Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL93240 5ht7r_human Human Yes 9.2 EC50 = 0.6 nM Bind
Displacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]lysergic acid from human recombinant 5HT7 receptor expressed in CHO cells
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL225571 5ht7r_cavpo Guinea pig No 5.0 EC50 = 10000 nM Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
450 9 1 5 4.5 O=C(CCCCCN1CCN(c2ccccc2[N+](=O)[O-])CC1)NC1CCCc2ccccc21
CHEMBL4218801 5ht7r_human Human No 7.0 EC50 = 112.2 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
248 1 1 3 2.7 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)Cl
CHEMBL4218801 5ht7r_human Human No 7.0 EC50 = 113 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
248 1 1 3 2.7 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)Cl
CHEMBL243955 5ht7r_cavpo Guinea pig No 5.9 EC50 = 1170 nM Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL4218672 5ht7r_human Human No 6.9 EC50 = 134.9 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
232 1 1 3 2.2 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)F
CHEMBL4218672 5ht7r_human Human No 6.9 EC50 = 135 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
232 1 1 3 2.2 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)F
CHEMBL39 5ht7r_human Human Yes 7.8 EC50 = 15 nM Funct
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4207884 5ht7r_human Human Yes 6.8 EC50 = 162 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
247 1 2 2 2.4 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)Cl
CHEMBL4207884 5ht7r_human Human Yes 6.8 EC50 = 162.2 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
247 1 2 2 2.4 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)Cl
CHEMBL4210782 5ht7r_human Human No 6.8 EC50 = 165 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
227 1 2 2 2.1 CC1=CC=C(C=C1)C2=NNC3=C2CCNCC3
CHEMBL4210782 5ht7r_human Human No 6.8 EC50 = 166.0 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
227 1 2 2 2.1 CC1=CC=C(C=C1)C2=NNC3=C2CCNCC3
CHEMBL39 5ht7r_human Human Yes 7.8 EC50 = 17 nM Funct
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL222477 5ht7r_cavpo Guinea pig No 4.8 EC50 = 17000 nM Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
439 8 1 3 5.2 O=C(CCCCCN1CCN(c2ccccc2Cl)CC1)NC1CCCc2ccccc21
CHEMBL243954 5ht7r_cavpo Guinea pig Yes 5.8 EC50 = 1770 nM Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL222755 5ht7r_human Human No 5.7 EC50 = 1820 nM Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL4209274 5ht7r_human Human Yes 6.7 EC50 = 186.2 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
231 1 2 2 1.9 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)F
CHEMBL4209274 5ht7r_human Human Yes 6.7 EC50 = 188 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
231 1 2 2 1.9 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)F
CHEMBL3321794 5ht7r_human Human No 6.6 EC50 = 230 nM Funct
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1
CHEMBL389718 5ht7r_human Human No 5.6 EC50 = 2460 nM Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL225284 5ht7r_human Human Yes 5.6 EC50 = 2560 nM Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL494709 5ht7r_cavpo Guinea pig No 6.5 EC50 = 310 nM Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1
CHEMBL445334 5ht7r_human Human No 6.5 EC50 = 310 nM Funct
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
320 5 0 2 3.4 O=C1Cc2ccccc2N1CCCCN1CCc2ccccc2C1
CHEMBL3943658 5ht7r_human Human Yes 5.5 EC50 = 3162.3 nM Funct
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1
CHEMBL3943658 5ht7r_human Human Yes 5.5 EC50 = 3200 nM Funct
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
241 4 1 2 3.4 CNCc1ccc(C)c(-c2ccccc2OC)c1
CHEMBL4215875 5ht7r_human Human No 7.4 EC50 = 40.7 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
228 1 1 3 2.3 CC1=CC=C(C=C1)C2=NOC3=C2CCNCC3
CHEMBL4215875 5ht7r_human Human No 7.4 EC50 = 40.8 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
228 1 1 3 2.3 CC1=CC=C(C=C1)C2=NOC3=C2CCNCC3
CHEMBL39 5ht7r_human Human Yes 7.3 EC50 = 47.9 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 7.3 EC50 = 48 nM Funct
Agonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assayAgonist activity at tTA containing TCS cleavage site-fused 5-HT7 receptor (unknown origin) expressed in tTA-dependent luciferase reporter/TEV-fused beta-arrestin2 expressing HTLA cells assessed as induction of beta-arrestin2 recruitment after 22 hrs by Tango assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL492480 5ht7r_cavpo Guinea pig No 6.3 EC50 = 490 nM Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
467 8 0 3 5.6 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCc2ccccc2C1
CHEMBL18840 5ht7r_human Human Yes 8.3 EC50 = 5.1 nM Funct
Agonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assayAgonist activity at human 5HT7 receptor expressed in CHO-K1 cells by calcium 4 dye based FLIPR assay
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL39 5ht7r_human Human Yes 8.3 EC50 = 5.4 nM Bind
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 8.2 EC50 = 5.7 nM Bind
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assayAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells by LANCE TR-FRET assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 8.2 EC50 = 5.8 nM Funct
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 8.2 EC50 = 5.8 nM Funct
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL3961059 5ht7r_human Human No 6.3 EC50 = 549.5 nM Funct
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1
CHEMBL3961059 5ht7r_human Human No 6.3 EC50 = 550 nM Funct
Agonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assayAgonist activity at human 5-HT7R expressed in HEK293 cells assessed as induction of cAMP levels treated for 10 mins measured after 30 mins by D2-dye based fluorescence assay
261 4 1 2 3.7 CNCc1ccc(Cl)c(-c2ccccc2OC)c1
CHEMBL371300 5ht7r_human Human Yes 5.3 EC50 = 5600 nM Funct
Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay
191 2 2 4 1.1 C[C@H](N)Cn1ncc2ccc(O)cc21
CHEMBL3321798 5ht7r_human Human No 7.2 EC50 = 60 nM Funct
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1
CHEMBL522691 5ht7r_cavpo Guinea pig Yes 6.2 EC50 = 600 nM Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL18840 5ht7r_human Human Yes 6.2 EC50 = 630 nM Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL18840 5ht7r_cavpo Guinea pig Yes 6.2 EC50 = 630 nM Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL18840 5ht7r_cavpo Guinea pig Yes 6.2 EC50 = 630 nM Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL224820 5ht7r_human Human No 5.2 EC50 = 6320 nM Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL39 5ht7r_human Human Yes 8.2 EC50 = 7 nM Funct
Agonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assayAgonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as increase in serotonin-induced cAMP level after 1 hr by TR-FRET assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 7.2 EC50 = 70 nM Funct
Agonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAgonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell incubated for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL222188 5ht7r_cavpo Guinea pig No 5.1 EC50 = 8000 nM Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
405 8 1 3 4.6 O=C(CCCCCN1CCN(c2ccccc2)CC1)NC1CCCc2ccccc21
CHEMBL243744 5ht7r_cavpo Guinea pig No 6.1 EC50 = 900 nM Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL39 5ht7r_human Human Yes 9.6 IC50 = 0.3 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 9.6 IC50 = 0.3 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 9.5 IC50 = 0.3 nM Bind
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4128926 5ht7r_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12
CHEMBL39 5ht7r_human Human Yes 9.3 IC50 = 0.5 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 9.3 IC50 = 0.5 nM Bind
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 9.2 IC50 = 0.6 nM Bind
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL93240 5ht7r_human Human Yes 9.1 IC50 = 0.8 nM Funct
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL282199 5ht7r_human Human Yes 9.1 IC50 = 0.9 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.0 IC50 = 0.9 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.0 IC50 = 0.9 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL93240 5ht7r_human Human Yes 8.8 IC50 = 1.5 nM Funct
Antagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulationAntagonist activity at human recombinant 5-HT7 receptor assessed as inhibition of serotonin-induced cAMP accumulation
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL39 5ht7r_human Human Yes 8.8 IC50 = 1.5 nM Bind
Inhibition of human 5HT7 receptorInhibition of human 5HT7 receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL4753511 5ht7r_human Human No 7.0 IC50 = 100 nM Funct
Inverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assayInverse agonist activity at 5-HT7 receptor (unknown origin) by cAMP functional assay
273 2 1 3 3.0 CC(C)n1nc2c(c1-c1ccc(F)cc1)CCNCC2
CHEMBL1278088 5ht7r_human Human Yes 6.0 IC50 = 1000 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
432 6 1 7 2.5 Nn1c(CCCCN2CCN(c3ccc4ccccc4n3)CC2)nc2c(c1=O)CCCC2
CHEMBL411442 5ht7r_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL411442 5ht7r_human Human No 6.0 IC50 = 1000 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL2393245 5ht7r_human Human No 6.0 IC50 = 1003 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
364 4 2 4 4.2 Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL3040361 5ht7r_human Human No 6.0 IC50 = 1003 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
364 4 2 4 4.2 Clc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL1222138 5ht7r_human Human No 6.0 IC50 = 1006 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
373 5 0 4 3.0 CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccccc1
CHEMBL3769612 5ht7r_human Human No 6.0 IC50 = 1011 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
454 6 2 5 2.4 Cc1ccc(C)c(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1
CHEMBL492793 5ht7r_human Human No 7.0 IC50 = 103 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
457 8 1 5 3.5 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1
CHEMBL4209888 5ht7r_human Human No 6.0 IC50 = 1050 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1
CHEMBL4300899 5ht7r_human Human No 6.0 IC50 = 1050 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
354 7 0 4 3.9 COc1ccccc1N1CCN(CCCOc2ccc(C)cc2C)CC1
CHEMBL2393244 5ht7r_human Human No 6.0 IC50 = 1059 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
348 4 2 4 3.6 Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL3040288 5ht7r_human Human No 6.0 IC50 = 1059 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
348 4 2 4 3.6 Fc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL495250 5ht7r_human Human No 7.0 IC50 = 107 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
471 8 1 5 3.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1
CHEMBL260073 5ht7r_human Human No 7.0 IC50 = 109.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
515 8 1 6 4.3 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL260514 5ht7r_human Human No 7.0 IC50 = 109.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL260901 5ht7r_human Human No 6.0 IC50 = 1099.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL411868 5ht7r_human Human No 6.0 IC50 = 1099.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL1852341 5ht7r_human Human No 8.0 IC50 = 11 nM Bind
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
485 7 1 5 4.7 Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1
CHEMBL3216098 5ht7r_human Human No 8.0 IC50 = 11 nM Bind
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
485 7 1 5 4.7 Cc1nc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1
CHEMBL93240 5ht7r_human Human Yes 8.0 IC50 = 11.3 nM Funct
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL260907 5ht7r_human Human No 7.9 IC50 = 12.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
CHEMBL260073 5ht7r_human Human No 7.0 IC50 = 110 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
515 8 1 6 4.3 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL260514 5ht7r_human Human No 7.0 IC50 = 110 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL601659 5ht7r_human Human No 7.0 IC50 = 110 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
473 9 0 4 4.6 O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1
CHEMBL260901 5ht7r_human Human No 6.0 IC50 = 1100 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL411868 5ht7r_human Human No 6.0 IC50 = 1100 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL6437 5ht7r_human Human Yes 6.9 IC50 = 114.8 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
CHEMBL602060 5ht7r_human Human No 6.9 IC50 = 117 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
463 9 0 4 4.5 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1
CHEMBL116735 5ht7r_human Human No 5.9 IC50 = 1170 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
480 9 0 2 5.8 O=C(CCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
CHEMBL259776 5ht7r_human Human No 6.9 IC50 = 120.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
CHEMBL260969 5ht7r_human Human No 5.9 IC50 = 1199.5 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL4582321 5ht7r_human Human No 7.9 IC50 = 12 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
557 11 1 7 4.5 CCOc1ccccc1N1CCN(CCCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1
CHEMBL260907 5ht7r_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
CHEMBL495678 5ht7r_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
477 7 1 4 4.3 O=S(=O)(NCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)c1ccc2ccccc2c1
CHEMBL602677 5ht7r_human Human No 7.9 IC50 = 12.3 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
494 10 0 6 3.9 COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2cccc3cccnc23)CC1
CHEMBL4764679 5ht7r_human Human No 7.9 IC50 = 12.5 nM Funct
Antagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assayAntagonist activity at human 5HT7 receptor expressed in CHO-K1 cells assessed as inhibition of 5CT-induced calcium flux incubated for 60 mins at 37 degC followed by 15 mins incubation at room temperature and subsequent 5CT addition by calcium 4 dye based FLIPR assay
437 6 0 5 4.2 CN1CCc2ccc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)cc2C1=O
CHEMBL12314 5ht7r_human Human Yes 6.9 IC50 = 120 nM Funct
Antagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated controlAntagonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as inhibition of serotonon-induced increase in cAMP levels by HTRF assay relative to untreated control
362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C
CHEMBL259776 5ht7r_human Human No 6.9 IC50 = 120 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2)CC1
CHEMBL260969 5ht7r_human Human No 5.9 IC50 = 1200 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL601249 5ht7r_human Human No 6.9 IC50 = 121 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
443 10 0 5 3.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1
CHEMBL584046 5ht7r_human Human No 5.9 IC50 = 1217 nM Bind
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
363 5 0 5 3.1 CN(C)CCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21
CHEMBL600012 5ht7r_human Human No 5.9 IC50 = 1236 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
