Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Unit Assay Type Assay Description Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles
CHEMBL225571 5ht7r_cavpo Guinea pig No 5.0 EC50 = 10000 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
451 8 1 5 4.3 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4[N+](=O)[O-]
CHEMBL225571 5ht7r_cavpo Guinea pig No 5.0 EC50 = 10000 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
451 8 1 5 4.3 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4[N+](=O)[O-]
CHEMBL243955 5ht7r_cavpo Guinea pig No 5.9 EC50 = 1170 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
449 9 1 4 4.6 CN(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL243955 5ht7r_cavpo Guinea pig No 5.9 EC50 = 1170 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
449 9 1 4 4.6 CN(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL222477 5ht7r_cavpo Guinea pig No 4.8 EC50 = 17000 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
440 8 1 3 5.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4Cl
CHEMBL222477 5ht7r_cavpo Guinea pig No 4.8 EC50 = 17000 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
440 8 1 3 5.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4Cl
CHEMBL243954 5ht7r_cavpo Guinea pig Yes 5.8 EC50 = 1770 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
482 9 1 3 6.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL243954 5ht7r_cavpo Guinea pig Yes 5.8 EC50 = 1770 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
482 9 1 3 6.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL222755 5ht7r_human Human No 5.7 EC50 = 1820 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
420 8 1 3 4.8 CC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL222755 5ht7r_human Human No 5.7 EC50 = 1820 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
420 8 1 3 4.8 CC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL3321794 5ht7r_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
346 6 0 2 3.8 C1CN(CC2=CC=CC=C21)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL3321794 5ht7r_human Human No 6.6 EC50 = 230 Funct
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
346 6 0 2 3.8 C1CN(CC2=CC=CC=C21)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL389718 5ht7r_human Human No 5.6 EC50 = 2460 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
448 9 1 4 4.1 CC(=O)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL389718 5ht7r_human Human No 5.6 EC50 = 2460 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
448 9 1 4 4.1 CC(=O)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 5.6 EC50 = 2560 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 5.6 EC50 = 2560 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL494709 5ht7r_cavpo Guinea pig No 6.5 EC50 = 310 Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
443 10 1 4 4.2 C1CN(CCN1CCCCCC(=O)NCC2=CC=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL445334 5ht7r_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
320 5 0 2 3.2 C1CN(CC2=CC=CC=C21)CCCCN3C(=O)CC4=CC=CC=C43
CHEMBL494709 5ht7r_cavpo Guinea pig No 6.5 EC50 = 310 Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
443 10 1 4 4.2 C1CN(CCN1CCCCCC(=O)NCC2=CC=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL445334 5ht7r_human Human No 6.5 EC50 = 310 Funct
Agonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assayAgonist activity at human recombinant 5HT7 receptor expressed in CHOK1 cells assessed as increase in cAMP levels by HTRF assay
320 5 0 2 3.2 C1CN(CC2=CC=CC=C21)CCCCN3C(=O)CC4=CC=CC=C43
CHEMBL492480 5ht7r_cavpo Guinea pig No 6.3 EC50 = 490 Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
468 8 0 3 5.5 C1CN(CC2=CC=CC=C21)C(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL492480 5ht7r_cavpo Guinea pig No 6.3 EC50 = 490 Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
468 8 0 3 5.5 C1CN(CC2=CC=CC=C21)C(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL371300 5ht7r_human Human Yes 5.3 EC50 = 5600 Funct
Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL371300 5ht7r_human Human Yes 5.3 EC50 = 5600 Funct
Activity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assayActivity at 5HT7 receptor expressed in human corneal epithelial CEPI-17-CL4 cells by adenylyl cyclase assay
191 2 2 4 0.1 CC(CN1C2=CC(=O)C=CC2=CN1)N
CHEMBL3321798 5ht7r_human Human No 7.2 EC50 = 60 Funct
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
353 6 0 2 4.6 C1CCC2CN(CCC2C1)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL3321798 5ht7r_human Human No 7.2 EC50 = 60 Funct
Agonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assayAgonist activity at human 5-HT7 expressed in HEK-293 cells assessed as increase in cAMP level after 45 mins by HTRF assay
353 6 0 2 4.6 C1CCC2CN(CCC2C1)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL522691 5ht7r_cavpo Guinea pig Yes 6.2 EC50 = 600 Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_cavpo Guinea pig Yes 6.2 EC50 = 600 Funct
Agonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contractionAgonist activity at 5HT7 receptor assessed as relaxation of substance P-induced Dunkin-Hartley guinea pig ileum contraction
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL224820 5ht7r_human Human No 5.2 EC50 = 6320 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
436 9 1 4 4.4 COC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL224820 5ht7r_human Human No 5.2 EC50 = 6320 Funct
Activity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at 5HT7 receptor assessed as relaxation of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
436 9 1 4 4.4 COC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL222188 5ht7r_cavpo Guinea pig No 5.1 EC50 = 8000 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
406 8 1 3 4.5 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4
CHEMBL222188 5ht7r_cavpo Guinea pig No 5.1 EC50 = 8000 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
406 8 1 3 4.5 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4
CHEMBL243744 5ht7r_cavpo Guinea pig No 6.1 EC50 = 900 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
448 9 1 3 5.6 CC(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL243744 5ht7r_cavpo Guinea pig No 6.1 EC50 = 900 Funct
Agonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contractionAgonist activity at 5HT7 receptor in guinea pig ileum assessed as relaxation of substance P-induced contraction
448 9 1 3 5.6 CC(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL1278088 5ht7r_human Human Yes 6.0 IC50 = 1000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
433 6 1 6 2.8 C1CCC2=C(C1)C(=O)N(C(=N2)CCCCN3CCN(CC3)C4=NC5=CC=CC=C5C=C4)N
CHEMBL411442 5ht7r_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL411442 5ht7r_human Human No 6.0 IC50 = 1000 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL1278088 5ht7r_human Human Yes 6.0 IC50 = 1000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
433 6 1 6 2.8 C1CCC2=C(C1)C(=O)N(C(=N2)CCCCN3CCN(CC3)C4=NC5=CC=CC=C5C=C4)N
CHEMBL411442 5ht7r_human Human No 6.0 IC50 = 1000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL411442 5ht7r_human Human No 6.0 IC50 = 1000 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL1222138 5ht7r_human Human No 6.0 IC50 = 1006 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
374 5 0 5 3.4 CC(C)N(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC=CC=C3
CHEMBL1222138 5ht7r_human Human No 6.0 IC50 = 1006 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
374 5 0 5 3.4 CC(C)N(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC=CC=C3
CHEMBL3769612 5ht7r_human Human No 6.0 IC50 = 1011 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
455 6 2 6 2.9 CC1=CC(=C(C=C1)C)N2CCN(CC2)CC(CN3C(=O)C(NC3=O)(C)C4=CC=C(C=C4)F)O
CHEMBL3769612 5ht7r_human Human No 6.0 IC50 = 1011 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
455 6 2 6 2.9 CC1=CC(=C(C=C1)C)N2CCN(CC2)CC(CN3C(=O)C(NC3=O)(C)C4=CC=C(C=C4)F)O
CHEMBL492793 5ht7r_human Human No 7.0 IC50 = 103 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
458 8 1 6 4.1 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC(=C(C=C3)Cl)Cl
CHEMBL492793 5ht7r_human Human No 7.0 IC50 = 103 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
458 8 1 6 4.1 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC(=C(C=C3)Cl)Cl
CHEMBL495250 5ht7r_human Human No 7.0 IC50 = 107 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
472 8 1 9 4.2 CC(CCN1CCN(CC1)C2=CC=CC(=C2)C(F)(F)F)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL495250 5ht7r_human Human No 7.0 IC50 = 107 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
472 8 1 9 4.2 CC(CCN1CCN(CC1)C2=CC=CC(=C2)C(F)(F)F)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL260073 5ht7r_human Human No 7.0 IC50 = 109.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL260514 5ht7r_human Human No 7.0 IC50 = 109.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL260073 5ht7r_human Human No 7.0 IC50 = 109.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL260514 5ht7r_human Human No 7.0 IC50 = 109.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL260901 5ht7r_human Human No 6.0 IC50 = 1099.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
496 7 1 5 4.1 CC1=C(C=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL411868 5ht7r_human Human No 6.0 IC50 = 1099.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260901 5ht7r_human Human No 6.0 IC50 = 1099.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
496 7 1 5 4.1 CC1=C(C=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL411868 5ht7r_human Human No 6.0 IC50 = 1099.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260907 5ht7r_human Human No 7.9 IC50 = 12.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260907 5ht7r_human Human No 7.9 IC50 = 12.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260073 5ht7r_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL260514 5ht7r_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL601659 5ht7r_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
474 9 0 6 5.5 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)F
CHEMBL260073 5ht7r_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL260514 5ht7r_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL601659 5ht7r_human Human No 7.0 IC50 = 110 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
474 9 0 6 5.5 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)F
CHEMBL260901 5ht7r_human Human No 6.0 IC50 = 1100 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
496 7 1 5 4.1 CC1=C(C=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL411868 5ht7r_human Human No 6.0 IC50 = 1100 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260901 5ht7r_human Human No 6.0 IC50 = 1100 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
496 7 1 5 4.1 CC1=C(C=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL411868 5ht7r_human Human No 6.0 IC50 = 1100 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL602060 5ht7r_human Human No 6.9 IC50 = 117 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
464 9 0 5 5.1 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL602060 5ht7r_human Human No 6.9 IC50 = 117 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
464 9 0 5 5.1 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL116735 5ht7r_human Human No 5.9 IC50 = 1170 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
481 9 0 5 5.8 C1CN(CCN1CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CCC4=CC=C(C=C4)F
CHEMBL259776 5ht7r_human Human No 6.9 IC50 = 120.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259776 5ht7r_human Human No 6.9 IC50 = 120.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260969 5ht7r_human Human No 5.9 IC50 = 1199.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL260969 5ht7r_human Human No 5.9 IC50 = 1199.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL260907 5ht7r_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL495678 5ht7r_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
478 7 1 8 5.0 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=CC(=C4)C(F)(F)F
CHEMBL260907 5ht7r_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL495678 5ht7r_human Human No 7.9 IC50 = 12 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
478 7 1 8 5.0 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=CC(=C4)C(F)(F)F
CHEMBL602677 5ht7r_human Human No 7.9 IC50 = 12.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
495 10 0 7 4.0 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CC3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL602677 5ht7r_human Human No 7.9 IC50 = 12.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
495 10 0 7 4.0 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CC3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL259776 5ht7r_human Human No 6.9 IC50 = 120 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259776 5ht7r_human Human No 6.9 IC50 = 120 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260969 5ht7r_human Human No 5.9 IC50 = 1200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL260969 5ht7r_human Human No 5.9 IC50 = 1200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL601249 5ht7r_human Human No 6.9 IC50 = 121 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
444 10 0 6 3.8 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3)CC4CC4
CHEMBL601249 5ht7r_human Human No 6.9 IC50 = 121 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
444 10 0 6 3.8 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3)CC4CC4
CHEMBL584046 5ht7r_human Human No 5.9 IC50 = 1217 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
364 5 0 4 2.7 CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC(=CC=C3)Cl
CHEMBL584046 5ht7r_human Human No 5.9 IC50 = 1217 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
364 5 0 4 2.7 CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC(=CC=C3)Cl
CHEMBL600012 5ht7r_human Human No 5.9 IC50 = 1236 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
506 9 0 5 6.7 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL600012 5ht7r_human Human No 5.9 IC50 = 1236 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
506 9 0 5 6.7 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL495212 5ht7r_human Human No 6.9 IC50 = 124 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
478 7 1 5 5.4 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC(=C(C=C4)Cl)Cl
CHEMBL601855 5ht7r_human Human No 6.9 IC50 = 124 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
512 10 0 9 4.7 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)CC4CC4
CHEMBL495212 5ht7r_human Human No 6.9 IC50 = 124 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
478 7 1 5 5.4 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC(=C(C=C4)Cl)Cl
CHEMBL601855 5ht7r_human Human No 6.9 IC50 = 124 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
512 10 0 9 4.7 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)CC4CC4
CHEMBL260074 5ht7r_human Human No 6.9 IC50 = 130 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL260970 5ht7r_human Human No 6.9 IC50 = 130 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL260074 5ht7r_human Human No 6.9 IC50 = 130 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL260970 5ht7r_human Human No 6.9 IC50 = 130 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL260074 5ht7r_human Human No 6.9 IC50 = 130.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL260970 5ht7r_human Human No 6.9 IC50 = 130.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL260074 5ht7r_human Human No 6.9 IC50 = 130.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL260970 5ht7r_human Human No 6.9 IC50 = 130.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL258524 5ht7r_human Human No 5.9 IC50 = 1300 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL258524 5ht7r_human Human No 5.9 IC50 = 1300 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL258524 5ht7r_human Human No 5.9 IC50 = 1300.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL258524 5ht7r_human Human No 5.9 IC50 = 1300.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL565745 5ht7r_human Human No 5.9 IC50 = 1362 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
