	10.1021/jm960571v
	CHEMBL343666	119238	1	None	-1	2	Rat	8.0	pKd	=	8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	295	1	1	3	3.9	O=C(Nc1cccnc1)N1CCc2cc3sccc3cc21	10.1021/jm960571v
	141	1415	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	6089	1415	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	CHEMBL12420	1415	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	DB01488	1415	35	None	-11	22	Rat	6.0	pKd	=	6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm00343a013
	12281266	31802	5	None	-	1	Rat	7.0	pKd	=	7.0	Binding	Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.	ChEMBL	187	3	0	1	3.7	CC(C)CCn1ccc2ccccc21	10.1021/jm00367a008
	CHEMBL140663	31802	5	None	-	1	Rat	7.0	pKd	=	7.0	Binding	Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.Compound was tested for serotonin receptor affinity by the displacement of [3H]- -5-HT binding to rat fundus membranes.	ChEMBL	187	3	0	1	3.7	CC(C)CCn1ccc2ccccc21	10.1021/jm00367a008
	6088	119816	56	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1021/jm00343a013
	CHEMBL348588	119816	56	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	174	3	2	1	1.9	CNCCc1c[nH]c2ccccc12	10.1021/jm00343a013
	10637557	36241	0	None	5	2	Rat	7.9	pKd	=	7.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	294	1	1	3	2.7	CN1CCc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL144567	36241	0	None	5	2	Rat	7.9	pKd	=	7.9	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	294	1	1	3	2.7	CN1CCc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	152234	55993	22	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1cccc(CC(C)N)c1	10.1021/jm00144a009
	CHEMBL16247	55993	22	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1cccc(CC(C)N)c1	10.1021/jm00144a009
	44359526	116605	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2c(ccn2CCC(C)C)c1	10.1021/jm00367a008
	CHEMBL336928	116605	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2c(ccn2CCC(C)C)c1	10.1021/jm00367a008
	44359525	28840	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	CHEMBL137933	28840	1	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	805647	30780	12	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	189	3	0	3	1.6	CN(C)CCn1cnc2ccccc21	10.1021/jm00367a008
	CHEMBL139655	30780	12	None	-	1	Rat	6.9	pKd	=	6.9	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	189	3	0	3	1.6	CN(C)CCn1cnc2ccccc21	10.1021/jm00367a008
	143435	99666	6	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(CC(C)N)cc1OC	10.1021/jm00144a009
	CHEMBL284589	99666	6	None	-	1	Rat	5.9	pKd	=	5.9	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(CC(C)N)cc1OC	10.1021/jm00144a009
	62787	206165	21	None	-3	10	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	10.1021/jm00144a009
	CHEMBL8642	206165	21	None	-3	10	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	10.1021/jm00144a009
	9904139	106966	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm960571v
	CHEMBL315223	106966	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm960571v
	31014	205868	20	None	2	3	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(OC)cc1CC(C)N	10.1021/jm00144a009
	CHEMBL8389	205868	20	None	2	3	Rat	6.8	pKd	=	6.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(OC)cc1CC(C)N	10.1021/jm00144a009
	144891	107360	8	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	241	5	1	4	2.3	COc1cc(OC)c(SC)cc1CC(C)N	10.1021/jm00144a009
	CHEMBL31787	107360	8	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	241	5	1	4	2.3	COc1cc(OC)c(SC)cc1CC(C)N	10.1021/jm00144a009
	9904139	106966	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm00014a004
	CHEMBL315223	106966	1	None	1	4	Rat	7.8	pKd	=	7.8	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CC3	10.1021/jm00014a004
	141685	107021	6	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(CC(C)N)cc1OC	10.1021/jm00144a009
	CHEMBL31557	107021	6	None	-	1	Rat	5.8	pKd	=	5.8	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(CC(C)N)cc1OC	10.1021/jm00144a009
	11806221	120196	1	None	-	1	Rat	6.7	pKd	=	6.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)C(CCN(C)C)CN2	10.1021/jm00343a013
	CHEMBL352140	120196	1	None	-	1	Rat	6.7	pKd	=	6.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)C(CCN(C)C)CN2	10.1021/jm00343a013
	10757038	119208	0	None	1	2	Rat	7.7	pKd	=	7.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	1	1	3	3.5	Cc1cc2cc3c(cc2n1C)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL343455	119208	0	None	1	2	Rat	7.7	pKd	=	7.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	306	1	1	3	3.5	Cc1cc2cc3c(cc2n1C)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	10690384	120930	0	None	-3	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	368	3	1	3	4.7	O=C(Nc1cccnc1)N1CCc2cc3c(ccn3Cc3ccccc3)cc21	10.1021/jm960571v
	CHEMBL356146	120930	0	None	-3	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	368	3	1	3	4.7	O=C(Nc1cccnc1)N1CCc2cc3c(ccn3Cc3ccccc3)cc21	10.1021/jm960571v
	44359444	29098	0	None	-	1	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	CHEMBL138144	29098	0	None	-	1	Rat	7.7	pKd	=	7.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	217	4	0	2	3.7	COc1ccc2ccn(CCC(C)C)c2c1	10.1021/jm00367a008
	12655251	119283	58	None	-	1	Rat	5.7	pKd	=	5.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	162	2	2	2	1.5	NCCC1CNc2ccccc21	10.1021/jm00367a008
	CHEMBL344028	119283	58	None	-	1	Rat	5.7	pKd	=	5.7	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	162	2	2	2	1.5	NCCC1CNc2ccccc21	10.1021/jm00367a008
	11074217	52777	4	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	190	3	1	2	2.1	CN(C)CCC1CNc2ccccc21	10.1021/jm00343a013
	CHEMBL159503	52777	4	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	190	3	1	2	2.1	CN(C)CCC1CNc2ccccc21	10.1021/jm00343a013
	547452	54761	2	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	187	3	0	1	2.6	CN(C)CCC1=CCc2ccccc21	10.1021/jm00343a013
	CHEMBL161241	54761	2	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	187	3	0	1	2.6	CN(C)CCC1=CCc2ccccc21	10.1021/jm00343a013
	12451869	55154	5	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL161751	55154	5	None	-	1	Rat	5.7	pKd	=	5.7	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	144889	99296	6	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(OC)c(CC(C)N)cc1C	10.1021/jm00144a009
	CHEMBL282183	99296	6	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(OC)c(CC(C)N)cc1C	10.1021/jm00144a009
	34677	102192	88	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	147	0	1	1	1.5	NC1CCc2ccccc2C1	10.1021/jm00343a013
	CHEMBL30294	102192	88	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	147	0	1	1	1.5	NC1CCc2ccccc2C1	10.1021/jm00343a013
	141047	99378	20	None	1	3	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)c(OC)c1	10.1021/jm00144a009
	CHEMBL282734	99378	20	None	1	3	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)c(OC)c1	10.1021/jm00144a009
	31016	102260	15	None	-11	5	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	10.1021/jm00144a009
	CHEMBL30336	102260	15	None	-11	5	Rat	5.6	pKd	=	5.6	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	10.1021/jm00144a009
	15011362	52616	24	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	161	2	1	1	2.1	NCCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL159346	52616	24	None	-	1	Rat	5.6	pKd	=	5.6	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	161	2	1	1	2.1	NCCC1CCc2ccccc21	10.1021/jm00343a013
	744368	164905	18	None	-	1	Rat	6.6	pKd	=	6.6	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	190	3	0	2	1.6	CN(C)CCN1CCc2ccccc21	10.1021/jm00367a008
	CHEMBL422471	164905	18	None	-	1	Rat	6.6	pKd	=	6.6	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	190	3	0	2	1.6	CN(C)CCN1CCc2ccccc21	10.1021/jm00367a008
	159755	57065	61	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccccc1CC(C)N	10.1021/jm00144a009
	CHEMBL16451	57065	61	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccccc1CC(C)N	10.1021/jm00144a009
	91255	99083	11	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(CC(C)N)c1OC	10.1021/jm00144a009
	CHEMBL280855	99083	11	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(CC(C)N)c1OC	10.1021/jm00144a009
	189	3466	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
	5163	3466	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
	CHEMBL297784	3466	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm960571v
	189	3466	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
	5163	3466	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
	CHEMBL297784	3466	39	None	2	17	Rat	8.5	pKd	=	8.5	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm00014a004
	10683987	121252	1	None	3	2	Rat	7.5	pKd	=	7.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	278	1	2	2	3.2	O=C(Nc1cccnc1)N1CCc2cc3[nH]ccc3cc21	10.1021/jm960571v
	CHEMBL357870	121252	1	None	3	2	Rat	7.5	pKd	=	7.5	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	278	1	2	2	3.2	O=C(Nc1cccnc1)N1CCc2cc3[nH]ccc3cc21	10.1021/jm960571v
	1614	203632	24	None	-2	10	Rat	6.5	pKd	=	6.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	10.1021/jm00144a009
	CHEMBL6731	203632	24	None	-2	10	Rat	6.5	pKd	=	6.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	10.1021/jm00144a009
	8423	98661	30	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)cc1OC	10.1021/jm00144a009
	CHEMBL277540	98661	30	None	-	1	Rat	5.5	pKd	=	5.5	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1ccc(CC(C)N)cc1OC	10.1021/jm00144a009
	126769	206019	42	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
	CHEMBL536255	206019	42	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
	CHEMBL85194	206019	42	None	-1	5	Rat	7.4	pKd	=	7.4	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1021/jm00014a004
	12451869	55154	5	None	-	1	Rat	5.4	pKd	=	5.4	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL161751	55154	5	None	-	1	Rat	5.4	pKd	=	5.4	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	175	3	1	1	2.3	CNCCC1CCc2ccccc21	10.1021/jm00343a013
	155	725	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	163	725	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	62065	725	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	CHEMBL6607	725	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	DB01484	725	25	None	-10	13	Rat	7.4	pKd	=	7.4	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	10.1021/jm00144a009
	44375004	52976	1	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	189	3	0	1	2.7	CN(C)CCC1CCc2ccccc21	10.1021/jm00343a013
	CHEMBL159689	52976	1	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	189	3	0	1	2.7	CN(C)CCC1CCc2ccccc21	10.1021/jm00343a013
	44359477	116408	0	None	-	1	Rat	7.3	pKd	=	7.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2ccn(CCC(C)C)c12	10.1021/jm00367a008
	CHEMBL336042	116408	0	None	-	1	Rat	7.3	pKd	=	7.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2ccn(CCC(C)C)c12	10.1021/jm00367a008
	77042	188333	58	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	177	4	0	2	1.8	CN(C)CCC(=O)c1ccccc1	10.1021/jm00343a013
	CHEMBL50115	188333	58	None	-	1	Rat	5.3	pKd	=	5.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	177	4	0	2	1.8	CN(C)CCC(=O)c1ccccc1	10.1021/jm00343a013
	31015	118389	16	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(CC(C)N)c(OC)c1	10.1021/jm00144a009
	CHEMBL34108	118389	16	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1cc(OC)c(CC(C)N)c(OC)c1	10.1021/jm00144a009
	10335310	205980	0	None	75	2	Rat	7.3	pKd	=	7.3	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2cc3c(cc21)CCCN3C(=O)Nc1cccnc1	10.1021/jm00014a004
	CHEMBL84888	205980	0	None	75	2	Rat	7.3	pKd	=	7.3	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2cc3c(cc21)CCCN3C(=O)Nc1cccnc1	10.1021/jm00014a004
	33984	29610	40	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	192	5	0	2	2.1	CCN(CCN(C)C)c1ccccc1	10.1021/jm00367a008
	CHEMBL138604	29610	40	None	-	1	Rat	6.3	pKd	=	6.3	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	192	5	0	2	2.1	CCN(CCN(C)C)c1ccccc1	10.1021/jm00367a008
	1150	3849	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	125	3849	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	CHEMBL6640	3849	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	DB08653	3849	121	None	-8	25	Rat	6.3	pKd	=	6.3	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	10.1021/jm00343a013
	3007	155661	27	None	-1	6	Rat	5.3	pKd	=	5.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	ChEMBL	135	2	1	1	1.6	CC(N)Cc1ccccc1	10.1021/jm00144a009
	CHEMBL405	155661	27	None	-1	6	Rat	5.3	pKd	=	5.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	ChEMBL	135	2	1	1	1.6	CC(N)Cc1ccccc1	10.1021/jm00144a009
	127035062	136426	0	None	-4	19	Human	6.3	pKd	=	6.3	Binding	Non-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot methodNon-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	136426	0	None	-4	19	Human	6.3	pKd	=	6.3	Binding	Non-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot methodNon-competitive antagonist activity at human recombinant 5-HT2B receptor stably expressed in HEK cell membrane by schild plot method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	10591799	39920	0	None	1	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	2	1	3	4.2	CC(C)n1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL147820	39920	0	None	1	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	2	1	3	4.2	CC(C)n1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	44363813	40530	0	None	19	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	305	1	1	2	4.1	Cc1cn(C)c2cc3c(cc12)N(C(=O)Nc1ccccc1)CC3	10.1021/jm960571v
	CHEMBL148347	40530	0	None	19	2	Rat	8.2	pKd	=	8.2	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	305	1	1	2	4.1	Cc1cn(C)c2cc3c(cc12)N(C(=O)Nc1ccccc1)CC3	10.1021/jm960571v
	10335309	206023	0	None	-	1	Rat	7.2	pKd	=	7.2	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CCC3	10.1021/jm00014a004
	CHEMBL85247	206023	0	None	-	1	Rat	7.2	pKd	=	7.2	Binding	Inhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptorInhibitory potency against rat stomach fundus 5-hydroxytryptamine 2B receptor	ChEMBL	306	1	1	3	3.6	Cn1ccc2c3c(ccc21)N(C(=O)Nc1cccnc1)CCC3	10.1021/jm00014a004
	31721	98794	42	None	-	1	Rat	5.2	pKd	=	5.2	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccc(CC(C)N)cc1	10.1021/jm00144a009
	CHEMBL278663	98794	42	None	-	1	Rat	5.2	pKd	=	5.2	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	165	3	1	2	1.6	COc1ccc(CC(C)N)cc1	10.1021/jm00144a009
	10495940	78829	0	None	1	2	Rat	8.1	pKd	=	8.1	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	3	1	3	4.0	CCCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	CHEMBL2112859	78829	0	None	1	2	Rat	8.1	pKd	=	8.1	Binding	Inhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundusInhibition of 5-HT binding to 5-HT2B receptor of Rat stomach fundus	ChEMBL	320	3	1	3	4.0	CCCn1ccc2cc3c(cc21)CCN3C(=O)Nc1cccnc1	10.1021/jm960571v
	44359524	28838	1	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2c1ccn2CCC(C)C	10.1021/jm00367a008
	CHEMBL137932	28838	1	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	201	3	0	1	4.0	Cc1cccc2c1ccn2CCC(C)C	10.1021/jm00367a008
	164	1448	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	85875	1448	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	CHEMBL8600	1448	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	DB01528	1448	19	None	-3	10	Rat	7.1	pKd	=	7.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	10.1021/jm00144a009
	141048	102842	9	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(OC)c1CC(C)N	10.1021/jm00144a009
	CHEMBL30577	102842	9	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	195	4	1	3	1.6	COc1cccc(OC)c1CC(C)N	10.1021/jm00144a009
	25187	100271	28	None	-	1	Rat	5.1	pKd	=	5.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	163	4	0	1	2.2	CN(C)CCCc1ccccc1	10.1021/jm00343a013
	CHEMBL289199	100271	28	None	-	1	Rat	5.1	pKd	=	5.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	163	4	0	1	2.2	CN(C)CCCc1ccccc1	10.1021/jm00343a013
	44359556	119402	0	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)NCC2CCN(C)C	10.1021/jm00367a008
	CHEMBL344878	119402	0	None	-	1	Rat	7.1	pKd	=	7.1	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	220	4	1	3	2.2	COc1ccc2c(c1)NCC2CCN(C)C	10.1021/jm00367a008
	145	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	1832	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	CHEMBL7257	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	DB14010	140	49	None	-16	30	Rat	7.1	pKd	=	7.1	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm00343a013
	31012	103091	17	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1ccc(CC(C)N)c(OC)c1OC	10.1021/jm00144a009
	CHEMBL30777	103091	17	None	-	1	Rat	5.1	pKd	=	5.1	Binding	Affinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundusAffinity against 5-hydroxytryptamine 2B receptor in the isolated rat stomach fundus	ChEMBL	225	5	1	4	1.6	COc1ccc(CC(C)N)c(OC)c1OC	10.1021/jm00144a009
	81206	29619	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00367a008
	CHEMBL138614	29619	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranesDisplacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00367a008
	81206	29619	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00343a013
	CHEMBL138614	29619	37	None	-	1	Rat	6.0	pKd	=	6.0	Binding	The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundusThe binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus	ChEMBL	164	4	1	2	1.7	CN(C)CCNc1ccccc1	10.1021/jm00343a013
	CHEMBL5270056	193593	0	None	100	2	Rat	10.1	pKi	=	10.1	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	428	4	2	3	5.0	COc1ccc(CC2NCCc3c2[nH]c2c(C)c(C)ccc32)c(Br)c1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL5277645	193917	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	368	5	2	4	4.3	COc1ccc(CC2NCCc3c2[nH]c2cccc(SC)c32)cc1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL5279881	194018	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	5	2	3	4.2	CCc1cccc2[nH]c3c(c12)CCNC3Cc1ccc(OC)c(OC)c1	10.1021/acs.jmedchem.0c01887
	CHEMBL5280131	194029	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	448	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2cccc(I)c32)cc1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL5284094	194220	0	None	-	1	Rat	10.0	pKi	=	10	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	336	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2cccc(C)c32)cc1OC	10.1021/acs.jmedchem.0c01887
	11666595	120506	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310115	120506	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545467	120506	0	None	301	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1c(Cl)cccc1-2	10.1016/j.bmc.2014.05.027
	9839057	41364	4	None	-9	3	Human	9.7	pKi	=	9.7	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	293	2	1	3	3.8	CC(N)Cc1c2ccoc2c(Br)c2ccoc12	10.1021/jm9803525
	CHEMBL149024	41364	4	None	-9	3	Human	9.7	pKi	=	9.7	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	293	2	1	3	3.8	CC(N)Cc1c2ccoc2c(Br)c2ccoc12	10.1021/jm9803525
	9953185	207596	4	None	1	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human 5-HT2B assessed as inhibition constantBinding affinity to human 5-HT2B assessed as inhibition constant	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.2c00633
	CHEMBL95121	207596	4	None	1	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human 5-HT2B assessed as inhibition constantBinding affinity to human 5-HT2B assessed as inhibition constant	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.2c00633
	10597927	207508	0	None	93	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	414	4	2	3	4.7	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Br)c1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL94644	207508	0	None	93	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	414	4	2	3	4.7	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Br)c1OC	10.1021/acs.jmedchem.0c01887
	10618362	207511	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	358	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2c(F)cc(F)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL94655	207511	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	358	4	2	3	3.9	COc1ccc(CC2NCCc3c2[nH]c2c(F)cc(F)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
	9953185	207596	4	None	-1	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL95121	207596	4	None	-1	3	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	370	4	2	3	4.6	COc1ccc(CC2NCCc3c2[nH]c2ccc(C)cc32)c(Cl)c1OC	10.1021/acs.jmedchem.0c01887
	10760338	207823	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2c(C)cc(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL96427	207823	0	None	-	1	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2c(C)cc(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
	10569875	207839	0	None	15	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2cc(C)c(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
	CHEMBL96480	207839	0	None	15	2	Rat	9.7	pKi	=	9.7	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	350	4	2	3	4.2	COc1ccc(CC2NCCc3c2[nH]c2cc(C)c(C)cc32)cc1OC	10.1021/acs.jmedchem.0c01887
	133	2479	52	None	-2	43	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	1723	2479	52	None	-2	43	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	28693	2479	52	None	-2	43	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	CHEMBL19215	2479	52	None	-2	43	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	DB13520	2479	52	None	-2	43	Human	9.6	pKi	=	9.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
	188	3366	80	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
	196968	3366	80	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
	CHEMBL473186	3366	80	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant	ChEMBL	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10.1021/acs.jmedchem.2c00633
	70772974	191465	6	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysisBinding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysis	ChEMBL	369	3	2	3	3.8	Cc1c(C(=O)N2CCC(c3ncc[nH]3)CC2)n[nH]c1-c1ccc(Cl)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL5193649	191465	6	None	-	1	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysisBinding affinity to human 5-HT2B assessed as inhibition constant in microplate beta scintillation counter analysis	ChEMBL	369	3	2	3	3.8	Cc1c(C(=O)N2CCC(c3ncc[nH]3)CC2)n[nH]c1-c1ccc(Cl)cc1	10.1021/acs.jmedchem.2c00633
	134	2497	24	None	-2	68	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	1775	2497	24	None	-2	68	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	9681	2497	24	None	-2	68	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	CHEMBL1065	2497	24	None	-2	68	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	DB00247	2497	24	None	-2	68	Human	9.5	pKi	=	9.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
	242	469	124	None	-1	52	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	34	469	124	None	-1	52	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	60795	469	124	None	-1	52	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	CHEMBL1112	469	124	None	-1	52	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	DB01238	469	124	None	-1	52	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2016.05.053
	11393666	192962	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5201983	192962	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	CHEMBL5222597	192962	0	None	1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
	11978813	718	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	5014	718	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	7672	718	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	CHEMBL2105760	718	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	DB09128	718	79	None	-2	24	Human	9.4	pKi	=	9.4	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	10.1016/j.ejmech.2019.111736
	11465618	102371	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL3039528	102371	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	CHEMBL5191141	102371	23	None	-1	19	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
	10686579	112336	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	312	2	2	1	4.8	c1ccc2c(CC3NCCc4c3[nH]c3ccccc43)cccc2c1	10.1021/acs.jmedchem.0c01887
	CHEMBL329479	112336	0	None	-	1	Rat	9.4	pKi	=	9.4	Binding	Displacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysisDisplacement of [3H]-ketanserin from rat 5-HT2B expressed in mouse NIH/3T3 cells assessed as inhibition constant by Cheng-Prusoff equation analysis	ChEMBL	312	2	2	1	4.8	c1ccc2c(CC3NCCc4c3[nH]c3ccccc43)cccc2c1	10.1021/acs.jmedchem.0c01887
	23151734	103931	0	None	467	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092758	103931	0	None	467	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	265	1	2	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(=O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	11687730	120559	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343668	120559	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545816	120559	0	None	9	2	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	277	1	2	1	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	71528206	86942	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323581	86942	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	314	3	0	4	2.8	COC(OC)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	56597938	3909	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
	7651	3909	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
	CHEMBL2165126	3909	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm300603y
	56597090	81954	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	7	0	4	6.6	Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl	10.1021/jm300603y
	CHEMBL2165137	81954	0	None	-1	5	Human	9.2	pKi	=	9.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	7	0	4	6.6	Clc1cccc(C2CCN(CCCCOc3ccc4scnc4c3)CC2)c1Cl	10.1021/jm300603y
	56597938	3909	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	7651	3909	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL2165126	3909	3	None	2	9	Human	9.2	pKi	=	9.2	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	118706290	120507	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310116	120507	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545468	120507	0	None	128	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1C(O)c1cc(C(=O)N=C(N)N)ccc1-2	10.1016/j.bmc.2014.05.027
	118706734	120500	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310714	120500	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545444	120500	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	309	2	3	2	1.9	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	150	2492	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	1764	2492	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	8226	2492	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	CHEMBL1201356	2492	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	DB00353	2492	21	None	1	16	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1021/jm100600y
	118706282	120504	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310111	120504	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545465	120504	0	None	17	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.5	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	118706299	120511	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310121	120511	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545472	120511	0	None	64	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	269	1	3	2	2.3	N=C(N)NC(=O)c1ccc2c(c1)C(F)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	118706284	120498	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310112	120498	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545440	120498	0	None	31	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	285	1	3	2	1.3	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(F)c1-2	10.1016/j.bmc.2014.05.027
	150	2492	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	1764	2492	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	8226	2492	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	CHEMBL1201356	2492	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	DB00353	2492	21	None	1	16	Human	9.0	pKi	=	9.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
	71528205	86941	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323580	86941	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	368	5	1	4	2.2	CN(C)CCCNC(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	71528204	86940	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL2323579	86940	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	439	6	1	5	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4c3c(cn4C)C[C@H]2N(C)C1	10.1021/ml3003814
	11358099	180382	0	None	3	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4752099	180382	0	None	3	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	3	1	4	2.8	COc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	11460460	182338	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784845	182338	0	None	-1	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.5	CC(C)n1nc2c(c1-c1ccc(Cl)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	9954003	71671	24	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	CHEMBL196514	71671	24	None	-1	9	Human	9.0	pKi	=	9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	422	5	2	4	3.8	C[C@H]1Oc2c(cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)NC1=O	10.1021/jm070516u
	16062782	97805	0	None	2	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	307	2	1	3	3.8	Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL272082	97805	0	None	2	3	Human	9.0	pKi	=	9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	307	2	1	3	3.8	Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	59757163	106315	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092760	106315	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139189	106315	0	None	218	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	118706732	120501	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3310713	120501	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	CHEMBL3545445	120501	0	None	3	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	1	3	2	1.6	Cc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2(C)O	10.1016/j.bmc.2014.05.027
	56593482	3910	3	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	7650	3910	3	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL2165119	3910	3	None	1	9	Human	9.0	pKi	=	9.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
	10568771	102762	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL305275	102762	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL6710	102762	2	None	-5	5	Human	8.9	pKi	=	8.9	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]rauwolscine as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	242	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	34	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	60795	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	CHEMBL1112	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	DB01238	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm070516u
	11658860	2329	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	2941	2329	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	4374	2329	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	CHEMBL360328	2329	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	DB04871	2329	51	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2012.10.091
	37	775	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	460	775	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	54746	775	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	CHEMBL1201087	775	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	DB00248	775	60	None	1	17	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1021/ml3003814
	242	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	34	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	60795	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	CHEMBL1112	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	DB01238	469	124	None	-1	52	Human	8.9	pKi	=	8.9	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
	118706278	120497	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310109	120497	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545439	120497	0	None	26	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(Cl)c1-2	10.1016/j.bmc.2014.05.027
	2865	4112	73	None	-12	54	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	59	4112	73	None	-12	54	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	60854	4112	73	None	-12	54	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	CHEMBL708	4112	73	None	-12	54	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	DB00246	4112	73	None	-12	54	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm070516u
	9888211	21384	13	None	-1	10	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	CHEMBL131495	21384	13	None	-1	10	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	417	6	1	3	4.5	O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1	10.1021/jm070516u
	10568771	102762	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL305275	102762	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	CHEMBL6710	102762	2	None	-5	5	Human	8.8	pKi	=	8.8	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	297	2	1	3	2.2	C[C@@H](N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm980076u
	10017554	4309	29	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm9803525
	CHEMBL101008	4309	29	None	-1	4	Human	8.8	pKi	=	8.8	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	297	2	1	3	2.2	CC(N)Cc1c2c(c(Br)c3c1OCC3)OCC2	10.1021/jm9803525
	11957541	1446	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	1229	1446	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	147	1446	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	170617	1446	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	CHEMBL6616	1446	40	None	-2	16	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I](+/-)DOI from human recombinant 5-HT2B receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/acs.jmedchem.6b01422
	118706285	112861	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310113	112861	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	295	2	3	2	1.7	CCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	135399866	72026	2	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	CHEMBL197653	72026	2	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	209	2	2	4	1.2	C[C@H](N)Cn1ncc2ccc(O)c(F)c21	10.1021/jm050663x
	118464429	167093	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4290245	167093	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	383	1	3	5	2.6	NC1=NC2(CCCCC2)NC(Nc2cccc(I)c2)=N1	10.1021/acsmedchemlett.8b00300
	127048333	140655	1	None	38	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815112	140655	1	None	38	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccccc2F)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	118706280	120503	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310110	120503	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545464	120503	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cc(Cl)ccc1-2	10.1016/j.bmc.2014.05.027
	118717220	120554	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343669	120554	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545811	120554	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	305	1	2	1	2.9	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	72734860	103930	0	None	6	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092753	103930	0	None	6	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)Cc1ccccc1-2	10.1016/j.bmc.2013.10.010
	11277147	106314	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092759	106314	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139188	106314	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	11277147	106314	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3092759	106314	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3139188	106314	0	None	9	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	134	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	1775	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	9681	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	CHEMBL1065	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	DB00247	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.ejmech.2019.111736
	206	2476	16	None	-1	25	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
	68848	2476	16	None	-1	25	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
	CHEMBL12314	2476	16	None	-1	25	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/S0960-894X(96)00503-3
	192	3476	54	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
	443390	3476	54	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
	CHEMBL14276	3476	54	None	-10	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10.1021/jm990388c
	10573762	98755	0	None	1	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)cc1)CC2	10.1021/jm990388c
	CHEMBL278267	98755	0	None	1	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)cc1)CC2	10.1021/jm990388c
	10670813	162567	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	4	1	3	5.9	CCc1cc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc(-c2cccnc2)c1	10.1021/jm990388c
	CHEMBL416896	162567	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	4	1	3	5.9	CCc1cc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc(-c2cccnc2)c1	10.1021/jm990388c
	44397929	67151	0	None	-6	3	Human	8.0	pKi	=	8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL187739	67151	0	None	-6	3	Human	8.0	pKi	=	8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	10808965	100303	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	367	3	1	3	4.8	CCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL289436	100303	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	367	3	1	3	4.8	CCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	46230098	199306	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590580	199306	0	None	-3	3	Human	8.0	pKi	=	8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1cccc2c1C(=O)NC1CCNCCN21	10.1016/j.bmcl.2009.12.014
	18931422	207369	0	None	-50	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	435	8	2	5	3.4	COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL93862	207369	0	None	-50	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	435	8	2	5	3.4	COc1ccc(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	10740494	35109	0	None	-12	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14345	35109	0	None	-12	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10764263	40856	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	CHEMBL14863	40856	0	None	-15	3	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	10740495	98601	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)nc1)CC2	10.1021/jm990388c
	CHEMBL277111	98601	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	414	3	1	4	4.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3cccnc3)nc1)CC2	10.1021/jm990388c
	122178705	121345	0	None	2	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581250	121345	0	None	2	5	Human	8.0	pKi	=	8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	59395105	106313	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3092755	106313	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3139187	106313	1	None	4	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	252	1	3	1	1.7	NC(N)=NC(=O)c1ccc2c(c1)[nH]c1ccccc12	10.1016/j.bmc.2013.10.010
	118729272	120684	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402680	120684	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547158	120684	0	None	3	4	Human	8.0	pKi	=	8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	44214724	194963	0	None	-19	3	Human	8.0	pKi	=	8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cnccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL54707	194963	0	None	-19	3	Human	8.0	pKi	=	8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cnccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	5	139	72	None	-13	55	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	5202	139	72	None	-13	55	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	CHEMBL39	139	72	None	-13	55	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	DB08839	139	72	None	-13	55	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/acs.jmedchem.1c00726
	24841480	183875	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL481153	183875	0	None	-50	20	Human	7.0	pKi	=	7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	193	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	3644637	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	CHEMBL14563	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	194	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	443391	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	CHEMBL14460	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm990388c
	193	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	3644637	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	CHEMBL14563	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	194	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	443391	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	CHEMBL14460	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/j.bmcl.2005.08.004
	CHEMBL5285512	194276	0	None	1	3	Human	7.0	pKi	=	7	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	327	2	1	3	4.9	COc1ccc2[nH]c3c(-c4cn(C)c5ccccc45)nccc3c2c1	10.1021/acs.jmedchem.0c01887
	193	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	3644637	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	CHEMBL14563	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	194	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	443391	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	CHEMBL14460	3481	31	None	-100	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10.1016/s0960-894x(00)00364-4
	44298230	194579	0	None	-79	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	492	3	1	4	6.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL53152	194579	0	None	-79	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	492	3	1	4	6.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)c(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	44298022	195535	0	None	-63	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	5	1	4	5.8	CCCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55472	195535	0	None	-63	3	Human	7.0	pKi	=	7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	5	1	4	5.8	CCCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	18931133	168007	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	465	9	2	6	3.4	COc1cc(OC)c(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL432217	168007	0	None	-10	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	465	9	2	6	3.4	COc1cc(OC)c(-c2ccccc2)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	145977338	163693	0	None	19	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	CHEMBL4205064	163693	0	None	19	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	259	3	2	4	2.2	Oc1ccccc1C1=NC(Cc2c[nH]cn2)CS1	10.1021/acs.jnatprod.7b00317
	145963830	164099	0	None	7	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4209942	164099	0	None	7	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	335	4	2	4	4.0	Oc1ccccc1C1=NC(Cc2c[nH]cn2)C(c2ccccc2)S1	10.1021/acs.jnatprod.7b00317
	193	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
	3644637	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
	CHEMBL14563	3480	46	None	-707	4	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	10.1021/jm970424c
	11419526	88027	0	None	-100	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3ccc(Cl)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234533	88027	0	None	-100	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3ccc(Cl)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	16215237	88146	0	None	-39	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(Cl)c(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234738	88146	0	None	-39	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(Cl)c(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10503674	98797	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3c(F)cccc3F)c1)CC2	10.1021/jm990388c
	CHEMBL278685	98797	0	None	-3	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3c(F)cccc3F)c1)CC2	10.1021/jm990388c
	9813197	96506	6	None	-11	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	1	1	2.7	Clc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL262862	96506	6	None	-11	3	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	215	0	1	1	2.7	Clc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	25122651	200226	0	None	-23	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm901674f
	CHEMBL597002	200226	0	None	-23	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm901674f
	67268994	163944	2	None	-3	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4207884	163944	2	None	-3	7	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	247	1	2	2	2.4	Clc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	44298108	100897	0	None	-39	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL293937	100897	0	None	-39	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	44298092	101942	0	None	-19	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	400	4	1	5	4.7	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccs3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL301409	101942	0	None	-19	2	Human	7.0	pKi	=	7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	400	4	1	5	4.7	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccs3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	162663486	181975	0	None	-	1	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2cccc(C(F)(F)F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4780527	181975	0	None	-	1	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2cccc(C(F)(F)F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	162672422	183157	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	CHEMBL4795598	183157	0	None	-1	2	Human	6.0	pKi	=	6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	24888181	80095	0	None	-158	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL213272	80095	0	None	-158	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	24887525	80340	1	None	-199	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL214398	80340	1	None	-199	3	Human	6.0	pKi	=	6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(C)(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	9888494	98143	0	None	-446	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determinedBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determined	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	CHEMBL273921	98143	0	None	-446	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determinedBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor was determined	ChEMBL	422	4	1	5	3.6	O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3cc(F)ccc32)CC1	10.1016/s0960-894x(03)00077-5
	11168182	3508	25	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	264	3508	25	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	CHEMBL1181770	3508	25	None	-158	13	Human	6.0	pKi	=	6	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	511	14	1	3	6.5	CN(CCN(C(=O)CCC1CCCC1)Cc1ccc(cc1)c1ccc(cc1)CNCCc1ccccc1)C	10.1016/j.bmcl.2005.06.024
	6918648	101532	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL29846	101532	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1021/jm980532e
	145972374	164650	0	None	-3	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4216860	164650	0	None	-3	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	136054961	57289	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	CHEMBL1651091	57289	4	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	153287535	174876	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	0	1	3	2.0	CN1CC[C@H]2c3ccc(O)cc3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4564308	174876	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	0	1	3	2.0	CN1CC[C@H]2c3ccc(O)cc3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	23462894	157207	3	None	-15	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	240	1	0	3	2.3	CN1CCc2ccc([N+](=O)[O-])c(Cl)c2CC1	10.1016/j.bmc.2007.12.009
	CHEMBL407636	157207	3	None	-15	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	240	1	0	3	2.3	CN1CCc2ccc([N+](=O)[O-])c(Cl)c2CC1	10.1016/j.bmc.2007.12.009
	9934284	90267	0	None	-2511	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238520	90267	0	None	-2511	10	Human	6.0	pKi	=	6	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	1	5	4.5	Cc1ccc2c(OCCN3CCC(Cc4cc5c(cc4F)OCC(=O)N5)CC3)cc(F)cc2n1	10.1016/j.bmcl.2006.11.031
	76325517	105705	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	272	3	1	4	3.3	O=c1cc(CCc2cccs2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3126302	105705	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	272	3	1	4	3.3	O=c1cc(CCc2cccs2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	118278480	121985	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2ccc(O)cc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593950	121985	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2ccc(O)cc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	44453877	155592	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	305	2	1	3	3.6	Fc1ccc(-c2nc(-c3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL404582	155592	0	None	-19	3	Human	6.0	pKi	=	6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	305	2	1	3	3.6	Fc1ccc(-c2nc(-c3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	44298151	100838	0	None	-31	2	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Cl)ccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL293597	100838	0	None	-31	2	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Cl)ccc21	10.1016/s0960-894x(00)00365-6
	44298158	193950	0	None	-12	3	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2c(Cl)cccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL52783	193950	0	None	-12	3	Human	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	380	4	1	4	4.3	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2c(Cl)cccc21	10.1016/s0960-894x(00)00365-6
	6918648	101532	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	CHEMBL29846	101532	1	None	-1621	14	Human	6.0	pKi	=	6	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	465	5	1	6	4.4	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1	10.1016/s0960-894x(02)00172-5
	3233	3486	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	3247	3486	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	6604889	3486	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	CHEMBL282199	3486	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	DB13988	3486	44	None	-165	12	Human	5.0	pKi	=	5	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	352	5	1	4	2.7	CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O	10.1021/jm991151j
	16063047	95354	0	None	-77	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL256811	95354	0	None	-77	3	Human	5.0	pKi	=	5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCCC3)cc1	10.1016/j.bmcl.2008.01.090
	122483292	138086	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764335	138086	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765876	138086	0	None	-3	7	Human	7.0	pKi	=	7	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	1	5	5.5	O=C(CCCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	141	1415	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	6089	1415	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	CHEMBL12420	1415	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	DB01488	1415	35	None	-1	22	Human	7.0	pKi	=	7	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	10.1021/jm980692q
	136054961	57289	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/np100588c
	CHEMBL1651091	57289	4	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	220	2	2	4	1.6	NC(=O)c1csc(-c2ccccc2O)n1	10.1021/np100588c
	73213196	104433	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	CHEMBL3104093	104433	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2014.05.016
	73213196	104433	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	104433	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	73213196	104433	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104093	104433	4	None	1	13	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.9	CN1CCc2c(c3cccc4c3n2CCc2ccccc2-4)C1	10.1016/j.bmcl.2013.12.024
	142601343	185579	0	None	-36	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863868	185579	0	None	-36	7	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	71455083	81801	0	None	-173	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164354	81801	0	None	-173	7	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	389	6	0	3	4.8	O=C(C1CCCCC1)N(CCN1CC=C(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	2520	203985	70	None	-4	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL1280	203985	70	None	-4	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	CHEMBL6966	203985	70	None	-4	12	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	nan
	118055295	178048	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	242	0	1	2	2.2	FC(F)(F)c1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4647417	178048	0	None	-17	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	242	0	1	2	2.2	FC(F)(F)c1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	11324968	91056	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397880	91056	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	168285382	191496	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5194057	191496	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	44582707	186974	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490634	186974	0	None	1	4	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	430	10	0	6	4.1	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	13091359	113512	0	None	-1479	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321790	113512	0	None	-1479	10	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	53251189	130868	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2B	ChEMBL	452	5	3	7	5.1	Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1	10.6019/CHEMBL5212743
	CHEMBL3685796	130868	6	None	-	1	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000704a HTR2B	ChEMBL	452	5	3	7	5.1	Cc1cc(Nc2nccc(C)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1	10.6019/CHEMBL5212743
	135367405	164172	0	None	-2	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4210782	164172	0	None	-2	7	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	227	1	2	2	2.1	Cc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	122179556	121462	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2B	ChEMBL	303	2	0	3	4.5	FC(F)(F)c1ccc2c(c1)nc(-c1cccnc1)n2C1CC1	10.6019/CHEMBL5212743
	CHEMBL3582461	121462	0	None	2	2	Human	6.0	pKi	=	6.0	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000733a HTR2B	ChEMBL	303	2	0	3	4.5	FC(F)(F)c1ccc2c(c1)nc(-c1cccnc1)n2C1CC1	10.6019/CHEMBL5212743
	15560577	185317	9	None	1	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4859858	185317	9	None	1	10	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	123683	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	422	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	CHEMBL119709	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	DB05511	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) by PDSP screeningBinding affinity to 5HT2B receptor (unknown origin) by PDSP screening	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/jm501021n
	123683	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	422	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	CHEMBL119709	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	DB05511	3099	63	None	-12302	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	510	5	4	9	0.4	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	16115652	83462	0	None	-27	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220211	83462	0	None	-27	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	1	3	1.8	COc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	71061724	145527	0	None	1	5	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	CHEMBL3915107	145527	0	None	1	5	Mouse	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	10660	14384	58	None	-29	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	CHEMBL1200406	14384	58	None	-29	12	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	6	1	7	3.0	CN(C)CCOC(c1ccccc1)c1ccccc1.Cn1c(=O)c2[nH]c(Cl)nc2n(C)c1=O	nan
	134138168	147666	0	None	1	10	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL3931889	147666	0	None	1	10	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	275	4	0	2	4.1	COc1ccccc1-c1cc(CN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	44397832	123083	0	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	256	0	1	2	2.4	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL361079	123083	0	None	-7	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	256	0	1	2	2.4	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)cc3N12	10.1016/j.bmcl.2005.05.074
	118706287	120505	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310114	120505	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545466	120505	0	None	14	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	301	1	3	2	1.8	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1ccc(Cl)cc1-2	10.1016/j.bmc.2014.05.027
	10131066	21571	0	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	2	1	3	2.4	CC(N)Cc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL131736	21571	0	None	-4	3	Human	8.0	pKi	=	8.0	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	2	1	3	2.4	CC(N)Cc1cn(C)c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL5286886	194338	0	None	7	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	405	6	4	8	1.4	OC[C@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1039/D1MD00167A
	134141831	146662	0	None	2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3923870	146662	0	None	2	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	6	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	45486902	196923	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL566396	196923	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	118729270	120676	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402678	120676	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547139	120676	0	None	-1	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	145965628	164023	0	None	-4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4208914	164023	0	None	-4	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	146025727	171661	0	None	-40	27	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	171661	0	None	-40	27	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	132060743	162212	0	None	-4	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
	CHEMBL4163428	162212	0	None	-4	13	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
	10541003	103092	0	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@H]3CO2	10.1021/jm980076u
	CHEMBL307770	103092	0	None	-2	3	Human	5.0	pKi	=	5.0	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@H]3CO2	10.1021/jm980076u
	136118640	76289	0	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058700	76289	0	None	3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	21044391	76602	0	None	-21	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	2	4	0.3	C[C@@H]1CNC[C@H]2Cc3ccc(CO)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL206386	76602	0	None	-21	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	2	4	0.3	C[C@@H]1CNC[C@H]2Cc3ccc(CO)nc3N12	10.1016/j.bmcl.2005.11.083
	2333	142310	97	None	1	2	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	CHEMBL388590	142310	97	None	1	2	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	nan
	11313985	91054	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397878	91054	0	None	-3	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	18715561	73015	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201062	73015	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cccnc3c21	10.1016/j.bmcl.2005.10.029
	46914774	15410	0	None	21	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1215037	15410	0	None	21	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	16115269	138104	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL376676	138104	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	21786603	134838	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	259	3	2	3	1.7	CN1CCN(CCc2c[nH]c3cccc(O)c23)CC1	10.1016/j.bmcl.2005.06.104
	CHEMBL371899	134838	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	259	3	2	3	1.7	CN1CCN(CCc2c[nH]c3cccc(O)c23)CC1	10.1016/j.bmcl.2005.06.104
	127051592	140853	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140853	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140853	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	2771	194994	74	None	1	27	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL1200781	194994	74	None	1	27	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	CHEMBL549	194994	74	None	1	27	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	nan
	127051592	140853	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818710	140853	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819742	140853	0	None	-51	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	317	5	0	2	3.4	[O-][S+](CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	104903	56314	17	None	-4	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	CHEMBL1630578	56314	17	None	-4	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	nan
	58911534	91080	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397904	91080	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	2723	154022	108	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	CHEMBL398440	154022	108	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	nan
	1379258	67766	13	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909050	67766	13	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	3	0	1	4.1	Cc1ccccc1C(=O)N1CCC(Cc2ccccc2)CC1	nan
	16754	85545	50	None	-2	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL228082	85545	50	None	-2	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	5	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	5202	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL39	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	DB08839	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2003.05.001
	CHEMBL5081379	214723	0	None	-1	9	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	58405183	110670	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	CHEMBL3260336	110670	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	339	6	1	3	3.9	FC(F)(COc1ccc(Cl)cc1OC1CNC1)c1ccccc1	10.1021/ml500082j
	11380477	179658	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4743582	179658	0	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	280	2	1	4	2.7	CC(C)n1nc2c(c1-c1ccc(C#N)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	5	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	5202	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	CHEMBL39	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	DB08839	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2005.10.029
	10198431	73876	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201930	73876	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	189	3466	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	5163	3466	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	CHEMBL297784	3466	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	11625624	113061	0	None	-17	7	Human	7.9	pKi	=	7.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	406	4	4	8	0.9	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL331291	113061	0	None	-17	7	Human	7.9	pKi	=	7.9	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	406	4	4	8	0.9	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC4CCCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	189	3466	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	5163	3466	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	CHEMBL297784	3466	39	None	-5	17	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1016/j.bmcl.2013.12.024
	10741816	98162	0	None	-5	3	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3c(C)ccnc3C)c1)CC2	10.1021/jm990388c
	CHEMBL274066	98162	0	None	-5	3	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3c(C)ccnc3C)c1)CC2	10.1021/jm990388c
	10549658	98255	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3ccncc3)cc1)CC2	10.1021/jm990388c
	CHEMBL274692	98255	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(-c3ccncc3)cc1)CC2	10.1021/jm990388c
	18475509	101920	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	3	3.9	CN1CCc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	CHEMBL301209	101920	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	3	3.9	CN1CCc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	191	3472	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
	443389	3472	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
	CHEMBL276140	3472	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970741j
	44298172	101744	0	None	-6	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cncnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL299938	101744	0	None	-6	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cncnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298163	195378	0	None	-25	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL55207	195378	0	None	-25	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	191	3472	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
	443389	3472	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
	CHEMBL276140	3472	52	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	10.1021/jm970424c
	9887537	84316	43	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL221692	84316	43	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	CHEMBL4751170	84316	43	None	-15	9	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	405	4	0	5	4.0	Fc1ccc(-c2cncc(CN3CCN(c4cccc5c4OCCO5)CC3)c2)cc1	10.1021/jm070516u
	44298246	195586	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	397	4	1	5	4.0	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55597	195586	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	397	4	1	5	4.0	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3nccn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	56658155	65633	0	None	13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccccc1CCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834252	65633	0	None	13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccccc1CCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	145972796	164572	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
	CHEMBL4215741	164572	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	236	3	2	4	2.0	CNc1ccccc1C1=N[C@@H](CO)[C@H](C)S1	10.1021/acs.jnatprod.7b00317
	71212556	143537	0	None	-24	6	Human	6.9	pKi	=	6.9	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
	CHEMBL3899169	143537	0	None	-24	6	Human	6.9	pKi	=	6.9	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
	155561439	175642	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	411	4	4	7	3.5	Oc1ccc(CCNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)cc1O	10.1039/C8MD00317C
	CHEMBL4581568	175642	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	411	4	4	7	3.5	Oc1ccc(CCNc2nc(C#Cc3ccc(Cl)s3)nc3[nH]cnc23)cc1O	10.1039/C8MD00317C
	44404899	70403	2	None	-70	4	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	190	2	2	2	1.9	CN(C)Cc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL194588	70403	2	None	-70	4	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	190	2	2	2	1.9	CN(C)Cc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	44404904	132986	1	None	-11	3	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	2	1	3	1.9	CN(C)Cc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL370221	132986	1	None	-11	3	Human	5.9	pKi	=	5.9	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	2	1	3	1.9	CN(C)Cc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	127050699	140847	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819082	140847	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819726	140847	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	117209918	186386	1	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876036	186386	1	None	-3	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	135508617 136016503	10598	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL1170237	10598	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	9869628	72014	0	None	-199	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	440	7	0	4	4.8	COc1cc2c(cc1OCCN1CCCCC1)N(C(=O)/C=C/c1ccccc1Cl)CC2	10.1016/j.bmcl.2005.08.004
	CHEMBL197630	72014	0	None	-199	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	440	7	0	4	4.8	COc1cc2c(cc1OCCN1CCCCC1)N(C(=O)/C=C/c1ccccc1Cl)CC2	10.1016/j.bmcl.2005.08.004
	10127968	72190	0	None	-15	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	479	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198109	72190	0	None	-15	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	479	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	10479409	78034	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(C2=CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL210007	78034	0	None	-25	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(C2=CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	49850874	56432	0	None	-398	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632210	56432	0	None	-398	9	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	450	6	1	4	5.2	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5ccccc5)c4)CC3)cccc2n1	10.1021/jm100714c
	44298243	100634	0	None	-100	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	CHEMBL292228	100634	0	None	-100	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	44298254	194512	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	442	4	1	4	5.8	CCc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL52919	194512	0	None	-50	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	442	4	1	4	5.8	CCc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	22619858	199051	1	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL58765	199051	1	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	18931348	104714	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	389	8	2	6	1.7	COc1ccc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)c1	10.1016/S0960-894X(96)00503-3
	CHEMBL310656	104714	0	None	-39	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	389	8	2	6	1.7	COc1ccc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)c1	10.1016/S0960-894X(96)00503-3
	44324011	111584	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	562	11	3	8	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(F)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL328375	111584	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	562	11	3	8	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(F)cc1	10.1016/S0960-894X(96)00503-3
	148302367	173497	0	None	15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	2	1	2	4.0	CC[C@H]1c2cc(-c3ccccc3)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4530979	173497	0	None	15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	2	1	2	4.0	CC[C@H]1c2cc(-c3ccccc3)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	149396365	175980	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	295	3	1	3	3.5	C[C@@]12COc3cc(OCc4ccccc4)ccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4589450	175980	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	295	3	1	3	3.5	C[C@@]12COc3cc(OCc4ccccc4)ccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	44430976	88012	0	None	-50	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCC(C)C1	10.1016/j.bmcl.2006.10.029
	CHEMBL234492	88012	0	None	-50	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCC(C)C1	10.1016/j.bmcl.2006.10.029
	11236301	88025	0	None	-63	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	450	6	0	4	4.9	COc1ccc(N2Cc3c(F)c(F)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234531	88025	0	None	-63	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	450	6	0	4	4.9	COc1ccc(N2Cc3c(F)c(F)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11475519	152051	0	None	-79	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	414	6	0	4	4.6	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396747	152051	0	None	-79	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	414	6	0	4	4.6	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	44430979	153168	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.8	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1[C@@H](C)CCC[C@H]1C	10.1016/j.bmcl.2006.10.029
	CHEMBL397709	153168	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.8	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1[C@@H](C)CCC[C@H]1C	10.1016/j.bmcl.2006.10.029
	162654275	180656	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4755344	180656	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	310	5	1	4	3.7	COc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	10287730	3510	40	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	77	3510	40	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	CHEMBL425190	3510	40	None	-1584	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor Binding affinity for human 5-hydroxytryptamine 2B receptor	ChEMBL	412	6	0	5	4.3	Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2	10.1021/jm049039v
	10217208	72184	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3cccc(Cl)c3Cl)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198097	72184	0	None	-125	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3cccc(Cl)c3Cl)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	44404608	72223	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	346	6	1	4	2.7	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCO	10.1016/j.bmcl.2005.08.004
	CHEMBL198192	72223	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	346	6	1	4	2.7	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCO	10.1016/j.bmcl.2005.08.004
	10309622	141349	0	None	-1000	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	395	7	0	4	4.0	COc1ccc(N2CCN(c3ccccc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL383800	141349	0	None	-1000	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	395	7	0	4	4.0	COc1ccc(N2CCN(c3ccccc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	44414209	81207	0	None	-398	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	424	7	0	4	4.4	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL215864	81207	0	None	-398	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	424	7	0	4	4.4	COc1ccc(N2CC=C(c3ccc(F)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	9891002	107381	0	None	-1258	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligandBinding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	CHEMBL318018	107381	0	None	-1258	7	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligandBinding affinity to human cloned 5-HT2B receptor in HEK 293 cells using [3H]- -5-HT as radioligand	ChEMBL	472	4	2	6	4.6	Cc1sc2ccc(Cl)cc2c1S(=O)(=O)Nc1ccc2nccc(N3CCNCC3)c2c1	10.1016/s0960-894x(01)00558-3
	11304596	56366	0	None	-7943	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631542	56366	0	None	-7943	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	416	5	0	5	3.9	Cc1ccc2c(N3CCN(CCc4cccc(N5CCOC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	9827938	11739	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181680	11739	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	CHEMBL188486	11739	0	None	-50	12	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	517	13	1	3	6.3	CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1	10.1016/j.bmcl.2005.06.024
	2470	3626	50	None	-14125	60	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	3300	3626	50	None	-14125	60	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	5265	3626	50	None	-14125	60	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	99	3626	50	None	-14125	60	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	CHEMBL267930	3626	50	None	-14125	60	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1016/S0960-894X(96)00503-3