505 9 0 4 5.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1
CHEMBL495212 5ht7r_human Human No 6.9 IC50 = 124 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
477 7 1 4 4.6 O=S(=O)(NCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccc2ccccc2c1
CHEMBL601855 5ht7r_human Human No 6.9 IC50 = 124 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
511 10 0 5 4.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CC2)cc1
CHEMBL4636148 5ht7r_human Human No 6.9 IC50 = 125 nM Funct
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
293 1 2 2 2.9 CN1CCc2cccc3c2C1Cc1ccc(NC(N)=O)cc1-3
CHEMBL260074 5ht7r_human Human No 6.9 IC50 = 130 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
515 8 1 6 4.3 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL260970 5ht7r_human Human No 6.9 IC50 = 130 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL260074 5ht7r_human Human No 6.9 IC50 = 130.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
515 8 1 6 4.3 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL260970 5ht7r_human Human No 6.9 IC50 = 130.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL258524 5ht7r_human Human No 5.9 IC50 = 1300 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
529 9 1 7 3.8 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1
CHEMBL258524 5ht7r_human Human No 5.9 IC50 = 1300.2 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
529 9 1 7 3.8 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1
CHEMBL565745 5ht7r_human Human No 5.9 IC50 = 1362 nM Bind
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
335 4 1 5 2.5 NCCn1cc(S(=O)(=O)c2cccc(Cl)c2)c2cccnc21
CHEMBL3771309 5ht7r_human Human No 5.9 IC50 = 1388 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3cccc(Cl)c3Cl)CC2)C1=O
CHEMBL259625 5ht7r_human Human No 5.9 IC50 = 1399.6 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
497 8 1 7 3.2 COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL494428 5ht7r_human Human No 6.9 IC50 = 140 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
427 7 1 4 3.5 O=S(=O)(NCCCN1CCN(c2ccccc2F)CC1)c1ccc2ccccc2c1
CHEMBL259625 5ht7r_human Human No 5.9 IC50 = 1400 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
497 8 1 7 3.2 COc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL1642116 5ht7r_human Human No 6.8 IC50 = 143 nM Bind
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
435 3 0 5 3.4 CN1CCN(c2ccc3c(c2)N(S(=O)(=O)c2ccc4ccccc4c2)CCC3=O)CC1
CHEMBL21343 5ht7r_human Human Yes 6.8 IC50 = 143 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
309 3 2 2 2.6 CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2NC1
CHEMBL115249 5ht7r_human Human No 5.8 IC50 = 1430 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
396 9 0 4 4.0 CCOc1ccc(CCOC(=O)N2CCN(CCCc3ccccc3)CC2)cc1
CHEMBL326263 5ht7r_human Human No 5.8 IC50 = 1440 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
503 9 0 4 5.7 N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1
CHEMBL601673 5ht7r_human Human No 6.8 IC50 = 147 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
431 9 0 4 3.4 O=S(=O)(c1ccc(F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1
CHEMBL410722 5ht7r_human Human No 5.8 IC50 = 1499.7 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL3343672 5ht7r_human Human No 7.8 IC50 = 15 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@]1(CCCO1)c1ccccc1-2
CHEMBL410722 5ht7r_human Human No 5.8 IC50 = 1500 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL267615 5ht7r_human Human Yes 5.8 IC50 = 1500 nM Bind
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
246 5 1 2 2.8 CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC
CHEMBL602284 5ht7r_human Human No 5.8 IC50 = 1508 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
523 9 0 4 5.8 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1
CHEMBL601457 5ht7r_human Human No 6.8 IC50 = 152 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
463 9 0 4 4.5 O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1
CHEMBL2393243 5ht7r_human Human No 5.8 IC50 = 1564 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
330 4 2 4 3.5 c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1
CHEMBL3040324 5ht7r_human Human No 5.8 IC50 = 1564 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
330 4 2 4 3.5 c1ccc(Cc2nc3c(c(Nc4ccccc4)n2)CCNCC3)cc1
CHEMBL1221497 5ht7r_human Human No 5.8 IC50 = 1582 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
381 4 1 4 3.4 CN1CCN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)CC1
CHEMBL260706 5ht7r_human Human No 6.8 IC50 = 160.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
549 8 1 6 4.9 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL3343670 5ht7r_human Human No 7.8 IC50 = 16 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2
CHEMBL3545812 5ht7r_human Human No 7.8 IC50 = 16 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2
CHEMBL261742 5ht7r_human Human No 7.8 IC50 = 16 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1
CHEMBL406221 5ht7r_human Human No 7.8 IC50 = 16 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1
CHEMBL261742 5ht7r_human Human No 7.8 IC50 = 16 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2cccc(OC)c2)CC1
CHEMBL406221 5ht7r_human Human No 7.8 IC50 = 16 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccc(OC)cc2)CC1
CHEMBL260706 5ht7r_human Human No 6.8 IC50 = 160 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
549 8 1 6 4.9 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL601886 5ht7r_human Human No 6.8 IC50 = 160 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
574 9 0 5 6.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1
CHEMBL4591601 5ht7r_human Human No 6.8 IC50 = 162.2 nM Bind
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC
CHEMBL4591601 5ht7r_human Human No 6.8 IC50 = 163 nM Bind
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC
CHEMBL595449 5ht7r_human Human No 5.8 IC50 = 1713 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
350 4 1 5 4.0 CN(C)Cc1nc(-c2ccc(C(C)(C)C)cc2)n(-c2cccc(O)c2)n1
CHEMBL600822 5ht7r_human Human No 6.8 IC50 = 172 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
515 11 0 6 4.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CCCCC2)cc1
CHEMBL81485 5ht7r_human Human No 7.7 IC50 = 18.6 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
280 2 1 3 3.1 CNCC1CC2c3ccccc3Cc3ccccc3N2O1
CHEMBL2376484 5ht7r_human Human No 5.8 IC50 = 1800 nM Bind
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
360 3 2 4 3.1 Cc1[nH]c2ccc(OS(=O)(=O)C(F)(F)F)cc2c1C1=CCNCC1
CHEMBL3771222 5ht7r_human Human No 5.7 IC50 = 1807 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
516 8 2 5 3.4 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(C(c3ccccc3)c3ccccc3)CC2)C1=O
CHEMBL4207653 5ht7r_human Human No 5.7 IC50 = 1840 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1
CHEMBL4302655 5ht7r_human Human No 5.7 IC50 = 1840 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2c(C)cc(C)cc2C)CC1
CHEMBL603272 5ht7r_human Human No 6.7 IC50 = 188 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
493 10 0 5 4.5 COc1ccccc1N1CCN(CCCN(CC2CC2)S(=O)(=O)c2ccc3ccccc3c2)CC1
CHEMBL258785 5ht7r_human Human No 7.7 IC50 = 19 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1
CHEMBL258785 5ht7r_human Human No 7.7 IC50 = 19.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
543 10 1 7 4.1 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1
CHEMBL259407 5ht7r_human Human No 6.7 IC50 = 190 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
559 10 1 8 3.8 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1
CHEMBL411105 5ht7r_human Human No 6.7 IC50 = 190 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL259407 5ht7r_human Human No 6.7 IC50 = 190.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
559 10 1 8 3.8 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)cc1
CHEMBL411105 5ht7r_human Human No 6.7 IC50 = 190.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
533 8 1 6 4.4 O=C(CCCN1CCN(c2cccc(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL602882 5ht7r_human Human No 6.7 IC50 = 195 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
505 9 0 4 5.6 O=S(=O)(c1cccc2ccccc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1
CHEMBL3927929 5ht7r_human Human No 4.7 IC50 = 19800 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2
CHEMBL259827 5ht7r_human Human No 6.7 IC50 = 200.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL261149 5ht7r_human Human No 6.7 IC50 = 200.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL405892 5ht7r_human Human No 6.7 IC50 = 200.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL3927929 5ht7r_human Human No 4.7 IC50 = 19952.6 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
432 6 0 6 4.4 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)cc2c1OCO2
CHEMBL261232 5ht7r_human Human No 5.7 IC50 = 1999.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
511 9 1 7 3.6 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL122536 5ht7r_human Human No 8.7 IC50 = 2.2 nM Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
205 3 1 2 2.7 CSc1ccc2c(c1)C(CCN)=CC2
CHEMBL39 5ht7r_human Human Yes 8.6 IC50 = 2.6 nM Bind
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL282199 5ht7r_human Human Yes 8.6 IC50 = 2.6 nM Bind
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.6 IC50 = 2.6 nM Bind
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL497749 5ht7r_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
439 8 1 5 3.3 COc1ccccc1N1CCN(CCCNS(=O)(=O)c2ccc3ccccc3c2)CC1
CHEMBL428781 5ht7r_human Human No 7.7 IC50 = 21.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
511 9 1 7 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL259827 5ht7r_human Human No 6.7 IC50 = 200 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL261149 5ht7r_human Human No 6.7 IC50 = 200 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL405892 5ht7r_human Human No 6.7 IC50 = 200 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL261232 5ht7r_human Human No 5.7 IC50 = 2000 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
511 9 1 7 3.6 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL1642123 5ht7r_human Human No 5.7 IC50 = 2007 nM Bind
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
449 3 0 5 3.8 CC1CC(=O)c2c(N3CCN(C)CC3)cccc2N1S(=O)(=O)c1ccc2ccccc2c1
CHEMBL113956 5ht7r_human Human No 5.7 IC50 = 2040 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1
CHEMBL1221452 5ht7r_human Human No 5.7 IC50 = 2044 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
471 6 0 4 5.0 CN1CCN(c2cccc(N(Cc3ccccc3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1
CHEMBL1222364 5ht7r_human Human No 5.7 IC50 = 2059 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
409 5 0 4 3.8 CCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1
CHEMBL260902 5ht7r_human Human No 6.7 IC50 = 209.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
541 10 1 8 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL93240 5ht7r_human Human Yes 7.7 IC50 = 21 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL428781 5ht7r_human Human No 7.7 IC50 = 21 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
511 9 1 7 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL260902 5ht7r_human Human No 6.7 IC50 = 210 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
541 10 1 8 3.6 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL117537 5ht7r_human Human No 5.7 IC50 = 2130 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
476 10 0 2 6.0 O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
CHEMBL4465959 5ht7r_human Human No 6.7 IC50 = 218.8 nM Bind
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1
CHEMBL4465959 5ht7r_human Human No 6.7 IC50 = 219 nM Bind
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assayAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 cells measured after 60 mins in the presence of serotonin by LANCE TR-FRET assay
548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1
CHEMBL260003 5ht7r_human Human No 5.7 IC50 = 2197.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL3321794 5ht7r_human Human No 5.7 IC50 = 2200 nM Funct
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1
CHEMBL260003 5ht7r_human Human No 5.7 IC50 = 2200 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL493416 5ht7r_human Human No 6.7 IC50 = 223 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
439 8 1 5 3.3 COc1cccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)c1
CHEMBL3984812 5ht7r_human Human No 4.6 IC50 = 22908.7 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl
CHEMBL604952 5ht7r_human Human No 5.6 IC50 = 2296 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
574 9 0 5 6.3 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)CC1CCCCC1
CHEMBL260804 5ht7r_human Human No 6.6 IC50 = 230 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
559 10 1 8 3.8 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1
CHEMBL260804 5ht7r_human Human No 6.6 IC50 = 230.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
559 10 1 8 3.8 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccc(F)cc3c2=O)c1
CHEMBL3321798 5ht7r_human Human No 5.6 IC50 = 2300 nM Funct
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
352 6 0 2 4.4 O=C1Cc2ccccc2N1CC/C=C/CCN1CC[C@H]2CCCC[C@@H]2C1
CHEMBL3984812 5ht7r_human Human No 4.6 IC50 = 23100 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
422 6 0 4 5.3 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1Cl
CHEMBL4213352 5ht7r_human Human No 5.6 IC50 = 2340 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1
CHEMBL4300399 5ht7r_human Human No 5.6 IC50 = 2340 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
398 9 0 5 3.8 COc1ccccc1N1CCN(CCOCCOc2cc(C)cc(C)c2C)CC1
CHEMBL261100 5ht7r_human Human No 5.6 IC50 = 2398.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL3770581 5ht7r_human Human No 4.6 IC50 = 23996 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
494 6 2 5 3.1 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C1=O
CHEMBL601885 5ht7r_human Human No 7.6 IC50 = 24 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
536 10 0 6 5.0 COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2cccc3cccnc23)CC1
CHEMBL261100 5ht7r_human Human No 5.6 IC50 = 2400 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL4218672 5ht7r_human Human No 5.6 IC50 = 2454.7 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
232 1 1 3 2.2 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)F
CHEMBL4218672 5ht7r_human Human No 5.6 IC50 = 2463 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
232 1 1 3 2.2 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)F
CHEMBL409107 5ht7r_human Human No 5.6 IC50 = 2500 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
515 8 1 7 3.4 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1
CHEMBL409107 5ht7r_human Human No 5.6 IC50 = 2500.4 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
515 8 1 7 3.4 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)cc1
CHEMBL399203 5ht7r_human Human No 4.6 IC50 = 25000 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
426 4 3 8 3.7 O=[N+]([O-])c1cc(O)c2c(c1)S(=O)(=O)N=C(Nc1ccccc1Oc1ccccc1)N2
CHEMBL4210782 5ht7r_human Human No 5.6 IC50 = 2556 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
227 1 2 2 2.1 CC1=CC=C(C=C1)C2=NNC3=C2CCNCC3
CHEMBL4210782 5ht7r_human Human No 5.6 IC50 = 2570.4 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