336 4 1 4 1.7 C1=CC(=CC(=C1)Cl)S(=O)(=O)C2=CN(C3=C2C=CC=N3)CCN
CHEMBL565745 5ht7r_human Human No 5.9 IC50 = 1362 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
336 4 1 4 1.7 C1=CC(=CC(=C1)Cl)S(=O)(=O)C2=CN(C3=C2C=CC=N3)CCN
CHEMBL3771309 5ht7r_human Human No 5.9 IC50 = 1388 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
495 6 2 6 3.4 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)O)C4=CC=C(C=C4)F
CHEMBL3771309 5ht7r_human Human No 5.9 IC50 = 1388 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
495 6 2 6 3.4 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl)O)C4=CC=C(C=C4)F
CHEMBL259625 5ht7r_human Human No 5.9 IC50 = 1399.6 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
498 8 1 6 3.3 COC1=CC=CC(=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL259625 5ht7r_human Human No 5.9 IC50 = 1399.6 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
498 8 1 6 3.3 COC1=CC=CC(=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL494428 5ht7r_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
428 7 1 6 4.2 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=CC=C4F
CHEMBL494428 5ht7r_human Human No 6.9 IC50 = 140 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
428 7 1 6 4.2 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=CC=C4F
CHEMBL259625 5ht7r_human Human No 5.9 IC50 = 1400 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
498 8 1 6 3.3 COC1=CC=CC(=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL259625 5ht7r_human Human No 5.9 IC50 = 1400 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
498 8 1 6 3.3 COC1=CC=CC(=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL1642116 5ht7r_human Human No 6.8 IC50 = 143 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
436 3 0 6 3.3 CN1CCN(CC1)C2=CC3=C(C=C2)C(=O)CCN3S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL21343 5ht7r_human Human Yes 6.8 IC50 = 143 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
309 3 2 2 2.5 CCN(CC)C(=O)C1CNC2CC3=CNC4=CC=CC(=C34)C2=C1
CHEMBL1642116 5ht7r_human Human No 6.9 IC50 = 143 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
436 3 0 6 3.3 CN1CCN(CC1)C2=CC3=C(C=C2)C(=O)CCN3S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL21343 5ht7r_human Human Yes 6.9 IC50 = 143 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
309 3 2 2 2.5 CCN(CC)C(=O)C1CNC2CC3=CNC4=CC=CC(=C34)C2=C1
CHEMBL115249 5ht7r_human Human No 5.9 IC50 = 1430 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
397 10 0 4 4.5 CCOC1=CC=C(C=C1)CCOC(=O)N2CCN(CC2)CCCC3=CC=CC=C3
CHEMBL326263 5ht7r_human Human No 5.8 IC50 = 1440 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
504 10 0 6 5.9 C1CN(CCN1CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)OCCC4=CC=C(C=C4)C#N
CHEMBL601673 5ht7r_human Human No 6.8 IC50 = 147 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
432 9 0 6 3.9 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)F
CHEMBL601673 5ht7r_human Human No 6.8 IC50 = 147 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
432 9 0 6 3.9 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)F
CHEMBL410722 5ht7r_human Human No 5.8 IC50 = 1499.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL410722 5ht7r_human Human No 5.8 IC50 = 1499.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL3343672 5ht7r_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.2 C1CC2(C3=CC=CC=C3C4=C2C=C(C=C4)C(=O)N=C(N)N)OC1
CHEMBL3343672 5ht7r_human Human No 7.8 IC50 = 15 Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.2 C1CC2(C3=CC=CC=C3C4=C2C=C(C=C4)C(=O)N=C(N)N)OC1
CHEMBL410722 5ht7r_human Human No 5.8 IC50 = 1500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL267615 5ht7r_human Human Yes 5.8 IC50 = 1500 Funct
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
246 5 1 2 3.2 CCC1=C(C2=C(N1)C=CC(=C2)OC)CCN(C)C
CHEMBL410722 5ht7r_human Human No 5.8 IC50 = 1500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL267615 5ht7r_human Human Yes 5.8 IC50 = 1500 Funct
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
246 5 1 2 3.2 CCC1=C(C2=C(N1)C=CC(=C2)OC)CCN(C)C
CHEMBL602284 5ht7r_human Human No 5.8 IC50 = 1508 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
524 9 0 6 6.8 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL602284 5ht7r_human Human No 5.8 IC50 = 1508 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
524 9 0 6 6.8 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL601457 5ht7r_human Human No 6.8 IC50 = 152 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
464 9 0 5 5.1 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL601457 5ht7r_human Human No 6.8 IC50 = 152 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
464 9 0 5 5.1 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL1221497 5ht7r_human Human No 5.8 IC50 = 1582 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
381 4 1 5 3.6 CN1CCN(CC1)C2=CC(=CC=C2)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL1221497 5ht7r_human Human No 5.8 IC50 = 1582 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
381 4 1 5 3.6 CN1CCN(CC1)C2=CC(=CC=C2)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL260706 5ht7r_human Human No 6.8 IC50 = 160.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
550 8 1 5 5.0 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL260706 5ht7r_human Human No 6.8 IC50 = 160.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
550 8 1 5 5.0 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL261742 5ht7r_human Human No 7.8 IC50 = 16 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL406221 5ht7r_human Human No 7.8 IC50 = 16 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL261742 5ht7r_human Human No 7.8 IC50 = 16 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL406221 5ht7r_human Human No 7.8 IC50 = 16 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL261742 5ht7r_human Human No 7.8 IC50 = 16 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL406221 5ht7r_human Human No 7.8 IC50 = 16 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL261742 5ht7r_human Human No 7.8 IC50 = 16 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL406221 5ht7r_human Human No 7.8 IC50 = 16 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL260706 5ht7r_human Human No 6.8 IC50 = 160 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
550 8 1 5 5.0 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL601886 5ht7r_human Human No 6.8 IC50 = 160 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
575 9 0 9 6.6 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL260706 5ht7r_human Human No 6.8 IC50 = 160 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
550 8 1 5 5.0 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL601886 5ht7r_human Human No 6.8 IC50 = 160 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
575 9 0 9 6.6 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL595449 5ht7r_human Human No 5.8 IC50 = 1713 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
350 5 1 4 4.5 CC(C)(C)C1=CC=C(C=C1)C2=NC(=NN2C3=CC(=CC=C3)O)CN(C)C
CHEMBL595449 5ht7r_human Human No 5.8 IC50 = 1713 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
350 5 1 4 4.5 CC(C)(C)C1=CC=C(C=C1)C2=NC(=NN2C3=CC(=CC=C3)O)CN(C)C
CHEMBL600822 5ht7r_human Human No 6.8 IC50 = 172 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
516 11 0 7 5.4 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3OC)CC4CCCCC4
CHEMBL600822 5ht7r_human Human No 6.8 IC50 = 172 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
516 11 0 7 5.4 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3OC)CC4CCCCC4
CHEMBL81485 5ht7r_human Human No 7.7 IC50 = 18.6 Funct
Binding affinity for human cloned 5-hydroxytryptamine 7 receptorBinding affinity for human cloned 5-hydroxytryptamine 7 receptor
280 2 1 3 3.4 CNCC1CC2C3=CC=CC=C3CC4=CC=CC=C4N2O1
CHEMBL2376484 5ht7r_human Human No 5.8 IC50 = 1800 Funct
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
360 3 2 7 2.9 CC1=C(C2=C(N1)C=CC(=C2)OS(=O)(=O)C(F)(F)F)C3=CCNCC3
CHEMBL3771222 5ht7r_human Human No 5.7 IC50 = 1807 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
517 8 2 6 3.5 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)O)C5=CC=C(C=C5)F
CHEMBL3771222 5ht7r_human Human No 5.7 IC50 = 1807 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
517 8 2 6 3.5 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)O)C5=CC=C(C=C5)F
CHEMBL603272 5ht7r_human Human No 6.7 IC50 = 188 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
494 10 0 6 5.0 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CC3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL603272 5ht7r_human Human No 6.7 IC50 = 188 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
494 10 0 6 5.0 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CC3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL258785 5ht7r_human Human No 7.7 IC50 = 19 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL258785 5ht7r_human Human No 7.7 IC50 = 19 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL258785 5ht7r_human Human No 7.7 IC50 = 19.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL258785 5ht7r_human Human No 7.7 IC50 = 19.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
544 10 1 7 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259407 5ht7r_human Human No 6.7 IC50 = 190 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
560 10 1 8 3.7 COC1=CC=C(C=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL411105 5ht7r_human Human No 6.7 IC50 = 190 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL259407 5ht7r_human Human No 6.7 IC50 = 190 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
560 10 1 8 3.7 COC1=CC=C(C=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL411105 5ht7r_human Human No 6.7 IC50 = 190 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL259407 5ht7r_human Human No 6.7 IC50 = 190.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
560 10 1 8 3.7 COC1=CC=C(C=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL411105 5ht7r_human Human No 6.7 IC50 = 190.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL259407 5ht7r_human Human No 6.7 IC50 = 190.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
560 10 1 8 3.7 COC1=CC=C(C=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL411105 5ht7r_human Human No 6.7 IC50 = 190.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=CC=C5)Cl
CHEMBL602882 5ht7r_human Human No 6.7 IC50 = 195 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
506 9 0 5 6.7 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL602882 5ht7r_human Human No 6.7 IC50 = 195 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
506 9 0 5 6.7 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL259827 5ht7r_human Human No 6.7 IC50 = 200.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL405892 5ht7r_human Human No 6.7 IC50 = 200.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL261149 5ht7r_human Human No 6.7 IC50 = 200.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259827 5ht7r_human Human No 6.7 IC50 = 200.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL405892 5ht7r_human Human No 6.7 IC50 = 200.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL261149 5ht7r_human Human No 6.7 IC50 = 200.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL261232 5ht7r_human Human No 5.7 IC50 = 1999.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
512 9 1 6 3.7 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL261232 5ht7r_human Human No 5.7 IC50 = 1999.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
512 9 1 6 3.7 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL122536 5ht7r_human Human No 8.7 IC50 = 2.2 Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
205 3 1 2 2.1 CSC1=CC2=C(CC=C2CCN)C=C1
CHEMBL497749 5ht7r_human Human No 7.7 IC50 = 20 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
440 8 1 6 4.1 COC1=CC=CC=C1N2CCN(CC2)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL497749 5ht7r_human Human No 7.7 IC50 = 20 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
440 8 1 6 4.1 COC1=CC=CC=C1N2CCN(CC2)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL428781 5ht7r_human Human No 7.7 IC50 = 21.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
512 9 1 6 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL428781 5ht7r_human Human No 7.7 IC50 = 21.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
512 9 1 6 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL259827 5ht7r_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL405892 5ht7r_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL261149 5ht7r_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259827 5ht7r_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL405892 5ht7r_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL261149 5ht7r_human Human No 6.7 IC50 = 200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL261232 5ht7r_human Human No 5.7 IC50 = 2000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
512 9 1 6 3.7 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL261232 5ht7r_human Human No 5.7 IC50 = 2000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
512 9 1 6 3.7 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL1642123 5ht7r_human Human No 5.7 IC50 = 2007 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
450 3 0 6 3.7 CC1CC(=O)C2=C(C=CC=C2N1S(=O)(=O)C3=CC4=CC=CC=C4C=C3)N5CCN(CC5)C
CHEMBL1642123 5ht7r_human Human No 5.7 IC50 = 2007 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
450 3 0 6 3.7 CC1CC(=O)C2=C(C=CC=C2N1S(=O)(=O)C3=CC4=CC=CC=C4C=C3)N5CCN(CC5)C
CHEMBL113956 5ht7r_human Human No 5.7 IC50 = 2040 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
522 11 1 5 6.0 CCOC1=CC=C(C=C1)CCNC(=O)N2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL1221452 5ht7r_human Human No 5.7 IC50 = 2044 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
472 6 0 5 5.3 CN1CCN(CC1)C2=CC(=CC=C2)N(CC3=CC=CC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL1221452 5ht7r_human Human No 5.7 IC50 = 2044 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
472 6 0 5 5.3 CN1CCN(CC1)C2=CC(=CC=C2)N(CC3=CC=CC=C3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL1222364 5ht7r_human Human No 5.7 IC50 = 2059 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
410 5 0 5 4.2 CCN(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL1222364 5ht7r_human Human No 5.7 IC50 = 2059 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
410 5 0 5 4.2 CCN(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL260902 5ht7r_human Human No 6.7 IC50 = 209.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 10 1 7 3.6 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL260902 5ht7r_human Human No 6.7 IC50 = 209.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 10 1 7 3.6 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL428781 5ht7r_human Human No 7.7 IC50 = 21 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
512 9 1 6 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL428781 5ht7r_human Human No 7.7 IC50 = 21 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
512 9 1 6 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260902 5ht7r_human Human No 6.7 IC50 = 210 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 10 1 7 3.6 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL260902 5ht7r_human Human No 6.7 IC50 = 210 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 10 1 7 3.6 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL117537 5ht7r_human Human No 5.7 IC50 = 2130 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
477 10 0 4 6.1 C1CN(CCN1CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)CCCC4=CC=CC=C4