	10008294	206804	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	574	12	3	9	2.5	COc1ccc(S(=O)(=O)Nc2cc(C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O)c(OC)cc2OC)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90467	206804	0	None	-63	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	574	12	3	9	2.5	COc1ccc(S(=O)(=O)Nc2cc(C(=O)CCCCN3CCC4(CC3)NC(=O)NC4=O)c(OC)cc2OC)cc1	10.1016/S0960-894X(96)00503-3
	10371119	206984	0	None	-794	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	8	3.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL91454	206984	0	None	-794	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	8	3.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)C)cc1	10.1016/S0960-894X(96)00503-3
	127050699	140847	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819082	140847	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	CHEMBL3819726	140847	0	None	-14	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	3	0	1	4.0	Fc1ccc2c(c1)CC(CCN1CCc3ccccc3C1)C2	10.1016/j.bmc.2016.05.053
	122182283	121984	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2cccc(O)c2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593949	121984	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	3	2	4	3.0	O=c1cc(CCc2cccc(O)c2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	9935387	99414	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL282971	99414	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1	10.1016/s0960-894x(02)00172-5
	9913554	100965	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL29433	100965	0	None	-1584	14	Human	5.9	pKi	=	5.9	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	491	5	1	6	5.0	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1	10.1016/s0960-894x(02)00172-5
	136030693	57290	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/np100588c
	CHEMBL1651092	57290	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/np100588c
	13149	2528	36	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
	3034396	2528	36	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL299031	2528	36	None	-20	17	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@@H]1CN2CCC3=C([C@@H]2C[C@@H]1/C(=C\OC)/C(=O)OC)NC4=C3C(=CC=C4)OC	10.1021/acs.jmedchem.1c00726
	1201549	594	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	333	594	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	7601	594	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL1201203	594	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	CHEMBL438151	594	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	DB00245	594	24	None	-26	20	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	nan
	118055293	177221	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	252	0	1	2	1.9	Brc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4635854	177221	0	None	-17	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	252	0	1	2	1.9	Brc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	58911604	91077	1	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397901	91077	1	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2ccc(Cl)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	135846982	93026	0	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cc(Br)ccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442268	93026	0	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cc(Br)ccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	5510	205829	100	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	CHEMBL83668	205829	100	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	nan
	135846955	189459	4	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)N/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL513803	189459	4	None	7	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)N/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	4122	207602	108	None	-3	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	CHEMBL9514	207602	108	None	-3	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	301	3	2	5	3.0	COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1	nan
	71682216	91085	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	260	3	1	3	1.4	CCCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397909	91085	0	None	-1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	260	3	1	3	1.4	CCCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL4754103	214016	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000328a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000328a HTR2B	ChEMBL		None	None	None		CNC(=O)Nc1ccc2c(c1)CC[C@]21OC(=O)N(CC(=O)N(Cc2ccc(F)cc2)[C@@H](C)C(F)(F)F)C1=O	10.6019/CHEMBL5212743
	92042876	151312	0	None	-2	10	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL3961059	151312	0	None	-2	10	Human	7.9	pKi	=	7.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL	261	4	1	2	3.7	CNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	9920815	67219	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL188033	67219	0	None	-7	3	Human	7.9	pKi	=	7.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	5	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	5202	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	CHEMBL39	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	DB08839	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm050663x
	152	363	29	None	1	19	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	2107	363	29	None	1	19	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	CHEMBL275854	363	29	None	1	19	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm050663x
	24826790	91065	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397889	91065	0	None	-1	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	46230095	199268	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	271	0	2	3	1.2	O=C1NC2CNCCN2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590333	199268	0	None	11	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	271	0	2	3	1.2	O=C1NC2CNCCN2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2009.12.014
	127048336	140580	1	None	5	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2I)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813855	140580	1	None	5	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2I)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	5	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	5202	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	CHEMBL39	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	DB08839	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm030205t
	152	363	29	None	1	19	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
	2107	363	29	None	1	19	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
	CHEMBL275854	363	29	None	1	19	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	10.1021/jm030205t
	9856041	24082	3	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL133868	24082	3	None	-3	8	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	CC(N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	5	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	5202	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	CHEMBL39	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	DB08839	139	72	None	-13	55	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1016/j.bmcl.2014.02.029
	156013985	177151	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter methodDisplacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
	CHEMBL4634785	177151	0	None	-2	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter methodDisplacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from recombinant human 5HT2B receptor expressed in CHO cells measured after 120 mins by scintillation counter method	ChEMBL	230	0	1	2	1.8	C1=CC2CNCCN3C[C@@H]4CCC[C@@H]4C(=C1)C23	10.1016/j.bmcl.2019.126929
	45486824	197354	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL569251	197354	0	None	-14	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL5094234	215550	0	None	-61	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096019	215550	0	None	-61	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5090884	215554	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5096072	215554	0	None	-1	7	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	24771120	184076	0	None	-56	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	CHEMBL482562	184076	0	None	-56	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmcl.2009.03.071
	136020618	163890	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4207302	163890	0	None	12	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	135753074	191084	9	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5187824	191084	9	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	341	4	2	5	2.2	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2ccccc2F)n1	10.1021/acs.jmedchem.1c01759
	136030693	57290	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	CHEMBL1651092	57290	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	222	2	2	4	0.7	NC(=O)C1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	11739217	137015	0	None	-8	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374660	137015	0	None	-8	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	300	2	1	3	2.2	CCOc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	16063039	155591	0	None	-147	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCCNC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL404581	155591	0	None	-147	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.9	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCCNC3)cc1	10.1016/j.bmcl.2008.01.090
	1353	1898	93	None	-295	86	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	3559	1898	93	None	-295	86	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	86	1898	93	None	-295	86	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL54	1898	93	None	-295	86	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	DB00502	1898	93	None	-295	86	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
	CHEMBL4537673	213966	29	None	-	1	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000305b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000305b HTR2B	ChEMBL		None	None	None		C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(N(C)C)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1	10.6019/CHEMBL5212743
	44409332	76701	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL206618	76701	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	162661262	181828	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	432	6	4	7	2.7	OC[C@@]12C[C@@H]1[C@@H](n1ccc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1016/j.bmcl.2020.127599
	CHEMBL4778636	181828	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	432	6	4	7	2.7	OC[C@@]12C[C@@H]1[C@@H](n1ccc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1016/j.bmcl.2020.127599
	1016	3720	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2561	3720	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	2733526	3720	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	5384	3720	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	CHEMBL83	3720	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	DB00675	3720	78	None	-17	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
	71061585	160473	0	None	3	2	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	367	6	0	5	2.8	Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	CHEMBL4112090	160473	0	None	3	2	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	367	6	0	5	2.8	Cc1ccnc(C)c1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	CHEMBL1909069	209053	0	None	-1	3	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL		None	None	None		None	nan
	117209971	186461	1	None	-26	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877051	186461	1	None	-26	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	1343	1876	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	3519	1876	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	522	1876	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	CHEMBL862	1876	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	DB01018	1876	62	None	-14	9	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	nan
	CHEMBL4780458	214025	0	None	-5	4	Human	5.9	pKi	=	5.9	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000540a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000540a HTR2B	ChEMBL		None	None	None		O=C(Nc1cccnn1)N1CC(C/C=C/c2cncc(Oc3ccc(C(F)(F)F)cn3)n2)C1	10.6019/CHEMBL5212743
	58911681	90956	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL2396668	90956	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	136118639	76288	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058699	76288	0	None	1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	2337	3232	77	None	-15	63	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	50	3232	77	None	-15	63	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	5002	3232	77	None	-15	63	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	CHEMBL716	3232	77	None	-15	63	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	DB01224	3232	77	None	-15	63	Human	6.9	pKi	=	6.9	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
	71455625	82935	0	None	-3388	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181170	82935	0	None	-3388	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	353	5	0	4	4.4	CCCN1CCC(COc2nc3c(F)cccc3c3ncccc23)CC1	10.1021/jm300943r
	44407398	74389	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	CHEMBL202616	74389	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	365	5	1	3	5.5	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2ccccc2c1	10.1016/j.bmcl.2005.10.029
	136030596	57288	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/np100588c
	CHEMBL1651090	57288	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/np100588c
	168277287	190126	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	426	7	2	3	7.8	CCCC(CCC)c1nc2c(Nc3ccc(Cl)c(Cl)c3)nc3ccccc3c2[nH]1	10.1021/acs.jmedchem.2c01170
	CHEMBL5173661	190126	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	426	7	2	3	7.8	CCCC(CCC)c1nc2c(Nc3ccc(Cl)c(Cl)c3)nc3ccccc3c2[nH]1	10.1021/acs.jmedchem.2c01170
	25123011	201170	0	None	-74	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccc5ccccc5c4)c3c2)CC1	10.1021/jm901674f
	CHEMBL603483	201170	0	None	-74	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	2	5	3.5	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccc5ccccc5c4)c3c2)CC1	10.1021/jm901674f
	46230046	199224	0	None	14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590077	199224	0	None	14	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	203	0	2	3	0.2	O=C1NC2CNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	135846958	76216	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058408	76216	0	None	2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	18715555	74346	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	CHEMBL202458	74346	0	None	-8	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	359	5	1	5	4.1	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2005.10.029
	168286940	192257	0	None	-691	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysisDisplacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysis	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	CHEMBL5205903	192257	0	None	-691	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysisDisplacement of [3H]-LSD from human 5-HT2B receptor at 25 uM incubated for 1 hr by microbeta2 beta-counter analysis	ChEMBL	454	7	1	4	4.0	CN1CCC(N(Cc2ccc(F)cn2)C(=O)NCc2ccc(OCC(F)(F)F)cc2)CC1	10.1016/j.ejmech.2022.114246
	76518514	113510	0	None	-147	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321788	113510	0	None	-147	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	387	6	1	2	5.3	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCCc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	58911582	91070	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397894	91070	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	59012632	87709	0	None	91	2	Human	7.9	pKi	=	7.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	388	2	1	3	4.6	COc1ccc(-c2cc3c4c(c2)[C@@H]2CNCC[C@@H]2N4CCC3)c(C(F)(F)F)c1	10.1016/j.bmcl.2012.10.091
	CHEMBL2337102	87709	0	None	91	2	Human	7.9	pKi	=	7.9	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	388	2	1	3	4.6	COc1ccc(-c2cc3c4c(c2)[C@@H]2CNCC[C@@H]2N4CCC3)c(C(F)(F)F)c1	10.1016/j.bmcl.2012.10.091
	127051482	140629	1	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccc(F)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814737	140629	1	None	8	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2ccc(F)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127050282	140648	1	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2cccc(Br)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815066	140648	1	None	7	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2cccc(Br)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	10353268	97742	1	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL27173	97742	1	None	-2	4	Human	7.9	pKi	=	7.9	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	216	2	2	2	2.0	NCCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	24893978	1007	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
	8872	1007	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
	CHEMBL495075	1007	9	None	-35	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	525	6	2	4	4.9	Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl	10.1016/j.bmcl.2008.06.019
	10176869	166003	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL425545	166003	0	None	-4	3	Human	6.9	pKi	=	6.9	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	222	0	1	2	2.0	Cc1c(Cl)ccc2c1N1CCNC[C@@H]1C2	10.1016/j.bmcl.2005.05.074
	11595191	89031	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337488	89031	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364960	89031	0	None	1	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	298	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N(C)[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	854531	152970	30	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	244	1	1	1	4.4	c1ccc(-c2nccc3c2[nH]c2ccccc23)cc1	10.1021/acs.jmedchem.0c01887
	CHEMBL3975325	152970	30	None	1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	244	1	1	1	4.4	c1ccc(-c2nccc3c2[nH]c2ccccc23)cc1	10.1021/acs.jmedchem.0c01887
	145978819	163857	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2cccs2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4206939	163857	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2cccs2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	145975226	163909	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	CHEMBL4207529	163909	0	None	-2	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	388	6	3	7	1.3	COC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1N=C(c2ccccc2O)S[C@@H]1C	10.1021/acs.jnatprod.7b00317
	145976983	163982	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4208376	163982	0	None	-4	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	333	4	1	3	4.6	C[C@H]1SC(c2ccc(-c3ccccc3)cc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	136030596	57288	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	CHEMBL1651090	57288	1	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	209	2	2	4	1.2	OC[C@@H]1CSC(c2ccccc2O)=N1	10.1021/acs.jnatprod.7b00317
	44537940	18742	0	None	-18	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	482	5	1	6	4.5	O=S(=O)(c1cccc2ccccc12)c1nn(Cc2ccccc2)c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	CHEMBL1278001	18742	0	None	-18	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	482	5	1	6	4.5	O=S(=O)(c1cccc2ccccc12)c1nn(Cc2ccccc2)c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	16115513	136377	0	None	-23	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL373531	136377	0	None	-23	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	136118732	76217	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2c(Br)cccc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058409	76217	0	None	-1	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2c(Br)cccc12	10.1016/j.bmc.2013.09.011
	122187383	123004	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(CC1CC1)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609148	123004	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(CC1CC1)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	72549033	110666	0	None	-660	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometryDisplacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometry	ChEMBL	367	3	0	5	3.3	CN1CCC(c2cccc3cc(S(=O)(=O)c4ccccn4)cnc23)CC1	10.1021/ml500045k
	CHEMBL3260311	110666	0	None	-660	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometryDisplacement of [125I]-R-O-DOI from human 5-HT2B receptor expressed in CHO-K1 cells by by liquid scintillation spectrometry	ChEMBL	367	3	0	5	3.3	CN1CCC(c2cccc3cc(S(=O)(=O)c4ccccn4)cnc23)CC1	10.1021/ml500045k
	155536080	172090	0	None	2	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4472703	172090	0	None	2	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	2	1	2	2.9	CC[C@H]1c2cc(OC)ccc2CC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	142601333	185739	0	None	-63	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4866412	185739	0	None	-63	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	71062646	149519	0	None	-2398	13	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	CHEMBL3946661	149519	0	None	-2398	13	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
	56675412	65636	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	334	6	0	3	4.2	c1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834255	65636	0	None	6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	334	6	0	3	4.2	c1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	134141050	147279	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.4	O=C(O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3928983	147279	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.4	O=C(O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	21302483	87710	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	246	0	1	3	2.4	c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCCS2	10.1016/j.bmcl.2012.10.091
	CHEMBL2337103	87710	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Agonist activity at 5-HT2B receptor (unknown origin)Agonist activity at 5-HT2B receptor (unknown origin)	ChEMBL	246	0	1	3	2.4	c1cc2c3c(c1)[C@@H]1CNCC[C@@H]1N3CCCS2	10.1016/j.bmcl.2012.10.091
	CHEMBL5094680	215487	0	None	3	8	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	46914487	15378	0	None	144	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214830	15378	0	None	144	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL5288004	194381	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1039/D1MD00167A
	71461603	78509	1	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL2112055	78509	1	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	2585	800	103	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	522	800	103	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	551	800	103	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	CHEMBL723	800	103	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	DB01136	800	103	None	-18	22	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
	2389	3306	118	None	-66	68	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	5073	3306	118	None	-66	68	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	96	3306	118	None	-66	68	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	CHEMBL85	3306	118	None	-66	68	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	DB00734	3306	118	None	-66	68	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
	135520431	72580	9	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL199385	72580	9	None	-1	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	177	2	2	4	0.7	NCCn1ncc2ccc(O)cc21	10.1021/jm050663x
	24873257	180232	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4750414	180232	0	None	10	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	289	2	1	3	3.2	c1ccc(-c2c3c(nn2-c2ccccc2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	168274008	190172	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5174366	190172	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	134143752	150625	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3955519	150625	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	134143752	150625	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL3955519	150625	0	None	3	5	Human	7.8	pKi	=	7.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	447	7	3	9	1.9	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	24824726	161085	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
	CHEMBL4060529	161085	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
	CHEMBL4117079	161085	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
	CHEMBL5282336	161085	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
	CHEMBL5286389	161085	1	None	-20	6	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human 5-HT2B receptorAntagonist activity at human 5-HT2B receptor	ChEMBL	496	11	1	6	3.6	COCCCC(=O)NCCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O	10.1021/acsmedchemlett.7b00112
	10550406	31923	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3C)c1)CC2	10.1021/jm990388c
	CHEMBL14076	31923	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3C)c1)CC2	10.1021/jm990388c
	10718089	98528	0	None	-31	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	443	4	1	4	5.4	COc1ccc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc1-c1cccnc1	10.1021/jm990388c
	CHEMBL276571	98528	0	None	-31	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	443	4	1	4	5.4	COc1ccc(NC(=O)N2CCc3cc(OC)c(C(F)(F)F)cc32)cc1-c1cccnc1	10.1021/jm990388c
	10767350	99014	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	489	4	1	3	7.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL280297	99014	0	None	-6	3	Human	7.8	pKi	=	7.8	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	489	4	1	3	7.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3ccccc3)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	18475610	196773	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	327	3	2	3	4.5	COc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1Cl	10.1016/s0960-894x(01)00343-2
	CHEMBL56557	196773	0	None	3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	327	3	2	3	4.5	COc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1Cl	10.1016/s0960-894x(01)00343-2
	10714852	163126	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	381	4	1	3	5.2	CCCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL41792	163126	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	381	4	1	3	5.2	CCCSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	44298082	194941	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ncccc3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL54484	194941	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ncccc3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	118055289	177875	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.7	Cc1cc2c3c(c1Cl)C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4644872	177875	0	None	-19	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.7	Cc1cc2c3c(c1Cl)C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	10421236	188709	1	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	226	1	3	4	1.9	Nc1nccc(-c2c[nH]c3cccc(O)c23)n1	10.1016/j.bmc.2011.08.033
	CHEMBL50498	188709	1	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	226	1	3	4	1.9	Nc1nccc(-c2c[nH]c3cccc(O)c23)n1	10.1016/j.bmc.2011.08.033
	135367857	164580	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4215875	164580	0	None	-9	8	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	228	1	1	3	2.3	Cc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL5280298	194036	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	294	1	1	1	5.5	c1ccc2cc(-c3nccc4c3[nH]c3ccccc34)ccc2c1	10.1021/acs.jmedchem.0c01887
	145967795	164799	0	None	5	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4218679	164799	0	None	5	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	213	2	1	4	2.0	C[C@@H]1SC(c2ccsc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	136259032	164616	17	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	205	2	1	4	2.3	O=Cc1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	CHEMBL4216337	164616	17	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	205	2	1	4	2.3	O=Cc1csc(-c2ccccc2O)n1	10.1021/acs.jnatprod.7b00317
	CHEMBL4802045	214036	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
	732268	138271	33	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770837	138271	33	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	257	1	3	5	2.0	NC1=NC2(CCCCC2)NC(Nc2ccccc2)=N1	10.1021/acsmedchemlett.8b00300
	127051843	140726	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140726	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	1222	1651	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	3396	1651	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	85	1651	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	CHEMBL46516	1651	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	DB04842	1651	49	None	-52	33	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm100600y
	CHEMBL4802045	214036	6	None	-	1	Human	5.8	pKi	=	5.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC[C@@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
	2398	951	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	2801	951	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	701	951	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	CHEMBL415	951	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	DB01242	951	62	None	-3	29	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
	127051843	140726	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818200	140726	0	None	-6	9	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	304	5	0	3	3.6	N#Cc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	155543832	173187	0	None	-134	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	451	6	3	7	3.4	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4522864	173187	0	None	-134	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	451	6	3	7	3.4	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	11952353	199837	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	CHEMBL594469	199837	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	345	4	1	4	3.0	Fc1ccc(F)c(CO[C@H]2CCc3ccc(N4CCNCC4)nc32)c1	10.1016/j.bmcl.2009.10.112
	168274751	190614	0	None	2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5181312	190614	0	None	2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	11302765	84219	4	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL221113	84219	4	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.4	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	10235	2656	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
	137553161	2656	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
	CHEMBL4470080	2656	1	None	-61	6	Human	6.8	pKi	=	6.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	433	6	4	8	2.1	OC[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC(C1CCC1)C1CCC1	10.1021/acs.jmedchem.8b01662
	CHEMBL4545807	213971	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000748a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000748a HTR2B	ChEMBL		None	None	None		Cn1c(-c2csc(C3CCN(CC4=NC5N=CC=CC5N4)CC3)n2)nc2ccccc21	10.6019/CHEMBL5212743
	56645363	121464	12	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
	CHEMBL3582478	121464	12	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000313b HTR2B	ChEMBL	311	3	1	4	3.8	CC(C)(O)c1cncc(-c2nc3ccc(F)cc3n2C2CC2)c1	10.6019/CHEMBL5212743
	136118650	76294	0	None	6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058705	76294	0	None	6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	44581972	175576	0	None	-5	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL458001	175576	0	None	-5	10	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	499	6	2	6	4.3	O=C(Nc1cccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)c1)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	136020620	57294	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	219	2	1	4	2.6	Cc1sc(-c2ccccc2O)nc1C=O	10.1021/np100588c
	CHEMBL1651096	57294	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	219	2	1	4	2.6	Cc1sc(-c2ccccc2O)nc1C=O	10.1021/np100588c
	142601325	185845	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4868035	185845	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.9	c1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	16117151	60057	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642882	60057	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739102	60057	0	None	-154	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	390	4	3	5	3.2	O=S(=O)(c1cccc(Cl)c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	25263297	184313	0	None	-19	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	CHEMBL484345	184313	0	None	-19	4	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	394	5	2	6	2.7	NCCC(=O)Nc1cccc2c1cnn2S(=O)(=O)c1cccc2ccccc12	10.1016/j.bmcl.2009.03.071
	53483975	65584	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1833977	65584	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	1605	2327	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	3957	2327	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	7216	2327	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	CHEMBL998	2327	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	DB00455	2327	117	None	-1	4	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	nan
	168282554	190842	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OC(C)C)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5184659	190842	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OC(C)C)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	155530292	171470	0	None	-3548	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	458	5	4	8	1.6	O=C(NC1CC1)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4463802	171470	0	None	-3548	7	Human	5.8	pKi	=	5.8	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	458	5	4	8	1.6	O=C(NC1CC1)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	10151289	133558	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	434	6	0	4	4.7	O=C1N(c2ccc(OCCN3CCCCC3)nc2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2005.08.004
	CHEMBL371211	133558	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	434	6	0	4	4.7	O=C1N(c2ccc(OCCN3CCCCC3)nc2)CCN1c1ccc(Cl)c(Cl)c1	10.1016/j.bmcl.2005.08.004
	49850872	56428	0	None	-630	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632206	56428	0	None	-630	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	388	5	1	4	3.9	CC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	10830245	101397	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	329	1	1	2	4.6	CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL297445	101397	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	329	1	1	2	4.6	CC(C)(C)c1cc2c(cc1Cl)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	10408409	193139	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL52308	193139	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nn1)CC2	10.1016/s0960-894x(00)00364-4
	44298226	196462	0	None	-100	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	378	3	1	4	4.6	Cc1cc2c(cc1F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL56336	196462	0	None	-100	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	378	3	1	4	4.6	Cc1cc2c(cc1F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	153287542	169510	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4435237	169510	0	None	-6	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3c(-c4ccccc4)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11237290	87928	0	None	-199	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	458	6	0	4	4.7	COc1ccc(N2Cc3cccc(Br)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234109	87928	0	None	-199	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	458	6	0	4	4.7	COc1ccc(N2Cc3cccc(Br)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10413268	152643	0	None	-31	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	453	6	0	5	4.9	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL397259	152643	0	None	-31	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	453	6	0	5	4.9	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	44420682	137583	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	CHEMBL375642	137583	0	None	-3	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	0	2	2.1	CN1CCN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2C1	10.1021/jm0612968
	162647275	179538	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	CHEMBL4741776	179538	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1ccc(CCCc2cc(=O)c3c(O)cccc3o2)cc1	10.1016/j.bmcl.2020.127511
	10150393	71880	0	None	-398	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	373	7	0	4	3.2	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN(C)C	10.1016/j.bmcl.2005.08.004
	CHEMBL197170	71880	0	None	-398	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	373	7	0	4	3.2	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN(C)C	10.1016/j.bmcl.2005.08.004
	10479309	79718	0	None	-79	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	458	8	0	5	4.7	COc1ccc(N2CCC(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1Cl	10.1016/j.bmcl.2006.05.034
	CHEMBL211719	79718	0	None	-79	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	458	8	0	5	4.7	COc1ccc(N2CCC(c3ccc(OC)c(OCCN4CCCCC4)c3)C2=O)cc1Cl	10.1016/j.bmcl.2006.05.034
	44414217	80114	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	516	7	0	4	6.3	O=C1C(c2ccc(Cl)c(Cl)c2)CCN1c1ccc(OC(F)(F)F)c(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.05.034
	CHEMBL213368	80114	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	516	7	0	4	6.3	O=C1C(c2ccc(Cl)c(Cl)c2)CCN1c1ccc(OC(F)(F)F)c(OCCN2CCCCC2)c1	10.1016/j.bmcl.2006.05.034
	24887284	141721	0	None	-125	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL385921	141721	0	None	-125	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	24888183	141794	0	None	-1000	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	420	7	0	4	4.5	COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL386332	141794	0	None	-1000	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	420	7	0	4	4.5	COc1ccc(N2CC=C(c3ccc(C)cc3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	10296414	3505	15	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	76	3505	15	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	CHEMBL183460	3505	15	None	-1258	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	431	6	1	5	4.2	O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C	10.1016/j.bmcl.2006.11.031
	11248705	90266	0	None	-630	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238519	90266	0	None	-630	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4ccc5c(c4F)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	91826739	121987	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	4	1	4	3.2	O=c1cc(COCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593952	121987	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	282	4	1	4	3.2	O=c1cc(COCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	168271856	190537	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5180016	190537	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	44572166	12428	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL1186133	12428	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	CHEMBL451232	12428	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	199	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccc(F)cc1Cl	10.1021/jm801354e
	44572751	12467	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1186509	12467	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	CHEMBL467736	12467	1	None	4	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NC[C@H]1C[C@@H]1c1ccccc1Br	10.1021/jm801354e
	127026052	137528	0	None	4	19	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754496	137528	0	None	4	19	Human	7.8	pKi	=	7.8	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	258	7	1	1	3.5	C=CCN(CC=C)CCc1c[nH]c2ccc(F)cc12	10.1016/j.bmcl.2015.12.053
	145989551	167114	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	297	3	0	2	4.1	CN(C)CC/C=C1\c2ccc(F)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	CHEMBL4290607	167114	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	297	3	0	2	4.1	CN(C)CC/C=C1\c2ccc(F)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	70687202	77949	0	None	-10	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	CHEMBL2096809	77949	0	None	-10	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	11231392	84865	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223628	84865	0	None	-13	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.6	CC(C)Oc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	11080	29054	79	None	-6	6	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	CHEMBL1381098	29054	79	None	-6	6	Human	4.8	pKi	=	4.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
	59652086	114566	0	None	-85	2	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2B	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
	CHEMBL3337895	114566	0	None	-85	2	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000726a HTR2B	ChEMBL	448	8	2	6	3.6	COc1cccc(CNC(=O)c2nc3scc(CN(C)Cc4ccccc4)c3c(=O)[nH]2)c1	10.6019/CHEMBL5212743
	49865833	16132	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.2	O=C(Nc1ccccc1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224036	16132	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.2	O=C(Nc1ccccc1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	14702424	18532	69	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	176	2	2	2	1.6	COc1ccc2[nH]cc(CN)c2c1	10.1021/jm100600y
	CHEMBL1276050	18532	69	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	176	2	2	2	1.6	COc1ccc2[nH]cc(CN)c2c1	10.1021/jm100600y
	71462776	82934	0	None	-134	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181169	82934	0	None	-134	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	460	5	0	3	5.5	CCCN1CCC(COc2nc3c(I)cccc3c3ccccc23)CC1	10.1021/jm300943r
	136118659	76226	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058427	76226	0	None	1	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	21527771	70127	1	None	-645	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940404	70127	1	None	-645	10	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	134135745	144354	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3905850	144354	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	134156506	154039	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3984645	154039	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	407	6	4	8	1.6	CC(C)[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	58911666	91062	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397886	91062	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	25120700	81210	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	369	7	1	5	3.0	COc1ccc(N2CCN(CC[C@@H](OC(N)=O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.02.023
	CHEMBL2158704	81210	0	None	5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	369	7	1	5	3.0	COc1ccc(N2CCN(CC[C@@H](OC(N)=O)c3ccccc3)CC2)cc1	10.1016/j.bmcl.2012.02.023
	45486820	196911	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL1237149	196911	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL566356	196911	0	None	-12	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	432	3	2	4	3.8	O=c1[nH]c2cccc(N3C[C@H]4C[C@@H]3CN4CC3CCc4[nH]c5ccc(F)cc5c4C3)c2o1	10.1016/j.bmcl.2009.08.050
	45279963	80880	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
	CHEMBL2152944	80880	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
	71062768	143711	0	None	-4	4	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3900699	143711	0	None	-4	4	Mouse	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	3151	1450	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	945	1450	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	965	1450	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	CHEMBL219916	1450	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	DB01184	1450	97	None	-125	27	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	nan
	44409317	141333	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@@H]2Cc3ccc(Br)nc3N21	10.1016/j.bmcl.2005.11.083
	CHEMBL383694	141333	0	None	-7	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@@H]2Cc3ccc(Br)nc3N21	10.1016/j.bmcl.2005.11.083
	46884102	8030	1	None	-912	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091106	8030	1	None	-912	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	366	5	2	3	3.7	CC1(C)CCC(Oc2cc(F)c(CNC(=O)[C@@H]3CCCN3)cc2F)CC1	10.1016/j.bmcl.2010.01.107
	135501716	76284	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058695	76284	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	49783419	17717	0	None	-501	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258671	17717	0	None	-501	13	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	366	6	1	6	2.8	CCCCN1CCC(COC(=O)c2cc(F)c(N)c3c2OCCO3)CC1	10.1021/jm100668r
	118055288	177012	0	None	-58	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	2	3.0	CC1CN2CCNCc3cc(Cl)c(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4632473	177012	0	None	-58	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	2	3.0	CC1CN2CCNCc3cc(Cl)c(Cl)c1c32	10.1016/j.bmcl.2019.126929
	25209356	179761	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	544	7	2	8	4.0	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1	10.1021/jm800962k
	CHEMBL474473	179761	0	None	-1	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	544	7	2	8	4.0	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)c(Cl)c4=O)c3C)cc2)cn1	10.1021/jm800962k
	127051015	140849	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140849	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140849	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	24826957	91088	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397912	91088	0	None	3	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1ccc(C)c2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	127049983	140637	1	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(Cl)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814821	140637	1	None	7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(Cl)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127037093	136483	0	None	40	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736252	136483	0	None	40	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	433	11	0	5	4.8	COc1ccc(CCN(CCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	44435193	91196	0	None	1	7	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	331	2	0	2	5.6	CC(C(=O)N1c2ccccc2Sc2ccccc21)c1ccccc1	10.1016/j.bmcl.2013.04.082
	CHEMBL240045	91196	0	None	1	7	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	331	2	0	2	5.6	CC(C(=O)N1c2ccccc2Sc2ccccc21)c1ccccc1	10.1016/j.bmcl.2013.04.082
	CHEMBL5083607	214850	0	None	-14	9	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCN(C)C2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	CHEMBL5093342	215541	0	None	-19	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095971	215541	0	None	-19	7	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	10334023	112855	5	None	1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	283	1	2	1	4.9	c1ccc2c(-c3nccc4c3[nH]c3ccccc34)c[nH]c2c1	10.1021/acs.jmedchem.0c01887
	CHEMBL3309924	112855	5	None	1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	283	1	2	1	4.9	c1ccc2c(-c3nccc4c3[nH]c3ccccc34)c[nH]c2c1	10.1021/acs.jmedchem.0c01887
	CHEMBL5268604	193550	0	None	1	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5-HT2BR (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2BR (unknown origin) assessed as inhibition constant	ChEMBL	299	1	3	2	4.6	Oc1ccc2[nH]c3c(-c4c[nH]c5ccccc45)nccc3c2c1	10.1021/acs.jmedchem.0c01887
	162647063	179624	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	499	6	4	8	1.6	CC(C)[C@@H](Nc1nc(I)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	CHEMBL4743059	179624	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	499	6	4	8	1.6	CC(C)[C@@H](Nc1nc(I)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	162646751	179718	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	419	7	4	9	1.7	CSc1nc(N[C@H](C(C)C)C2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@]4(CO)C[C@H]34)c2n1	10.1016/j.bmcl.2020.127599
	CHEMBL4744176	179718	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	419	7	4	9	1.7	CSc1nc(N[C@H](C(C)C)C2CC2)c2ncn([C@H]3[C@H](O)[C@H](O)[C@]4(CO)C[C@H]34)c2n1	10.1016/j.bmcl.2020.127599
	90469115	185818	4	None	-56	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	CHEMBL4867565	185818	4	None	-56	17	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	410	3	1	6	3.0	O=S(=O)(c1cccc(F)c1)n1ccc2c(N3CCNCC3)nc3ccccc3c21	10.1021/acs.jmedchem.1c00224
	67978437	120651	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402657	120651	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547010	120651	0	None	-85	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	44404887	134404	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	340	8	2	4	3.0	CCCCn1cc(CCN(C)C)c2c(OP(=O)(O)O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL371753	134404	0	None	-1	4	Human	6.8	pKi	=	6.8	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	340	8	2	4	3.0	CCCCn1cc(CCN(C)C)c2c(OP(=O)(O)O)cccc21	10.1016/j.bmcl.2005.06.104
	127051015	140849	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818128	140849	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819731	140849	0	None	-63	9	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	283	5	0	1	4.2	Fc1ccc(CCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	11652359	89099	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337502	89099	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365706	89099	0	None	-4	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1N(C)C2=O	10.1016/j.bmcl.2012.10.091
	45279963	80880	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
	CHEMBL2152944	80880	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL4507316
	45279963	80880	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL5212743
	CHEMBL2152944	80880	55	None	20	2	Human	6.8	pKi	=	6.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000717a HTR2B	ChEMBL	425	6	3	5	3.8	O=C1c2ccc(Nc3ccc(F)cc3F)cc2CCc2ccc(OC[C@H](O)CO)cc21	10.6019/CHEMBL5212743
	46884101	8028	0	None	-87	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	310	6	2	3	2.6	O=C(NCc1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091104	8028	0	None	-87	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	310	6	2	3	2.6	O=C(NCc1ccc(OCc2ccccc2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	25263302	191960	0	None	-134	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	CHEMBL520129	191960	0	None	-134	5	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2b receptorBinding affinity to 5HT2b receptor	ChEMBL	434	4	2	6	3.4	O=C(Nc1ccc2cnn(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCCNC1	10.1016/j.bmcl.2009.03.071
	44409290	74622	0	None	-45	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203013	74622	0	None	-45	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.7	C[C@@H]1CNC[C@H]2Cc3ccc(COCC4CC4)nc3N12	10.1016/j.bmcl.2005.11.083
	16117279	60106	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1642886	60106	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	CHEMBL1739606	60106	0	None	-1778	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	398	5	3	5	3.7	CC(C)c1ccc(S(=O)(=O)c2n[nH]c3ccc(NC4CCNCC4)cc23)cc1	10.1016/j.bmc.2010.10.033
	57799326	89079	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337104	89079	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365468	89079	0	None	-2	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	242	1	2	2	1.7	Cc1cc(C2CC2)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	145988693	167142	0	None	-7	17	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4291048	167142	0	None	-7	17	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	153287572	173398	0	None	11	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	205	1	1	2	2.6	CC[C@H]1c2cc(C)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4528651	173398	0	None	11	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	205	1	1	2	2.6	CC[C@H]1c2cc(C)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	49865887	16149	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	302	1	1	3	3.0	O=C(NC1CCCCC1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224103	16149	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	302	1	1	3	3.0	O=C(NC1CCCCC1)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	1227	2472	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	2331	2472	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	3957	2472	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	4992	2472	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	CHEMBL511	2472	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	DB06691	2472	43	None	-112	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	nan
	118055202	177170	0	None	-12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.5	CC1(C)CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4635105	177170	0	None	-12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	236	0	1	2	2.5	CC1(C)CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	118055282	177990	0	None	-22	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	334	1	1	2	3.4	FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4646572	177990	0	None	-22	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	334	1	1	2	3.4	FC(F)(F)CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	157	2056	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	9840090	2056	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	CHEMBL134519	2056	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm050663x
	46230049	201522	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL605402	201522	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	18715564	73351	0	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201454	73351	0	None	-7	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	259	2	1	3	3.2	C[C@H](N)Cn1ccc2cc(Cl)c3ncccc3c21	10.1016/j.bmcl.2005.10.029
	127053028	140617	1	None	8	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(I)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814559	140617	1	None	8	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2cccc(I)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127049982	140641	1	None	9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2cccc(F)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3815000	140641	1	None	9	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	465	12	0	5	5.3	COc1ccc(CCN(CCCc2cccc(F)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	16115517	84809	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL223468	84809	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1ccc2c(c1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	23151712	120510	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310120	120510	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545471	120510	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	266	1	3	2	1.1	NC(N)=NC(=O)c1ccc2c(c1)C(N)c1ccccc1-2	10.1016/j.bmc.2014.05.027
	157	2056	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
	9840090	2056	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
	CHEMBL134519	2056	7	None	-20	4	Human	7.8	pKi	=	7.8	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/jm030205t
	49862237	14975	0	None	-11	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	CHEMBL1209157	14975	0	None	-11	3	Human	6.8	pKi	=	6.8	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	395	6	0	5	4.3	COc1ccc(OC)c(C2CCN(Cc3cnn(-c4ccccc4F)c3C)C2)c1	10.1016/j.bmcl.2010.06.033
	1524	2168	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	197	2168	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	3822	2168	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	88	2168	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	CHEMBL51	2168	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	DB12465	2168	96	None	-229	52	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 minsDisplacement of [3H]Lysergic acid from human recombinant 5HT2B receptor expressed in CHOK1 cells after 60 mins	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1016/j.bmcl.2013.01.025
	118055199	177931	0	None	-33	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	1.9	CC1(C)CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4645774	177931	0	None	-33	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	1.9	CC1(C)CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	44409124	74440	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	214	0	1	4	0.7	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL202795	74440	0	None	-30	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	214	0	1	4	0.7	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)nc3N12	10.1016/j.bmcl.2005.11.083
	46914777	15411	0	None	18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1215038	15411	0	None	18	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	33630	178933	99	None	-6	28	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL47050	178933	99	None	-6	28	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	44582677	181549	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476838	181549	0	None	1	3	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	432	10	1	6	3.9	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc([N+](=O)[O-])cc2)CC1	10.1016/j.bmc.2009.03.021
	71061729	160919	0	None	-1	4	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4115493	160919	0	None	-1	4	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	25117679	200581	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	CHEMBL599263	200581	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	142601318	185521	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4863036	185521	0	None	-12	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	134138183	147786	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3932820	147786	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	155567457	175925	0	None	-158	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	359	2	3	6	2.8	O[C@H]1CCC[C@@H]1Nc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
	CHEMBL4587951	175925	0	None	-158	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assayDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cell by radioligand binding assay	ChEMBL	359	2	3	6	2.8	O[C@H]1CCC[C@@H]1Nc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
	46914926	15399	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214960	15399	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	11579853	89056	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337504	89056	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365200	89056	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	230	1	2	2	1.4	CCc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	119584	2577	102	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	1848	2577	102	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	242	2577	102	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	CHEMBL60889	2577	102	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	DB11675	2577	102	None	1	6	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	nan
	CHEMBL4750687	214014	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000312b HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000312b HTR2B	ChEMBL		None	None	None		Cc1ncc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(CC(N)=O)c2cnccc21	10.6019/CHEMBL5212743
	CHEMBL4741904	214009	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000710a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000710a HTR2B	ChEMBL		None	None	None		Cc1ncc(-c2cc(Cl)ccc2F)cc1-n1c(=O)n(CC(N)=O)c2ccccc21	10.6019/CHEMBL5212743
	44316027	205499	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL80862	205499	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	236	4	1	3	2.5	CCSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	11658860	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	2941	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	4374	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL360328	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	DB04871	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1021/jm801354e
	CHEMBL5074880	214316	0	None	-1	9	Human	7.7	pKi	=	7.7	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCNCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	9899500	67860	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	CHEMBL191054	67860	0	None	-14	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	11391654	180501	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	180501	0	None	-2	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	24873384	182577	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4788223	182577	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	255	2	1	3	2.8	CC(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	134154065	152337	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3970041	152337	0	None	2	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	433	6	3	9	1.5	COC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	11020695	25482	1	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL135076	25482	1	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](N)Cc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	879244	28168	8	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	CHEMBL1373650	28168	8	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	271	1	3	5	2.3	Cc1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acsmedchemlett.8b00300
	10791286	35287	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	491	3	1	3	6.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(Br)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14368	35287	0	None	-9	2	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	491	3	1	3	6.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(Br)cc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10526616	39476	0	None	-15	3	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	430	4	1	5	4.9	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3)nc1)CC2	10.1021/jm990388c
	CHEMBL14726	39476	0	None	-15	3	Human	7.7	pKi	=	7.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	430	4	1	5	4.9	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3)nc1)CC2	10.1021/jm990388c
	44298229	101897	0	None	-31	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL301012	101897	0	None	-31	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	147653864	171537	0	None	19	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4464697	171537	0	None	19	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	267	0	1	2	2.7	C[C@@]12COc3c(Br)cccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	153061504	172786	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4513930	172786	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	2389	3306	118	None	-66	68	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	5073	3306	118	None	-66	68	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	96	3306	118	None	-66	68	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	CHEMBL85	3306	118	None	-66	68	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	DB00734	3306	118	None	-66	68	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm070516u
	2267	557	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	271	557	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	7121	557	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	CHEMBL639	557	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	DB00972	557	71	None	-10	7	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	10.1016/j.bmcl.2017.09.020
	44298118	193387	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	5	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL52592	193387	0	None	-1	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	5	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	12017599	195761	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	426	4	1	3	5.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(CCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55784	195761	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	426	4	1	3	5.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(CCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	72698088	103962	0	None	-954	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	421	6	0	4	5.4	Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	CHEMBL3093187	103962	0	None	-954	5	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	421	6	0	4	5.4	Fc1cccc2c1nc(OCC1CCN(CCCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	11175045	136516	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.9	CC(C)c1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL373695	136516	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.9	CC(C)c1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	135474338	189247	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL511879	189247	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	54761054	138056	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Positive allosteric modulation of 5-HT2B receptor (unknown origin)Positive allosteric modulation of 5-HT2B receptor (unknown origin)	ChEMBL	367	3	1	5	4.0	Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C	10.1016/j.bmcl.2016.01.021
	CHEMBL3765778	138056	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Positive allosteric modulation of 5-HT2B receptor (unknown origin)Positive allosteric modulation of 5-HT2B receptor (unknown origin)	ChEMBL	367	3	1	5	4.0	Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C	10.1016/j.bmcl.2016.01.021
	134149168	148222	0	None	-2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	297	2	0	2	3.6	CN1CC[C@H]2CC(=O)[C@H](Cc3ccccc3)[C@H]3CCC[C@@H]1[C@H]23	10.1016/j.bmcl.2016.10.065
	CHEMBL3936289	148222	0	None	-2	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	297	2	0	2	3.6	CN1CC[C@H]2CC(=O)[C@H](Cc3ccccc3)[C@H]3CCC[C@@H]1[C@H]23	10.1016/j.bmcl.2016.10.065
	11499800	89078	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337503	89078	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365465	89078	0	None	-2	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	216	0	2	2	1.1	Cc1cc(C)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	25117680	200612	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	434	4	1	6	4.1	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	CHEMBL599466	200612	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	434	4	1	6	4.1	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CC[C@@H](N)C3)ccc21	10.1021/jm901674f
	155536619	172177	0	None	-75	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	254	3	4	7	-2.3	NC(=O)c1ncn([C@H]2[C@H](O)[C@H](O)[C@]3(CO)C[C@H]23)n1	10.1021/acs.jmedchem.8b01662
	CHEMBL4473739	172177	0	None	-75	4	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	254	3	4	7	-2.3	NC(=O)c1ncn([C@H]2[C@H](O)[C@H](O)[C@]3(CO)C[C@H]23)n1	10.1021/acs.jmedchem.8b01662
	122178710	121350	0	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581255	121350	0	None	-8	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OCc1ccccc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	11290492	137976	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL376456	137976	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	218	1	1	3	0.8	COc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	5318	15544	49	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1200348	15544	49	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1221	15544	49	None	-1	13	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	1531	2253	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	3869	2253	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	7207	2253	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	CHEMBL429	2253	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	DB00598	2253	69	None	-16	16	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	nan
	124	2960	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	2032	2960	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	4636	2960	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	CHEMBL762	2960	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	DB00935	2960	47	None	-181	33	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	nan
	11416698	91078	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397902	91078	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	73349359	92514	0	None	-2	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
	CHEMBL2432051	92514	0	None	-2	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	341	6	1	4	2.9	COc1cc(CN[C@H]2C3C4CC5C6C4CC3C6C52)cc(OC)c1OC	10.1016/j.bmc.2013.07.045
	44582708	186814	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	CHEMBL489408	186814	0	None	-1	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	415	10	0	5	4.2	COc1ccc(CCN2CCC(C(=O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	3191	102831	97	None	-7	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	CHEMBL305660	102831	97	None	-7	25	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
	44414251	78044	0	None	-158	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	470	7	0	4	4.8	COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL210053	78044	0	None	-158	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	470	7	0	4	4.8	COc1ccc(N2CC=C(c3ccc(Br)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	44414070	79891	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	474	7	0	4	5.7	COc1ccc(C2=C(C)CN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL212482	79891	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	474	7	0	4	5.7	COc1ccc(C2=C(C)CN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	49850672	56356	0	None	-794	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1631532	56356	0	None	-794	9	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	404	5	1	5	4.1	COC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	44298021	194736	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	4	1	4	5.9	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C(C)C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL53793	194736	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	422	4	1	4	5.9	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C(C)C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	18931377	206452	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1cccc(Cl)c1	10.1016/S0960-894X(96)00503-3
	CHEMBL88193	206452	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1cccc(Cl)c1	10.1016/S0960-894X(96)00503-3
	18931150	206805	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1cc(Cl)ccc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL90470	206805	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1cc(Cl)ccc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	153287566	171156	0	None	-74	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4459009	171156	0	None	-74	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	278	1	0	2	4.0	CN1CC[C@H]2c3ccccc3N(c3ccccc3)C[C@]21C	10.1021/acsmedchemlett.9b00225
	11292350	87912	0	None	-79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	394	6	0	4	4.3	COc1ccc(N2Cc3cccc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234006	87912	0	None	-79	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	394	6	0	4	4.3	COc1ccc(N2Cc3cccc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11775262	88026	0	None	-125	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234532	88026	0	None	-125	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11430311	150023	0	None	-158	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	428	6	0	4	5.2	COc1ccc(N2C(=O)c3c(Cl)cccc3C2C)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395059	150023	0	None	-158	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	428	6	0	4	5.2	COc1ccc(N2C(=O)c3c(Cl)cccc3C2C)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11453704	150042	0	None	-79	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.4	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395072	150042	0	None	-79	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.4	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCCCCC1	10.1016/j.bmcl.2006.10.029
	11282335	150299	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)c(Cl)cc3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395297	150299	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.3	COc1ccc(N2Cc3cc(Cl)c(Cl)cc3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	11753782	12774	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL1188213	12774	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL535626	12774	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	419	6	0	5	4.2	COc1ccc(N2Cc3c(c4ccccc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	10458785	86733	0	None	-50	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232045	86733	0	None	-50	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4ccc(Cl)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	10346749	88378	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	487	6	0	5	5.5	COc1ccc(N2Cc3c(c4cc(Cl)c(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	CHEMBL234947	88378	0	None	-31	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	487	6	0	5	5.5	COc1ccc(N2Cc3c(c4cc(Cl)c(Cl)cc4n3C)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.034
	10390089	142336	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	436	6	0	5	5.2	COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL388882	142336	0	None	-125	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	436	6	0	5	5.2	COc1ccc(N2Cc3sc4ccccc4c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	44298138	195478	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(COc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55344	195478	0	None	-39	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(COc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	162660908	181396	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4763861	181396	0	None	1	2	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	294	4	1	3	4.0	Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	162669225	182740	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2cccc(Cl)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4790230	182740	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2cccc(Cl)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	10812577	99017	1	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3cccnc3)ccc1F)CC2	10.1021/jm990388c
	CHEMBL280322	99017	1	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(-c3cccnc3)ccc1F)CC2	10.1021/jm990388c
	10249573	207570	0	None	-199	11	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL94984	207570	0	None	-199	11	Human	5.7	pKi	=	5.7	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	386	5	0	3	4.1	CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	10237852	72375	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	411	7	0	6	3.6	COc1ccc(-n2ccn(-c3cccc(F)c3)c2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198712	72375	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	411	7	0	6	3.6	COc1ccc(-n2ccn(-c3cccc(F)c3)c2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	24887517	169015	0	None	-158	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL439504	169015	0	None	-158	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	476	7	0	4	5.6	COc1ccc(N2CCC(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	11191906	11735	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL1181665	11735	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	CHEMBL187928	11735	0	None	-39	12	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HTBinding affinity towards human 5-hydroxytryptamine receptor 2B expressed in HEK 293 cells using the radioligand [3H]5-HT	ChEMBL	537	12	1	3	7.3	O=C(/C=C/c1ccccc1)N(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)Cc1cccnc1	10.1016/j.bmcl.2005.06.024