227 1 2 2 2.1 CC1=CC=C(C=C1)C2=NNC3=C2CCNCC3
CHEMBL261231 5ht7r_human Human No 7.6 IC50 = 26 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
525 10 1 7 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL261231 5ht7r_human Human No 7.6 IC50 = 26 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
525 10 1 7 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL4633786 5ht7r_human Human No 6.6 IC50 = 260 nM Funct
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
307 0 1 4 3.6 CN1CCc2cccc3c2C1Cc1cc2sc(N)nc2cc1-3
CHEMBL411104 5ht7r_human Human No 6.6 IC50 = 260 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL411104 5ht7r_human Human No 6.6 IC50 = 260.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL407966 5ht7r_human Human No 6.6 IC50 = 269.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL407966 5ht7r_human Human No 6.6 IC50 = 270 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL260756 5ht7r_human Human No 7.5 IC50 = 29.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1
CHEMBL408717 5ht7r_human Human No 7.5 IC50 = 29.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL2312934 5ht7r_human Human No 5.6 IC50 = 2800 nM Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
478 7 1 5 4.0 O=S(=O)(NCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1
CHEMBL1222234 5ht7r_human Human No 5.5 IC50 = 2874 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
423 5 0 4 4.2 CC(C)N(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1cccc2ccccc12
CHEMBL522006 5ht7r_human Human No 6.5 IC50 = 289 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
407 8 1 5 2.3 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3F)CC2)cc1
CHEMBL260756 5ht7r_human Human No 7.5 IC50 = 29 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(OC)cc2)CC1
CHEMBL408717 5ht7r_human Human No 7.5 IC50 = 29 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL12314 5ht7r_human Human Yes 6.5 IC50 = 290 nM Funct
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
362 3 1 4 1.3 CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C
CHEMBL93240 5ht7r_human Human Yes 8.5 IC50 = 3.1 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL282199 5ht7r_human Human Yes 8.4 IC50 = 3.7 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.4 IC50 = 3.7 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL439849 5ht7r_rat Rat Yes 5.5 IC50 = 3000 nM Bind
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
441 7 2 5 4.0 N#Cc1ccc2c(c1)c(CCCCN1CCN(CC1)c1ccc3c(c1)cc(o3)C(=O)N)c[nH]2
CHEMBL364005 5ht7r_human Human Yes 5.5 IC50 = 3000 nM Bind
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
246 1 2 1 3.5 Clc1ccc2c(c1)c(C1=CCNCC1)c([nH]2)C
CHEMBL1221449 5ht7r_human Human No 5.5 IC50 = 3038 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
435 6 0 4 4.2 CN1CCN(c2cccc(N(CC3CC3)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1
CHEMBL267930 5ht7r_human Human Yes 6.5 IC50 = 310 nM Funct
Antagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysisAntagonist activity at human recombinant 5-HT7 receptor expressed in CHOK1 Hunter cell preincubated for 30 mins followed by incubation with agonist for 30 to 60 mins by hit-hunter cAMP assay based chemiluminescence analysis
395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
CHEMBL2376483 5ht7r_human Human No 5.5 IC50 = 3100 nM Bind
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
230 1 2 1 3.0 Cc1[nH]c2ccc(F)cc2c1C1=CCNCC1
CHEMBL601250 5ht7r_human Human No 6.5 IC50 = 316 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
473 11 0 6 3.3 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3OC)CC2)CC2CC2)cc1
CHEMBL603499 5ht7r_human Human No 6.5 IC50 = 316 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
453 8 1 5 3.7 COc1ccccc1N1CCN(CCC(C)NS(=O)(=O)c2ccc3ccccc3c2)CC1
CHEMBL494427 5ht7r_human Human No 5.5 IC50 = 3241 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
439 8 1 5 3.3 COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc4ccccc4c3)CC2)cc1
CHEMBL1086754 5ht7r_human Human No 6.5 IC50 = 333 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
484 7 1 4 5.2 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1C
CHEMBL601458 5ht7r_human Human No 6.5 IC50 = 334 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
481 9 0 4 4.3 O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1
CHEMBL493810 5ht7r_human Human No 6.5 IC50 = 339 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(OC)c3)CC2)cc1
CHEMBL601220 5ht7r_human Human No 6.5 IC50 = 342 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
531 9 0 4 5.5 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1
CHEMBL3770639 5ht7r_human Human No 6.5 IC50 = 343 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
451 6 2 6 1.6 CC1(c2ccc(F)cc2)NC(=O)N(CC(O)CN2CCN(c3ccccc3C#N)CC2)C1=O
CHEMBL3233679 5ht7r_human Human No 6.5 IC50 = 347 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1
CHEMBL3302600 5ht7r_human Human No 6.5 IC50 = 347 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
456 7 2 6 1.8 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1
CHEMBL259236 5ht7r_human Human No 6.5 IC50 = 350.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL261573 5ht7r_human Human No 6.5 IC50 = 350.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
549 8 1 6 4.6 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL602889 5ht7r_human Human No 7.5 IC50 = 35.3 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
482 9 0 5 4.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1
CHEMBL259236 5ht7r_human Human No 6.5 IC50 = 350 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
529 9 1 7 3.8 COc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL261573 5ht7r_human Human No 6.5 IC50 = 350 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
549 8 1 6 4.6 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL603093 5ht7r_human Human No 6.4 IC50 = 363 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
491 7 1 4 4.7 CC(CCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NS(=O)(=O)c1ccc2ccccc2c1
CHEMBL258525 5ht7r_human Human No 6.4 IC50 = 369.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
501 7 1 6 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL427518 5ht7r_human Human No 7.4 IC50 = 37 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1
CHEMBL258525 5ht7r_human Human No 6.4 IC50 = 370 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
501 7 1 6 3.9 O=C(CCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL2376491 5ht7r_human Human No 5.4 IC50 = 3700 nM Bind
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
288 2 2 1 4.5 Cc1[nH]c2ccc(-c3ccccc3)cc2c1C1=CCNCC1
CHEMBL495685 5ht7r_human Human No 6.4 IC50 = 373 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
421 8 1 5 2.7 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccc(F)cc3)CC2)cc1
CHEMBL495890 5ht7r_human Human No 6.4 IC50 = 377 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
403 8 1 5 2.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3)CC2)cc1
CHEMBL2312637 5ht7r_human Human No 5.4 IC50 = 3800 nM Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc2cccnc2c1
CHEMBL523519 5ht7r_human Human No 6.4 IC50 = 384 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
457 8 1 5 3.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(C(F)(F)F)cc3)CC2)cc1
CHEMBL1222363 5ht7r_human Human No 5.4 IC50 = 3865 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
423 6 0 4 4.2 CCCN(c1cccc(N2CCN(C)CC2)c1)S(=O)(=O)c1ccc2ccccc2c1
CHEMBL4218801 5ht7r_human Human No 5.4 IC50 = 3973 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
248 1 1 3 2.7 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)Cl
CHEMBL4218801 5ht7r_human Human No 5.4 IC50 = 3981.1 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
248 1 1 3 2.7 C1CNCCC2=C1C(=NO2)C3=CC=C(C=C3)Cl
CHEMBL409358 5ht7r_human Human No 6.4 IC50 = 399.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL409358 5ht7r_human Human No 6.4 IC50 = 400 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL1086756 5ht7r_human Human No 6.4 IC50 = 408 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
512 9 1 4 6.1 CCCn1c(-c2ccccc2)cc(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1C
CHEMBL3343673 5ht7r_human Human No 7.4 IC50 = 41 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)[C@@]1(CCCO1)c1ccccc1-2
CHEMBL602285 5ht7r_human Human No 6.4 IC50 = 419 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
506 9 0 5 5.0 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1
CHEMBL260029 5ht7r_human Human No 6.4 IC50 = 419.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
509 8 1 6 4.2 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL260648 5ht7r_human Human No 6.4 IC50 = 419.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL259408 5ht7r_human Human No 7.4 IC50 = 42 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL260029 5ht7r_human Human No 6.4 IC50 = 420 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
509 8 1 6 4.2 Cc1ccc(C)c(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL260648 5ht7r_human Human No 6.4 IC50 = 420 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL2164336 5ht7r_human Human Yes 6.4 IC50 = 438 nM Funct
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
268 3 1 3 2.8 COc1ccc(-c2ccccc2N2CCNCC2)cc1
CHEMBL436700 5ht7r_human Human No 7.4 IC50 = 45.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
511 9 1 7 3.6 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL601887 5ht7r_human Human No 6.4 IC50 = 442 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
524 9 0 5 5.2 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CCCCC1
CHEMBL115229 5ht7r_human Human No 5.4 IC50 = 4420 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
394 4 1 8 3.1 O=[N+]([O-])c1cc2c(cc1CN1CC=C(n3c(O)nc4ccccc43)CC1)OCO2
CHEMBL1222362 5ht7r_human Human No 5.4 IC50 = 4425 nM Bind
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
395 4 0 4 3.4 CN1CCN(c2cccc(N(C)S(=O)(=O)c3ccc4ccccc4c3)c2)CC1
CHEMBL260076 5ht7r_human Human No 6.4 IC50 = 449.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL409157 5ht7r_human Human No 6.4 IC50 = 449.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
515 8 1 6 4.3 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL436700 5ht7r_human Human No 7.4 IC50 = 45 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
511 9 1 7 3.6 CCOc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL260076 5ht7r_human Human No 6.4 IC50 = 450 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
567 8 1 6 5.1 O=C(CCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL409157 5ht7r_human Human No 6.4 IC50 = 450 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
515 8 1 6 4.3 O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL602274 5ht7r_human Human No 6.3 IC50 = 456 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
523 9 0 4 5.5 O=S(=O)(c1ccc(C(F)(F)F)cc1)N(CCCN1CCN(c2ccccc2)CC1)CC1CCCCC1
CHEMBL1086626 5ht7r_human Human No 6.3 IC50 = 456 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
470 7 2 3 5.2 Cc1[nH]c(-c2ccccc2)cc1C(=O)NCCCN1CCN(c2cccc(Cl)c2Cl)CC1
CHEMBL259415 5ht7r_human Human No 6.3 IC50 = 460 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
509 8 1 6 4.2 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL259415 5ht7r_human Human No 6.3 IC50 = 460.3 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
509 8 1 6 4.2 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL261572 5ht7r_human Human No 6.3 IC50 = 469.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL493816 5ht7r_human Human No 7.3 IC50 = 47 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
407 8 1 5 2.3 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccc(F)cc3)CC2)cc1
CHEMBL259001 5ht7r_human Human No 7.3 IC50 = 48.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL261572 5ht7r_human Human No 6.3 IC50 = 470 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL494573 5ht7r_human Human No 6.3 IC50 = 476 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
423 8 1 4 3.3 O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccc2ccccc2c1
CHEMBL481245 5ht7r_human Human Yes 4.3 IC50 = 47600 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
314 6 2 5 2.9 COc1cc(/C=C/C(=O)OCCc2ccc(O)cc2)ccc1O
CHEMBL571858 5ht7r_human Human Yes 5.3 IC50 = 4764 nM Bind
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
347 5 0 5 2.6 CN(CCn1cc(c2c1nccc2)S(=O)(=O)c1cccc(c1)F)C
CHEMBL259001 5ht7r_human Human No 7.3 IC50 = 48 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL259199 5ht7r_human Human No 7.3 IC50 = 49.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1
CHEMBL2376482 5ht7r_human Human Yes 6.3 IC50 = 480 nM Bind
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
290 1 2 1 3.6 Cc1[nH]c2ccc(Br)cc2c1C1=CCNCC1
CHEMBL259199 5ht7r_human Human No 7.3 IC50 = 49 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccc(OC)cc2)CC1
CHEMBL600606 5ht7r_human Human No 7.3 IC50 = 49.6 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
481 9 0 4 4.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2ccc(F)cc2)CC1)CC1CC1
CHEMBL1088313 5ht7r_human Human No 6.3 IC50 = 493 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
553 8 1 5 5.8 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1N1CCCCC1
CHEMBL2393246 5ht7r_human Human No 6.3 IC50 = 497 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
360 5 2 5 3.5 COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL3040325 5ht7r_human Human No 6.3 IC50 = 497 nM Bind
Displacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 minsDisplacement of [3H]-LSD from human recombinant 5HT-7 receptor expressed in CHOK1 cell membranes after 120 mins
360 5 2 5 3.5 COc1cccc(Nc2nc(Cc3ccccc3)nc3c2CCNCC3)c1
CHEMBL261151 5ht7r_human Human No 6.3 IC50 = 500 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
513 7 1 6 4.0 Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1
CHEMBL261653 5ht7r_human Human No 6.3 IC50 = 500 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
513 7 1 6 4.0 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1
CHEMBL600210 5ht7r_human Human No 6.3 IC50 = 500 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
535 10 0 5 5.6 COc1ccccc1N1CCN(CCCN(CC2CCCCC2)S(=O)(=O)c2ccc3ccccc3c2)CC1
CHEMBL601037 5ht7r_human Human No 6.3 IC50 = 500 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
458 10 0 6 3.2 O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CC2)cc1
CHEMBL261151 5ht7r_human Human No 6.3 IC50 = 500.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
513 7 1 6 4.0 Cc1cccc(C)c1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)CC1
CHEMBL261653 5ht7r_human Human No 6.3 IC50 = 500.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
513 7 1 6 4.0 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccc(F)cc3)CC2)c(C)c1
CHEMBL410042 5ht7r_human Human No 6.3 IC50 = 510 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
501 7 1 6 3.9 O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL410042 5ht7r_human Human No 6.3 IC50 = 510.5 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
501 7 1 6 3.9 O=C(CCN1CCN(c2ccccc2Cl)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL565552 5ht7r_human Human No 6.3 IC50 = 511 nM Bind
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
379 5 0 5 3.6 CN(C)CCn1cc(S(=O)(=O)c2cccc3ccccc23)c2cccnc21
CHEMBL259408 5ht7r_human Human No 7.3 IC50 = 52 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