CHEMBL260003 5ht7r_human Human No 5.7 IC50 = 2197.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL260003 5ht7r_human Human No 5.7 IC50 = 2197.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL3321794 5ht7r_human Human No 5.7 IC50 = 2200 Funct
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
346 6 0 2 3.8 C1CN(CC2=CC=CC=C21)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL260003 5ht7r_human Human No 5.7 IC50 = 2200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL3321794 5ht7r_human Human No 5.7 IC50 = 2200 Funct
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
346 6 0 2 3.8 C1CN(CC2=CC=CC=C21)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL260003 5ht7r_human Human No 5.7 IC50 = 2200 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL493416 5ht7r_human Human No 6.7 IC50 = 223 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
440 8 1 6 4.1 COC1=CC=CC(=C1)N2CCN(CC2)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL493416 5ht7r_human Human No 6.7 IC50 = 223 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
440 8 1 6 4.1 COC1=CC=CC(=C1)N2CCN(CC2)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL604952 5ht7r_human Human No 5.6 IC50 = 2296 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
576 9 0 6 7.0 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC(=C(C=C3)Cl)Cl)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL604952 5ht7r_human Human No 5.6 IC50 = 2296 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
576 9 0 6 7.0 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC(=C(C=C3)Cl)Cl)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL260804 5ht7r_human Human No 6.6 IC50 = 230 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
560 10 1 8 3.7 COC1=CC=CC(=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL260804 5ht7r_human Human No 6.6 IC50 = 230 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
560 10 1 8 3.7 COC1=CC=CC(=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL260804 5ht7r_human Human No 6.6 IC50 = 230.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
560 10 1 8 3.7 COC1=CC=CC(=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL260804 5ht7r_human Human No 6.6 IC50 = 230.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
560 10 1 8 3.7 COC1=CC=CC(=C1)N2C(=NC3=C(C2=O)C=C(C=C3)F)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL3321798 5ht7r_human Human No 5.6 IC50 = 2300 Funct
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
353 6 0 2 4.6 C1CCC2CN(CCC2C1)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL3321798 5ht7r_human Human No 5.6 IC50 = 2300 Funct
Antagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assayAntagonist activity at human 5-HT7 expressed in HEK-293 cells assessed as inhibition in serotonin-induced increase in cAMP level after 45 mins by HTRF assay
353 6 0 2 4.6 C1CCC2CN(CCC2C1)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL261100 5ht7r_human Human No 5.6 IC50 = 2398.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL261100 5ht7r_human Human No 5.6 IC50 = 2398.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL3770581 5ht7r_human Human No 4.6 IC50 = 23996 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
495 6 2 6 3.4 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC(=C(C=C3)Cl)Cl)O)C4=CC=C(C=C4)F
CHEMBL3770581 5ht7r_human Human No 4.6 IC50 = 23996 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
495 6 2 6 3.4 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC(=C(C=C3)Cl)Cl)O)C4=CC=C(C=C4)F
CHEMBL601885 5ht7r_human Human No 7.6 IC50 = 24 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
537 10 0 7 5.7 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CCCCC3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL601885 5ht7r_human Human No 7.6 IC50 = 24 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
537 10 0 7 5.7 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CCCCC3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL261100 5ht7r_human Human No 5.6 IC50 = 2400 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL261100 5ht7r_human Human No 5.6 IC50 = 2400 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL409107 5ht7r_human Human No 5.6 IC50 = 2500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 7 3.4 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL409107 5ht7r_human Human No 5.6 IC50 = 2500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 7 3.4 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL409107 5ht7r_human Human No 5.6 IC50 = 2500.4 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 7 3.4 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL409107 5ht7r_human Human No 5.6 IC50 = 2500.4 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 7 3.4 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL399203 5ht7r_human Human No 4.6 IC50 = 25000 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
426 4 3 7 2.8 C1=CC=C(C=C1)OC2=CC=CC=C2NC3=NS(=O)(=O)C4=CC(=CC(=C4N3)O)[N+](=O)[O-]
CHEMBL399203 5ht7r_human Human No 4.6 IC50 = 25000 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
426 4 3 7 2.8 C1=CC=C(C=C1)OC2=CC=CC=C2NC3=NS(=O)(=O)C4=CC(=CC(=C4N3)O)[N+](=O)[O-]
CHEMBL261231 5ht7r_human Human No 7.6 IC50 = 26 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
526 10 1 6 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL261231 5ht7r_human Human No 7.6 IC50 = 26 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
526 10 1 6 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL261231 5ht7r_human Human No 7.6 IC50 = 26 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
526 10 1 6 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL261231 5ht7r_human Human No 7.6 IC50 = 26 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
526 10 1 6 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL411104 5ht7r_human Human No 6.6 IC50 = 260 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL411104 5ht7r_human Human No 6.6 IC50 = 260 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL411104 5ht7r_human Human No 6.6 IC50 = 260.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL411104 5ht7r_human Human No 6.6 IC50 = 260.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL407966 5ht7r_human Human No 6.6 IC50 = 269.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL407966 5ht7r_human Human No 6.6 IC50 = 269.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL407966 5ht7r_human Human No 6.6 IC50 = 270 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL407966 5ht7r_human Human No 6.6 IC50 = 270 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL260756 5ht7r_human Human No 7.5 IC50 = 29.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)OC
CHEMBL408717 5ht7r_human Human No 7.5 IC50 = 29.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL260756 5ht7r_human Human No 7.5 IC50 = 29.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)OC
CHEMBL408717 5ht7r_human Human No 7.5 IC50 = 29.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL2312934 5ht7r_human Human No 5.6 IC50 = 2800 Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
479 7 1 6 4.4 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=C(C=CC=N3)C=C2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL1222234 5ht7r_human Human No 5.5 IC50 = 2874 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
424 5 0 5 4.6 CC(C)N(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC=CC4=CC=CC=C43
CHEMBL1222234 5ht7r_human Human No 5.5 IC50 = 2874 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
424 5 0 5 4.6 CC(C)N(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC=CC4=CC=CC=C43
CHEMBL522006 5ht7r_human Human No 6.5 IC50 = 289 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
408 8 1 7 2.9 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=CC=C3F
CHEMBL522006 5ht7r_human Human No 6.5 IC50 = 289 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
408 8 1 7 2.9 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=CC=C3F
CHEMBL260756 5ht7r_human Human No 7.5 IC50 = 29 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)OC
CHEMBL408717 5ht7r_human Human No 7.5 IC50 = 29 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL260756 5ht7r_human Human No 7.5 IC50 = 29 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)OC
CHEMBL408717 5ht7r_human Human No 7.5 IC50 = 29 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC
CHEMBL439849 5ht7r_rat Rat Yes 5.5 IC50 = 3000 Funct
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL364005 5ht7r_human Human Yes 5.5 IC50 = 3000 Funct
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
247 1 2 1 2.8 CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3
CHEMBL439849 5ht7r_rat Rat Yes 5.5 IC50 = 3000 Funct
Inhibition of rat hydroxytryptamine 7 receptorInhibition of rat hydroxytryptamine 7 receptor
442 7 2 5 4.0 C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
CHEMBL364005 5ht7r_human Human Yes 5.5 IC50 = 3000 Funct
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
247 1 2 1 2.8 CC1=C(C2=C(N1)C=CC(=C2)Cl)C3=CCNCC3
CHEMBL1221449 5ht7r_human Human No 5.5 IC50 = 3038 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
436 6 0 5 4.6 CN1CCN(CC1)C2=CC(=CC=C2)N(CC3CC3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL1221449 5ht7r_human Human No 5.5 IC50 = 3038 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
436 6 0 5 4.6 CN1CCN(CC1)C2=CC(=CC=C2)N(CC3CC3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL2376483 5ht7r_human Human Yes 5.5 IC50 = 3100 Funct
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
230 1 2 2 2.3 CC1=C(C2=C(N1)C=CC(=C2)F)C3=CCNCC3
CHEMBL603499 5ht7r_human Human No 6.5 IC50 = 316 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
454 8 1 6 4.5 CC(CCN1CCN(CC1)C2=CC=CC=C2OC)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL601250 5ht7r_human Human No 6.5 IC50 = 316 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
474 11 0 7 3.7 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3OC)CC4CC4
CHEMBL603499 5ht7r_human Human No 6.5 IC50 = 316 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
454 8 1 6 4.5 CC(CCN1CCN(CC1)C2=CC=CC=C2OC)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL601250 5ht7r_human Human No 6.5 IC50 = 316 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
474 11 0 7 3.7 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3OC)CC4CC4
CHEMBL494427 5ht7r_human Human No 5.5 IC50 = 3241 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
440 8 1 6 4.1 COC1=CC=C(C=C1)N2CCN(CC2)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL494427 5ht7r_human Human No 5.5 IC50 = 3241 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
440 8 1 6 4.1 COC1=CC=C(C=C1)N2CCN(CC2)CCCNS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL1086754 5ht7r_human Human No 6.5 IC50 = 333 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
485 7 1 3 5.2 CC1=C(C=C(N1C)C2=CC=CC=C2)C(=O)NCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
CHEMBL1086754 5ht7r_human Human No 6.5 IC50 = 333 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
485 7 1 3 5.2 CC1=C(C=C(N1C)C2=CC=CC=C2)C(=O)NCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
CHEMBL601458 5ht7r_human Human No 6.5 IC50 = 334 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
482 9 0 8 4.7 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F
CHEMBL601458 5ht7r_human Human No 6.5 IC50 = 334 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
482 9 0 8 4.7 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F
CHEMBL493810 5ht7r_human Human No 6.5 IC50 = 339 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
420 9 1 7 2.8 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC(=CC=C3)OC
CHEMBL493810 5ht7r_human Human No 6.5 IC50 = 339 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
420 9 1 7 2.8 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC(=CC=C3)OC
CHEMBL601220 5ht7r_human Human No 6.5 IC50 = 342 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
532 9 0 8 5.9 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL601220 5ht7r_human Human No 6.5 IC50 = 342 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
532 9 0 8 5.9 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL3770639 5ht7r_human Human No 6.5 IC50 = 343 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
452 6 2 7 1.9 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC=CC=C3C#N)O)C4=CC=C(C=C4)F
CHEMBL3770639 5ht7r_human Human No 6.5 IC50 = 343 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
452 6 2 7 1.9 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC=CC=C3C#N)O)C4=CC=C(C=C4)F
CHEMBL3302600 5ht7r_human Human No 6.5 IC50 = 347 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
457 7 2 7 2.1 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)C4=CC=C(C=C4)F
CHEMBL3302600 5ht7r_human Human No 6.5 IC50 = 347 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
457 7 2 7 2.1 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC=CC=C3OC)O)C4=CC=C(C=C4)F
CHEMBL261573 5ht7r_human Human No 6.5 IC50 = 350.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
550 8 1 8 4.6 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL259236 5ht7r_human Human No 6.5 IC50 = 350.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL261573 5ht7r_human Human No 6.5 IC50 = 350.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
550 8 1 8 4.6 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL259236 5ht7r_human Human No 6.5 IC50 = 350.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL602889 5ht7r_human Human No 7.5 IC50 = 35.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
483 9 0 7 4.2 C1CC1CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL602889 5ht7r_human Human No 7.5 IC50 = 35.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
483 9 0 7 4.2 C1CC1CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL261573 5ht7r_human Human No 6.5 IC50 = 350 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
550 8 1 8 4.6 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL259236 5ht7r_human Human No 6.5 IC50 = 350 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL261573 5ht7r_human Human No 6.5 IC50 = 350 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
550 8 1 8 4.6 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL259236 5ht7r_human Human No 6.5 IC50 = 350 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL603093 5ht7r_human Human No 6.4 IC50 = 363 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
492 7 1 8 5.4 CC(CCN1CCN(CC1)C2=CC=CC(=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL603093 5ht7r_human Human No 6.4 IC50 = 363 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
492 7 1 8 5.4 CC(CCN1CCN(CC1)C2=CC=CC(=C2)C(F)(F)F)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL258525 5ht7r_human Human No 6.4 IC50 = 369.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL258525 5ht7r_human Human No 6.4 IC50 = 369.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL427518 5ht7r_human Human No 7.4 IC50 = 37 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
420 9 1 7 2.8 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL427518 5ht7r_human Human No 7.4 IC50 = 37 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
420 9 1 7 2.8 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=CC=C3OC
CHEMBL258525 5ht7r_human Human No 6.4 IC50 = 370 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL258525 5ht7r_human Human No 6.4 IC50 = 370 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL2376491 5ht7r_human Human No 5.4 IC50 = 3700 Funct
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
288 2 2 1 3.8 CC1=C(C2=C(N1)C=CC(=C2)C3=CC=CC=C3)C4=CCNCC4
CHEMBL495685 5ht7r_human Human No 6.4 IC50 = 373 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
422 8 1 7 3.4 CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL495685 5ht7r_human Human No 6.4 IC50 = 373 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