	44298079	196300	0	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	346	3	1	4	4.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL56232	196300	0	None	-19	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	346	3	1	4	4.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccccc32)cn1	10.1016/s0960-894x(00)00364-4
	44298193	199355	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL59097	199355	0	None	-316	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	10433930	51059	0	None	-999	5	Human	5.7	pKi	=	5.7	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL157910	51059	0	None	-999	5	Human	5.7	pKi	=	5.7	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	449	5	2	5	3.9	COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	118278424	121986	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	256	3	1	4	2.9	O=c1cc(CCc2ccco2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3593951	121986	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	256	3	1	4	2.9	O=c1cc(CCc2ccco2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	24865725	188060	0	None	-3981	12	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human cloned 5HT2B receptorDisplacement of radioligand from human cloned 5HT2B receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	CHEMBL497963	188060	0	None	-3981	12	Human	5.7	pKi	=	5.7	Binding	Displacement of radioligand from human cloned 5HT2B receptorDisplacement of radioligand from human cloned 5HT2B receptor	ChEMBL	453	8	1	5	4.2	Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm8001444
	9892409	100923	0	None	-398	9	Human	5.7	pKi	=	5.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
	CHEMBL29410	100923	0	None	-398	9	Human	5.7	pKi	=	5.7	Binding	The compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandThe compound was tested for the binding affinity towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	505	5	1	6	5.3	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCCCC2C1	10.1016/s0960-894x(02)00172-5
	448537	160226	89	None	-21	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	CHEMBL411	160226	89	None	-21	25	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
	11957541	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	1229	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	147	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	170617	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	CHEMBL6616	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human 5-HT2B receptor by radioligand displacement assayBinding affinity to human 5-HT2B receptor by radioligand displacement assay	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1016/j.ejmech.2013.01.044
	11957541	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	1229	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	147	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	170617	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	CHEMBL6616	1446	40	None	-2	16	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)-DOI from human 5HT2B receptorDisplacement of [125I](+/-)-DOI from human 5HT2B receptor	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm2006782
	24826867	91066	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397890	91066	0	None	3	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	11323169	179943	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4746737	179943	0	None	-1	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	2	1	3	3.1	Cc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	2220	3112	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	27400	3112	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	93	3112	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	CHEMBL294951	3112	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	DB06153	3112	82	None	-1	14	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1016/j.bmc.2013.10.010
	118717217	120550	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343667	120550	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545762	120550	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	325	4	2	3	1.6	COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	72734862	106279	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3092754	106279	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
	CHEMBL3139079	106279	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	253	1	2	2	2.0	NC(N)=NC(=O)c1ccc2c(c1)oc1ccccc12	10.1016/j.bmc.2013.10.010
	44269058	31336	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/ml3003814
	CHEMBL14022	31336	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1021/ml3003814
	157	2056	7	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
	9840090	2056	7	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL134519	2056	7	None	-20	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	10.1021/acs.jmedchem.1c00726
	1043	1569	14	None	-22	29	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	149	1569	14	None	-22	29	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	8223	1569	14	None	-22	29	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL442	1569	14	None	-22	29	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00696	1569	14	None	-22	29	Human	8.7	pKi	=	8.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	10251906	67754	18	None	-186	7	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1021/acs.jmedchem.2c00633
	CHEMBL1908863	67754	18	None	-186	7	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1021/acs.jmedchem.2c00633
	CHEMBL482496	67754	18	None	-186	7	Human	8.6	pKi	=	8.6	Binding	Binding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysisBinding affinity to 5-HT2B (unknown origin) assessed as inhibition constant by liquid scintillation counter analysis	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1021/acs.jmedchem.2c00633
	72734867	106339	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
	CHEMBL3092757	106339	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
	CHEMBL3139241	106339	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Oc1ccccc1N2	10.1016/j.bmc.2013.10.010
	230	4088	25	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
	3045225	4088	25	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
	CHEMBL407909	4088	25	None	-2	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	243	3	1	4	2.7	CCc1oc2c(c1)c1c(cc2)cnn1C[C@@H](N)C	10.1016/j.bmc.2007.12.009
	67781610	166930	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	0	2	4.7	CN(C)CC/C=C1\c2ccc(Br)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	CHEMBL4287193	166930	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	0	2	4.7	CN(C)CC/C=C1\c2ccc(Br)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	16062910	97399	0	None	-6	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	329	3	1	3	3.7	Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL269974	97399	0	None	-6	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	329	3	1	3	3.7	Cc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	9839920	101681	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	316	2	2	3	4.4	Cn1ccc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	CHEMBL299498	101681	0	None	10	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	316	2	2	3	4.4	Cn1ccc2cc(NC(=O)Nc3ccnc4ccccc34)ccc21	10.1016/s0960-894x(01)00343-2
	146709966	175755	0	None	338	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4583909	175755	0	None	338	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	1042	1568	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	148	1568	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	443884	1568	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	CHEMBL119443	1568	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	DB01253	1568	23	None	-7	17	Human	8.6	pKi	=	8.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
	11536844	115096	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343672	115096	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	206	2476	16	None	-1	25	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	68848	2476	16	None	-1	25	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL12314	2476	16	None	-1	25	Human	8.6	pKi	=	8.6	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	10.1016/j.ejmech.2019.04.064
	4376990	192985	5	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5207529	192985	5	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5222754	192985	5	None	-1	11	Human	8.5	pKi	=	8.5	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	372	4	2	4	4.1	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(Cl)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	153061504	172786	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4513930	172786	0	None	15	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2c(ccc3ccccc23)OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	59752538	181128	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4760784	181128	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	339	3	1	4	3.7	CC(C)n1nc2c(c1-c1ccc(OC(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	11414582	181314	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4762886	181314	0	None	-3	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	271	2	1	3	2.7	Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	59752638	182373	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4785470	182373	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	253	2	1	3	2.6	c1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	189	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
	5163	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
	CHEMBL297784	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/acs.jnatprod.2c00365
	3037629	184548	18	None	1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4848517	184548	18	None	1	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	66647021	120650	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402656	120650	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547009	120650	0	None	-9	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	257	2	0	1	4.2	CN(C)[C@@H]1Cc2ccccc2[C@@H](C2CCCCC2)C1	10.1016/j.bmc.2015.01.060
	118729256	120683	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402670	120683	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547156	120683	0	None	6	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	16062785	95092	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	2	1	3	3.1	CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL255543	95092	0	None	-5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	2	1	3	3.1	CC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	16062784	95138	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	318	2	1	4	3.4	N#Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL255802	95138	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	318	2	1	4	3.4	N#Cc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	752521	198714	8	None	12	9	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	CHEMBL582877	198714	8	None	12	9	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	295	1	3	5	1.9	CC1(C)N=C(N)N=C(Nc2cccc(Br)c2)N1	10.1021/acs.jmedchem.5b01631
	118729260	120662	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402672	120662	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547044	120662	0	None	1	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	118729274	120685	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402681	120685	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547175	120685	0	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	44435219	91763	0	None	-6	4	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	367	2	0	2	6.2	O=C(Cc1ccc2ccccc2c1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL241115	91763	0	None	-6	4	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	367	2	0	2	6.2	O=C(Cc1ccc2ccccc2c1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	155556618	174453	0	None	-1905	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4554295	174453	0	None	-1905	5	Human	5.7	pKi	=	5.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	417	6	3	7	2.7	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)ncnc32)[C@H]2C[C@@]2(CCl)[C@H]1O	10.1021/acs.jmedchem.8b01662
	5897	105184	80	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	CHEMBL311469	105184	80	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	223	1	1	1	3.2	CC(=O)Nc1ccc2c(c1)Cc1ccccc1-2	nan
	9926401	140850	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140850	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140850	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	71459553	83667	10	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
	CHEMBL2205360	83667	10	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	406	7	0	4	5.3	COc1ccc2c(C)c(C(=O)N(CCCN3CCCCC3)c3ccccc3)oc2c1	10.1016/j.bmc.2012.09.044
	9926401	140850	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819556	140850	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819732	140850	0	None	-4	8	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	301	5	0	2	4.4	Fc1ccc(SCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	155554410	174370	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	331	2	2	5	0.6	Cc1cccc(C)c1N1C(=O)[C@H](CO)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4552298	174370	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	331	2	2	5	0.6	Cc1cccc(C)c1N1C(=O)[C@H](CO)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	11615459	199225	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590078	199225	0	None	10	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	122186881	122955	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3608451	122955	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	11209786	137215	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375170	137215	0	None	-6	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	296	1	1	2	2.7	O=C1c2c(cc(C3CC3)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	155558626	174737	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4561016	174737	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	11336079	83447	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	280	0	1	2	1.8	C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL220115	83447	0	None	-6	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	280	0	1	2	1.8	C#Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	11264955	204938	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76474	204938	0	None	-6	3	Human	7.7	pKi	=	7.7	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	240	3	1	3	2.3	CSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	20824945	67558	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL190124	67558	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	196129	67769	17	None	-26	15	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	CHEMBL1909065	67769	17	None	-26	15	Human	7.7	pKi	=	7.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
	118055334	177446	0	None	-34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	266	0	1	2	2.5	CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4639090	177446	0	None	-34	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	266	0	1	2	2.5	CC1CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	24826963	91086	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397910	91086	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	0	1	2	1.3	Cc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	71681897	91090	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	CHEMBL2397914	91090	0	None	1	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	258	0	1	3	1.0	O=C1c2ccc3c(c2C[C@@H]2CNCCN12)OCCC3	10.1016/j.bmcl.2013.04.061
	25123014	200408	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL598229	200408	0	None	-6	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	126769	206019	42	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
	CHEMBL536255	206019	42	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
	CHEMBL85194	206019	42	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	2	3	3.2	Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc21	10.1016/j.bmcl.2016.05.079
	189	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
	5163	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
	CHEMBL297784	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C4MD00418C
	127037059	136512	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3736516	136512	0	None	10	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	445	11	0	5	5.6	COc1ccc(CCN(CC/C=C\c2ccccc2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL4777443	214023	0	None	11	14	Human	7.7	pKi	=	7.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR2B	ChEMBL		None	None	None		CC(C)(C)OC(=O)N1CCCC1CN[C@H]1CC[C@@](c2cc(F)ccc2F)(S(=O)(=O)c2ccc(Cl)cc2)CC1	10.6019/CHEMBL5212743
	70687202	77949	0	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	CHEMBL2096809	77949	0	None	-10	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@@H]1CNC[C@@H]2Cc3ccccc3N21	10.1016/j.bmcl.2005.05.074
	18715558	73853	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL201897	73853	0	None	-5	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3ccncc3c21	10.1016/j.bmcl.2005.10.029
	44451390	155726	2	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	210	1	2	2	2.1	CNc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL405717	155726	2	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	210	1	2	2	2.1	CNc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	118729246	120661	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402663	120661	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547043	120661	0	None	-2	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	16062143	97666	0	None	-19	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	283	2	1	3	3.2	Fc1ccc(-c2nc(C3CCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271318	97666	0	None	-19	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	283	2	1	3	3.2	Fc1ccc(-c2nc(C3CCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	134146585	148885	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	366	3	3	8	-0.4	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3941738	148885	0	None	2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	366	3	3	8	-0.4	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	117209911	186305	1	None	-26	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4874854	186305	1	None	-26	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccccc1-c1n[nH]cc1N1CCNCC1	10.1021/acs.jmedchem.1c01093
	24826786	91057	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397881	91057	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	10330266	21371	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2ccsc12	10.1021/jm980692q
	CHEMBL13147	21371	0	None	-3	4	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from cloned human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2ccsc12	10.1021/jm980692q
	4011	82379	49	None	-20	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	CHEMBL21731	82379	49	None	-20	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
	155512086	169597	0	None	-407	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	399	6	4	8	1.5	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4436786	169597	0	None	-407	5	Human	6.7	pKi	=	6.7	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	399	6	4	8	1.5	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	137645406	157878	0	None	-269	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4084262	157878	0	None	-269	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	491	8	0	7	5.4	COc1ccccc1N1CCC2(CCN(CCCSc3nnc(-c4ccccc4)n3C)CC2)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4526351	213960	0	None	-1	4	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000703a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000703a HTR2B	ChEMBL		None	None	None		Cc1cc(NC(=O)c2cccc(S(F)(F)(F)(F)F)c2)cc(-n2ccn3nc(-c4cccnc4)cc23)c1	10.6019/CHEMBL5212743
	117209857	185114	1	None	-5	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4856702	185114	1	None	-5	8	Human	6.7	pKi	=	6.7	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	4601	206724	35	None	-4	17	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL1201023	206724	35	None	-4	17	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	CHEMBL900	206724	35	None	-4	17	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	nan
	68617	205504	62	None	-15	26	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL1709	205504	62	None	-15	26	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	CHEMBL809	205504	62	None	-15	26	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	nan
	104697662	145380	1	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	CHEMBL3914002	145380	1	None	1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	293	3	2	4	3.3	Clc1cccc(CNc2nc(Cl)nc3[nH]cnc23)c1	10.1021/acs.jmedchem.6b01183
	71682217	91089	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397913	91089	0	None	1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	1	1	3	1.0	COc1c(C)ccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44409032	74993	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@@H]2Cc3ccc(Cl)nc3N21	10.1016/j.bmcl.2005.11.083
	CHEMBL203396	74993	0	None	-4	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@@H]2Cc3ccc(Cl)nc3N21	10.1016/j.bmcl.2005.11.083
	165193	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3165	68	None	-72	43	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2353	101085	82	None	-7	5	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL12089	101085	82	None	-7	5	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	CHEMBL295124	101085	82	None	-7	5	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	336	2	0	4	3.1	COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2	nan
	10440	2662	20	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2662	20	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2662	20	None	3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	3117	207818	103	None	-8	16	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	CHEMBL964	207818	103	None	-8	16	Human	4.7	pKi	=	4.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
	145992489	166953	0	None	-6	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4287623	166953	0	None	-6	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	535	7	1	2	7.8	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	118055195	177993	0	None	-9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	2.0	Cc1ccc2c3c1C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4646618	177993	0	None	-9	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	202	0	1	2	2.0	Cc1ccc2c3c1C(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	122178704	121344	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581249	121344	0	None	1	5	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	16047544	12616	8	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL1187185	12616	8	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	CHEMBL492916	12616	8	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	225	2	1	1	2.5	NCC1CC1c1ccccc1Br	10.1021/jm801354e
	16062911	97683	0	None	-27	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	383	3	1	3	4.4	FC(F)(F)c1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271418	97683	0	None	-27	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	383	3	1	3	4.4	FC(F)(F)c1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	189	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
	5163	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
	CHEMBL297784	3466	39	None	-5	17	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1039/C8MD00204E
	11658860	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	2941	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	4374	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	CHEMBL360328	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	DB04871	2329	51	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	10.1016/j.bmcl.2019.126929
	11187156	136329	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL373483	136329	0	None	-3	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	312	3	1	2	3.1	CCCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	16062270	97645	0	None	-100	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	297	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271212	97645	0	None	-100	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	297	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	16062266	97665	0	None	-169	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	337	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271317	97665	0	None	-169	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	337	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	2284	3160	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	4926	3160	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	7281	3160	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	CHEMBL564	3160	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	DB00420	3160	33	None	-16	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
	9837204	74664	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	209	0	1	3	1.1	Clc1ccc2c(n1)N1CCNCC1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL203025	74664	1	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	209	0	1	3	1.1	Clc1ccc2c(n1)N1CCNCC1C2	10.1016/j.bmcl.2005.11.083
	49865829	16127	0	None	22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	330	1	1	3	4.1	O=C(Nc1ccccc1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224031	16127	0	None	22	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	330	1	1	3	4.1	O=C(Nc1ccccc1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	51352628	82798	10	None	-1	3	Human	5.7	pKi	=	5.7	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	CHEMBL2180408	82798	10	None	-1	3	Human	5.7	pKi	=	5.7	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	16062139	157643	0	None	-204	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.4	CCC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL408154	157643	0	None	-204	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.4	CCC(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	71463061	83766	0	None	-3	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	CHEMBL2205813	83766	0	None	-3	9	Human	5.7	pKi	=	5.7	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	339	5	1	4	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1OC	10.1016/j.bmcl.2012.08.046
	2351	3261	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	2820	3261	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	5035	3261	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	CHEMBL81	3261	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	DB00481	3261	64	None	-7	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
	156012918	177424	0	None	-7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.2	Clc1ccc2c3c1CCCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4638807	177424	0	None	-7	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.2	Clc1ccc2c3c1CCCN3CCNC2	10.1016/j.bmcl.2019.126929
	24826870	91074	0	None	-4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397898	91074	0	None	-4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	444795	139974	105	None	3	2	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	CHEMBL38	139974	105	None	3	2	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	nan
	136118613	93034	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442275	93034	0	None	5	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	51352628	82798	10	None	-1	3	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	CHEMBL2180408	82798	10	None	-1	3	Human	5.6	pKi	=	5.6	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	353	5	0	7	2.1	COCCc1ccc(-c2c(C)nc3c(N4CCOCC4)ccnn23)cn1	10.6019/CHEMBL4800727
	CHEMBL5271021	193643	0	None	11	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1039/D1MD00167A
	26987	946	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	6063	946	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	671	946	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	CHEMBL1626	946	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	DB00283	946	33	None	-47	21	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
	46230099	199289	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590483	199289	0	None	-2	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CCNCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	11514226	89081	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337494	89081	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365470	89081	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	202	0	2	2	0.8	Cc1cccc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	15560577	185317	9	None	1	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4859858	185317	9	None	1	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in CHO cells by radioligand completion assay relative to control	ChEMBL	398	5	1	5	3.8	CC[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	134152052	153059	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3976121	153059	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	134152052	153059	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL3976121	153059	0	None	3	5	Human	7.6	pKi	=	7.6	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	432	6	4	8	1.1	CNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL5094493	215476	0	None	-11	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCN(CCC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	72698087	103961	0	None	-2089	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	407	5	0	4	5.0	Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	CHEMBL3093186	103961	0	None	-2089	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2BBinding affinity to human 5HT2B	ChEMBL	407	5	0	4	5.0	Fc1cccc2c1nc(OCC1CCN(CCC(F)(F)F)CC1)c1cccnc12	10.1016/j.bmc.2013.08.061
	10251906	67754	18	None	-186	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1016/j.bmc.2008.04.050
	CHEMBL1908863	67754	18	None	-186	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1016/j.bmc.2008.04.050
	CHEMBL482496	67754	18	None	-186	7	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	427	8	1	4	3.6	COc1cc(CCNCc2ccccc2OC)c(OC)cc1I	10.1016/j.bmc.2008.04.050
	155539605	172821	0	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4514672	172821	0	None	3	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	313	1	0	4	2.1	CC1=NC2(CCN(C)CC2)C(=O)N(c2c(C)cccc2C)C1=O	10.1016/j.ejmech.2018.12.048
	127034730	136414	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735643	136414	0	None	9	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	523	14	0	8	5.1	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	46914927	15387	0	None	14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214893	15387	0	None	14	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	382	8	0	4	4.5	FCCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	91864602	140713	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140713	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	135514796	93029	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	226	1	4	2	1.2	N=C1NC(=O)/C(=C\c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442270	93029	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	226	1	4	2	1.2	N=C1NC(=O)/C(=C\c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	142601323	185817	0	None	-9	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	CHEMBL4867560	185817	0	None	-9	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1ccccc1-c1n[nH]cc1N1CCCNCC1	10.1021/acs.jmedchem.1c01093
	3973	208157	110	None	-44	3	Human	4.6	pKi	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	CHEMBL98350	208157	110	None	-44	3	Human	4.6	pKi	=	4.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	307	2	0	4	3.3	O=c1cc(N2CCOCC2)oc2c(-c3ccccc3)cccc12	nan
	3157	1458	71	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	7170	1458	71	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	954	1458	71	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	CHEMBL707	1458	71	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	DB00590	1458	71	None	-37	12	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	nan
	91864602	140713	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818047	140713	0	None	-66	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	313	5	0	2	4.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(Cl)cc1	10.1016/j.bmc.2016.05.053
	16115388	137341	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL375302	137341	0	None	-2	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	1	1	2	2.6	CC[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	11185858	84763	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL223271	84763	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	71061785	160472	0	None	-6	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	CHEMBL4112056	160472	0	None	-6	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	386	5	0	4	3.0	O=C(CN1CCO[C@@H](COc2cccc(Cl)c2)C1)N1CCc2ccccc21	nan
	10430623	18643	24	None	-213	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	CHEMBL1277105	18643	24	None	-213	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	392	3	2	5	3.0	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(N3CCNCC3)cc12	10.1021/jm1007825
	72901200	119751	25	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2BSelectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2B	ChEMBL	322	7	2	4	3.8	Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1	10.6019/CHEMBL5212743
	CHEMBL3480577	119751	25	None	-162	4	Human	6.6	pKi	=	6.6	Binding	Selectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2BSelectivity interaction (PRESTO-Tango GPCR-ome screening) EUB0000539a HTR2B	ChEMBL	322	7	2	4	3.8	Cc1ccc2nc(CNCCCOc3ccccc3)cc(O)c2c1	10.6019/CHEMBL5212743
	11587397	89027	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337489	89027	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364893	89027	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	6726	1269	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	7151	1269	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	749	1269	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL648	1269	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB01176	1269	51	None	-7	13	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	44579715	193228	0	None	-2238	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	4	3	7	2.7	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Cl)c3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	CHEMBL523797	193228	0	None	-2238	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	405	4	3	7	2.7	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NCc3cccc(Cl)c3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	46230048	199267	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590332	199267	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	118055215	177432	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	216	0	1	2	2.2	Cc1ccc2c3c1C(C)(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4638879	177432	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	216	0	1	2	2.2	Cc1ccc2c3c1C(C)(C)CN3CCNC2	10.1016/j.bmcl.2019.126929
	1355	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	142	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	CHEMBL478	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	DB12110	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2009.12.014
	11652452	89097	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337492	89097	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365703	89097	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	270	0	1	2	1.8	CN1C(=O)c2c(cccc2C(F)(F)F)[C@H]2CNC[C@@H]21	10.1016/j.bmcl.2012.10.091
	162668650	182649	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4789085	182649	0	None	-7	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	284	3	2	4	2.9	CNc1ccc(-c2c3c(nn2C(C)C)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	3251	4041	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	5684	4041	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	80	4041	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	CHEMBL31354	4041	58	None	-79	12	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	422	7	0	5	3.8	COc1ccccc1N1CCN(CC1)CCN(C(=O)C1CCCCC1)c1ccccn1	10.1016/j.ejmech.2011.06.023
	1355	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	142	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	CHEMBL478	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	DB12110	1998	88	None	-1	16	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1021/jm0612968
	16115381	83414	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	CHEMBL219837	83414	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1NCCN2C(=O)c3c(cccc3C(F)(F)F)[C@H]12	10.1021/jm0612968
	10015055	2090	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	1212	2090	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	CHEMBL3402679	2090	4	None	-120	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@H]1Cc2ccccc2[C@@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	46884100	7985	0	None	-104	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1090757	7985	0	None	-104	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	314	5	2	3	3.0	O=C(NCc1ccc(Oc2cccc(F)c2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	145978665	163494	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4202582	163494	0	None	1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	246	2	2	3	2.4	C[C@@H]1SC(c2c[nH]c3ccccc23)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	2142	3074	58	None	-43	37	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	4920903	3074	58	None	-43	37	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	502	3074	58	None	-43	37	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	5775	3074	58	None	-43	37	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	CHEMBL597	3074	58	None	-43	37	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	DB00692	3074	58	None	-43	37	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	nan
	56678761	65638	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1cccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834257	65638	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1cccc(CCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	46914773	15397	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214958	15397	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	9921064	127152	25	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	CHEMBL365751	127152	25	None	-8	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	236	3	1	1	3.2	Cc1[nH]c2ccc(Cl)cc2c1CCN(C)C	10.1021/acs.jmedchem.5b00179
	22254068	65940	32	None	-173	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	423	5	2	6	4.0	CS(=O)(=O)NC[C@H]1CC[C@H](Nc2nc3c(s2)CCSc2ccccc2-3)CC1	10.1016/j.bmcl.2011.06.124
	CHEMBL1836317	65940	32	None	-173	4	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	423	5	2	6	4.0	CS(=O)(=O)NC[C@H]1CC[C@H](Nc2nc3c(s2)CCSc2ccccc2-3)CC1	10.1016/j.bmcl.2011.06.124
	11536299	183262	8	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	CHEMBL479683	183262	8	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	266	3	1	3	3.3	O=c1cc(CCc2ccccc2)oc2cccc(O)c12	10.1016/j.bmcl.2014.02.029
	145990586	166819	0	None	-19	11	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	CHEMBL4285281	166819	0	None	-19	11	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition of radioligand binding by radioligand competition binding assay	ChEMBL	297	2	2	4	2.6	COc1cc2c3c(c1OC)-c1ccccc1[C@@H](O)[C@@H]3NCC2	10.1039/C7MD00656J
	136118660	76227	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058428	76227	0	None	-1	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	135367816	164811	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218801	164811	0	None	-3	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	248	1	1	3	2.7	Clc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	11483068	84783	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223440	84783	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	11414184	83469	0	None	-13	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	CHEMBL220274	83469	0	None	-13	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)C2CNCCN12	10.1021/jm0612968
	43922	114739	10	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	250	4	2	2	2.0	COc1cc2c(CCNC(C)=O)c[nH]c2cc1F	10.1021/jm100600y
	CHEMBL333886	114739	10	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	250	4	2	2	2.0	COc1cc2c(CCNC(C)=O)c[nH]c2cc1F	10.1021/jm100600y
	1212	1649	50	None	-27	66	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	204	1649	50	None	-27	66	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	3372	1649	50	None	-27	66	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	CHEMBL726	1649	50	None	-27	66	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	DB00623	1649	50	None	-27	66	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
	9856509	95938	4	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	259	0	1	1	2.8	Clc1c(Br)ccc2c1CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL259480	95938	4	None	-10	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	259	0	1	1	2.8	Clc1c(Br)ccc2c1CCNCC2	10.1016/j.bmc.2007.12.009
	168293016	192086	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5203303	192086	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	7	0	5	5.0	CCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	10599545	36372	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14469	36372	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Cl)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10436045	3490	4	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	782	3490	4	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	CHEMBL432713	3490	4	None	-7	13	Human	7.6	pKi	=	7.6	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	499	9	3	3	6.4	O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2	10.1016/s0960-894x(01)00397-3
	189	3466	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
	5163	3466	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
	CHEMBL297784	3466	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970741j
	11391654	180501	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4753511	180501	0	None	-2	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	273	2	1	3	3.0	CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	189	3466	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
	5163	3466	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
	CHEMBL297784	3466	39	None	-5	17	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cellsDisplacement of [3H]5-HT from 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm970424c
	10835537	38597	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2	10.1021/jm990388c
	CHEMBL14652	38597	0	None	-5	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccccc3)c1)CC2	10.1021/jm990388c
	10574607	40614	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	CHEMBL14841	40614	0	None	-7	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3ccncc3)c1)CC2	10.1021/jm990388c
	44298249	194561	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3cccnc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL53063	194561	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3cccnc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	44298121	194805	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cccc(COc2ccc(NC(=O)N3CCc4cc(C)c(C(F)(F)F)cc43)cn2)n1	10.1016/s0960-894x(00)00365-6
	CHEMBL53939	194805	0	None	-3	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cccc(COc2ccc(NC(=O)N3CCc4cc(C)c(C(F)(F)F)cc43)cn2)n1	10.1016/s0960-894x(00)00365-6
	44214723	195471	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	427	4	1	3	5.6	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)cc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55335	195471	0	None	-10	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	427	4	1	3	5.6	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)cc1)CC2	10.1016/s0960-894x(00)00365-6
	1225	1459	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	3958	1459	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	667477	1459	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	CHEMBL860	1459	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	DB01142	1459	26	None	-89	22	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	10.1021/acsmedchemlett.8b00300
	20824946	123617	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	218	1	2	3	0.9	C[C@@H]1CNC[C@H]2Cc3ccc(CO)cc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL361929	123617	0	None	-7	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	218	1	2	3	0.9	C[C@@H]1CNC[C@H]2Cc3ccc(CO)cc3N12	10.1016/j.bmcl.2005.05.074
	118729244	120660	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402662	120660	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547029	120660	0	None	-1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	122188579	123158	0	None	-1479	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	471	4	4	8	2.0	CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.5b00150
	CHEMBL3612940	123158	0	None	-1479	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	471	4	4	8	2.0	CCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.5b00150
	16062137	97684	0	None	-125	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271419	97684	0	None	-125	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	44298186	101684	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	458	4	1	5	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cc1C)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL299506	101684	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	458	4	1	5	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cc1C)CC2	10.1016/s0960-894x(00)00364-4
	44298120	194977	0	None	-158	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1ccc2c(c1Br)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	CHEMBL54775	194977	0	None	-158	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1ccc2c(c1Br)CCN2C(=O)Nc1ccc(Oc2cccnc2C)nc1	10.1016/s0960-894x(00)00364-4
	44323840	206549	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	9	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL88809	206549	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	586	12	3	9	2.7	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	155519891	170369	0	None	2	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4447975	170369	0	None	2	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	249	2	1	4	1.9	COc1cc(OC)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	155526977	171097	0	None	10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	221	2	1	3	2.3	CC[C@H]1c2cc(OC)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4458099	171097	0	None	10	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	221	2	1	3	2.3	CC[C@H]1c2cc(OC)ccc2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	153287541	172171	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4473697	172171	0	None	-12	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	279	1	0	2	3.9	CN1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	153287539	176050	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591008	176050	0	None	3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	265	1	1	2	3.6	C[C@@]12COc3ccc(-c4ccccc4)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11465413	88014	0	None	-125	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.7	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234494	88014	0	None	-125	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.7	COc1ccc(N2Cc3cc(Cl)cc(Cl)c3C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.10.029
	11305844	88147	0	None	-630	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	466	6	0	4	5.1	COc1ccc(N2Cc3cc(F)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL234739	88147	0	None	-630	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	466	6	0	4	5.1	COc1ccc(N2Cc3cc(F)cc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10368204	86735	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4ccc(F)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232047	86735	0	None	-15	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4ccc(F)cc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	2337	3232	77	None	-15	63	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	50	3232	77	None	-15	63	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	5002	3232	77	None	-15	63	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	CHEMBL716	3232	77	None	-15	63	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	DB01224	3232	77	None	-15	63	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm070516u
	76325516	105704	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	280	4	1	3	3.7	O=c1cc(CCCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	CHEMBL3126299	105704	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranesDisplacement of [3H]LSD from human 5HT2B receptor expressed in stable HEK cells membranes	ChEMBL	280	4	1	3	3.7	O=c1cc(CCCc2ccccc2)oc2cccc(O)c12	10.1021/acs.jnatprod.5b00118
	18357724	196574	0	None	-31	3	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2ccc(C(F)(F)F)cc21	10.1016/s0960-894x(00)00365-6
	CHEMBL56405	196574	0	None	-31	3	Human	6.6	pKi	=	6.6	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2ccc(C(F)(F)F)cc21	10.1016/s0960-894x(00)00365-6
	162645563	179666	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2ccc(C(F)(F)F)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4743625	179666	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	348	4	1	3	4.7	O=c1cc(CCCc2ccc(C(F)(F)F)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	162648564	179897	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2ccc(Cl)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4746138	179897	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	314	4	1	3	4.3	O=c1cc(CCCc2ccc(Cl)cc2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	162666438	182246	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	298	4	1	3	3.8	O=c1cc(CCCc2cccc(F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	CHEMBL4783824	182246	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	298	4	1	3	3.8	O=c1cc(CCCc2cccc(F)c2)oc2cccc(O)c12	10.1016/j.bmcl.2020.127511
	44298126	101568	0	None	-158	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c(Cl)cccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL298696	101568	0	None	-158	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c(Cl)cccc32)cn1	10.1016/s0960-894x(00)00364-4
	10085260	170603	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	CHEMBL445106	170603	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]- rauwolscine as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	71086303	160786	0	None	1	2	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4114493	160786	0	None	1	2	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	117209965	185223	1	None	-10	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4858338	185223	1	None	-10	6	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	46914775	15398	0	None	3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214959	15398	0	None	3	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	127035062	136426	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3735756	136426	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	127035062	136426	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735756	136426	0	None	-4	19	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	15011385	161528	4	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	CHEMBL412876	161528	4	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	244	3	1	2	2.6	CN(C)CCc1c[nH]c2ccc3c(c12)CCCO3	10.1021/jm030205t
	45378936	199483	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	448	5	1	6	4.2	CC(C)Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	CHEMBL591940	199483	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	448	5	1	6	4.2	CC(C)Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	70695555	77932	1	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@H]1CNC[C@@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL2096711	77932	1	None	-14	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	188	0	1	2	1.4	C[C@H]1CNC[C@@H]2Cc3ccccc3N12	10.1016/j.bmcl.2005.05.074
	168286277	191591	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	468	3	2	3	6.5	Ic1ccc(Nc2nc3ccccc3c3[nH]c(C4CCCCC4)nc23)cc1	10.1021/acs.jmedchem.2c01170
	CHEMBL5195535	191591	0	None	-3	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	468	3	2	3	6.5	Ic1ccc(Nc2nc3ccccc3c3[nH]c(C4CCCCC4)nc23)cc1	10.1021/acs.jmedchem.2c01170
	1599	2326	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	3955	2326	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	7215	2326	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	CHEMBL841	2326	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	DB00836	2326	50	None	-144	16	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	nan
	46914771	15379	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214831	15379	0	None	12	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	165193	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	2303	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4946	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	564	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	62882	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	63	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	66366	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	91536	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL27	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	CHEMBL452861	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	DB00571	3165	68	None	-72	43	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	nan
	4209	3141	75	None	-758	34	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	4893	3141	75	None	-758	34	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	503	3141	75	None	-758	34	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	5385	3141	75	None	-758	34	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	CHEMBL2	3141	75	None	-758	34	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	DB00457	3141	75	None	-758	34	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	nan
	10085260	170603	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	CHEMBL445106	170603	0	None	-66	5	Human	6.6	pKi	=	6.6	Binding	Binding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligandBinding ability of compound at cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT 2B as radioligand	ChEMBL	283	1	1	3	2.2	COc1cc(Br)c2c3c1C[C@H](N)C[C@@H]3CO2	10.1021/jm980076u
	135433933	177014	1	None	-2	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL463249	177014	1	None	-2	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cc(Br)ccc23)C1=O	10.1016/j.bmc.2013.09.011
	136118728	93032	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442273	93032	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1	10.1016/j.bmc.2013.09.011
	90181059	160207	0	None	-1	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4109801	160207	0	None	-1	4	Mouse	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	382	6	0	5	2.4	COc1cccc(OC[C@H]2CN(CC(=O)N3CCc4ccccc43)CCO2)c1	nan
	10472143	119251	0	None	-60	16	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL343755	119251	0	None	-60	16	Human	7.6	pKi	=	7.6	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	59757153	106316	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
	CHEMBL3092762	106316	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
	CHEMBL3139190	106316	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	251	1	2	1	1.7	NC(N)=NC(=O)c1cccc2c1-c1ccccc1C2	10.1016/j.bmc.2013.10.010
	118464427	138309	0	None	15	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3771331	138309	0	None	15	7	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	328	3	4	6	1.8	CCNC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	118709750	113513	0	None	-24	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321791	113513	0	None	-24	9	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1cccc(F)c1	10.1016/j.bmcl.2014.07.018
	44453652	155431	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	1	1	3	2.8	Cc1nc2c(c(-c3ccc(Cl)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL403902	155431	0	None	4	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	273	1	1	3	2.8	Cc1nc2c(c(-c3ccc(Cl)cc3)n1)CCNCC2	10.1016/j.bmcl.2008.01.090
	73349361	92519	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL2432058	92519	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	279	4	0	1	3.3	CN(CCc1ccccc1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	136118636	76285	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	CHEMBL2058696	76285	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cc(Br)ccc12	10.1016/j.bmc.2013.09.011
	43229249	140792	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140792	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	25067564	201277	0	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL604102	201277	0	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	392	3	2	5	3.1	N[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	56658157	65639	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	348	7	0	3	4.6	c1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834258	65639	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	348	7	0	3	4.6	c1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	43229249	140792	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818989	140792	1	None	-70	8	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	279	5	0	2	3.7	O=C(CCCN1CCc2ccccc2C1)c1ccccc1	10.1016/j.bmc.2016.05.053
	44582706	186973	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	417	10	1	5	4.0	COc1ccc(CCN2CCC(C(O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	CHEMBL490633	186973	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	417	10	1	5	4.0	COc1ccc(CCN2CCC(C(O)c3cccc(OCCF)c3OC)CC2)cc1	10.1016/j.bmc.2009.03.021
	3035850	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
	457	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
	CHEMBL431733	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
	DB12885	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1039/D1MD00167A
	3035850	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	457	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	CHEMBL431733	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	DB12885	948	73	None	-15135	14	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	544	5	4	9	1.1	CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I	10.1021/acs.jmedchem.6b01183
	145973771	164695	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	CHEMBL4217398	164695	0	None	-3	7	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK293 cell membranes after 90 mins by scintillation counting method	ChEMBL	797	16	2	7	10.8	CC(C)(C)OC(=O)NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
	21138	98423	39	None	-6	7	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	CHEMBL275742	98423	39	None	-6	7	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	259	6	2	3	2.6	CC(C)NC[C@@H](O)COc1cccc2ccccc12	nan
	46914486	15388	0	None	13	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214894	15388	0	None	13	3	Human	7.6	pKi	=	7.6	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	124087	1377	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	7157	1377	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	814	1377	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	CHEMBL1172	1377	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	DB00967	1377	114	None	-5	15	Human	7.6	pKi	=	7.6	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	nan
	118055191	177291	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	280	0	1	2	2.7	CC1(C)CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4636977	177291	0	None	-31	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	280	0	1	2	2.7	CC1(C)CN2CCNCc3ccc(Br)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL5074190	214291	0	None	-112	9	Human	6.6	pKi	=	6.6	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(CCN(C)C)ccc1Cl	10.1021/acs.jmedchem.1c00110
	11701315	199266	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590331	199266	0	None	1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)N1CCNCC1NC2=O	10.1016/j.bmcl.2009.12.014
	44554393	18515	0	None	-61	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	448	5	1	6	4.1	CC(C)Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	CHEMBL1275630	18515	0	None	-61	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	448	5	1	6	4.1	CC(C)Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	CHEMBL4748908	214012	1	None	-3	12	Human	6.6	pKi	=	6.6	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
	49783415	17646	0	None	-3890	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
	CHEMBL1258452	17646	0	None	-3890	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	320	7	1	5	2.9	CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1	10.1021/jm100668r
	136118647	76291	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.2	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058702	76291	0	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.2	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccccc23)N1	10.1016/j.bmc.2013.09.011
	1530	2169	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	3827	2169	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	7206	2169	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	CHEMBL534	2169	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	DB00920	2169	50	None	-19	21	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
	122178707	121347	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581252	121347	0	None	-1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OCC1CC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	11233293	84133	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
	CHEMBL220833	84133	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	310	1	1	2	2.9	CC1(c2cc3c(c(C(F)(F)F)c2)C(=O)N2CCNC[C@@H]32)CC1	10.1021/jm0612968
	16115267	84764	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL223272	84764	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	71461049	82946	0	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181187	82946	0	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	364	6	0	4	4.9	CCCN1CCC(COc2nc3c(OC)cccc3c3ccccc23)CC1	10.1021/jm300943r
	56665074	65634	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1cccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834253	65634	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1cccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	CHEMBL4748908	214012	1	None	-3	12	Human	6.5	pKi	=	6.5	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CN1CCN(c2ccnc(NCCc3ccccc3)n2)CC1	10.6019/CHEMBL4800732
	155534799	176488	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
	CHEMBL4471059	176488	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
	CHEMBL4596904	176488	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysisDisplacement of [125I](+/-)DOI from recombinant human 5-HT2B receptor after 60 mins by radiometric scintillation analysis	ChEMBL	416	7	1	6	2.7	O=c1c2cc(Cl)ccc2oc2ccc(CN3CCN(CCOCCO)CC3)cc12	10.1016/j.bmcl.2019.126679
	155535203	172017	0	None	-7	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	CHEMBL4471712	172017	0	None	-7	6	Human	5.5	pKi	=	5.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	403	5	3	7	2.8	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CCC3)C3CCC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	5353853	17954	47	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	9556529	17954	47	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1262	17954	47	None	-23	15	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	44409327	76603	0	None	-128	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL206394	76603	0	None	-128	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	261	3	1	4	1.9	CCO[C@@H](C)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	155531067	171595	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4465512	171595	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	71459604	83764	0	None	-5	14	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	CHEMBL2205811	83764	0	None	-5	14	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1cccc(CCN2C3C4C5CC6C7C5C3C7C2(O)C64)c1	10.1016/j.bmcl.2012.08.046
	122187378	123000	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609143	123000	0	None	8	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	455	5	0	5	5.6	COc1cc2c3c(c1OCC1CC1)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	44455426	155125	0	None	-4	12	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL402143	155125	0	None	-4	12	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	11288612	182587	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4788327	182587	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	267	2	1	3	3.0	c1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	145981805	166686	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	313	3	0	2	4.6	CN(C)CC/C=C1\c2ccc(Cl)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	CHEMBL4282729	166686	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	313	3	0	2	4.6	CN(C)CC/C=C1\c2ccc(Cl)cc2COc2ccccc21	10.1021/acsmedchemlett.8b00300
	127048334	140575	1	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813796	140575	1	None	13	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccccc2Cl)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	135398737	955	93	None	-2	92	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	38	955	93	None	-2	92	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	722	955	93	None	-2	92	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	CHEMBL42	955	93	None	-2	92	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	DB00363	955	93	None	-2	92	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm070516u
	29943048	67633	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL190699	67633	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	29943048	67633	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL190699	67633	0	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	1588	2311	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	28864	2311	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	43	2311	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	CHEMBL157138	2311	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	DB00589	2311	27	None	-6	44	Human	8.5	pKi	=	8.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
	11637931	120557	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343665	120557	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545814	120557	0	None	-2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	2	2	2.0	COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	145993540	167310	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting method	ChEMBL	503	12	3	11	2.2	NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1	10.1039/C7MD00247E
	CHEMBL4294350	167310	0	None	-1	5	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEKT cells after 90 mins by scintillation counting method	ChEMBL	503	12	3	11	2.2	NCCCCNC(=O)COc1ccc(CCCn2ncc3c2nc(N)n2nc(-c4ccco4)nc32)cc1	10.1039/C7MD00247E
	127048335	140567	1	None	15	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813726	140567	1	None	15	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccccc2Br)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	11502243	189482	48	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmc.2019.02.044
	CHEMBL513994	189482	48	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibition of 5-HT2B receptor (unknown origin)Inhibition of 5-HT2B receptor (unknown origin)	ChEMBL	401	4	1	6	4.4	N#Cc1cc(CN2CCC(Nc3ncnc4sc(Cl)cc34)CC2)ccc1F	10.1016/j.bmc.2019.02.044
	146709966	175755	0	None	338	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4583909	175755	0	None	338	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	241	1	1	2	3.4	CC[C@H]1c2ccc3ccccc3c2OC[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	72734865	106288	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3092756	106288	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	CHEMBL3139103	106288	0	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	268	1	3	3	2.0	NC(N)=NC(=O)c1ccc2c(c1)Nc1ccccc1O2	10.1016/j.bmc.2013.10.010
	135509961	136107	2	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	CHEMBL373245	136107	2	None	-3	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	225	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(Cl)c21	10.1021/jm050663x
	10623020	32370	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	CHEMBL14111	32370	0	None	-12	2	Human	8.4	pKi	=	8.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	441	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	18475630	101869	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	330	2	2	3	4.7	Cc1cc2cc(NC(=O)Nc3ccnc4ccccc34)ccc2n1C	10.1016/s0960-894x(01)00343-2
	CHEMBL300835	101869	0	None	19	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	330	2	2	3	4.7	Cc1cc2cc(NC(=O)Nc3ccnc4ccccc34)ccc2n1C	10.1016/s0960-894x(01)00343-2
	10690185	161730	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	365	3	1	3	4.5	CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL41389	161730	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	365	3	1	3	4.5	CC(C)Oc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	1621	2413	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	17	2413	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	5761	2413	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	CHEMBL263881	2413	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	DB04829	2413	17	None	-19	45	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
	2600	3750	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	2608	3750	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	5405	3750	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	CHEMBL17157	3750	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	DB00342	3750	74	None	-1	13	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
	118729264	120673	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402675	120673	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547136	120673	0	None	-3	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	118729248	120677	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402664	120677	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547150	120677	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Br)cc2)C1	10.1016/j.bmc.2015.01.060
	16062788	97445	0	None	-50	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.6	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL270188	97445	0	None	-50	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	333	3	1	3	3.6	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	16062781	155155	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	311	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL402357	155155	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	311	2	1	3	3.6	Fc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	127036932	137323	0	None	1	22	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3752900	137323	0	None	1	22	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	274	7	1	1	4.0	C=CCN(CC=C)CCc1c[nH]c2ccc(Cl)cc12	10.1016/j.bmcl.2015.12.053
	44581973	175577	0	None	-14	10	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL458002	175577	0	None	-14	10	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	73346042	91805	5	None	-3019	17	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	CHEMBL2413153	91805	5	None	-3019	17	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	405	9	0	8	0.9	Cn1c(=O)cnn(CCCCN2CCN(c3ccccc3OCCF)CC2)c1=O	10.1016/j.bmc.2013.05.050
	44451429	155743	3	None	-21	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	226	1	1	3	1.9	O=[N+]([O-])c1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL405829	155743	3	None	-21	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	226	1	1	3	1.9	O=[N+]([O-])c1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	89901929	120678	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402665	120678	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547151	120678	0	None	-38	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	89901938	120687	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402684	120687	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547177	120687	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	145978113	163813	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4206418	163813	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	207	2	1	3	1.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	11312820	136309	1	None	-8	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL373402	136309	1	None	-8	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.2	C[C@H]1CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	46914621	15389	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	CHEMBL1214895	15389	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1cccc(CN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1021/jm100639f
	122187375	122997	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	443	5	0	5	5.6	CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609140	122997	0	None	5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	443	5	0	5	5.6	CCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	4211	57792	83	None	-2	4	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	CHEMBL1670	57792	83	None	-2	4	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	nan
	11737032	84987	0	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223896	84987	0	None	-10	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	222	0	1	2	1.4	O=C1c2c(Cl)cccc2C2CNCCN12	10.1021/jm0612968
	44316017	205429	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80366	205429	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	228	2	1	2	2.2	C[C@H](N)CN1CCc2cc(F)c(Cl)cc21	10.1016/j.bmcl.2003.05.001
	6761	67770	19	None	-7	18	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	CHEMBL1909072	67770	19	None	-7	18	Human	7.5	pKi	=	7.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
	59752584	181471	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4764808	181471	0	None	1	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)c(Cl)c1)CCNCC2	10.1016/j.bmcl.2020.127669
	118717213	120553	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343664	120553	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545802	120553	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	323	4	3	2	2.5	CCCCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	10244831	194864	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	309	3	2	3	4.6	CSc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	CHEMBL54062	194864	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	309	3	2	3	4.6	CSc1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	9888804	194968	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/j.bmcl.2005.08.004
	CHEMBL54719	194968	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/j.bmcl.2005.08.004
	10811153	169095	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	403	3	1	3	5.1	CSc1cc2c(cc1C(F)(F)C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	CHEMBL44015	169095	0	None	-7	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT as radioligand	ChEMBL	403	3	1	3	5.1	CSc1cc2c(cc1C(F)(F)C(F)(F)F)N(C(=O)Nc1cccnc1)CC2	10.1021/jm970741j
	44298173	195470	0	None	-31	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL55331	195470	0	None	-31	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	394	3	1	4	5.1	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cnccc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298236	195939	0	None	-19	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	3	1	4	5.4	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(C)c1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL55964	195939	0	None	-19	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	3	1	4	5.4	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)c(C)c1)CC2	10.1016/s0960-894x(00)00364-4