533 8 1 6 4.4 O=C(CCCN1CCN(c2ccccc2Cl)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL1088314 5ht7r_human Human No 6.3 IC50 = 524 nM Bind
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
564 8 1 4 6.8 Cc1c(C(=O)NCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc(-c2ccccc2)n1-c1ccc(F)cc1
CHEMBL602279 5ht7r_human Human No 6.3 IC50 = 526 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
441 7 1 4 3.9 CC(CCN1CCN(c2ccc(F)cc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1
CHEMBL495445 5ht7r_human Human No 7.3 IC50 = 53 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
427 7 1 4 3.5 O=S(=O)(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccc2ccccc2c1
CHEMBL494675 5ht7r_human Human Yes 6.3 IC50 = 531 nM Funct
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1
CHEMBL260022 5ht7r_human Human No 7.3 IC50 = 55.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1
CHEMBL261434 5ht7r_human Human No 7.3 IC50 = 55.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL3262428 5ht7r_human Human No 6.3 IC50 = 540 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation
339 7 1 4 3.4 CN(CCCCN1CCN(c2ccccc2)CC1)c1cccc(O)c1
CHEMBL313714 5ht7r_rat Rat Yes 6.3 IC50 = 540 nM Bind
Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells
462 9 3 6 3.6 OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1
CHEMBL260022 5ht7r_human Human No 7.3 IC50 = 55 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
555 11 1 8 4.0 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccccc3c(=O)n2-c2cccc(OC)c2)CC1
CHEMBL261434 5ht7r_human Human No 7.3 IC50 = 55 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL3973160 5ht7r_human Human No 5.3 IC50 = 5570 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC
CHEMBL2312639 5ht7r_human Human No 5.3 IC50 = 5600 nM Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1
CHEMBL4588956 5ht7r_human Human No 5.3 IC50 = 5600 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 minsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 60 mins
377 14 1 4 5.0 CCCCCCCCCCNC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1
CHEMBL3973160 5ht7r_human Human No 5.3 IC50 = 5623.4 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
418 7 0 5 4.7 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OC
CHEMBL495884 5ht7r_human Human No 6.3 IC50 = 567 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
477 7 1 4 4.3 O=S(=O)(NCCCN1CCN(c2ccc(C(F)(F)F)cc2)CC1)c1ccc2ccccc2c1
CHEMBL601872 5ht7r_human Human No 6.3 IC50 = 567 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
485 10 0 5 4.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1
CHEMBL4212812 5ht7r_human Human No 5.2 IC50 = 5790 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl
CHEMBL4302457 5ht7r_human Human No 5.2 IC50 = 5790 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assayAntagonist activity at human 5-HT7 receptor expressed in CHO-K1 cells assessed as decrease in serotonin-induced cAMP level after 1 hr by TR-FRET assay
344 6 0 3 4.2 Cc1cc(OCCCN2CCN(c3ccccc3)CC2)ccc1Cl
CHEMBL493402 5ht7r_human Human No 6.2 IC50 = 580 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
433 9 1 6 2.6 COc1ccc(S(=O)(=O)NC(C)CCN2CCN(c3ccccc3OC)CC2)cc1
CHEMBL3310123 5ht7r_human Human No 7.2 IC50 = 59 nM Funct
Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL3545474 5ht7r_human Human No 7.2 IC50 = 59 nM Funct
Inhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemInhibition of human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
281 1 3 2 1.3 CC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL260903 5ht7r_human Human No 6.2 IC50 = 590 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL261337 5ht7r_human Human No 6.2 IC50 = 590 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL260903 5ht7r_human Human No 6.2 IC50 = 590.2 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1C
CHEMBL261337 5ht7r_human Human No 6.2 IC50 = 590.2 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL3769441 5ht7r_human Human No 5.2 IC50 = 5943 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
456 7 2 6 1.8 COc1cccc(N2CCN(CC(O)CN3C(=O)NC(C)(c4ccc(F)cc4)C3=O)CC2)c1
CHEMBL602878 5ht7r_human Human No 8.2 IC50 = 6.3 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
532 9 0 5 4.9 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CC1
CHEMBL1852516 5ht7r_human Human No 8.2 IC50 = 6.8 nM Bind
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
471 6 1 5 4.3 Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1
CHEMBL3216758 5ht7r_human Human No 8.2 IC50 = 6.8 nM Bind
Inhibition of 5HT7 receptor by competition binding assayInhibition of 5HT7 receptor by competition binding assay
471 6 1 5 4.3 Cc1nc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c(C)n1-c1ccccc1
CHEMBL261433 5ht7r_human Human No 6.2 IC50 = 619.4 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL2392349 5ht7r_human Human No 7.2 IC50 = 62 nM Bind
Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor
443 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2Cc3ccc4ccccc4c3C2=O)CC1
CHEMBL1642117 5ht7r_human Human No 6.2 IC50 = 620 nM Bind
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
435 3 0 5 3.4 CN1CCN(c2cccc3c2C(=O)CCN3S(=O)(=O)c2ccc3ccccc3c2)CC1
CHEMBL261433 5ht7r_human Human No 6.2 IC50 = 620 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL3892079 5ht7r_human Human No 5.2 IC50 = 6309.6 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C
CHEMBL487805 5ht7r_human Human Yes 4.2 IC50 = 63400 nM Bind
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
462 4 7 11 -0.2 O=C(O)[C@H]1O[C@@H](Oc2cc3oc(-c4ccc(O)cc4)cc(=O)c3c(O)c2O)[C@H](O)[C@@H](O)[C@@H]1O
CHEMBL3892079 5ht7r_human Human No 5.2 IC50 = 6350 nM Funct
Antagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assayAntagonist activity at human 5-HT7R expressed in HEK293 cells assessed as inhibition of serotonin stimulated-cAMP levels preincubated for 10 mins followed by serotonin stimulation after 30 mins by D2-dye based fluorescence assay
402 6 0 4 5.0 COc1ccccc1-c1cc(CN2CCN(c3ccccc3OC)CC2)ccc1C
CHEMBL412153 5ht7r_human Human No 6.2 IC50 = 639.7 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL412153 5ht7r_human Human No 6.2 IC50 = 640 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
495 7 1 6 3.8 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL4434876 5ht7r_human Human No 6.2 IC50 = 650 nM Funct
Antagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysisAntagonist activity at 5HT7R receptor (unknown origin) assessed as forskolin-mediated cAMP accumulation preincubated for 30 mins followed by forskolin addition and measured after 30 mins by TR-FRET analysis
430 6 1 1 6.9 Fc1ccc(C2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2ccccc2)c1
CHEMBL260249 5ht7r_human Human No 6.2 IC50 = 650 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
481 8 1 6 3.6 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL260249 5ht7r_human Human No 6.2 IC50 = 650.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
481 8 1 6 3.6 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL603092 5ht7r_human Human No 6.2 IC50 = 657 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
423 7 1 4 3.7 CC(CCN1CCN(c2ccccc2)CC1)NS(=O)(=O)c1ccc2ccccc2c1
CHEMBL420863 5ht7r_human Human No 6.2 IC50 = 663 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
399 3 1 6 4.3 Cc1ccc2nc(O)n(C3CCN(Cc4cc5c(cc4Cl)OCO5)CC3)c2c1
CHEMBL601022 5ht7r_human Human No 6.2 IC50 = 678 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
553 10 0 5 5.5 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)CC2CCCCC2)cc1
CHEMBL259619 5ht7r_human Human No 6.2 IC50 = 680 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
485 7 1 6 3.4 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1
CHEMBL261018 5ht7r_human Human No 6.2 IC50 = 680 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL259619 5ht7r_human Human No 6.2 IC50 = 680.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
485 7 1 6 3.4 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1
CHEMBL261018 5ht7r_human Human No 6.2 IC50 = 680.8 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
541 9 1 7 3.9 CC(=O)c1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL522694 5ht7r_human Human Yes 6.2 IC50 = 681 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
409 7 1 4 3.3 O=S(=O)(NCCCN1CCN(c2ccccc2)CC1)c1ccc2ccccc2c1
CHEMBL2376490 5ht7r_human Human No 6.2 IC50 = 690 nM Bind
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
294 2 2 2 4.6 Cc1[nH]c2ccc(-c3ccsc3)cc2c1C1=CCNCC1
CHEMBL259414 5ht7r_human Human No 6.2 IC50 = 690 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL259414 5ht7r_human Human No 6.2 IC50 = 690.2 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
509 8 1 6 4.2 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL4209274 5ht7r_human Human Yes 5.2 IC50 = 6918.3 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
231 1 2 2 1.9 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)F
CHEMBL4209274 5ht7r_human Human Yes 5.2 IC50 = 6978 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
231 1 2 2 1.9 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)F
CHEMBL260023 5ht7r_human Human No 6.2 IC50 = 709.6 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
497 8 1 7 3.2 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL260023 5ht7r_human Human No 6.2 IC50 = 710 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
497 8 1 7 3.2 COc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL325516 5ht7r_human Human No 6.1 IC50 = 726 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
496 9 0 3 6.0 O=C(OCCc1ccc(F)cc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1
CHEMBL260250 5ht7r_human Human No 6.1 IC50 = 729.5 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
481 7 1 6 3.5 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL262589 5ht7r_human Human No 5.1 IC50 = 7294.6 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 8 1 8 3.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1
CHEMBL260906 5ht7r_human Human No 7.1 IC50 = 74.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL260250 5ht7r_human Human No 6.1 IC50 = 730 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
481 7 1 6 3.5 Cc1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL262589 5ht7r_human Human No 5.1 IC50 = 7300 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 8 1 8 3.3 O=C(CCN1CCN(c2ccc([N+](=O)[O-])cc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccc(F)cc1
CHEMBL260906 5ht7r_human Human No 7.1 IC50 = 74 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2ccc(F)cc2c(=O)n1-c1ccccc1
CHEMBL261102 5ht7r_human Human No 7.1 IC50 = 75.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL600607 5ht7r_human Human No 6.1 IC50 = 749 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
464 9 0 5 3.8 O=S(=O)(c1cccc2cccnc12)N(CCCN1CCN(c2ccccc2)CC1)CC1CC1
CHEMBL261102 5ht7r_human Human No 7.1 IC50 = 75 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1cccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL114379 5ht7r_human Human No 6.1 IC50 = 762 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
385 3 1 6 4.0 Oc1nc2ccccc2n1C1CCN(Cc2cc3c(cc2Cl)OCO3)CC1
CHEMBL260971 5ht7r_human Human No 6.1 IC50 = 769.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL261187 5ht7r_human Human No 6.1 IC50 = 769.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL260971 5ht7r_human Human No 6.1 IC50 = 770 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccc(F)cc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL261187 5ht7r_human Human No 6.1 IC50 = 770 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
517 8 1 6 3.9 O=C(CCCN1CCN(c2ccccc2F)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL4207884 5ht7r_human Human Yes 5.1 IC50 = 7762.5 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
247 1 2 2 2.4 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)Cl
CHEMBL4207884 5ht7r_human Human Yes 5.1 IC50 = 7788 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
247 1 2 2 2.4 C1CNCCC2=C1C(=NN2)C3=CC=C(C=C3)Cl
CHEMBL2312935 5ht7r_human Human No 5.1 IC50 = 7800 nM Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2c1
CHEMBL409156 5ht7r_human Human No 7.1 IC50 = 79 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
559 10 1 8 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL409156 5ht7r_human Human No 7.1 IC50 = 79.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
559 10 1 8 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3ccc(F)cc3c(=O)n2-c2ccccc2OC)CC1
CHEMBL259626 5ht7r_human Human No 7.1 IC50 = 80.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
497 8 1 7 3.2 COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL259626 5ht7r_human Human No 7.1 IC50 = 80 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
497 8 1 7 3.2 COc1ccccc1N1CCN(CCC(=O)NCc2nc3ccccc3c(=O)n2-c2ccccc2)CC1
CHEMBL3769534 5ht7r_human Human No 7.1 IC50 = 81 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
470 8 2 6 2.2 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1
CHEMBL2312640 5ht7r_human Human No 6.1 IC50 = 820 nM Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
492 8 1 5 4.4 O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cncc2ccccc12
CHEMBL260705 5ht7r_human Human No 7.1 IC50 = 84.9 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1
CHEMBL4215875 5ht7r_human Human No 6.1 IC50 = 844 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
228 1 1 3 2.3 CC1=CC=C(C=C1)C2=NOC3=C2CCNCC3
CHEMBL114484 5ht7r_human Human No 6.1 IC50 = 849 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
355 3 1 4 4.5 Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1
CHEMBL260705 5ht7r_human Human No 7.1 IC50 = 85 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
529 9 1 7 3.8 COc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2ccccc2)CC1
CHEMBL4215875 5ht7r_human Human No 6.1 IC50 = 851.1 nM Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of Gs protein-mediated cAMP accumulation by luminescence-based assay
228 1 1 3 2.3 CC1=CC=C(C=C1)C2=NOC3=C2CCNCC3
CHEMBL605582 5ht7r_human Human No 7.1 IC50 = 87 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
500 10 0 6 4.4 O=[N+]([O-])c1ccc(S(=O)(=O)N(CCCN2CCN(c3ccccc3)CC2)CC2CCCCC2)cc1
CHEMBL602087 5ht7r_human Human No 6.1 IC50 = 888 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
573 9 0 4 6.6 O=S(=O)(c1ccc2ccccc2c1)N(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)CC1CCCCC1
CHEMBL493625 5ht7r_human Human No 7.1 IC50 = 89 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
457 8 1 5 3.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3cccc(C(F)(F)F)c3)CC2)cc1
CHEMBL410922 5ht7r_human Human No 5.1 IC50 = 8995.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
509 8 1 7 3.4 CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL258995 5ht7r_human Human No 7.0 IC50 = 91.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1
CHEMBL410922 5ht7r_human Human No 5.1 IC50 = 9000 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
509 8 1 7 3.4 CC(=O)c1ccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)cc1
CHEMBL258995 5ht7r_human Human No 7.0 IC50 = 91 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
573 11 1 8 4.2 CCOc1ccccc1N1CCN(CCCC(=O)NCc2nc3cc(F)ccc3c(=O)n2-c2cccc(OC)c2)CC1
CHEMBL261019 5ht7r_human Human No 7.0 IC50 = 92 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL261019 5ht7r_human Human No 7.0 IC50 = 92.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