422 8 1 7 3.4 CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL495890 5ht7r_human Human No 6.4 IC50 = 377 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
404 8 1 6 3.3 CC(CCN1CCN(CC1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL495890 5ht7r_human Human No 6.4 IC50 = 377 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
404 8 1 6 3.3 CC(CCN1CCN(CC1)C2=CC=CC=C2)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL2312637 5ht7r_human Human No 5.4 IC50 = 3800 Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
493 8 1 6 4.8 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=C(C=CC=N3)C=C2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL523519 5ht7r_human Human No 6.4 IC50 = 384 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
458 8 1 9 3.7 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL523519 5ht7r_human Human No 6.4 IC50 = 384 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
458 8 1 9 3.7 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=C(C=C3)C(F)(F)F
CHEMBL1222363 5ht7r_human Human No 5.4 IC50 = 3865 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
424 6 0 5 4.7 CCCN(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL1222363 5ht7r_human Human No 5.4 IC50 = 3865 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
424 6 0 5 4.7 CCCN(C1=CC=CC(=C1)N2CCN(CC2)C)S(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL409358 5ht7r_human Human No 6.4 IC50 = 399.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL409358 5ht7r_human Human No 6.4 IC50 = 399.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL409358 5ht7r_human Human No 6.4 IC50 = 400 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL409358 5ht7r_human Human No 6.4 IC50 = 400 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL1086756 5ht7r_human Human No 6.4 IC50 = 408 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
514 9 1 3 6.1 CCCN1C(=C(C=C1C2=CC=CC=C2)C(=O)NCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl)C
CHEMBL1086756 5ht7r_human Human No 6.4 IC50 = 408 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
514 9 1 3 6.1 CCCN1C(=C(C=C1C2=CC=CC=C2)C(=O)NCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl)C
CHEMBL3343673 5ht7r_human Human No 7.4 IC50 = 41 Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.2 C1CC2(C3=CC=CC=C3C4=C2C=C(C=C4)C(=O)N=C(N)N)OC1
CHEMBL3343673 5ht7r_human Human No 7.4 IC50 = 41 Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA systemAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as cAMP production by EIA system
307 1 2 2 2.2 C1CC2(C3=CC=CC=C3C4=C2C=C(C=C4)C(=O)N=C(N)N)OC1
CHEMBL602285 5ht7r_human Human No 6.4 IC50 = 419 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
507 9 0 6 5.7 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL602285 5ht7r_human Human No 6.4 IC50 = 419 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
507 9 0 6 5.7 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL260648 5ht7r_human Human No 6.4 IC50 = 419.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL260029 5ht7r_human Human No 6.4 IC50 = 419.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260648 5ht7r_human Human No 6.4 IC50 = 419.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL260029 5ht7r_human Human No 6.4 IC50 = 419.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL259408 5ht7r_human Human No 7.4 IC50 = 42 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL259408 5ht7r_human Human No 7.4 IC50 = 42 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL260648 5ht7r_human Human No 6.4 IC50 = 420 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL260029 5ht7r_human Human No 6.4 IC50 = 420 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260648 5ht7r_human Human No 6.4 IC50 = 420 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL260029 5ht7r_human Human No 6.4 IC50 = 420 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=CC(=C(C=C1)C)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL2164336 5ht7r_human Human No 6.4 IC50 = 438 Funct
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
268 3 1 3 3.5 COC1=CC=C(C=C1)C2=CC=CC=C2N3CCNCC3
CHEMBL436700 5ht7r_human Human No 7.4 IC50 = 45.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
512 9 1 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL436700 5ht7r_human Human No 7.4 IC50 = 45.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
512 9 1 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL601887 5ht7r_human Human No 6.4 IC50 = 442 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
525 9 0 7 5.8 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL601887 5ht7r_human Human No 6.4 IC50 = 442 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
525 9 0 7 5.8 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL115229 5ht7r_human Human No 5.4 IC50 = 4420 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
394 3 1 6 2.2 C1CN(CC=C1N2C3=CC=CC=C3NC2=O)CC4=CC5=C(C=C4[N+](=O)[O-])OCO5
CHEMBL1222362 5ht7r_human Human No 5.4 IC50 = 4425 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
396 4 0 5 3.8 CN1CCN(CC1)C2=CC(=CC=C2)N(C)S(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL1222362 5ht7r_human Human No 5.4 IC50 = 4425 Funct
Displacement of [3H]LSD from human 5HT7 expressed in CHOKI cellsDisplacement of [3H]LSD from human 5HT7 expressed in CHOKI cells
396 4 0 5 3.8 CN1CCN(CC1)C2=CC(=CC=C2)N(C)S(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL260076 5ht7r_human Human No 6.4 IC50 = 449.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL409157 5ht7r_human Human No 6.4 IC50 = 449.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL260076 5ht7r_human Human No 6.4 IC50 = 449.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL409157 5ht7r_human Human No 6.4 IC50 = 449.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL436700 5ht7r_human Human No 7.4 IC50 = 45 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
512 9 1 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL436700 5ht7r_human Human No 7.4 IC50 = 45 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
512 9 1 6 3.7 CCOC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260076 5ht7r_human Human No 6.4 IC50 = 450 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL409157 5ht7r_human Human No 6.4 IC50 = 450 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL260076 5ht7r_human Human No 6.4 IC50 = 450 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 6 5.1 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC(=C(C=C5)Cl)Cl
CHEMBL409157 5ht7r_human Human No 6.4 IC50 = 450 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
516 8 1 5 4.3 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)Cl
CHEMBL602274 5ht7r_human Human No 6.3 IC50 = 456 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
524 9 0 8 6.3 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F
CHEMBL1086626 5ht7r_human Human No 6.3 IC50 = 456 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
471 7 2 3 5.3 CC1=C(C=C(N1)C2=CC=CC=C2)C(=O)NCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
CHEMBL602274 5ht7r_human Human No 6.3 IC50 = 456 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
524 9 0 8 6.3 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)C(F)(F)F
CHEMBL1086626 5ht7r_human Human No 6.3 IC50 = 456 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
471 7 2 3 5.3 CC1=C(C=C(N1)C2=CC=CC=C2)C(=O)NCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
CHEMBL259415 5ht7r_human Human No 6.3 IC50 = 460 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL259415 5ht7r_human Human No 6.3 IC50 = 460 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL259415 5ht7r_human Human No 6.3 IC50 = 460.3 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL259415 5ht7r_human Human No 6.3 IC50 = 460.3 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL261572 5ht7r_human Human No 6.3 IC50 = 469.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL261572 5ht7r_human Human No 6.3 IC50 = 469.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL493816 5ht7r_human Human No 7.3 IC50 = 47 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
408 8 1 7 2.9 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=C(C=C3)F
CHEMBL493816 5ht7r_human Human No 7.3 IC50 = 47 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
408 8 1 7 2.9 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=C(C=C3)F
CHEMBL259001 5ht7r_human Human No 7.3 IC50 = 48.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL259001 5ht7r_human Human No 7.3 IC50 = 48.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL261572 5ht7r_human Human No 6.3 IC50 = 470 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL261572 5ht7r_human Human No 6.3 IC50 = 470 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL494573 5ht7r_human Human No 6.3 IC50 = 476 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
424 8 1 5 3.8 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)CC4=CC=CC=C4
CHEMBL494573 5ht7r_human Human No 6.3 IC50 = 476 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
424 8 1 5 3.8 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)CC4=CC=CC=C4
CHEMBL481245 5ht7r_human Human Yes 4.3 IC50 = 47600 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
314 7 2 5 3.4 COC1=C(C=CC(=C1)C=CC(=O)OCCC2=CC=C(C=C2)O)O
CHEMBL481245 5ht7r_human Human Yes 4.3 IC50 = 47600 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells by liquid scintillation counting
314 7 2 5 3.4 COC1=C(C=CC(=C1)C=CC(=O)OCCC2=CC=C(C=C2)O)O
CHEMBL571858 5ht7r_human Human Yes 5.3 IC50 = 4764 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
347 5 0 5 2.1 CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F
CHEMBL571858 5ht7r_human Human Yes 5.3 IC50 = 4764 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
347 5 0 5 2.1 CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F
CHEMBL259001 5ht7r_human Human No 7.3 IC50 = 48 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL259001 5ht7r_human Human No 7.3 IC50 = 48 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL259199 5ht7r_human Human No 7.3 IC50 = 49.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL259199 5ht7r_human Human No 7.3 IC50 = 49.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL2376482 5ht7r_human Human Yes 6.3 IC50 = 480 Funct
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
291 1 2 1 2.9 CC1=C(C2=C(N1)C=CC(=C2)Br)C3=CCNCC3
CHEMBL259199 5ht7r_human Human No 7.3 IC50 = 49 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL259199 5ht7r_human Human No 7.3 IC50 = 49 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=C(C=C5)OC
CHEMBL600606 5ht7r_human Human No 7.3 IC50 = 49.6 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
482 9 0 6 5.2 C1CC1CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL600606 5ht7r_human Human No 7.3 IC50 = 49.6 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
482 9 0 6 5.2 C1CC1CN(CCCN2CCN(CC2)C3=CC=C(C=C3)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL1088313 5ht7r_human Human No 6.3 IC50 = 493 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
555 8 1 4 6.6 CC1=C(C=C(N1N2CCCCC2)C3=CC=CC=C3)C(=O)NCCCN4CCN(CC4)C5=C(C(=CC=C5)Cl)Cl
CHEMBL1088313 5ht7r_human Human No 6.3 IC50 = 493 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
555 8 1 4 6.6 CC1=C(C=C(N1N2CCCCC2)C3=CC=CC=C3)C(=O)NCCCN4CCN(CC4)C5=C(C(=CC=C5)Cl)Cl
CHEMBL261151 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
514 7 1 6 4.2 CC1=C(C(=CC=C1)C)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL261653 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
514 7 1 6 4.2 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F)C
CHEMBL601037 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
459 9 0 7 3.6 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL600210 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
536 10 0 6 6.6 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CCCCC3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL261151 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
514 7 1 6 4.2 CC1=C(C(=CC=C1)C)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL261653 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
514 7 1 6 4.2 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F)C
CHEMBL601037 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
459 9 0 7 3.6 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL600210 5ht7r_human Human No 6.3 IC50 = 500 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
536 10 0 6 6.6 COC1=CC=CC=C1N2CCN(CC2)CCCN(CC3CCCCC3)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL261151 5ht7r_human Human No 6.3 IC50 = 500.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
514 7 1 6 4.2 CC1=C(C(=CC=C1)C)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL261653 5ht7r_human Human No 6.3 IC50 = 500.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
514 7 1 6 4.2 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F)C
CHEMBL261151 5ht7r_human Human No 6.3 IC50 = 500.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
514 7 1 6 4.2 CC1=C(C(=CC=C1)C)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F
CHEMBL261653 5ht7r_human Human No 6.3 IC50 = 500.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
514 7 1 6 4.2 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=C(C=C5)F)C
CHEMBL410042 5ht7r_human Human No 6.3 IC50 = 510 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL410042 5ht7r_human Human No 6.3 IC50 = 510 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL410042 5ht7r_human Human No 6.3 IC50 = 510.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL410042 5ht7r_human Human No 6.3 IC50 = 510.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
502 7 1 5 4.0 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL565552 5ht7r_human Human No 6.3 IC50 = 511 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
379 5 0 4 3.3 CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC4=CC=CC=C43
CHEMBL565552 5ht7r_human Human No 6.3 IC50 = 511 Funct
Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells
379 5 0 4 3.3 CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC4=CC=CC=C43
CHEMBL259408 5ht7r_human Human No 7.3 IC50 = 52 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL259408 5ht7r_human Human No 7.3 IC50 = 52 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
534 8 1 6 4.4 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5Cl
CHEMBL1088314 5ht7r_human Human No 6.3 IC50 = 524 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
566 8 1 4 7.0 CC1=C(C=C(N1C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NCCCN4CCN(CC4)C5=C(C(=CC=C5)Cl)Cl
CHEMBL1088314 5ht7r_human Human No 6.3 IC50 = 524 Funct
Inhibition of 5HT7 receptorInhibition of 5HT7 receptor
566 8 1 4 7.0 CC1=C(C=C(N1C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NCCCN4CCN(CC4)C5=C(C(=CC=C5)Cl)Cl
CHEMBL602279 5ht7r_human Human No 6.3 IC50 = 526 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
442 7 1 6 4.7 CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL602279 5ht7r_human Human No 6.3 IC50 = 526 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
442 7 1 6 4.7 CC(CCN1CCN(CC1)C2=CC=C(C=C2)F)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL495445 5ht7r_human Human No 7.3 IC50 = 53 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
428 7 1 6 4.2 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=C(C=C4)F
CHEMBL495445 5ht7r_human Human No 7.3 IC50 = 53 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
428 7 1 6 4.2 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=C(C=C4)F
CHEMBL494675 5ht7r_human Human Yes 6.3 IC50 = 531 Funct
Antagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISAAntagonist activity at human 5HT7A receptor expressed in human HeLa cells assessed as inhibition of 5-HT-induced cAMP accumulation by ELISA
238 2 1 2 3.5 C1CN(CCN1)C2=CC=CC=C2C3=CC=CC=C3
CHEMBL260022 5ht7r_human Human No 7.3 IC50 = 55.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC(=CC=C5)OC