	10435572	150076	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cccc(F)c4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL395098	150076	0	None	-12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cccc(F)c4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	50878551	90716	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90716	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	9888804	194968	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL54719	194968	4	None	-63	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	428	4	1	4	5.0	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	11121216	30108	0	None	-154	14	Human	6.5	pKi	=	6.5	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL138989	30108	0	None	-154	14	Human	6.5	pKi	=	6.5	Binding	Binding affinities towards 5-hydroxytryptamine 2B receptorBinding affinities towards 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	3845148	65632	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	320	5	0	3	3.8	c1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834251	65632	1	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	320	5	0	3	3.8	c1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	16063181	155409	0	None	-34	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL403764	155409	0	None	-34	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	319	3	1	3	3.5	Fc1ccc(-c2nc(Cc3ccccc3)nc3c2CCNC3)cc1	10.1016/j.bmcl.2008.01.090
	142601337	185946	0	None	-97	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4869695	185946	0	None	-97	5	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	260	2	2	3	2.0	Fc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	145990659	166901	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	273	1	4	6	1.7	NC1=NC2(CCCCC2)NC(Nc2cccc(O)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286819	166901	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	273	1	4	6	1.7	NC1=NC2(CCCCC2)NC(Nc2cccc(O)c2)=N1	10.1021/acsmedchemlett.8b00300
	9906447	195554	2	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL2031738	195554	2	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	CHEMBL555146	195554	2	None	-4365	13	Human	5.5	pKi	=	5.5	Binding	Binding affinity to human recombinant 5HT2B receptorBinding affinity to human recombinant 5HT2B receptor	ChEMBL	351	5	0	3	4.8	C[C@@H]1CCCN1CCc1cc2cc(C(=O)c3ccc(F)cc3)ccc2o1	10.1021/jm201690h
	9909089	186944	0	None	-2511	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
	CHEMBL490417	186944	0	None	-2511	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	402	4	1	5	3.2	Cc1ccc2c(N3CCN(CCc4ccc5c(c4)NC(=O)CO5)CC3)cccc2n1	10.1016/j.bmcl.2008.08.110
	10217207	72083	0	None	-398	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL197807	72083	0	None	-398	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	463	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	10288601	72155	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	465	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198007	72155	0	None	-100	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	465	7	0	5	4.2	COc1ccc(N2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	50898777	56410	0	None	-2951	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	CHEMBL1632158	56410	0	None	-2951	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	441	9	1	6	3.6	COC(=O)CCCCCN1CCC(CNC(=O)c2c3n(c4ccccc24)CCCO3)CC1	10.1016/j.bmc.2010.10.011
	44414105	138160	0	None	-79	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	488	7	0	4	5.9	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL376962	138160	0	None	-79	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	488	7	0	4	5.9	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCC(C)(C)CC1	10.1016/j.bmcl.2006.05.034
	19356259	102002	0	None	-158	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL301784	102002	0	None	-158	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Cl)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	44298192	168126	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	472	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(I)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL433060	168126	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	472	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(I)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	187	3363	18	None	-288	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
	3693566	3363	18	None	-288	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
	CHEMBL88402	3363	18	None	-288	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	10.1016/S0960-894X(96)00503-3
	11766873	206719	0	None	-31	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	558	11	3	8	2.8	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL89967	206719	0	None	-31	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	558	11	3	8	2.8	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C)cc1	10.1016/S0960-894X(96)00503-3
	18931123	207206	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	601	12	4	9	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(NC(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL92809	207206	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	601	12	4	9	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(NC(C)=O)cc1	10.1016/S0960-894X(96)00503-3
	153287567	172360	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	CHEMBL4476396	172360	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	292	1	1	2	4.3	Cc1ccc(N2C[C@@]3(C)NCC[C@H]3c3cc(C)ccc32)cc1	10.1021/acsmedchemlett.9b00225
	153287557	176055	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4591108	176055	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	420	1	1	2	5.2	C[C@@]12CN(c3ccc(Br)cc3)c3ccc(Br)cc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	11463745	151764	0	None	-79	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	400	6	0	4	4.4	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396505	151764	0	None	-79	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	400	6	0	4	4.4	COc1ccc(N2Cc3cccc(Cl)c3C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.10.029
	11750162	151789	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	408	6	0	4	4.6	COc1ccc(N2Cc3cc(C)cc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396527	151789	0	None	-100	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	408	6	0	4	4.6	COc1ccc(N2Cc3cc(C)cc(C)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	179	399	115	None	-17	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	2159	399	115	None	-17	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	963	399	115	None	-17	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	CHEMBL243712	399	115	None	-17	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	DB06288	399	115	None	-17	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	10.1021/jm070516u
	10440	2662	20	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2662	20	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2662	20	None	3	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	155531067	171595	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4465512	171595	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	369	7	3	6	3.3	Nc1nc(NCCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	155558626	174737	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	CHEMBL4561016	174737	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysisDisplacement of [3H]LSD from recombinant human 5HT2B stably expressed in HEK cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting analysis	ChEMBL	355	6	3	6	2.9	Nc1nc(NCCc2ccccc2)nc(-c2cc(Cl)ccc2CO)n1	10.1021/acs.jmedchem.9b00869
	44243470	89069	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
	CHEMBL2334981	89069	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
	CHEMBL2365395	89069	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	431	5	1	6	5.5	CC(C)c1cccc(-c2c(-c3ccc4nn(C)cc4c3)nsc2NC(=O)[C@@H]2C[C@H]2C)n1	10.1016/j.bmcl.2013.01.009
	18931217	206767	0	None	-39	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	623	12	4	10	1.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(S(N)(=O)=O)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90267	206767	0	None	-39	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	623	12	4	10	1.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(S(N)(=O)=O)cc1	10.1016/S0960-894X(96)00503-3
	44439167	90528	0	None	-316	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	CHEMBL238732	90528	0	None	-316	10	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human cloned 5HT2B receptor expressed in HEK293 cells	ChEMBL	483	6	1	5	5.0	Cc1ccc2c(OCCN3CCC(Cc4cc(F)c5c(c4)NC(=O)CO5)CC3)cc(Cl)cc2n1	10.1016/j.bmcl.2006.11.031
	71062790	160029	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ncccc1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	CHEMBL4108274	160029	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ncccc1OC[C@H]1CN(CCN2CCc3ccccc32)CCO1	nan
	44420683	84104	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	CHEMBL220789	84104	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	284	0	1	2	2.6	CC1(C)CN2C(=O)c3c(cccc3C(F)(F)F)[C@@H]2CN1	10.1021/jm0612968
	1355	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	142	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	CHEMBL478	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	DB12110	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2003.05.001
	11151653	91072	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397896	91072	0	None	2	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	Cc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	1355	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	142	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL478	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	DB12110	1998	88	None	-1	16	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL5084249	214882	0	None	-38	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCN(CC)CCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	1704	3496	85	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	4331799	3496	85	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	CHEMBL1334465	3496	85	None	-10	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
	118055337	177347	0	None	-28	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	220	0	1	2	2.0	CC1(C)CN2CCNCc3ccc(F)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4637882	177347	0	None	-28	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	220	0	1	2	2.0	CC1(C)CN2CCNCc3ccc(F)c1c32	10.1016/j.bmcl.2019.126929
	44582675	189677	0	None	-5	15	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL515472	189677	0	None	-5	15	Human	6.5	pKi	=	6.5	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	3336	94972	30	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
	CHEMBL1405922	94972	30	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
	CHEMBL254832	94972	30	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1021/jm100600y
	16573	177595	34	None	-16	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	CHEMBL464099	177595	34	None	-16	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assayDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
	168273532	190161	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	450	3	2	3	7.8	Clc1ccc(Nc2nc3ccccc3c3[nH]c([C@@H]4C[C@@H]5CCC[C@@H](C5)C4)nc23)cc1Cl	10.1021/acs.jmedchem.2c01170
	CHEMBL5174205	190161	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assayDisplacement of [3H]-LSD from human 5HT2B expressed in human HEK293 cell membrane incubated for 90 mins by radioligand binding assay	ChEMBL	450	3	2	3	7.8	Clc1ccc(Nc2nc3ccccc3c3[nH]c([C@@H]4C[C@@H]5CCC[C@@H](C5)C4)nc23)cc1Cl	10.1021/acs.jmedchem.2c01170
	23290944	81797	0	None	-213	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	CHEMBL2164350	81797	0	None	-213	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	392	6	0	4	3.8	O=C(C1CCCCC1)N(CCN1CCN(c2ccccc2)CC1)c1ccccn1	10.1016/j.bmcl.2012.05.119
	6075	150084	42	None	-8	16	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	CHEMBL395110	150084	42	None	-8	16	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	nan
	44247568	82145	55	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	CHEMBL2170062	82145	55	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	337	5	0	5	3.0	Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1	10.1021/jm3007323
	16118923	60116	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
	CHEMBL1642866	60116	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
	CHEMBL1739656	60116	0	None	-30	4	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	434	4	3	5	3.5	O=C(Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1)C1CCNCC1	10.1016/j.bmc.2010.10.033
	11695000	89042	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89042	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89042	0	None	-4	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	122178706	121346	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581251	121346	0	None	1	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	3038495	705	37	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
	7625	705	37	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
	CHEMBL25236	705	37	None	-22	19	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm100600y
	11948707	166143	0	None	-83	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	CHEMBL426317	166143	0	None	-83	13	Human	7.5	pKi	=	7.5	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	373	7	0	8	0.6	COc1cccc(N2CCN(CCCCn3ncc(=O)n(C)c3=O)CC2)c1	10.1016/j.bmcl.2006.01.052
	5624	32663	14	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL1203324	32663	14	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	CHEMBL141343	32663	14	None	5	10	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	520	5	1	8	4.2	Cc1c(C)c2c(c(C)c1O)CCC(C)(CN1CCN(c3cc(N4CCCC4)nc(N4CCCC4)n3)CC1)O2	nan
	56675413	65640	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccccc1CCCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834259	65640	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccccc1CCCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	134143302	145291	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	503	9	5	9	0.6	CC(=O)NCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3913293	145291	0	None	1	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	503	9	5	9	0.6	CC(=O)NCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	90181065	160788	0	None	5	2	Mouse	6.5	pKi	=	6.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@@H](COc2cccc(Cl)c2)C1	nan
	CHEMBL4114519	160788	0	None	5	2	Mouse	6.5	pKi	=	6.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@@H](COc2cccc(Cl)c2)C1	nan
	155566272	175764	0	None	4	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	543	8	3	8	5.1	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CSc2ccccc2F)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL4584140	175764	0	None	4	5	Human	6.5	pKi	=	6.5	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	543	8	3	8	5.1	O[C@H]1[C@H](n2cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc32)[C@H]2C[C@@]2(CSc2ccccc2F)[C@H]1O	10.1021/acs.jmedchem.8b01662
	CHEMBL5089613	215193	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL		None	None	None		C=C[C@H]1CN2CCc3c([nH]c4cccc(O)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	16115654	136949	0	None	-38	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374562	136949	0	None	-38	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	270	0	1	2	2.1	Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	44451373	96306	1	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2ccc3c(c2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	CHEMBL261490	96306	1	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2ccc3c(c2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	50878551	90716	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	CHEMBL2391541	90716	61	None	-1	18	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation counting analysis	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2013.03.066
	118706296	120499	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310119	120499	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545441	120499	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	308	2	3	2	1.3	CC(=O)NC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	134143536	145492	0	None	8	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3914843	145492	0	None	8	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	71459269	82931	0	None	-1479	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	CHEMBL2181166	82931	0	None	-1479	8	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	555	7	0	4	6.3	Fc1cccc2c1nc(OCC1CCN(CCCc3ccc(I)cc3)CC1)c1cccnc12	10.1021/jm300943r
	58911532	91075	0	None	-4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397899	91075	0	None	-4	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	2	1	2	1.6	CCCc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	11176570	91091	1	None	-8	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397915	91091	1	None	-8	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cc(C(F)(F)F)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	56661666	65641	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1cccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834260	65641	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1cccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)c1	10.1016/j.bmcl.2011.08.029
	11150514	84848	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
	CHEMBL223584	84848	0	None	-3	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@H]2CNCCN12	10.1021/jm0612968
	16071847	60115	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
	CHEMBL1642865	60115	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
	CHEMBL1739655	60115	0	None	-229	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	394	5	3	5	2.8	NCCC(=O)Nc1ccc2[nH]nc(S(=O)(=O)c3cccc4ccccc34)c2c1	10.1016/j.bmc.2010.10.033
	11195293	91059	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397883	91059	0	None	1	3	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@]12CNCCN1C(=O)c1ccccc1C2	10.1016/j.bmcl.2013.04.061
	90181070	160513	0	None	1	3	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ccnc(OC[C@H]2CN(CC(=O)N3c4ccccc4CC3C)CCO2)c1	nan
	CHEMBL4112412	160513	0	None	1	3	Mouse	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ccnc(OC[C@H]2CN(CC(=O)N3c4ccccc4CC3C)CCO2)c1	nan
	136118621	76224	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2058420	76224	0	None	5	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	4943	193393	105	None	1	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	CHEMBL526	193393	105	None	1	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	nan
	135399666	168739	7	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL437314	168739	7	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	46884034	7897	0	None	-870	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	347	3	2	2	3.3	O=C(NCc1ccc(-c2ccc(Cl)cc2)cc1F)N1CCNCC1	10.1016/j.bmcl.2010.01.107
	CHEMBL1090397	7897	0	None	-870	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	347	3	2	2	3.3	O=C(NCc1ccc(-c2ccc(Cl)cc2)cc1F)N1CCNCC1	10.1016/j.bmcl.2010.01.107
	118055294	177450	0	None	-24	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	204	1	1	3	1.2	COc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4639115	177450	0	None	-24	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	204	1	1	3	1.2	COc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	56682068	65642	0	None	16	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834261	65642	0	None	16	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	378	8	0	4	4.6	COc1ccc(CCCCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	4189	206899	96	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL1559	206899	96	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	CHEMBL91	206899	96	None	-26	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
	136118651	76295	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058706	76295	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	127052458	140715	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140715	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	9881119	205450	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL80482	205450	0	None	-9	3	Human	6.5	pKi	=	6.5	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	232	2	1	3	1.7	C[C@H](N)CN1CCc2ccc3c(c21)CCCO3	10.1016/j.bmcl.2003.05.001
	117209864	186010	1	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4870675	186010	1	None	-1	6	Human	6.5	pKi	=	6.5	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	258	3	2	4	1.5	COc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	127052458	140715	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818056	140715	0	None	-35	7	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	295	5	1	3	3.4	O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1	10.1016/j.bmc.2016.05.053
	168284710	191569	0	None	-17	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5195241	191569	0	None	-17	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccc(Br)cc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	135398745	2893	112	None	-5	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	47	2893	112	None	-5	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	CHEMBL715	2893	112	None	-5	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	DB00334	2893	112	None	-5	66	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
	127035066	136396	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735434	136396	0	None	7	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	507	14	0	7	5.2	COc1ccc(OC)c(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	156021327	178109	0	None	-33	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	224	0	1	3	1.6	Clc1ccc2c3c1OCCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4648457	178109	0	None	-33	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	224	0	1	3	1.6	Clc1ccc2c3c1OCCN3CCNC2	10.1016/j.bmcl.2019.126929
	132075278	162620	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
	CHEMBL4169752	162620	0	None	-6	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	308	3	0	3	3.1	c1ccc(CN2CCc3cc(N4CCOCC4)ccc3C2)cc1	10.1016/j.ejmech.2018.02.024
	2683	102861	25	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL305906	102861	25	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	CHEMBL334255	102861	25	None	-501	16	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
	3598	187797	76	None	-2	7	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	CHEMBL496	187797	76	None	-2	7	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
	136118635	76283	0	None	5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	CHEMBL2058694	76283	0	None	5	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	321	1	3	2	2.3	O=C1NC(=S)N/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	16115148	84810	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL223469	84810	0	None	-3	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	206	0	1	2	0.9	O=C1c2c(F)cccc2C2CNCCN12	10.1021/jm0612968
	156014235	177154	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	240	0	1	3	2.4	Clc1ccc2c3c1SCCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4634836	177154	0	None	-20	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	240	0	1	3	2.4	Clc1ccc2c3c1SCCN3CCNC2	10.1016/j.bmcl.2019.126929
	53324045	57041	0	None	-9	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL1644980	57041	0	None	-9	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
	11253485	141953	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL387344	141953	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	204	0	2	3	0.5	O=C1c2c(O)cccc2C2CNCCN12	10.1021/jm0612968
	44409101	141225	0	None	-23	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	2	1	4	1.0	COCc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL383051	141225	0	None	-23	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	2	1	4	1.0	COCc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	18735305	204910	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76301	204910	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	320	2	1	2	2.1	C[C@H](N)CN1CCc2cc(F)c(I)cc21	10.1016/j.bmcl.2003.05.001
	44404883	72033	32	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197664	72033	32	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	1	3	2.0	CN(C)CCc1cn(C)c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	44364215	39598	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1ccc2[nH]cc(C3CC3N)c2c1	10.1021/jm980318q
	CHEMBL147434	39598	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1ccc2[nH]cc(C3CC3N)c2c1	10.1021/jm980318q
	118464425	138284	0	None	3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770981	138284	0	None	3	9	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	357	3	2	7	2.8	CCOC(=O)c1cccc(NC2=NC(N(C)C)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	145976085	163641	0	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204576	163641	0	None	2	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	44407453	74374	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	CHEMBL202538	74374	0	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	349	5	1	3	5.0	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1Cl	10.1016/j.bmcl.2005.10.029
	11163458	136543	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	2	1	2	2.8	CCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL373905	136543	0	None	-7	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	2	1	2	2.8	CCCc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	49865831	16129	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	2	1	3	3.0	CCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224033	16129	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	2	1	3	3.0	CCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	132060720	162465	0	None	2	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	CHEMBL4167315	162465	0	None	2	9	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	315	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	11206703	91063	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397887	91063	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@@H]1CNC[C@H]2Cc3ccccc3C(=O)N12	10.1016/j.bmcl.2013.04.061
	10528314	171857	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	469	3	1	3	6.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C(C)(C)C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL446942	171857	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	469	3	1	3	6.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C(C)(C)C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	240	941	43	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	2769	941	43	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	44279790	941	43	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	660	941	43	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL1729	941	43	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	CHEMBL560739	941	43	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	DB00604	941	43	None	-6	25	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human serotonin 5-HT2B receptorBinding affinity to human serotonin 5-HT2B receptor	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1016/j.bmcl.2013.05.018
	18005120	194945	0	None	-100	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	460	4	1	5	5.9	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL54560	194945	0	None	-100	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	460	4	1	5	5.9	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298086	195196	0	None	-39	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(Cl)c(C)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55079	195196	0	None	-39	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	428	3	1	4	5.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(Cl)c(C)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	44298234	196712	0	None	-25	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	462	3	1	4	6.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL56508	196712	0	None	-25	3	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	462	3	1	4	6.2	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)c(Cl)c1)CC2	10.1016/s0960-894x(00)00364-4
	10255548	86734	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232046	86734	0	None	-12	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	467	6	0	5	5.1	COc1ccc(N2Cc3c(c4cc(Cl)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	2726	916	68	None	-19	73	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	621	916	68	None	-19	73	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	83	916	68	None	-19	73	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	CHEMBL71	916	68	None	-19	73	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	DB00477	916	68	None	-19	73	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]DOI from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]DOI from 5HT2B receptor expressed in CHO cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm070516u
	25235287	177692	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	302	0	1	2	4.5	Cc1nccc2c1C(C)(C)Nc1cc(Br)ccc1-2	10.1021/acs.jnatprod.9b01107
	CHEMBL4642292	177692	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	302	0	1	2	4.5	Cc1nccc2c1C(C)(C)Nc1cc(Br)ccc1-2	10.1021/acs.jnatprod.9b01107
	136188797	57292	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	CHEMBL1651094	57292	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	136030744	57291	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	CHEMBL1651093	57291	1	None	-	1	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	11288140	84740	0	None	-12	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL223090	84740	0	None	-12	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	213	0	1	3	0.7	N#Cc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	46830177	8029	30	None	-4365	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1091105	8029	30	None	-4365	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	378	6	2	4	3.6	COc1cc(OC2CCC(C)(C)CC2)c(F)cc1CNC(=O)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	118055319	177502	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	1	1	2	2.6	FC(F)(F)CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4639970	177502	0	None	-20	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	1	1	2	2.6	FC(F)(F)CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	10050022	166332	0	None	-39	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(C2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL427398	166332	0	None	-39	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	462	7	0	4	5.4	COc1ccc(C2CCN(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	49850870	56359	0	None	-3162	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631535	56359	0	None	-3162	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	424	6	1	5	3.3	Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1	10.1021/jm100714c
	49850570	56442	0	None	-2511	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	CHEMBL1632220	56442	0	None	-2511	9	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	417	6	2	4	4.0	CCNC(=O)Nc1cccc(CCN2CCN(c3cccc4nc(C)ccc34)CC2)c1	10.1021/jm100714c
	44298140	100531	0	None	-79	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL291510	100531	0	None	-79	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(C(F)(F)F)cc32)cn1	10.1016/s0960-894x(00)00364-4
	18931172	106147	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1Cl	10.1016/S0960-894X(96)00503-3
	CHEMBL313745	106147	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1Cl	10.1016/S0960-894X(96)00503-3
	18931163	206752	0	None	-50	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	569	11	3	9	2.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C#N)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90175	206752	0	None	-50	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	569	11	3	9	2.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(C#N)cc1	10.1016/S0960-894X(96)00503-3
	18931420	206823	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	628	12	3	9	3.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL90565	206823	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	628	12	3	9	3.4	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(OC(F)(F)F)cc1	10.1016/S0960-894X(96)00503-3
	127052465	140706	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140706	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	10835585	101834	0	None	-63	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(C(F)(F)F)ccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL300618	101834	0	None	-63	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	414	4	1	4	4.7	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(C(F)(F)F)ccc21	10.1016/s0960-894x(00)00365-6
	1836	2574	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	3340	2574	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	5281040	2574	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	CHEMBL787	2574	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	DB00471	2574	59	None	-69	15	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
	10597140	63015	0	None	-251	6	Human	5.4	pKi	=	5.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL1788231	63015	0	None	-251	6	Human	5.4	pKi	=	5.4	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligandBinding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells, using [3H]5-HT as radioligand	ChEMBL	400	5	0	3	4.5	CC1CCN(CC[C@H]2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	1703	3493	97	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
	6604926	3493	97	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
	CHEMBL291536	3493	97	None	-158	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	319	2	2	5	3.7	O=C(Nc1ccnc2c1nccc2)Nc1ccc2c(c1)oc(n2)C	10.1016/s0960-894x(01)00343-2
	44343212	9806	0	None	-100	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	CHEMBL114012	9806	0	None	-100	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.Binding affinity towards 5-hydroxytryptamine 2B receptor (human cloned receptor) in HEK 293 cells using [3H]5-HT as radioligand.	ChEMBL	400	5	0	3	4.5	CC1CCN(CCC2CCCCN2S(=O)(=O)c2cccc3ccccc23)CC1	10.1021/jm991151j
	49865890	16150	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	1	1	3	3.5	Cc1ccccc1NC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224106	16150	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	1	1	3	3.5	Cc1ccccc1NC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	57799324	89063	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337501	89063	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365359	89063	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1ccc2c(c1Cl)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	11312173	182087	0	None	-3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	CHEMBL4782005	182087	0	None	-3	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	285	2	1	3	3.1	Fc1ccc(-c2c3c(nn2C2CCC2)CCNCC3)cc1	10.1016/j.bmcl.2020.127669
	127034715	136369	0	None	35	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	CHEMBL3735261	136369	0	None	35	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	537	15	0	8	5.2	COc1ccc(CCN(CCCc2cc(OC)c(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
	107715	200922	22	None	-14	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL1255837	200922	22	None	-14	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	CHEMBL601773	200922	22	None	-14	20	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
	189	3466	39	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
	5163	3466	39	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
	CHEMBL297784	3466	39	None	-5	17	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	10.1021/jm100600y
	11694810	120513	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310123	120513	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545474	120513	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	11694810	120513	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3310123	120513	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545474	120513	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	281	1	3	2	1.3	CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	10531	1408	21	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	121	1408	21	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	888	1408	21	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	CHEMBL1732	1408	21	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	DB00320	1408	21	None	-15	24	Human	8.4	pKi	=	8.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
	118706301	120512	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3310122	120512	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	CHEMBL3545473	120512	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	265	1	2	1	2.2	CC1c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.05.027
	168293874	192155	0	None	5	11	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5204071	192155	0	None	5	11	Human	8.4	pKi	=	8.4	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	312	2	3	3	3.3	COc1ccc(C2NCCc3c2[nH]c2ccc(F)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	145988313	167211	0	None	104	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292326	167211	0	None	104	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	451	6	2	2	5.0	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	168268877	189946	0	None	1	12	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	CHEMBL5170784	189946	0	None	1	12	Human	8.3	pKi	=	8.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	328	2	3	3	3.8	COc1ccc(C2NCCc3c2[nH]c2ccc(Cl)cc32)c(O)c1	10.1021/acsmedchemlett.1c00694
	127035064	136446	0	None	23	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3735911	136446	0	None	23	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	135	2515	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	1796	2515	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	4184	2515	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	CHEMBL6437	2515	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	DB06148	2515	43	None	-3	58	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
	11681111	120558	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343666	120558	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545815	120558	0	None	-7	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	309	3	2	2	2.4	CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	16062783	154998	0	None	2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	323	3	1	4	3.5	COc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL401509	154998	0	None	2	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	323	3	1	4	3.5	COc1ccc(-c2nc(C3CCCC3)nc3c2CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	14049689	198420	11	None	20	2	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	CHEMBL577294	198420	11	None	20	2	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	1541	28	21	42	-12.4	CC(O)COC[C@H]1O[C@@H]2O[C@@H]3[C@@H](COCC(C)O)O[C@H](O[C@@H]4[C@@H](COCC(C)O)O[C@H](O[C@@H]5[C@@H](COCC(C)O)O[C@H](O[C@@H]6[C@@H](COCC(C)O)O[C@H](O[C@@H]7[C@@H](COCC(C)O)O[C@H](O[C@@H]8[C@@H](COCC(C)O)O[C@H](O[C@H]1[C@H](O)[C@H]2O)[C@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@H](O)[C@H]3O	nan
	58911653	91087	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397911	91087	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	244	1	1	2	1.5	CCc1cc(C)c2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	57799306	89080	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337493	89080	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365469	89080	0	None	1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	222	0	2	2	1.1	O=C1N[C@H]2CNC[C@@H]2c2cccc(Cl)c21	10.1016/j.bmcl.2012.10.091
	9899500	67860	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.11.083
	CHEMBL191054	67860	0	None	-14	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	236	0	1	2	2.4	Cc1c(Cl)ccc2c1N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.11.083
	168281367	190877	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OCC3CC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5185086	190877	0	None	2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	395	6	0	5	4.3	COc1cc2c(cc1OC)-c1c(OC)c(OCC3CC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	118729232	120649	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402655	120649	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547008	120649	0	None	9	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	5.0	CN(C)[C@H]1Cc2ccccc2[C@H](C2CCCCCCC2)C1	10.1016/j.bmc.2015.01.060
	90188146	120672	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402674	120672	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547135	120672	0	None	1	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	16062912	155128	0	None	-56	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	351	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL402164	155128	0	None	-56	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	351	3	1	3	3.7	Fc1ccc(Cc2nc3c(c(-c4ccc(F)cc4)n2)CCNCC3)cc1	10.1016/j.bmcl.2008.01.090
	71461050	82948	0	None	-13	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181189	82948	0	None	-13	5	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	352	5	0	3	5.0	CCCN1CCC(COc2nc3c(F)cccc3c3ccccc23)CC1	10.1021/jm300943r
	45486891	196917	0	None	-83	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL566379	196917	0	None	-83	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	145974750	164731	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4217810	164731	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	127052465	140706	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	CHEMBL3817911	140706	0	None	-10	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	340	5	0	3	3.6	O=C1c2ccccc2C(=O)N1CCCCN1CCC2CCCCC2C1	10.1016/j.bmc.2016.05.053
	89901924	120680	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402667	120680	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547153	120680	0	None	-100	4	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	16062651	95616	0	None	-13	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.1	CC(C)Cc1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL257944	95616	0	None	-13	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	3	1	3	3.1	CC(C)Cc1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	132007291	148921	0	None	-33	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	395	3	2	4	4.3	Fc1ccc(C#Cc2nc(NCc3cccc(Cl)c3)c3nc[nH]c3n2)cc1F	10.1021/acs.jmedchem.6b01183
	CHEMBL3941980	148921	0	None	-33	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	395	3	2	4	4.3	Fc1ccc(C#Cc2nc(NCc3cccc(Cl)c3)c3nc[nH]c3n2)cc1F	10.1021/acs.jmedchem.6b01183
	1782	2501	84	None	-3	23	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	241	2501	84	None	-3	23	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	4168	2501	84	None	-3	23	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	CHEMBL86	2501	84	None	-3	23	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	DB01233	2501	84	None	-3	23	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	nan
	11171955	91064	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397888	91064	0	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.2	C[C@@H]1c2ccccc2C(=O)N2CCNC[C@@H]12	10.1016/j.bmcl.2013.04.061
	16115515	137571	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL375575	137571	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	290	0	1	2	2.5	O=C1c2c(C(F)(F)F)ccc(Cl)c2[C@@H]2CNCCN12	10.1021/jm0612968
	2775690	92982	53	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
	CHEMBL2441619	92982	53	None	-15	6	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5-HT2B receptor (unknown origin)Binding affinity to 5-HT2B receptor (unknown origin)	ChEMBL	295	1	1	3	3.0	Cc1ccc2nc(C(F)(F)F)cc(N3CCNCC3)c2c1	10.1021/ml400312j
	11848624	89117	0	None	2	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
	CHEMBL236587	89117	0	None	2	6	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	10.1016/j.bmcl.2009.09.024
	46230100	199296	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590531	199296	0	None	-2	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	118717211	120552	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3343663	120552	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	CHEMBL3545801	120552	0	None	-33	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	295	2	3	2	1.7	CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21	10.1016/j.bmc.2014.09.005
	44451422	167401	2	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	199	0	1	1	2.2	Fc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL429689	167401	2	None	-9	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	199	0	1	1	2.2	Fc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	75201901	166401	19	None	-301	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	166401	19	None	-301	24	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	118729238	120653	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402659	120653	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547012	120653	0	None	-52	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	118729240	120654	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402660	120654	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547013	120654	0	None	-6	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc([N+](=O)[O-])cc2)C1	10.1016/j.bmc.2015.01.060
	46884098	8155	0	None	-954	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	286	4	2	2	3.1	O=C(NCc1ccc(C2CCCCC2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	CHEMBL1092029	8155	0	None	-954	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to 5HT2B receptorBinding affinity to 5HT2B receptor	ChEMBL	286	4	2	2	3.1	O=C(NCc1ccc(C2CCCCC2)cc1)[C@@H]1CCCN1	10.1016/j.bmcl.2010.01.107
	142601329	186493	5	None	-63	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4877603	186493	5	None	-63	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	122187379	123001	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	441	5	0	5	5.3	C=CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609144	123001	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	441	5	0	5	5.3	C=CCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	122483223	138084	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3764650	138084	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765874	138084	0	None	-5	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	455	8	0	5	5.8	COc1ccccc1N1CCN(CCCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	122187382	123003	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCN1CC(c2ccccc2)c2cc(OC)c(OC)c3c2C1Cc1cc2c(cc1-3)OCO2	10.1016/j.bmcl.2015.07.012
	CHEMBL3609147	123003	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	429	4	0	5	5.2	CCN1CC(c2ccccc2)c2cc(OC)c(OC)c3c2C1Cc1cc2c(cc1-3)OCO2	10.1016/j.bmcl.2015.07.012
	137646281	157782	0	None	-95	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	CHEMBL4083252	157782	0	None	-95	17	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	423	8	0	7	3.8	COc1ccccc1N1CCN(CCCSc2nnc(-c3ccccc3)n2C)CC1	10.1021/acs.jmedchem.9b00412
	122178711	121351	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581256	121351	0	None	1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	509	6	0	5	5.8	COc1cc2c(cc1OCc1ccc(Br)cc1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	46933845	16130	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224034	16130	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	336	1	1	3	3.9	O=C(NC1CCCCC1)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	11957541	1446	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	1229	1446	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	147	1446	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	170617	1446	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	CHEMBL6616	1446	40	None	-2	16	Human	7.4	pKi	=	7.4	Binding	Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.Binding activity against cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand.	ChEMBL	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	10.1021/jm9803525
	25117676	200436	0	None	-831	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL598444	200436	0	None	-831	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	53325242	57040	0	None	-2	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL1644978	57040	0	None	-2	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	21854226	124578	5	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	230	3	2	2	2.5	Oc1cccc2[nH]cc(CCN3CCCC3)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL364061	124578	5	None	-1	3	Human	6.4	pKi	=	6.4	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	230	3	2	2	2.5	Oc1cccc2[nH]cc(CCN3CCCC3)c12	10.1016/j.bmcl.2005.06.104
	2286	3161	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	4927	3161	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	7282	3161	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	CHEMBL643	3161	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	DB01069	3161	51	None	-5	30	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
	59752589	179802	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4745055	179802	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	4.1	CC(C)n1nc2c(c1-c1ccc(Cl)cc1Cl)CCNCC2	10.1016/j.bmcl.2020.127669
	11425677	182311	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4784424	182311	0	None	-2	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	269	1	1	3	3.0	CC(C)(C)n1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	145975946	163896	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	307	8	1	4	3.9	CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	CHEMBL4207355	163896	0	None	-2	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	307	8	1	4	3.9	CCCCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	2406	100376	89	None	-27	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	CHEMBL290106	100376	89	None	-27	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
	3198	205490	76	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL1201049	205490	76	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	CHEMBL808	205490	76	None	-30	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
	118055192	177009	0	None	-46	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	188	0	1	2	1.7	CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4632419	177009	0	None	-46	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	188	0	1	2	1.7	CC1CN2CCNCc3cccc1c32	10.1016/j.bmcl.2019.126929
	10947658	28671	0	None	-39	16	Human	7.4	pKi	=	7.4	Binding	Binding affinities against 5-hydroxytryptamine 2B receptorBinding affinities against 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	CHEMBL137781	28671	0	None	-39	16	Human	7.4	pKi	=	7.4	Binding	Binding affinities against 5-hydroxytryptamine 2B receptorBinding affinities against 5-hydroxytryptamine 2B receptor	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
	44409095	76001	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	1	4	0.8	COc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL205671	76001	0	None	-4	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	219	1	1	4	0.8	COc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	71618702	143357	0	None	1	4	Mouse	6.4	pKi	=	6.4	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1	nan
	CHEMBL3897835	143357	0	None	1	4	Mouse	6.4	pKi	=	6.4	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	400	5	0	4	3.4	CC1Cc2ccccc2N1C(=O)CN1CCO[C@H](COc2cccc(Cl)c2)C1	nan
	156014421	177181	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	3	1.4	[O-][S+]1CCN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4635293	177181	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	256	0	1	3	1.4	[O-][S+]1CCN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	25122654	200505	0	None	-54	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	390	3	2	5	3.0	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc(Cl)c4)c3c2)CC1	10.1021/jm901674f
	CHEMBL598851	200505	0	None	-54	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	390	3	2	5	3.0	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc(Cl)c4)c3c2)CC1	10.1021/jm901674f
	135476741	155501	11	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.8	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL404232	155501	11	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.8	CN1C(=N)N(C)/C(=C/c2c[nH]c3ccccc23)C1=O	10.1016/j.bmc.2013.09.011
	117209962	184845	1	None	-16	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4852622	184845	1	None	-16	7	Human	6.4	pKi	=	6.4	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	242	2	2	3	1.8	Cc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	136118716	93030	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442271	93030	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	180	400	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	200	400	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	2160	400	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	CHEMBL629	400	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	DB00321	400	56	None	-35	40	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
	122178703	121343	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581248	121343	0	None	-1	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	383	5	0	5	4.3	COc1cc2c(cc1OC(C)C)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	127049980	140609	1	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccc(Br)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814485	140609	1	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	525	12	0	5	5.9	COc1ccc(CCN(CCCc2ccc(Br)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	134144970	150749	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	461	8	3	9	2.3	CCCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3956531	150749	0	None	4	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	461	8	3	9	2.3	CCCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	12901777	137973	32	None	-7	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL376455	137973	32	None	-7	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	188	0	1	2	0.8	O=C1c2ccccc2C2CNCCN12	10.1021/jm0612968
	44407337	74175	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202324	74175	0	None	-5	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	265	5	1	3	3.4	C=CCN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	45378934	201623	0	None	-8	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	CHEMBL605971	201623	0	None	-8	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	406	3	1	6	3.1	Cn1nc2ccc(N3CC[C@@H](N)C3)cc2c1S(=O)(=O)c1cccc2ccccc12	10.1021/jm901674f
	135449090	189290	4	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	268	1	1	2	1.9	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL512332	189290	4	None	-2	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	268	1	1	2	1.9	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	4595	176691	106	None	2	15	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL46	176691	106	None	2	15	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	nan
	136118729	93033	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442274	93033	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	10150497	4043	47	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	3240	4043	47	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	CHEMBL392760	4043	47	None	-223	4	Human	6.3	pKi	=	6.3	Binding	Inhibition of human 5HT2B receptor expressed in CHO cellsInhibition of human 5HT2B receptor expressed in CHO cells	ChEMBL	380	4	1	7	2.7	NCCc1cn(c2c1cccc2)S(=O)(=O)c1c(Cl)nc2n1ccs2	10.1021/jm070521y
	168	3951	15	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	6604042	3951	15	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	CHEMBL309760	3951	15	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	10.1016/j.bmcl.2003.05.001
	10430183	205605	0	None	-457	7	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
	CHEMBL81728	205605	0	None	-457	7	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human 5-HT2B receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	385	5	1	5	2.1	O=C(NCCN1CCN(c2cccc3c2OCCO3)CC1)c1ccc(F)cc1	10.1021/acs.jmedchem.2c00633
	118055338	177161	0	None	-57	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.4	CC1CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	CHEMBL4634942	177161	0	None	-57	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	222	0	1	2	2.4	CC1CN2CCNCc3ccc(Cl)c1c32	10.1016/j.bmcl.2019.126929
	56852956	112016	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	112016	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	71618636	148861	0	None	-7	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	CHEMBL3941579	148861	0	None	-7	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	56665075	65635	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834254	65635	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	350	6	0	4	3.8	COc1ccc(CCN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmcl.2011.08.029
	1547484	937	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	654	937	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	9072	937	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	CHEMBL43064	937	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	DB00568	937	74	None	-8	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	nan
	44582678	181550	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL476839	181550	0	None	-3	10	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	136188797	57292	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	CHEMBL1651094	57292	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@H]1SC[C@](C)(C(=O)O)N1C	10.1021/np100588c
	102	4096	48	None	-93	50	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	3659	4096	48	None	-93	50	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	8969	4096	48	None	-93	50	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	CHEMBL15245	4096	48	None	-93	50	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	DB01392	4096	48	None	-93	50	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	nan
	24826787	91068	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397892	91068	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2c(cccc2C(F)(F)F)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	24826869	91073	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397897	91073	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1ccc2c(c1)C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	145964159	164305	0	None	3	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212435	164305	0	None	3	6	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	3	2	4	2.6	C[C@@H]1SC(c2ccccc2O)=N[C@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	168281307	190782	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5183799	190782	0	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	56852956	112016	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	CHEMBL3289656	112016	1	None	-12	9	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayDisplacement of [3H]LSD from human 5-HT2B receptor by PDSP assay	ChEMBL	339	5	0	6	2.8	c1cnc(N2CCN(CCCc3nc4ccccc4s3)CC2)nc1	10.1016/j.bmc.2014.04.026
	11347858	137012	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	2	3	1.3	O=C1c2c(cc(CO)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL374659	137012	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	286	1	2	3	1.3	O=C1c2c(cc(CO)cc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	136030744	57291	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	CHEMBL1651093	57291	1	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	352	3	2	6	2.5	C[C@@H]1SC(c2ccccc2O)=N[C@H]1[C@@H]1SC[C@](C)(C(=O)O)N1C	10.1021/acs.jnatprod.7b00317
	134149008	148437	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	353	3	3	8	-0.1	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)O)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL3938006	148437	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	353	3	3	8	-0.1	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)O)C[C@H]12	10.1021/acs.jmedchem.6b01183
	16115521	84636	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL222466	84636	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc2c(cc1Cl)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	155566338	175887	0	None	-446	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	405	4	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4587144	175887	0	None	-446	6	Human	6.3	pKi	=	6.3	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	405	4	4	8	1.4	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	134134668	144228	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	6	4	8	1.4	CCC(CC)Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL3904817	144228	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	6	4	8	1.4	CCC(CC)Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	2477	742	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	36	742	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	437	742	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	CHEMBL49	742	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	DB00490	742	59	None	-13	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	nan
	11666237	89083	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337496	89083	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365472	89083	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	236	0	2	2	1.4	Cc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	11609026	89098	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337500	89098	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365705	89098	0	None	-3	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.8	O=C1N[C@H]2CNC[C@@H]2c2ccc(Cl)c(Cl)c21	10.1016/j.bmcl.2012.10.091
	44409031	74927	0	None	-30	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203230	74927	0	None	-30	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	223	0	1	3	1.5	C[C@@H]1CNC[C@H]2Cc3ccc(Cl)nc3N12	10.1016/j.bmcl.2005.11.083
	122178702	121342	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581247	121342	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OCCF)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	168295984	192196	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5204813	192196	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	431	6	0	5	5.0	COc1cc2c(cc1OC)-c1c(OC)c(OCc3ccccc3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	134155462	151085	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	339	3	3	8	-0.2	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL3959210	151085	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	339	3	3	8	-0.2	CN(C)c1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	10058473	20623	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2sccc12	10.1021/jm980692q
	CHEMBL13086	20623	0	None	-4	4	Human	6.3	pKi	=	6.3	Binding	Compound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptorCompound was tested for the displacement of [3H]5-HT from clone human 5-hydroxytryptamine 2B receptor	ChEMBL	194	3	1	2	2.3	CN(C)CCc1c[nH]c2sccc12	10.1021/jm980692q
	71681898	91060	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
	CHEMBL2397884	91060	0	None	1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	0	2	1.0	CN1CCN2C(=O)c3ccccc3C[C@@H]2C1	10.1016/j.bmcl.2013.04.061
	49865832	16131	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	3	1	3	3.3	CCCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224035	16131	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	310	3	1	3	3.3	CCCCNC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	136118618	76221	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058417	76221	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cc(Br)ccc23)N1C	10.1016/j.bmc.2013.09.011
	56707820	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	9155	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	CHEMBL4548689	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	CHEMBL5306285	194560	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	486	7	2	9	3.2	C[C@H](NC(=O)c1cn(C2(C#N)CC2)cn1)C(=O)Nc1nc(-c2cccc(-c3ccn(C)n3)c2)cs1	10.6019/CHEMBL5303766
	9859257	205100	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	CHEMBL77880	205100	0	None	-5	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	218	2	1	3	1.3	C[C@H](N)CN1CCc2ccc3c(c21)CCO3	10.1016/j.bmcl.2003.05.001
	2105	3032	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	47811	3032	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	48	3032	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	CHEMBL531	3032	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	DB01186	3032	37	None	-28	33	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
	71028	84332	25	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	216	1	2	2	2.4	COc1ccc2[nH]c3c(c2c1)CCNC3C	10.1021/jm100600y
	CHEMBL221811	84332	25	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	216	1	2	2	2.4	COc1ccc2[nH]c3c(c2c1)CCNC3C	10.1021/jm100600y
	25122652	200639	0	None	-134	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	3	2	5	3.8	Cc1ccc(S(=O)(=O)c2n[nH]c3ccc(N4CCC(N)CC4)cc23)c2ccccc12	10.1021/jm901674f
	CHEMBL599663	200639	0	None	-134	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	3	2	5	3.8	Cc1ccc(S(=O)(=O)c2n[nH]c3ccc(N4CCC(N)CC4)cc23)c2ccccc12	10.1021/jm901674f
	11653679	181167	1	None	-75	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned 5HT2B receptorBinding affinity to human cloned 5HT2B receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
	CHEMBL476108	181167	1	None	-75	11	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human cloned 5HT2B receptorBinding affinity to human cloned 5HT2B receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
	56707820	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	9155	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	CHEMBL4548689	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL4507323
	56707820	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5212743
	9155	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5212743
	CHEMBL4548689	2890	39	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000354a HTR2B	ChEMBL	307	5	3	6	2.2	OCc1ccccc1c1nc(NCc2ccccc2)nc(n1)N	10.6019/CHEMBL5212743
	5009938	15377	1	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	306	4	0	3	3.8	c1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214829	15377	1	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	306	4	0	3	3.8	c1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	11393128	182837	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4791646	182837	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	323	2	1	3	3.8	CC(C)n1nc2c(c1-c1ccc(C(F)(F)F)cc1)CCNCC2	10.1016/j.bmcl.2020.127669
	10527432	36256	0	None	1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1Cl)CC2	10.1021/jm990388c
	CHEMBL14458	36256	0	None	1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	447	3	1	3	6.0	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1Cl)CC2	10.1021/jm990388c
	10550405	38027	0	None	-5	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14606	38027	0	None	-5	3	Human	8.3	pKi	=	8.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	427	3	1	3	5.7	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	75306277	109227	0	None	-2	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	CHEMBL3217984	109227	0	None	-2	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
	166	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	3045227	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	CHEMBL76781	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2003.05.001
	166	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	3045227	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	CHEMBL76781	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	10.1016/j.bmcl.2005.10.029
	11536843	115097	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343673	115097	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	11500509	120555	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343670	120555	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545812	120555	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	307	1	2	2	2.1	NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	31101	726	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	35	726	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	403	726	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	CHEMBL493	726	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	DB01200	726	40	None	-26	36	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
	10331436	323	10	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
	160	323	10	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
	CHEMBL133455	323	10	None	-2	6	Human	8.3	pKi	=	8.3	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	10.1021/jm030205t
	242	469	124	None	-1	52	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	34	469	124	None	-1	52	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	60795	469	124	None	-1	52	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	CHEMBL1112	469	124	None	-1	52	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	DB01238	469	124	None	-1	52	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor incubated for 1 hr by liquid scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.ejmech.2021.113931
	44364163	39758	1	None	-3	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	190	1	2	1	2.1	NC1CC1c1c[nH]c2ccc(F)cc12	10.1021/jm980318q
	CHEMBL147656	39758	1	None	-3	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	190	1	2	1	2.1	NC1CC1c1c[nH]c2ccc(F)cc12	10.1021/jm980318q
	118464420	138220	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL3770342	138220	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acsmedchemlett.8b00300
	127035063	136461	0	None	21	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	CHEMBL3736149	136461	0	None	21	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccccc1CCCN(CCc1ccc(OC)c(OC)c1)CCc1ccc2c(c1)OCO2	10.1039/C4MD00418C
	44404886	72196	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL198124	72196	0	None	1	4	Human	8.2	pKi	=	8.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	260	6	1	3	3.3	CCCCn1cc(CCN(C)C)c2c(O)cccc21	10.1016/j.bmcl.2005.06.104
	CHEMBL5077293	214468	0	None	-17	9	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		COc1ccccc1-c1cc(C2CCNC2)ccc1Cl	10.1021/acs.jmedchem.1c00110
	136118648	76292	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058703	76292	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	118729266	120674	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402676	120674	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547137	120674	0	None	1	4	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2cccc(Cl)c2)C1	10.1016/j.bmc.2015.01.060
	10837002	35336	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1021/jm990388c
	CHEMBL14374	35336	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1021/jm990388c
	18475647	197689	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	334	5	2	3	4.7	CCN(CC)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	CHEMBL57135	197689	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	334	5	2	3	4.7	CCN(CC)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	10837002	35336	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL14374	35336	0	None	-79	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	444	4	1	5	5.2	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298175	100913	0	None	-39	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL294030	100913	0	None	-39	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3Cl)nc1)CC2	10.1016/s0960-894x(00)00364-4
	11742218	195770	0	None	-25	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	4	1	4	5.4	CCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55792	195770	0	None	-25	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	408	4	1	4	5.4	CCc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	18931202	206780	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1ccc(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL90346	206780	0	None	-12	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	393	7	2	5	2.4	COc1ccc(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	73350823	102503	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
	CHEMBL2424668	102503	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
	CHEMBL3040578	102503	0	None	-33	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by competitive binding assayBinding affinity to human 5HT2B receptor by competitive binding assay	ChEMBL	509	8	1	5	3.7	O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1	10.1016/j.bmcl.2013.07.045
	10257042	204338	0	None	-12	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	551	6	3	3	7.3	O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1	10.1016/s0960-894x(01)00397-3
	CHEMBL71707	204338	0	None	-12	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity for 5-hydroxytryptamine 2B receptor was determinedBinding affinity for 5-hydroxytryptamine 2B receptor was determined	ChEMBL	551	6	3	3	7.3	O=C(/C=C/c1ccc(Cl)c(Cl)c1)N[C@H]1CC[C@@H](CN2[C@H]3CC[C@@H]2C[C@@H](c2c[nH]c4ccc(O)cc24)C3)CC1	10.1016/s0960-894x(01)00397-3
	9866423	72275	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	413	7	0	4	4.1	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198330	72275	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	413	7	0	4	4.1	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	24887527	79997	0	None	-100	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	4.9	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	CHEMBL212886	79997	0	None	-100	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	4.9	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.05.034
	24887290	80220	0	None	-630	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL213839	80220	0	None	-630	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(N2CC=C(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	44414051	166203	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	5.0	COc1ccc(C2=C(C)CN(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL426684	166203	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	440	7	0	4	5.0	COc1ccc(C2=C(C)CN(c3ccc(Cl)cc3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	10454231	168937	0	None	-79	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(C2=CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL438963	168937	0	None	-79	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	410	7	0	4	4.1	COc1ccc(C2=CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	11292933	56364	45	None	-2511	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631540	56364	45	None	-2511	9	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	415	5	1	4	3.4	Cc1ccc2c(N3CCN(CCc4cccc(N5CCNC5=O)c4)CC3)cccc2n1	10.1021/jm100714c
	44298100	196042	0	None	-158	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2ccc(Cl)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL56050	196042	0	None	-158	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.5	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2ccc(Cl)c3Cl)cn1	10.1016/s0960-894x(00)00364-4
	153287551	169928	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	307	1	0	2	3.8	CC(=O)N1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	CHEMBL4441621	169928	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	307	1	0	2	3.8	CC(=O)N1CC[C@H]2c3cccc(-c4ccccc4)c3OC[C@]21C	10.1021/acsmedchemlett.9b00225
	153287553	171080	0	None	-79	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	CHEMBL4457754	171080	0	None	-79	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	264	1	1	2	3.7	C[C@@]12CN(c3ccccc3)c3ccccc3[C@@H]1CCN2	10.1021/acsmedchemlett.9b00225
	17989823	152052	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.0	COc1ccc(N2Cc3cccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL396748	152052	0	None	-316	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	448	6	0	4	5.0	COc1ccc(N2Cc3cccc(C(F)(F)F)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10813396	98688	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cc(F)cc(F)c3)c1)CC2	10.1021/jm990388c