567 8 1 6 4.8 O=C(CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL410043 5ht7r_human Human No 6.0 IC50 = 920 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
529 9 1 7 3.8 COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL410043 5ht7r_human Human No 6.0 IC50 = 920.5 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
529 9 1 7 3.8 COc1cccc(N2CCN(CCCC(=O)NCc3nc4ccc(F)cc4c(=O)n3-c3ccccc3)CC2)c1
CHEMBL410075 5ht7r_human Human No 6.0 IC50 = 929.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL601859 5ht7r_human Human No 7.0 IC50 = 93 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
461 10 0 5 3.4 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CC2)cc1
CHEMBL410075 5ht7r_human Human No 6.0 IC50 = 930 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
499 8 1 6 3.7 O=C(CCCN1CCN(c2ccccc2)CC1)NCc1nc2cc(F)ccc2c(=O)n1-c1ccccc1
CHEMBL493811 5ht7r_human Human No 5.0 IC50 = 9314 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
419 9 1 6 2.2 COc1ccc(N2CCN(CCCNS(=O)(=O)c3ccc(OC)cc3)CC2)cc1
CHEMBL261099 5ht7r_human Human No 6.0 IC50 = 939.7 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL261654 5ht7r_human Human No 6.0 IC50 = 939.7 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
467 7 1 6 3.2 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL261099 5ht7r_human Human No 6.0 IC50 = 940 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
527 8 1 6 4.4 Cc1ccc(N2CCN(CCCC(=O)NCc3nc4cc(F)ccc4c(=O)n3-c3ccccc3)CC2)c(C)c1
CHEMBL261654 5ht7r_human Human No 6.0 IC50 = 940 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
467 7 1 6 3.2 O=C(CCN1CCN(c2ccccc2)CC1)NCc1nc2ccccc2c(=O)n1-c1ccccc1
CHEMBL492794 5ht7r_human Human No 6.0 IC50 = 949 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
373 8 1 4 2.2 O=S(=O)(NCCCN1CCN(Cc2ccccc2)CC1)c1ccccc1
CHEMBL261291 5ht7r_human Human No 7.0 IC50 = 95 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
495 7 1 6 3.8 Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL261291 5ht7r_human Human No 7.0 IC50 = 95.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
495 7 1 6 3.8 Cc1cccc(N2CCN(CCC(=O)NCc3nc4ccccc4c(=O)n3-c3ccccc3)CC2)c1C
CHEMBL258956 5ht7r_human Human No 7.0 IC50 = 97 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
541 10 1 8 3.6 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1
CHEMBL258956 5ht7r_human Human No 7.0 IC50 = 97.1 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
541 10 1 8 3.6 COc1ccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)cc1
CHEMBL407411 5ht7r_human Human No 7.0 IC50 = 98.0 nM Bind
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
541 10 1 8 3.6 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1
CHEMBL407411 5ht7r_human Human No 7.0 IC50 = 98 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
541 10 1 8 3.6 COc1cccc(-n2c(CNC(=O)CCCN3CCN(c4ccccc4OC)CC3)nc3ccccc3c2=O)c1
CHEMBL605787 5ht7r_human Human No 6.0 IC50 = 980 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
503 10 0 5 4.6 COc1ccc(S(=O)(=O)N(CCCN2CCN(c3ccc(F)cc3)CC2)CC2CCCCC2)cc1
CHEMBL194305 5ht7r_human Human Yes 5.0 IC50 = 9800 nM Bind
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
242 2 2 2 2.9 COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
CHEMBL116463 5ht7r_human Human No 6.0 IC50 = 998 nM Bind
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
517 10 1 4 6.2 N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1
CHEMBL2442996 5ht7r_human Human No 8.9 Kd = 1.2 nM Bind
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis
472 11 1 5 4.8 COc1ccc(-c2ccccc2N2CCN(CCCCCC(=O)NCc3ccncc3)CC2)cc1
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 8.0 Kd = 11.0 nM Funct
Antagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 4-(2-Diphenyl)-N-(4-pyridinylmethyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 7.9 Kd = 12.6 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-dimethylaminophenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 7.8 Kd = 14.5 nM Funct
Antagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid (1,2,3,4-tetrahydro-naphthalen-1-yl)-amide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 7.8 Kd = 14.5 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-(2-diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL222755 5ht7r_human Human No 7.8 Kd = 15.9 nM Bind
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
419 8 1 3 4.9 Cc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 7.8 Kd = 15.9 nM Funct
Antagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 2-[6-[4-(2-Diphenyl)-1-piperazinyl]-1-oxohexyl]-1,2,3,4-tetrahydroisoquinoline mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL225284 5ht7r_human Human Yes 7.7 Kd = 20.0 nM Bind
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL244161 5ht7r_cavpo Guinea pig No 7.7 Kd = 20.0 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction
434 9 2 4 4.6 CNc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 7.7 Kd = 20.4 nM Funct
Antagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL389718 5ht7r_human Human No 7.6 Kd = 25.1 nM Bind
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
447 9 1 4 4.8 CC(=O)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL39 5ht7r_human Human Yes 8.4 Kd = 4.0 nM Bind
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 8.4 Kd = 4.0 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-chlorophenyl)piperazine-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL18840 5ht7r_human Human Yes 7.5 Kd = 33.1 nM Bind
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 7.5 Kd = 33.1 nM Funct
Antagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAntagonist activity at 5HT7 receptor assessed as inhibition of 5-carboxamidotryptamine mediated relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 7.5 Kd = 33.1 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 3-(2-aminoethyl)-1H-indole-5-carboxamide mediated relaxation of substance P-induced contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 8.2 Kd = 6.3 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-(2-nitrophenyl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL225512 5ht7r_human Human No 7.2 Kd = 63.1 nM Bind
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
421 8 2 4 4.3 O=C(CCCCCN1CCN(c2ccccc2O)CC1)NC1CCCc2ccccc21
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 8.1 Kd = 7.9 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 6-(4-phenylpiperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide mediated relaxation of substance P-induced contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_cavpo Guinea pig Yes 8.1 Kd = 8.9 nM Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on 4-[2-(1-methylethyl)phenyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-piperazine hexanamide mediated relaxation of substance P-induced contraction
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL224820 5ht7r_human Human No 8.0 Kd = 9.6 nM Bind
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
435 9 1 4 4.6 COc1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL282199 5ht7r_human Human Yes 8.0 Kd = 9.7 nM Bind
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL18840 5ht7r_rat Rat Yes 10.5 Ki = 0.0 nM Bind
Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HTBinding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL3289972 5ht7r_human Human No 10.0 Ki = 0.1 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
466 8 1 6 3.5 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(F)c(Cl)c1
CHEMBL39 5ht7r_human Human Yes 10.0 Ki = 0.1 nM Bind
Binding affinity to human 5-HT7 receptor by radioligand displacement assayBinding affinity to human 5-HT7 receptor by radioligand displacement assay
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL18840 5ht7r_rat Rat Yes 9.9 Ki = 0.1 nM Bind
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL39 5ht7r_human Human Yes 9.9 Ki = 0.1 nM Bind
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL243954 5ht7r_rat Rat Yes 9.9 Ki = 0.1 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
481 9 1 3 6.2 O=C(NC1CCCc2c1cccc2)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL592752 5ht7r_human Human Yes 9.8 Ki = 0.2 nM Bind
Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)
304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1
CHEMBL39 5ht7r_human Human Yes 9.8 Ki = 0.2 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation countingDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL363452 5ht7r_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
351 8 2 4 4.9 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1
CHEMBL363452 5ht7r_human Human No 9.7 Ki = 0.2 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
351 8 2 4 4.9 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)c1)c1ccccc1
CHEMBL3290016 5ht7r_human Human No 9.7 Ki = 0.2 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
519 8 1 6 5.6 Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12
CHEMBL605405 5ht7r_human Human Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
302 2 0 2 4.6 Cc1ccc2c(c1)c1c(n2/C=C\c2ccccc2)CCN(C)C1
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
451 9 1 4 5.3 CSc1ccccc1N1CCN(CC1)CCCCCC(=O)NC1CCCc2c1cccc2
CHEMBL39 5ht7r_human Human Yes 9.7 Ki = 0.2 nM Bind
Displacement of radiolabeled serotonin from human 5HT7 receptorDisplacement of radiolabeled serotonin from human 5HT7 receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL611472 5ht7r_rat Rat No 9.6 Ki = 0.3 nM Bind
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
301 2 0 1 4.9 CN(C)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1
CHEMBL592752 5ht7r_human Human Yes 9.6 Ki = 0.3 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
304 3 0 2 4.2 Cc1ccc2c(c1)c1c(n2CCc2ccccc2)CCN(C)C1
CHEMBL4291322 5ht7r_human Human No 9.6 Ki = 0.3 nM Bind
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
399 5 1 2 5.3 Fc1ccc2[nH]cc(CCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1
CHEMBL182923 5ht7r_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
317 7 2 3 4.9 C[C@H](Nc1ccnc(NCCc2ccccc2)c1)c1ccccc1
CHEMBL183277 5ht7r_human Human No 9.5 Ki = 0.3 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
352 8 2 5 4.3 C[C@H](Nc1ccnc(NCCOc2ccc(F)cc2)n1)c1ccccc1
CHEMBL2159465 5ht7r_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
420 8 1 4 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2ccc(F)cc2)CC1
CHEMBL18840 5ht7r_human Human Yes 9.5 Ki = 0.3 nM Bind
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL596959 5ht7r_human Human No 9.5 Ki = 0.3 nM Bind
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
357 6 0 1 6.5 CCCN(CCC)[C@H]1CCc2c(cccc2-c2cccc3ccccc23)C1
CHEMBL414628 5ht7r_human Human No 9.5 Ki = 0.3 nM Bind
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)
499 4 1 5 2.5 COc1ccc(S(=O)(=O)N2CCc3ccc(I)cc32)cc1N1CCNCC1
CHEMBL282199 5ht7r_human Human Yes 9.5 Ki = 0.3 nM Bind
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.5 Ki = 0.3 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.5 Ki = 0.3 nM Bind
Displacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation countingDisplacement of [3H]D-lysergic acid diethylamide from 5HT7R (unknown origin) expressed in HEK293 cell membranes incubated for 1.5 hrs in absence of light by liquid scintillation counting
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.5 Ki = 0.3 nM Bind
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7 receptor (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.5 Ki = 0.3 nM Bind
Displacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting methodDisplacement of [3H]LSD from 5-HT7R (unknown origin) expressed in CHO-K1 cells by liquid scintillation counting method
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.5 Ki = 0.3 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting methodDisplacement of [3H]LSD from human 5-HT7 receptor expressed in HEK cell membranes after 1.5 hrs by microbeta scintillation counting method
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL18840 5ht7r_human Human Yes 9.5 Ki = 0.4 nM Bind
Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assayDisplacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells assessed as inhibitory constant incubated for 60 mins by radioligand binding assay
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL260994 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
411 7 1 3 4.9 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL605081 5ht7r_human Human Yes 9.4 Ki = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
318 3 0 2 4.5 Cc1ccc(CCn2c3c(c4cc(C)ccc42)CN(C)CC3)cc1
CHEMBL18840 5ht7r_human Human Yes 9.4 Ki = 0.4 nM Bind
Binding affinity against 5-hydroxytryptamine 7 human receptorsBinding affinity against 5-hydroxytryptamine 7 human receptors
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL181356 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
333 8 2 4 4.7 C[C@H](Nc1ccnc(NCCOc2ccccc2)c1)c1ccccc1
CHEMBL181605 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
335 7 2 3 5.0 C[C@H](Nc1ccnc(NCCc2ccc(F)cc2)c1)c1ccccc1
CHEMBL183423 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
351 8 2 4 4.9 C[C@H](Nc1cc(NCCOc2ccc(F)cc2)ccn1)c1ccccc1
CHEMBL184607 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
333 8 2 4 4.7 C[C@H](Nc1cc(NCCOc2ccccc2)ccn1)c1ccccc1
CHEMBL85 5ht7r_human Human Yes 9.4 Ki = 0.4 nM Bind
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL4245263 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
508 6 0 6 4.9 O=S(=O)(c1cncc2ccccc12)N1CCC[C@H]1CCN1CCC(c2noc3cc(F)ccc23)CC1
CHEMBL18840 5ht7r_human Human Yes 9.4 Ki = 0.4 nM Bind
Displacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 minsDisplacement of [3H]-5-CT from human recombinant 5-HT7 receptor expressed in CHO-K1 cells after 120 mins
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL408976 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
411 7 1 3 4.9 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL3290004 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
453 6 1 5 4.3 O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1
CHEMBL267062 5ht7r_human Human Yes 9.4 Ki = 0.4 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
387 4 1 2 4.4 O=C1c2ccccc2CCCN1CCN1CCC(c2c[nH]c3ccccc23)CC1
CHEMBL408976 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
411 7 1 3 4.9 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL260872 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
395 7 1 3 4.4 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL260872 5ht7r_human Human No 9.4 Ki = 0.4 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
395 7 1 3 4.4 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL3898250 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1
CHEMBL3991133 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1
CHEMBL4216782 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
273 4 1 4 2.5 Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1
CHEMBL4216782 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
273 4 1 4 2.5 Cc1nn(C)c(C)c1-c1ccc(O)c(CCN(C)C)c1
CHEMBL18840 5ht7r_human Human Yes 9.3 Ki = 0.5 nM Bind
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL261209 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1
CHEMBL261209 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
383 6 1 3 4.4 O=C1Nc2ccccc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1
CHEMBL1423 5ht7r_rat Rat Yes 9.3 Ki = 0.5 nM Bind