CHEMBL261434 5ht7r_human Human No 7.3 IC50 = 55.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL260022 5ht7r_human Human No 7.3 IC50 = 55.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC(=CC=C5)OC
CHEMBL261434 5ht7r_human Human No 7.3 IC50 = 55.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL3262428 5ht7r_human Human No 6.3 IC50 = 540 Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation
339 7 1 4 4.0 CN(CCCCN1CCN(CC1)C2=CC=CC=C2)C3=CC(=CC=C3)O
CHEMBL3262428 5ht7r_human Human No 6.3 IC50 = 540 Funct
Antagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulationAntagonist activity at human 5-HT7 receptor expressed in CHO cells assessed as inhibition of 5-HT-stimulated cAMP accumulation
339 7 1 4 4.0 CN(CCCCN1CCN(CC1)C2=CC=CC=C2)C3=CC(=CC=C3)O
CHEMBL313714 5ht7r_rat Rat Yes 6.3 IC50 = 540 Funct
Compound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cellsCompound was tested for the displacement of [3H]5-HT binding to cloned rat 5-hydroxytryptamine 7 receptor stably expressed in CHO cells
463 9 3 6 2.9 C1CN(CCC1NC(CO)C2=CC=C(C=C2)F)CCCC3=CNC4=C3C=C(C=C4)N5C=NN=C5
CHEMBL260022 5ht7r_human Human No 7.3 IC50 = 55 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC(=CC=C5)OC
CHEMBL261434 5ht7r_human Human No 7.3 IC50 = 55 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL260022 5ht7r_human Human No 7.3 IC50 = 55 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
556 11 1 7 4.0 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC(=CC=C5)OC
CHEMBL261434 5ht7r_human Human No 7.3 IC50 = 55 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL2312639 5ht7r_human Human No 5.3 IC50 = 5600 Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
493 8 1 6 5.0 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=CC=CC=C3C=N2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL495884 5ht7r_human Human No 6.3 IC50 = 567 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
478 7 1 8 5.0 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=C(C=C4)C(F)(F)F
CHEMBL601872 5ht7r_human Human No 6.3 IC50 = 567 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
486 10 0 6 5.4 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3)CC4CCCCC4
CHEMBL495884 5ht7r_human Human No 6.3 IC50 = 567 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
478 7 1 8 5.0 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=C(C=C4)C(F)(F)F
CHEMBL601872 5ht7r_human Human No 6.3 IC50 = 567 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
486 10 0 6 5.4 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC=C3)CC4CCCCC4
CHEMBL493402 5ht7r_human Human No 6.2 IC50 = 580 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
434 9 1 7 3.3 CC(CCN1CCN(CC1)C2=CC=CC=C2OC)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL493402 5ht7r_human Human No 6.2 IC50 = 580 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
434 9 1 7 3.3 CC(CCN1CCN(CC1)C2=CC=CC=C2OC)NS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL260903 5ht7r_human Human No 6.2 IC50 = 590 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261337 5ht7r_human Human No 6.2 IC50 = 590 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260903 5ht7r_human Human No 6.2 IC50 = 590 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261337 5ht7r_human Human No 6.2 IC50 = 590 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260903 5ht7r_human Human No 6.2 IC50 = 590.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261337 5ht7r_human Human No 6.2 IC50 = 590.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260903 5ht7r_human Human No 6.2 IC50 = 590.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261337 5ht7r_human Human No 6.2 IC50 = 590.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL3769441 5ht7r_human Human No 5.2 IC50 = 5943 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
457 7 2 7 2.1 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC(=CC=C3)OC)O)C4=CC=C(C=C4)F
CHEMBL3769441 5ht7r_human Human No 5.2 IC50 = 5943 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
457 7 2 7 2.1 CC1(C(=O)N(C(=O)N1)CC(CN2CCN(CC2)C3=CC(=CC=C3)OC)O)C4=CC=C(C=C4)F
CHEMBL602878 5ht7r_human Human No 8.2 IC50 = 6.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
533 9 0 9 5.0 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL602878 5ht7r_human Human No 8.2 IC50 = 6.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
533 9 0 9 5.0 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL261433 5ht7r_human Human No 6.2 IC50 = 619.4 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261433 5ht7r_human Human No 6.2 IC50 = 619.4 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL2392349 5ht7r_human Human No 7.2 IC50 = 62 Funct
Inhibition of human 5-HT7 receptorInhibition of human 5-HT7 receptor
444 8 0 4 4.9 COC1=CC=CC=C1N2CCN(CC2)CCCCCN3CC4=C(C3=O)C5=CC=CC=C5C=C4
CHEMBL1642117 5ht7r_human Human No 6.2 IC50 = 620 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
436 3 0 6 3.3 CN1CCN(CC1)C2=C3C(=O)CCN(C3=CC=C2)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL261433 5ht7r_human Human No 6.2 IC50 = 620 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL1642117 5ht7r_human Human No 6.2 IC50 = 620 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in cells
436 3 0 6 3.3 CN1CCN(CC1)C2=C3C(=O)CCN(C3=CC=C2)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL261433 5ht7r_human Human No 6.2 IC50 = 620 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL487805 5ht7r_human Human Yes 4.2 IC50 = 63400 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
462 4 7 12 0.8 C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O)O
CHEMBL487805 5ht7r_human Human Yes 4.2 IC50 = 63400 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
462 4 7 12 0.8 C1=CC(=CC=C1C2=CC(=O)C3=C(C(=C(C=C3O2)OC4C(C(C(C(O4)C(=O)O)O)O)O)O)O)O
CHEMBL412153 5ht7r_human Human No 6.2 IC50 = 639.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
496 7 1 5 4.1 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL412153 5ht7r_human Human No 6.2 IC50 = 639.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
496 7 1 5 4.1 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL412153 5ht7r_human Human No 6.2 IC50 = 640 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
496 7 1 5 4.1 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL412153 5ht7r_human Human No 6.2 IC50 = 640 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
496 7 1 5 4.1 CC1=CC(=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL260249 5ht7r_human Human No 6.2 IC50 = 650 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
482 8 1 5 3.7 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL260249 5ht7r_human Human No 6.2 IC50 = 650 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
482 8 1 5 3.7 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL260249 5ht7r_human Human No 6.2 IC50 = 650.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
482 8 1 5 3.7 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL260249 5ht7r_human Human No 6.2 IC50 = 650.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
482 8 1 5 3.7 C1CN(CCN1CCCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL603092 5ht7r_human Human No 6.2 IC50 = 657 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
424 7 1 5 4.6 CC(CCN1CCN(CC1)C2=CC=CC=C2)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL603092 5ht7r_human Human No 6.2 IC50 = 657 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
424 7 1 5 4.6 CC(CCN1CCN(CC1)C2=CC=CC=C2)NS(=O)(=O)C3=CC4=CC=CC=C4C=C3
CHEMBL420863 5ht7r_human Human No 6.2 IC50 = 663 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
400 3 1 4 3.6 CC1=CC2=C(C=C1)NC(=O)N2C3CCN(CC3)CC4=CC5=C(C=C4Cl)OCO5
CHEMBL601022 5ht7r_human Human No 6.2 IC50 = 678 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
554 10 0 9 6.3 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)CC4CCCCC4
CHEMBL601022 5ht7r_human Human No 6.2 IC50 = 678 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
554 10 0 9 6.3 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)CC4CCCCC4
CHEMBL261018 5ht7r_human Human No 6.2 IC50 = 680 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259619 5ht7r_human Human No 6.2 IC50 = 680 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
486 7 1 6 3.4 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=CC=C5
CHEMBL261018 5ht7r_human Human No 6.2 IC50 = 680 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259619 5ht7r_human Human No 6.2 IC50 = 680 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
486 7 1 6 3.4 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=CC=C5
CHEMBL261018 5ht7r_human Human No 6.2 IC50 = 680.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259619 5ht7r_human Human No 6.2 IC50 = 680.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
486 7 1 6 3.4 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=CC=C5
CHEMBL261018 5ht7r_human Human No 6.2 IC50 = 680.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 9 1 7 3.5 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL259619 5ht7r_human Human No 6.2 IC50 = 680.8 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
486 7 1 6 3.4 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=CC=C5
CHEMBL522694 5ht7r_human Human Yes 6.2 IC50 = 681 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
410 7 1 5 4.1 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=CC=C4
CHEMBL522694 5ht7r_human Human Yes 6.2 IC50 = 681 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
410 7 1 5 4.1 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=CC=CC=C4
CHEMBL259414 5ht7r_human Human No 6.2 IC50 = 690 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL2376490 5ht7r_human Human No 6.2 IC50 = 690 Funct
Displacement of [3H]LSD from human 5HT7 receptorDisplacement of [3H]LSD from human 5HT7 receptor
294 2 2 2 3.5 CC1=C(C2=C(N1)C=CC(=C2)C3=CSC=C3)C4=CCNCC4
CHEMBL259414 5ht7r_human Human No 6.2 IC50 = 690 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 5 4.4 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL259414 5ht7r_human Human No 6.2 IC50 = 690.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL259414 5ht7r_human Human No 6.2 IC50 = 690.2 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 5 4.4 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL260023 5ht7r_human Human No 6.2 IC50 = 709.6 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
498 8 1 6 3.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260023 5ht7r_human Human No 6.2 IC50 = 709.6 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
498 8 1 6 3.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260023 5ht7r_human Human No 6.2 IC50 = 710 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
498 8 1 6 3.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260023 5ht7r_human Human No 6.2 IC50 = 710 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
498 8 1 6 3.3 COC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL325516 5ht7r_human Human No 6.1 IC50 = 726 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
497 10 0 6 6.3 C1CN(CCN1CCCC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F)C(=O)OCCC4=CC=C(C=C4)F
CHEMBL260250 5ht7r_human Human No 6.1 IC50 = 729.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
482 7 1 5 3.7 CC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260250 5ht7r_human Human No 6.1 IC50 = 729.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
482 7 1 5 3.7 CC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL262589 5ht7r_human Human No 5.1 IC50 = 7294.6 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
531 7 1 8 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL262589 5ht7r_human Human No 5.1 IC50 = 7294.6 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
531 7 1 8 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL260906 5ht7r_human Human No 7.1 IC50 = 74.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL260906 5ht7r_human Human No 7.1 IC50 = 74.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL260250 5ht7r_human Human No 6.1 IC50 = 730 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
482 7 1 5 3.7 CC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL260250 5ht7r_human Human No 6.1 IC50 = 730 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
482 7 1 5 3.7 CC1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL262589 5ht7r_human Human No 5.1 IC50 = 7300 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
531 7 1 8 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL262589 5ht7r_human Human No 5.1 IC50 = 7300 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
531 7 1 8 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)F)C5=CC=C(C=C5)[N+](=O)[O-]
CHEMBL260906 5ht7r_human Human No 7.1 IC50 = 74 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL260906 5ht7r_human Human No 7.1 IC50 = 74 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=C(C=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL261102 5ht7r_human Human No 7.1 IC50 = 75.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261102 5ht7r_human Human No 7.1 IC50 = 75.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL600607 5ht7r_human Human No 6.1 IC50 = 749 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
465 9 0 6 4.1 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL600607 5ht7r_human Human No 6.1 IC50 = 749 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
465 9 0 6 4.1 C1CC1CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC5=C4N=CC=C5
CHEMBL261102 5ht7r_human Human No 7.1 IC50 = 75 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261102 5ht7r_human Human No 7.1 IC50 = 75 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=C(C(=CC=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL114379 5ht7r_human Human No 6.1 IC50 = 762 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
386 3 1 4 3.3 C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC5=C(C=C4Cl)OCO5
CHEMBL260971 5ht7r_human Human No 6.1 IC50 = 769.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL261187 5ht7r_human Human No 6.1 IC50 = 769.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL260971 5ht7r_human Human No 6.1 IC50 = 769.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL261187 5ht7r_human Human No 6.1 IC50 = 769.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL260971 5ht7r_human Human No 6.1 IC50 = 770 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL261187 5ht7r_human Human No 6.1 IC50 = 770 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL260971 5ht7r_human Human No 6.1 IC50 = 770 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=C(C=C5)F
CHEMBL261187 5ht7r_human Human No 6.1 IC50 = 770 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
518 8 1 7 3.9 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5F
CHEMBL2312935 5ht7r_human Human No 5.1 IC50 = 7800 Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
493 8 1 6 4.8 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=CC=CC=C3N=C2)C4=C(C(=CC=C4)Cl)Cl
CHEMBL409156 5ht7r_human Human No 7.1 IC50 = 79 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
560 10 1 8 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL409156 5ht7r_human Human No 7.1 IC50 = 79 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
560 10 1 8 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL409156 5ht7r_human Human No 7.1 IC50 = 79.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
560 10 1 8 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL409156 5ht7r_human Human No 7.1 IC50 = 79.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
560 10 1 8 3.7 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5OC
CHEMBL259626 5ht7r_human Human No 7.1 IC50 = 80.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
498 8 1 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL259626 5ht7r_human Human No 7.1 IC50 = 80.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