	CHEMBL277732	98688	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	449	3	1	3	5.6	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cc(F)cc(F)c3)c1)CC2	10.1021/jm990388c
	18357723	195497	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	424	4	1	4	4.4	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Br)ccc21	10.1016/s0960-894x(00)00365-6
	CHEMBL55388	195497	0	None	-31	3	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	424	4	1	4	4.4	O=C(Nc1ccc(OCc2ccccn2)nc1)N1CCc2cc(Br)ccc21	10.1016/s0960-894x(00)00365-6
	44298129	195934	0	None	-125	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	364	3	1	4	4.3	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55958	195934	0	None	-125	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	364	3	1	4	4.3	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	2028	2958	80	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	359	2958	80	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	4634	2958	80	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	CHEMBL1231	2958	80	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	DB01062	2958	80	None	-40	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	nan
	136020617	57293	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/np100588c
	CHEMBL1651095	57293	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptor by radioligand displacement assayBinding affinity to human 5HT2B receptor by radioligand displacement assay	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/np100588c
	132060770	162615	0	None	-8	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
	CHEMBL4169689	162615	0	None	-8	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	451	7	0	6	3.5	CCOC(=O)CCN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)CC3)CC1	10.1016/j.ejmech.2018.02.024
	135367820	164797	0	None	-9	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4218672	164797	0	None	-9	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	232	1	1	3	2.2	Fc1ccc(-c2noc3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	135846981	93023	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1/N/C(=C/c2c[nH]c3ccccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442265	93023	0	None	1	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1/N/C(=C/c2c[nH]c3ccccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL5306285	194560	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL	486	7	2	9	3.2	C[C@H](NC(=O)c1cn(C2(C#N)CC2)cn1)C(=O)Nc1nc(-c2cccc(-c3ccn(C)n3)c2)cs1	10.6019/CHEMBL5303766
	CHEMBL5072247	214252	5	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL		None	None	None		CC[C@H]1CN2CCc3c([nH]c4cccc(O)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	145980271	166468	0	None	1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4278465	166468	0	None	1	16	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
	CHEMBL4475494	213928	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O	10.6019/CHEMBL4879554
	71452172	83489	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysis	ChEMBL	274	6	1	5	2.4	c1ccc(OCc2cc(OC[C@@H]3CCCN3)no2)cc1	10.1021/ml3002715
	CHEMBL2203551	83489	0	None	-1	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by microbeta scintillation counting analysis	ChEMBL	274	6	1	5	2.4	c1ccc(OCc2cc(OC[C@@H]3CCCN3)no2)cc1	10.1021/ml3002715
	46230100	199296	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	CHEMBL590531	199296	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	231	0	2	3	0.9	Cc1ccc2c(c1)N1CCNCCC1NC2=O	10.1016/j.bmcl.2009.12.014
	127049981	140574	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(I)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3813789	140574	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	573	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(I)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	135464118	93031	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2442272	93031	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	304	1	4	2	1.9	N=C1NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	155556596	174399	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT2B by radio-ligand binding displacement assayInhibition of human 5HT2B by radio-ligand binding displacement assay	ChEMBL	428	5	4	7	3.1	OC[C@@]12C[C@@H]1[C@@H](n1cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b00689
	CHEMBL4552895	174399	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of human 5HT2B by radio-ligand binding displacement assayInhibition of human 5HT2B by radio-ligand binding displacement assay	ChEMBL	428	5	4	7	3.1	OC[C@@]12C[C@@H]1[C@@H](n1cc(-c3ccccc3)c3c(Nc4ccccc4)ncnc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b00689
	161	751	6	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	4284720	751	6	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	CHEMBL1255834	751	6	None	2	6	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	nan
	58911644	91071	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	CHEMBL2397895	91071	0	None	3	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1cccc2c1C(=O)N1CCNC[C@H]1C2	10.1016/j.bmcl.2013.04.061
	136020617	57293	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL1651095	57293	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cellsDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in baculovirus infected Sf9 cells	ChEMBL	223	2	2	4	1.6	C[C@@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4475494	213928	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cnn4cccnc34)c(N3CCOCC3)cc2C1=O	10.6019/CHEMBL4879554
	44407460	140325	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	CHEMBL380763	140325	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	315	5	1	3	4.4	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCc1ccccc1	10.1016/j.bmcl.2005.10.029
	90181061	160847	0	None	1	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	CHEMBL4115017	160847	0	None	1	2	Mouse	5.3	pKi	=	5.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	381	5	0	5	2.4	Cc1ncccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	145	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	1832	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	CHEMBL7257	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	DB14010	140	49	None	-87	30	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/jm050663x
	2726	916	68	None	-19	73	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	621	916	68	None	-19	73	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	83	916	68	None	-19	73	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	CHEMBL71	916	68	None	-19	73	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	DB00477	916	68	None	-19	73	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm100600y
	72735042	106283	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3092763	106283	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	CHEMBL3139089	106283	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	293	2	3	2	1.6	NC(N)=NC(=O)/C=C/c1ccc2c(c1)C(O)c1ccccc1-2	10.1016/j.bmc.2013.10.010
	127036953	137490	0	None	-5	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3754166	137490	0	None	-5	22	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	318	7	1	1	4.1	C=CCN(CC=C)CCc1c[nH]c2ccc(Br)cc12	10.1016/j.bmcl.2015.12.053
	118709751	113514	0	None	-407	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	CHEMBL3321792	113514	0	None	-407	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
	136118653	93025	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442267	93025	0	None	2	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3ccc(Br)cc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	54764240	68839	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922539	68839	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	242	1	1	2	2.7	CC/C=C1\C[C@H]2CNc3ccccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL4592872	213997	0	None	-4	3	Human	5.3	pKi	=	5.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000340a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000340a HTR2B	ChEMBL		None	None	None		O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N1CCc2ncccc2[C@H]1c1ccc(F)cc1	10.6019/CHEMBL5212743
	58405078	110669	0	None	-6	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	CHEMBL3260335	110669	0	None	-6	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	310	5	1	5	3.0	Cc1nc(COc2ccc(Cl)cc2OC2CNC2)cs1	10.1021/ml500082j
	398712	77840	5	None	-52	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	CHEMBL209324	77840	5	None	-52	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor by radioligand binding assayBinding affinity to 5HT2B receptor by radioligand binding assay	ChEMBL	417	9	1	5	2.9	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1	10.1021/jm0508641
	9859144	67331	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	208	0	1	2	1.7	Clc1ccc2c(c1)N1CCNCC1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL188605	67331	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	208	0	1	2	1.7	Clc1ccc2c(c1)N1CCNCC1C2	10.1016/j.bmcl.2005.05.074
	122178701	121341	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581246	121341	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	9	0	5	5.4	CCCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	122178708	121348	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	CHEMBL3581253	121348	0	None	-1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC1CCCCC1)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/acs.jnatprod.2c00365
	2884131	166884	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4286420	166884	7	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	275	1	3	5	2.2	NC1=NC2(CCCCC2)NC(Nc2cccc(F)c2)=N1	10.1021/acsmedchemlett.8b00300
	71655748	87796	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	359	5	1	4	4.8	CC(C)CCOc1ccc2c(c1)[C@H]1OCCC[C@H]1[C@@H](C1CCOCC1)N2	10.1021/jm400181k
	CHEMBL2338343	87796	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	359	5	1	4	4.8	CC(C)CCOc1ccc2c(c1)[C@H]1OCCC[C@H]1[C@@H](C1CCOCC1)N2	10.1021/jm400181k
	142601335	186397	0	None	-44	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4876193	186397	0	None	-44	7	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	256	2	2	3	2.2	Cc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	134157367	153874	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	517	10	5	9	1.0	CC(=O)NCCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3983143	153874	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	517	10	5	9	1.0	CC(=O)NCCCNC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	11644842	89068	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337105	89068	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365394	89068	0	None	-6	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	244	1	2	2	1.9	Cc1cc(C(C)C)cc2c1C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	4098	32475	30	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1255739	32475	30	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL1411979	32475	30	None	-14	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	nan
	CHEMBL4557026	213984	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000700a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000700a HTR2B	ChEMBL		None	None	None		C[C@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccn1	10.6019/CHEMBL5212743
	54764241	68838	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922538	68838	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	258	1	1	3	2.3	C/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	18735313	204911	1	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL76307	204911	1	None	-4	3	Human	7.3	pKi	=	7.3	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	210	2	1	2	2.1	C[C@H](N)CN1CCc2ccc(Cl)cc21	10.1016/j.bmcl.2003.05.001
	24826868	91053	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397877	91053	1	None	-1	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2cc(Cl)ccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	127049979	140625	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(Cl)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	CHEMBL3814708	140625	1	None	4	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor measured after 90 mins by microbeta scintillation counting method	ChEMBL	481	12	0	5	5.8	COc1ccc(CCN(CCCc2ccc(Cl)cc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1016/j.bmcl.2016.05.079
	5282379	194961	69	None	1	3	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	CHEMBL547	194961	69	None	1	3	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	nan
	118729242	120659	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402661	120659	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547028	120659	0	None	-1	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccc(C(F)(F)F)cc2)C1	10.1016/j.bmc.2015.01.060
	181743	178548	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL467094	178548	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2015.07.012
	181743	178548	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	CHEMBL467094	178548	5	None	-275	22	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
	16115511	84808	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223466	84808	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	250	1	1	2	2.0	CCc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	122178709	121349	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581254	121349	0	None	-2	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	381	6	0	5	4.0	C=CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	4407909	192842	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5182943	192842	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	CHEMBL5221893	192842	1	None	4	10	Human	7.3	pKi	=	7.3	Binding	Binding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	356	4	2	4	3.6	COc1cc(OC)c(C2NCCc3c2[nH]c2ccc(F)cc32)cc1OC	10.1021/acsmedchemlett.1c00694
	118055233	177244	0	None	-38	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	214	0	1	2	2.0	c1cc2c3c(c1)C1(CCC1)CN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4636196	177244	0	None	-38	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	214	0	1	2	2.0	c1cc2c3c(c1)C1(CCC1)CN3CCNC2	10.1016/j.bmcl.2019.126929
	11448649	83404	0	None	-27	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	CHEMBL219734	83404	0	None	-27	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	272	1	1	3	1.7	O=C1c2c(OC(F)(F)F)cccc2C2CNCCN12	10.1021/jm0612968
	29101	72195	2	None	-10	2	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	298	5	2	4	1.8	CN(C)CCc1cn(C)c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL198123	72195	2	None	-10	2	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	298	5	2	4	1.8	CN(C)CCc1cn(C)c2cccc(OP(=O)(O)O)c12	10.1016/j.bmcl.2005.06.104
	71061709	149503	0	None	-3	12	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3946540	149503	0	None	-3	12	Mouse	6.3	pKi	=	6.3	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	11222829	91082	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397906	91082	0	None	-3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2cccc(C(F)(F)F)c2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	162669941	182631	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	4	8	1.8	CC(C)C(Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C(C)C	10.1016/j.bmcl.2020.127599
	CHEMBL4788883	182631	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	4	8	1.8	CC(C)C(Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C(C)C	10.1016/j.bmcl.2020.127599
	44404895	170785	0	None	-12	3	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	292	3	2	2	3.9	Oc1cccc2[nH]cc(CCN3CCCc4ccccc43)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL445331	170785	0	None	-12	3	Human	5.3	pKi	=	5.3	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	292	3	2	2	3.9	Oc1cccc2[nH]cc(CCN3CCCc4ccccc43)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL4798829	214030	7	None	6	2	Human	6.3	pKi	=	6.3	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000752a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000752a HTR2B	ChEMBL		None	None	None		c1ccc2oc(-c3csc(C4CCN(Cc5nc6ncccc6[nH]5)CC4)n3)cc2c1	10.6019/CHEMBL5212743
	44582705	186972	0	None	-3	13	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL490632	186972	0	None	-3	13	Human	6.3	pKi	=	6.3	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
	3158	56237	27	None	-389	20	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	CHEMBL1628227	56237	27	None	-389	20	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
	122178699	121340	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581245	121340	0	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	7	0	5	4.6	CCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	216239	23763	118	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1200485	23763	118	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	CHEMBL1336	23763	118	None	2	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	ChEMBL	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	10.1021/jm300338m
	73213195	104432	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	104432	0	None	-1	12	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	11808247	18043	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL126667	18043	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819366	18043	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	11808247	18043	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL126667	18043	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819366	18043	0	None	-6	9	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	285	5	0	2	3.7	Fc1ccc(OCCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	44456400	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	44456400	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL1188501	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL2436555	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	CHEMBL536539	12802	0	None	-2	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells after 90 mins by scintillation counting analysis	ChEMBL	181	0	2	3	1.4	NC1=Nc2ccc(Cl)cc2CN1	10.1016/j.bmcl.2013.08.072
	49865830	16128	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.0	CC(C)NC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224032	16128	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	296	1	1	3	3.0	CC(C)NC(=O)N1OCC2CSc3ccc(F)cc3C21	10.1016/j.bmcl.2010.07.074
	41305446	167228	1	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	398	5	1	2	4.5	O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	CHEMBL4292719	167228	1	None	1	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	398	5	1	2	4.5	O=C(NCc1ccccc1)C1CCN(C(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1039/C8MD00204E
	46914772	15409	0	None	56	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1215036	15409	0	None	56	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	368	7	0	4	4.1	FCCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	73213195	104432	0	None	-1	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104092	104432	0	None	-1	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.6	CN1CCc2c(c3cccc4c3n2Cc2ccccc2C4)C1	10.1016/j.bmcl.2013.12.024
	122178700	121279	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3580670	121279	0	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	411	8	0	5	5.0	CCCCCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	71681899	91058	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397882	91058	0	None	-3	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	202	0	1	2	0.7	O=C1c2ccccc2C[C@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	2291	3162	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	2561	3162	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	4932	3162	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	CHEMBL631	3162	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	DB01182	3162	58	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	nan
	44364514	121673	10	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	NC1CC1c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL358810	121673	10	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	NC1CC1c1c[nH]c2ccccc12	10.1021/jm980318q
	10103618	121500	4	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@@H]1C[C@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL358522	121500	4	None	-1	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@@H]1C[C@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	50878551	90716	61	None	-1	18	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL2391541	90716	61	None	-1	18	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	270	8	1	2	3.4	C=CCN(CC=C)CCc1c[nH]c2ccc(OC)cc12	10.1016/j.bmcl.2015.12.053
	11492300	89082	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337495	89082	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365471	89082	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	188	0	2	2	0.5	O=C1N[C@H]2CNC[C@@H]2c2ccccc21	10.1016/j.bmcl.2012.10.091
	68691189	91079	0	None	1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397903	91079	0	None	1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	227	0	1	3	0.5	N#Cc1ccc2c(c1)C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	25117677	200229	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL597009	200229	0	None	-23	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	420	4	1	5	3.7	CN(C)[C@H]1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	176	397	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2157	397	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	2566	397	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	CHEMBL633	397	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	DB01118	397	66	None	-1	31	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
	127051844	140822	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140822	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	127051844	140822	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3819427	140822	0	None	-48	9	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	322	6	1	3	2.8	NC(=O)c1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	136118620	76223	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2058419	76223	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.6	CN1C(=N)N(C)/C(=C/c2c[nH]c3cccc(Br)c23)C1=O	10.1016/j.bmc.2013.09.011
	44397846	67615	0	None	-22	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL190584	67615	0	None	-22	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	202	0	1	2	1.7	Cc1cccc2c1N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	127034729	136340	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	463	12	0	6	5.1	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	CHEMBL3734894	136340	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	463	12	0	6	5.1	COc1cccc(CCCN(CCc2ccc(OC)c(OC)c2)Cc2ccc3c(c2)OCO3)c1	10.1039/C4MD00418C
	127036910	136440	0	None	18	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	419	10	0	5	4.7	COc1ccc(CCN(CCc2ccc3c(c2)OCO3)Cc2ccccc2)cc1OC	10.1039/C4MD00418C
	CHEMBL3735862	136440	0	None	18	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	419	10	0	5	4.7	COc1ccc(CCN(CCc2ccc3c(c2)OCO3)Cc2ccccc2)cc1OC	10.1039/C4MD00418C
	136118615	93036	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442277	93036	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3c(Br)cccc23)C1=O	10.1016/j.bmc.2013.09.011
	657255	199061	34	None	-9	15	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	CHEMBL588119	199061	34	None	-9	15	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
	45486824	197354	0	None	-14	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL569251	197354	0	None	-14	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	421	4	3	4	3.3	O=C1Cc2c(ccc3c2OC[C@H](CNCC2CCc4[nH]c5ccc(F)cc5c4C2)O3)N1	10.1016/j.bmcl.2009.08.050
	135427931	73091	2	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	317	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(I)c21	10.1021/jm050663x
	CHEMBL201132	73091	2	None	-1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	317	2	2	4	1.7	C[C@H](N)Cn1ncc2ccc(O)c(I)c21	10.1021/jm050663x
	58911579	91067	0	None	12	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397891	91067	0	None	12	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	242	1	1	2	1.5	O=C1c2c(cccc2C2CC2)C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	277	1289	62	None	-5	46	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	2913	1289	62	None	-5	46	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	765	1289	62	None	-5	46	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	CHEMBL516	1289	62	None	-5	46	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	DB00434	1289	62	None	-5	46	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
	118464420	138220	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770342	138220	0	None	26	8	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	335	1	3	5	2.8	NC1=NC2(CCCCC2)NC(Nc2cccc(Br)c2)=N1	10.1021/acs.jmedchem.5b01631
	118464421	167268	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	CHEMBL4293638	167268	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5HT2B (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	291	1	3	5	2.7	NC1=NC2(CCCCC2)NC(Nc2cccc(Cl)c2)=N1	10.1021/acsmedchemlett.8b00300
	118706294	120509	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3310118	120509	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	CHEMBL3545470	120509	0	None	7	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	311	3	3	3	1.3	COCc1cccc2c1-c1ccc(C(=O)N=C(N)N)cc1C2O	10.1016/j.bmc.2014.05.027
	44324142	206933	0	None	-25	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	427	7	2	5	3.0	COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	CHEMBL91221	206933	0	None	-25	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	427	7	2	5	3.0	COc1cc(Cl)c(Cl)cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O	10.1016/S0960-894X(96)00503-3
	10670191	40867	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	428	3	1	4	5.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	CHEMBL14864	40867	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	428	3	1	4	5.1	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3cnccc3C)c1)CC2	10.1021/jm990388c
	135398745	2893	112	None	-5	66	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	47	2893	112	None	-5	66	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	CHEMBL715	2893	112	None	-5	66	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	DB00334	2893	112	None	-5	66	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in CHO cellsDisplacement of [3H]LSD from 5HT2B receptor expressed in CHO cells	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm070516u
	44298080	195947	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	431	4	1	5	4.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55969	195947	0	None	-1	3	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	431	4	1	5	4.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3cncn3C)nc1)CC2	10.1016/s0960-894x(00)00365-6
	191	402	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	201	402	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	2170	402	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	CHEMBL1113	402	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	DB00543	402	98	None	-5	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
	118706292	120508	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3310117	120508	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	CHEMBL3545469	120508	0	None	6	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation countingDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293-EBNA cells by liquid scintillation counting	ChEMBL	297	2	4	3	0.7	NC(N)=NC(=O)c1ccc2c(c1)C(O)c1cccc(CO)c1-2	10.1016/j.bmc.2014.05.027
	127035065	136475	0	None	30	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	CHEMBL3736207	136475	0	None	30	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5-HT2B receptor stably expressed in HEK cell membrane after 90 mins by scintillation counting method	ChEMBL	477	13	0	6	5.2	COc1ccc(CCCN(CCc2ccc(OC)c(OC)c2)CCc2ccc3c(c2)OCO3)cc1	10.1039/C4MD00418C
	73453	29585	24	None	-9	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	CHEMBL1385840	29585	24	None	-9	17	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
	118729258	120670	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402671	120670	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547133	120670	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	319	2	0	1	4.7	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(C(F)(F)F)c2)C1	10.1016/j.bmc.2015.01.060
	127036186	137389	0	None	-1	19	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3753318	137389	0	None	-1	19	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	254	7	1	1	3.7	C=CCN(CC=C)CCc1c[nH]c2ccc(C)cc12	10.1016/j.bmcl.2015.12.053
	71062829	160110	0	None	1	3	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	339	6	0	5	2.2	c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1	nan
	CHEMBL4108986	160110	0	None	1	3	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	339	6	0	5	2.2	c1ccc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)nc1	nan
	10659364	120688	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3402685	120688	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3547178	120688	0	None	-50	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@@H]1C[C@@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	122187376	122998	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	457	6	0	5	5.9	CCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609141	122998	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	457	6	0	5	5.9	CCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	9978683	18642	0	None	-380	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277104	18642	0	None	-380	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	5	3.3	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)CC1	10.1021/jm1007825
	53325861	56826	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	CHEMBL1643902	56826	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmc.2013.07.045
	53325861	56826	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmcl.2010.11.075
	CHEMBL1643902	56826	0	None	-2	3	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	297	4	0	1	3.4	CN(CCc1cccc(F)c1)[C@H]1C2C3CC4C5C3CC2C5C41	10.1016/j.bmcl.2010.11.075
	117209858	184530	1	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4848305	184530	1	None	-3	7	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	262	2	2	3	2.1	Clc1cccc(-c2n[nH]cc2N2CCNCC2)c1	10.1021/acs.jmedchem.1c01093
	46230047	199227	0	None	16	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590089	199227	0	None	16	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1ccc2c(c1)C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	24839550	137290	14	None	1	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
	CHEMBL3752576	137290	14	None	1	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT 2B (unknown origin) by competition binding assayBinding affinity to 5-HT 2B (unknown origin) by competition binding assay	ChEMBL	240	7	1	1	3.4	C=CCN(CC=C)CCc1c[nH]c2ccccc12	10.1016/j.bmcl.2015.12.053
	45486891	196917	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	CHEMBL566379	196917	0	None	-83	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	449	6	3	4	4.1	O=C1Cc2c(ccc3c2OC[C@H](CNCCCC2CCc4c([nH]c5ccc(F)cc45)C2)O3)N1	10.1016/j.bmcl.2009.08.050
	27620	140793	13	None	-269	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3818994	140793	13	None	-269	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	297	5	0	2	3.8	O=C(CCCN1CCc2ccccc2C1)c1ccc(F)cc1	10.1016/j.bmc.2016.05.053
	24360	203321	106	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	CHEMBL65	203321	106	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	348	1	1	6	2.1	CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1	nan
	44315697	205482	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	CHEMBL80731	205482	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	254	4	1	3	2.6	CCSc1cc2c(cc1F)CCN2C[C@H](C)N	10.1016/j.bmcl.2003.05.001
	3952	1875	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5353646	1875	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5443	1875	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	5702063	1875	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL1331786	1875	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	CHEMBL420	1875	38	None	-3	12	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	nan
	145967771	164763	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4218231	164763	0	None	3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	223	2	2	4	1.6	C[C@H]1SC(c2ccccc2O)=N[C@@H]1CO	10.1021/acs.jnatprod.7b00317
	57396813	71516	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1949930	71516	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	CHEMBL1963007	71516	0	None	-891	5	Human	5.2	pKi	=	5.2	Binding	Inhibition of human 5HT2BInhibition of human 5HT2B	ChEMBL	403	5	1	6	3.2	COc1cc(OC(C)C)cc(S(=O)(=O)c2ccc3c(c2)O[C@H]2CNCC[C@@H]32)c1	10.1016/j.bmcl.2011.12.026
	44407335	73065	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	CHEMBL201117	73065	0	None	-7	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	321	5	1	3	4.7	C[C@@H](Cn1ccc2ccc3ncccc3c21)NCC1CCCCC1	10.1016/j.bmcl.2005.10.029
	57799321	89032	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337491	89032	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2364961	89032	1	None	-5	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@@H]2CNC[C@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	71462777	82936	0	None	-83	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	335	5	0	4	4.3	CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1	10.1021/jm300943r
	CHEMBL2181171	82936	0	None	-83	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	335	5	0	4	4.3	CCCN1CCC(COc2nc3ccccc3c3ncccc23)CC1	10.1021/jm300943r
	56658156	65637	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccccc1CCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	CHEMBL1834256	65637	0	None	9	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation countingDisplacement of [3H]LSD from 5-HT2B after 1.5 hrs by liquid scintillation counting	ChEMBL	364	7	0	4	4.2	COc1ccccc1CCCN1CCN(Cc2cc3ccccc3o2)CC1	10.1016/j.bmcl.2011.08.029
	168281486	191010	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(OCCF)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5187013	191010	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	387	6	0	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(OCCF)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	11630147	91084	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397908	91084	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	246	2	1	3	1.1	CCOc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	44298209	194568	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL53113	194568	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	395	3	1	5	4.5	Cc1cc2c(cc1Cl)N(C(=O)Nc1cnc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	44298225	195455	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	456	3	1	5	5.1	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(C(F)(F)F)c2c3CCO2)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL55292	195455	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	456	3	1	5	5.1	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3c2cc(C(F)(F)F)c2c3CCO2)cn1	10.1016/s0960-894x(00)00364-4
	44298244	200052	0	None	-79	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1cc2c(cc1Br)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL59584	200052	0	None	-79	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	438	3	1	4	5.2	Cc1cc2c(cc1Br)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2	10.1016/s0960-894x(00)00364-4
	17989871	150301	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(C)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	CHEMBL395298	150301	0	None	-50	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	462	6	0	4	5.6	COc1ccc(N2Cc3cc(Cl)c(C)c(Cl)c3C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.029
	10693974	35635	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccc(F)cc3)c1)CC2	10.1021/jm990388c
	CHEMBL14401	35635	0	None	-9	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	431	3	1	3	5.5	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cncc(-c3ccc(F)cc3)c1)CC2	10.1021/jm990388c
	10458193	86813	0	None	-25	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cc(F)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	CHEMBL232254	86813	0	None	-25	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	451	6	0	5	4.6	COc1ccc(N2Cc3c(c4cc(F)ccc4n3C)C2=O)cc1OCCN1CCC(C)CC1	10.1016/j.bmcl.2006.10.034
	44568347	191627	0	None	-30	15	Human	6.2	pKi	=	6.2	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	CHEMBL519609	191627	0	None	-30	15	Human	6.2	pKi	=	6.2	Binding	Antagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assayAntagonist activity at serotonin 5HT2B receptor (unknown origin) by PDSP assay	ChEMBL	356	6	0	4	5.2	CCN(CC)CCCOC(=O)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
	18475581	199576	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	4	4.3	Cc1nc2ccc(NC(=O)Nc3ccnc4ccccc34)cc2o1	10.1016/s0960-894x(01)00343-2
	CHEMBL59266	199576	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	318	2	2	4	4.3	Cc1nc2ccc(NC(=O)Nc3ccnc4ccccc34)cc2o1	10.1016/s0960-894x(01)00343-2
	24888180	79839	0	None	-251	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	426	7	0	4	4.6	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL212270	79839	0	None	-251	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	426	7	0	4	4.6	COc1ccc(N2CC=C(c3cccc(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	24887518	80255	0	None	-794	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	CHEMBL213987	80255	0	None	-794	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	460	7	0	4	5.3	COc1ccc(N2CC=C(c3ccc(Cl)c(Cl)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2006.05.034
	44298091	101692	0	None	-99	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	398	3	1	4	5.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL299530	101692	0	None	-99	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	398	3	1	4	5.0	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(F)c(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	10476876	194953	0	None	-158	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C(F)(F)F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL54610	194953	0	None	-158	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	414	3	1	4	5.2	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(C(F)(F)F)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	44298182	194974	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	424	3	1	4	4.9	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL54769	194974	0	None	-199	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	424	3	1	4	4.9	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3cc(Br)ccc32)cn1	10.1016/s0960-894x(00)00364-4
	10413595	161817	0	None	-1995	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	CHEMBL414628	161817	0	None	-1995	11	Human	6.2	pKi	=	6.2	Binding	Compound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligandCompound was evaluated for binding affinity against human cloned 5-HT2B receptor in HEK 293 cells using [3H]5-HT as the radioligand	ChEMBL	499	4	1	5	2.5	COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1	10.1016/s0960-894x(00)00597-7
	6918647	100718	2	None	-125	14	Human	6.2	pKi	=	6.2	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	CHEMBL292759	100718	2	None	-125	14	Human	6.2	pKi	=	6.2	Binding	Compound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HTCompound was tested for its binding affinity against cloned human 5-hydroxytryptamine 2B receptor in HEK 293 cells using [3H]5-HT	ChEMBL	439	5	1	5	3.0	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1	10.1021/jm980532e
	18931344	206511	0	None	-19	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	544	11	3	8	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1	10.1016/S0960-894X(96)00503-3
	CHEMBL88571	206511	0	None	-19	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	544	11	3	8	2.5	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccccc1	10.1016/S0960-894X(96)00503-3
	155557042	174533	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	CHEMBL4556297	174533	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	219	1	1	3	1.9	COc1ccc2c(c1)[C@@H]1CCN[C@]1(C)CO2	10.1021/acsmedchemlett.9b00225
	15124	141110	7	None	1	4	Human	5.2	pKi	=	5.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	3	2	2	2.0	CN(C)CCc1c[nH]c2cc(O)ccc12	10.1016/j.bmcl.2005.06.104
	CHEMBL382750	141110	7	None	1	4	Human	5.2	pKi	=	5.2	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	204	3	2	2	2.0	CN(C)CCc1c[nH]c2cc(O)ccc12	10.1016/j.bmcl.2005.06.104
	118055308	177738	0	None	-2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	208	0	1	2	1.8	Clc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	CHEMBL4642763	177738	0	None	-2	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	208	0	1	2	1.8	Clc1ccc2c3c1CCN3CCNC2	10.1016/j.bmcl.2019.126929
	2099	9275	55	None	-	1	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	CHEMBL1110	9275	55	None	-	1	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	nan
	25209050	181566	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	479	6	2	6	3.9	Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL477008	181566	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	479	6	2	6	3.9	Cc1c(Cn2ncc(N3CCNCC3)cc2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	11820166	40245	0	None	-5	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1cccc2[nH]cc(C3CC3N)c12	10.1021/jm980318q
	CHEMBL148091	40245	0	None	-5	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	202	2	2	2	2.0	COc1cccc2[nH]cc(C3CC3N)c12	10.1021/jm980318q
	70695812	73255	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	CHEMBL2012686	73255	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.8b01662
	71062560	153404	0	None	-1	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	352	5	0	4	2.4	O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21	nan
	CHEMBL3979116	153404	0	None	-1	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	352	5	0	4	2.4	O=C(CN1CCO[C@H](COc2ccccc2)C1)N1CCc2ccccc21	nan
	59511191	185499	3	None	-8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4862745	185499	3	None	-8	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	228	2	2	3	1.5	c1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	44276349	99976	0	None	-288	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	325	3	4	8	-0.2	CNc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	CHEMBL286739	99976	0	None	-288	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	325	3	4	8	-0.2	CNc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12	10.1021/acs.jmedchem.6b01183
	11427139	84658	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL222566	84658	0	None	-15	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	282	1	1	2	2.4	C=Cc1cc2c(c(C(F)(F)F)c1)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	2274	3151	58	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	4917	3151	58	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	7279	3151	58	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	CHEMBL728	3151	58	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	DB00433	3151	58	None	-10	32	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
	132060812	162012	0	None	-16	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	CHEMBL4160064	162012	0	None	-16	10	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	329	4	0	2	4.9	COc1cccc(-c2ccc3c(c2)CCN(Cc2ccccc2)C3)c1	10.1016/j.ejmech.2018.02.024
	44215629	156318	1	None	-12	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	206	0	1	2	1.9	N#Cc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL406585	156318	1	None	-12	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	206	0	1	2	1.9	N#Cc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	118729236	120652	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402658	120652	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547011	120652	0	None	-9	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2ccccc2Br)C1	10.1016/j.bmc.2015.01.060
	CHEMBL4513786	213944	7	None	-1174	8	Human	5.2	pKi	=	5.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2B	ChEMBL		None	None	None		CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC	10.6019/CHEMBL5212743
	CHEMBL4796803	213944	7	None	-1174	8	Human	5.2	pKi	=	5.2	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl HTR2B	ChEMBL		None	None	None		CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC	10.6019/CHEMBL5212743
	46914776	15386	0	None	7	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214892	15386	0	None	7	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	364	7	0	4	4.5	CCCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	71062708	154282	0	None	-3	12	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL3986651	154282	0	None	-3	12	Mouse	6.2	pKi	=	6.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	49865886	16148	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	262	2	1	3	2.1	CCCNC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	CHEMBL1224102	16148	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	262	2	1	3	2.1	CCCNC(=O)N1OCC2COc3ccccc3C21	10.1016/j.bmcl.2010.07.074
	11198145	9783	2	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL113830	9783	2	None	-2	5	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	49783209	17577	0	None	-114	27	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	CHEMBL1258223	17577	0	None	-114	27	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5-HT2B receptorBinding affinity to human 5-HT2B receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
	10539928	120681	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402668	120681	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547154	120681	0	None	-8	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(F)cc2)C1	10.1016/j.bmc.2015.01.060
	136118619	76222	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058418	76222	0	None	2	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	25060119	104288	0	None	-9332	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	CHEMBL3099899	104288	0	None	-9332	7	Human	6.2	pKi	=	6.2	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	493	7	1	5	6.1	COc1ccc(CNC(=O)c2cc(-c3cc(Cl)cc(Cl)c3)cnc2-c2cccnc2)cc1OC	10.1016/j.bmcl.2013.10.045
	122187377	122999	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	485	8	0	5	6.7	CCCCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609142	122999	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	485	8	0	5	6.7	CCCCCCOc1c(OC)cc2c3c1-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL5071978	214249	0	None	1	6	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCN(CC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	44397752	125243	0	None	-7	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	CHEMBL364534	125243	0	None	-7	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	216	0	1	2	2.0	Cc1ccc2c(c1C)N1[C@H](CNC[C@H]1C)C2	10.1016/j.bmcl.2005.05.074
	46230097	199343	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590816	199343	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.6	O=C1NC2CCNCCN2c2ccccc21	10.1016/j.bmcl.2009.12.014
	130442480	175246	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	175246	0	None	-83	24	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	134150123	152066	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	4	2	9	0.4	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3967613	152066	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	381	4	2	9	0.4	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N(C)C)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	3033538	1307	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	7155	1307	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	781	1307	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	CHEMBL1201216	1307	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	DB00298	1307	39	None	-12	9	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	nan
	16118795	60066	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642851	60066	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739215	60066	0	None	-954	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1cccc2ccccc12)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	16117153	60109	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1642889	60109	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	CHEMBL1739616	60109	0	None	-1122	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	406	4	3	5	3.7	O=S(=O)(c1ccc2ccccc2c1)c1n[nH]c2ccc(NC3CCNCC3)cc12	10.1016/j.bmc.2010.10.033
	70695812	73255	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	CHEMBL2012686	73255	0	None	-831	8	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	375	5	3	7	2.0	O[C@@H]1[C@H](O)[C@@H]2C[C@@H]2[C@H]1n1cnc2c(NC(C3CC3)C3CC3)nc(Cl)nc21	10.1021/acs.jmedchem.6b01183
	44352308	117461	0	None	-83	12	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	CHEMBL339980	117461	0	None	-83	12	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligandBinding affinity towards human 5-hydroxytryptamine 2B receptor using [3H]5-HT as radioligand	ChEMBL	339	5	2	2	4.0	Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C	10.1021/jm0155190
	122442272	138323	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138323	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138323	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	213	3824	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	2717	3824	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	5533	3824	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	CHEMBL621	3824	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	DB00656	3824	55	None	-5	44	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	nan
	44409097	76577	0	None	-4	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	257	0	1	3	1.8	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL206333	76577	0	None	-4	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	257	0	1	3	1.8	C[C@@H]1CNC[C@H]2Cc3ccc(C(F)(F)F)nc3N12	10.1016/j.bmcl.2005.11.083
	44626329	197385	0	None	-20	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	CHEMBL569513	197385	0	None	-20	3	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	10.1016/j.bmcl.2009.08.050
	11148641	91061	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL2397885	91061	0	None	-1	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	216	0	1	2	1.0	C[C@H]1CN2C(=O)c3ccccc3C[C@@H]2CN1	10.1016/j.bmcl.2013.04.061
	CHEMBL5091373	215544	0	None	-33	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	CHEMBL5095981	215544	0	None	-33	9	Human	7.2	pKi	=	7.2	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CNCCc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	2351	3261	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	2820	3261	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	5035	3261	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	CHEMBL81	3261	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	DB00481	3261	64	None	-7	21	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	10.1021/jm100600y
	122442272	138323	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3769968	138323	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	CHEMBL3771384	138323	0	None	-2	15	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human 5HT2B receptor by radioligand binding assayBinding affinity to human 5HT2B receptor by radioligand binding assay	ChEMBL	239	5	1	2	2.6	C=CCOc1cc(F)c(F)cc1C1CC1CN	10.1021/acs.jmedchem.5b01153
	9909648	205550	3	None	-22	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm100600y
	CHEMBL81330	205550	3	None	-22	12	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm100600y
	145977799	163619	0	None	1	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4204036	163619	0	None	1	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	257	3	1	3	2.9	C[C@@H]1SC(c2ccccc2)=N[C@@H]1Cc1c[nH]cn1	10.1021/acs.jnatprod.7b00317
	CHEMBL4778870	214024	8	None	-1	5	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1	10.6019/CHEMBL4800732
	12488	1644	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	941361	1644	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	CHEMBL30008	1644	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	DB04841	1644	56	None	-11	23	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
	53324553	56825	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	CHEMBL1643900	56825	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5-HT2B receptor (unknown origin) by PDSP assayInhibition of 5-HT2B receptor (unknown origin) by PDSP assay	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmc.2013.07.045
	53324553	56825	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	CHEMBL1643900	56825	0	None	-9	10	Human	5.2	pKi	=	5.2	Binding	Inhibition of 5HT2B receptorInhibition of 5HT2B receptor	ChEMBL	283	4	1	1	3.1	Fc1cccc(CCN[C@H]2C3C4CC5C6C4CC3C6C52)c1	10.1016/j.bmcl.2010.11.075
	CHEMBL4778870	214024	8	None	-1	5	Human	6.2	pKi	=	6.2	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		CC1CCN(c2ccnc(NCc3cn(C)cn3)n2)CC1	10.6019/CHEMBL4800732
	16115271	79079	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	CHEMBL2113264	79079	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	298	1	1	2	2.8	CC(C)[C@H]1CNC[C@H]2c3cccc(C(F)(F)F)c3C(=O)N12	10.1021/jm0612968
	71720492	86939	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	493	8	2	5	3.0	C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/ml3003814
	CHEMBL2323578	86939	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	ChEMBL	493	8	2	5	3.0	C=CCN1C[C@H](C(=O)N(CCCN2CCOCC2)C(=O)NCC)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/ml3003814
	135398737	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	38	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	722	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	CHEMBL42	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	DB00363	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
	9803032	191429	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
	CHEMBL5193178	191429	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constantBinding affinity to 5-HT2B receptor (unknown origin) assessed as inhibition constant	ChEMBL	435	7	0	4	4.4	COc1ccccc1N1CCN(CC[C@@H](C(=O)N2CCCCCC2)c2ccccc2)CC1	10.1021/acs.jmedchem.2c00633
	3649661	138194	7	None	23	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	CHEMBL3770106	138194	7	None	23	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) after 1.5 hrs by microbeta scintillation counting method	ChEMBL	329	3	3	7	2.2	CCOC(=O)c1cccc(NC2=NC(N)=NC3(CCCCC3)N2)c1	10.1021/acs.jmedchem.5b01631
	2247	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	249	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	2603	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	CHEMBL296419	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	DB00637	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
	11708275	72683	3	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	CHEMBL199775	72683	3	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	3	1	4	1.4	COc1ccc2cnn(C[C@H](C)N)c2c1	10.1021/jm050663x
	134	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	1775	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	9681	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	CHEMBL1065	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	DB00247	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	134	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	1775	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	9681	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	CHEMBL1065	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	DB00247	2497	24	None	-2	68	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1016/j.bmcl.2013.12.024
	11949710	199879	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	CHEMBL594717	199879	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	355	4	1	4	3.5	Cc1ccc(F)cc1CO[C@H]1CCc2ccc(N3CCNC[C@H]3C)nc21	10.1016/j.bmcl.2009.10.112
	36906	104853	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	CHEMBL31115	104853	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm050663x
	36906	104853	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm030205t
	CHEMBL31115	104853	75	None	-1	5	Human	8.1	pKi	=	8.1	Binding	Inhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligandInhibitory constant against cloned human 5-hydroxytryptamine 2B receptor using with [125I]- DOI radioligand	ChEMBL	204	3	2	2	2.1	COc1ccc2[nH]cc(CC(C)N)c2c1	10.1021/jm030205t
	44573547	187608	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assayBinding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assay	ChEMBL	348	5	1	5	2.6	C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F	10.1021/acs.jmedchem.2c00633
	CHEMBL494948	187608	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assayBinding affinity to human recombinant 5-HT2B expressed in HEK293 cells assessed as inhibition constant by radioligand binding assay	ChEMBL	348	5	1	5	2.6	C[C@H](Cc1cccc(F)c1)Oc1nc(N2CCNC[C@H]2C)ncc1F	10.1021/acs.jmedchem.2c00633
	9931534	34079	0	None	-7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL14255	34079	0	None	-7	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	413	3	1	3	5.4	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10623205	99039	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	445	3	1	3	5.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL280465	99039	0	None	-12	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	445	3	1	3	5.8	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc(F)c(C)c(-c3cccnc3)c1)CC2	10.1021/jm990388c
	10837468	162684	0	None	-15	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	455	3	1	4	5.3	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2	10.1021/jm990388c
	CHEMBL417082	162684	0	None	-15	3	Human	8.1	pKi	=	8.1	Binding	Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.Binding affinities towards human cloned 5-hydroxytryptamine 2B receptor in HEK293 cells using [3H]5-HT as radioligand.	ChEMBL	455	3	1	4	5.3	COc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cc3c(c(-c4cccnc4)c1)OCC3)CC2	10.1021/jm990388c
	10622480	167012	0	None	-5	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	CHEMBL428879	167012	0	None	-5	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5-hydroxytryptamine 2B receptor expressed in HEK293 cells	ChEMBL	429	3	1	3	6.1	CSc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cccc(-c3cccnc3)c1)CC2	10.1021/jm990388c
	44298176	100600	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL291949	100600	0	None	-6	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	394	4	1	4	4.6	Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(OCc3ccncc3)nc1)CC2	10.1016/s0960-894x(00)00365-6
	18357730	195886	0	None	-19	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL55914	195886	0	None	-19	3	Human	8.1	pKi	=	8.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	442	4	1	4	5.3	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(OCc3ccccn3)c(C)c1)CC2	10.1016/s0960-894x(00)00365-6
	44453103	98033	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	296	4	1	4	2.9	CCN(CC)c1nc2c(c(-c3ccc(C)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL273173	98033	0	None	-3	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity at 5HT2B receptorBinding affinity at 5HT2B receptor	ChEMBL	296	4	1	4	2.9	CCN(CC)c1nc2c(c(-c3ccc(C)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	240	941	43	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	2769	941	43	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	44279790	941	43	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	660	941	43	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL1729	941	43	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	CHEMBL560739	941	43	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	DB00604	941	43	None	-6	25	Human	7.2	pKi	=	7.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	nan
	11737939	84198	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL220900	84198	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	2.1	O=C1c2c(ccc(Cl)c2Cl)[C@@H]2CNCCN12	10.1021/jm0612968
	118729268	120675	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402677	120675	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547138	120675	0	None	-22	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	269	2	0	1	3.8	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(F)c2)C1	10.1016/j.bmc.2015.01.060
	118729254	120682	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402669	120682	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547155	120682	0	None	-6	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	296	3	0	3	3.6	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc([N+](=O)[O-])c2)C1	10.1016/j.bmc.2015.01.060
	16062136	157644	4	None	-13	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	1	1	3	3.2	CC(C)(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	CHEMBL408155	157644	4	None	-13	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	285	1	1	3	3.2	CC(C)(C)c1nc2c(c(-c3ccc(F)cc3)n1)CNCC2	10.1016/j.bmcl.2008.01.090
	146159245	188426	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	451415	188426	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	86289437	188426	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	CHEMBL502620	188426	30	None	-	1	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	nan
	12613159	187302	11	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL493054	187302	11	None	-2	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	10517285	120686	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402683	120686	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547176	120686	0	None	-14	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccccc2Cl)C1	10.1016/j.bmc.2015.01.060
	1224	1420	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	3100	1420	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	8980	1420	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	916	1420	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	CHEMBL657	1420	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	DB01075	1420	83	None	-6	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	nan
	122187381	123002	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	401	2	1	5	4.5	COc1cc2c3c(c1O)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3609146	123002	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	401	2	1	5	4.5	COc1cc2c3c(c1O)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	135465870	188967	8	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL508657	188967	8	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	254	1	2	2	1.6	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccccc23)N1C	10.1016/j.bmc.2013.09.011
	155565326	175561	0	None	-467	7	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	462	6	5	9	0.5	O=C(NCCO)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4579650	175561	0	None	-467	7	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	462	6	5	9	0.5	O=C(NCCO)[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@H]4C[C@H]5CC[C@@H]4C5)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	46914620	15401	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1214962	15401	0	None	6	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	350	6	0	4	4.1	CCOc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	46230094	199288	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
	CHEMBL590482	199288	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	237	0	2	3	0.8	O=C1NC2CNCCN2c2ccc(Cl)cc21	10.1016/j.bmcl.2009.12.014
	57403525	70125	0	None	-478	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940402	70125	0	None	-478	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	127051845	140704	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140704	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	4178	195780	63	None	-	1	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	CHEMBL558	195780	63	None	-	1	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	nan
	127051845	140704	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	CHEMBL3817898	140704	0	None	-42	9	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor expressed in cell membranes after 1 hr by liquid scintillation counting	ChEMBL	309	6	0	3	3.7	COc1ccc(C(=O)CCCN2CCc3ccccc3C2)cc1	10.1016/j.bmc.2016.05.053
	145986752	167252	0	None	-1	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
	CHEMBL4293307	167252	0	None	-1	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
	11695000	89042	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337490	89042	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365083	89042	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	256	0	2	2	1.5	O=C1N[C@H]2CNC[C@@H]2c2cccc(C(F)(F)F)c21	10.1016/j.bmcl.2012.10.091
	118729276	120663	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402682	120663	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547045	120663	0	None	-14	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	327	3	0	1	5.4	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(-c3ccccc3)c2)C1	10.1016/j.bmc.2015.01.060
	134152157	153115	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	CHEMBL3976579	153115	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	393	6	4	8	1.4	CC[C@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CO)C[C@H]12)C1CC1	10.1021/acs.jmedchem.6b01183
	21830793	91806	10	None	-489	46	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	CHEMBL2413154	91806	10	None	-489	46	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	10.1016/j.bmc.2013.05.050
	16115392	84768	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL223292	84768	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	236	0	1	2	1.7	Cc1ccc(Cl)c2c1[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	11665991	199321	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CNCCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	CHEMBL590721	199321	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	251	0	2	3	1.2	O=C1NC2CNCCCN2c2cccc(Cl)c21	10.1016/j.bmcl.2009.12.014
	222757	99348	73	None	-1	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	CHEMBL282575	99348	73	None	-1	3	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	nan
	2812	4747	101	None	-40	34	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	CHEMBL104	4747	101	None	-40	34	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
	44407440	139281	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL379223	139281	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	329	5	1	3	4.7	Cc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	24740863	89129	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
	CHEMBL236610	89129	0	None	1	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	10.1016/j.bmcl.2009.09.024
	46214153	110668	0	None	-6	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	CHEMBL3260334	110668	0	None	-6	5	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	367	5	1	3	4.0	Clc1cccc(COc2ccc(Br)cc2OC2CNC2)c1	10.1021/ml500082j
	11221167	84651	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL222514	84651	0	None	-10	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	256	0	1	2	1.8	O=C1c2c(cccc2C(F)(F)F)[C@@H]2CNCCN12	10.1021/jm0612968
	CHEMBL4520788	213952	10	None	-3	25	Human	7.1	pKi	=	7.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR2BSelectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR2B	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
	155535754	172051	0	None	13	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	301	1	1	4	1.2	Cc1cccc(C)c1N1C(=O)CNC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4472251	172051	0	None	13	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	301	1	1	4	1.2	Cc1cccc(C)c1N1C(=O)CNC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	44404906	70241	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	2	2	2.4	CC(Cc1c[nH]c2cccc(O)c12)N(C)C	10.1016/j.bmcl.2005.06.104
	CHEMBL194202	70241	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	3	2	2	2.4	CC(Cc1c[nH]c2cccc(O)c12)N(C)C	10.1016/j.bmcl.2005.06.104
	24873261	183170	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	CHEMBL4795756	183170	0	None	-1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assayDisplacement of [3H]-ketanserin from human 5-HT2B receptor by competitive radioligand binding assay	ChEMBL	241	2	1	3	2.3	CCn1nc2c(c1-c1ccccc1)CCNCC2	10.1016/j.bmcl.2020.127669
	16115644	136935	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL374436	136935	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	246	2	1	3	1.4	CCc1cc2c(cc1OC)C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	145964150	164282	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	CHEMBL4212246	164282	0	None	-3	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	279	6	1	4	3.1	CCCCOc1ccc(C2=N[C@@H](CO)[C@H](C)S2)cc1	10.1021/acs.jnatprod.7b00317
	118567543	171344	0	None	-7	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	463	4	0	4	4.2	O=C1N(c2cccnc2C(F)(F)F)CC2(CCN(CCc3ccccc3F)CC2)OC12CC2	10.1021/acs.jmedchem.9b01256
	CHEMBL4461774	171344	0	None	-7	3	Human	6.1	pKi	=	6.1	Binding	Inhibition of 5HT2B receptor (unknown origin)Inhibition of 5HT2B receptor (unknown origin)	ChEMBL	463	4	0	4	4.2	O=C1N(c2cccnc2C(F)(F)F)CC2(CCN(CCc3ccccc3F)CC2)OC12CC2	10.1021/acs.jmedchem.9b01256
	88912137	110671	0	None	-245	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	CHEMBL3260337	110671	0	None	-245	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	405	5	1	3	5.2	C[C@@H](Oc1ccc(C(F)(F)F)cc1OC1CNC1)c1cccc(C(F)(F)F)c1	10.1021/ml500082j
	122188580	123159	0	None	-19	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	485	5	4	8	2.4	CCCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.9b00637
	CHEMBL3612941	123159	0	None	-19	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	485	5	4	8	2.4	CCCNc1cc(C#Cc2ccc(Cl)s2)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(C(=O)NC)C[C@H]12	10.1021/acsmedchemlett.9b00637
	71062889	148250	0	None	-41	5	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	CHEMBL3936595	148250	0	None	-41	5	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	44409096	76746	0	None	-28	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	203	0	1	3	1.1	Cc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL206845	76746	0	None	-28	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	203	0	1	3	1.1	Cc1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	134138769	147646	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	CHEMBL3931747	147646	0	None	1	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting methodDisplacement of [3H]lysergic from human 5-HT2BR expressed in HEK cell membranes incubated in dark for 90 mins by microbeta scintillation counting method	ChEMBL	419	6	4	8	1.7	OC[C@@]12C[C@@H]1[C@@H](n1cnc3c(N[C@@H](C4CCC4)C4CC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.6b01183
	132559161	172998	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2b (unknown origin)Binding affinity to 5HT2b (unknown origin)	ChEMBL	538	7	2	7	1.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccoc2)N(C)C(=O)[C@H](Cc2ccoc2)NC(=O)[C@H](Cc2ccoc2)N(C)C1=O	10.1039/C9MD00050J
	CHEMBL4518571	172998	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2b (unknown origin)Binding affinity to 5HT2b (unknown origin)	ChEMBL	538	7	2	7	1.8	CC(C)[C@@H]1NC(=O)[C@H](Cc2ccoc2)N(C)C(=O)[C@H](Cc2ccoc2)NC(=O)[C@H](Cc2ccoc2)N(C)C1=O	10.1039/C9MD00050J
	90181066	160139	0	None	9	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	380	5	0	4	3.1	Cc1ccccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	CHEMBL4109218	160139	0	None	9	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	380	5	0	4	3.1	Cc1ccccc1OC[C@H]1CN(CC(=O)N2c3ccccc3CC2C)CCO1	nan
	136118652	93024	0	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cccc(Br)c23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442266	93024	0	None	3	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3cccc(Br)c23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	11673842	89059	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337498	89059	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365254	89059	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	264	2	2	2	2.1	CCCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	11361103	91076	1	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397900	91076	1	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	270	0	1	2	1.7	O=C1c2ccc(C(F)(F)F)cc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	18715554	74395	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL202656	74395	0	None	-10	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	225	2	1	3	2.5	C[C@H](N)Cn1ccc2ccc3cnccc3c21	10.1016/j.bmcl.2005.10.029
	24826871	91083	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397907	91083	0	None	1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	232	1	1	3	0.7	COc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	25122653	200504	0	None	-17	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	440	3	2	5	4.1	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5c(Cl)cccc45)c3c2)CC1	10.1021/jm901674f
	CHEMBL598850	200504	0	None	-17	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	440	3	2	5	4.1	NC1CCN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5c(Cl)cccc45)c3c2)CC1	10.1021/jm901674f
	136118638	76287	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058698	76287	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3cccc(Br)c23)N1	10.1016/j.bmc.2013.09.011
	136118730	76215	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	CHEMBL2058407	76215	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2cccc(Br)c12	10.1016/j.bmc.2013.09.011
	71062567	160391	0	None	2	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	CHEMBL4111349	160391	0	None	2	2	Mouse	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	6	0	5	2.5	Cc1ccnc(OC[C@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
	54764239	68837	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	CHEMBL1922537	68837	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 minsInhibition of human 5HT2B receptor expressed in cos-7 cells assessed as [3H]5-HT uptake after 120 mins	ChEMBL	272	2	1	3	2.7	CC/C=C1\C[C@H]2CNc3c(OC)cccc3C(=O)N2C1	10.1016/j.bmcl.2011.09.086
	11630623	89070	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337499	89070	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2365399	89070	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1ccc(Cl)c2c1[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	56649649	67828	0	None	-93	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910140	67828	0	None	-93	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	480	8	0	5	4.6	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)CC3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	86221574	166663	2	None	9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	375	5	2	2	3.4	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1	10.1039/C8MD00204E
	CHEMBL4282117	166663	2	None	9	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting methodDisplacement of [3H]LSD from human 5HT2B receptor expressed in HEK cells membranes after 1.5 hrs by liquid scintillation counting method	ChEMBL	375	5	2	2	3.4	O=C(NCCc1c[nH]c2ccccc12)C1CCN(C(=O)c2ccccc2)CC1	10.1039/C8MD00204E
	162674022	183197	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	CHEMBL4796102	183197	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Antagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assayAntagonist activity at 5HT2B receptor (unknown origin) by radioligand binding assay	ChEMBL	305	4	1	4	3.5	N#Cc1cccc(CCCc2cc(=O)c3c(O)cccc3o2)c1	10.1016/j.bmcl.2020.127511
	44299663	163102	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	306	3	2	3	3.9	CN(C)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	CHEMBL417753	163102	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against 5-hydroxytryptamine 2B receptorBinding affinity against 5-hydroxytryptamine 2B receptor	ChEMBL	306	3	2	3	3.9	CN(C)c1ccc(NC(=O)Nc2ccnc3ccccc23)cc1	10.1016/s0960-894x(01)00343-2