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
461 7 1 3 5.9 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2
CHEMBL1237021 5ht7r_human Human Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells incubated for 1 hr by liquid scintillation counting method
492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1
CHEMBL1237021 5ht7r_human Human Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrsDisplacement of [3H]-5-CT from human recombinant 5HT7b receptor measured after 2 hrs
492 5 0 6 4.3 O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1
CHEMBL3898250 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1
CHEMBL3991133 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
325 3 0 2 4.1 O=C1c2ccc(Cl)cc2CC1CCN1CCc2ccccc2C1
CHEMBL3290002 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
467 7 1 5 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12
CHEMBL18840 5ht7r_rat Rat Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL18840 5ht7r_rat Rat Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL413707 5ht7r_human Human No 9.3 Ki = 0.5 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
471 7 1 4 4.4 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(Oc2ccc(F)cc2)CC1
CHEMBL18840 5ht7r_rat Rat Yes 9.3 Ki = 0.5 nM Bind
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL18840 5ht7r_rat Rat Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL93240 5ht7r_human Human Yes 9.3 Ki = 0.5 nM Bind
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL4277476 5ht7r_human Human No 9.3 Ki = 0.6 nM Bind
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
449 6 1 2 6.0 Fc1cccc(-c2c(F)cccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1
CHEMBL9951 5ht7r_human Human No 9.3 Ki = 0.6 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
405 4 0 3 4.5 O=C1c2ccccc2CCCN1CCN1CCC(n2ccc3cc(F)ccc32)CC1
CHEMBL522691 5ht7r_rat Rat Yes 9.2 Ki = 0.6 nM Bind
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL522691 5ht7r_rat Rat Yes 9.2 Ki = 0.6 nM Bind
Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor
466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL522691 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL522691 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL522691 5ht7r_rat Rat Yes 9.2 Ki = 0.6 nM Bind
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL2164327 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C
CHEMBL161765 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1
CHEMBL185384 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
318 7 2 4 4.3 C[C@H](Nc1ccnc(NCCc2ccccc2)n1)c1ccccc1
CHEMBL2164327 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C
CHEMBL161765 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constantBinding affinity to 5HT7 receptor (unknown origin) assessed as inhibitory constant
258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1
CHEMBL2164327 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells
283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C
CHEMBL161765 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1
CHEMBL4065568 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
429 6 2 3 4.2 Cc1cccc(S(=O)(=O)NCCN2CC=C(c3c[nH]c4ccc(Cl)cc34)CC2)c1
CHEMBL3343666 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
309 3 2 2 2.4 CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL3545815 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
309 3 2 2 2.4 CCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL8618 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
393 7 0 5 2.9 COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2
CHEMBL161765 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor
258 5 0 3 3.4 CN(C)CCSc1cccc(-c2ccccc2)n1
CHEMBL259087 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL2164327 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor after 120 mins by scintillation counting analysis
283 2 0 3 3.1 CN([C@H]1CCc2c(C1)cccc2c1c(C)nn(c1C)C)C
CHEMBL3289991 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
431 7 1 5 3.8 Cc1cccc(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1
CHEMBL522691 5ht7r_human Human Yes 9.2 Ki = 0.6 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis
466 10 1 4 5.2 N#Cc1ccc(cc1)CNC(=O)CCCCCN1CCN(CC1)c1ccccc1c1ccccc1
CHEMBL406414 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(F)c(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL39 5ht7r_rat Rat Yes 9.2 Ki = 0.6 nM Bind
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL395444 5ht7r_rat Rat No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
694 18 0 9 5.9 COc1ccccc1N1CCN(CCc2cccc(OCCOCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1
CHEMBL259087 5ht7r_human Human No 9.2 Ki = 0.6 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL259086 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
425 7 1 3 5.2 CCC1(CCCCN2CCN(c3ccc(C)c(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL259549 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
429 7 1 3 5.1 CCC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2cc(F)ccc21
CHEMBL430706 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1
CHEMBL430706 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
476 6 2 3 5.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(c2c[nH]c3ccccc23)CC1
CHEMBL3321794 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1
CHEMBL158402 5ht7r_human Human Yes 9.2 Ki = 0.7 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
264 5 0 3 3.8 CN(C)CCSc1cccc(C2CCCCC2)n1
CHEMBL158402 5ht7r_human Human Yes 9.2 Ki = 0.7 nM Bind
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
264 5 0 3 3.8 CN(C)CCSc1cccc(C2CCCCC2)n1
CHEMBL3321794 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
346 6 0 2 4.0 O=C1Cc2ccccc2N1CC/C=C/CCN1CCc2ccccc2C1
CHEMBL3289970 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
482 8 1 6 4.0 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc(Cl)c(Cl)c1
CHEMBL3290017 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
535 8 1 6 6.1 Cc1c(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(Cl)cc12
CHEMBL115262 5ht7r_human Human No 9.2 Ki = 0.7 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
493 6 2 6 4.1 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@@H]1CCN1CCC(n2c(O)nc3ccccc32)CC1
CHEMBL282199 5ht7r_human Human Yes 9.2 Ki = 0.7 nM Bind
Displacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometryDisplacement of [3H]-5-HT from human 5-HT7 receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.2 Ki = 0.7 nM Bind
Displacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting methodDisplacement of [3H]-5-HT from recombinant human 5-HT7A receptor expressed in CHOK1 cell membranes after 40 mins by liquid scintillation counting method
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 9.2 Ki = 0.7 nM Bind
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysisDisplacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL4215605 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]-LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes measured after 60 mins by scintillation counting method
410 5 0 2 6.0 Clc1ccc(CCN2CCN(c3ccccc3-c3ccccc3)CC2)cc1Cl
CHEMBL3343667 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
325 4 2 3 1.6 COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL3545762 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
325 4 2 3 1.6 COCC1(OC)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL409662 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21
CHEMBL409662 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21
CHEMBL409662 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
429 7 1 3 5.1 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21
CHEMBL4285796 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
417 5 1 2 5.5 Fc1cccc(-c2ccccc2N2CCN(CCc3c[nH]c4ccc(F)cc34)CC2)c1
CHEMBL116292 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
499 7 1 4 5.0 O=C(c1ccc(Cl)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1
CHEMBL4591601 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
532 9 1 6 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4cccc(Cl)c4Cl)CC3)C2=O)cc1OC
CHEMBL39 5ht7r_human Human Yes 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL39 5ht7r_human Human Yes 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL3289978 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
464 8 1 6 3.9 O=S(=O)(NCCCCN1CCN(c2noc3ccccc23)CC1)c1ccc2ccccc2c1
CHEMBL3290003 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
481 8 1 5 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12
CHEMBL3290005 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
467 7 1 5 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1
CHEMBL492871 5ht7r_rat Rat No 9.1 Ki = 0.8 nM Bind
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
441 10 1 3 5.4 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccccc1
CHEMBL609675 5ht7r_rat Rat No 9.1 Ki = 0.8 nM Bind
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
282 2 1 1 4.0 Cc1[nH]c(C)c(-c2cccc3c2CC[C@H](N(C)C)C3)c1C
CHEMBL114345 5ht7r_human Human No 9.1 Ki = 0.8 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
483 7 1 4 4.4 O=C(c1ccc(F)cc1)C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1
CHEMBL4443201 5ht7r_human Human No 9.1 Ki = 0.9 nM Bind
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
368 6 1 5 3.1 O=c1[nH]c(CCCCN2CCN(c3ccccc3)CC2)nc2ccsc12
CHEMBL159022 5ht7r_rat Rat No 9.1 Ki = 0.9 nM Bind
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
407 9 0 6 4.4 COc1ccccc1C(=O)CCCCCN1CCN(c2noc3ccccc23)CC1
CHEMBL4544153 5ht7r_human Human No 9.1 Ki = 0.9 nM Bind
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
421 6 2 3 4.6 Fc1ccc(N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c(-c2cn[nH]c2)c1
CHEMBL18840 5ht7r_human Human Yes 9.1 Ki = 0.9 nM Bind
Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptor
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL93240 5ht7r_human Human Yes 9.1 Ki = 0.9 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL3289995 5ht7r_human Human No 9.1 Ki = 0.9 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
469 7 1 5 4.3 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(F)c(Cl)c1
CHEMBL3289999 5ht7r_human Human No 9.1 Ki = 0.9 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
423 7 1 6 3.6 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccs1
CHEMBL3290009 5ht7r_human Human No 9.1 Ki = 0.9 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
473 7 1 6 4.7 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1csc2ccccc12
CHEMBL243955 5ht7r_rat Rat No 9.1 Ki = 0.9 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
448 9 1 4 4.6 CN(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL239656 5ht7r_rat Rat No 9.1 Ki = 0.9 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
678 17 0 8 6.7 COc1ccccc1N1CCN(CCc2cccc(OCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1
CHEMBL18840 5ht7r_human Human Yes 9.0 Ki = 0.9 nM Bind
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL8165 5ht7r_rat Rat Yes 9.0 Ki = 0.9 nM Bind
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
190 3 2 2 1.7 NCCc1c[nH]c2c1cc(OC)cc2
CHEMBL494709 5ht7r_rat Rat No 9.0 Ki = 1.0 nM Bind
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
442 10 1 4 4.7 O=C(CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)NCc1ccncc1
CHEMBL4574299 5ht7r_human Human No 9.0 Ki = 1.0 nM Bind
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting methodDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHO cell membranes incubated for 120 mins by scintillation counting method
380 4 1 4 4.3 Fc1ccc2[nH]cc(CCN3CCN(c4nsc5ccccc45)CC3)c2c1
CHEMBL3331258 5ht7r_human Human No 9.0 Ki = 1.0 nM Bind
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
381 6 0 5 4.0 Cc1ccccc1N1CCN(CCCCn2c(=O)sc3ccccc32)CC1
CHEMBL182071 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
352 8 2 5 4.3 CC(Nc1nccc(NCCOc2ccc(F)cc2)n1)c1ccccc1
CHEMBL282199 5ht7r_human Human Yes 9.0 Ki = 1 nM Bind
Binding affinity to 5HT7 receptorBinding affinity to 5HT7 receptor
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL428892 5ht7r_rat Rat Yes 9.0 Ki = 1 nM Bind
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2
CHEMBL282199 5ht7r_human Human Yes 9.0 Ki = 1 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL28056 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
350 1 0 2 5.3 Cc1cccc(C#N)c1-c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3
CHEMBL282199 5ht7r_rat Rat Yes 9.0 Ki = 1 nM Bind
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL428892 5ht7r_rat Rat Yes 9.0 Ki = 1 nM Bind
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2
CHEMBL3759205 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
446 8 1 4 4.3 CC(C)c1cccc(OCCN2C3CCC2CC(NS(=O)(=O)c2ccc(F)cc2)C3)c1
CHEMBL4239091 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
507 6 0 7 4.2 O=S(=O)(c1cccc2cnccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1
CHEMBL4242858 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
507 6 0 7 4.2 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2nsc3ccccc23)CC1
CHEMBL4243848 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
506 6 0 6 4.8 O=S(=O)(c1cccc2ncccc12)N1CCC[C@@H]1CCN1CCN(c2cccc3sccc23)CC1
CHEMBL4647808 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Displacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting methodDisplacement of [3H]-5-carboxamidotryptamine from human 5-HT7A receptor expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting method
285 2 0 1 4.4 CN(C)[C@H]1CCc2c(cccc2-c2ccccc2Cl)C1
CHEMBL93240 5ht7r_human Human Yes 9.0 Ki = 1 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL4104622 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
431 6 3 4 3.6 O=S(=O)(NCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1cccc(O)c1
CHEMBL4465959 5ht7r_human Human No 9.0 Ki = 1 nM Bind
Displacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counterDisplacement of [3H]-LSD from human recombinant 5-HT7 receptor expressed in CHO cells incubated for 60 mins by microbeta2 scintillation counter
548 11 1 7 4.5 COc1ccc(/C=C2\NC(=O)N(CCCCN3CCN(c4ccccc4OC)CC3)C2=O)cc1OC1CCCC1
CHEMBL4442472 5ht7r_human Human Yes 9.0 Ki = 1 nM Bind
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
204 3 3 2 1.4 NCCc1c[nH]c2ccc(C(=O)O)cc12
CHEMBL85 5ht7r_human Human Yes 9.0 Ki = 1 nM Bind
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL258075 5ht7r_human Human Yes 9.0 Ki = 1 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
219 2 2 4 2.1 CC(C)Oc1cccc2c1N=C(N)NC2C
CHEMBL428892 5ht7r_human Human Yes 9.0 Ki = 1 nM Bind
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
356 2 0 4 4.4 CSc1ccc2c(c1)[C@@H](N1CCN(C)CC1)Cc1ccccc1S2
CHEMBL410226 5ht7r_human Human No 9.0 Ki = 1.0 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
408 7 1 2 5.9 CCC1(CCCCN2CC=C(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL154274 5ht7r_human Human No 9.0 Ki = 1.0 nM Bind
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)
503 5 2 5 3.4 COc1ccc(S(=O)(=O)Nc2cc(Br)ccc2Br)cc1N1CCNCC1
CHEMBL281923 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
CHEMBL281924 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor
291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
CHEMBL281923 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
CHEMBL281924 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