498 8 1 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL259626 5ht7r_human Human No 7.1 IC50 = 80 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
498 8 1 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL259626 5ht7r_human Human No 7.1 IC50 = 80 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
498 8 1 6 3.3 COC1=CC=CC=C1N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL3769534 5ht7r_human Human No 7.1 IC50 = 81 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
471 8 2 7 2.5 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)C(NC3=O)(C)C4=CC=C(C=C4)F)O
CHEMBL3769534 5ht7r_human Human No 7.1 IC50 = 81 Funct
Antagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assayAntagonist activity at human 5-HT7 receptor expressed in HEK293 cells assessed as inhibition of 5-CT-induced cAMP production preincubated for 15 mins followed by 5-CT addition measured after 15 mins by HTRF assay
471 8 2 7 2.5 CCOC1=CC=CC=C1N2CCN(CC2)CC(CN3C(=O)C(NC3=O)(C)C4=CC=C(C=C4)F)O
CHEMBL2312640 5ht7r_human Human No 6.1 IC50 = 820 Funct
Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationAntagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulation
493 8 1 6 4.7 C1CN(CCN1CCCCNS(=O)(=O)C2=CN=CC3=CC=CC=C32)C4=C(C(=CC=C4)Cl)Cl
CHEMBL260705 5ht7r_human Human No 7.1 IC50 = 84.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260705 5ht7r_human Human No 7.1 IC50 = 84.9 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL114484 5ht7r_human Human No 6.1 IC50 = 849 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
356 3 1 2 4.5 CC1=CC(=C(C=C1)CN2CCC(CC2)N3C4=CC=CC=C4NC3=O)Cl
CHEMBL260705 5ht7r_human Human No 7.1 IC50 = 85 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL260705 5ht7r_human Human No 7.1 IC50 = 85 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL605582 5ht7r_human Human No 7.1 IC50 = 87 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
501 9 0 7 5.3 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL605582 5ht7r_human Human No 7.1 IC50 = 87 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
501 9 0 7 5.3 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC=C3)S(=O)(=O)C4=CC=C(C=C4)[N+](=O)[O-]
CHEMBL602087 5ht7r_human Human No 6.1 IC50 = 888 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
574 9 0 8 7.6 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL602087 5ht7r_human Human No 6.1 IC50 = 888 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
574 9 0 8 7.6 C1CCC(CC1)CN(CCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F)S(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL493625 5ht7r_human Human No 7.1 IC50 = 89 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
458 8 1 9 3.7 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F
CHEMBL493625 5ht7r_human Human No 7.1 IC50 = 89 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
458 8 1 9 3.7 COC1=CC=C(C=C1)S(=O)(=O)NCCCN2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F
CHEMBL410922 5ht7r_human Human No 5.1 IC50 = 8995.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 6 3.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL410922 5ht7r_human Human No 5.1 IC50 = 8995.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
510 8 1 6 3.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL258995 5ht7r_human Human No 7.0 IC50 = 91.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL258995 5ht7r_human Human No 7.0 IC50 = 91.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL410922 5ht7r_human Human No 5.1 IC50 = 9000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 6 3.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL410922 5ht7r_human Human No 5.1 IC50 = 9000 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
510 8 1 6 3.0 CC(=O)C1=CC=C(C=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5
CHEMBL258995 5ht7r_human Human No 7.0 IC50 = 91 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL258995 5ht7r_human Human No 7.0 IC50 = 91 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
574 11 1 8 4.1 CCOC1=CC=CC=C1N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC(=CC=C5)OC
CHEMBL261019 5ht7r_human Human No 7.0 IC50 = 92 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL261019 5ht7r_human Human No 7.0 IC50 = 92 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL261019 5ht7r_human Human No 7.0 IC50 = 92.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL261019 5ht7r_human Human No 7.0 IC50 = 92.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
568 8 1 9 4.7 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC(=C5)C(F)(F)F
CHEMBL410043 5ht7r_human Human No 6.0 IC50 = 920 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=CC(=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL410043 5ht7r_human Human No 6.0 IC50 = 920 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
530 9 1 7 3.8 COC1=CC=CC(=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL410043 5ht7r_human Human No 6.0 IC50 = 920.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=CC(=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL410043 5ht7r_human Human No 6.0 IC50 = 920.5 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
530 9 1 7 3.8 COC1=CC=CC(=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=C(C=C4)F)C(=O)N3C5=CC=CC=C5
CHEMBL410075 5ht7r_human Human No 6.0 IC50 = 929.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL410075 5ht7r_human Human No 6.0 IC50 = 929.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL601859 5ht7r_human Human No 7.0 IC50 = 93 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
462 10 0 7 3.9 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=C(C=C3)F)CC4CC4
CHEMBL601859 5ht7r_human Human No 7.0 IC50 = 93 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
462 10 0 7 3.9 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=C(C=C3)F)CC4CC4
CHEMBL410075 5ht7r_human Human No 6.0 IC50 = 930 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL410075 5ht7r_human Human No 6.0 IC50 = 930 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
500 8 1 6 3.8 C1CN(CCN1CCCC(=O)NCC2=NC3=C(C=CC(=C3)F)C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL493811 5ht7r_human Human No 5.0 IC50 = 9314 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
420 9 1 7 2.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCNS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL493811 5ht7r_human Human No 5.0 IC50 = 9314 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
420 9 1 7 2.8 COC1=CC=C(C=C1)N2CCN(CC2)CCCNS(=O)(=O)C3=CC=C(C=C3)OC
CHEMBL261099 5ht7r_human Human No 6.0 IC50 = 939.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261654 5ht7r_human Human No 6.0 IC50 = 939.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
468 7 1 5 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL261099 5ht7r_human Human No 6.0 IC50 = 939.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261654 5ht7r_human Human No 6.0 IC50 = 939.7 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
468 7 1 5 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL261099 5ht7r_human Human No 6.0 IC50 = 940 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261654 5ht7r_human Human No 6.0 IC50 = 940 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
468 7 1 5 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL261099 5ht7r_human Human No 6.0 IC50 = 940 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
528 8 1 6 4.5 CC1=CC(=C(C=C1)N2CCN(CC2)CCCC(=O)NCC3=NC4=C(C=CC(=C4)F)C(=O)N3C5=CC=CC=C5)C
CHEMBL261654 5ht7r_human Human No 6.0 IC50 = 940 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
468 7 1 5 3.3 C1CN(CCN1CCC(=O)NCC2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4)C5=CC=CC=C5
CHEMBL492794 5ht7r_human Human No 6.0 IC50 = 949 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
374 8 1 5 2.6 C1CN(CCN1CCCNS(=O)(=O)C2=CC=CC=C2)CC3=CC=CC=C3
CHEMBL492794 5ht7r_human Human No 6.0 IC50 = 949 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membraneDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cell membrane
374 8 1 5 2.6 C1CN(CCN1CCCNS(=O)(=O)C2=CC=CC=C2)CC3=CC=CC=C3
CHEMBL261291 5ht7r_human Human No 7.0 IC50 = 95 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
496 7 1 5 4.1 CC1=C(C(=CC=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL261291 5ht7r_human Human No 7.0 IC50 = 95 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
496 7 1 5 4.1 CC1=C(C(=CC=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL261291 5ht7r_human Human No 7.0 IC50 = 95.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
496 7 1 5 4.1 CC1=C(C(=CC=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL261291 5ht7r_human Human No 7.0 IC50 = 95.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
496 7 1 5 4.1 CC1=C(C(=CC=C1)N2CCN(CC2)CCC(=O)NCC3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5)C
CHEMBL258956 5ht7r_human Human No 7.0 IC50 = 97 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 10 1 7 3.6 COC1=CC=C(C=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL258956 5ht7r_human Human No 7.0 IC50 = 97 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 10 1 7 3.6 COC1=CC=C(C=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL258956 5ht7r_human Human No 7.0 IC50 = 97.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 10 1 7 3.6 COC1=CC=C(C=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL258956 5ht7r_human Human No 7.0 IC50 = 97.1 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 10 1 7 3.6 COC1=CC=C(C=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL407411 5ht7r_human Human No 7.0 IC50 = 98.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 10 1 7 3.6 COC1=CC=CC(=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL407411 5ht7r_human Human No 7.0 IC50 = 98.0 Funct
Inhibition of 5HT7 receptor by radioligand binding assayInhibition of 5HT7 receptor by radioligand binding assay
542 10 1 7 3.6 COC1=CC=CC(=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL407411 5ht7r_human Human No 7.0 IC50 = 98 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 10 1 7 3.6 COC1=CC=CC(=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL407411 5ht7r_human Human No 7.0 IC50 = 98 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptorDisplacement of [3H]LSD from human recombinant 5HT7 receptor
542 10 1 7 3.6 COC1=CC=CC(=C1)N2C(=NC3=CC=CC=C3C2=O)CNC(=O)CCCN4CCN(CC4)C5=CC=CC=C5OC
CHEMBL605787 5ht7r_human Human No 6.0 IC50 = 980 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
504 10 0 7 5.5 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=C(C=C3)F)CC4CCCCC4
CHEMBL605787 5ht7r_human Human No 6.0 IC50 = 980 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
504 10 0 7 5.5 COC1=CC=C(C=C1)S(=O)(=O)N(CCCN2CCN(CC2)C3=CC=C(C=C3)F)CC4CCCCC4
CHEMBL194305 5ht7r_human Human Yes 5.0 IC50 = 9800 Funct
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
242 2 2 2 2.2 CC1=C(C2=C(N1)C=CC(=C2)OC)C3=CCNCC3
CHEMBL194305 5ht7r_human Human Yes 5.0 IC50 = 9800 Funct
Inhibitory activity against 5-hydroxytryptamine 7 receptor in humanInhibitory activity against 5-hydroxytryptamine 7 receptor in human
242 2 2 2 2.2 CC1=C(C2=C(N1)C=CC(=C2)OC)C3=CCNCC3
CHEMBL116463 5ht7r_human Human No 6.0 IC50 = 998 Funct
Inhibition of human 5-hydroxytryptamine 7 receptorInhibition of human 5-hydroxytryptamine 7 receptor
518 11 1 6 6.5 C1CN(CCC1NC(=O)OCCC2=CC=C(C=C2)C#N)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
CHEMBL2442996 5ht7r_human Human No 8.9 Kd = 1.2 Funct
Displacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysisDisplacement of [3H]5-CT from human 5HT7 receptor transfected in HEK293 cells after 60 mins by Scatchard plot analysis
473 11 1 5 4.2 COC1=CC=C(C=C1)C2=CC=CC=C2N3CCN(CC3)CCCCCC(=O)NCC4=CC=NC=C4
CHEMBL222755 5ht7r_human Human No 7.8 Kd = 15.9 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
420 8 1 3 4.8 CC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL222755 5ht7r_human Human No 7.8 Kd = 15.9 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
420 8 1 3 4.8 CC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 7.7 Kd = 20.0 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL244161 5ht7r_cavpo Guinea pig No 7.7 Kd = 20.0 Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction
435 9 2 4 4.4 CNC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 7.7 Kd = 20.0 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL244161 5ht7r_cavpo Guinea pig No 7.7 Kd = 20.0 Funct
Antagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contractionAntagonist activity at 5HT7 receptor in guinea pig ileum assessed as effect on substance P-induced contraction
435 9 2 4 4.4 CNC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL389718 5ht7r_human Human No 7.6 Kd = 25.1 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
448 9 1 4 4.1 CC(=O)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL389718 5ht7r_human Human No 7.6 Kd = 25.1 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
448 9 1 4 4.1 CC(=O)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225512 5ht7r_human Human No 7.2 Kd = 63.1 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
422 8 2 4 4.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4O
CHEMBL225512 5ht7r_human Human No 7.2 Kd = 63.1 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
422 8 2 4 4.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4O
CHEMBL224820 5ht7r_human Human No 8.0 Kd = 9.6 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
436 9 1 4 4.4 COC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL224820 5ht7r_human Human No 8.0 Kd = 9.6 Funct
Activity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileumActivity at SB-269970 desensitized 5HT7 receptor assessed as reduction of substance P-induced contraction of Dunkin-Hartley guinea pig ileum
436 9 1 4 4.4 COC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL3289972 5ht7r_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
467 8 1 8 4.1 C1CN(CCN1CCCCNS(=O)(=O)C2=CC(=C(C=C2)F)Cl)C3=NOC4=CC=CC=C43
CHEMBL3289972 5ht7r_human Human No 10.0 Ki = 0.1 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
467 8 1 8 4.1 C1CN(CCN1CCCCNS(=O)(=O)C2=CC(=C(C=C2)F)Cl)C3=NOC4=CC=CC=C43
CHEMBL243954 5ht7r_rat Rat Yes 9.9 Ki = 0.1 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
482 9 1 3 6.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL243954 5ht7r_rat Rat Yes 9.9 Ki = 0.1 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
482 9 1 3 6.1 C1CC(C2=CC=CC=C2C1)NC(=O)CCCCCN3CCN(CC3)C4=CC=CC=C4C5=CC=CC=C5
CHEMBL592752 5ht7r_human Human Yes 9.8 Ki = 0.2 Funct
Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)Displacement of [3H]lysergic acid from 5-HT7 receptor (unknown origin)
304 3 0 1 4.2 CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
CHEMBL363452 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
351 8 2 5 4.8 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCOC3=CC=C(C=C3)F
CHEMBL363452 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
351 8 2 5 4.8 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCOC3=CC=C(C=C3)F
CHEMBL3290016 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
520 8 1 9 5.6 CC1=C(SC2=C1C=C(C=C2)F)S(=O)(=O)NCCCCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL363452 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
351 8 2 5 4.8 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCOC3=CC=C(C=C3)F
CHEMBL363452 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
351 8 2 5 4.8 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCOC3=CC=C(C=C3)F
CHEMBL3290016 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
520 8 1 9 5.6 CC1=C(SC2=C1C=C(C=C2)F)S(=O)(=O)NCCCCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL605405 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
302 2 0 1 4.4 CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)C=CC4=CC=CC=C4
CHEMBL605405 5ht7r_human Human No 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
302 2 0 1 4.4 CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)C=CC4=CC=CC=C4