	10127939	72213	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	477	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL198171	72213	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	477	7	0	4	5.3	COc1ccc(N2CCN(c3ccc(C)c(C(F)(F)F)c3)C2=O)cc1OCCN1CCCCC1	10.1016/j.bmcl.2005.08.004
	49850772	56369	0	None	-501	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1631545	56369	0	None	-501	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	397	5	0	5	4.1	Cc1ccc2c(N3CCN(CCc4cccc(-n5cccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	44298208	194663	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cn1)CC2	10.1016/s0960-894x(00)00364-4
	CHEMBL53308	194663	0	None	-39	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	429	3	1	5	4.9	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1cnc(Oc3cccnc3C)cn1)CC2	10.1016/s0960-894x(00)00364-4
	18931357	206565	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(Cl)cc1	10.1016/S0960-894X(96)00503-3
	CHEMBL88894	206565	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cellsDisplacement of [3H]-5-5HT from human cloned 5-hydroxytryptamine 2B receptor expressed in CHO-K1 cells	ChEMBL	578	11	3	8	3.2	COc1cc(OC)c(C(=O)CCCCN2CCC3(CC2)NC(=O)NC3=O)cc1NS(=O)(=O)c1ccc(Cl)cc1	10.1016/S0960-894X(96)00503-3
	153287568	170961	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	CHEMBL4456195	170961	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	217	0	1	2	2.5	Cc1cc(C)c2c(c1)OC[C@@]1(C)NCC[C@@H]21	10.1021/acsmedchemlett.9b00225
	12017598	168093	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nn1)CC2	10.1016/s0960-894x(00)00365-6
	CHEMBL432879	168093	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]5-HT displacement.	ChEMBL	429	4	1	5	4.4	Cc1cc2c(cc1C(F)(F)F)N(C(=O)Nc1ccc(OCc3ccccn3)nn1)CC2	10.1016/s0960-894x(00)00365-6
	21533446	70126	0	None	-213	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	CHEMBL1940403	70126	0	None	-213	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
	117209964	186110	1	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4871980	186110	1	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	246	2	2	3	1.6	Fc1ccc(-c2n[nH]cc2N2CCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	10194524	72523	0	None	-63	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	415	7	0	5	3.0	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	CHEMBL199177	72523	0	None	-63	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HTBinding affinity for human 5-hydroxytryptamine 2B receptor expressed in HEK 293 cells using [3H]5-HT	ChEMBL	415	7	0	5	3.0	COc1ccc(N2CCN(c3cccc(F)c3)C2=O)cc1OCCN1CCOCC1	10.1016/j.bmcl.2005.08.004
	49850567	56439	0	None	-3981	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	CHEMBL1632217	56439	0	None	-3981	9	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human recombinant 5-HT2B receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT2B receptor by radioligand displacement assay	ChEMBL	452	6	1	6	4.0	Cc1ccc2c(N3CCN(CCc4cccc(NC(=O)c5cnccn5)c4)CC3)cccc2n1	10.1021/jm100714c
	44298142	101718	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	CHEMBL299726	101718	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HTBinding affinity towards human cloned 5-HT2B receptor of HEK293 cells by displacement of [3H]5-HT	ChEMBL	380	3	1	4	4.8	Cc1ncccc1Oc1ccc(NC(=O)N2CCc3ccc(Cl)cc32)cn1	10.1016/s0960-894x(00)00364-4
	153287574	175223	0	None	-10	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	CHEMBL4572167	175223	0	None	-10	10	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor stably expressed in HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	266	2	1	2	4.0	CC[C@H]1c2ccccc2N(c2ccccc2)C[C@@]1(C)N	10.1021/acsmedchemlett.9b00225
	10368126	86690	0	None	-25	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	449	7	0	6	4.2	COc1ccc2c(c1)c1c(n2C)CN(c2ccc(OC)c(OCCN3CCCCC3)c2)C1=O	10.1016/j.bmcl.2006.10.034
	CHEMBL231833	86690	0	None	-25	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293 cells	ChEMBL	449	7	0	6	4.2	COc1ccc2c(c1)c1c(n2C)CN(c2ccc(OC)c(OCCN3CCCCC3)c2)C1=O	10.1016/j.bmcl.2006.10.034
	25164129	161136	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4088036	161136	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	CHEMBL4117406	161136	0	None	-1479	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	ChEMBL	447	12	1	5	4.1	CCCCc1cc(OC2CCN(CCCCNS(=O)(=O)CC)CC2)c2ncccc2c1	10.1016/j.bmcl.2017.09.020
	25056080	65660	0	None	-407	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	342	3	1	3	2.3	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC(C)(C)C=N1	10.1021/jm200466r
	CHEMBL1834345	65660	0	None	-407	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of human 5-HT2B receptorInhibition of human 5-HT2B receptor	ChEMBL	342	3	1	3	2.3	CCN/C(=N\S(=O)(=O)c1cccc(Cl)c1)N1CC(C)(C)C=N1	10.1021/jm200466r
	24826788	91069	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	CHEMBL2397893	91069	0	None	7	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	236	0	1	2	1.3	O=C1c2c(Cl)cccc2C[C@@H]2CNCCN12	10.1016/j.bmcl.2013.04.061
	71657836	120671	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402673	120671	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547134	120671	0	None	-1	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	329	2	0	1	4.5	CN(C)[C@@H]1Cc2ccccc2[C@@H](c2cccc(Br)c2)C1	10.1016/j.bmc.2015.01.060
	135453290	133581	33	None	-2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	CHEMBL371300	133581	33	None	-2	8	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	191	2	2	4	1.1	C[C@H](N)Cn1ncc2ccc(O)cc21	10.1021/jm050663x
	134551	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	271	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	885	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	CHEMBL1403281	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
	30241	42014	16	None	-8	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	204	3	2	2	2.2	COc1ccc2[nH]cc(C(C)CN)c2c1	10.1021/jm980318q
	CHEMBL149564	42014	16	None	-8	3	Human	8.1	pKi	=	8.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	204	3	2	2	2.2	COc1ccc2[nH]cc(C(C)CN)c2c1	10.1021/jm980318q
	11492162	72024	3	None	10	4	Human	8.1	pKi	=	8.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL197646	72024	3	None	10	4	Human	8.1	pKi	=	8.1	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	206	3	1	1	2.4	CN(C)CCc1c[nH]c2cccc(F)c12	10.1016/j.bmcl.2005.06.104
	11615459	199225	0	None	10	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	CHEMBL590078	199225	0	None	10	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cellsDisplacement of [125I]LSD from human recombinant 5HT2B receptor expressed in HEK293E cells	ChEMBL	217	0	2	3	0.5	Cc1cccc2c1C(=O)NC1CNCCN21	10.1016/j.bmcl.2009.12.014
	135414348	72780	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL200104	72780	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells	ChEMBL	205	2	2	4	1.4	Cc1c(O)ccc2cnn(C[C@H](C)N)c12	10.1021/jm050663x
	CHEMBL5082177	214769	0	None	5	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to 5-HT2BR (unknown origin)Binding affinity to 5-HT2BR (unknown origin)	ChEMBL		None	None	None		CCCN(CCC)Cc1ccc(Cl)c(-c2ccccc2OC)c1	10.1021/acs.jmedchem.1c00110
	2726	916	68	None	-19	73	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	621	916	68	None	-19	73	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	83	916	68	None	-19	73	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	CHEMBL71	916	68	None	-19	73	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	DB00477	916	68	None	-19	73	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
	122178698	121339	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL3581244	121339	0	None	-1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	369	5	0	5	3.9	CCOc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	10827035	120679	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3402666	120679	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	CHEMBL3547152	120679	0	None	-13	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	285	2	0	1	4.3	CN(C)[C@H]1Cc2ccccc2[C@H](c2ccc(Cl)cc2)C1	10.1016/j.bmc.2015.01.060
	118729281	120658	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3402686	120658	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	CHEMBL3547018	120658	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	265	2	0	1	4.0	Cc1ccccc1[C@H]1C[C@H](N(C)C)Cc2ccccc21	10.1016/j.bmc.2015.01.060
	44409316	74992	0	None	-102	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@H]2Cc3ccc(Br)nc3N12	10.1016/j.bmcl.2005.11.083
	CHEMBL203393	74992	0	None	-102	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	267	0	1	3	1.6	C[C@@H]1CNC[C@H]2Cc3ccc(Br)nc3N12	10.1016/j.bmcl.2005.11.083
	145965940	164174	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	2	2	4	2.8	C[C@@H]1SC(c2cc3ccccc3cc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	CHEMBL4210787	164174	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysisDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in HEK cells after 90 mins by microbeta scintillation counting analysis	ChEMBL	273	2	2	4	2.8	C[C@@H]1SC(c2cc3ccccc3cc2O)=N[C@H]1CO	10.1021/acs.jnatprod.7b00317
	100	3776	58	None	-11	56	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	2637	3776	58	None	-11	56	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	5452	3776	58	None	-11	56	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	CHEMBL479	3776	58	None	-11	56	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	DB00679	3776	58	None	-11	56	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
	168277348	190275	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5175973	190275	0	None	-1	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	425	8	0	5	5.4	CCCCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	155558726	174784	0	None	-19	4	Human	5.1	pKi	=	5.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	CHEMBL4562303	174784	0	None	-19	4	Human	5.1	pKi	=	5.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
	3042	1402	35	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	355	1402	35	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	868	1402	35	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	CHEMBL1123	1402	35	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	DB00804	1402	35	None	-39	15	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	nan
	122483275	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3764133	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	CHEMBL3765875	138085	0	None	-3	8	Human	7.1	pKi	=	7.1	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	427	6	1	5	5.1	O=C(CCCCN1CCN(c2ccccc2O)CC1)n1c2ccccc2c2ccccc21	10.1016/j.ejmech.2016.01.043
	11949706	200032	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	CHEMBL595645	200032	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsDisplacement of [125I]DOI from human 5HT2B receptor expressed in CHO cells	ChEMBL	359	4	1	4	3.4	C[C@@H]1CNCCN1c1ccc2c(n1)[C@@H](OCc1cc(F)ccc1F)CC2	10.1016/j.bmcl.2009.10.112
	3037629	184548	18	None	1	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	CHEMBL4848517	184548	18	None	1	10	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to controlDisplacement of [3H]LSD from human recombinant 5-HT2B receptor expressed in HEK cells by radioligand completion assay relative to control	ChEMBL	396	5	1	5	3.6	C=C[C@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1/C(=C\OC)C(=O)OC	10.1021/acs.jmedchem.1c00726
	130442572	171884	0	None	-17	24	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	171884	0	None	-17	24	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5HT2B receptor stably expressed in HEK cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	5591	157507	90	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	CHEMBL408	157507	90	None	1	2	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	nan
	21044398	141059	0	None	-21	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	1	2	4	0.9	C[C@H](O)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	CHEMBL382618	141059	0	None	-21	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]5HT from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	233	1	2	4	0.9	C[C@H](O)c1ccc2c(n1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.11.083
	46945446	17730	0	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 5-HT2B receptorInhibition of 5-HT2B receptor	ChEMBL	408	9	0	5	4.6	CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1	10.1016/j.bmcl.2010.07.135
	CHEMBL1258723	17730	0	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 5-HT2B receptorInhibition of 5-HT2B receptor	ChEMBL	408	9	0	5	4.6	CCCCOc1ccc(-c2nn3c(C)cc(C)nc3c2CC(=O)N(CC)CC)cc1	10.1016/j.bmcl.2010.07.135
	136118657	93027	0	None	12	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3c(Br)cccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2442269	93027	0	None	12	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1/N/C(=C/c2c[nH]c3c(Br)cccc23)C(=O)N1C	10.1016/j.bmc.2013.09.011
	44451393	156648	1	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	211	1	1	2	2.0	COc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	CHEMBL406957	156648	1	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	211	1	1	2	2.0	COc1ccc2c(c1Cl)CCNCC2	10.1016/j.bmc.2007.12.009
	11437171	83461	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	CHEMBL220207	83461	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	234	1	1	3	1.5	CSc1cccc2c1C(=O)N1CCNCC21	10.1021/jm0612968
	155558968	174794	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	432	3	2	5	3.2	Cc1cccc(C)c1N1C(=O)[C@H](CC2CNc3ccccc32)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	CHEMBL4562437	174794	0	None	-1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	ChEMBL	432	3	2	5	3.2	Cc1cccc(C)c1N1C(=O)[C@H](CC2CNc3ccccc32)NC2(CCN(C)CC2)C1=O	10.1016/j.ejmech.2018.12.048
	44572802	12412	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL1186019	12412	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	CHEMBL445747	12412	2	None	3	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	161	2	1	1	2.1	Cc1cccc([C@H]2C[C@@H]2CN)c1	10.1021/jm801354e
	136016509 136118731	10929	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	CHEMBL1173331	10929	0	None	2	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccc(Br)cc12	10.1016/j.bmc.2013.09.011
	3168	9230	92	None	-107	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	CHEMBL1108	9230	92	None	-107	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
	71450550	83778	0	None	-1	16	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	CHEMBL2205836	83778	0	None	-1	16	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptorBinding affinity to 5-HT2B receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
	1971	2846	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	2404	2846	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	4543	2846	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	CHEMBL445	2846	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	DB00540	2846	38	None	-4	30	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
	11300712	141661	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	CHEMBL385577	141661	0	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1c(Cl)ccc2c1C(=O)N1CCNC[C@@H]21	10.1021/jm0612968
	59757162	106277	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
	CHEMBL3092761	106277	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
	CHEMBL3139074	106277	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	ChEMBL	267	1	3	2	1.2	NC(N)=NC(=O)c1ccc2c(c1)-c1ccccc1C2O	10.1016/j.bmc.2013.10.010
	1548953	207656	27	None	-4	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	CHEMBL954	207656	27	None	-4	17	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
	5870	31630	92	None	-	1	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	CHEMBL1405	31630	92	None	-	1	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	nan
	6452095	40673	18	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	174	2	2	1	2.2	CC(CN)c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL148463	40673	18	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	174	2	2	1	2.2	CC(CN)c1c[nH]c2ccccc12	10.1021/jm980318q
	11493484	89041	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2337106	89041	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	CHEMBL2365079	89041	0	None	-2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	284	1	2	2	2.1	CCc1cc2c(c(C(F)(F)F)c1)C(=O)N[C@H]1CNC[C@H]21	10.1016/j.bmcl.2012.10.091
	21509921	104431	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104091	104431	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	44554395	18691	0	None	-54	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	CHEMBL1277565	18691	0	None	-54	7	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	406	3	1	6	3.0	Cn1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	21509921	104431	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	CHEMBL3104091	104431	0	None	-8	24	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)Displacement of [3H]LSD from 5-HT2B receptor (unknown origin)	ChEMBL	288	0	0	2	3.7	CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1	10.1016/j.bmcl.2013.12.024
	155565189	175541	0	None	-6	4	Human	6.1	pKi	=	6.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	CHEMBL4579120	175541	0	None	-6	4	Human	6.1	pKi	=	6.1	Binding	Antagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assayAntagonist activity at human recombinant 5-HT2B receptor in CHOK1 cells measured after 30 mins by HTRF assay	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
	18735309	205410	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	CHEMBL80246	205410	0	None	-3	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	262	2	1	2	2.6	C[C@H](N)CN1CCc2cc(F)c(C(F)(F)F)cc21	10.1016/j.bmcl.2003.05.001
	53381002	65435	0	None	15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	CHEMBL1829959	65435	0	None	15	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation countingDisplacement of [3H]LSD from 5-HT2B receptor after 1.5 hrs by scintillation counting	ChEMBL	240	2	2	4	2.2	COc1cccc2[nH]cc(-c3ccnc(N)n3)c12	10.1016/j.bmc.2011.08.033
	56649650	67829	0	None	-100	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910141	67829	0	None	-100	8	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	466	8	0	5	4.2	COc1ccccc1N1CCN(CCN(C(=O)C23CCC(CF)(CC2)C3)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	71062530	160068	0	None	-3	2	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	CHEMBL4108620	160068	0	None	-3	2	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	353	5	0	5	1.8	O=C(CN1CCO[C@@H](COc2cccnc2)C1)N1CCc2ccccc21	nan
	44407327	141222	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	CHEMBL383042	141222	0	None	-5	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]5-HT from human 5HT2BDisplacement of [3H]5-HT from human 5HT2B	ChEMBL	345	6	1	4	4.4	COc1ccccc1CN[C@@H](C)Cn1ccc2ccc3ncccc3c21	10.1016/j.bmcl.2005.10.029
	136118617	76220	0	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058416	76220	0	None	1	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3ccc(Br)cc23)N1C	10.1016/j.bmc.2013.09.011
	44315993	172853	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	CHEMBL451543	172853	0	None	-15	3	Human	7.1	pKi	=	7.1	Binding	Affinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell lineAffinity for human 5-hydroxytryptamine 2B receptor expressed in mammalian cell line	ChEMBL	222	3	1	3	2.1	CSc1ccc2c(c1)N(C[C@H](C)N)CC2	10.1016/j.bmcl.2003.05.001
	44572810	12623	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL1187196	12623	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	CHEMBL493130	12623	2	None	2	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]LSD from human 5HT2B receptorDisplacement of [3H]LSD from human 5HT2B receptor	ChEMBL	165	2	1	1	1.9	NC[C@H]1C[C@@H]1c1ccc(F)cc1	10.1021/jm801354e
	11346775	83452	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL220157	83452	0	None	-4	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsDisplacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cells	ChEMBL	252	1	1	3	1.4	COc1cc(Cl)c2c(c1)[C@@H]1CNCCN1C2=O	10.1021/jm0612968
	CHEMBL5094181	215457	22	None	-2	5	Human	6.1	pKi	=	6.1	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
	132060776	162378	0	None	-3	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
	CHEMBL4165863	162378	0	None	-3	16	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-LSD from human 5-HT2B receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting method	ChEMBL	419	4	0	4	4.4	O=C(OCc1ccccc1)N1CCc2ccc(N3CCN(C4CCCC4)CC3)cc2C1	10.1016/j.ejmech.2018.02.024
	136118658	76225	0	None	2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058426	76225	0	None	2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL5094181	215457	22	None	-2	5	Human	6.1	pKi	=	6.1	Binding	GPCRScan assay: inhibition of 5-HT2BGPCRScan assay: inhibition of 5-HT2B	ChEMBL		None	None	None		O=C(NCCCn1ccnc1)c1cc2nc(-c3ccccc3)cc(-c3ccccc3)n2n1	10.6019/CHEMBL5058647
	13091356	113511	0	None	-218	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	CHEMBL3321789	113511	0	None	-218	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT2B receptor by liquid scintillation counting	ChEMBL	389	6	1	3	4.8	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCOc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
	118717223	120556	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3343671	120556	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	CHEMBL3545813	120556	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cellsDisplacement of [3H]mesulergine from human 5-HT2B receptor expressed in HEK293 cells	ChEMBL	321	1	2	2	2.2	NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2	10.1016/j.bmc.2014.09.005
	46914485	15400	0	None	83	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	CHEMBL1214961	15400	0	None	83	3	Human	8.0	pKi	=	8.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	336	5	0	4	3.8	COc1ccccc1CN1CCN(Cc2cc3ccccc3o2)CC1	10.1021/jm100639f
	44397731	67188	0	None	-23	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	213	0	1	3	1.3	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)cc3N12	10.1016/j.bmcl.2005.05.074
	CHEMBL187888	67188	0	None	-23	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	213	0	1	3	1.3	C[C@@H]1CNC[C@H]2Cc3ccc(C#N)cc3N12	10.1016/j.bmcl.2005.05.074
	6319	23443	95	None	-	1	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	CHEMBL1333512	23443	95	None	-	1	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	260	4	2	2	5.2	c1ccc(Nc2ccc(Nc3ccccc3)cc2)cc1	nan
	44451369	96305	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2c3c(ccc2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	CHEMBL261489	96305	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cellsDisplacement of [3H]5-HT from human 5HT2B receptor expressed in HEK293-EBNA cells	ChEMBL	187	0	1	2	2.1	c1cc2c3c(ccc2o1)CCNCC3	10.1016/j.bmc.2007.12.009
	135753056	191151	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	CHEMBL5188949	191151	2	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) assessed as displacement of radioligand at 10 uM by radioligand binding assay	ChEMBL	337	4	2	5	2.4	CCc1cc(=O)[nH]c(-n2nc(C)cc2NC(=O)c2cccc(C)c2)n1	10.1021/acs.jmedchem.1c01759
	16062145	97630	0	None	-223	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	269	2	1	3	2.8	Fc1ccc(-c2nc(C3CC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	CHEMBL271111	97630	0	None	-223	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cellsDisplacement of [3H]mesulergine from human recombinant 5HT2B receptor expressed in CHO cells	ChEMBL	269	2	1	3	2.8	Fc1ccc(-c2nc(C3CC3)nc3c2CNCC3)cc1	10.1016/j.bmcl.2008.01.090
	11716185	89035	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2337497	89035	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	CHEMBL2364998	89035	0	None	-20	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysisDisplacement of [3H]-LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by scintillation counting analysis	ChEMBL	250	1	2	2	1.7	CCc1cc(Cl)c2c(c1)[C@H]1CNC[C@@H]1NC2=O	10.1016/j.bmcl.2012.10.091
	10028436	3506	5	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	3237	3506	5	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	CHEMBL95104	3506	5	None	-45	12	Human	7.0	pKi	=	7.0	Binding	Compound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligandCompound was tested for its binding affinity for human cloned 5-hydroxytryptamine 2B receptor in HEK 293 using [3H]ketanserin as a radioligand	ChEMBL	487	7	1	4	4.9	Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2	10.1016/s0960-894x(02)00690-x
	25209705	181036	28	None	-144	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	510	7	2	8	3.3	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1	10.1021/jm800962k
	CHEMBL475965	181036	28	None	-144	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	510	7	2	8	3.3	COc1ccc(-c2ccc(C(=O)Nc3cccc(Cn4ncc(N5CCNCC5)cc4=O)c3C)cc2)cn1	10.1021/jm800962k
	168294400	192456	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC)-c1c(OC)c(OC3CCCCC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	CHEMBL5208882	192456	0	None	1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	423	5	0	5	5.2	COc1cc2c(cc1OC)-c1c(OC)c(OC3CCCCC3)cc3c1[C@H](C2)N(C)CC3	10.1021/acs.jnatprod.2c00365
	118055296	177927	0	None	-58	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	264	2	1	2	2.7	c1ccc(Cc2ccc3c4c2CCN4CCNC3)cc1	10.1016/j.bmcl.2019.126929
	CHEMBL4645736	177927	0	None	-58	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)	ChEMBL	264	2	1	2	2.7	c1ccc(Cc2ccc3c4c2CCN4CCNC3)cc1	10.1016/j.bmcl.2019.126929
	122483281	138083	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3763779	138083	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	CHEMBL3765873	138083	0	None	-18	8	Human	7.0	pKi	=	7.0	Binding	Binding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assayBinding affinity to recombinant 5-HT2B receptor (unknown origin) after 1.5 hrs by radioligand displacement assay	ChEMBL	441	7	0	5	5.4	COc1ccccc1N1CCN(CCCCC(=O)n2c3ccccc3c3ccccc32)CC1	10.1016/j.ejmech.2016.01.043
	136118649	76293	0	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058704	76293	0	None	2	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.0	C/N=C1\NC(=O)/C(=C/c2c[nH]c3ccc(Br)cc23)N1	10.1016/j.bmc.2013.09.011
	11819486	121123	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@H]1C[C@@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	CHEMBL357702	121123	0	None	-4	4	Human	7.0	pKi	=	7.0	Binding	Binding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligandBinding affinity against the cloned human 5-hydroxytryptamine 2B receptor using [3H]5-HT as the radioligand	ChEMBL	172	1	2	1	2.0	N[C@H]1C[C@@H]1c1c[nH]c2ccccc12	10.1021/jm980318q
	58911668	91081	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	CHEMBL2397905	91081	0	None	-3	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysisDisplacement of [125I]LSD from human recombinant 5-HT2B receptor expressed in HEK293E cells after 45 mins by Top counting analysis	ChEMBL	230	1	1	2	1.2	CCc1cccc2c1C[C@@H]1CNCCN1C2=O	10.1016/j.bmcl.2013.04.061
	162652711	180356	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	3	7	2.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CF)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	CHEMBL4751718	180356	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity to 5HT2B (unknown origin)Binding affinity to 5HT2B (unknown origin)	ChEMBL	409	6	3	7	2.6	CC(C)[C@@H](Nc1nc(Cl)nc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(CF)C[C@H]12)C1CC1	10.1016/j.bmcl.2020.127599
	71452341	83668	7	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
	CHEMBL2205361	83668	7	None	-3	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT2B receptor after 1.5 hrs by scintillation counting analysis	ChEMBL	376	6	0	3	5.3	Cc1c(C(=O)N(CCCN2CCCCC2)c2ccccc2)oc2ccccc12	10.1016/j.bmc.2012.09.044
	11848625	5760	0	None	2	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
	CHEMBL1078745	5760	0	None	2	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B receptorBinding affinity to human 5HT2B receptor	ChEMBL	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	10.1016/j.bmcl.2009.09.024
	136118614	93035	0	None	13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	CHEMBL2442276	93035	0	None	13	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	318	1	3	2	2.3	CN1C(=N)N/C(=C/c2c[nH]c3ccc(Br)cc23)C1=O	10.1016/j.bmc.2013.09.011
	10106214	2091	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	1207	2091	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	1209	2091	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	CHEMBL127307	2091	1	None	-46	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	251	2	0	1	3.7	CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1)C	10.1016/j.bmc.2015.01.060
	6604117	187823	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL2062340	187823	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	CHEMBL49623	187823	6	None	1	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assayBinding affinity to 5-HT2B receptor (unknown origin) incubated for 1 hr by radioligand binding assay	ChEMBL	325	5	2	3	3.8	C[C@@H]([C@H](O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1	10.1021/acs.jmedchem.0c01912
	49864027	15385	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	400	8	0	4	4.8	FC(F)CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	CHEMBL1214891	15385	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity to 5HT2BBinding affinity to 5HT2B	ChEMBL	400	8	0	4	4.8	FC(F)CCOc1ccc(CN2CCN(Cc3cc4ccccc4o3)CC2)cc1	10.1021/jm100639f
	168279369	191109	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	CHEMBL5188171	191109	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting methodDisplacement of [3H]LSD from 5-HT2B receptor (unknown origin) assessed as inhibition constant incubated for 90 mins by MicroBeta scintillation counting method	ChEMBL	397	6	0	5	4.6	CCC(C)Oc1cc2c3c(c1OC)-c1cc(OC)c(OC)cc1C[C@@H]3N(C)CC2	10.1021/acs.jnatprod.2c00365
	122186880	122954	0	None	4	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	CHEMBL3608450	122954	0	None	4	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from 5HT2B receptor (unknown origin)Displacement of [3H]LSD from 5HT2B receptor (unknown origin)	ChEMBL	415	3	0	5	4.8	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2c1ccccc1)OCO4	10.1016/j.bmcl.2015.07.012
	44554227	18718	0	None	-33	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	434	4	1	6	4.0	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	CHEMBL1277837	18718	0	None	-33	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	434	4	1	6	4.0	CC(C)n1nc(S(=O)(=O)c2cccc3ccccc23)c2cc(N3CCNCC3)ccc21	10.1021/jm1007825
	20824949	67166	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	245	1	2	3	1.4	CC(=O)Nc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	CHEMBL187787	67166	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]5-HT radioligand	ChEMBL	245	1	2	3	1.4	CC(=O)Nc1ccc2c(c1)N1[C@H](C)CNC[C@H]1C2	10.1016/j.bmcl.2005.05.074
	667590	67765	12	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909048	67765	12	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	313	3	0	1	4.4	O=C(c1ccccc1Cl)N1CCC(Cc2ccccc2)CC1	nan
	44582676	189755	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	CHEMBL516088	189755	0	None	-7	17	Human	6.0	pKi	=	6.0	Binding	Inhibition of human cloned 5HT2B receptor by competitive binding experimentInhibition of human cloned 5HT2B receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
	135511529 135555540	10956	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccccc12	10.1016/j.bmc.2013.09.011
	CHEMBL1173525	10956	0	None	5	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	240	1	3	2	1.5	CN1C(=N)NC(=O)/C1=C\c1c[nH]c2ccccc12	10.1016/j.bmc.2013.09.011
	136118661	76228	0	None	6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058429	76228	0	None	6	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	346	1	1	2	2.7	C/N=C1\N(C)C(=O)/C(=C\c2c[nH]c3c(Br)cccc23)N1C	10.1016/j.bmc.2013.09.011
	44112	121264	48	None	-11	7	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	CHEMBL357995	121264	48	None	-11	7	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	nan
	124247485	164045	8	None	1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	CHEMBL4209274	164045	8	None	1	8	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method	ChEMBL	231	1	2	2	1.9	Fc1ccc(-c2n[nH]c3c2CCNCC3)cc1	10.1021/acs.jmedchem.8b00642
	155563428	175262	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	475	7	3	9	2.7	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	CHEMBL4572905	175262	0	None	-1	5	Human	7.0	pKi	=	7.0	Binding	Inhibition of 5HT2B (unknown origin)Inhibition of 5HT2B (unknown origin)	ChEMBL	475	7	3	9	2.7	CCOC(=O)[C@@]12C[C@@H]1[C@@H](n1cnc3c(NC(C4CCC4)C4CCC4)nc(Cl)nc31)[C@H](O)[C@@H]2O	10.1021/acs.jmedchem.8b01662
	44581974	175680	0	None	-1	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	CHEMBL458220	175680	0	None	-1	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsDisplacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cells	ChEMBL	513	6	2	6	4.6	Cc1c(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cccc1NC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800962k
	25123013	200435	0	None	-27	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	378	3	2	5	2.7	NC1CN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	CHEMBL598443	200435	0	None	-27	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation countingDisplacement of [3H]5HT from human 5HT2B receptor expressed in CHO cells by scintillation counting	ChEMBL	378	3	2	5	2.7	NC1CN(c2ccc3[nH]nc(S(=O)(=O)c4cccc5ccccc45)c3c2)C1	10.1021/jm901674f
	10383646	18730	0	None	-512	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	CHEMBL1277917	18730	0	None	-512	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cellsDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in human HeLa cells	ChEMBL	356	3	1	5	2.1	CN1CCN(c2ccc3[nH]nc(S(=O)(=O)c4ccccc4)c3c2)CC1	10.1021/jm1007825
	71450247	82947	0	None	-19	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	CHEMBL2181188	82947	0	None	-19	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human 5HT2B by Cerep protocol based assayBinding affinity to human 5HT2B by Cerep protocol based assay	ChEMBL	368	5	0	3	5.5	CCCN1CCC(COc2nc3c(Cl)cccc3c3ccccc23)CC1	10.1021/jm300943r
	44404905	72351	1	None	3	3	Human	7.0	pKi	=	7.0	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	4	2	2	2.4	CN(C)CCCc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	CHEMBL198617	72351	1	None	3	3	Human	7.0	pKi	=	7.0	Binding	Inhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSOInhibition constant against human 5-hydroxytryptamine 2B receptor using [3H]LSD as radioligand with the compound (10 uM) dissolved in DMSO	ChEMBL	218	4	2	2	2.4	CN(C)CCCc1c[nH]c2cccc(O)c12	10.1016/j.bmcl.2005.06.104
	17683252	67767	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	CHEMBL1909051	67767	3	None	-	1	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	ChEMBL	347	3	0	1	4.8	O=C(c1ccccc1C(F)(F)F)N1CCC(Cc2ccccc2)CC1	nan
	142601328	184979	0	None	-63	5	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	CHEMBL4854605	184979	0	None	-63	5	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	276	2	2	3	2.5	Clc1ccc(-c2n[nH]cc2N2CCCNCC2)cc1	10.1021/acs.jmedchem.1c01093
	142601341	185348	0	None	-3	3	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	CHEMBL4860503	185348	0	None	-3	3	Human	6.0	pKi	=	6	Binding	Binding affinity to 5HT2B receptor (unknown origin)Binding affinity to 5HT2B receptor (unknown origin)	ChEMBL	272	3	2	4	1.9	COc1cccc(-c2n[nH]cc2N2CCCNCC2)c1	10.1021/acs.jmedchem.1c01093
	56649648	67826	0	None	-301	8	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	CHEMBL1910139	67826	0	None	-301	8	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assayDisplacement of [3H]LSD from 5HT2B receptor expressed in HEK293 EBNA cells by radioligand binding assay	ChEMBL	474	8	0	5	3.0	COc1ccccc1N1CCN(CCN(C(=O)C23C4C5C2C2C3C4C52CF)c2ccccn2)CC1	10.1016/j.ejmech.2011.06.023
	136118616	76219	0	None	3	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	CHEMBL2058415	76219	0	None	3	5	Human	7.0	pKi	=	7	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	332	1	2	2	2.3	C/N=C1\NC(=O)/C(=C\c2c[nH]c3cccc(Br)c23)N1C	10.1016/j.bmc.2013.09.011
	136118646	76290	0	None	2	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	CHEMBL2058701	76290	0	None	2	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cellsDisplacement of [3H]LSD from human recombinant 5HT2B receptor stably expressed in HEK cells	ChEMBL	335	1	2	3	3.1	CSC1=NC(=O)/C(=C/c2c[nH]c3c(Br)cccc23)N1	10.1016/j.bmc.2013.09.011
	3007	155661	27	None	-1	6	Rat	8.3	pKd	=	8.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	Drug Central	135	2	1	1	1.6	CC(N)Cc1ccccc1	None
	CHEMBL405	155661	27	None	-1	6	Rat	8.3	pKd	=	8.3	Binding	Affinity against serotonergic receptor in the isolated rat stomach fundusAffinity against serotonergic receptor in the isolated rat stomach fundus	Drug Central	135	2	1	1	1.6	CC(N)Cc1ccccc1	None
	10615	570	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	46200932	570	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	CHEMBL4297183	570	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	DB14823	570	32	None	501	4	Human	11.6	pKd	=	11.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	3	0	6	4.4	CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1	31951127
	136	3267	32	None	-8	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	223	3267	32	None	-8	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	643606	3267	32	None	-8	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	CHEMBL10347	3267	32	None	-8	16	Human	8.4	pKd	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	134	2497	24	3H- LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2497	24	3H-LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H- LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H- LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H- LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H- LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-LSD	-2	68	Human	10.0	pKi	=	10	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	188	3366	80	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	196968	3366	80	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	CHEMBL473186	3366	80	3H-5HT	-1	6	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	242	469	124	3H-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	242	469	124	[3H]-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	[3H]-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	[3H]-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	[3H]-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	[3H]-LSD	-1	52	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	134	2497	24	3H-5HT	-2	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-2	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-2	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-2	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-2	68	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	5074	3307	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-RAUWOLSCINE	-2	30	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	None	216026	0	3H-5HT	-2	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	None	216026	0	3H-5HT	-2	8	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	107	141	121	3H-5HT	-4	31	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-4	31	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-4	31	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	None	216354	0	3H-MESULERGINE	5	4	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	4106	2485	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-RAUWOLSCINE	-3	34	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	134	2497	24	3H-RAUWOLSCINE	-2	68	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-RAUWOLSCINE	-2	68	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-RAUWOLSCINE	-2	68	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-RAUWOLSCINE	-2	68	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-RAUWOLSCINE	-2	68	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	133	2479	52	3H-MESULERGINE	-2	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-MESULERGINE	-2	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-MESULERGINE	-2	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-MESULERGINE	-2	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-MESULERGINE	-2	43	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	133	2479	52	3H-5HT	-2	43	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-2	43	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-2	43	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-2	43	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-2	43	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	6437377	215929	0	3H-RAUWOLSCINE	5	5	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	5	139	72	3H-5HT	-13	55	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	2470	3626	50	3H-KETANSERIN	-23	60	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-KETANSERIN	-23	60	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-KETANSERIN	-23	60	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-KETANSERIN	-23	60	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-KETANSERIN	-23	60	Bovine	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	None	216026	0	Functional	-2	8	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	1342	36	49	3H-RAUWOLSCINE	2	19	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-RAUWOLSCINE	2	19	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-RAUWOLSCINE	2	19	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	None	216354	0	Functional	5	4	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	1621	2413	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-5HT	-19	45	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5	139	72	Functional	-13	55	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	Functional	-13	55	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	Functional	-13	55	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	Functional	-13	55	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5074	3307	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-2	30	Human	9.0	pKi	=	9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1588	2311	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-5HT	-6	44	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	188	3366	80	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	196968	3366	80	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	CHEMBL473186	3366	80	3H-5HT	-1	6	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	None
	None	216423	0	Functional	1	28	Human	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	5	139	72	3H-5HT	-13	55	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	None	216315	0	3H-MESULERGINE	-1	19	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
	103	4122	61	3H-LSD	1	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	2875	4122	61	3H-LSD	1	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5736	4122	61	3H-LSD	1	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL285802	4122	61	3H-LSD	1	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB09225	4122	61	3H-LSD	1	54	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
	5074	3307	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-MESULERGINE	-2	30	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	189	3466	39	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3466	39	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3466	39	UNDEFINED	2	17	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	11954224	215928	0	3H-5HT	-66	60	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	1588	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1588	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-MESULERGINE	-6	44	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2435	3563	83	3H-LSD	-2	49	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	60149	3563	83	3H-LSD	-2	49	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	98	3563	83	3H-LSD	-2	49	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	CHEMBL12713	3563	83	3H-LSD	-2	49	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	DB06144	3563	83	3H-LSD	-2	49	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
	11957541	1446	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	Functional	-2	16	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	206	2476	16	3H-5HT	-1	25	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-1	25	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-1	25	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	134	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	6437377	215929	0	3H-5HT	5	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	277	1289	62	3H-5HT	-5	46	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	3H-5HT	-5	46	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	3H-5HT	-5	46	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	3H-5HT	-5	46	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	3H-5HT	-5	46	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	4106	2485	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5HT	-3	34	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	135	2515	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-3	58	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	134	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	6437377	215929	0	3H-5HT	5	5	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	5074	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	134	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-2	68	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	5074	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-2	30	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	133	2479	52	3H-5HT	-2	43	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-2	43	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-2	43	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-2	43	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-2	43	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	11954224	215928	0	3H- LSD	-66	60	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	11954224	215928	0	3H-LSD	-66	60	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	206	2476	16	3H-RAUWOLSCINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-RAUWOLSCINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-RAUWOLSCINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	206	2476	16	3H-MESULERGINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-MESULERGINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-MESULERGINE	-1	25	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	199	391	0	3H-5HT	1	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	9821951	391	0	3H-5HT	1	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	CHEMBL160293	391	0	3H-5HT	1	5	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	5	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	135398737	955	93	3H-5HT	-2	92	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-2	92	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-2	92	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-2	92	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-2	92	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	152	363	29	3H-5HT	-1	19	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	363	29	3H-5HT	-1	19	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	363	29	3H-5HT	-1	19	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	152	363	29	3H-5HT	-1	19	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	363	29	3H-5HT	-1	19	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	363	29	3H-5HT	-1	19	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	7153	97992	77	3H-RAUWOLSCINE	-1	34	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-RAUWOLSCINE	-1	34	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	199	391	0	3H-5HT	-5	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	9821951	391	0	3H-5HT	-5	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	CHEMBL160293	391	0	3H-5HT	-5	5	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	11957541	1446	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-KETANSERIN	-16	16	Bovine	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1614	203632	24	Functional	2	10	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	CHEMBL6731	203632	24	Functional	2	10	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	24840389	115187	4	3H-MESULERGINE	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
	CHEMBL334529	115187	4	3H-MESULERGINE	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
	1809	134	32	3H-KETANSERIN	-109647	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-KETANSERIN	-109647	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-KETANSERIN	-109647	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1209	1645	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	3H-5HT	-199	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	1357	2468	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2468	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2468	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2468	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2468	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2468	139	3H-5HT	-3890	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	13139	2474	29	3H-KETANSERIN	-66	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	None
	4076	2474	29	3H-KETANSERIN	-66	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	None
	CHEMBL26687	2474	29	3H-KETANSERIN	-66	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	5	1	4	1.2	COC1=CC(=CC(=C1OC)OC)CCN	None
	107992	2536	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2536	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2536	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2536	49	3H-5HT	-5	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	208	2843	0	3H-5HT	-69	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	4541	2843	0	3H-5HT	-69	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL1494	2843	0	3H-5HT	-69	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	119570	3137	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	119570	3137	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3137	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	2233	3137	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3137	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	953	3137	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3137	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	CHEMBL301265	3137	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3137	96	3H-LSD	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	DB00413	3137	96	3H-MESULERGINE	-7585	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
	243	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3052762	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	3502	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	CHEMBL117287	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	DB06480	3180	91	3H-5HT	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
	2	3237	23	3H-MESULERGINE	-363	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	54562	3237	23	3H-MESULERGINE	-363	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	CHEMBL240773	3237	23	3H-MESULERGINE	-363	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	128563	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	1666	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	CHEMBL445332	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	DB12327	3438	33	3H-LSD	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
	2470	3626	50	3H-5HT	-120226	60	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-120226	60	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-120226	60	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-120226	60	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-120226	60	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2543	3681	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	2543	3681	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	5358	3681	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	54	3681	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL128	3681	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-2818	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB00669	3681	68	3H-5HT	-2818	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	6	2	3	1.3	CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	46882133	5776	0	UNDEFINED	-54	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
	CHEMBL1078896	5776	0	UNDEFINED	-54	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	478	9	2	7	5.1	CCOc1cc(CN2CCC(Nc3nc4cc(NC(=O)C5CCC5)ccc4o3)CC2)ccc1OC	None
	46882180	5809	0	UNDEFINED	-39	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
	CHEMBL1079180	5809	0	UNDEFINED	-39	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	482	7	2	7	3.7	CCOc1cc(CN2CCC(Nc3nc4cc(Cl)c(S(N)(=O)=O)cc4o3)CC2)ccc1F	None
	2662	11352	131	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	CHEMBL118	11352	131	3H-LSD	-41	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
	10836	14435	14	3H-LSD	-3	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	CHEMBL1201201	14435	14	3H-LSD	-3	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	5090	15529	106	3H-LSD	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	CHEMBL122	15529	106	3H-LSD	-1348	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
	5210	33308	48	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
	CHEMBL1200765	33308	48	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
	CHEMBL1419	33308	48	3H-5HT	-123	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	5	0	1	4.7	CC(C)CC(N(C)C)C1(c2ccc(Cl)cc2)CCC1	None
	156391	46770	99	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL1200806	46770	99	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	CHEMBL154	46770	99	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
	4771	50500	29	3H-5HT	1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	1	2.0	CC(C)(N)Cc1ccccc1	None
	CHEMBL1574	50500	29	3H-5HT	1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	1	2.0	CC(C)(N)Cc1ccccc1	None
	2244	94204	100	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	CHEMBL25	94204	100	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
	104870	98852	47	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	5374	98852	47	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	CHEMBL279085	98852	47	3H-MESULERGINE	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
	43815	186896	64	3H-5HT	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL1708	186896	64	3H-5HT	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	CHEMBL490	186896	64	3H-5HT	-1995	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
	3672	192509	136	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	CHEMBL521	192509	136	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
	54676228	193591	112	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	CHEMBL527	193591	112	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
	4495	196512	92	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	CHEMBL56367	196512	92	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
	54677470	200528	115	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL1256873	200528	115	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	CHEMBL599	200528	115	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
	5281600	203002	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	CHEMBL63354	203002	92	3H-LSD	-275	33	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
	5656	203043	87	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	CHEMBL637	203043	87	3H-5HT	-79	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
	3821	204695	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
	CHEMBL742	204695	17	3H-LSD	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
	4158	205318	21	3H-5HT	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL1722	205318	21	3H-5HT	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	CHEMBL796	205318	21	3H-5HT	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
	4054	205478	72	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL1699	205478	72	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	CHEMBL807	205478	72	3H-LSD	-1	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
	6852400	215914	0	3H-KETANSERIN	-25118	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	73759726	215914	0	3H-KETANSERIN	-25118	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
	None	216316	0	3H-MESULERGINE	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
	135269	216363	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
	23681059	216364	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
	5018304	216365	0	3H-LSD	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
	84003	216366	0	3H-LSD	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
	123619	216367	0	3H-LSD	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	119828	216368	0	3H-LSD	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
	None	216369	0	3H-LSD	-7	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
	None	216424	0	3H-5HT	-1	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	4	1	1	4.6	CC(C)CC(C1(CCC1)C2=CC=C(C=C2)Cl)N.Cl	None
	None	216462	0	3H-LSD	-4570	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
	1150	3849	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-2	25	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	185	3975	60	3H-5HT	-2344	38	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3975	60	3H-5HT	-2344	38	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3975	60	3H-5HT	-2344	38	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3975	60	3H-5HT	-2344	38	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	62787	206165	21	3H-5HT	-10	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	CHEMBL8642	206165	21	3H-5HT	-10	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	None	216109	0	3H-LSD	-1122	24	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
	102	4096	48	3H-5HT	-100	50	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-100	50	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-100	50	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-100	50	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-100	50	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	141	1415	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1415	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1415	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1415	35	3H-LSD	-1	22	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	3668	216096	0	3H-LSD	-977	10	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	510	5	4	9	0.4	CNC(=O)C1C(C(C(O1)N2C=NC3=C2N=CN=C3NCC4=CC(=CC=C4)I)O)O	None
	146	135	85	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	164682	135	85	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	CHEMBL275628	135	85	3H-5HT	-1	3	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	1621	2413	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-KETANSERIN	-35	45	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	15897	2840	0	3H-LSD	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-LSD	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-LSD	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2840	0	3H-5-HT	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2840	0	3H-5HT	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-5-HT	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-5HT	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-5-HT	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-5HT	12	37	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	5	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-29	55	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	152	363	29	3H-5HT	1	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	363	29	3H-5HT	1	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	363	29	3H-5HT	1	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	135398745	2893	112	3H-5HT	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-5HT	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-5HT	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-5HT	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	152	363	29	3H-5HT	1	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	363	29	3H-5HT	1	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	363	29	3H-5HT	1	19	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	45486902	196923	0	UNDEFINED	-3	2	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	CHEMBL566396	196923	0	UNDEFINED	-3	2	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	449	5	2	4	4.6	O=c1[nH]c2cccc(OCC3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	1150	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1150	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-8	25	Rat	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	77590	215930	0	3H-5HT	-15	6	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	124	4	0	2	0.8	COCCOCCl	None
	2389	3306	118	35S-GTPGammaS	-66	68	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	35S-GTPGammaS	-66	68	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	35S-GTPGammaS	-66	68	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	35S-GTPGammaS	-66	68	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	35S-GTPGammaS	-66	68	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	542051	206077	6	3H-5HT	-128	7	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	CHEMBL8569	206077	6	3H-5HT	-128	7	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	1809	134	32	3H-5HT	-999	37	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-999	37	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-999	37	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	5	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	199	391	0	3H-5HT	-5	5	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	9821951	391	0	3H-5HT	-5	5	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	CHEMBL160293	391	0	3H-5HT	-5	5	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	None
	135398745	2893	112	35S-GTPGammaS	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	35S-GTPGammaS	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	35S-GTPGammaS	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	35S-GTPGammaS	-5	66	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	135	2515	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-3	58	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	7153	97992	77	3H-MESULERGINE	-1	34	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-MESULERGINE	-1	34	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	134	2497	24	125I-DOI	-10	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	125I-DOI	-10	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	125I-DOI	-10	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	125I-DOI	-10	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	125I-DOI	-10	68	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	None	216423	0	Functional	-1	28	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	216423	0	UNDEFINED	-1	28	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	None	215922	0	3H-KETANSERIN	-851	24	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	2202	3110	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	4850	3110	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	49	3110	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	CHEMBL1371770	3110	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	DB12478	3110	96	3H-MESULERGINE	-6	21	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	221	3465	71	3H-5HT	-4	14	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3465	71	3H-5HT	-4	14	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3465	71	3H-5HT	-4	14	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	5	139	72	125I-DOI	-2951	55	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	125I-DOI	-2951	55	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	125I-DOI	-2951	55	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	125I-DOI	-2951	55	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	1809	134	32	3H-5HT	-999	37	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-999	37	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-999	37	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	173	3238	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	None	216188	0	3H-5HT	-120	15	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	438	5	1	4	4.8	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45	None
	179	399	115	3H-LSD	-17	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-LSD	-17	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-LSD	-17	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-LSD	-17	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-LSD	-17	51	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	77379	19014	75	3H-5HT	-2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	CHEMBL1288716	19014	75	3H-5HT	-2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	102	4096	48	3H-RAUWOLSCINE	-93	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-RAUWOLSCINE	-93	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-RAUWOLSCINE	-93	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-RAUWOLSCINE	-93	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-RAUWOLSCINE	-93	50	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	5	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	77158	19015	56	3H-5HT	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	CHEMBL1288717	19015	56	3H-5HT	2	2	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	None	217442	0	UNDEFINED	-14	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	421	4	3	4	3.3	C1CC2=C(CC1CNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)C6=C(N2)C=CC(=C6)F	None
	145	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	3H-KETANSERIN	-251	30	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1150	3849	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-KETANSERIN	-56	25	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	173	3238	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-5HT	-3	23	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	25058166	215935	0	3H-MESULERGINE	-66	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	6852389	215935	0	3H-MESULERGINE	-66	27	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
	2470	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2470	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-14125	60	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	None	215922	0	3H-5HT	-33	24	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	130	3474	47	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3378093	3474	47	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL281350	3474	47	3H-5HT	-478	13	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	240	941	43	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	941	43	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	941	43	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	941	43	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	941	43	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	941	43	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	941	43	3H-5HT	-26	25	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2105	3032	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-LSD	-28	33	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	138107169	215927	0	3H-5HT	-33	23	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-5HT	-33	23	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	186	1794	52	3H-LSD	-426	17	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1794	52	3H-LSD	-426	17	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1794	52	3H-LSD	-426	17	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	1353	1898	93	3H-5HT	-295	86	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5HT	-295	86	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5HT	-295	86	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5HT	-295	86	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5HT	-295	86	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	None	215915	0	3H-5HT	-2398	21	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	1809	134	32	3H-5HT	-1659	37	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-1659	37	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-1659	37	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	124	2960	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	2032	2960	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	4636	2960	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	CHEMBL762	2960	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	DB00935	2960	47	3H-5HT	-181	33	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	15897	2840	0	3H-LSD	12	37	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-LSD	12	37	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-LSD	12	37	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	138107169	215927	0	3H-5HT	-33	23	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-5HT	-33	23	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	None	215915	0	3H-LSD	-407	21	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	1809	134	32	Functional	-999	37	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	Functional	-999	37	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	Functional	-999	37	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	221	3465	71	UNDEFINED	4	14	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3465	71	UNDEFINED	4	14	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3465	71	UNDEFINED	4	14	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	6446436	216426	0	3H-MESULERGINE	-1	2	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	370	4	3	4	3.2	CC1=CC2=C(C=C1)C(C3=C2N(C=C3)CC(C)N)(C)C.C(=CC(=O)O)C(=O)O	None
	134	2497	24	Functional	-2	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	Functional	-2	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	Functional	-2	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	Functional	-2	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	Functional	-2	68	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1614	203632	24	Functional	2	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	CHEMBL6731	203632	24	Functional	2	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
	1809	134	32	3H-5HT	-1659	37	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-1659	37	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-1659	37	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	107992	2536	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2536	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2536	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2536	49	3H-MESULERGINE	-1	10	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	28	3470	46	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3292447	3470	46	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL20963	3470	46	3H-5HT	-954	10	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	2470	3626	50	3H-5HT	-14125	60	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-14125	60	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-14125	60	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-14125	60	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-14125	60	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2389	3306	118	3H-LSD	-66	68	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-66	68	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-66	68	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-66	68	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-66	68	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	107	141	121	3H-5HT	-4	31	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-4	31	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-4	31	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	None	215922	0	3H-5HT	-12	24	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	None	217444	0	UNDEFINED	-12	3	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	432	3	2	4	3.8	C1CC2=C(CC1CN3CC4CC3CN4C5=CC=CC6=C5OC(=O)N6)C7=C(N2)C=CC(=C7)F	None
	105432	215999	0	3H-5HT	-30	4	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	240	5	1	5	1.5	CC(CC1=CC(=C(C=C1OC)[N+](=O)[O-])OC)N	None
	18971832	2402	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	21	2402	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	CHEMBL3186179	2402	0	3H-5HT	-263	13	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
	37459	743	13	3H-KETANSERIN	-39	25	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	62	743	13	3H-KETANSERIN	-39	25	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	CHEMBL8514	743	13	3H-KETANSERIN	-39	25	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
	None	215922	0	3H-5HT	-12	24	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	5268	3629	40	3H-RAUWOLSCINE	-1047	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3629	40	3H-RAUWOLSCINE	-1047	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3629	40	3H-RAUWOLSCINE	-1047	18	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	173	3238	95	Functional	1	23	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	Functional	1	23	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	Functional	1	23	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1353	1898	93	3H-5HT	-295	86	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5HT	-295	86	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5HT	-295	86	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5HT	-295	86	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5HT	-295	86	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	119607	206180	113	3H-LSD	97	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	CHEMBL865	206180	113	3H-LSD	97	28	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	1809	134	32	3H-5HT	-999	37	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	4	134	32	3H-5HT	-999	37	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL18840	134	32	3H-5HT	-999	37	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	None
	31016	102260	15	3H-5HT	-11	5	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	CHEMBL30336	102260	15	3H-5HT	-11	5	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	213	3824	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	3H-LSD	-5	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5	139	72	3H-5HT	-13	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	134	2497	24	3H-LSD	-2	68	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-LSD	-2	68	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-LSD	-2	68	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-LSD	-2	68	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-LSD	-2	68	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	11957541	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	7153	97992	77	3H-LSD	-1	34	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-LSD	-1	34	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	135	2515	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-3	58	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	3652	4066	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4066	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4066	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4066	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4066	79	3H-5HT	-2	18	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	5268	3629	40	3H-5HT	-616	18	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3629	40	3H-5HT	-616	18	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3629	40	3H-5HT	-616	18	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	1574	81	60	3H-5HT	-2	21	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	60	3H-5HT	-2	21	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	60	3H-5HT	-2	21	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	135	2515	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-37	58	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1150	3849	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	1150	3849	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	125I-DOI	-8	25	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-8	25	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	152	363	29	Functional	1	19	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	363	29	Functional	1	19	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	363	29	Functional	1	19	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	5	139	72	Functional	-13	55	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	Functional	-13	55	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	Functional	-13	55	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	Functional	-13	55	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	4106	2485	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5358812	2485	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	89	2485	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	CHEMBL93240	2485	22	3H-5HT	-3	34	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