CHEMBL281924 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor expresssed in stable HEK cell membrane incubated for 90 mins by microbeta counting method
291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
CHEMBL281923 5ht7r_rat Rat No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
291 1 0 2 3.7 CO[C@@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
CHEMBL281924 5ht7r_rat Rat No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
291 1 0 2 3.7 CO[C@]1(C)c2cccc3c2-c2c1ccc1c2[C@@H](C3)N(C)CC1
CHEMBL269083 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
445 7 1 3 5.6 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccc(Cl)cc21
CHEMBL3289968 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
428 8 1 6 3.0 Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3noc4ccccc34)CC2)c1
CHEMBL3289990 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
417 6 1 5 3.4 Cc1cccc(S(=O)(=O)NCCN2CCC(c3noc4cc(F)ccc34)CC2)c1
CHEMBL243744 5ht7r_rat Rat No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
447 9 1 3 5.7 CC(C)c1ccccc1N1CCN(CCCCCC(=O)NC2CCCc3ccccc32)CC1
CHEMBL4278933 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
431 6 1 2 5.9 Fc1cccc(-c2ccccc2N2CCN(CCCc3c[nH]c4ccc(F)cc34)CC2)c1
CHEMBL4286174 5ht7r_human Human No 9.0 Ki = 1.1 nM Bind
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cell membranes after 120 mins by TopCount scintillation counting method
413 6 1 2 5.7 Fc1ccc2[nH]cc(CCCN3CCN(c4ccccc4-c4ccccc4)CC3)c2c1
CHEMBL410225 5ht7r_human Human No 8.9 Ki = 1.2 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
392 7 1 2 5.4 CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.2 nM Bind
Binding affinity to human cloned 5HT7 receptor expressed in HEK293 cellsBinding affinity to human cloned 5HT7 receptor expressed in HEK293 cells
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.2 nM Bind
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.2 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL3343663 5ht7r_human Human No 8.9 Ki = 1.2 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
295 2 3 2 1.7 CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL3545801 5ht7r_human Human No 8.9 Ki = 1.2 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
295 2 3 2 1.7 CCC1(O)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL410225 5ht7r_human Human No 8.9 Ki = 1.2 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
392 7 1 2 5.4 CCC1(CCCCN2CC=C(c3ccc(F)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL3289993 5ht7r_human Human No 8.9 Ki = 1.2 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
485 7 1 5 4.8 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc(Cl)c(Cl)c1
CHEMBL262068 5ht7r_human Human No 8.9 Ki = 1.2 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
425 8 1 3 5.3 CCC1(CCCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2ccccc21
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Binding affinity to 5HT7 receptor (unknown origin)Binding affinity to 5HT7 receptor (unknown origin)
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Binding affinity to human 5-HT7 receptor by radioligand binding assayBinding affinity to human 5-HT7 receptor by radioligand binding assay
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_rat Rat Yes 8.9 Ki = 1.3 nM Bind
Displacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from rat 5-hydroxytryptamine 7 receptor expressed in CHO cells
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL158973 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
161 3 0 2 2.1 CN(C)CCSC(C)(C)C
CHEMBL282199 5ht7r_human Human Yes 8.9 Ki = 1.3 nM Bind
Displacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7a receptor expressed in HEK293 cells
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL3343671 5ht7r_human Human No 8.9 Ki = 1.3 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
321 1 2 2 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2
CHEMBL3545813 5ht7r_human Human No 8.9 Ki = 1.3 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
321 1 2 2 2.2 NC(N)=NC(=O)c1ccc2c(c1)C1(CCOCC1)c1ccccc1-2
CHEMBL3290001 5ht7r_human Human No 8.9 Ki = 1.3 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
453 6 1 5 4.3 O=S(=O)(NCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2ccccc12
CHEMBL3290014 5ht7r_human Human No 8.9 Ki = 1.3 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
521 8 1 6 5.8 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccc(Cl)cc2s1
CHEMBL3290020 5ht7r_human Human No 8.9 Ki = 1.3 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
474 7 1 7 4.1 O=S(=O)(NCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cccc2scnc12
CHEMBL85 5ht7r_rat Rat Yes 8.9 Ki = 1.4 nM Bind
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL2164330 5ht7r_human Human Yes 8.9 Ki = 1.4 nM Bind
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
252 2 1 2 3.1 Cc1ccccc1-c1cccc(N2CCNCC2)c1
CHEMBL494675 5ht7r_human Human Yes 8.9 Ki = 1.4 nM Bind
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1
CHEMBL3343665 5ht7r_human Human No 8.9 Ki = 1.4 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
295 2 2 2 2.0 COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL3545814 5ht7r_human Human No 8.9 Ki = 1.4 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
295 2 2 2 2.0 COC1(C)c2ccccc2-c2ccc(C(=O)N=C(N)N)cc21
CHEMBL39 5ht7r_human Human Yes 8.9 Ki = 1.4 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL3290006 5ht7r_human Human No 8.9 Ki = 1.4 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
481 8 1 5 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1ccc2ccccc2c1
CHEMBL494675 5ht7r_human Human Yes 8.9 Ki = 1.4 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in cell membrane after 1.5 hrs by scintillation counting analysis
238 2 1 2 2.8 c1ccc(-c2ccccc2N2CCNCC2)cc1
CHEMBL4775997 5ht7r_human Human No 8.8 Ki = 1.4 nM Bind
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
437 7 1 5 3.6 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1ccc(F)c(Cl)c1
CHEMBL258496 5ht7r_human Human No 8.8 Ki = 1.5 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
425 8 1 3 5.3 CCC1(CCCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL3289952 5ht7r_human Human No 8.8 Ki = 1.5 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
452 6 1 6 3.6 O=S(=O)(NCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1
CHEMBL3289953 5ht7r_human Human No 8.8 Ki = 1.5 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
466 7 1 6 3.9 O=S(=O)(NCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1
CHEMBL3289992 5ht7r_human Human No 8.8 Ki = 1.5 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
445 8 1 5 4.2 Cc1cccc(S(=O)(=O)NCCCCN2CCC(c3noc4cc(F)ccc34)CC2)c1
CHEMBL259216 5ht7r_human Human No 8.8 Ki = 1.5 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
413 7 1 3 4.6 CCC1(CCCCN2CCN(c3ccc(F)cc3)CC2)C(=O)Nc2ccc(F)cc21
CHEMBL3958215 5ht7r_human Human No 8.8 Ki = 1.6 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
309 3 0 2 3.6 O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1
CHEMBL3958215 5ht7r_human Human No 8.8 Ki = 1.6 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting methodDisplacement of [3H]-LSD from human 5-HT7 receptor by liquid scintillation counting method
309 3 0 2 3.6 O=C1c2ccc(F)cc2CC1CCN1CCc2ccccc2C1
CHEMBL4204059 5ht7r_human Human No 8.8 Ki = 1.6 nM Bind
Displacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranesDisplacement of [3H]5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes
300 5 0 5 2.8 CCCCc1cc(-c2ccoc2)nc(N2CCN(C)CC2)n1
CHEMBL3289944 5ht7r_human Human No 8.8 Ki = 1.6 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
444 8 1 6 3.5 Cc1cccc(S(=O)(=O)NCCCCN2CCN(c3nsc4ccccc34)CC2)c1
CHEMBL3290012 5ht7r_human Human No 8.8 Ki = 1.6 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1
CHEMBL396844 5ht7r_rat Rat No 8.8 Ki = 1.6 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
706 19 0 8 7.5 COc1ccccc1N1CCN(CCc2cccc(OCCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1
CHEMBL9616 5ht7r_human Human No 8.8 Ki = 1.7 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
394 5 0 3 3.8 O=C(c1ccc(F)cc1)C1CCN(CCN2CCCc3ccccc3C2=O)CC1
CHEMBL4750664 5ht7r_human Human No 8.8 Ki = 1.7 nM Bind
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
399 7 1 5 3.1 Cc1cccc(S(=O)(=O)N[C@@H]2CCN(CCCc3noc4ccccc34)C2)c1
CHEMBL4754138 5ht7r_human Human No 8.8 Ki = 1.7 nM Bind
Displacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting methodDisplacement of [3H]-LSD from recombinant human 5HT7 receptor expressed in CHOK1 cell membranes measured after 120 mins by microbeta counting method
435 7 1 5 4.0 O=S(=O)(N[C@@H]1CCN(CCCc2noc3ccccc23)C1)c1cccc2ccccc12
CHEMBL3343670 5ht7r_human Human No 8.8 Ki = 1.7 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2
CHEMBL3545812 5ht7r_human Human No 8.8 Ki = 1.7 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
307 1 2 2 2.1 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCO1)c1ccccc1-2
CHEMBL3289709 5ht7r_human Human No 8.8 Ki = 1.7 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
430 7 1 6 3.1 Cc1cccc(S(=O)(=O)NCCCN2CCN(c3nsc4ccccc34)CC2)c1
CHEMBL93240 5ht7r_human Human Yes 8.8 Ki = 1.7 nM Bind
Displacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting methodDisplacement of [3H]LSD from recombinant human 5-HT7 receptor expressed in CHO cells cell membranes after 60 mins by liquid scintillation counting method
356 2 0 4 4.4 CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C
CHEMBL3331261 5ht7r_human Human No 8.8 Ki = 1.7 nM Bind
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
401 6 0 5 4.3 O=c1sc2ccccc2n1CCCCN1CCN(c2cccc(Cl)c2)CC1
CHEMBL184535 5ht7r_rat Rat No 8.8 Ki = 1.7 nM Bind
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
337 7 0 2 5.3 CCCN(CCC)[C@H]1CCc2c(cccc2-c2ccccc2OC)C1
CHEMBL396349 5ht7r_rat Rat No 8.8 Ki = 1.7 nM Bind
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
692 18 0 8 7.1 COc1ccccc1N1CCN(CCc2cccc(OCCCCCOc3cccc(CCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1
CHEMBL18840 5ht7r_rat Rat Yes 8.7 Ki = 1.8 nM Bind
Displacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 minsDisplacement of [3H]-5-CT from 5-HT7 receptor in Sprague-Dawley rat hypothalamus after 120 mins
203 3 3 2 0.8 NCCc1c[nH]c2c1cc(cc2)C(=O)N
CHEMBL3343669 5ht7r_human Human No 8.7 Ki = 1.8 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
305 1 2 1 2.9 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2
CHEMBL3545811 5ht7r_human Human No 8.7 Ki = 1.8 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in CHO cells
305 1 2 1 2.9 NC(N)=NC(=O)c1ccc2c(c1)C1(CCCC1)c1ccccc1-2
CHEMBL3289954 5ht7r_human Human No 8.7 Ki = 1.8 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
480 8 1 6 4.3 O=S(=O)(NCCCCN1CCN(c2nsc3ccccc23)CC1)c1ccc2ccccc2c1
CHEMBL408191 5ht7r_human Human No 8.7 Ki = 1.8 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
439 8 1 3 5.6 CC(C)CC1(CCCCN2CCN(c3cccc(Cl)c3)CC2)C(=O)Nc2ccccc21
CHEMBL323778 5ht7r_human Human No 8.7 Ki = 1.8 nM Bind
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
494 6 1 6 4.0 O=c1oc2ccccc2n1C1CCN(CC[C@H]2CCCN2S(=O)(=O)c2ccc3cc[nH]c3c2)CC1
CHEMBL4590226 5ht7r_human Human No 8.7 Ki = 1.9 nM Bind
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
386 8 2 5 2.8 NC(=O)c1sccc1NC(=O)CCCCN1CCN(c2ccccc2)CC1
CHEMBL428494 5ht7r_human Human No 8.7 Ki = 1.9 nM Bind
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3
CHEMBL428494 5ht7r_human Human No 8.7 Ki = 1.9 nM Bind
Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.Compound was evaluated for its ability to displace [3H]5-CT binding from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells.
390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3
CHEMBL2164334 5ht7r_human Human No 8.7 Ki = 1.9 nM Bind
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
266 2 1 2 3.4 Cc1ccc(-c2ccccc2N2CCNCC2)cc1C
CHEMBL282199 5ht7r_human Human Yes 8.7 Ki = 1.9 nM Bind
Displacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counterDisplacement of [3H]-5-HT from human 5HT7 receptor expressed in CHO-K1 cells incubated for 40 mins in presence of serotonin by liquid scintillation counter
352 5 1 4 2.7 CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
CHEMBL3290012 5ht7r_human Human No 8.7 Ki = 1.9 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells
487 8 1 6 5.1 O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1
CHEMBL408450 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
401 6 1 3 4.5 O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2cccc(Cl)c2)CC1
CHEMBL4521657 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Antagonist activity at 5-HT7 receptor (unknown origin)Antagonist activity at 5-HT7 receptor (unknown origin)
487 7 1 4 4.9 O=S(=O)(c1ccc2cc[nH]c2c1)N1CCC[C@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1
CHEMBL95104 5ht7r_rat Rat Yes 8.7 Ki = 2.0 nM Bind
Binding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligandBinding affinity for rat serotonin 5-HT7 receptor expressed in Sf9 cells using [3H]5-HT radioligand
487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2
CHEMBL362354 5ht7r_rat Rat No 8.7 Ki = 2.0 nM Bind
Inhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptorInhibition of [3H]-5-HT binding to rat 5-hydroxytryptamine 7 receptor
486 7 0 4 5.0 O=S(=O)(c1ccc2c(c1)CC=C2)N1CCC[C@@H]1CCN1CCC(Oc2ccc(Cl)cc2)CC1
CHEMBL116448 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
414 5 0 3 3.7 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1
CHEMBL69257 5ht7r_human Human Yes 8.7 Ki = 2.0 nM Bind
Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2
CHEMBL347286 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
414 5 0 3 3.7 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc(Br)c2)CC1
CHEMBL12846 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
388 6 1 2 5.3 O=C1Nc2cccc3c2C1(CCCCN1CCC(c2ccccc2)CC1)CCC3
CHEMBL428494 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3
CHEMBL69257 5ht7r_human Human Yes 8.7 Ki = 2.0 nM Bind
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
386 6 1 2 5.2 O=C1Nc2c3C1(CCCCN1CCC(=CC1)c1ccccc1)CCCc3ccc2
CHEMBL428494 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
390 6 1 4 3.6 O=C1Nc2cccc3c2C1(CCCCN1CCN(c2ccccn2)CC1)CCC3
CHEMBL157910 5ht7r_human Human No 8.7 Ki = 2.0 nM Bind
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)
449 5 2 5 3.9 COc1ccc(S(=O)(=O)Nc2cc(Cl)cc(Cl)c2Cl)cc1N1CCNCC1
CHEMBL95104 5ht7r_human Human Yes 8.7 Ki = 2.0 nM Bind
Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )Compound was tested for its binding affinity in 5-hydroxytryptamine 7 receptor (using human cloned receptors in HEK 293 and [3H]5-CT as a radioligand )
487 7 1 4 4.9 Clc1ccc(cc1)OC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1ccc2c(c1)[nH]cc2
CHEMBL3640556 5ht7r_rat Rat No 8.0 Ki = 10 nM Bind
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
339 5 1 4 3.6 COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1
CHEMBL441312 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
353 8 2 6 3.7 C[C@H](Nc1nc(F)nc(NCCOc2ccccc2)n1)c1ccccc1
CHEMBL85 5ht7r_human Human Yes 8.0 Ki = 10 nM Bind
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
CHEMBL274384 5ht7r_rat Rat Yes 8.0 Ki = 10 nM Bind
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC
CHEMBL332701 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@@H]2CCN2CCC(C)CC2)c1
CHEMBL94984 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine 7 receptor (a) (human cloned receptor) in HEK 293 cells using [3H]5-CT as radioligand.