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assayDisplacement of [3H]LSD from rat recombinant 5-HT7 receptor expressed in HEK293 cell membranes incubated for 60 mins by radioligand binding assay
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 cells after 1 hr
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_human Human Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 minsDisplacement of [3H]LSD from rat cloned 5-Hydroxytryptamine receptor 7 after 60 mins
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL225284 5ht7r_rat Rat Yes 9.7 Ki = 0.2 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
452 9 1 4 5.0 CSC1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL611472 5ht7r_rat Rat No 9.6 Ki = 0.3 Funct
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
301 2 0 1 5.6 CN(C)C1CCC2=C(C=CC=C2C1)C3=CC=CC4=CC=CC=C43
CHEMBL592752 5ht7r_human Human Yes 9.6 Ki = 0.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
304 3 0 1 4.2 CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
CHEMBL592752 5ht7r_human Human Yes 9.6 Ki = 0.3 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
304 3 0 1 4.2 CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4
CHEMBL182923 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
317 7 2 3 5.0 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCC3=CC=CC=C3
CHEMBL183277 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
352 8 2 6 4.5 CC(C1=CC=CC=C1)NC2=NC(=NC=C2)NCCOC3=CC=C(C=C3)F
CHEMBL2159465 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
421 8 1 6 4.4 CC(C)C1=CC=CC=C1OCCN2CCC(CC2)NS(=O)(=O)C3=CC=C(C=C3)F
CHEMBL596959 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
358 6 0 1 7.3 CCCN(CCC)C1CCC2=C(C=CC=C2C1)C3=CC=CC4=CC=CC=C43
CHEMBL182923 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
317 7 2 3 5.0 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCC3=CC=CC=C3
CHEMBL183277 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
352 8 2 6 4.5 CC(C1=CC=CC=C1)NC2=NC(=NC=C2)NCCOC3=CC=C(C=C3)F
CHEMBL2159465 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
421 8 1 6 4.4 CC(C)C1=CC=CC=C1OCCN2CCC(CC2)NS(=O)(=O)C3=CC=C(C=C3)F
CHEMBL596959 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
358 6 0 1 7.3 CCCN(CCC)C1CCC2=C(C=CC=C2C1)C3=CC=CC4=CC=CC=C43
CHEMBL414628 5ht7r_human Human No 9.5 Ki = 0.3 Funct
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand (n=3)
499 4 1 6 2.8 COC1=C(C=C(C=C1)S(=O)(=O)N2CCC3=C2C=C(C=C3)I)N4CCNCC4
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL260994 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
384 6 1 3 4.1 C1CN(CCN1CCCCC2C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)Cl
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL260994 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
384 6 1 3 4.1 C1CN(CCN1CCCCC2C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)Cl
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL261719 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL605081 5ht7r_human Human Yes 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
318 3 0 1 4.5 CC1=CC=C(C=C1)CCN2C3=C(CN(CC3)C)C4=C2C=CC(=C4)C
CHEMBL605081 5ht7r_human Human Yes 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
318 3 0 1 4.5 CC1=CC=C(C=C1)CCN2C3=C(CN(CC3)C)C4=C2C=CC(=C4)C
CHEMBL181356 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
333 8 2 4 4.7 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCOC3=CC=CC=C3
CHEMBL183423 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
351 8 2 5 4.8 CC(C1=CC=CC=C1)NC2=NC=CC(=C2)NCCOC3=CC=C(C=C3)F
CHEMBL181605 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
335 7 2 4 5.1 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCC3=CC=C(C=C3)F
CHEMBL184607 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
333 8 2 4 4.7 CC(C1=CC=CC=C1)NC2=NC=CC(=C2)NCCOC3=CC=CC=C3
CHEMBL85 5ht7r_human Human Yes 9.4 Ki = 0.4 Funct
Displacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting methodDisplacement of [3H]-5-CT from human 5-HT7R expressed in HEK293 cell membranes after 1 hr at 37 degC by microbeta counting method
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL408976 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL3290004 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
454 6 1 7 4.3 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCNS(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL181356 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
333 8 2 4 4.7 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCOC3=CC=CC=C3
CHEMBL183423 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
351 8 2 5 4.8 CC(C1=CC=CC=C1)NC2=NC=CC(=C2)NCCOC3=CC=C(C=C3)F
CHEMBL181605 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
335 7 2 4 5.1 CC(C1=CC=CC=C1)NC2=CC(=NC=C2)NCCC3=CC=C(C=C3)F
CHEMBL184607 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
333 8 2 4 4.7 CC(C1=CC=CC=C1)NC2=NC=CC(=C2)NCCOC3=CC=CC=C3
CHEMBL408976 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL3290004 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
454 6 1 7 4.3 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCNS(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL267062 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
388 4 1 2 4.2 C1CC2=CC=CC=C2C(=O)N(C1)CCN3CCC(CC3)C4=CNC5=CC=CC=C54
CHEMBL408976 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL408976 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
412 7 1 3 4.9 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL260872 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
396 7 1 4 4.3 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)F
CHEMBL260872 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
396 7 1 4 4.3 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)F
CHEMBL260872 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
396 7 1 4 4.3 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)F
CHEMBL260872 5ht7r_human Human No 9.4 Ki = 0.4 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
396 7 1 4 4.3 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)F
CHEMBL261209 5ht7r_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
384 6 1 3 4.1 C1CN(CCN1CCCCC2C3=CC=CC=C3NC2=O)C4=CC(=CC=C4)Cl
CHEMBL261209 5ht7r_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
384 6 1 3 4.1 C1CN(CCN1CCCCC2C3=CC=CC=C3NC2=O)C4=CC(=CC=C4)Cl
CHEMBL261209 5ht7r_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
384 6 1 3 4.1 C1CN(CCN1CCCCC2C3=CC=CC=C3NC2=O)C4=CC(=CC=C4)Cl
CHEMBL261209 5ht7r_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
384 6 1 3 4.1 C1CN(CCN1CCCCC2C3=CC=CC=C3NC2=O)C4=CC(=CC=C4)Cl
CHEMBL3290002 5ht7r_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
468 7 1 7 4.7 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL3290002 5ht7r_human Human No 9.3 Ki = 0.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
468 7 1 7 4.7 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL413707 5ht7r_human Human No 9.3 Ki = 0.5 Funct
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
472 7 1 6 4.5 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)OC5=CC=C(C=C5)F
CHEMBL9951 5ht7r_human Human No 9.3 Ki = 0.6 Funct
Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.Binding affinity at human cloned 5-hydroxytryptamine 7 receptor.
406 4 0 3 4.1 C1CC2=CC=CC=C2C(=O)N(C1)CCN3CCC(CC3)N4C=CC5=C4C=CC(=C5)F
CHEMBL522691 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_rat Rat Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_rat Rat Yes 9.2 Ki = 0.6 Funct
Binding affinity to rat 5HT7 receptorBinding affinity to rat 5HT7 receptor
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_rat Rat Yes 9.2 Ki = 0.6 Funct
Binding affinity to rat cloned 5HT7 receptorBinding affinity to rat cloned 5HT7 receptor
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-countingDisplacement of [3H]-5-CT from human 5-HT7 receptor expressed in HEK293 cells after 1 hr by beta-counting
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells after 1 hr
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL522691 5ht7r_rat Rat Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
467 10 1 4 5.0 C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL185384 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
318 7 2 4 4.7 CC(C1=CC=CC=C1)NC2=NC(=NC=C2)NCCC3=CC=CC=C3
CHEMBL2164327 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Binding affinity to 5-HT7 receptor (unknown origin)Binding affinity to 5-HT7 receptor (unknown origin)
283 2 0 2 3.4 CC1=C(C(=NN1C)C)C2=C3CCC(CC3=CC=C2)N(C)C
CHEMBL8618 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
393 7 0 5 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL161765 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]5CT from 5HT7B receptorDisplacement of [3H]5CT from 5HT7B receptor
258 5 0 3 3.4 CN(C)CCSC1=CC=CC(=N1)C2=CC=CC=C2
CHEMBL259087 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
446 7 1 3 5.5 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3289991 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
432 7 1 7 3.8 CC1=CC(=CC=C1)S(=O)(=O)NCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL406414 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
430 7 1 4 5.0 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)F)Cl
CHEMBL185384 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
318 7 2 4 4.7 CC(C1=CC=CC=C1)NC2=NC(=NC=C2)NCCC3=CC=CC=C3
CHEMBL2164327 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Binding affinity to human 5HT7 receptor expressed in HEK-293F cellsBinding affinity to human 5HT7 receptor expressed in HEK-293F cells
283 2 0 2 3.4 CC1=C(C(=NN1C)C)C2=C3CCC(CC3=CC=C2)N(C)C
CHEMBL161765 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
258 5 0 3 3.4 CN(C)CCSC1=CC=CC(=N1)C2=CC=CC=C2
CHEMBL8618 5ht7r_human Human Yes 9.2 Ki = 0.6 Funct
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
393 7 0 5 3.2 COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O
CHEMBL259087 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
446 7 1 3 5.5 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)Cl)Cl
CHEMBL3289991 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
432 7 1 7 3.8 CC1=CC(=CC=C1)S(=O)(=O)NCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL406414 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
430 7 1 4 5.0 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)F)Cl
CHEMBL395444 5ht7r_rat Rat No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
695 18 0 9 7.1 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC(=CC=C3)OCCOCCOC4=CC=CC(=C4)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL395444 5ht7r_rat Rat No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
695 18 0 9 7.1 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC(=CC=C3)OCCOCCOC4=CC=CC(=C4)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL259087 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
446 7 1 3 5.5 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)Cl)Cl
CHEMBL259087 5ht7r_human Human No 9.2 Ki = 0.6 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
446 7 1 3 5.5 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)Cl)Cl
CHEMBL259086 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
426 7 1 3 5.2 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)C)Cl
CHEMBL259086 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
426 7 1 3 5.2 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCN(CC3)C4=CC(=C(C=C4)C)Cl
CHEMBL259549 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
430 7 1 4 5.0 CCC1(C2=C(C=C(C=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL259549 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
430 7 1 4 5.0 CCC1(C2=C(C=C(C=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL430706 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
477 6 2 4 4.5 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)C5=CNC6=CC=CC=C65
CHEMBL430706 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
477 6 2 4 4.5 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)C5=CNC6=CC=CC=C65
CHEMBL430706 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
477 6 2 4 4.5 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)C5=CNC6=CC=CC=C65
CHEMBL158402 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
264 5 0 3 3.9 CN(C)CCSC1=CC=CC(=N1)C2CCCCC2
CHEMBL3321794 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
346 6 0 2 3.8 C1CN(CC2=CC=CC=C21)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL3290017 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
536 8 1 8 6.1 CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NCCCCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL3289970 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
483 8 1 7 4.6 C1CN(CCN1CCCCNS(=O)(=O)C2=CC(=C(C=C2)Cl)Cl)C3=NOC4=CC=CC=C43
CHEMBL158402 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
264 5 0 3 3.9 CN(C)CCSC1=CC=CC(=N1)C2CCCCC2
CHEMBL158402 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cellsDisplacement of [3H]5CT from human cloned 5HT7B receptor expressed in HEK293 cells
264 5 0 3 3.9 CN(C)CCSC1=CC=CC(=N1)C2CCCCC2
CHEMBL3321794 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometryDisplacement of [3H]LSD from human 5-HT7 expressed in HEK-293 cells after 120 mins by scintillation spectrometry
346 6 0 2 3.8 C1CN(CC2=CC=CC=C21)CCC=CCCN3C(=O)CC4=CC=CC=C43
CHEMBL3290017 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
536 8 1 8 6.1 CC1=C(SC2=C1C=C(C=C2)Cl)S(=O)(=O)NCCCCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL3289970 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
483 8 1 7 4.6 C1CN(CCN1CCCCNS(=O)(=O)C2=CC(=C(C=C2)Cl)Cl)C3=NOC4=CC=CC=C43
CHEMBL115262 5ht7r_human Human No 9.2 Ki = 0.7 Funct
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
494 6 2 5 3.2 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)N5C6=CC=CC=C6NC5=O
CHEMBL409662 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
430 7 1 4 5.0 CCC1(C2=C(C=C(C=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL409662 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
430 7 1 4 5.0 CCC1(C2=C(C=C(C=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL409662 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
430 7 1 4 5.0 CCC1(C2=C(C=C(C=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL409662 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
430 7 1 4 5.0 CCC1(C2=C(C=C(C=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL116292 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
500 7 1 5 4.6 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)C(=O)C5=CC=C(C=C5)Cl
CHEMBL3290003 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
482 8 1 7 5.0 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL3289978 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
465 8 1 7 4.6 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=NOC5=CC=CC=C54
CHEMBL3290005 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
468 7 1 7 4.7 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL492871 5ht7r_rat Rat Yes 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
442 10 1 3 5.3 C1CN(CCN1CCCCCC(=O)NCC2=CC=CC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL3290003 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
482 8 1 7 5.0 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL3289978 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
465 8 1 7 4.6 C1CN(CCN1CCCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=NOC5=CC=CC=C54
CHEMBL3290005 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
468 7 1 7 4.7 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL492871 5ht7r_rat Rat Yes 9.1 Ki = 0.8 Funct
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
442 10 1 3 5.3 C1CN(CCN1CCCCCC(=O)NCC2=CC=CC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL609675 5ht7r_rat Rat No 9.1 Ki = 0.8 Funct
Binding affinity at rat 5-hydroxytryptamine 7 receptor.Binding affinity at rat 5-hydroxytryptamine 7 receptor.