	5074	3307	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-2	30	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	None	216026	0	3H-LSD	-2	8	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	339	4	3	3	1.9	CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
	133	2479	52	3H-KETANSERIN	-4	43	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-KETANSERIN	-4	43	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-KETANSERIN	-4	43	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-KETANSERIN	-4	43	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-KETANSERIN	-4	43	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1524	2168	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-KETANSERIN	-1	52	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	None	216354	0	3H-5HT	5	4	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	191	3472	52	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
	443389	3472	52	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
	CHEMBL276140	3472	52	3H-5HT	-1	3	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	None
	None	216353	0	3H-5HT	-2	11	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	243	3	1	4	2.7	CCC1=CC2=C(O1)C=CC3=C2N(N=C3)CC(C)N	None
	135409468	2022	69	3H-LSD	1	40	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	333	2022	69	3H-LSD	1	40	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	CHEMBL845	2022	69	3H-LSD	1	40	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
	5	139	72	3H-MESULERGINE	-13	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-MESULERGINE	-13	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-MESULERGINE	-13	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-MESULERGINE	-13	55	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	155	725	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	725	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	725	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	725	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	725	25	Functional	-5	13	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	1588	2311	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	3H-LSD	-6	44	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	None	216252	0	3H-LSD	-32	12	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	426	6	0	6	3.4	C1CCC2C(C1)C(=O)N(C2=O)CCCCN3CCN(CC3)C4=NSC5=CC=CC=C54	None
	11957541	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	11957541	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-5HT	-2	16	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1615	167767	24	Functional	-2	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167767	24	Functional	-2	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	2389	3306	118	3H-5HT	-549	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-5HT	-549	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-5HT	-549	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-5HT	-549	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-5HT	-549	68	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1524	2168	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	125I-DOI	-154	52	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	189	3466	39	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3466	39	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3466	39	3H-LSD	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	155	725	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	725	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	725	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	725	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	725	25	3H-5HT	-10	13	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	202	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1496	77	3H-5HT	-1	33	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	2477	742	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	3H-5HT	-13	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	1524	2168	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-RAUWOLSCINE	-229	52	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2176	3104	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	3H-5HT	-933	27	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	277	1289	62	125I-DOI	-26	46	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	125I-DOI	-26	46	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	125I-DOI	-26	46	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	125I-DOI	-26	46	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	125I-DOI	-26	46	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	189	3466	39	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3466	39	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3466	39	3H-5HT	-5	17	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	1220	187	55	3H-5HT	-1905	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-1905	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-1905	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-1905	45	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	6917970	3665	61	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	8370	3665	61	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	CHEMBL487387	3665	61	3H-LSD	-51	34	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
	1524	2168	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-MESULERGINE	-229	52	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	104911	215994	0	3H-LSD	-99	38	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
	105432	215999	0	3H-5HT	-44	4	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	240	5	1	5	1.5	CC(CC1=CC(=C(C=C1OC)[N+](=O)[O-])OC)N	None
	1150	3849	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-2	25	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	7153	97992	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	7153	97992	77	UNDEFINED	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	UNDEFINED	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	216423	0	UNDEFINED	-1	28	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	198	312	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	312	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	312	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	312	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	312	126	3H-MESULERGINE	-346	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	None	215922	0	Functional	-33	24	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	11957541	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	7153	97992	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	6166	215998	0	3H-5HT	-7	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
	155	725	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	725	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	725	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	725	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	725	25	3H-5HT	-5	13	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	7153	97992	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	57174031	215917	0	3H-KETANSERIN	-457	20	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
	185	3975	60	3H-LSD	-2344	38	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	5311271	3975	60	3H-LSD	-2344	38	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	CHEMBL74355	3975	60	3H-LSD	-2344	38	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	DB16351	3975	60	3H-LSD	-2344	38	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
	3294	1993	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	71360	1993	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	87	1993	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	CHEMBL14376	1993	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	DB04946	1993	111	3H-LSD	-38	45	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
	3337	206344	27	3H-LSD	-75	41	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-75	41	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-75	41	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-75	41	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-75	41	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	2865	4112	73	3H-5HT	-12	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-5HT	-12	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-5HT	-12	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-5HT	-12	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-5HT	-12	54	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	11957541	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-5HT	-6	16	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	5	139	72	3H-5HT	-29	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-29	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-29	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-29	55	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	11957541	1446	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-5HT	-2	16	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	7153	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	7153	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	138107169	215927	0	3H-5HT	-33	23	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-5HT	-33	23	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	1574	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	1574	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	60	3H-5HT	-3	21	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	115	3762	80	Functional	-1	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3762	80	Functional	-1	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3762	80	Functional	-1	27	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	2389	3306	118	3H-5HT	-66	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-5HT	-66	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-5HT	-66	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-5HT	-66	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-5HT	-66	68	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1150	3849	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	Functional	-2	25	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	107992	2536	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2536	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2536	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2536	49	Functional	-1	10	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	11954224	215928	0	3H-5HT	-66	60	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	None	216423	0	3H-MESULERGINE	1	28	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	7153	97992	77	3H-5HT	-1	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	1342	36	49	3H-5HT	2	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	2	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	2	19	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	206	2476	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	135398737	955	93	3H-RAUWOLSCINE	-2	92	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-RAUWOLSCINE	-2	92	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-RAUWOLSCINE	-2	92	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-RAUWOLSCINE	-2	92	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-RAUWOLSCINE	-2	92	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	206	2476	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-1	25	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	242	469	124	3H-LSD	-1	52	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	3H-LSD	-1	52	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	3H-LSD	-1	52	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	3H-LSD	-1	52	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	3H-LSD	-1	52	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	11954224	215928	0	3H-5HT	-66	60	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	206	2476	16	3H-5HT	-1	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-1	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-1	25	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	5074	3307	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	125I-DOI	-6	30	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1342	36	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1621	2413	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-LSD	-19	45	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	1342	36	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	2	19	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1621	2413	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	3H-LSD	-39	45	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	None	215915	0	Functional	-407	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	6971132	215984	0	3H-LSD	-7	14	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	268	1	2	2	2.1	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)O	None
	219050	3348	25	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	52	3348	25	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	CHEMBL431367	3348	25	3H-MESULERGINE	-194	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
	2470	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2	3237	23	3H-5HT	-363	29	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	54562	3237	23	3H-5HT	-363	29	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	CHEMBL240773	3237	23	3H-5HT	-363	29	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
	186	1794	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1794	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1794	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	31016	102260	15	3H-5HT	-5	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	CHEMBL30336	102260	15	3H-5HT	-5	5	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	225	5	1	4	1.6	COc1cc(CC(C)N)cc(OC)c1OC	None
	135398737	955	93	3H-5HT	-36	92	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-36	92	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-36	92	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-36	92	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-36	92	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	102	4096	48	3H-5HT	-93	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-93	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-93	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-93	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-93	50	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	7153	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	215922	0	3H-5HT	-33	24	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	346	5	4	4	2.5	COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O	None
	6166	215998	0	3H-5HT	-4	4	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
	1574	81	60	3H-5HT	-3	21	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	60	3H-5HT	-3	21	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	60	3H-5HT	-3	21	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	130	3474	47	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	3378093	3474	47	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL281350	3474	47	35S-GTPGammaS	-478	13	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	2470	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1524	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2470	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	2470	3626	50	3H-RAUWOLSCINE	-14125	60	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-RAUWOLSCINE	-14125	60	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-RAUWOLSCINE	-14125	60	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-RAUWOLSCINE	-14125	60	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-RAUWOLSCINE	-14125	60	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	7153	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	1524	2168	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-229	52	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2470	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	15760	113052	57	3H-5HT	-5	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	None
	CHEMBL331241	113052	57	3H-5HT	-5	2	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	174	2	2	1	2.0	Cc1ccc2[nH]cc(CCN)c2c1	None
	None	215915	0	3H-LSD	-407	21	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
	186	1794	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1794	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1794	52	3H-5HT	-426	17	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	2470	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-120226	60	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	138107169	215927	0	3H-5HT	-117	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-5HT	-117	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	138107169	215927	0	3H-5HT	-117	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-5HT	-117	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	206	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	1524	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-2691	52	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	206	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	7153	97992	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	1353	1898	93	3H-5HT	-295	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	3H-5HT	-295	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	3H-5HT	-295	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	3H-5HT	-295	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	3H-5HT	-295	86	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	1524	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2168	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-KETANSERIN	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	2220	3112	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	27400	3112	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	93	3112	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	CHEMBL294951	3112	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	DB06153	3112	82	3H-5HT	-10	14	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	77158	19015	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	CHEMBL1288717	19015	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	2402	3345	62	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3345	62	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3345	62	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3345	62	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3345	62	3H-MESULERGINE	-9	25	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	145	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	1832	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	CHEMBL7257	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	DB14010	140	49	3H-LSD	-87	30	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	None
	77158	19015	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	CHEMBL1288717	19015	56	3H-5HT	-2	2	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	238	2	2	1	2.4	NCCc1c[nH]c2ccc(Br)cc12	None
	206	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-5HT	-26	25	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	138107169	215927	0	3H-5HT	-117	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-5HT	-117	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	115	3762	80	3H-5HT	-1	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3762	80	3H-5HT	-1	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3762	80	3H-5HT	-1	27	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	3337	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	1524	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-229	52	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	102	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	102	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-93	50	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	1524	2168	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-2691	52	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	5	139	72	3H-5HT	-13	55	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	135398737	955	93	3H-LSD	-2	92	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-LSD	-2	92	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-LSD	-2	92	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-LSD	-2	92	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-LSD	-2	92	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	138107169	215927	0	3H-RAUWOLSCINE	-33	23	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-RAUWOLSCINE	-33	23	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	135	2515	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-3	58	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2865	4112	73	3H-LSD	-12	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	3H-LSD	-12	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	3H-LSD	-12	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	3H-LSD	-12	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	3H-LSD	-12	54	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	1342	36	49	3H-5HT	-4	19	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	-4	19	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	-4	19	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3117	207818	103	None	-8	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	CHEMBL964	207818	103	None	-8	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
	104903	56314	17	None	-4	6	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	None
	CHEMBL1630578	56314	17	None	-4	6	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	None
	7153	97992	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	102	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	7153	97992	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-5HT	-1	34	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	164	1448	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	85875	1448	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	CHEMBL8600	1448	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	DB01528	1448	19	3H-KETANSERIN	-17	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	209	4	1	3	1.9	COc1cc(C)c(cc1CC(N)C)OC	None
	3337	206344	27	Functional	-75	41	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	Functional	-75	41	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	Functional	-75	41	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	Functional	-75	41	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	Functional	-75	41	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	None	217441	0	UNDEFINED	-83	3	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	449	6	3	4	4.1	C1CC2=C(CC1CCCNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)NC6=C2C=C(C=C6)F	None
	107992	2536	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2536	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2536	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2536	49	3H-5HT	-5	10	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	1220	187	55	3H-5HT	-1905	45	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-1905	45	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-1905	45	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-1905	45	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	11848624	89117	0	UNDEFINED	2	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
	CHEMBL236587	89117	0	UNDEFINED	2	6	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	381	7	1	6	4.3	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1OC	None
	2389	3306	118	3H-LSD	-66	68	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	3H-LSD	-66	68	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	3H-LSD	-66	68	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	3H-LSD	-66	68	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	3H-LSD	-66	68	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	1220	187	55	3H-5HT	-3235	45	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-5HT	-3235	45	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-5HT	-3235	45	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-5HT	-3235	45	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	3337	206344	27	3H-5HT	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	3337	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-5HT	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-5HT	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-5HT	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-5HT	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-75	41	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	1210	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	915	51	3H-RAUWOLSCINE	-1380	21	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	102	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	155	725	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	163	725	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	62065	725	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	CHEMBL6607	725	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	DB01484	725	25	3H-5HT	-5	13	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	None
	102	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-93	50	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	11954224	215928	0	3H-LSD	-66	60	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	11291	3196	26	3H-KETANSERIN	-44	5	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
	4980	3196	26	3H-KETANSERIN	-44	5	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
	CHEMBL65547	3196	26	3H-KETANSERIN	-44	5	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	204	3	2	2	2.0	CN(CCc1c[nH]c2c1c(O)ccc2)C	None
	None	216423	0	3H-5HT	1	28	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	173	3238	95	3H-KETANSERIN	-5	23	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-KETANSERIN	-5	23	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-KETANSERIN	-5	23	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	2181	3106	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3106	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3106	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3106	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3106	46	3H-5HT	-15	35	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	15897	2840	0	3H-5-HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2840	0	3H-5HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-5-HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-5HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-5-HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-5HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	186	1794	52	3H-5HT	-776	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	71781	1794	52	3H-5HT	-776	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	CHEMBL18972	1794	52	3H-5HT	-776	17	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
	5268	3629	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3629	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3629	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	15897	2840	0	3H-LSD	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-LSD	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-LSD	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	173	3238	95	3H-5HT	1	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-5HT	1	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-5HT	1	23	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	11653679	181167	1	UNDEFINED	-75	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
	CHEMBL476108	181167	1	UNDEFINED	-75	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
	10836	14435	14	None	-3	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	CHEMBL1201201	14435	14	None	-3	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
	5475158	67183	25	3H-KETANSERIN	-1	14	Bovine	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
	CHEMBL18786	67183	25	3H-KETANSERIN	-1	14	Bovine	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
	5074	3307	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5074	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-2	30	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	5870	31630	92	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	None
	CHEMBL1405	31630	92	None	-	1	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	270	0	1	2	3.8	C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CCC2=O	None
	None	216354	0	3H-5HT	5	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	5074	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	2812	4747	101	None	-40	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	CHEMBL104	4747	101	None	-40	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
	222757	99348	73	None	-1	3	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	None
	CHEMBL282575	99348	73	None	-1	3	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	376	2	1	3	5.1	C[C@]12CC[C@@H]3c4ccc(OC(=O)c5ccccc5)cc4CC[C@H]3[C@@H]1CC[C@@H]2O	None
	1210	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	915	51	None	-1380	21	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	5074	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-8	30	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	1357	2468	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2468	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2468	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2468	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2468	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2468	139	None	-3890	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1342	36	49	3H-5HT	-4	19	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	-4	19	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	-4	19	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	1209	1645	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	None	-199	32	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3198	205490	76	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1201049	205490	76	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL808	205490	76	None	-30	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	2406	100376	89	None	-27	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
	CHEMBL290106	100376	89	None	-27	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
	None	216354	0	3H-5HT	5	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	342	4	3	4	2.5	CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O	None
	66265	93984	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL248702	93984	15	None	-1	19	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCN[C@@H](C)Cc1cccc(C(F)(F)F)c1	None
	1836	2574	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	3340	2574	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	5281040	2574	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	CHEMBL787	2574	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	DB00471	2574	59	None	-69	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
	2402	3345	62	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	5095	3345	62	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	7295	3345	62	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	CHEMBL589	3345	62	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	DB00268	3345	62	None	-9	25	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
	3598	187797	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
	CHEMBL496	187797	76	None	-2	7	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
	135	2515	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-RAUWOLSCINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4189	206899	96	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1559	206899	96	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL91	206899	96	None	-26	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	4943	193393	105	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	None
	CHEMBL526	193393	105	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	178	2	1	1	3.6	CC(C)c1cccc(C(C)C)c1O	None
	3336	94972	30	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
	CHEMBL1405922	94972	30	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
	CHEMBL254832	94972	30	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	None
	135	2515	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-MESULERGINE	-3	58	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	189	3466	39	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	5163	3466	39	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	CHEMBL297784	3466	39	3H-MESULERGINE	-5	17	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	None
	4211	57792	83	None	-2	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
	CHEMBL1670	57792	83	None	-2	4	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	318	3	0	0	5.9	Clc1ccc(C(c2ccccc2Cl)C(Cl)Cl)cc1	None
	5353853	17954	47	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	9556529	17954	47	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	CHEMBL1262	17954	47	None	-23	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
	1599	2326	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	3955	2326	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	7215	2326	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	CHEMBL841	2326	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	DB00836	2326	50	None	-144	16	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	None
	4209	3141	75	None	-758	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	4893	3141	75	None	-758	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	503	3141	75	None	-758	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	5385	3141	75	None	-758	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	CHEMBL2	3141	75	None	-758	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	DB00457	3141	75	None	-758	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	2142	3074	58	None	-43	37	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	4920903	3074	58	None	-43	37	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	502	3074	58	None	-43	37	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	5775	3074	58	None	-43	37	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	CHEMBL597	3074	58	None	-43	37	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	DB00692	3074	58	None	-43	37	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
	146	135	85	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	164682	135	85	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	CHEMBL275628	135	85	3H-5HT	1	3	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	178	2	2	1	1.8	NCCc1c[nH]c2c1cc(F)cc2	None
	68617	205504	62	None	-15	26	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL1709	205504	62	None	-15	26	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	CHEMBL809	205504	62	None	-15	26	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
	4601	206724	35	None	-4	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL1201023	206724	35	None	-4	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	CHEMBL900	206724	35	None	-4	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	None
	448537	160226	89	None	-21	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
	CHEMBL411	160226	89	None	-21	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
	2176	3104	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	4828	3104	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	91	3104	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	CHEMBL500	3104	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	DB00960	3104	68	None	-933	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	None
	1531	2253	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	3869	2253	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	7207	2253	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	CHEMBL429	2253	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	DB00598	2253	69	None	-16	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	328	8	5	4	2.9	CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=N)O)O)O	None
	5318	15544	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1200348	15544	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	CHEMBL1221	15544	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
	119607	206180	113	None	97	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	CHEMBL865	206180	113	None	97	28	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
	1227	2472	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	2331	2472	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	3957	2472	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	4992	2472	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	CHEMBL511	2472	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	DB06691	2472	43	None	-112	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	None
	3151	1450	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	945	1450	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	965	1450	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	CHEMBL219916	1450	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	DB01184	1450	97	None	-125	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
	1343	1876	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	3519	1876	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	522	1876	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	CHEMBL862	1876	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	DB01018	1876	62	None	-14	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	245	2	2	1	1.3	O=C(Cc1c(Cl)cccc1Cl)N=C(N)N	None
	1016	3720	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2561	3720	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	2733526	3720	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5384	3720	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	CHEMBL83	3720	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	DB00675	3720	78	None	-17	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
	5510	205829	100	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	None
	CHEMBL83668	205829	100	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	2	0	2	4.9	Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1	None
	2202	3110	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	4850	3110	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	49	3110	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	CHEMBL1371770	3110	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	DB12478	3110	96	None	-6	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
	2723	154022	108	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	None
	CHEMBL398440	154022	108	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	156	0	1	1	2.7	Cc1cc(O)cc(C)c1Cl	None
	2771	194994	74	None	1	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL1200781	194994	74	None	1	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	CHEMBL549	194994	74	None	1	27	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
	2333	142310	97	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	None
	CHEMBL388590	142310	97	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	422	3	1	3	5.5	CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1	None
	135	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2470	3626	50	125I-DOI	-1513	60	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	125I-DOI	-1513	60	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	125I-DOI	-1513	60	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	125I-DOI	-1513	60	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	125I-DOI	-1513	60	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	102	4096	48	3H-5HT	-93	50	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	102	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-93	50	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-93	50	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-93	50	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-93	50	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	135	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	221	3465	71	UNDEFINED	4	14	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3465	71	UNDEFINED	4	14	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3465	71	UNDEFINED	4	14	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	102	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	1615	167767	24	3H-LSD	-2	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167767	24	3H-LSD	-2	45	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	122	1425	9	3H-5HT	-100	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	156314	1425	9	3H-5HT	-100	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	CHEMBL1332062	1425	9	3H-5HT	-100	11	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	287	8	2	2	2.9	CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N	None
	1209	1645	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	203	1645	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3386	1645	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL41	1645	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	DB00472	1645	75	3H-5HT	-199	32	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	5268	3629	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	53	3629	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	CHEMBL300555	3629	40	3H-5HT	-1047	18	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	None
	208	2843	0	3H-5HT	-69	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	4541	2843	0	3H-5HT	-69	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	CHEMBL1494	2843	0	3H-5HT	-69	13	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
	3337	206344	27	3H-5-HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	3337	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-5-HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-5-HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-5-HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-5-HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	221	3465	71	3H-MESULERGINE	-4	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3465	71	3H-MESULERGINE	-4	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3465	71	3H-MESULERGINE	-4	14	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3337	206344	27	3H-LSD	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	108182	4100	22	3H-5HT	-1	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	245	4100	22	3H-5HT	-1	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	CHEMBL18041	4100	22	3H-5HT	-1	17	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	309	3	2	4	1.8	COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl	None
	15897	2840	0	3H-LSD	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-LSD	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-LSD	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	15897	2840	0	3H-5HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	3H-5HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	3H-5HT	12	37	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	135	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	135	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-37	58	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	None	216000	0	3H-5HT	-5	4	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
	2105	3032	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	Functional	-28	33	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	102	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	135398745	2893	112	3H-5HT	-27	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-5HT	-27	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-5HT	-27	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-5HT	-27	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	11957541	1446	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-5HT	-2	16	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	102	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	3H-5HT	-100	50	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	542051	206077	6	3H-5HT	-61	7	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	CHEMBL8569	206077	6	3H-5HT	-61	7	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	237	6	1	3	2.5	CCCc1cc(OC)c(CC(C)N)cc1OC	None
	1220	187	55	3H-KETANSERIN	-4265	45	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	3H-KETANSERIN	-4265	45	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	3H-KETANSERIN	-4265	45	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	3H-KETANSERIN	-4265	45	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	3337	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-5HT	-75	41	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	11957541	1446	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-KETANSERIN	-16	16	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	141	1415	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	6089	1415	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	CHEMBL12420	1415	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	DB01488	1415	35	3H-KETANSERIN	-6	22	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	188	3	1	1	2.3	CN(CCc1c[nH]c2c1cccc2)C	None
	31101	726	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	3H-MESULERGINE	-26	36	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	2181	3106	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3106	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3106	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3106	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3106	46	3H-5HT	-478	35	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	3337	206344	27	3H-5-HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	3337	206344	27	3H-5HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	3337	206344	27	3H-LSD	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-5-HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-5HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-5-HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-5HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-5-HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-5HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-5-HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-5HT	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-75	41	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	1357	2468	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2468	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2468	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2468	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2468	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2468	139	3H-MESULERGINE	-3890	9	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	115	3762	80	3H-5HT	-1	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3762	80	3H-5HT	-1	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3762	80	3H-5HT	-1	27	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	138107169	215927	0	3H-5HT	-117	23	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	22831402	215927	0	3H-5HT	-117	23	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O	None
	2470	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	283	3108	57	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3108	57	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3108	57	3H-5HT	-562	12	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	2726	916	68	3H-KETANSERIN	-3	73	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	3H-KETANSERIN	-3	73	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	3H-KETANSERIN	-3	73	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	3H-KETANSERIN	-3	73	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	3H-KETANSERIN	-3	73	Bovine	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	None	217442	0	UNDEFINED	-14	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	421	4	3	4	3.3	C1CC2=C(CC1CNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)C6=C(N2)C=CC(=C6)F	None
	44112	121264	48	None	-11	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	None
	CHEMBL357995	121264	48	None	-11	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	380	7	2	4	4.5	Cc1cc2c(OCC(CNC(C)(C)C)OC(=O)c3ccccc3)cccc2[nH]1	None
	1548955	88552	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	2800	88552	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	CHEMBL2355051	88552	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
	3168	9230	92	None	-107	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	CHEMBL1108	9230	92	None	-107	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
	3042	1402	35	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	355	1402	35	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	868	1402	35	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	CHEMBL1123	1402	35	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	DB00804	1402	35	None	-39	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	None
	5591	157507	90	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	None
	CHEMBL408	157507	90	None	1	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	None
	1353	1898	93	None	-295	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	3559	1898	93	None	-295	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	86	1898	93	None	-295	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	CHEMBL54	1898	93	None	-295	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	DB00502	1898	93	None	-295	86	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
	4452	2742	19	3H-LSD	-208	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	983	2742	19	3H-LSD	-208	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	CHEMBL20734	2742	19	3H-LSD	-208	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
	4178	195780	63	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	None
	CHEMBL558	195780	63	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	179	3	1	2	2.0	Cc1cccc(C)c1OCC(C)N	None
	1224	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	3100	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	8980	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	916	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	CHEMBL657	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	DB01075	1420	83	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	255	6	0	2	3.4	CN(CCOC(c1ccccc1)c1ccccc1)C	None
	146159245	188426	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	451415	188426	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	86289437	188426	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	CHEMBL502620	188426	30	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	811	9	4	16	3.2	CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC	None
	12488	1644	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	941361	1644	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	CHEMBL30008	1644	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	DB04841	1644	56	None	-11	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
	3033538	1307	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	7155	1307	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	781	1307	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	CHEMBL1201216	1307	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	DB00298	1307	39	None	-12	9	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	4	0	5	2.3	Cc1ccccc1N1CCN(CC1)CCc1nnc2n1CCCC2	None
	77379	19014	75	3H-5HT	2	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	CHEMBL1288716	19014	75	3H-5HT	2	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	194	2	2	1	2.3	NCCc1c[nH]c2ccc(Cl)cc12	None
	657255	199061	34	None	-9	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
	CHEMBL588119	199061	34	None	-9	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
	176	397	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2157	397	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	2566	397	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	CHEMBL633	397	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	DB01118	397	66	None	-1	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
	4098	32475	30	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1255739	32475	30	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	CHEMBL1411979	32475	30	None	-14	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	None
	5282379	194961	69	None	1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	None
	CHEMBL547	194961	69	None	1	3	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1	None
	134	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	2028	2958	80	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	359	2958	80	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	4634	2958	80	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	CHEMBL1231	2958	80	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	DB01062	2958	80	None	-40	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	357	7	1	4	3.3	CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC	None
	134	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	134	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-12	68	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	6437377	215929	0	3H-5HT	-5	5	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	1547484	937	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	654	937	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	9072	937	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	CHEMBL43064	937	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	DB00568	937	74	None	-8	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	4595	176691	106	None	2	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL46	176691	106	None	2	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
	1782	2501	84	None	-3	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	241	2501	84	None	-3	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	4168	2501	84	None	-3	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	CHEMBL86	2501	84	None	-3	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	DB01233	2501	84	None	-3	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
	2477	742	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	36	742	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	437	742	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	CHEMBL49	742	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	DB00490	742	59	None	-13	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
	5074	3307	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	97	3307	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	CHEMBL267777	3307	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	DB12693	3307	80	3H-5HT	-2	30	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
	6075	150084	42	None	-8	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	CHEMBL395110	150084	42	None	-8	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	None
	2470	3626	50	None	-14125	60	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	None	-14125	60	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	None	-14125	60	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	None	-14125	60	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	None	-14125	60	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	198	312	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	312	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	312	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	312	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	312	126	None	-346	6	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	210	3451	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	2423	3451	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	5160	3451	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	CHEMBL52939	3451	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	DB12163	3451	0	None	-7	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	None
	133	2479	52	3H-5HT	-12	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	3H-5HT	-12	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	3H-5HT	-12	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	3H-5HT	-12	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	3H-5HT	-12	43	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	6726	1269	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	7151	1269	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	749	1269	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	CHEMBL648	1269	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	DB01176	1269	51	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	None
	3157	1458	71	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	7170	1458	71	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	954	1458	71	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	CHEMBL707	1458	71	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	DB00590	1458	71	None	-37	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	None
	444795	139974	105	None	3	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	None
	CHEMBL38	139974	105	None	3	2	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	300	5	1	1	5.6	CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)C(C)(C)CCC1	None
	2284	3160	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	4926	3160	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	7281	3160	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	CHEMBL564	3160	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	DB00420	3160	33	None	-16	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
	165193	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	2303	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	4946	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	564	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	62882	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	63	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	66366	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	91536	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL27	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	CHEMBL452861	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	DB00571	3165	68	None	-72	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	259	6	2	3	2.6	OC(COc1cccc2c1cccc2)CNC(C)C	None
	4011	82379	49	None	-20	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	CHEMBL21731	82379	49	None	-20	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
	3191	102831	97	None	-7	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	CHEMBL305660	102831	97	None	-7	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
	1524	2168	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	None	-229	52	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	119584	2577	102	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	1848	2577	102	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	242	2577	102	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	CHEMBL60889	2577	102	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	DB11675	2577	102	None	1	6	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	421	7	2	5	3.1	CCOc1cc(N)c(cc1C(=O)NCC1OCCN(C1)Cc1ccc(cc1)F)Cl	None
	33630	178933	99	None	-6	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	CHEMBL47050	178933	99	None	-6	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assayDisplacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
	1605	2327	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	3957	2327	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	7216	2327	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	CHEMBL998	2327	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	DB00455	2327	117	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	382	1	0	3	4.9	CCOC(=O)N1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1	None
	2895	203569	41	None	1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	CHEMBL669	203569	41	None	1	8	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	275	3	0	1	4.6	CN(C)CCC=C1c2ccccc2C=Cc2ccccc21	None
	2398	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	2801	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	701	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	CHEMBL415	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	DB01242	951	62	None	-3	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
	1222	1651	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3396	1651	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	85	1651	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL46516	1651	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	DB04842	1651	49	None	-52	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	11658860	2329	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	2941	2329	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	4374	2329	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	CHEMBL360328	2329	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	DB04871	2329	51	None	-1	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	None
	124	2960	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	2032	2960	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	4636	2960	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	CHEMBL762	2960	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	DB00935	2960	47	None	-181	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	260	2	2	3	2.9	Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C	None
	6437377	215929	0	3H-5HT	-5	5	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	500	6	3	7	3.2	CC(C)N1C=C2CC3C(CC(CN3C)C(=O)OC(C)C(C)O)C4=C2C1=CC=C4.C(=CC(=O)O)C(=O)O	None
	1201549	594	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	333	594	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	7601	594	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL1201203	594	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	CHEMBL438151	594	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	DB00245	594	24	None	-26	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	None
	228	444	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	33	444	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	6005	444	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	CHEMBL53	444	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	DB00714	444	28	None	-5	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
	152	363	29	3H-5HT	1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2107	363	29	3H-5HT	1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	CHEMBL275854	363	29	3H-5HT	1	19	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	None
	2520	203985	70	None	-4	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL1280	203985	70	None	-4	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	CHEMBL6966	203985	70	None	-4	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	None
	15897	2840	0	Functional	12	37	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	215	2840	0	Functional	12	37	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	CHEMBL1979333	2840	0	Functional	12	37	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
	None	215916	0	3H-KETANSERIN	-19	6	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	6	2	7	2.1	CC(C1=CC=CC2=NC3=C(C=CC=C3N=C21)C(=O)O)OC(=O)C(CO)OC	None
	10624	70271	19	3H-KETANSERIN	-46	33	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	70271	19	3H-KETANSERIN	-46	33	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	70271	19	3H-KETANSERIN	-46	33	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	71285	215960	0	Functional	1	2	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	209	3	2	4	1.3	CC(CC1=CC2=C(C=C1O)OCO2)NC	None
	283	3108	57	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	4847	3108	57	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	CHEMBL18331	3108	57	3H-5HT	-57	12	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	393	5	0	5	3.3	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2	None
	115237	55555	119	3H-LSD	-89	55	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	3H-LSD	-89	55	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	None	217441	0	UNDEFINED	-83	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	449	6	3	4	4.1	C1CC2=C(CC1CCCNCC3COC4=C(O3)C=CC5=C4CC(=O)N5)NC6=C2C=C(C=C6)F	None
	107992	2536	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	165	2536	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	CHEMBL269521	2536	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	DB12111	2536	49	3H-5HT	-1	10	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	None
	240	941	43	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	941	43	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	941	43	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	941	43	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	941	43	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	941	43	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	941	43	3H-5HT	-6	25	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	7153	97992	77	Functional	-1	34	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	Functional	-1	34	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	216423	0	Functional	1	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	107780	1831	54	3H-5HT	-676	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	14	1831	54	3H-5HT	-676	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	CHEMBL15928	1831	54	3H-5HT	-676	18	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	None
	1524	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	1524	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-229	52	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	173	3238	95	3H-5HT	-3	23	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-5HT	-3	23	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-5HT	-3	23	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1574	81	60	125I-DOI	-70	21	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	218	81	60	125I-DOI	-70	21	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	CHEMBL266591	81	60	125I-DOI	-70	21	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
	173	3238	95	125I-DOI	-75	23	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	125I-DOI	-75	23	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	125I-DOI	-75	23	Mouse	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	1342	36	49	3H-5HT	-4	19	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	3	36	49	3H-5HT	-4	19	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	CHEMBL277120	36	49	3H-5HT	-4	19	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	None
	44626329	197385	0	UNDEFINED	-20	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	CHEMBL569513	197385	0	UNDEFINED	-20	3	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	420	3	2	4	3.7	O=c1[nH]c2cccc(N3CCN(CC4CCc5[nH]c6ccc(F)cc6c5C4)CC3)c2o1	None
	3337	206344	27	3H-LSD	-75	41	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	3H-LSD	-75	41	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	3H-LSD	-75	41	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	3H-LSD	-75	41	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	3H-LSD	-75	41	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	1210	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	915	51	3H-5HT	-1380	21	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	62787	206165	21	3H-KETANSERIN	-67	10	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	CHEMBL8642	206165	21	3H-KETANSERIN	-67	10	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	2470	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5440	28693	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
	CHEMBL1378	28693	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
	4976	203556	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	CHEMBL668	203556	29	None	-1	12	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	263	4	1	1	4.3	CNCCCC1c2ccccc2C=Cc2ccccc21	None
	5022	1638	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	6918248	1638	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	8182	1638	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	CHEMBL231068	1638	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	DB04908	1638	76	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	None
	1971	2846	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	2404	2846	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	4543	2846	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	CHEMBL445	2846	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	DB00540	2846	38	None	-4	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
	107	141	121	3H-5HT	-12	31	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-12	31	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-12	31	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	213	3824	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	None	-5	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	11957541	1446	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	1229	1446	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	147	1446	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	170617	1446	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	CHEMBL6616	1446	40	3H-MESULERGINE	-2	16	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	None
	2105	3032	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	47811	3032	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	48	3032	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	CHEMBL531	3032	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	DB01186	3032	37	3H-MESULERGINE	-28	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
	2601	3751	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3751	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3751	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3751	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3751	33	3H-MESULERGINE	-8	21	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	100	3776	58	None	-11	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	3776	58	None	-11	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	3776	58	None	-11	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	3776	58	None	-11	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	3776	58	None	-11	56	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	240	941	43	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	2769	941	43	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	44279790	941	43	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	660	941	43	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL1729	941	43	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	CHEMBL560739	941	43	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	DB00604	941	43	None	-6	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
	135398737	955	93	3H-5HT	-2	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-2	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-2	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-2	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-2	92	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	2351	3261	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	2820	3261	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	5035	3261	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	CHEMBL81	3261	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	DB00481	3261	64	None	-7	21	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
	2274	3151	58	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	4917	3151	58	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	7279	3151	58	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	CHEMBL728	3151	58	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	DB00433	3151	58	None	-10	32	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
	2099	9275	55	None	-	1	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	None
	CHEMBL1110	9275	55	None	-	1	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	294	2	1	3	2.4	Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O	None
	135398745	2893	112	3H-LSD	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	3H-LSD	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	3H-LSD	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	3H-LSD	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	3952	1875	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	5353646	1875	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	5443	1875	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	5702063	1875	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	CHEMBL1331786	1875	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	CHEMBL420	1875	38	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	None
	115237	55555	119	None	-89	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	CHEMBL1621	55555	119	None	-89	55	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
	2291	3162	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	2561	3162	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	4932	3162	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	CHEMBL631	3162	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	DB01182	3162	58	None	-3	12	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	341	11	2	4	3.2	CCCNCC(COc1ccccc1C(=O)CCc1ccccc1)O	None
	216239	23763	118	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1200485	23763	118	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	CHEMBL1336	23763	118	None	2	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counterDisplacement of [3H]LSD from 5HT2B receptor after 1.5 hrs by scintillation counter	Drug Central	464	5	3	4	5.6	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1	None
	2726	916	68	None	-19	73	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	621	916	68	None	-19	73	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	83	916	68	None	-19	73	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	CHEMBL71	916	68	None	-19	73	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	DB00477	916	68	None	-19	73	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
	31101	726	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	35	726	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	403	726	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	CHEMBL493	726	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	DB01200	726	40	None	-26	36	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
	102	4096	48	None	-100	50	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	None	-100	50	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	None	-100	50	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	None	-100	50	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	None	-100	50	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	2181	3106	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	4830	3106	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	92	3106	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	CHEMBL440294	3106	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	DB09286	3106	46	None	-15	35	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
	2286	3161	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	4927	3161	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	7282	3161	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	CHEMBL643	3161	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	DB01069	3161	51	None	-5	30	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