386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1
CHEMBL153156 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
366 6 0 4 3.0 COc1cccc(S(=O)(=O)N2CCC[C@H]2CCN2CCC(C)CC2)c1
CHEMBL94261 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligandBinding affinity towards cloned human 5-hydroxytryptamine 7 receptor was determined in HEK293 cells using [3H]5-CT as radioligand
386 5 0 3 4.1 CC1CCN(CC[C@@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1
CHEMBL81607 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
331 3 0 3 3.9 Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1
CHEMBL94984 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1
CHEMBL81022 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
389 4 0 3 4.4 Brc1ccc2ccn(CCN3CCCN(C4CCCC4)CC3)c2c1
CHEMBL81607 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
331 3 0 3 3.9 Clc1ccc2ccn(CCN3CCCN4CCCCC4C3)c2c1
CHEMBL94984 5ht7r_rat Rat No 8.0 Ki = 10 nM Bind
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
386 5 0 3 4.1 CC1CCN(CC[C@H]2CCCN2S(=O)(=O)c2cccc3ccccc23)CC1
CHEMBL39 5ht7r_rat Rat Yes 8.0 Ki = 10 nM Bind
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
176 2 3 2 1.4 NCCc1c[nH]c2c1cc(O)cc2
CHEMBL309106 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Binding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligandBinding affinity towards recombinant human 5-hydroxytryptamine 7 receptor was determined using [3H]LSD as radioligand
585 10 2 8 3.3 CC(C)Oc1ccccc1N1CCN(C[C@@H](O)CNC(=O)c2ccc3c(c2)C(=O)N(c2ccc(N(C)C)cc2)C3=O)CC1
CHEMBL3640556 5ht7r_rat Rat No 8.0 Ki = 10 nM Bind
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
339 5 1 4 3.6 COc1ccc(-c2ccccc2OC(F)(F)F)cc1OC1CNC1
CHEMBL3769534 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cellsDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells
470 8 2 6 2.2 CCOc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(F)cc3)C2=O)CC1
CHEMBL3747240 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
494 10 0 6 4.0 Cn1cc(S(=O)(=O)N(CC2CC2)C2CCN(CCOc3ccccc3-c3ccccc3)CC2)cn1
CHEMBL3747459 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
420 8 0 6 2.7 CC(C)c1ccccc1OCCN1CCC(N(C)S(=O)(=O)c2cnn(C)c2)CC1
CHEMBL4243579 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
491 6 0 7 3.7 O=S(=O)(c1cccc2cnccc12)N1CCC[C@H]1CCN1CCN(c2noc3ccccc23)CC1
CHEMBL3941529 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
455 10 1 3 5.9 C[C@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1
CHEMBL2159471 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
428 8 1 5 3.8 O=S(=O)(NC1CCN(CCOc2ccccc2-c2ccccc2)C1)c1cccs1
CHEMBL2159477 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
439 8 1 5 3.8 CC(C)c1ccccc1OCCN1CCC(NS(=O)(=O)c2cccc3cccnc23)C1
CHEMBL2159492 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
440 8 1 4 3.9 O=S(=O)(N[C@H]1CCN(CCOc2ccccc2-c2ccccc2)C1)c1ccc(F)cc1
CHEMBL3409036 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
510 9 1 4 4.5 NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1
CHEMBL3409045 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
564 8 0 4 5.6 O=C([C@@H]1Cc2ccccc2CN1C(=O)CCCCN1CCN(c2ccccc2-c2ccccc2)CC1)N1CCCCC1
CHEMBL4170657 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
516 7 2 6 2.4 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1
CHEMBL4302436 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
516 7 2 6 2.4 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccc(Br)cc3)C2=O)CC1
CHEMBL4168743 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
438 7 2 6 1.6 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1
CHEMBL4302539 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting methodDisplacement of [3H]-5-CT from human 5HT7BR expressed in HEK293 cell membranes after 1 hr by Microbeta scintillation counting method
438 7 2 6 1.6 COc1ccccc1N1CCN(CC(O)CN2C(=O)NC(C)(c3ccccc3)C2=O)CC1
CHEMBL4077937 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation countingDisplacement of [3H]-LSD from human 5-HT7 receptor expressed in CHO-K1 cell membranes after 120 mins by scintillation counting
447 7 2 3 4.4 O=S(=O)(NCCCN1CC=C(c2c[nH]c3ccc(Cl)cc23)CC1)c1ccc(F)cc1
CHEMBL260551 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
463 7 1 3 5.7 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)c(Cl)cc21
CHEMBL3818056 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
295 5 1 3 3.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1
CHEMBL3289967 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
414 7 1 6 2.6 Cc1cccc(S(=O)(=O)NCCCN2CCN(c3noc4ccccc34)CC2)c1
CHEMBL3290015 5ht7r_human Human No 8.0 Ki = 10 nM Bind
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
505 7 1 6 5.2 Cc1c(S(=O)(=O)NCCCN2CCC(c3noc4cc(F)ccc34)CC2)sc2ccc(F)cc12
CHEMBL274384 5ht7r_human Human Yes 8.0 Ki = 10 nM Bind
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
401 3 1 2 3.7 CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)CC
CHEMBL3262411 5ht7r_human Human No 8.0 Ki = 10.1 nM Bind
Displacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysisDisplacement of [3H]5-HT from human 5-HT7 receptor expressed in HEK293 cells after 30 mins by microbeta counting analysis
311 6 2 4 3.0 Oc1cccc(NCCCN2CCN(c3ccccc3)CC2)c1
CHEMBL260870 5ht7r_human Human Yes 8.0 Ki = 10.1 nM Bind
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
479 7 1 3 6.2 CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2c(Cl)cc(Cl)cc21
CHEMBL273872 5ht7r_human Human No 8.0 Ki = 10.2 nM Bind
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
404 4 1 5 3.5 O=C1c2ccccc2CCCN1CCN1CCC(n2c(O)nc3ccccc32)CC1
CHEMBL3818056 5ht7r_human Human No 8.0 Ki = 10.2 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
295 5 1 3 3.4 O=C(CCCN1CCc2ccccc2C1)c1ccc(O)cc1
CHEMBL1112 5ht7r_human Human Yes 8.0 Ki = 10.3 nM Bind
Displacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation countingDisplacement of [3H]-LSD from human 5HT7 receptor by liquid scintillation counting
447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl
CHEMBL1112 5ht7r_human Human Yes 8.0 Ki = 10.3 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl
CHEMBL3331256 5ht7r_human Human No 8.0 Ki = 10.4 nM Bind
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
381 7 0 6 3.2 COc1ccccc1N1CCN(CCCCn2c(=O)oc3ccccc32)CC1
CHEMBL304167 5ht7r_human Human Yes 8.0 Ki = 10.5 nM Bind
Binding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligandBinding affinity to human recombinant 5-hydroxytryptamine 7 receptor in mammalian cells using [3H]5-CT as radioligand
403 6 1 3 4.5 Cc1ccccc1N1CCN(CCCCC23CCCc4cccc(c42)NC3=O)CC1
CHEMBL3640574 5ht7r_rat Rat No 8.0 Ki = 10.5 nM Bind
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
327 3 1 2 4.4 FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1
CHEMBL3640574 5ht7r_rat Rat No 8.0 Ki = 10.5 nM Bind
Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.Biological Assay: Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assay using 5-carboxamido[H3]typtamine ([3H]5-CT)(Amersham Biosciences) detection.
327 3 1 2 4.4 FC(F)(F)c1ccccc1-c1ccc(Cl)c(OC2CNC2)c1
CHEMBL3960056 5ht7r_human Human No 8.0 Ki = 10.5 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr by microbeta counting analysis
455 10 1 3 5.9 C[C@@H](NC(=O)CCCCCN1CCN(c2ccccc2-c2ccccc2)CC1)c1ccccc1
CHEMBL71 5ht7r_human Human Yes 8.0 Ki = 10.7 nM Bind
Displacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cellsDisplacement of [3H]-LSD from 5HT7 receptor (unknown origin) expressed in CHOK1 cells
318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C
CHEMBL3121435 5ht7r_human Human No 8.0 Ki = 10.8 nM Bind
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
397 5 0 4 5.0 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1
CHEMBL3139448 5ht7r_human Human No 8.0 Ki = 10.8 nM Bind
Displacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation countingDisplacement of [3H]-5-CT from cloned human 5HT7B receptor expressed in HEK293 cells after 1 hr by scintillation counting
397 5 0 4 5.0 COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)c3ccccc23)CC1
CHEMBL1836788 5ht7r_human Human No 8.0 Ki = 10.9 nM Bind
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
350 6 1 4 3.1 O=C1Nc2ccccc2C1CCCCN1CCN(c2ccccn2)CC1
CHEMBL273982 5ht7r_rat Rat No 7.0 Ki = 100 nM Bind
Binding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranesBinding affinity against 5-hydroxytryptamine 7 receptor using [3H]-5-CT in rat hypothalamus membranes
429 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1
CHEMBL1631535 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Binding affinity to human recombinant 5-HT7 receptor by radioligand displacement assayBinding affinity to human recombinant 5-HT7 receptor by radioligand displacement assay
424 6 1 5 3.3 Cc1ccc2c(N3CCN(CCc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1
CHEMBL1112 5ht7r_human Human Yes 7.0 Ki = 100 nM Bind
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
447 7 1 4 4.9 O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl
CHEMBL42 5ht7r_human Human Yes 7.0 Ki = 100 nM Bind
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2
CHEMBL273982 5ht7r_rat Rat No 7.0 Ki = 100 nM Bind
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
429 8 0 4 4.8 COc1ccccc1N1CCN(CCCCCN2C(=O)c3cccc4cccc2c34)CC1
CHEMBL162071 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
258 5 0 3 3.4 CN(C)CCSc1ccnc(-c2ccccc2)c1
CHEMBL268921 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor using [3H]5-CT as radioligand
361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3
CHEMBL268921 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligandBinding affinity towards human recombinant 5-hydroxytryptamine 7 receptor was determined using [3H]5-CT as radioligand
361 4 1 3 3.4 O=C1Nc2cccc3c2C1(CCN1CCN(c2ccccc2)CC1)CCC3
CHEMBL427518 5ht7r_rat Rat No 7.0 Ki = 100 nM Bind
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
419 9 1 6 2.2 COc1ccc(S(=O)(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1
CHEMBL6437 5ht7r_rat Rat Yes 7.0 Ki = 100 nM Bind
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
264 0 0 2 3.1 CN1CCN2C(C1)c1ccccc1Cc1c2cccc1
CHEMBL3746713 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells incubated for 1 hr
450 8 0 4 4.5 CN(C1CCN(CCOc2ccccc2-c2ccccc2)CC1)S(=O)(=O)c1ccccc1
CHEMBL4206366 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysisDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta scintillation counting analysis
376 4 1 4 2.4 O=C1Nc2ccccc2C12CCN(CCN1CCN(c3ccccc3)CC1)C2
CHEMBL4762886 5ht7r_rat Rat No 7.0 Ki = 100 nM Bind
Displacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assayDisplacement of [3H]-CT from rat 5-HT7 receptor expressed in HEK293 cells by competitive radioligand binding assay
271 2 1 3 2.7 Fc1ccc(-c2c3c(nn2C2CC2)CCNCC3)cc1
CHEMBL267930 5ht7r_human Human Yes 7.0 Ki = 100 nM Bind
Displacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cellsDisplacement of [3H]5-HT from recombinant human 5-HT7 receptor expressed in African green monkey COS7 cells
395 6 1 4 3.2 Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
CHEMBL240025 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
322 5 0 3 4.0 CC(=O)OC1CCc2ccc(/N=C/N(C)Cc3ccccc3)cc21
CHEMBL241103 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]5CT from 5HT7 receptor expressed in HEK293 cells
334 3 0 3 4.0 CC(=O)OC1CCc2ccc(/N=C/N3CCc4ccccc4C3)cc21
CHEMBL3104091 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)Displacement of [3H]LSD from 5-HT7 receptor (unknown origin)
288 0 0 2 3.7 CN1CCc2c(c3cccc4c3n2-c2ccccc2CC4)C1
CHEMBL126667 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
285 5 0 2 3.7 Fc1ccc(OCCCN2CCc3ccccc3C2)cc1
CHEMBL3819366 5ht7r_human Human No 7.0 Ki = 100 nM Bind
Displacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation countingDisplacement of [3H]LSD from human 5-HT7 receptor expressed in cell membranes after 1 hr by liquid scintillation counting
285 5 0 2 3.7 Fc1ccc(OCCCN2CCc3ccccc3C2)cc1
CHEMBL131495 5ht7r_human Human Yes 7.0 Ki = 100 nM Bind
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
417 6 1 3 4.5 O=C1c2ccccc2C(=O)N1CCCCN1CC=C(c2c[nH]c3ccc(F)cc23)CC1
CHEMBL285066 5ht7r_rat Rat Yes 7.0 Ki = 100.9 nM Bind
Binding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligandBinding affinity towards 5-HT 7 receptor in rat hypothalamus membranes using [3H]5-CT as radioligand
378 3 0 4 1.8 O=C1C2CCCN2C(=O)CN1CN1CCN(c2cccc3ccccc23)CC1
CHEMBL3640562 5ht7r_rat Rat No 6.0 Ki = 1000 nM Bind
Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.Binding Assay: Receptor binding was performed using membrane fractions prepared from the HEK-293 cell line recombinantly expressing rat 5-HT7 receptors (NCBI accession NM022938). Compound affinity for the rat 5-HT7 receptor subtype was evaluated by competitive radioligand binding assays using 5-carboxamido[3H]tryptamine ([3H]5-CT) (Amersham Biosciences, cat. 90000403) detection. HitHunter cAMP assays are in-vitro based competitive immunoassays. The assay was performed on the HEK-293 cell line stably transfected with r5-HT7 receptor. Cells were pre-incubated with test compounds for 10 minutes.
269 4 1 3 3.0 COc1ccc(-c2cccc(C)c2)cc1OC1CNC1
CHEMBL346191 5ht7r_human Human No 6.0 Ki = 1000 nM Bind
Binding affinity to 5HT7 (unknown origin)Binding affinity to 5HT7 (unknown origin)
421 6 0 4 4.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1
CHEMBL1729 5ht7r_human Human Yes 6.0 Ki = 1000 nM Bind
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N
CHEMBL560739 5ht7r_human Human Yes 6.0 Ki = 1000 nM Bind
Binding affinity to human serotonin 5-HT7 receptorBinding affinity to human serotonin 5-HT7 receptor
465 9 2 6 3.4 COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N
CHEMBL715 5ht7r_human Human Yes 6.0 Ki = 1000 nM Bind
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C
CHEMBL716 5ht7r_human Human Yes 6.0 Ki = 1000 nM Bind
Binding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assayBinding affinity to serotonin 5-HT7 receptor (unknown origin) by PDSP assay
383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2
CHEMBL346191 5ht7r_rat Rat No 6.0 Ki = 1000 nM Bind
Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.Binding affinity towards 5-hydroxytryptamine receptor 7 on rat hypothalamus membranes using [3H]5-CT as radioligand.
421 6 0 4 4.0 O=S1(=O)c2cccc3cccc(c23)N1CCCCN1CCN(c2ccccc2)CC1
CHEMBL1181680 5ht7r_human Human No 6.0 Ki = 1000 nM Bind
Binding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CTBinding affinity towards human 5-hydroxytryptamine receptor 7 expressed in HEK 293 cells using the radioligand [3H]5-CT
517 13 1 3 6.3 CN(C)CCN(Cc1ccc(-c2ccc(CNCCc3ccccc3)cc2)cc1)C(=O)/C=C/c1ccccc1
CHEMBL188486 5ht7r_human Human No 6.0 Ki = 1000 nM Bind