282 2 1 1 4.3 CC1=C(NC(=C1C2=C3CCC(CC3=CC=C2)N(C)C)C)C
CHEMBL114345 5ht7r_human Human No 9.1 Ki = 0.8 Funct
Binding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligandBinding affinity for human cloned 5-hydroxytryptamine 7 receptor in HEK 293 using [3H]5-CT as a radioligand
484 7 1 6 4.1 C1CC(N(C1)S(=O)(=O)C2=CC3=C(C=C2)C=CN3)CCN4CCC(CC4)C(=O)C5=CC=C(C=C5)F
CHEMBL3289995 5ht7r_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
470 7 1 8 4.2 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC(=C(C=C4)F)Cl
CHEMBL3289999 5ht7r_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
424 7 1 8 3.5 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC=CS4
CHEMBL3290009 5ht7r_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
474 7 1 8 4.5 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CSC5=CC=CC=C54
CHEMBL243955 5ht7r_rat Rat No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
449 9 1 4 4.6 CN(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL239656 5ht7r_rat Rat No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
679 17 0 8 8.0 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC(=CC=C3)OCCCCOC4=CC=CC(=C4)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL159022 5ht7r_rat Rat No 9.1 Ki = 0.9 Funct
Binding affinity to the rat 5-hydroxytryptamine 7 receptorBinding affinity to the rat 5-hydroxytryptamine 7 receptor
408 9 0 6 4.3 COC1=CC=CC=C1C(=O)CCCCCN2CCN(CC2)C3=NOC4=CC=CC=C43
CHEMBL3289995 5ht7r_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
470 7 1 8 4.2 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC(=C(C=C4)F)Cl
CHEMBL3289999 5ht7r_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
424 7 1 8 3.5 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC=CS4
CHEMBL3290009 5ht7r_human Human No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
474 7 1 8 4.5 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CSC5=CC=CC=C54
CHEMBL243955 5ht7r_rat Rat No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
449 9 1 4 4.6 CN(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL239656 5ht7r_rat Rat No 9.1 Ki = 0.9 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
679 17 0 8 8.0 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC(=CC=C3)OCCCCOC4=CC=CC(=C4)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL494709 5ht7r_rat Rat No 9.0 Ki = 1.0 Funct
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
443 10 1 4 4.2 C1CN(CCN1CCCCCC(=O)NCC2=CC=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL494709 5ht7r_rat Rat No 9.0 Ki = 1.0 Funct
Displacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat cloned 5HT7 receptor expressed in HEK293 cells
443 10 1 4 4.2 C1CN(CCN1CCCCCC(=O)NCC2=CC=NC=C2)C3=CC=CC=C3C4=CC=CC=C4
CHEMBL3331258 5ht7r_human Human No 9.0 Ki = 1.0 Funct
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
382 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCCCN3C4=CC=CC=C4SC3=O
CHEMBL3331258 5ht7r_human Human No 9.0 Ki = 1.0 Funct
Displacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometryDisplacement of [3H]5-HT from human 5HT7 receptor transfected in CFO-K1 cells after 30 mins by liquid scintillation spectrometry
382 6 0 4 4.6 CC1=CC=CC=C1N2CCN(CC2)CCCCN3C4=CC=CC=C4SC3=O
CHEMBL182071 5ht7r_human Human No 9.0 Ki = 1 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
352 8 2 6 4.5 CC(C1=CC=CC=C1)NC2=NC=CC(=N2)NCCOC3=CC=C(C=C3)F
CHEMBL428892 5ht7r_rat Rat No 9.0 Ki = 1 Funct
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
357 2 0 4 4.2 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL3759205 5ht7r_human Human No 9.0 Ki = 1 Funct
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
447 8 1 6 5.0 CC(C)C1=CC(=CC=C1)OCCN2C3CCC2CC(C3)NS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL85 5ht7r_human Human Yes 9.0 Ki = 1 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL258075 5ht7r_human Human Yes 9.0 Ki = 1 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
219 2 2 2 1.3 CC1C2=C(C(=CC=C2)OC(C)C)NC(=N1)N
CHEMBL182071 5ht7r_human Human No 9.0 Ki = 1 Funct
Binding affinity against 5-Hydroxy tryptamine 7 receptorBinding affinity against 5-Hydroxy tryptamine 7 receptor
352 8 2 6 4.5 CC(C1=CC=CC=C1)NC2=NC=CC(=N2)NCCOC3=CC=C(C=C3)F
CHEMBL428892 5ht7r_rat Rat No 9.0 Ki = 1 Funct
Binding affinity towards 5-hydroxytryptamine 7 receptorBinding affinity towards 5-hydroxytryptamine 7 receptor
357 2 0 4 4.2 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL28056 5ht7r_human Human No 9.0 Ki = 1 Funct
Binding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSDBinding affinity towards human 5-hydroxytryptamine 7 receptor on HEK293 cells using radioligand [3H]LSD
350 1 0 2 5.2 CC1=CC=CC(=C1C2=C3C(=CC=C2)CC4C5=C3C=CC=C5CCN4C)C#N
CHEMBL428892 5ht7r_rat Rat No 9.0 Ki = 1 Funct
Binding affinity towards rat 5-HT7 receptor expressed in HEK cellsBinding affinity towards rat 5-HT7 receptor expressed in HEK cells
357 2 0 4 4.2 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL3759205 5ht7r_human Human No 9.0 Ki = 1 Funct
Displacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]-5-CT from human 5-HT7B receptor expressed in HEK293 cells after 1 hr
447 8 1 6 5.0 CC(C)C1=CC(=CC=C1)OCCN2C3CCC2CC(C3)NS(=O)(=O)C4=CC=C(C=C4)F
CHEMBL85 5ht7r_human Human Yes 9.0 Ki = 1 Funct
Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human 5HT7 receptor expressed in CHO cells
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL258075 5ht7r_human Human Yes 9.0 Ki = 1 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in HEK293-EBNA cells
219 2 2 2 1.3 CC1C2=C(C(=CC=C2)OC(C)C)NC(=N1)N
CHEMBL428892 5ht7r_human Human No 9.0 Ki = 1 Funct
Non-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptorNon-selective inhibitory activity was determined against 5-hydroxytryptamine 7 receptor
357 2 0 4 4.2 CN1CCN(CC1)C2CC3=CC=CC=C3SC4=C2C=C(C=C4)SC
CHEMBL410226 5ht7r_human Human No 9.0 Ki = 1.0 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
409 7 1 2 5.1 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCC(=CC3)C4=CC=C(C=C4)Cl
CHEMBL410226 5ht7r_human Human No 9.0 Ki = 1.0 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
409 7 1 2 5.1 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCC(=CC3)C4=CC=C(C=C4)Cl
CHEMBL154274 5ht7r_human Human No 9.0 Ki = 1.0 Funct
Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)Compound was evaluated for binding affinity against human cloned 5-hydroxytryptamine 7 receptor in HEK 293 cells using [3H]5-CT as the radioligand(n=6)
505 5 2 6 3.3 COC1=C(C=C(C=C1)S(=O)(=O)NC2=C(C=CC(=C2)Br)Br)N3CCNCC3
CHEMBL281923 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL281923 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]5CT from 5HT7 receptorDisplacement of [3H]5CT from 5HT7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL281924 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL269083 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
446 7 1 3 5.5 CCC1(C2=C(C=CC(=C2)Cl)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL3289990 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
417 6 1 7 3.4 CC1=CC(=CC=C1)S(=O)(=O)NCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL3289968 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
429 8 1 7 3.7 CC1=CC(=CC=C1)S(=O)(=O)NCCCCN2CCN(CC2)C3=NOC4=CC=CC=C43
CHEMBL243744 5ht7r_rat Rat No 9.0 Ki = 1.1 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
448 9 1 3 5.6 CC(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL281924 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Binding affinity at 5HT7 receptorBinding affinity at 5HT7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL281923 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL281924 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Binding affinity towards human 5-hydroxytryptamine 7 receptorBinding affinity towards human 5-hydroxytryptamine 7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL281923 5ht7r_rat Rat No 9.0 Ki = 1.1 Funct
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL281924 5ht7r_rat Rat No 9.0 Ki = 1.1 Funct
Displacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptorDisplacement of [3H]5-HT from over-expressed rat 5-hydroxytryptamine 7 receptor
291 1 0 2 3.1 CC1(C2=C3C4=C(CCN(C4CC5=C3C1=CC=C5)C)C=C2)OC
CHEMBL269083 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
446 7 1 3 5.5 CCC1(C2=C(C=CC(=C2)Cl)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL3289990 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
417 6 1 7 3.4 CC1=CC(=CC=C1)S(=O)(=O)NCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL3289968 5ht7r_human Human No 9.0 Ki = 1.1 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
429 8 1 7 3.7 CC1=CC(=CC=C1)S(=O)(=O)NCCCCN2CCN(CC2)C3=NOC4=CC=CC=C43
CHEMBL243744 5ht7r_rat Rat No 9.0 Ki = 1.1 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cellsDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells
448 9 1 3 5.6 CC(C)C1=CC=CC=C1N2CCN(CC2)CCCCCC(=O)NC3CCCC4=CC=CC=C34
CHEMBL410225 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
393 7 1 3 4.6 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCC(=CC3)C4=CC=C(C=C4)F
CHEMBL410225 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
393 7 1 3 4.6 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCC(=CC3)C4=CC=C(C=C4)F
CHEMBL410225 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
393 7 1 3 4.6 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCC(=CC3)C4=CC=C(C=C4)F
CHEMBL3289993 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
486 7 1 7 4.7 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL410225 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometryDisplacement of [3H]CT from human 5-HT7 receptor expressed in CHO cells by scintillation spectrometry
393 7 1 3 4.6 CCC1(C2=CC=CC=C2NC1=O)CCCCN3CCC(=CC3)C4=CC=C(C=C4)F
CHEMBL3289993 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
486 7 1 7 4.7 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC(=C(C=C4)Cl)Cl
CHEMBL262068 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
426 8 1 3 5.4 CCC1(C2=CC=CC=C2NC1=O)CCCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL262068 5ht7r_human Human No 8.9 Ki = 1.2 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
426 8 1 3 5.4 CCC1(C2=CC=CC=C2NC1=O)CCCCCN3CCN(CC3)C4=CC=C(C=C4)Cl
CHEMBL3290020 5ht7r_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
475 7 1 9 3.9 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC=CC5=C4N=CS5
CHEMBL3290014 5ht7r_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
522 8 1 8 5.8 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC5=C(S4)C=C(C=C5)Cl
CHEMBL3290001 5ht7r_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
454 6 1 7 4.3 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL158973 5ht7r_human Human No 8.9 Ki = 1.3 Funct
Binding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cellsBinding affinity towards human 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-HT radioligand from the cloned receptor expressed in CHO cells
161 4 0 2 1.9 CC(C)(C)SCCN(C)C
CHEMBL3290020 5ht7r_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
475 7 1 9 3.9 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCNS(=O)(=O)C4=CC=CC5=C4N=CS5
CHEMBL3290014 5ht7r_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
522 8 1 8 5.8 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC5=C(S4)C=C(C=C5)Cl
CHEMBL3290001 5ht7r_human Human No 8.9 Ki = 1.3 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
454 6 1 7 4.3 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCNS(=O)(=O)C4=CC=CC5=CC=CC=C54
CHEMBL3290006 5ht7r_human Human No 8.9 Ki = 1.4 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
482 8 1 7 5.0 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL85 5ht7r_rat Rat Yes 8.9 Ki = 1.4 Funct
Binding affinity towards rat 5-hydroxytryptamine 7 receptorBinding affinity towards rat 5-hydroxytryptamine 7 receptor
411 4 0 6 2.7 CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
CHEMBL2164330 5ht7r_human Human Yes 8.9 Ki = 1.4 Funct
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
252 2 1 2 3.4 CC1=CC=CC=C1C2=CC(=CC=C2)N3CCNCC3
CHEMBL494675 5ht7r_human Human Yes 8.9 Ki = 1.4 Funct
Displacement of [3H]-5-CT from human cloned 5HT7 receptorDisplacement of [3H]-5-CT from human cloned 5HT7 receptor
238 2 1 2 3.5 C1CN(CCN1)C2=CC=CC=C2C3=CC=CC=C3
CHEMBL3290006 5ht7r_human Human No 8.9 Ki = 1.4 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
482 8 1 7 5.0 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC5=CC=CC=C5C=C4
CHEMBL258496 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
426 8 1 3 5.4 CCC1(C2=CC=CC=C2NC1=O)CCCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL258496 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
426 8 1 3 5.4 CCC1(C2=CC=CC=C2NC1=O)CCCCCN3CCN(CC3)C4=CC(=CC=C4)Cl
CHEMBL3289992 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
446 8 1 7 4.2 CC1=CC(=CC=C1)S(=O)(=O)NCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL3289953 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
467 7 1 7 4.9 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=NSC5=CC=CC=C54
CHEMBL3289952 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
453 6 1 7 4.5 C1CN(CCN1CCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=NSC5=CC=CC=C54
CHEMBL259216 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
414 7 1 5 4.4 CCC1(C2=C(C=CC(=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)F
CHEMBL3289992 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
446 8 1 7 4.2 CC1=CC(=CC=C1)S(=O)(=O)NCCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F
CHEMBL3289953 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
467 7 1 7 4.9 C1CN(CCN1CCCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=NSC5=CC=CC=C54
CHEMBL3289952 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
453 6 1 7 4.5 C1CN(CCN1CCNS(=O)(=O)C2=CC3=CC=CC=C3C=C2)C4=NSC5=CC=CC=C54
CHEMBL259216 5ht7r_human Human No 8.8 Ki = 1.5 Funct
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cellsDisplacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells
414 7 1 5 4.4 CCC1(C2=C(C=CC(=C2)F)NC1=O)CCCCN3CCN(CC3)C4=CC=C(C=C4)F
CHEMBL3289944 5ht7r_human Human No 8.8 Ki = 1.6 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
445 8 1 7 4.3 CC1=CC(=CC=C1)S(=O)(=O)NCCCCN2CCN(CC2)C3=NSC4=CC=CC=C43
CHEMBL3290012 5ht7r_human Human No 8.8 Ki = 1.6 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysisDisplacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid scintillation counting analysis
488 8 1 8 5.1 C1CN(CCC1C2=NOC3=C2C=CC(=C3)F)CCCCNS(=O)(=O)C4=CC5=CC=CC=C5S4
CHEMBL396844 5ht7r_rat Rat No 8.8 Ki = 1.6 Funct
Displacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uMDisplacement of [3H]LSD from rat recombinant 5HT7 receptor expressed in HEK293 cells at 10 uM
707 19 0 8 8.7 COC1=CC=CC=C1N2CCN(CC2)CCC3=CC(=CC=C3)OCCCCCCOC4=CC=CC(=C4)CCN5CCN(CC5)C6=CC=CC=C6OC
CHEMBL3289944 5ht7r_human Human No 8.8 Ki = 1.6 Funct
Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO-K1 cell membrane after 120 mins by liquid s