	180	400	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	200	400	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2160	400	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	CHEMBL629	400	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	DB00321	400	56	None	-35	40	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
	2389	3306	118	None	-66	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	5073	3306	118	None	-66	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	96	3306	118	None	-66	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	CHEMBL85	3306	118	None	-66	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	DB00734	3306	118	None	-66	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
	114948	60267	14	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	CHEMBL1743263	60267	14	None	-1	3	Human	8.1	pKi	=	8.1	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Drug Central	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
	6761	67770	19	None	-7	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
	CHEMBL1909072	67770	19	None	-7	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
	1621	2413	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	None	-19	45	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligandBinding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	2600	3750	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	2608	3750	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	5405	3750	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	CHEMBL17157	3750	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	DB00342	3750	74	None	-1	13	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
	1530	2169	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	3827	2169	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	7206	2169	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	CHEMBL534	2169	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	DB00920	2169	50	None	-19	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
	124087	1377	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	7157	1377	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	814	1377	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	CHEMBL1172	1377	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	DB00967	1377	114	None	-5	15	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	None
	2865	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	59	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	60854	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	CHEMBL708	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	DB00246	4112	73	None	-12	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
	135398737	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1212	1649	50	None	-27	66	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	204	1649	50	None	-27	66	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	3372	1649	50	None	-27	66	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	CHEMBL726	1649	50	None	-27	66	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	DB00623	1649	50	None	-27	66	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
	26987	946	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	6063	946	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	671	946	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	CHEMBL1626	946	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	DB00283	946	33	None	-47	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
	2267	557	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	271	557	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	7121	557	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	CHEMBL639	557	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	DB00972	557	71	None	-10	7	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cellsDisplacement of [3H]mesulergine from recombinant human 5-ht2B expressed in CHO cells	Drug Central	381	3	0	4	4.3	CN1CCCC(CC1)n1nc(Cc2ccc(cc2)Cl)c2c(c1=O)cccc2	None
	3652	4066	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	57	4066	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	60809	4066	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	CHEMBL21536	4066	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	DB15357	4066	79	None	-2	18	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	None
	2585	800	103	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	522	800	103	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	551	800	103	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	CHEMBL723	800	103	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	DB01136	800	103	None	-18	22	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
	102	4096	48	None	-93	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	3659	4096	48	None	-93	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	8969	4096	48	None	-93	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	CHEMBL15245	4096	48	None	-93	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	DB01392	4096	48	None	-93	50	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
	135398745	2893	112	None	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	47	2893	112	None	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	CHEMBL715	2893	112	None	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	DB00334	2893	112	None	-5	66	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
	134	2497	24	3H-5HT	-2	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-2	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-2	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-2	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-2	68	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	3036864	202731	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	Functional	-295	28	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	1615	167767	24	3H-LSD	-2	45	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	CHEMBL43048	167767	24	3H-LSD	-2	45	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
	2470	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	3300	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	5265	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	99	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	CHEMBL267930	3626	50	3H-5HT	-14125	60	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
	1210	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1213	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	2725	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	33036	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	4411	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	616	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	6976	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	716121	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	90475904	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1201353	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL1554789	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	CHEMBL505	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB01114	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	DB13679	915	51	3H-5HT	-1380	21	Human	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	274	5	0	2	3.8	CN(CCC(c1ccccn1)c1ccc(cc1)Cl)C	None
	1150	3849	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	125	3849	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	CHEMBL6640	3849	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	DB08653	3849	121	3H-5HT	-2	25	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	None
	213	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	21830793	91806	10	3H-8-OH-DPAT	-489	46	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	CHEMBL2413154	91806	10	3H-8-OH-DPAT	-489	46	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
	45266826	217664	0	[3H] LSD	2	8	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	177	3	1	2	1.8	CC1=CC=C(C=C1)C(=O)C(C)NC	None
	179	399	115	3H-LSD	-17	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	3H-LSD	-17	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	3H-LSD	-17	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	3H-LSD	-17	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	3H-LSD	-17	51	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	24740863	89129	0	UNDEFINED	1	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
	CHEMBL236610	89129	0	UNDEFINED	1	6	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	385	6	1	5	5.0	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)ccc1Cl	None
	1524	2168	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	197	2168	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	3822	2168	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	88	2168	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	CHEMBL51	2168	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	DB12465	2168	96	3H-5HT	-229	52	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
	5	139	72	3H-KETANSERIN	-1778	55	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-KETANSERIN	-1778	55	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-KETANSERIN	-1778	55	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-KETANSERIN	-1778	55	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	77590	215930	0	3H-5HT	-10	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	124	4	0	2	0.8	COCCOCCl	None
	221	3465	71	3H-5HT	-4	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	3277600	3465	71	3H-5HT	-4	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	CHEMBL323356	3465	71	3H-5HT	-4	14	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
	None	216423	0	UNDEFINED	1	28	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
	206	2476	16	3H-KETANSERIN	-5	25	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	68848	2476	16	3H-KETANSERIN	-5	25	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	CHEMBL12314	2476	16	3H-KETANSERIN	-5	25	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	None
	134551	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	271	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	885	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	CHEMBL1403281	357	27	None	-6	21	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
	135	2515	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	None	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	2247	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	249	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	2603	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	CHEMBL296419	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	DB00637	504	81	None	-4	42	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
	1385580	29245	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
	4615	29245	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
	CHEMBL13828	29245	76	None	-1	5	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	7	1	4	4.1	O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1	None
	191	402	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	201	402	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2170	402	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	CHEMBL1113	402	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	DB00543	402	98	None	-5	29	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
	2601	3751	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	443951	3751	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	56	3751	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL73151	3751	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB13399	3751	33	None	-8	21	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
	135398737	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	None	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	10531	1408	21	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	121	1408	21	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	888	1408	21	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	CHEMBL1732	1408	21	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	DB00320	1408	21	None	-15	24	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
	107715	200922	22	None	-14	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	CHEMBL1255837	200922	22	None	-14	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	CHEMBL601773	200922	22	None	-14	20	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
	135526515	217697	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	301	7	4	3	2.8	CCCCCNC(=N)NN=CC1=CNC2=C1C=C(OC)C=C2	None
	1588	2311	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	28864	2311	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	43	2311	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL157138	2311	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB00589	2311	27	None	-6	44	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	135398737	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	38	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	722	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	CHEMBL42	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	DB00363	955	93	3H-5HT	-2	92	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
	1042	1568	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	148	1568	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	443884	1568	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	CHEMBL119443	1568	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	DB01253	1568	23	None	-7	17	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
	2220	3112	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	27400	3112	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	93	3112	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	CHEMBL294951	3112	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	DB06153	3112	82	None	-1	14	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysisDisplacement of [3H]Mesulergine from human 5-HT2B receptor expressed in HEK293 cells by liquid scintillation counting analysis	Drug Central	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	None
	3337	206344	27	Functional	-75	41	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	Functional	-75	41	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	Functional	-75	41	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	Functional	-75	41	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	Functional	-75	41	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	11978813	718	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	5014	718	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	7672	718	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	CHEMBL2105760	718	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	DB09128	718	79	None	-2	24	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
	133	2479	52	None	-2	43	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	1723	2479	52	None	-2	43	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	28693	2479	52	None	-2	43	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	CHEMBL19215	2479	52	None	-2	43	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	DB13520	2479	52	None	-2	43	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
	277	1289	62	None	-5	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	2913	1289	62	None	-5	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	765	1289	62	None	-5	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	CHEMBL516	1289	62	None	-5	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	DB00434	1289	62	None	-5	46	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
	37	775	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	460	775	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	54746	775	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	CHEMBL1201087	775	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	DB00248	775	60	None	1	17	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysisDisplacement of [125I](+/-)DOI from human 5-HT2B receptor transfected in CHO cell membrane after 60 mins by scintillation counting analysis	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
	11954224	215928	0	None	-66	60	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
	1621	2413	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	17	2413	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	5761	2413	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	CHEMBL263881	2413	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	DB04829	2413	17	Functional	-19	45	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
	135	2515	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-3	58	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	None	215944	0	3H-KETANSERIN	-147	2	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	259	5	1	3	2.6	CCC1=CC(=C(C=C1OC)CC(C)N)OC.Cl	None
	3036864	202731	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1256645	202731	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL1814790	202731	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	CHEMBL62	202731	19	3H-5HT	-346	28	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
	213	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	2717	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	5533	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	CHEMBL621	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	DB00656	3824	55	3H-5HT	-5	44	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
	115	3762	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3762	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3762	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	173	3238	95	3H-5HT	1	23	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	5011	3238	95	3H-5HT	1	23	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	CHEMBL18772	3238	95	3H-5HT	1	23	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
	115	3762	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	4296	3762	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	CHEMBL274866	3762	80	3H-5HT	-2	27	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	None
	2337	3232	77	3H-LSD	-15	63	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	50	3232	77	3H-LSD	-15	63	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	5002	3232	77	3H-LSD	-15	63	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	CHEMBL716	3232	77	3H-LSD	-15	63	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	DB01224	3232	77	3H-LSD	-15	63	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
	134	2497	24	3H-5HT	-12	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-12	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-12	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-12	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-12	68	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	119376	1828	48	3H-5HT	-4786	27	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	247	1828	48	3H-5HT	-4786	27	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	CHEMBL33884	1828	48	3H-5HT	-4786	27	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
	71299720	215926	0	3H-5HT	-691	17	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
	1220	187	55	Functional	-1905	45	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	31	187	55	Functional	-1905	45	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	7	187	55	Functional	-1905	45	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	CHEMBL56	187	55	Functional	-1905	45	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
	150	2492	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	1764	2492	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	8226	2492	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	CHEMBL1201356	2492	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	DB00353	2492	21	None	1	16	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
	134	2497	24	3H-5HT	-2	68	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	3H-5HT	-2	68	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	3H-5HT	-2	68	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	3H-5HT	-2	68	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	3H-5HT	-2	68	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	107	141	121	3H-5HT	-12	31	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-12	31	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-12	31	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	107	141	121	3H-5HT	-12	31	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	121	3H-5HT	-12	31	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	121	3H-5HT	-12	31	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	11154555	797	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5037	797	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	7671	797	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL2028019	797	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL3085826	797	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB06016	797	62	None	-39	12	Human	8.0	pKi	=	8.0	Binding	CHO-K1 cells, [3H]LSD (1.2nM)CHO-K1 cells, [3H]LSD (1.2nM)	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	134	2497	24	None	-2	68	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	1775	2497	24	None	-2	68	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	9681	2497	24	None	-2	68	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	CHEMBL1065	2497	24	None	-2	68	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	DB00247	2497	24	None	-2	68	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cellsDisplacement of [3H]mesulergine from human HTR2B expressed in CHO-K1 cells	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
	242	469	124	None	-1	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	34	469	124	None	-1	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	60795	469	124	None	-1	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	CHEMBL1112	469	124	None	-1	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	DB01238	469	124	None	-1	52	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
	5	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	135	2515	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	1796	2515	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	4184	2515	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	CHEMBL6437	2515	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	DB06148	2515	43	3H-5HT	-3	58	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
	46780481	107504	20	None	-57	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	9903970	107504	20	None	-57	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3187365	107504	20	None	-57	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	CHEMBL3544974	107504	20	None	-57	54	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
	5	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	72	3H-5HT	-13	55	Human	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	11848625	5760	0	UNDEFINED	2	6	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
	CHEMBL1078745	5760	0	UNDEFINED	2	6	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	451	8	1	7	4.9	CCOc1cc(CN2CCC(Nc3nc4ccccc4o3)CC2)cc(OC2CCOCC2)c1	None
	62787	206165	21	3H-5HT	-3	10	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	CHEMBL8642	206165	21	3H-5HT	-3	10	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	195	4	1	3	1.6	COc1ccc(OC)c(CC(C)N)c1	None
	7153	97992	77	3H-KETANSERIN	-50	34	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	CHEMBL272942	97992	77	3H-KETANSERIN	-50	34	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
	None	216000	0	3H-5HT	-10	4	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
	None	216425	0	3H-5HT	-43	3	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	419	6	1	4	3.4	C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCOC4=CC=C(C=C4)F.Cl	None
	10624	70271	19	3H-LSD	-7	33	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	138543650	70271	19	3H-LSD	-7	33	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	CHEMBL194378	70271	19	3H-LSD	-7	33	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
	282	1407	0	None	-371	7	Human	7.5	pKi	=	7.5	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	23519215
	522609	1407	0	None	-371	7	Human	7.5	pKi	=	7.5	Binding	Biased for β-arrestin signalling.Biased for β-arrestin signalling.	Guide to Pharmacology	577	5	3	6	2.5	CC(CC1C(=O)N2CCCC2C2(N1C(=O)C(O2)(NC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	23519215
	1621	2413	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	17	2413	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	5761	2413	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	CHEMBL263881	2413	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	DB04829	2413	17	None	-19	45	Human	8.4	pKi	=	8.4	Binding	Biased for β-arrestin sihnalling.Biased for β-arrestin sihnalling.	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	23519215
	10287037	623	0	None	31	2	Human	10.1	pKi	=	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	367	3	0	4	5.1	CCOc1ccc2c(c1)Sc1c(C2=C2CCN(CC2)C)c(OC)ccc1	25666387
	8424	623	0	None	31	2	Human	10.1	pKi	=	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	367	3	0	4	5.1	CCOc1ccc2c(c1)Sc1c(C2=C2CCN(CC2)C)c(OC)ccc1	25666387
	2	3237	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
	2	3237	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
	54562	3237	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
	54562	3237	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
	CHEMBL240773	3237	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	12388666
	CHEMBL240773	3237	23	None	-363	29	Human	5.8	pKi	=	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	15322733
	11658860	2329	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	2941	2329	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	4374	2329	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	CHEMBL360328	2329	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	DB04871	2329	51	None	-1	3	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	195	0	1	1	2.6	Clc1ccc2c(c1)[C@@H](C)CNCC2	18252809
	45275554	3287	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	8427	3287	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	CHEMBL3544975	3287	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	DB12798	3287	0	None	-6	3	Human	7.5	pKi	=	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	492	9	3	6	3.7	COc1cc(N)c(cc1C(=O)NCC1CCN(CC1)CC[C@@H](c1ccc(cc1)F)OC(=O)N)Cl	25316608
	11957541	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	11957541	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	1229	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	1229	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	147	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	147	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	170617	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	170617	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	CHEMBL6616	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	CHEMBL6616	1446	40	None	-6	16	Rat	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8450835
	11957541	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	11957541	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	11957541	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	1229	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	1229	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	1229	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	147	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	147	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	147	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	170617	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	170617	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	170617	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	CHEMBL6616	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	12970106
	CHEMBL6616	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	8078486
	CHEMBL6616	1446	40	None	-2	16	Human	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1CC(N)C)OC	9933142
	161	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
	161	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
	161	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
	4284720	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
	4284720	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
	4284720	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
	CHEMBL1255834	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	12970106
	CHEMBL1255834	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15322733
	CHEMBL1255834	751	6	None	2	6	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	5	2	3	3.7	CC(Cc1c[nH]c2c1cc(OCc1cccs1)cc2)N	15466450
	166	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
	3045227	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
	CHEMBL76781	3334	18	None	1	3	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	226	2	1	2	2.8	C[C@@H](Cn1ccc2c1cc(Cl)c(c2)F)N	15322733
	135	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	135	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	135	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	1796	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	1796	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	1796	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	4184	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	4184	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	4184	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	CHEMBL6437	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	CHEMBL6437	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	CHEMBL6437	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	DB06148	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10455251
	DB06148	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	15322733
	DB06148	2515	43	None	-3	58	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	9459568
	134	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	134	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	134	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	1775	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	1775	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	1775	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	9681	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	9681	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	9681	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	CHEMBL1065	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	CHEMBL1065	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	CHEMBL1065	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	DB00247	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	11104741
	DB00247	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	15322733
	DB00247	2497	24	None	-2	68	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	9459568
	176	1525	0	None	19	4	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
	9930789	1525	0	None	19	4	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
	CHEMBL1628720	1525	0	None	19	4	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	4	1	5	2.8	Nc1cc(N2CCN(CC2)Cc2ccccc2)c(cc1C)[N+](=O)[O-]	15107597
	188	3366	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
	188	3366	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
	196968	3366	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
	196968	3366	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
	CHEMBL473186	3366	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	10455251
	CHEMBL473186	3366	80	None	-1	6	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	2	1	3	4.1	Nc1nc(cc(n1)c1ccc(c2c1cccc2)F)C(C)C	15322733
	3763	217685	0	None	-	1	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	184	2	0	1	2.4	FC(F)OC(Cl)C(F)(F)F	None
	202	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	60835	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	972	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	CHEMBL1175	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	DB00476	1496	77	None	-1	33	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
	3337	206344	27	None	-75	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	65801	206344	27	None	-75	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	66264	206344	27	None	-75	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	91452	206344	27	None	-75	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	CHEMBL87493	206344	27	None	-75	41	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
	4450	178204	69	None	-1	3	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	None
	CHEMBL465026	178204	69	None	-1	3	Human	8.2	pKi	None	8.2	Binding	NoneNone	Drug Central	253	1	0	2	3.2	CN1CCOC(c2ccccc2)c2ccccc2C1	None
	6166	215998	0	None	-4	4	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	330	2	1	3	3.7	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)CO)CCC4=CC(=O)CC[C@]34C	None
	179	399	115	None	-17	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	2159	399	115	None	-17	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	963	399	115	None	-17	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	CHEMBL243712	399	115	None	-17	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	DB06288	399	115	None	-17	51	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
	1357	2468	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	1672	2468	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	224	2468	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	896	2468	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	CHEMBL45	2468	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	DB01065	2468	139	None	-3890	9	Human	5.2	pKi	None	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12750432
	1209	1645	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	203	1645	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	3386	1645	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	CHEMBL41	1645	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	DB00472	1645	75	None	-199	32	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	208	2843	0	None	-69	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	4541	2843	0	None	-69	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	CHEMBL1494	2843	0	None	-69	13	Human	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	4.2	NCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	11104741
	1220	187	55	None	-1905	45	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	1220	187	55	None	-3235	45	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	31	187	55	None	-1905	45	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	31	187	55	None	-3235	45	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	7	187	55	None	-1905	45	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	7	187	55	None	-3235	45	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	CHEMBL56	187	55	None	-1905	45	Human	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	15322733
	CHEMBL56	187	55	None	-3235	45	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	8450835
	1524	2168	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	197	2168	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	3822	2168	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	88	2168	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	CHEMBL51	2168	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	DB12465	2168	96	None	-2691	52	Rat	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8450835
	186	1794	52	None	-426	17	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
	71781	1794	52	None	-426	17	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
	CHEMBL18972	1794	52	None	-426	17	Human	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	15322733
	2470	3626	50	None	-120226	60	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	3300	3626	50	None	-120226	60	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	5265	3626	50	None	-120226	60	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	99	3626	50	None	-120226	60	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	CHEMBL267930	3626	50	None	-120226	60	Rat	5.5	pKi	None	5.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8450835
	2176	3104	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	4828	3104	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	91	3104	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	CHEMBL500	3104	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	DB00960	3104	68	None	-933	27	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	6	3	3	1.9	OC(COc1cccc2c1cc[nH]2)CNC(C)C	15322733
	29	789	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	9805719	789	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	CHEMBL2027925	789	0	None	-2511	9	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	456	5	1	8	3.4	Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1	12130738
	18971832	2402	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	21	2402	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	CHEMBL3186179	2402	0	None	-263	13	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	9395253
	28	3470	46	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	3292447	3470	46	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	CHEMBL20963	3470	46	None	-954	10	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	486	9	1	7	5.2	COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	2202	3110	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	4850	3110	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	49	3110	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	CHEMBL1371770	3110	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	DB12478	3110	96	None	-6	21	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	12388666
	130	3474	47	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
	3378093	3474	47	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
	CHEMBL281350	3474	47	None	-478	13	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	520	3	0	6	5.6	CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	15322733
	143	3489	51	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
	5311096	3489	51	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
	CHEMBL85606	3489	51	None	-158	7	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	438	5	1	4	4.8	N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2	10945872
	175	3628	44	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	68186	3628	44	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	CHEMBL79834	3628	44	None	-331	7	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	185	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	185	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	5311271	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	5311271	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	CHEMBL74355	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	CHEMBL74355	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	DB16351	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	10188965
	DB16351	3975	60	None	-2344	38	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	15322733
	187	3363	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
	187	3363	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
	3693566	3363	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
	3693566	3363	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
	CHEMBL88402	3363	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	15322733
	CHEMBL88402	3363	18	None	-288	5	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	612	11	3	8	3.6	COc1cc(OC)c(cc1C(=O)CCCCN1CCC2(CC1)NC(=O)NC2=O)NS(=O)(=O)c1ccc(cc1)C(F)(F)F	9225287
	1353	1898	93	None	-295	86	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	3559	1898	93	None	-295	86	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	86	1898	93	None	-295	86	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	CHEMBL54	1898	93	None	-295	86	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	DB00502	1898	93	None	-295	86	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	9459568
	109	899	31	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
	2689	899	31	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
	CHEMBL27403	899	31	None	-281	7	Human	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	1	0	4	3.3	CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F	15322733
	2470	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	2470	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	2470	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	3300	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	3300	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	3300	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	5265	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	5265	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	5265	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	99	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	99	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	99	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	CHEMBL267930	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	15322733
	CHEMBL267930	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	8078486
	CHEMBL267930	3626	50	None	-14125	60	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	9459568
	107780	1831	54	None	-676	18	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	14	1831	54	None	-676	18	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	CHEMBL15928	1831	54	None	-676	18	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	6	1	7	5.0	COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C	9303567
	133633	2228	53	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
	177	2228	53	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
	CHEMBL445102	2228	53	None	-87	8	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10869410
	177336	3098	50	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	225	3098	50	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	CHEMBL356359	3098	50	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	DB04873	3098	50	None	-1412	3	Human	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	11504648
	1524	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	1524	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	1524	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	1524	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	1524	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	197	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	197	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	197	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	197	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	197	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	3822	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	3822	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	3822	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	3822	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	3822	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	88	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	88	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	88	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	88	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	88	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	CHEMBL51	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	CHEMBL51	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	CHEMBL51	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	CHEMBL51	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	CHEMBL51	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	DB12465	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	12738034
	DB12465	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	15322733
	DB12465	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8078486
	DB12465	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	8845011
	DB12465	2168	96	None	-229	52	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	9459568
	107992	2536	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	165	2536	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	CHEMBL269521	2536	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	DB12111	2536	49	None	-5	10	Rat	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	8450835
	107992	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	107992	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	165	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	165	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	CHEMBL269521	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	CHEMBL269521	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	DB12111	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	12970106
	DB12111	2536	49	None	-1	10	Human	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	198	1	1	4	0.5	Clc1cncc(n1)N1CCNCC1	15322733
	5268	3629	40	None	-1047	18	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
	53	3629	40	None	-1047	18	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
	CHEMBL300555	3629	40	None	-1047	18	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	379	3	1	5	2.3	O=C1NCN(C21CCN(CC2)CC1COc2c(O1)cccc2)c1ccccc1	9459568
	1574	81	60	None	-3	21	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
	218	81	60	None	-3	21	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
	CHEMBL266591	81	60	None	-3	21	Rat	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	8450835
	198	312	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	82148	312	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	99	312	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	CHEMBL10878	312	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	DB06594	312	126	None	-346	6	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12750432
	177336	3098	50	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	225	3098	50	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	CHEMBL356359	3098	50	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	DB04873	3098	50	None	-1412	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	369	6	1	4	3.7	CCCCN1CCC(CC1)CNC(=O)c1c2OCCCn2c2c1cccc2	15466450
	210	3451	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	2423	3451	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	5160	3451	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	CHEMBL52939	3451	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	DB12163	3451	0	None	-7	3	Human	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	429	13	1	6	3.2	COc1cccc(c1)CCc1ccccc1OCC(OC(=O)CCC(=O)O)CN(C)C	12738034
	195	3544	7	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
	9859407	3544	7	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
	CHEMBL316069	3544	7	None	-25	4	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	0	0	2	2.1	CN1CC[C@H]2[C@@H](C1)c1cccc3c1N(C2)CC3	15322733
	1809	134	32	None	-999	37	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
	1809	134	32	None	-999	37	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	4	134	32	None	-999	37	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
	4	134	32	None	-999	37	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	CHEMBL18840	134	32	None	-999	37	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	15322733
	CHEMBL18840	134	32	None	-999	37	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	1809	134	32	None	-1659	37	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	1809	134	32	None	-1659	37	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
	4	134	32	None	-1659	37	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	4	134	32	None	-1659	37	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
	CHEMBL18840	134	32	None	-1659	37	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8078486
	CHEMBL18840	134	32	None	-1659	37	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	3	3	2	0.8	NCCc1c[nH]c2c1cc(cc2)C(=O)N	8450835
	129	3414	10	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
	9868452	3414	10	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
	CHEMBL65280	3414	10	None	-562	9	Human	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	7	1	4	4.8	N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1	10869410
	193	3480	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
	193	3480	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
	3644637	3480	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
	3644637	3480	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
	CHEMBL14563	3480	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	15322733
	CHEMBL14563	3480	46	None	-707	4	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	3	1	4	5.1	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1ccc(nc1)Oc1cccnc1C	9225286
	228	444	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	33	444	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	6005	444	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	CHEMBL53	444	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	DB00714	444	28	None	-5	24	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	12388666
	173	3238	95	None	-3	23	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
	5011	3238	95	None	-3	23	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
	CHEMBL18772	3238	95	None	-3	23	Rat	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	8450835
	108029	3389	57	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
	23	3389	57	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
	CHEMBL18785	3389	57	None	-125	13	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	15322733
	221	3465	71	None	-4	14	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
	3277600	3465	71	None	-4	14	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
	CHEMBL323356	3465	71	None	-4	14	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	15322733
	170	2941	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
	9796408	2941	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
	CHEMBL506999	2941	0	None	-6	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	265	1	1	3	2.2	FC(c1ccc(nc1Cl)N1CCNCC1)(F)F	15322733
	194	3481	31	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
	443391	3481	31	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
	CHEMBL14460	3481	31	None	-100	3	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	428	3	1	4	5.5	O=C(N1CCc2c1cc(c(c2)C)C(F)(F)F)Nc1ccc(nc1)Oc1cccnc1C	10737744
	1150	3849	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	1150	3849	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	125	3849	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	125	3849	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	CHEMBL6640	3849	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	CHEMBL6640	3849	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	DB08653	3849	121	None	-2	25	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	15322733
	DB08653	3849	121	None	-8	25	Rat	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	160	2	2	1	1.7	NCCc1c[nH]c2c1cccc2	8450835
	173	3238	95	None	1	23	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
	5011	3238	95	None	1	23	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
	CHEMBL18772	3238	95	None	1	23	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	15322733
	115	3762	80	None	-2	27	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
	4296	3762	80	None	-2	27	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
	CHEMBL274866	3762	80	None	-2	27	Rat	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	8450835
	213	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	213	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	2717	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	2717	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	5533	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	5533	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	CHEMBL621	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	CHEMBL621	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	DB00656	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	11104741
	DB00656	3824	55	None	-5	44	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	15322733
	115	3762	80	None	-1	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
	4296	3762	80	None	-1	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
	CHEMBL274866	3762	80	None	-1	27	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	1	1	2	2.1	FC(c1cccc(c1)N1CCNCC1)(F)F	15322733
	31101	726	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	35	726	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	403	726	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	CHEMBL493	726	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	DB01200	726	40	None	-26	36	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
	135	2515	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	1796	2515	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	4184	2515	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	CHEMBL6437	2515	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	DB06148	2515	43	None	-37	58	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	8450835
	15897	2840	0	None	12	37	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
	215	2840	0	None	12	37	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
	CHEMBL1979333	2840	0	None	12	37	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	11104741
	12895728	2841	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	217	2841	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	CHEMBL250881	2841	0	None	-	1	Human	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	102	4096	48	None	-100	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	3659	4096	48	None	-100	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	8969	4096	48	None	-100	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	CHEMBL15245	4096	48	None	-100	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	DB01392	4096	48	None	-100	50	Rat	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	157	2056	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
	157	2056	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
	9840090	2056	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
	9840090	2056	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
	CHEMBL134519	2056	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	15322733
	CHEMBL134519	2056	7	None	-20	4	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	9857084
	10	720	28	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
	3654103	720	28	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
	CHEMBL534232	720	28	None	-3	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	406	6	1	3	4.7	Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O	9303567
	206	2476	16	None	-26	25	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
	68848	2476	16	None	-26	25	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
	CHEMBL12314	2476	16	None	-26	25	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	8450835
	171	2943	0	None	-5	3	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	233	3	1	3	1.9	COc1ccc2c(c1O[C@@H]1CNCC1)CCC2	15322733
	9794656	2943	0	None	-5	3	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	233	3	1	3	1.9	COc1ccc2c(c1O[C@@H]1CNCC1)CCC2	15322733
	136	3267	32	None	-63	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	223	3267	32	None	-63	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	643606	3267	32	None	-63	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	CHEMBL10347	3267	32	None	-63	16	Rat	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8450835
	155	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	155	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	163	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	163	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	62065	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	62065	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	CHEMBL6607	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	CHEMBL6607	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	DB01484	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	15322733
	DB01484	725	25	None	-5	13	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	3	2.4	COc1cc(Br)c(cc1CC(N)C)OC	9933142
	219050	3348	25	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
	52	3348	25	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
	CHEMBL431367	3348	25	None	-194	21	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	12388666
	168	3951	15	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
	6604042	3951	15	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
	CHEMBL309760	3951	15	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	254	2	1	2	2.2	C[C@@H](CN1CCc2c1cc(Br)cc2)N	15322733
	153	1447	9	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
	6603801	1447	9	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
	CHEMBL1434583	1447	9	None	-25	3	Human	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@@H](N)C)OC	15322733
	1355	1998	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	142	1998	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	CHEMBL478	1998	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	DB12110	1998	88	None	-1	16	Rat	7.6	pKi	None	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	8450835
	102	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	102	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	102	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	3659	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	3659	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	3659	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	8969	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	8969	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	8969	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	CHEMBL15245	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	CHEMBL15245	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	CHEMBL15245	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	DB01392	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10455251
	DB01392	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	8078486
	DB01392	4096	48	None	-93	50	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	157	2056	7	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
	9840090	2056	7	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
	CHEMBL134519	2056	7	None	-20	4	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	321	4	1	3	2.2	COc1cc(I)c(cc1C[C@H](N)C)OC	12954071
	3652	4066	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	57	4066	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	60809	4066	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	CHEMBL21536	4066	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	DB15357	4066	79	None	-2	18	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	9884068
	108029	3389	57	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
	23	3389	57	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
	CHEMBL18785	3389	57	None	-15	13	Rat	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	228	2	2	2	2.6	COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1	8450835
	13878025	2411	0	None	-19	3	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
	184	2411	0	None	-19	3	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
	CHEMBL52422	2411	0	None	-19	3	Rat	7.9	pKi	None	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	342	3	2	4	2.4	CC(C(OC(=O)C1CN(C)C2C(C1)c1cccc3c1c(C2)c[nH]3)C)O	8450835
	1355	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	1355	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	1355	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	1355	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	1355	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	142	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	142	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	142	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	142	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	142	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	CHEMBL478	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	CHEMBL478	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	CHEMBL478	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	CHEMBL478	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	CHEMBL478	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	DB12110	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	11104741
	DB12110	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	12970106
	DB12110	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	15322733
	DB12110	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9459568
	DB12110	1998	88	None	-1	16	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	196	1	1	2	1.8	Clc1cccc(c1)N1CCNCC1	9933142
	5	139	72	None	-29	55	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	5202	139	72	None	-29	55	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	CHEMBL39	139	72	None	-29	55	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	DB08839	139	72	None	-29	55	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8450835
	107	141	121	None	-12	31	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
	1833	141	121	None	-12	31	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
	CHEMBL8165	141	121	None	-12	31	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	8450835
	152	363	29	None	-1	19	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
	2107	363	29	None	-1	19	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
	CHEMBL275854	363	29	None	-1	19	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8450835
	199	391	0	None	-5	5	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
	9821951	391	0	None	-5	5	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
	CHEMBL160293	391	0	None	-5	5	Rat	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	393	3	1	3	4.6	O=C([C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C)NC1CCCCC1	8450835
	216	2842	32	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	9815618	2842	32	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	CHEMBL253811	2842	32	None	-	1	Human	8.0	pKi	None	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	203	2	1	1	2.6	C[C@@H](Cc1cccc(c1)C(F)(F)F)N	11104741
	189	3466	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
	189	3466	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
	5163	3466	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
	5163	3466	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
	CHEMBL297784	3466	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15322733
	CHEMBL297784	3466	39	None	-5	17	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	1	1	3	3.2	O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1	15466450
	192	3476	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
	192	3476	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
	443390	3476	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
	443390	3476	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
	CHEMBL14276	3476	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10188965
	CHEMBL14276	3476	54	None	-10	3	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	431	3	1	3	5.5	COc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cc(F)cc(c1)c1cccnc1	10737744
	136	3267	32	None	-8	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	223	3267	32	None	-8	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	643606	3267	32	None	-8	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	CHEMBL10347	3267	32	None	-8	16	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	1	2	4	2.6	COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	9459568
	152	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
	152	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
	152	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
	2107	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
	2107	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
	2107	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
	CHEMBL275854	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15322733
	CHEMBL275854	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	15466450
	CHEMBL275854	363	29	None	1	19	Human	8.1	pKi	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	190	2	3	2	1.8	CC(Cc1c[nH]c2c1cc(O)cc2)N	8078486
	5	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	5	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	5	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	5	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	5	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	5202	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	5202	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	5202	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	5202	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	5202	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	CHEMBL39	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	CHEMBL39	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	CHEMBL39	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	CHEMBL39	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	CHEMBL39	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	DB08839	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	11104741
	DB08839	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	12954071
	DB08839	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15322733
	DB08839	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	15466450
	DB08839	139	72	None	-13	55	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	8078486
	183	2409	0	None	-5	4	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
	3034814	2409	0	None	-5	4	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
	CHEMBL1356280	2409	0	None	-5	4	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	8450835
	133	2479	52	None	-12	43	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	1723	2479	52	None	-12	43	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	28693	2479	52	None	-12	43	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	CHEMBL19215	2479	52	None	-12	43	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	DB13520	2479	52	None	-12	43	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	8450835
	134	2497	24	None	-12	68	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	1775	2497	24	None	-12	68	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	9681	2497	24	None	-12	68	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	CHEMBL1065	2497	24	None	-12	68	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	DB00247	2497	24	None	-12	68	Rat	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	8450835
	2105	3032	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	47811	3032	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	48	3032	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	CHEMBL531	3032	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	DB01186	3032	37	None	-28	33	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
	2601	3751	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	443951	3751	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	56	3751	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	CHEMBL73151	3751	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	DB13399	3751	33	None	-8	21	Human	8.2	pKi	None	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	10331436	323	10	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
	160	323	10	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
	CHEMBL133455	323	10	None	-2	6	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	230	2	2	2	2.4	C[C@@H](Cc1c[nH]c2c1c1CCCOc1cc2)N	12954071
	1621	2413	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	17	2413	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	5761	2413	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	CHEMBL263881	2413	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	DB04829	2413	17	None	-39	45	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12213075
	5074	3307	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	97	3307	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	CHEMBL267777	3307	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	DB12693	3307	80	None	-8	30	Rat	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	8450835
	10449757	3469	35	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
	190	3469	35	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
	CHEMBL2110371	3469	35	None	3	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	337	1	1	2	4.8	O=C(N1CCc2c1cc(Cl)c(c2)C)Nc1cccc2c1cccn2	10188965
	1342	36	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	1342	36	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
	3	36	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	3	36	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
	CHEMBL277120	36	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	CHEMBL277120	36	49	None	-4	19	Rat	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8450835
	135398737	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	135398737	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	135398737	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	38	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	38	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	38	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	722	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	722	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	722	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	CHEMBL42	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	CHEMBL42	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	CHEMBL42	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	DB00363	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	15322733
	DB00363	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9459568
	DB00363	955	93	None	-2	92	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	9732398
	167	3405	0	None	-3	5	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	7	0	5	3.6	Fc1ccc(cc1)C(=O)CC1CCN(C1)CCOc1cccc2c1OCCO2	9732398
	9821498	3405	0	None	-3	5	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	385	7	0	5	3.6	Fc1ccc(cc1)C(=O)CC1CCN(C1)CCOc1cccc2c1OCCO2	9732398
	135409453	3744	41	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
	226	3744	41	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
	CHEMBL76370	3744	41	None	2	2	Human	8.4	pKi	None	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	15466450
	191	3472	52	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
	443389	3472	52	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
	CHEMBL276140	3472	52	None	-1	3	Human	8.6	pKi	None	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	2	1	3	4.4	CSc1cc2CCN(c2cc1C(F)(F)F)C(=O)Nc1cccnc1	15322733
	206	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
	206	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
	206	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
	68848	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
	68848	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
	68848	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
	CHEMBL12314	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15107597
	CHEMBL12314	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	15322733
	CHEMBL12314	2476	16	None	-1	25	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	362	3	1	4	1.3	CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C	9459568
	1342	36	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	1342	36	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
	3	36	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	3	36	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
	CHEMBL277120	36	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	8078486
	CHEMBL277120	36	49	None	2	19	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	212	1	1	2	2.2	N1CCN(CC1)c1cccc2c1cccc2	9459568
	1043	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	1043	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	149	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	149	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	8223	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	8223	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	CHEMBL442	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	CHEMBL442	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	DB00696	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	11104741
	DB00696	1569	14	None	-22	29	Human	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	15322733
	133	2479	52	None	-2	43	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	1723	2479	52	None	-2	43	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	28693	2479	52	None	-2	43	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	CHEMBL19215	2479	52	None	-2	43	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	DB13520	2479	52	None	-2	43	Human	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	15322733
	37	775	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	460	775	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	54746	775	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	CHEMBL1201087	775	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	DB00248	775	60	None	1	17	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
	1588	2311	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	28864	2311	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	43	2311	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	CHEMBL157138	2311	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	DB00589	2311	27	None	-6	44	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
	4106	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	4106	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	5358812	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	5358812	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	89	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	89	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	CHEMBL93240	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	15322733
	CHEMBL93240	2485	22	None	-3	34	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	9459568
	5074	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	5074	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	5074	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	5074	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	97	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	97	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	97	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	97	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	CHEMBL267777	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	CHEMBL267777	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	CHEMBL267777	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	CHEMBL267777	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	DB12693	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10188965
	DB12693	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	10455251
	DB12693	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	15322733
	DB12693	3307	80	None	-2	30	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	9459568
	183	2409	0	None	2	4	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
	3034814	2409	0	None	2	4	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
	CHEMBL1356280	2409	0	None	2	4	Human	9.0	pKi	None	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	384	4	1	5	3.5	CC(C(O)C)OC(=O)[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C(C)C	9459568
	154	2344	0	None	-1	4	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	15322733
	638252	2344	0	None	-1	4	Human	9.0	pKi	None	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	323	3	1	2	2.9	CCN(C(=O)[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	15322733
	150	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	150	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	1764	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	1764	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	8226	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	8226	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	CHEMBL1201356	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	CHEMBL1201356	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733
	DB00353	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	11104741
	DB00353	2492	21	None	1	16	Human	9.3	pKi	None	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	15322733

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)